CN102145195B - 修复软骨损伤之外科移植物 - Google Patents
修复软骨损伤之外科移植物 Download PDFInfo
- Publication number
- CN102145195B CN102145195B CN201110034680.5A CN201110034680A CN102145195B CN 102145195 B CN102145195 B CN 102145195B CN 201110034680 A CN201110034680 A CN 201110034680A CN 102145195 B CN102145195 B CN 102145195B
- Authority
- CN
- China
- Prior art keywords
- graft
- mscs
- collagen
- chondrocyte
- lacuna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010007710 Cartilage injury Diseases 0.000 title claims abstract description 20
- 102000008186 Collagen Human genes 0.000 claims abstract description 35
- 108010035532 Collagen Proteins 0.000 claims abstract description 35
- 229920001436 collagen Polymers 0.000 claims abstract description 32
- 210000001612 chondrocyte Anatomy 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 20
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 37
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 20
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 20
- 241001484259 Lacuna Species 0.000 claims description 18
- 210000000988 bone and bone Anatomy 0.000 claims description 14
- 239000002609 medium Substances 0.000 claims description 12
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims description 10
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- 230000022159 cartilage development Effects 0.000 description 4
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- 102000000503 Collagen Type II Human genes 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 201000009859 Osteochondrosis Diseases 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
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- 206010028851 Necrosis Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 208000002804 Osteochondritis Diseases 0.000 description 1
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- 230000009816 chondrogenic differentiation Effects 0.000 description 1
- 230000002648 chondrogenic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/700,469 | 2010-02-04 | ||
| US12/700,469 US8574614B2 (en) | 2010-02-04 | 2010-02-04 | Surgical grafts for repairing chondral defects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102145195A CN102145195A (zh) | 2011-08-10 |
| CN102145195B true CN102145195B (zh) | 2015-08-26 |
Family
ID=44341891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110034680.5A Active CN102145195B (zh) | 2010-02-04 | 2011-01-30 | 修复软骨损伤之外科移植物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8574614B2 (enExample) |
| EP (1) | EP2392358B1 (enExample) |
| JP (2) | JP5764807B2 (enExample) |
| CN (1) | CN102145195B (enExample) |
| ES (1) | ES2541486T3 (enExample) |
| PT (1) | PT2392358E (enExample) |
| SG (3) | SG173284A1 (enExample) |
| TW (1) | TWI469993B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| AU2012335746B2 (en) | 2011-11-08 | 2017-04-27 | Auxocell Laboratories, Inc. | Systems and methods for processing cells |
| RU2494469C1 (ru) * | 2012-04-02 | 2013-09-27 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "ННИИТО" Минздравсоцразвития России) | Способ коррекции дефекта межпозвонкового диска в эксперименте |
| CN103387959A (zh) * | 2012-10-19 | 2013-11-13 | 夏佑红 | 一种乳牙干细胞及其制备方法和应用 |
| CN102899287B (zh) * | 2012-10-24 | 2013-08-21 | 天津和泽干细胞科技有限公司 | 一种诱导间充质干细胞向软骨细胞分化的方法及其在骨关节炎中的应用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
| US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| CN111821518B (zh) * | 2019-04-15 | 2023-01-10 | 弗元(上海)生物科技有限公司 | 一种具有再生能力的组织工程骨的制备方法 |
| CN111821519A (zh) * | 2019-04-15 | 2020-10-27 | 弗元(上海)生物科技有限公司 | 一种组织工程软骨的制备方法及其应用 |
| CN115845142B (zh) * | 2022-12-23 | 2024-08-13 | 武汉大学 | 快速修复颌骨缺损的软骨样微组织的制备方法 |
| CN116983478A (zh) * | 2023-07-31 | 2023-11-03 | 江苏博赛孚医疗科技有限公司 | 有机物包埋的聚羟基乙酸软骨支架及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| CN1868424A (zh) * | 2005-05-27 | 2006-11-29 | 中国人民解放军总医院 | 一种关节软骨原性微载体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU742638B2 (en) * | 1996-12-06 | 2002-01-10 | Mesoblast International Sarl | Improved chondrogenic differentiation of human mesenchymal stem cells |
| ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
| US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
| DE20019809U1 (de) | 2000-05-31 | 2001-07-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80636 München | Knorpelersatz und Biomatrix zur Kultivierung von Zellen |
| US20030050709A1 (en) * | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
| KR100494265B1 (ko) * | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
| US20040258731A1 (en) * | 2001-11-21 | 2004-12-23 | Tsuyoshi Shimoboji | Preparation approriate for cartilage tissue formation |
| ES2245879B1 (es) * | 2004-05-21 | 2006-12-16 | Universidad De Malaga | Composicion para la reparacion osea o cartilaginosa. |
-
2010
- 2010-02-04 US US12/700,469 patent/US8574614B2/en active Active
- 2010-06-11 TW TW99119088A patent/TWI469993B/zh active
-
2011
- 2011-01-24 SG SG2011004793A patent/SG173284A1/en unknown
- 2011-01-24 SG SG2013037825A patent/SG190660A1/en unknown
- 2011-01-24 SG SG10201402811YA patent/SG10201402811YA/en unknown
- 2011-01-27 JP JP2011015143A patent/JP5764807B2/ja active Active
- 2011-01-30 CN CN201110034680.5A patent/CN102145195B/zh active Active
- 2011-02-01 PT PT111529426T patent/PT2392358E/pt unknown
- 2011-02-01 EP EP11152942.6A patent/EP2392358B1/en active Active
- 2011-02-01 ES ES11152942.6T patent/ES2541486T3/es active Active
-
2015
- 2015-01-15 JP JP2015006164A patent/JP2015091401A/ja not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| CN1868424A (zh) * | 2005-05-27 | 2006-11-29 | 中国人民解放军总医院 | 一种关节软骨原性微载体 |
Non-Patent Citations (1)
| Title |
|---|
| In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration;T.Y. Hui 等;《Biomaterials》;20080831;第29卷(第22期);参见第3201-3210页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8574614B2 (en) | 2013-11-05 |
| EP2392358A2 (en) | 2011-12-07 |
| CN102145195A (zh) | 2011-08-10 |
| TW201127851A (en) | 2011-08-16 |
| SG10201402811YA (en) | 2014-07-30 |
| TWI469993B (zh) | 2015-01-21 |
| EP2392358A3 (en) | 2012-04-04 |
| SG190660A1 (en) | 2013-06-28 |
| JP5764807B2 (ja) | 2015-08-19 |
| US20110189254A1 (en) | 2011-08-04 |
| SG173284A1 (en) | 2011-08-29 |
| ES2541486T3 (es) | 2015-07-21 |
| JP2015091401A (ja) | 2015-05-14 |
| PT2392358E (pt) | 2015-08-26 |
| JP2011161225A (ja) | 2011-08-25 |
| EP2392358B1 (en) | 2015-04-08 |
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