CN102083741B - pH敏感性金属纳米粒子及其制造方法 - Google Patents
pH敏感性金属纳米粒子及其制造方法 Download PDFInfo
- Publication number
- CN102083741B CN102083741B CN200980125951.9A CN200980125951A CN102083741B CN 102083741 B CN102083741 B CN 102083741B CN 200980125951 A CN200980125951 A CN 200980125951A CN 102083741 B CN102083741 B CN 102083741B
- Authority
- CN
- China
- Prior art keywords
- metal nanoparticle
- compound
- sensitive
- metal
- described compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0093—Purging against cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0285—Nanoscale sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080064270A KR101014246B1 (ko) | 2008-07-03 | 2008-07-03 | 페하 민감성 금속 나노 입자 및 이의 제조 방법. |
| KR10-2008-0064270 | 2008-07-03 | ||
| PCT/KR2009/003640 WO2010002217A2 (ko) | 2008-07-03 | 2009-07-03 | 페하 민감성 금속 나노 입자 및 이의 제조 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102083741A CN102083741A (zh) | 2011-06-01 |
| CN102083741B true CN102083741B (zh) | 2015-11-25 |
Family
ID=41466491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980125951.9A Expired - Fee Related CN102083741B (zh) | 2008-07-03 | 2009-07-03 | pH敏感性金属纳米粒子及其制造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9616122B2 (https=) |
| EP (1) | EP2308799B1 (https=) |
| JP (1) | JP5577329B2 (https=) |
| KR (1) | KR101014246B1 (https=) |
| CN (1) | CN102083741B (https=) |
| WO (1) | WO2010002217A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101196667B1 (ko) * | 2010-04-15 | 2012-11-02 | 포항공과대학교 산학협력단 | 피에이치 민감성 금속 나노 입자를 이용한 항암제 전달 시스템 |
| KR101276693B1 (ko) * | 2010-10-29 | 2013-06-19 | 포항공과대학교 산학협력단 | 양쪽성 이온을 가진 나노입자 표면 개질용 표면 분자체의 합성과 그 응용 |
| KR101368179B1 (ko) * | 2010-11-12 | 2014-03-03 | 포항공과대학교 산학협력단 | 강한 전하를 가지는 나노입자 표면 분자체와 이를 이용한 생접합 및 층상 자기조립 방법 |
| WO2012174287A1 (en) * | 2011-06-15 | 2012-12-20 | The Board Of Regents Of The University Of Texas System | Luminescent nanoparticle compositions |
| US20130189367A1 (en) * | 2011-07-29 | 2013-07-25 | University Of Washington Through Its Center For Commercialization | Nanovectors for targeted gene silencing and cytotoxic effect in cancer cells |
| CN102989016A (zh) * | 2012-11-05 | 2013-03-27 | 浙江大学 | 一种具有pH敏感性的纳米微粒材料及其制备方法 |
| KR20140092430A (ko) * | 2012-12-26 | 2014-07-24 | 삼성전자주식회사 | 나노입자 조립체, 이의 제조방법 및 이를 포함하는 활성물질 전달 복합체 |
| US9784730B2 (en) | 2013-03-21 | 2017-10-10 | University Of Washington Through Its Center For Commercialization | Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine |
| US9874554B1 (en) | 2014-07-16 | 2018-01-23 | Verily Life Sciences Llc | Aptamer-based in vivo diagnostic system |
| CN104667301B (zh) * | 2015-02-12 | 2017-08-22 | 东北师范大学 | 一种单分散核壳结构AuNCs‑A@CaP纳米粒子的制备方法及其应用 |
| JP2019512486A (ja) * | 2016-03-08 | 2019-05-16 | チルドレンズ ナショナル メディカル センターChildren’S National Medical Center | 官能化されたプルシアンブルーナノ粒子、組合せプルシアンブルーナノ粒子ベースのナノ免疫療法およびその適用 |
| CN107941778A (zh) * | 2017-10-11 | 2018-04-20 | 南方医科大学南方医院 | 一种用于检测体液pH的传感器及其制备和应用方法 |
| CN111514308B (zh) * | 2020-03-10 | 2023-02-17 | 西南民族大学 | pH诱导电荷翻转型抗菌金纳米棒及其制备方法和应用 |
| CN113899732B (zh) * | 2021-09-30 | 2023-09-22 | 航天科工(长沙)新材料研究院有限公司 | pH值敏感型配体修饰纳米金及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020103517A1 (en) * | 2000-02-08 | 2002-08-01 | West Jennifer L. | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340527C (en) * | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
| DE60115667T2 (de) | 2000-09-05 | 2006-08-24 | Centelion | Säureempfindliche verbindungen, deren herstellung und verwendungen |
| GB0321937D0 (en) | 2003-09-19 | 2003-10-22 | Univ Liverpool | Nanoparticle conjugates and method of production thereof |
| US7601331B2 (en) * | 2004-11-10 | 2009-10-13 | National University Of Singapore | NIR-sensitive nanoparticle |
| KR100645597B1 (ko) | 2005-03-24 | 2006-11-14 | 이지로보틱스 주식회사 | 로봇 리모컨 서비스 방법 및 장치 |
| KR100713745B1 (ko) * | 2006-02-27 | 2007-05-07 | 연세대학교 산학협력단 | 상전이 리간드로 코팅된 수용성 자성 또는 금속 산화물나노입자 및 이의 제조방법 |
| KR20080008668A (ko) | 2006-07-20 | 2008-01-24 | 재단법인서울대학교산학협력재단 | 자성체 나노입자를 이용하여 단백질을 선택적으로 결합,분리 또는 정제하는 방법 |
| KR100802080B1 (ko) | 2007-03-28 | 2008-02-11 | 성균관대학교산학협력단 | pH 민감성 블록 공중합체 및 이를 이용한 고분자 마이셀 |
-
2008
- 2008-07-03 KR KR1020080064270A patent/KR101014246B1/ko active Active
-
2009
- 2009-07-03 WO PCT/KR2009/003640 patent/WO2010002217A2/ko not_active Ceased
- 2009-07-03 JP JP2011516156A patent/JP5577329B2/ja not_active Expired - Fee Related
- 2009-07-03 CN CN200980125951.9A patent/CN102083741B/zh not_active Expired - Fee Related
- 2009-07-03 EP EP09773753.0A patent/EP2308799B1/en active Active
- 2009-07-03 US US13/002,476 patent/US9616122B2/en active Active
-
2017
- 2017-02-21 US US15/438,698 patent/US20170226474A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020103517A1 (en) * | 2000-02-08 | 2002-08-01 | West Jennifer L. | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
Non-Patent Citations (8)
| Title |
|---|
| A General Strategy Toward pH-Controlled Aggregation–Dispersion of Gold Nanoparticles and Single-Walled Carbon Nanotubes;Xiaogang Han et al.;《small》;20080213;第4卷(第3期);第326-329页 * |
| A Protein Nanocarrier from Charge-Conversion Polymer in Response to Endosomal pH;Yan Lee et al.;《J. AM. CHEM. SOC.》;20070405;第129卷;第5362-5363页 * |
| Enhanced Intracellular Delivery of Quantum Dot and Adenovirus Nanoparticles Triggered by Acidic pH via Surface Charge Reversal;Hyejung Mok et al.;《Bioconjugate Chemistry》;20080326;第19卷(第4期);第797-801页 * |
| Gold Nanoparticles Protected with pH and Temperature-Sensitive Diblock Copolymers;Markus Nuopponen et al.;《Langmuir》;20070413;第23卷;第5352-5357页 * |
| Modulation of in Vivo Tumor Radiation Response via Gold Nanoshell-Mediated Vascular-Focused Hyperthermia: Characterizing an Integrated Antihypoxic and Localized Vascular Disrupting Targeting Strategy;Parmeswaran Diagaradjane et al.;《NANO LETTERS》;20080416;第8卷(第5期);第1492-1500页 * |
| Peiwen Zheng et al..Formation of GoldPolymer Core-Shell Particles and Gold Particle Clusters on a Template of Thermoresponsive and pH-Responsive Coordination Triblock Copolymer.《Langmuir》.2006,第22卷第9393-9396页. * |
| Reversible aggregation of gold nanoparticles induced by pH dependent conformational transitions of a self-assembled polypeptide;Jeung-Yeop Shim et al.;《Journal of Colloid and Interface Science》;20070814;第316卷;第977-983页 * |
| Synthesis and Grafting of Thioctic Acid-PEG-Folate Conjugates onto Au Nanoparticles for Selective Targeting of Folate Receptor-Positive Tumor Cells;Vivechana Dixit et al.;《Bioconjugate Chem.》;20060503;第17卷;第603-609页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100004220A (ko) | 2010-01-13 |
| EP2308799B1 (en) | 2017-11-08 |
| KR101014246B1 (ko) | 2011-02-16 |
| JP2011526883A (ja) | 2011-10-20 |
| US20170226474A1 (en) | 2017-08-10 |
| WO2010002217A2 (ko) | 2010-01-07 |
| US9616122B2 (en) | 2017-04-11 |
| JP5577329B2 (ja) | 2014-08-20 |
| WO2010002217A3 (ko) | 2010-06-24 |
| EP2308799A4 (en) | 2014-12-17 |
| CN102083741A (zh) | 2011-06-01 |
| US20110269170A1 (en) | 2011-11-03 |
| EP2308799A2 (en) | 2011-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102083741B (zh) | pH敏感性金属纳米粒子及其制造方法 | |
| Singh et al. | Carbon quantum dots: Synthesis, characterization and biomedical applications | |
| Liang et al. | Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment | |
| Chang et al. | Self-assembled CeVO 4/Ag nanohybrid as photoconversion agents with enhanced solar-driven photocatalysis and NIR-responsive photothermal/photodynamic synergistic therapy performance | |
| Hou et al. | UV-emitting upconversion-based TiO2 photosensitizing nanoplatform: near-infrared light mediated in vivo photodynamic therapy via mitochondria-involved apoptosis pathway | |
| Cui et al. | Amphiphilic chitosan modified upconversion nanoparticles for in vivo photodynamic therapy induced by near-infrared light | |
| Song et al. | Design of Near Infrared Light‐Powered Copper Phyllosilicate Nanomotors for Cuproptosis‐Based Synergistic Cancer Therapy | |
| CN105969331B (zh) | 一种适用于靶向药物载体的纳米材料的制备方法 | |
| Rita Kakkar | ZnO quantum dots for biomedical applications | |
| CN107184978B (zh) | 一种硫化铜@介孔二氧化硅纳米复合材料及其制备方法和用途 | |
| CN101775280B (zh) | 一种水溶性核壳磁光双功能纳米粒子及其制备方法 | |
| Molaei | Turmeric-derived gadolinium-doped carbon quantum dots for multifunctional fluorescence imaging and MRI contrast agent | |
| CN113817469B (zh) | 一种生物窗口内激发/发射的超亮单色上转换纳米探针及其制备方法和应用 | |
| CN104027806A (zh) | 一种修饰CuS纳米粒子的介孔二氧化硅包覆四氧化三锰的纳米材料及其制备方法和应用 | |
| Kumar et al. | In vitro and bioimaging studies of mesoporous silica nanocomposites encapsulated iron-oxide and loaded doxorubicin drug (DOX/IO@ Silica) as magnetically guided drug delivery system | |
| CN108175859B (zh) | 一种多模磁光热诊疗一体化纳米探针及其制备方法和应用 | |
| CN116041247B (zh) | 一种光热试剂、光热试剂纳米颗粒及其制备方法 | |
| CN114209825A (zh) | 亚铜离子响应的no释放和光热协同治疗剂及其应用 | |
| KR101731140B1 (ko) | 멜라닌 나노입자를 포함하는 광음향 영상화제 | |
| CN107158381A (zh) | 一种具有光热增强效应的金纳米星@硫化铜光热探针的制备方法及其应用 | |
| CN106913871B (zh) | 一种用作肿瘤光热消融诊疗剂的铂铜纳米晶及制备方法 | |
| KR101001906B1 (ko) | 페하 민감성 화합물 및 그 제조 방법 | |
| Mikalauskaite et al. | Designing red-fluorescent superparamagnetic nanoparticles by conjugation with gold clusters | |
| TWI459965B (zh) | 生物可相容的糖花狀金奈米粒子、其製備方法及其生物醫學應用 | |
| Ilie-Mihai et al. | Carbon Nanodots in Nanobiomedicines and Electrochemical Sensing Devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20180703 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |