SG173284A1 - Surgical grafts for repairing chondral defects - Google Patents
Surgical grafts for repairing chondral defects Download PDFInfo
- Publication number
- SG173284A1 SG173284A1 SG2011004793A SG2011004793A SG173284A1 SG 173284 A1 SG173284 A1 SG 173284A1 SG 2011004793 A SG2011004793 A SG 2011004793A SG 2011004793 A SG2011004793 A SG 2011004793A SG 173284 A1 SG173284 A1 SG 173284A1
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- implant
- mscs
- collagen
- chondrocyte
- Prior art date
Links
- 230000007547 defect Effects 0.000 title claims abstract description 29
- 102000008186 Collagen Human genes 0.000 claims abstract description 35
- 108010035532 Collagen Proteins 0.000 claims abstract description 35
- 229920001436 collagen Polymers 0.000 claims abstract description 35
- 239000007943 implant Substances 0.000 claims abstract description 32
- 239000011159 matrix material Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 18
- 210000004027 cell Anatomy 0.000 claims description 52
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 39
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 19
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 9
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 9
- 230000004069 differentiation Effects 0.000 claims description 8
- 210000001185 bone marrow Anatomy 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 5
- 102000000503 Collagen Type II Human genes 0.000 claims description 3
- 108010041390 Collagen Type II Proteins 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 3
- 210000003074 dental pulp Anatomy 0.000 claims description 3
- 210000004700 fetal blood Anatomy 0.000 claims description 3
- 235000015110 jellies Nutrition 0.000 claims description 3
- 239000008274 jelly Substances 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 2
- 210000002826 placenta Anatomy 0.000 claims description 2
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 description 12
- 210000000845 cartilage Anatomy 0.000 description 9
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 7
- 229940072056 alginate Drugs 0.000 description 7
- 235000010443 alginic acid Nutrition 0.000 description 7
- 229920000615 alginic acid Polymers 0.000 description 7
- 210000003127 knee Anatomy 0.000 description 6
- 230000003248 secreting effect Effects 0.000 description 6
- 239000008188 pellet Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000022159 cartilage development Effects 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 229920000936 Agarose Polymers 0.000 description 3
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 3
- 201000009859 Osteochondrosis Diseases 0.000 description 3
- 238000000692 Student's t-test Methods 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000002648 chondrogenic effect Effects 0.000 description 3
- 102000046949 human MSC Human genes 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 210000003035 hyaline cartilage Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 210000002955 secretory cell Anatomy 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010018634 Gouty Arthritis Diseases 0.000 description 1
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 206010065433 Ligament rupture Diseases 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 206010072970 Meniscus injury Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 101100439111 Rattus norvegicus Cebpd gene Proteins 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009816 chondrogenic differentiation Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000002894 multi-fate stem cell Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 208000007656 osteochondritis dissecans Diseases 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 210000003314 quadriceps muscle Anatomy 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/700,469 US8574614B2 (en) | 2010-02-04 | 2010-02-04 | Surgical grafts for repairing chondral defects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG173284A1 true SG173284A1 (en) | 2011-08-29 |
Family
ID=44341891
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2011004793A SG173284A1 (en) | 2010-02-04 | 2011-01-24 | Surgical grafts for repairing chondral defects |
| SG2013037825A SG190660A1 (en) | 2010-02-04 | 2011-01-24 | Surgical grafts for repairing chondral defects |
| SG10201402811YA SG10201402811YA (en) | 2010-02-04 | 2011-01-24 | Surgical grafts for repairing chondral defects |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013037825A SG190660A1 (en) | 2010-02-04 | 2011-01-24 | Surgical grafts for repairing chondral defects |
| SG10201402811YA SG10201402811YA (en) | 2010-02-04 | 2011-01-24 | Surgical grafts for repairing chondral defects |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8574614B2 (enExample) |
| EP (1) | EP2392358B1 (enExample) |
| JP (2) | JP5764807B2 (enExample) |
| CN (1) | CN102145195B (enExample) |
| ES (1) | ES2541486T3 (enExample) |
| PT (1) | PT2392358E (enExample) |
| SG (3) | SG173284A1 (enExample) |
| TW (1) | TWI469993B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| AU2012335746B2 (en) | 2011-11-08 | 2017-04-27 | Auxocell Laboratories, Inc. | Systems and methods for processing cells |
| RU2494469C1 (ru) * | 2012-04-02 | 2013-09-27 | Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "ННИИТО" Минздравсоцразвития России) | Способ коррекции дефекта межпозвонкового диска в эксперименте |
| CN103387959A (zh) * | 2012-10-19 | 2013-11-13 | 夏佑红 | 一种乳牙干细胞及其制备方法和应用 |
| CN102899287B (zh) * | 2012-10-24 | 2013-08-21 | 天津和泽干细胞科技有限公司 | 一种诱导间充质干细胞向软骨细胞分化的方法及其在骨关节炎中的应用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
| US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| CN111821518B (zh) * | 2019-04-15 | 2023-01-10 | 弗元(上海)生物科技有限公司 | 一种具有再生能力的组织工程骨的制备方法 |
| CN111821519A (zh) * | 2019-04-15 | 2020-10-27 | 弗元(上海)生物科技有限公司 | 一种组织工程软骨的制备方法及其应用 |
| CN115845142B (zh) * | 2022-12-23 | 2024-08-13 | 武汉大学 | 快速修复颌骨缺损的软骨样微组织的制备方法 |
| CN116983478A (zh) * | 2023-07-31 | 2023-11-03 | 江苏博赛孚医疗科技有限公司 | 有机物包埋的聚羟基乙酸软骨支架及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| AU742638B2 (en) * | 1996-12-06 | 2002-01-10 | Mesoblast International Sarl | Improved chondrogenic differentiation of human mesenchymal stem cells |
| ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
| US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
| DE20019809U1 (de) | 2000-05-31 | 2001-07-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80636 München | Knorpelersatz und Biomatrix zur Kultivierung von Zellen |
| US20030050709A1 (en) * | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
| KR100494265B1 (ko) * | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
| US20040258731A1 (en) * | 2001-11-21 | 2004-12-23 | Tsuyoshi Shimoboji | Preparation approriate for cartilage tissue formation |
| ES2245879B1 (es) * | 2004-05-21 | 2006-12-16 | Universidad De Malaga | Composicion para la reparacion osea o cartilaginosa. |
| CN100477971C (zh) * | 2005-05-27 | 2009-04-15 | 中国人民解放军总医院 | 一种关节软骨原性微载体 |
-
2010
- 2010-02-04 US US12/700,469 patent/US8574614B2/en active Active
- 2010-06-11 TW TW99119088A patent/TWI469993B/zh active
-
2011
- 2011-01-24 SG SG2011004793A patent/SG173284A1/en unknown
- 2011-01-24 SG SG2013037825A patent/SG190660A1/en unknown
- 2011-01-24 SG SG10201402811YA patent/SG10201402811YA/en unknown
- 2011-01-27 JP JP2011015143A patent/JP5764807B2/ja active Active
- 2011-01-30 CN CN201110034680.5A patent/CN102145195B/zh active Active
- 2011-02-01 PT PT111529426T patent/PT2392358E/pt unknown
- 2011-02-01 EP EP11152942.6A patent/EP2392358B1/en active Active
- 2011-02-01 ES ES11152942.6T patent/ES2541486T3/es active Active
-
2015
- 2015-01-15 JP JP2015006164A patent/JP2015091401A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US8574614B2 (en) | 2013-11-05 |
| EP2392358A2 (en) | 2011-12-07 |
| CN102145195A (zh) | 2011-08-10 |
| TW201127851A (en) | 2011-08-16 |
| SG10201402811YA (en) | 2014-07-30 |
| TWI469993B (zh) | 2015-01-21 |
| EP2392358A3 (en) | 2012-04-04 |
| SG190660A1 (en) | 2013-06-28 |
| JP5764807B2 (ja) | 2015-08-19 |
| US20110189254A1 (en) | 2011-08-04 |
| ES2541486T3 (es) | 2015-07-21 |
| JP2015091401A (ja) | 2015-05-14 |
| CN102145195B (zh) | 2015-08-26 |
| PT2392358E (pt) | 2015-08-26 |
| JP2011161225A (ja) | 2011-08-25 |
| EP2392358B1 (en) | 2015-04-08 |
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