CN1021051C - 新型的噻吩衍生物的制备方法 - Google Patents

新型的噻吩衍生物的制备方法 Download PDF

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Publication number
CN1021051C
CN1021051C CN88104039A CN88104039A CN1021051C CN 1021051 C CN1021051 C CN 1021051C CN 88104039 A CN88104039 A CN 88104039A CN 88104039 A CN88104039 A CN 88104039A CN 1021051 C CN1021051 C CN 1021051C
Authority
CN
China
Prior art keywords
formula
compound
mixture
thienyl
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN88104039A
Other languages
English (en)
Chinese (zh)
Other versions
CN1030584A (zh
Inventor
林公明
尾崎秦彦
山田健二
竹永秀幸
井上一三
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of CN1030584A publication Critical patent/CN1030584A/zh
Application granted granted Critical
Publication of CN1021051C publication Critical patent/CN1021051C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Dowels (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN88104039A 1987-06-30 1988-06-28 新型的噻吩衍生物的制备方法 Expired - Fee Related CN1021051C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP164837/87 1987-06-30
JP16483787 1987-06-30

Publications (2)

Publication Number Publication Date
CN1030584A CN1030584A (zh) 1989-01-25
CN1021051C true CN1021051C (zh) 1993-06-02

Family

ID=15800866

Family Applications (1)

Application Number Title Priority Date Filing Date
CN88104039A Expired - Fee Related CN1021051C (zh) 1987-06-30 1988-06-28 新型的噻吩衍生物的制备方法

Country Status (16)

Country Link
US (1) US4857543A (cg-RX-API-DMAC10.html)
EP (1) EP0297782B1 (cg-RX-API-DMAC10.html)
JP (1) JPS6479175A (cg-RX-API-DMAC10.html)
KR (1) KR890000457A (cg-RX-API-DMAC10.html)
CN (1) CN1021051C (cg-RX-API-DMAC10.html)
AT (1) ATE63746T1 (cg-RX-API-DMAC10.html)
AU (1) AU599495B2 (cg-RX-API-DMAC10.html)
CA (1) CA1320964C (cg-RX-API-DMAC10.html)
DE (1) DE3862901D1 (cg-RX-API-DMAC10.html)
DK (1) DK358088A (cg-RX-API-DMAC10.html)
ES (1) ES2040856T3 (cg-RX-API-DMAC10.html)
FI (1) FI882873A7 (cg-RX-API-DMAC10.html)
FR (1) FR2617402B1 (cg-RX-API-DMAC10.html)
GR (1) GR3001994T3 (cg-RX-API-DMAC10.html)
HU (1) HU203338B (cg-RX-API-DMAC10.html)
IL (1) IL86740A (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
FR2658822A1 (fr) * 1990-02-28 1991-08-30 Jouveinal Sa N-cycloalkylalkylamines, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
HU215430B (hu) * 1990-02-26 1999-09-28 Parke-Davis Eljárás N-cikloalkil-alkil-amin-származékok, valamint hatóanyagként e vegyületeket tartalmazó gyógyászati készítmények előállítására
FR2658817B1 (fr) * 1990-02-28 1993-02-05 Jouveinal Sa Ethylamines substituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
EP0446097A1 (fr) * 1990-02-26 1991-09-11 Jouveinal S.A. Ethylamines substituées, leur procédé de préparation, leur utilisation comme médicament et leurs intermédiaires de synthèse
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
JPH06509090A (ja) * 1991-07-10 1994-10-13 メルク　シヤープ　エンド　ドーム　リミテツド 芳香族化合物、それらを含む組成物、及び治療におけるそれらの使用
GB9211193D0 (en) * 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
AU2001269503B2 (en) 2000-07-13 2005-02-17 Sankyo Company, Limited Amino alcohol derivatives
CN100415735C (zh) * 2000-07-13 2008-09-03 三共株式会社 氨基醇衍生物
BR0306811A (pt) 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
CN110407703A (zh) * 2019-08-02 2019-11-05 深圳振强生物技术有限公司 吲哚布芬杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122561A (en) * 1959-10-19 1964-02-25 Tuskegee Inst 1-(2-thenyl)-2-di-lower alkylaminoethyl diphenylacetate and related compounds
GB1343527A (en) * 1971-07-30 1974-01-10 Cerm Cent Europ Rech Mauvernay Amino-propanol derivatives
US4128551A (en) * 1976-12-06 1978-12-05 The Dow Chemical Co. Substituted pyridine carboxyl halides and derivatives
JPS58105946A (ja) * 1981-12-18 1983-06-24 Tanabe Seiyaku Co Ltd アミノブタノ−ルエステル誘導体の製法

Also Published As

Publication number Publication date
CA1320964C (en) 1993-08-03
FR2617402B1 (fr) 1991-07-12
AU1853488A (en) 1989-01-05
FR2617402A1 (fr) 1989-01-06
HUT50160A (en) 1989-12-28
FI882873L (fi) 1988-12-31
HU203338B (en) 1991-07-29
EP0297782B1 (en) 1991-05-22
JPH0546343B2 (cg-RX-API-DMAC10.html) 1993-07-13
FI882873A0 (fi) 1988-06-16
ATE63746T1 (de) 1991-06-15
GR3001994T3 (en) 1992-11-23
EP0297782A1 (en) 1989-01-04
DK358088D0 (da) 1988-06-29
JPS6479175A (en) 1989-03-24
IL86740A0 (en) 1988-11-30
IL86740A (en) 1992-11-15
DK358088A (da) 1988-12-31
DE3862901D1 (de) 1991-06-27
ES2040856T3 (es) 1993-11-01
US4857543A (en) 1989-08-15
CN1030584A (zh) 1989-01-25
AU599495B2 (en) 1990-07-19
FI882873A7 (fi) 1988-12-31
KR890000457A (ko) 1989-03-14

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee