TWI469993B - 修復軟骨損傷之外科移植物 - Google Patents
修復軟骨損傷之外科移植物 Download PDFInfo
- Publication number
- TWI469993B TWI469993B TW99119088A TW99119088A TWI469993B TW I469993 B TWI469993 B TW I469993B TW 99119088 A TW99119088 A TW 99119088A TW 99119088 A TW99119088 A TW 99119088A TW I469993 B TWI469993 B TW I469993B
- Authority
- TW
- Taiwan
- Prior art keywords
- mscs
- collagen
- graft
- medium
- cells
- Prior art date
Links
- 230000007547 defect Effects 0.000 title description 5
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 45
- 102000008186 Collagen Human genes 0.000 claims description 41
- 108010035532 Collagen Proteins 0.000 claims description 41
- 229920001436 collagen Polymers 0.000 claims description 41
- 210000004027 cell Anatomy 0.000 claims description 37
- 210000001612 chondrocyte Anatomy 0.000 claims description 33
- 239000011159 matrix material Substances 0.000 claims description 26
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 23
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 23
- 210000000845 cartilage Anatomy 0.000 claims description 19
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 18
- 206010007710 Cartilage injury Diseases 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 241001484259 Lacuna Species 0.000 claims description 12
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 238000012258 culturing Methods 0.000 claims description 9
- 230000004069 differentiation Effects 0.000 claims description 9
- 210000001185 bone marrow Anatomy 0.000 claims description 8
- 210000000577 adipose tissue Anatomy 0.000 claims description 5
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- 210000003205 muscle Anatomy 0.000 claims description 5
- 210000002826 placenta Anatomy 0.000 claims description 4
- 210000003954 umbilical cord Anatomy 0.000 claims description 4
- 235000015110 jellies Nutrition 0.000 claims 3
- 239000008274 jelly Substances 0.000 claims 3
- 239000002609 medium Substances 0.000 description 14
- 210000000988 bone and bone Anatomy 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
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- 229940072056 alginate Drugs 0.000 description 6
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- 230000022159 cartilage development Effects 0.000 description 3
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- 102000046949 human MSC Human genes 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002804 Osteochondritis Diseases 0.000 description 2
- 201000009859 Osteochondrosis Diseases 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000003035 hyaline cartilage Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 241000220479 Acacia Species 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010018634 Gouty Arthritis Diseases 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 206010065433 Ligament rupture Diseases 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 206010072970 Meniscus injury Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 206010031264 Osteonecrosis Diseases 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
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- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009816 chondrogenic differentiation Effects 0.000 description 1
- 230000002648 chondrogenic effect Effects 0.000 description 1
- 210000001608 connective tissue cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- -1 glucosamine polysaccharide Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
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- 238000002955 isolation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
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- 230000001338 necrotic effect Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
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- 210000003689 pubic bone Anatomy 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/700,469 US8574614B2 (en) | 2010-02-04 | 2010-02-04 | Surgical grafts for repairing chondral defects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201127851A TW201127851A (en) | 2011-08-16 |
