CA2739416C - Agents and methods for treatment of pain - Google Patents

Agents and methods for treatment of pain Download PDF

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Publication number
CA2739416C
CA2739416C CA2739416A CA2739416A CA2739416C CA 2739416 C CA2739416 C CA 2739416C CA 2739416 A CA2739416 A CA 2739416A CA 2739416 A CA2739416 A CA 2739416A CA 2739416 C CA2739416 C CA 2739416C
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CA
Canada
Prior art keywords
pain
tat
peptide
agent
nr2b9c
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2739416A
Other languages
English (en)
French (fr)
Other versions
CA2739416A1 (en
Inventor
Michael P. Belmares
J. David Garman
Peter S. Lu
Michael W. Salter
Michael Tymianski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NoNO Inc
Original Assignee
NoNO Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NoNO Inc filed Critical NoNO Inc
Publication of CA2739416A1 publication Critical patent/CA2739416A1/en
Application granted granted Critical
Publication of CA2739416C publication Critical patent/CA2739416C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2739416A 2008-09-03 2009-09-02 Agents and methods for treatment of pain Active CA2739416C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9402608P 2008-09-03 2008-09-03
US61/094,026 2008-09-03
PCT/US2009/055786 WO2010028089A2 (en) 2008-09-03 2009-09-02 Agents and methods for treatment of pain

Publications (2)

Publication Number Publication Date
CA2739416A1 CA2739416A1 (en) 2010-03-11
CA2739416C true CA2739416C (en) 2017-10-31

Family

ID=41797838

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2739416A Active CA2739416C (en) 2008-09-03 2009-09-02 Agents and methods for treatment of pain

Country Status (7)

Country Link
US (3) US8324168B2 (enExample)
EP (1) EP2334315B1 (enExample)
JP (1) JP5801197B2 (enExample)
CN (1) CN102202677A (enExample)
AU (1) AU2009288088B2 (enExample)
CA (1) CA2739416C (enExample)
WO (1) WO2010028089A2 (enExample)

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AU2009246316B2 (en) * 2008-05-16 2014-06-19 Nono Inc. Treatment for epilepsy
CA2739416C (en) 2008-09-03 2017-10-31 Arbor Vita Corporation Agents and methods for treatment of pain
AU2011307488B2 (en) * 2010-10-01 2015-08-20 Hoba Therapeutics Aps Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
AU2013262630B2 (en) * 2012-05-18 2017-11-16 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
AU2013352437B2 (en) * 2012-11-28 2018-04-12 Nono Inc. Lyophilized formulation of TAT-NR2B9c
US10251935B2 (en) 2012-11-28 2019-04-09 Nono Inc. Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose
CN103012597B (zh) * 2012-12-31 2014-06-11 黑龙江大学 用于治疗骨质疏松症和止痛的OGP-CTx融合蛋白及编码该融合蛋白的核酸
KR20160064192A (ko) 2013-10-03 2016-06-07 얀센 바이오테크 인코포레이티드 프로톡신-ii 변이체 및 사용 방법
JP2017518738A (ja) * 2014-04-22 2017-07-13 キュー−ステート バイオサイエンシーズ, インコーポレイテッドQ−State Biosciences, Inc. 化合物の光遺伝学的分析
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
CN107921089A (zh) 2015-04-02 2018-04-17 詹森生物科技公司 原毒素‑ii变体及使用方法
EP3450446A4 (en) * 2016-04-27 2019-03-06 Biocells (Beijing) Biotech Co., Ltd. METHOD OF TREATING ADVERSE NEUROTOXICITY-RELATED INJURIES
CN107312071B (zh) * 2016-04-27 2018-11-06 拜西欧斯(北京)生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
CN107913395B (zh) * 2016-10-10 2019-12-13 拜西欧斯(北京)生物技术有限公司 神经兴奋性损伤相关多肽在预防、缓解或治疗疼痛的用途
US11767344B2 (en) 2017-07-05 2023-09-26 Biocells (Beijing) Biotech Co., Ltd. Pharmaceutically acceptable salts of polypeptides and methods of inhibiting the interaction between psd-95 and n-methyl-d-aspartic acid receptor (nmdar)
BR112020006321A2 (pt) 2017-09-30 2020-11-17 Biocells (Beijing) Biotech Co., Ltd. composição de peptídeos para tratamento de lesões relacionadas a neurotoxicidade excitatória
CN109265557B (zh) * 2018-09-18 2019-12-24 深圳瑞健生物科技有限公司 一种齐考诺肽和tat肽的融合多肽在制备药物中的应用
CN109106942B (zh) * 2018-09-18 2019-11-22 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽在制备药物中的应用
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
CN109265558B (zh) * 2018-09-18 2019-12-24 深圳瑞健生物科技有限公司 改进型齐考诺肽在制备药物中的应用
CN118324862A (zh) * 2018-12-26 2024-07-12 思亲美有限公司 乙酰胆碱受体抑制肽及其用途
CN111097037A (zh) * 2020-01-16 2020-05-05 刘成龙 一种psd95-pdz1/2结构域抑制剂及其应用
CN120958011A (zh) * 2023-03-31 2025-11-14 青岛普美圣医药科技有限公司 具有延长的半衰期和提高的稳定性的多肽活性分子

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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US7760905B2 (en) 1999-06-29 2010-07-20 Digimarc Corporation Wireless mobile phone with content processing
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
US7595297B2 (en) 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US6759520B1 (en) 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20080119412A1 (en) * 2003-12-23 2008-05-22 Nono Inc. Polypeptides for Modulating Binding of Trp Channel Proteins and Trp- Associated Proteins
US8003609B2 (en) * 2004-03-30 2011-08-23 The Hospital For Sick Children Method for ameliorating pain by modification of NMDA receptors through inhibition of Src
US8633160B2 (en) * 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
US20080227684A1 (en) * 2005-12-30 2008-09-18 Belmares Michael P Small Molecule Inhibitors of PDZ Interactions
GB0610868D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
US20080019975A1 (en) * 2006-07-07 2008-01-24 Bioassets Development Corporation Novel Regimens for Treating Diseases and Disorders
EP1884521A1 (en) 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
US20080124698A1 (en) 2006-11-28 2008-05-29 Ebensberger Jason M Virtual coatings application system with structured training and remote instructor capabilities
CA2677202A1 (en) * 2006-12-29 2008-07-10 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat
JP5631595B2 (ja) * 2007-03-02 2014-11-26 ノノ インコーポレイテッド N型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法
EP2144615A4 (en) * 2007-04-06 2011-02-16 Kai Pharmaceuticals Inc METHOD OF USE OF GAMMA INHIBITOR COMPOUNDS FOR PAIN LIFTING
WO2008131099A1 (en) * 2007-04-19 2008-10-30 The Johns Hopkins University Biological agents active in central nervous system
US8008253B2 (en) * 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
US8080518B2 (en) * 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
AU2009246316B2 (en) * 2008-05-16 2014-06-19 Nono Inc. Treatment for epilepsy
CA2739416C (en) 2008-09-03 2017-10-31 Arbor Vita Corporation Agents and methods for treatment of pain
JP5848712B2 (ja) * 2009-12-11 2016-01-27 ノノ インコーポレイテッド 虚血性疾患および他の疾患を治療するための薬剤および方法

Also Published As

Publication number Publication date
US8748387B2 (en) 2014-06-10
CA2739416A1 (en) 2010-03-11
AU2009288088A1 (en) 2010-03-11
US8324168B2 (en) 2012-12-04
EP2334315A2 (en) 2011-06-22
WO2010028089A2 (en) 2010-03-11
US20100062985A1 (en) 2010-03-11
US9365620B2 (en) 2016-06-14
EP2334315A4 (en) 2012-08-15
US20150018283A1 (en) 2015-01-15
JP5801197B2 (ja) 2015-10-28
US20130137641A1 (en) 2013-05-30
WO2010028089A3 (en) 2010-04-29
AU2009288088B2 (en) 2014-12-04
JP2012501973A (ja) 2012-01-26
EP2334315B1 (en) 2023-01-18
CN102202677A (zh) 2011-09-28

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