CN102170909B - 抗-notch2抗体和使用方法 - Google Patents

抗-notch2抗体和使用方法 Download PDF

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Publication number
CN102170909B
CN102170909B CN200980139202.1A CN200980139202A CN102170909B CN 102170909 B CN102170909 B CN 102170909B CN 200980139202 A CN200980139202 A CN 200980139202A CN 102170909 B CN102170909 B CN 102170909B
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antibody
amino acid
seq
hvr
acid sequence
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CN102170909A (zh
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克里斯蒂安·W·西贝尔
吴岩
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980139202.1A 2008-10-01 2009-09-30 抗-notch2抗体和使用方法 Active CN102170909B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10191708P 2008-10-01 2008-10-01
US61/101,917 2008-10-01
PCT/US2009/059028 WO2010039832A1 (en) 2008-10-01 2009-09-30 Anti-notch2 antibodies and methods of use

Publications (2)

Publication Number Publication Date
CN102170909A CN102170909A (zh) 2011-08-31
CN102170909B true CN102170909B (zh) 2015-11-25

Family

ID=41349057

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980139202.1A Active CN102170909B (zh) 2008-10-01 2009-09-30 抗-notch2抗体和使用方法

Country Status (18)

Country Link
US (5) US8404239B2 (OSRAM)
EP (1) EP2334331B1 (OSRAM)
JP (2) JP5710487B2 (OSRAM)
KR (1) KR101712214B1 (OSRAM)
CN (1) CN102170909B (OSRAM)
AR (1) AR073717A1 (OSRAM)
AU (1) AU2009298569A1 (OSRAM)
BR (1) BRPI0913827A2 (OSRAM)
CA (1) CA2736429A1 (OSRAM)
CL (1) CL2011000711A1 (OSRAM)
ES (1) ES2541726T3 (OSRAM)
IL (1) IL211623A0 (OSRAM)
MX (1) MX2011002928A (OSRAM)
PE (1) PE20120080A1 (OSRAM)
RU (1) RU2580029C2 (OSRAM)
TW (1) TW201018484A (OSRAM)
WO (1) WO2010039832A1 (OSRAM)
ZA (1) ZA201101651B (OSRAM)

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CA2655362A1 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
NZ590127A (en) 2008-07-08 2012-11-30 Oncomed Pharm Inc Notch1 receptor binding agents and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
PE20120080A1 (es) * 2008-10-01 2012-02-17 Genentech Inc Anticuerpos anti-notch2 y metodos de uso
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
WO2012047583A2 (en) * 2010-09-27 2012-04-12 Janssen Biotech, Inc. Antibodies binding human collagen ii
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
WO2013173542A1 (en) * 2012-05-16 2013-11-21 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with notch2/3 antibodies
KR20200143502A (ko) 2012-08-13 2020-12-23 제넨테크, 인크. 항-jagged 항체 및 사용 방법
EP2970468B1 (en) 2013-03-13 2021-07-07 Novartis AG Notch2 binding molecules for treating respiratory diseases
JP6527132B2 (ja) 2013-03-15 2019-06-05 ジェネンテック， インコーポレイテッド 肝臓がんの診断及び治療のための組成物及び方法
JP6571115B2 (ja) 2014-02-12 2019-09-04 ジェネンテック， インコーポレイテッド 抗ｊａｇｇｅｄ１抗体及び使用方法
MX2017000363A (es) 2014-07-11 2017-04-27 Genentech Inc Inhibicion de la via de notch.
US10716829B2 (en) * 2015-09-26 2020-07-21 National Health Research Institutes Method and composition for treatment of hair loss
GB201521447D0 (en) * 2015-12-04 2016-01-20 Ucb Biopharma Sprl De novo antibody design
US10858443B2 (en) 2017-05-31 2020-12-08 Trustees Of Boston University Synthetic notch protein for modulating gene expression
CN116406377A (zh) * 2020-07-17 2023-07-07 基因泰克公司 抗notch2抗体及其使用方法
CN121057747A (zh) * 2023-04-18 2025-12-02 上海洛启生物医药技术有限公司 抗Notch2纳米抗体及其应用
CN120441700A (zh) * 2023-11-21 2025-08-08 兰州大学第二医院 一种抗人notch2单链抗体、编码基因、试剂盒及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
US20170204175A9 (en) 2017-07-20
RU2011117237A (ru) 2012-11-10
AR073717A1 (es) 2010-11-24
US20140314782A1 (en) 2014-10-23
EP2334331B1 (en) 2015-04-29
CA2736429A1 (en) 2010-04-08
AU2009298569A1 (en) 2010-04-08
BRPI0913827A2 (pt) 2020-12-29
EP2334331A1 (en) 2011-06-22
RU2580029C2 (ru) 2016-04-10
IL211623A0 (en) 2011-05-31
KR20110061600A (ko) 2011-06-09
MX2011002928A (es) 2011-04-11
US8404239B2 (en) 2013-03-26
PE20120080A1 (es) 2012-02-17
ES2541726T3 (es) 2015-07-23
US20140037643A1 (en) 2014-02-06
WO2010039832A1 (en) 2010-04-08
ZA201101651B (en) 2012-06-27
US20180057589A1 (en) 2018-03-01
TW201018484A (en) 2010-05-16
CL2011000711A1 (es) 2012-07-20
US20150104461A1 (en) 2015-04-16
KR101712214B1 (ko) 2017-03-03
CN102170909A (zh) 2011-08-31
US20100080808A1 (en) 2010-04-01
JP2012504634A (ja) 2012-02-23
JP5710487B2 (ja) 2015-04-30
JP2015145379A (ja) 2015-08-13

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