CA2728012C - Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life - Google Patents

Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life Download PDF

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Publication number
CA2728012C
CA2728012C CA2728012A CA2728012A CA2728012C CA 2728012 C CA2728012 C CA 2728012C CA 2728012 A CA2728012 A CA 2728012A CA 2728012 A CA2728012 A CA 2728012A CA 2728012 C CA2728012 C CA 2728012C
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CA
Canada
Prior art keywords
modified
fviii
vwf
wild
complex
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2728012A
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English (en)
French (fr)
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CA2728012A1 (en
Inventor
Thomas Weimer
Stefan Schulte
Hubert Metzner
Ulrich Kronthaler
Holger Lind
Wiegand Lang
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CSL Behring GmbH Deutschland
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CSL Behring GmbH Deutschland
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Publication of CA2728012A1 publication Critical patent/CA2728012A1/en
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Publication of CA2728012C publication Critical patent/CA2728012C/en
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2728012A 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life Expired - Fee Related CA2728012C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08011429.1 2008-06-24
EP08011429 2008-06-24
PCT/EP2009/004549 WO2009156137A1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Publications (2)

Publication Number Publication Date
CA2728012A1 CA2728012A1 (en) 2009-12-30
CA2728012C true CA2728012C (en) 2017-10-31

Family

ID=40042814

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728012A Expired - Fee Related CA2728012C (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Country Status (12)

Country Link
US (2) US8575104B2 (https=)
EP (2) EP2291523B1 (https=)
JP (1) JP5832285B2 (https=)
KR (2) KR101648734B1 (https=)
CN (2) CN102076855A (https=)
AU (1) AU2009262476C1 (https=)
CA (1) CA2728012C (https=)
DK (2) DK2865760T3 (https=)
ES (2) ES2531464T3 (https=)
PL (1) PL2291523T3 (https=)
RU (1) RU2528855C2 (https=)
WO (1) WO2009156137A1 (https=)

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Also Published As

Publication number Publication date
AU2009262476C1 (en) 2016-06-02
CN102076855A (zh) 2011-05-25
ES2654336T3 (es) 2018-02-13
KR101507718B1 (ko) 2015-04-10
CA2728012A1 (en) 2009-12-30
DK2291523T3 (en) 2015-03-23
AU2009262476B2 (en) 2014-06-26
KR20110044978A (ko) 2011-05-03
KR101648734B1 (ko) 2016-08-18
EP2291523B1 (en) 2014-12-17
US8575104B2 (en) 2013-11-05
EP2865760B1 (en) 2017-10-11
CN103739712A (zh) 2014-04-23
US20140072561A1 (en) 2014-03-13
PL2291523T3 (pl) 2015-05-29
US9290561B2 (en) 2016-03-22
JP5832285B2 (ja) 2015-12-16
AU2009262476A1 (en) 2009-12-30
CN103739712B (zh) 2016-10-05
KR20140090703A (ko) 2014-07-17
US20110183907A1 (en) 2011-07-28
EP2865760A1 (en) 2015-04-29
RU2528855C2 (ru) 2014-09-20
JP2011525363A (ja) 2011-09-22
DK2865760T3 (en) 2018-01-15
EP2291523A1 (en) 2011-03-09
ES2531464T3 (es) 2015-03-16
WO2009156137A1 (en) 2009-12-30
HK1151068A1 (en) 2012-01-20
RU2011102366A (ru) 2012-07-27

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