| TWI469993B true TWI469993B (zh) | 2015-01-21 |
Family
ID=44341891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW99119088A TWI469993B (zh) | 2010-02-04 | 2010-06-11 | 修復軟骨損傷之外科移植物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8574614B2 (enExample) |
| EP (1) | EP2392358B1 (enExample) |
| JP (2) | JP5764807B2 (enExample) |
| CN (1) | CN102145195B (enExample) |
| ES (1) | ES2541486T3 (enExample) |
| PT (1) | PT2392358E (enExample) |
| SG (3) | SG173284A1 (enExample) |
| TW (1) | TWI469993B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| AU2012335746B2 (en) | 2011-11-08 | 2017-04-27 | Auxocell Laboratories, Inc. | Systems and methods for processing cells |
| RU2494469C1 (ru) * | 2012-04-02 | 2013-09-27 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "ННИИТО" Минздравсоцразвития России) | Способ коррекции дефекта межпозвонкового диска в эксперименте |
| CN103387959A (zh) * | 2012-10-19 | 2013-11-13 | 夏佑红 | 一种乳牙干细胞及其制备方法和应用 |
| CN102899287B (zh) * | 2012-10-24 | 2013-08-21 | 天津和泽干细胞科技有限公司 | 一种诱导间充质干细胞向软骨细胞分化的方法及其在骨关节炎中的应用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
| US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| CN111821518B (zh) * | 2019-04-15 | 2023-01-10 | 弗元(上海)生物科技有限公司 | 一种具有再生能力的组织工程骨的制备方法 |
| CN111821519A (zh) * | 2019-04-15 | 2020-10-27 | 弗元(上海)生物科技有限公司 | 一种组织工程软骨的制备方法及其应用 |
| CN115845142B (zh) * | 2022-12-23 | 2024-08-13 | 武汉大学 | 快速修复颌骨缺损的软骨样微组织的制备方法 |
| CN116983478A (zh) * | 2023-07-31 | 2023-11-03 | 江苏博赛孚医疗科技有限公司 | 有机物包埋的聚羟基乙酸软骨支架及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| AU742638B2 (en) * | 1996-12-06 | 2002-01-10 | Mesoblast International Sarl | Improved chondrogenic differentiation of human mesenchymal stem cells |
| ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
| US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
| DE20019809U1 (de) | 2000-05-31 | 2001-07-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80636 München | Knorpelersatz und Biomatrix zur Kultivierung von Zellen |
| US20030050709A1 (en) * | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
| KR100494265B1 (ko) * | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
| US20040258731A1 (en) * | 2001-11-21 | 2004-12-23 | Tsuyoshi Shimoboji | Preparation approriate for cartilage tissue formation |
| ES2245879B1 (es) * | 2004-05-21 | 2006-12-16 | Universidad De Malaga | Composicion para la reparacion osea o cartilaginosa. |
| CN100477971C (zh) * | 2005-05-27 | 2009-04-15 | 中国人民解放军总医院 | 一种关节软骨原性微载体 |
-
2010
- 2010-02-04 US US12/700,469 patent/US8574614B2/en active Active
- 2010-06-11 TW TW99119088A patent/TWI469993B/zh active
-
2011
- 2011-01-24 SG SG2011004793A patent/SG173284A1/en unknown
- 2011-01-24 SG SG2013037825A patent/SG190660A1/en unknown
- 2011-01-24 SG SG10201402811YA patent/SG10201402811YA/en unknown
- 2011-01-27 JP JP2011015143A patent/JP5764807B2/ja active Active
- 2011-01-30 CN CN201110034680.5A patent/CN102145195B/zh active Active
- 2011-02-01 PT PT111529426T patent/PT2392358E/pt unknown
- 2011-02-01 EP EP11152942.6A patent/EP2392358B1/en active Active
- 2011-02-01 ES ES11152942.6T patent/ES2541486T3/es active Active
-
2015
- 2015-01-15 JP JP2015006164A patent/JP2015091401A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 劉華昌，利用生物活性基質進行骨軟骨及韌帶之組織工程，行政院國家科學委員會研究計畫，2007年05月29日 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8574614B2 (en) | 2013-11-05 |
| EP2392358A2 (en) | 2011-12-07 |
| CN102145195A (zh) | 2011-08-10 |
| TW201127851A (en) | 2011-08-16 |
| SG10201402811YA (en) | 2014-07-30 |
| EP2392358A3 (en) | 2012-04-04 |
| SG190660A1 (en) | 2013-06-28 |
| JP5764807B2 (ja) | 2015-08-19 |
| US20110189254A1 (en) | 2011-08-04 |
| SG173284A1 (en) | 2011-08-29 |
| ES2541486T3 (es) | 2015-07-21 |
| JP2015091401A (ja) | 2015-05-14 |
| CN102145195B (zh) | 2015-08-26 |
| PT2392358E (pt) | 2015-08-26 |
| JP2011161225A (ja) | 2011-08-25 |
| EP2392358B1 (en) | 2015-04-08 |
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