CN102076855A - 具有延长的体内半衰期的因子viii，冯·维勒布兰德因子或它们的复合物 - Google Patents

具有延长的体内半衰期的因子viii，冯·维勒布兰德因子或它们的复合物 Download PDF

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Publication number
CN102076855A
CN102076855A CN200980123818XA CN200980123818A CN102076855A CN 102076855 A CN102076855 A CN 102076855A CN 200980123818X A CN200980123818X A CN 200980123818XA CN 200980123818 A CN200980123818 A CN 200980123818A CN 102076855 A CN102076855 A CN 102076855A
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modified
fviii
vwf
complex
polypeptide
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Chinese (zh)
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T·魏默
S·舒尔特
H·米兹尼尔
U·克龙塞勒
H·林德
W·朗
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CSL Behring GmbH Deutschland
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CSL Behring GmbH Deutschland
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Priority to CN201310596839.1A priority Critical patent/CN103739712B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200980123818XA 2008-06-24 2009-06-24 具有延长的体内半衰期的因子viii，冯·维勒布兰德因子或它们的复合物 Pending CN102076855A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310596839.1A CN103739712B (zh) 2008-06-24 2009-06-24 具有延长的体内半衰期的因子viii、冯·维勒布兰德因子或它们的复合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08011429.1 2008-06-24
EP08011429 2008-06-24
PCT/EP2009/004549 WO2009156137A1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

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CN102076855A true CN102076855A (zh) 2011-05-25

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CN200980123818XA Pending CN102076855A (zh) 2008-06-24 2009-06-24 具有延长的体内半衰期的因子viii，冯·维勒布兰德因子或它们的复合物
CN201310596839.1A Expired - Fee Related CN103739712B (zh) 2008-06-24 2009-06-24 具有延长的体内半衰期的因子viii、冯·维勒布兰德因子或它们的复合物

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US (2) US8575104B2 (https=)
EP (2) EP2291523B1 (https=)
JP (1) JP5832285B2 (https=)
KR (2) KR101648734B1 (https=)
CN (2) CN102076855A (https=)
AU (1) AU2009262476C1 (https=)
CA (1) CA2728012C (https=)
DK (2) DK2291523T3 (https=)
ES (2) ES2531464T3 (https=)
PL (1) PL2291523T3 (https=)
RU (1) RU2528855C2 (https=)
WO (1) WO2009156137A1 (https=)

Cited By (11)

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CN105392495A (zh) * 2013-06-28 2016-03-09 比奥根Ma公司 具有xten的凝血酶可裂解连接子和其用途
CN106456718A (zh) * 2014-01-10 2017-02-22 比奥根Ma公司 因子viii嵌合蛋白及其用途
CN106659771A (zh) * 2014-07-02 2017-05-10 杰特有限公司 修饰的von Willebrand因子
CN108779165A (zh) * 2016-01-07 2018-11-09 瑞士杰特贝林重组设备有限公司 突变的冯·维勒布兰德因子
CN109111526A (zh) * 2012-01-12 2019-01-01 比奥贝拉蒂治疗公司 嵌合因子viii多肽及其用途
CN110054699A (zh) * 2012-07-11 2019-07-26 比奥贝拉蒂治疗公司 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途
CN117720671A (zh) * 2024-01-30 2024-03-19 南通大学 具有自组装性能的重复结构单元重组蛋白ⅠAⅠB-ⅠAⅠBrQTY及应用
US12030925B2 (en) 2018-05-18 2024-07-09 Bioverativ Therapeutics Inc. Methods of treating hemophilia A
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
CN121319224A (zh) * 2025-12-18 2026-01-13 山东艾科达生物科技有限公司 一种检测adamts13活性的蛋白组合及其应用
US12617839B2 (en) 2021-11-05 2026-05-05 Bioverativ Therapeutics Inc. Factor VIII chimeric proteins and uses thereof

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CN106414719B (zh) 2014-06-13 2020-02-14 杰特有限公司 生物反应器中重组von Willebrand因子的改进生产
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KR102788331B1 (ko) * 2017-07-07 2025-03-27 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의해 대기 수술을 받은 중증 폰 빌레브란트 병을 가지고 있는 환자의 치료
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CN121319224A (zh) * 2025-12-18 2026-01-13 山东艾科达生物科技有限公司 一种检测adamts13活性的蛋白组合及其应用

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