CN102083855A - 活性延长的新胰岛素类似物 - Google Patents

活性延长的新胰岛素类似物 Download PDF

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Publication number
CN102083855A
CN102083855A CN2009801261044A CN200980126104A CN102083855A CN 102083855 A CN102083855 A CN 102083855A CN 2009801261044 A CN2009801261044 A CN 2009801261044A CN 200980126104 A CN200980126104 A CN 200980126104A CN 102083855 A CN102083855 A CN 102083855A
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CN
China
Prior art keywords
general formula
insulin
b32arg
b31arg
group represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN2009801261044A
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English (en)
Chinese (zh)
Inventor
W·斯瓦温斯基
P·博罗维奇
A·普罗辛尼奇扎克
J·米科瓦伊奇克
T·格拉宾斯基
D·库日诺加
D·米基维奇-西格瓦
A·舞伊托维奇-克拉维茨
M·杰林斯基
M·凯希克-布罗达卡
V·亚当切夫斯卡-切库达
I·索科沃夫斯卡
G·普罗辛尼奇扎克
D·斯塔德尼克
J·安托西克
J·普什佐霍
J·贝尔纳特
T·帕夫卢科维奇
J·斯滕波尼夫斯基
M·博吉尔
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INST BIOTECHNOLOGII I ANTYBIOT
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INST BIOTECHNOLOGII I ANTYBIOT
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Application filed by INST BIOTECHNOLOGII I ANTYBIOT filed Critical INST BIOTECHNOLOGII I ANTYBIOT
Publication of CN102083855A publication Critical patent/CN102083855A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801261044A 2008-07-04 2009-07-04 活性延长的新胰岛素类似物 Pending CN102083855A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL385586A PL219335B1 (pl) 2008-07-04 2008-07-04 Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
PL385586 2008-07-04
PCT/PL2009/050010 WO2010002283A2 (en) 2008-07-04 2009-07-04 New insulin analogues of prolonged activity

Publications (1)

Publication Number Publication Date
CN102083855A true CN102083855A (zh) 2011-06-01

Family

ID=41130257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801261044A Pending CN102083855A (zh) 2008-07-04 2009-07-04 活性延长的新胰岛素类似物

Country Status (8)

Country Link
US (2) US8618048B2 (https=)
EP (2) EP2321344A2 (https=)
JP (1) JP2011526886A (https=)
CN (1) CN102083855A (https=)
CA (1) CA2729938C (https=)
EA (1) EA023559B1 (https=)
PL (2) PL219335B1 (https=)
WO (1) WO2010002283A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105025919A (zh) * 2013-01-15 2015-11-04 费斯生物制药公司 用于血糖控制的治疗剂、组合物和方法
CN110198722A (zh) * 2016-11-21 2019-09-03 卡斯西部储备大学 稳定性增强的快速作用的胰岛素类似物

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US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
ES2477880T3 (es) 2008-12-15 2014-07-18 Zealand Pharma A/S Análogos del glucagón
JP5635531B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
CN102282167B (zh) 2008-12-15 2014-08-13 西兰制药公司 胰高血糖素类似物
EP2370462B1 (en) 2008-12-15 2014-07-16 Zealand Pharma A/S Glucagon analogues
AU2010272944B2 (en) 2009-07-13 2015-11-19 Zealand Pharma A/S Acylated glucagon analogues
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
US9169310B2 (en) 2010-06-24 2015-10-27 Zealand Pharma A/S Glucagon analogues
KR20140043709A (ko) 2011-01-20 2014-04-10 질랜드 파마 에이/에스 아실화 글루카곤 유사체와 인슐린 유사체의 조합
WO2012115638A1 (en) * 2011-02-23 2012-08-30 Elona Biotechnologies Glargine proinsulin compositions and methods of producing glargine insulin analogs therefrom
IN2014MN02304A (https=) 2012-05-03 2015-08-07 Zealand Pharma As
PL222975B1 (pl) * 2012-05-23 2016-09-30 Inst Biotechnologii I Antybiotyków Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
EP2877200B1 (en) * 2012-07-17 2019-05-08 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
IN2015DN00544A (https=) 2012-07-23 2015-06-26 Zealand Pharma As
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
CN103981242A (zh) * 2013-02-07 2014-08-13 华凌科技有限公司 胰岛素的制备方法
WO2014122653A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin
WO2014122651A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin
CN103981243A (zh) * 2013-02-07 2014-08-13 华凌科技有限公司 胰岛素的制备方法
PL3057984T3 (pl) 2013-10-17 2018-12-31 Zealand Pharma A/S Acylowane analogi glukagonu
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
WO2015067715A2 (en) 2013-11-06 2015-05-14 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
CN105829339B (zh) 2013-11-06 2021-03-12 西兰制药公司 胰高血糖素-glp-1-gip三重激动剂化合物
KR102620911B1 (ko) 2014-10-29 2024-01-05 질랜드 파마 에이/에스 Gip 효능제 화합물 및 방법
DK3283507T3 (da) 2015-04-16 2020-01-02 Zealand Pharma As Acyleret glucagonanalog
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
KR102666154B1 (ko) * 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
KR20210102347A (ko) * 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
WO2021081335A1 (en) * 2019-10-24 2021-04-29 University Of Utah Research Foundation Novel mini-insulin with extended c-terminal a chain

