AU2009288088B2 - Agents and methods for treatment of pain - Google Patents

Agents and methods for treatment of pain Download PDF

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Publication number
AU2009288088B2
AU2009288088B2 AU2009288088A AU2009288088A AU2009288088B2 AU 2009288088 B2 AU2009288088 B2 AU 2009288088B2 AU 2009288088 A AU2009288088 A AU 2009288088A AU 2009288088 A AU2009288088 A AU 2009288088A AU 2009288088 B2 AU2009288088 B2 AU 2009288088B2
Authority
AU
Australia
Prior art keywords
pain
peptide
tat
nr2b9c
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009288088A
Other languages
English (en)
Other versions
AU2009288088A1 (en
Inventor
Michael P. Belmares
J. David Garman
Peter S. Lu
Michael W. Salter
Michael Tymianski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NoNO Inc
Original Assignee
NoNO Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NoNO Inc filed Critical NoNO Inc
Publication of AU2009288088A1 publication Critical patent/AU2009288088A1/en
Assigned to NONO INC. reassignment NONO INC. Request for Assignment Assignors: ARBOR VITA CORPORATION, NONO INC.
Application granted granted Critical
Publication of AU2009288088B2 publication Critical patent/AU2009288088B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2009288088A 2008-09-03 2009-09-02 Agents and methods for treatment of pain Ceased AU2009288088B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9402608P 2008-09-03 2008-09-03
US61/094,026 2008-09-03
PCT/US2009/055786 WO2010028089A2 (en) 2008-09-03 2009-09-02 Agents and methods for treatment of pain

Publications (2)

Publication Number Publication Date
AU2009288088A1 AU2009288088A1 (en) 2010-03-11
AU2009288088B2 true AU2009288088B2 (en) 2014-12-04

Family

ID=41797838

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009288088A Ceased AU2009288088B2 (en) 2008-09-03 2009-09-02 Agents and methods for treatment of pain

Country Status (7)

Country Link
US (3) US8324168B2 (enExample)
EP (1) EP2334315B1 (enExample)
JP (1) JP5801197B2 (enExample)
CN (1) CN102202677A (enExample)
AU (1) AU2009288088B2 (enExample)
CA (1) CA2739416C (enExample)
WO (1) WO2010028089A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2446306T3 (es) * 2008-05-16 2014-03-07 Nono Inc. Uso de un inhibidor de psd-95 tratamiento para la epilepsia
AU2009288088B2 (en) 2008-09-03 2014-12-04 Nono Inc. Agents and methods for treatment of pain
ES2584068T3 (es) * 2010-10-01 2016-09-23 Nsgene A/S Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma
EP2852397B1 (en) * 2012-05-18 2022-02-16 Janssen Biotech, Inc. Huwentoxin-iv variants and methods of use
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10251935B2 (en) 2012-11-28 2019-04-09 Nono Inc. Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose
HUE043820T2 (hu) * 2012-11-28 2019-09-30 Nono Inc Liofilizált TAT-NR2B9c készítmény
CN103012597B (zh) * 2012-12-31 2014-06-11 黑龙江大学 用于治疗骨质疏松症和止痛的OGP-CTx融合蛋白及编码该融合蛋白的核酸
US9624280B2 (en) 2013-10-03 2017-04-18 Janssen Biotech, Inc. Protoxin-II variants and methods of use
WO2015164383A1 (en) * 2014-04-22 2015-10-29 Q-State Biosciences, Inc. Models for parkinson's disease studies
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
ES2888799T3 (es) 2015-04-02 2022-01-07 Janssen Biotech Inc Variantes de Protoxina-II y métodos de uso
CN107312071B (zh) * 2016-04-27 2018-11-06 拜西欧斯(北京)生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
JP2019522675A (ja) * 2016-04-27 2019-08-15 ▲拝▼西欧斯(北京)生物技▲術▼有限公司 興奮製神経毒性に関連した損傷の治療方法
CN107913395B (zh) * 2016-10-10 2019-12-13 拜西欧斯(北京)生物技术有限公司 神经兴奋性损伤相关多肽在预防、缓解或治疗疼痛的用途
KR102403089B1 (ko) * 2017-07-05 2022-06-02 바이오셀즈(베이징) 바이오테크 코., 엘티디. 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도
JP7073486B2 (ja) * 2017-09-30 2022-05-23 ▲拝▼西欧斯(北京)生物技▲術▼有限公司 興奮性神経毒性に関連した損傷の治療用ペプチド組成物
CN109106942B (zh) * 2018-09-18 2019-11-22 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽在制备药物中的应用
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
CN109265558B (zh) * 2018-09-18 2019-12-24 深圳瑞健生物科技有限公司 改进型齐考诺肽在制备药物中的应用
CN109265557B (zh) * 2018-09-18 2019-12-24 深圳瑞健生物科技有限公司 一种齐考诺肽和tat肽的融合多肽在制备药物中的应用
CN118324862A (zh) * 2018-12-26 2024-07-12 思亲美有限公司 乙酰胆碱受体抑制肽及其用途
CN111097037A (zh) * 2020-01-16 2020-05-05 刘成龙 一种psd95-pdz1/2结构域抑制剂及其应用
WO2024199436A1 (zh) * 2023-03-31 2024-10-03 青岛普美圣医药科技有限公司 具有延长的半衰期和提高的稳定性的多肽活性分子

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050164933A1 (en) * 2003-12-23 2005-07-28 Michael Tymianski Method of reducing injury to mammalian cells
US20070059320A1 (en) * 2004-03-30 2007-03-15 Hospital For Sick Children Method for ameliorating pain by modification of NMDA receptors through inhibition of Src
EP1884521A1 (en) * 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
WO2008124698A2 (en) * 2007-04-06 2008-10-16 Kai Pharmaceuticals, Inc. Methods of use of gamma inhibitor compounds for the attenuation of pain

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7760905B2 (en) 1999-06-29 2010-07-20 Digimarc Corporation Wireless mobile phone with content processing
US7595297B2 (en) 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US7510824B2 (en) 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
US6759520B1 (en) 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20080227684A1 (en) 2005-12-30 2008-09-18 Belmares Michael P Small Molecule Inhibitors of PDZ Interactions
US8633160B2 (en) 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
GB0610868D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
US20080019969A1 (en) * 2006-07-07 2008-01-24 Gorman James R Methods for Preventing, Postponing or Improving the Outcome of Invasive Spinal Procedures
US20080124698A1 (en) 2006-11-28 2008-05-29 Ebensberger Jason M Virtual coatings application system with structured training and remote instructor capabilities
US20080233152A1 (en) * 2006-12-29 2008-09-25 Revance Therapeutics, Inc. Compositions and Methods of Topical Application and Transdermal Delivery of Botulinum Toxins Stabilized with Polypeptide Fragments Derived from HIV-TAT
JP5631595B2 (ja) 2007-03-02 2014-11-26 ノノ インコーポレイテッド N型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法
WO2008131099A1 (en) * 2007-04-19 2008-10-30 The Johns Hopkins University Biological agents active in central nervous system
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
US8080518B2 (en) 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
ES2446306T3 (es) 2008-05-16 2014-03-07 Nono Inc. Uso de un inhibidor de psd-95 tratamiento para la epilepsia
AU2009288088B2 (en) 2008-09-03 2014-12-04 Nono Inc. Agents and methods for treatment of pain
AU2010327936B2 (en) 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050164933A1 (en) * 2003-12-23 2005-07-28 Michael Tymianski Method of reducing injury to mammalian cells
US20070059320A1 (en) * 2004-03-30 2007-03-15 Hospital For Sick Children Method for ameliorating pain by modification of NMDA receptors through inhibition of Src
EP1884521A1 (en) * 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
WO2008124698A2 (en) * 2007-04-06 2008-10-16 Kai Pharmaceuticals, Inc. Methods of use of gamma inhibitor compounds for the attenuation of pain

Also Published As

Publication number Publication date
EP2334315A4 (en) 2012-08-15
JP2012501973A (ja) 2012-01-26
EP2334315A2 (en) 2011-06-22
CA2739416C (en) 2017-10-31
US20100062985A1 (en) 2010-03-11
US8324168B2 (en) 2012-12-04
JP5801197B2 (ja) 2015-10-28
US9365620B2 (en) 2016-06-14
WO2010028089A2 (en) 2010-03-11
CA2739416A1 (en) 2010-03-11
EP2334315B1 (en) 2023-01-18
US20150018283A1 (en) 2015-01-15
AU2009288088A1 (en) 2010-03-11
WO2010028089A3 (en) 2010-04-29
CN102202677A (zh) 2011-09-28
US8748387B2 (en) 2014-06-10
US20130137641A1 (en) 2013-05-30

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: NONO INC.

Free format text: FORMER APPLICANT(S): ARBOR VITA CORPORATION; NONO INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired