CN102119774B - 一种适用于ⅱ型糖尿病患者的保健食品 - Google Patents
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Abstract
本发明公开了一种适用于II型糖尿病患者的保健食品，特别是适用于超重和肥胖II型糖尿病患者的保健食品，它由包括下述以重量份计的原料均匀混合制成：裸燕麦20～120，辣木叶粉1～15，酵母粉1～5，小麦胚芽1～5。食用方法是：以本保健食品为主食，每日两餐，40g/餐加冷水400ml煮沸1～2分钟，按糖尿病饮食管理配以副食，食用12周。本发明的优点是：原料易得、治疗费用低、无毒副作用、可降低超重和肥胖T2DM患者的体重，还有利于患者糖、脂和尿酸代谢及高INS血症的改善、脂肪肝的逆转和高血压的控制，有利于患者口服降血糖药治疗的坚持。
Description
技术领域
本发明涉及保健食品，具体是一种适用于II型糖尿病患者的保健食品，特别是适用于超重和肥胖II型糖尿病患者食用的保健食品。
背景技术
随着人们生活水平的提高，饮食结构和生活方式的改变，超重和肥胖的II型糖尿病(T2DM)患者日渐增多；且随着T2DM治疗的进程，T2DM患者的体重呈现增加趋势，血糖、血压、血脂谱等代谢指标难以达标。寻找对超重和肥胖的II型糖尿病有辅助治疗作用的食品，对减少用药费用和延缓糖尿病并发症的发生有重要意义。
发明内容
本发明的目的在于提供一种适用于II型糖尿病患者，特别是适用于超重和肥胖II型糖尿病患者食用的保健食品，该保健食品能帮助糖尿病患者的血糖、血压、血脂等代谢指标达标。
实现本发明目的的技术方案是：
一种适用于II型糖尿病患者食用的保健食品，包括下述以重量份计的原料均匀混合制成：
裸燕麦20～120份、辣木叶粉1～15份、酵母粉1～5份、小麦胚芽1～5份。
上述各原料优选的配比以重量份计为：
裸燕麦60～80份、辣木叶粉4～8份、酵母粉1～3份、小麦胚芽1-3份。
所述的裸燕麦是燕麦中的一种，主要营养成分蛋白质、脂肪(主要是不饱和脂肪酸)、碳水化合物、粗纤维、矿物质和维生物E、B1、B2，高于小麦、大米、玉米等谷类作物，同时裸燕麦还富含人体必需的8种氨基酸，尤其是对人体骨骼有增进功能的赖氨酸含量高，每100克含量达到0.68克，特别是还含有降低高胆固醇患者的低密度脂蛋白作用的β-葡聚糖和其他谷类作用的皂素；
所述的辣木叶粉是热带作物辣木的叶经粉碎而成，营养丰富，据报道，其中钙、钾、铁、镁、维生素A、C、E含量远高于奶粉和鲜牛奶，另外，辣木叶粉蛋白质和总膳食纤维含量较高，而脂肪含量偏低；
所述的酵母粉中含有丰富的蛋白质、多糖、维生素、矿物质等多种营养成分，其蛋白质含量高达40-60％；
所述的小麦胚芽又称麦芽粉、胚芽，是小麦营养价值最高部分，内含丰富的蛋白质、维生素、矿物质以及全部18种人体必需的氨基酸，是一种高蛋白、高维生素E、低热、低脂、低胆固醇的营养品。
本保健食品的食用方法为：每40mg，加水400ml-500ml，煮沸1-2分钟即可作为主食，配以副食，可长期食用。
本保健食品各原料经科学配伍后，保健作用叠加或互补，裸燕麦中的β-葡聚糖可降低血糖指数(GI)，在体内释放葡萄糖缓慢，可控制血糖平衡，减少饥饿感，其避免了餐后2小时血糖高峰值，使血糖缓慢上升，同时可以稳定、持续、长时间供给机体活动需要的能量，特别适宜肥胖和超重的糖尿病患者食用。另外，本保健食品中还含有多种有益人体健康的微量元素、矿物质、可溶和不溶性膳食纤维，特别含有一般植物如小麦、稻米所缺少的赖氨酸、精氨酸和组氨酸，可避免摄入过多的脂肪，有利于改善糖尿病血脂紊乱状况减少糖尿病患者心脑血管疾病事件的发生。本保健食品经试用，食用本保健食品的患者的体重明显降低，高血压改善，二甲双胍和磺脲类药物用量明显减少，NDR增加，GGT也明显优于未食用本保健品的患者，FINS明显低于未食用本保健食品的患者。
本发明的积极效果是：配方合理、原料易得、治疗费用低、无毒副作用，既可降低超重和肥胖T2DM患者的体重，还有利于患者糖、脂和尿酸代谢及高INS血症的改善、脂肪肝的逆转和高血压的控制，有利于患者口服降血糖药治疗的坚持。
具体实施方式
下面结合实施例对本发明作进一步的阐述，但应理解以下的实施例仅用于对本发明进行说明，而并非用以限定本发明的保护范围。
下表实施例中各组份原料用量为重量份：
所述的裸燕麦、辣木叶粉、酵母粉和小麦胚芽从市场上购得。
本发明产品经桂林市中医院临床验证，试验情况如下：
1、对象
选择2009年3月至2010年3月在糖尿病科门诊和住院的30-60岁的超重和肥胖的T2DM患者120例，符合1999年WHO糖尿病诊断和分类标准，BMI≥25kg/m2。入组患者无明显脑血管意外的神经系统定位症状，普通心电图检查无明显心肌缺血或心肌梗死，无大量蛋白尿和肾功能不全，无增殖型视网膜病变。
2、方法
所有患者依就诊次序随机分为A、B两组，均进行糖尿病宣教，运动疗法，口服降血糖药物以二甲双胍治疗为主、磺脲类药物治疗为辅(格列苯脲每片2.5mg或格列吡嗪每片5mg或格列喹酮30mg或格列齐特缓释片每片30mg)；A组患者食用本保健食品40g/餐加冷水400毫升煮沸1-2分钟为主食，按糖尿病饮食管理配以副食，2餐/日；B组患者则采用普通糖尿病饮食。所有患者每2周调整口服降血糖药物1次，同时检查患者的依从性，于0、12周测量患者的血压(Bp)并计算Bp降低值、体重下降净值(WLV)和下降百分数(WLP，即WLV÷0周体重×100％)、空腹血糖(FBG)、空腹胰岛素(FINS)、HbAlc、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血尿酸(BUA)、r-谷氨酰转肽酶(GGT)，于12周统计患者的用药情况。
3、统计学分析
统计数据用x±s表示，组间差异比较用t或t’检验，组间男女比值和百分率的比较用X2分析。
4、结果
(1)两组患者治疗前的临床和实验室资料
两组间年龄、糖尿病病程、男女比值和试验前的体重、BMI、Bp、糖、脂和尿酸代谢等情况差异无显著意义(P＞0.05)，有可比性，详见表1。
(2)两组患者治疗后的临床和实验室资料
由表2可见，A组患者的体重、Bp、二甲双胍及磺脲类药物用量明显低于B组(p＜0.02)，而停药率(NDR，仅用饮食和运动治疗血糖指标即达正常者的百分率)则明显高于B组(p＜0.01)；A组患者的WLV和WLP明显增加，而B组则呈轻微负增长，两组比较差异有非常显著意义(p＜0.01)。A组患者的糖、脂蛋白和尿酸代谢的改善程度明显优于B(p＜0.05)；FINS、TG和GGT也明显低于B组(p＜0.02)。
表1两组患者治疗前的临床和实验室资料(x±s)
表1(续表)
注：两组比较P均＞0.05，差异无显著意义。
表2两组患者治疗后的临床和实验室资料(x±s)
表2(续表)
注：A组与B组比较*P＜0.01，△P＜0.05。
试验结果表明：本发明可明显减轻超重和肥胖T2DM患者的体重，更有利于患者糖、脂和尿酸代谢及高INS血症的改善、脂肪肝的逆转和高血压的控制，也有利于患者口服降血糖药治疗的坚持。
Claims (2)
1.一种适用于II型糖尿病患者的保健食品，其特征是：由下述以重量份计的原料均匀混合制成：
裸燕麦 60～120份、辣木粉 1～15份、酵母粉 1～5份、小麦胚芽 1～5份。
2.根据权利要求1所述的保健食品，其特征是：由下述以重量份计的原料制成：
裸燕麦 60～80份、辣木粉 4～8份、酵母粉 1～3份、小麦胚芽 1～3份。
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| WO2013106945A1 (zh) * | 2012-01-16 | 2013-07-25 | Li Yong | 能调控血糖和胰岛素抵抗水平的有机全胚芽裸燕麦 |
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| CN107149082A (zh) * | 2016-03-02 | 2017-09-12 | 上海宣泰生物科技有限公司 | 一种防治糖尿病的高抗性淀粉含量米粉的组合物 |
| CN106701404B (zh) * | 2016-11-28 | 2020-05-12 | 西华大学 | 一种辣木叶燕麦营养酒及其制备方法 |
| CN109430721A (zh) * | 2018-10-17 | 2019-03-08 | 广州市好孝心医疗器械有限公司 | 一种具有降血糖作用的小麦胚芽组合物及其制备方法 |
| CN112262989A (zh) * | 2020-11-04 | 2021-01-26 | 光瀚健康咨询管理(上海)有限公司 | 一种蛋白控糖代餐粉及其制备方法 |
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