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
WO2004111244A2 (en) * 2003-06-17 2004-12-23 Sembiosys Genetics Inc. Methods for the production of insulin in plants
WO2006096079A2 (en) * 2005-03-10 2006-09-14 Instytut Biotechnologii I Antybiotykow Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus.
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins

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DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US5434247A (en) * 1986-10-10 1995-07-18 Board Of Regents, The University Of Texas System Peptides for inducing monocyte cytotoxicity in diagnostics
US5135736A (en) * 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
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AU762351B2 (en) * 1999-01-06 2003-06-26 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
US6777207B2 (en) * 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
PL213561B1 (pl) 2004-01-09 2013-03-29 Inst Biotechnologii I Antybiotykow Sposób otrzymywania plazmidu, plazmid oraz zastosowania
US7893197B2 (en) * 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
US7947645B2 (en) * 2004-09-02 2011-05-24 Cognosci, Inc. APO E analogs and methods for their use
NZ564359A (en) * 2005-06-17 2011-09-30 Mannkind Corp Analogs of pepetides corresponding to class I MHC-restricted T cell epitopes
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
JP2009530243A (ja) * 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス アシル化単鎖インスリン
CN101573133B (zh) * 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素

Patent Citations (6)

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EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
US5506202A (en) * 1988-12-29 1996-04-09 Hoechst Aktiengesellschaft Insulin derivatives, a process for the preparation thereof, the use thereof, and a pharmaceutical formulation containing them
WO2004111244A2 (en) * 2003-06-17 2004-12-23 Sembiosys Genetics Inc. Methods for the production of insulin in plants
WO2006096079A2 (en) * 2005-03-10 2006-09-14 Instytut Biotechnologii I Antybiotykow Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus.
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
WO2008049931A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105025919A (zh) * 2013-01-15 2015-11-04 费斯生物制药公司 用于血糖控制的治疗剂、组合物和方法
CN110198722A (zh) * 2016-11-21 2019-09-03 卡斯西部储备大学 稳定性增强的快速作用的胰岛素类似物

Also Published As

Publication number Publication date
PL2371853T3 (pl) 2018-06-29
WO2010002283A3 (en) 2010-04-29
CA2729938C (en) 2018-11-06
EA023559B1 (ru) 2016-06-30
WO2010002283A9 (en) 2011-01-20
EA201170149A1 (ru) 2011-06-30
US20140121353A1 (en) 2014-05-01
US20110136736A1 (en) 2011-06-09
EP2321344A2 (en) 2011-05-18
US8618048B2 (en) 2013-12-31
WO2010002283A2 (en) 2010-01-07
EP2371853A2 (en) 2011-10-05
CA2729938A1 (en) 2010-01-07
EP2371853A3 (en) 2012-10-03
JP2011526886A (ja) 2011-10-20
PL385586A1 (pl) 2010-01-18
PL219335B1 (pl) 2015-04-30
EP2371853B1 (en) 2017-09-13

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SE01 Entry into force of request for substantive examination
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Application publication date: 20110601