CN102067857A - Fungicide combination containing polyoxin - Google Patents
Fungicide combination containing polyoxin Download PDFInfo
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- CN102067857A CN102067857A CN201110043691XA CN201110043691A CN102067857A CN 102067857 A CN102067857 A CN 102067857A CN 201110043691X A CN201110043691X A CN 201110043691XA CN 201110043691 A CN201110043691 A CN 201110043691A CN 102067857 A CN102067857 A CN 102067857A
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Abstract
The invention discloses a fungicide combination containing polyoxin, which is a fungicide combination containing active component A and active component B, the polyoxin is selected as the active component A, the active component B is selected from any of the following fungicides: ethirimol, 2-cyan-3-amino-3-ethyl aminoacrylate, bromothalonil, zineb, chlorothalonil and dithianon, and moreover, the ratio of the active component A to the active component B in part by weight is 32:1 to 1:64. The fungicide combination can prevent and control a variety of crop diseases, has a remarkable synergistic effect, broadens the antifungal spectrum, and has high activity on downy mildew, epidemic diseases, anthracnose, powdery mildew, leaf spot, fusarium head blight, rice blast and other diseases; and moreover, the dosage of pesticide is reduced, the residue of pesticide on crops is decreased, and thereby the environmental pollution is reduced.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of binary that contains polyoxin bactericidal composition that is mixed.
Background technology
Polyoxin (polyoxin), molecular formula: C
17H
25N
5O
14, chemical name: peptide pyrimidine nucleoside.
Structural formula:
Polyoxin broad-spectrum antibiotics class, inhale conduction in having preferably, its mechanism of action is to disturb the chitinous biosynthesis of bacterial cell wall, and germ tube is with after mycelium contacts medicament, expand the part, break, overflow cell inclusion, and can not normal development, cause death, suppress germ in addition and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had poisoning.Main controlling object has wheat powdery mildew, Alternaria alternate, cucumber downy mildew, cucurbits fusarium wilt, genseng black spot, rice seedling blight, alternaria leaf spot of apple, strawberry and worker's grape grey mould, multiple fungal diseases such as forest spike top and pears black spot.
Yet in the real process of agricultural production, preventing and treating the problem that disease is easy to generate most is the drug-fast generation of germ.The different cultivars composition carries out composite, is to prevent and treat the very common method of resistance germ.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals all is an additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery can produce good synergistic effect with polyoxin and the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon after composite, and still unexposed about the composite relevant report of polyoxin and the phonetic phenol of glyoxaline compound second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that contains polyoxin that use cost is low, preventive effect is good.
The bactericidal composition that the present invention proposes contains two kinds of active components of A, B.
Active component A is a polyoxin.
Active component B is selected from following any one bactericide: the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon.
The phonetic phenol of described second (ethirimol), molecular formula are C
11H
19N
3O, chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine.
Described zineb (zineb), molecular formula are C
4H
6N
2S
4Zn, chemical name: zinc ethylenebisdithiocarbamate.
Described 2-cyano-3-amino-3-phenylancryic acetate, molecular formula are C
12H
12N
2O
2, chemical name: 2-cyano group-3-amino-3-aminoacrylic acid ethyl ester.
Described tpn (chlorothalonil), molecular formula are C
8Cl
4N
2, chemical name: daconil M (2,4,5,6-tetrachloro-1,3-benzene dicarbonitrile).
Described bromothalonil (bromothalonil), molecular formula are C
6H
6Br
2N
2, chemical name: 2-bromo-2 bromomethyl glutaronitriles.
Described dithianon (dithianon), molecular formula are C
14H
4N
2O
2S
2, chemical name: 2,3-dinitrile-1,4-anthraquinone dithio.
A kind of bactericidal composition that contains polyoxin, comprise effective active component, auxiliary agent and filler, it is characterized in that: A, B percentage by weight are 32: 1 to 1: 64, active component A is selected from polyoxin, and active component B is the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon.
Described a kind of bactericidal composition that contains polyoxin is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 8: 1 to 1: 32.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and the phonetic phenol of second is 8: 1 to 1: 8.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and zineb is 1: 1 to 1: 16.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and tpn is 1: 1 to 1: 16.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and 2-cyano-3-amino-3-phenylancryic acetate is 2: 1 to 1: 16.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and dithianon is 8: 1 to 1: 8.
The described bactericidal composition that contains polyoxin is characterized in that: the percentage by weight of polyoxin and bromothalonil is 1: 1 to 1: 16.
Usually active weight percentage is 1～90% of a gross weight in the composition, and preferable is 5%～85%.According to different preparation types, the active component content scope is different.Usually, solid pharmaceutical preparation contains 5～85% active substance by weight, preferably is 10～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～30% of a total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from dispersant, wetting agent, binding agent or the defoamer one or more.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, during the ester polyoxyethylene is phonetic one or more.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, the polyvinyl alcohol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by the preparation of common processing method, is about to active substance and after liquid flux or solid carrier mix, and adds in surfactant such as dispersant, stabilizing agent, wetting agent, adhesive, the defoamer etc. one or more again.
Bactericidal composition of the present invention can be processed into acceptable forms on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules.
Comprise following constituent content when composition is made wetting powder: polyoxin 1～35%, active component B 1～80%, dispersant 5～10%, wetting agent 2～10%, filler add to 100%.
Active component polyoxin, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into the wetting powder product of the present composition.
Comprise following constituent content when composition is made water dispersible granules: active component polyoxin 1～35%, active component B 1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler add to 100%.
Active component polyoxin, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, add other auxiliary agents such as binding agent again, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes the water dispersible granules product of the present composition.
The invention has the advantages that: after the compound of (1) two kind of different sterilization mechanism is composite, have notable synergistic and lasting effect; (2) enlarged fungicidal spectrum, diseases such as downy mildew, eqpidemic disease, anthracnose, powdery mildew, leaf spot, head blight, rice blast have all been had greater activity; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Embodiment 1 60% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder
Polyoxin 10%, 2-cyano-3-amino-3-phenylancryic acetate 50%, polyoxyethylene carboxylate 5%, Nekal BX 5%, bentonite add to 100%, and mixture carries out comminution by gas stream, make 60% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder.
Embodiment 2 80% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powders
Polyoxin 15%, 2-cyano-3-amino-3-phenylancryic acetate 65%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, lauryl sodium sulfate 4%, kaolin add to 100%, and mixture carries out comminution by gas stream, make 80% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder.
Embodiment 3 50% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Polyoxin 5%, 2-cyano-3-amino-3-phenylancryic acetate 45%, soapberry powder 6%, alkyl benzene sulfonate calcium salt 5%, ammonium sulfate 1%, bentonite add to 100%, the mixed 50% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules that gets.
Embodiment 4 30% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Polyoxin 5%, 2-cyano-3-amino-3-phenylancryic acetate 25%, wetting and penetrating agent F 4%, lignosulfonates 5%, urea 0.6%, bentonite add to 100%, the mixed 30% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules that gets.
Embodiment 9 60% polyoxin bromothalonil wetting powders
Polyoxin 10%, bromothalonil 50%, lignosulfonates 6%, wetting and penetrating agent F 5%, kaolin add to 100%, and mixture carries out comminution by gas stream, make 60% polyoxin bromothalonil wetting powder.
Embodiment 10 75% polyoxin bromothalonil wetting powders
Polyoxin 10%, bromothalonil 65%, alkyl benzene sulfonate calcium salt 5%, spaonin powder 4%, kaolin add to 100%, and mixture carries out comminution by gas stream, make 75% polyoxin bromothalonil wetting powder.
Embodiment 11 40% polyoxin bromothalonil water dispersible granules
Polyoxin 10%, bromothalonil 30%, alkylphenol-polyethenoxy are phonetic 7%, lauryl sodium sulfate 5%, aluminium chloride 0.5%, starch 15%, diatomite add to 100%, mixed 40% polyoxin bromothalonil water dispersible granules.
Embodiment 12 75% polyoxin bromothalonil water dispersible granules
Polyoxin 5%, bromothalonil 70%, polyoxyethylene carboxylate 6%, silkworm excrement 5%, urea 0.4%, bentonite add to 100%, the mixed 75% polyoxin bromothalonil water dispersible granules that gets.
Embodiment 17 60% polyoxin Zineb wettable powders
Polyoxin 10%, zineb 50%, aryl phenol polyoxyethylene succinate sulfonate 8%, wetting and penetrating agent F 5%, attapulgite add to 100%, and mixture carries out comminution by gas stream, make 60% polyoxin Zineb wettable powder.
Embodiment 18 80% polyoxin Zineb wettable powders
Polyoxin 5%, zineb 75%, lignosulfonates 7%, spaonin powder 5%, precipitated calcium carbonate add to 100%, and mixture carries out comminution by gas stream, make 80% polyoxin Zineb wettable powder.
Embodiment 19 50% polyoxin water dispersion granules agent of dithane
Polyoxin 3%, zineb 47%, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, the mixed 50% polyoxin water dispersion granules agent of dithane that gets.
Embodiment 20 65% polyoxin water dispersion granules agent of dithane
Polyoxin 1%, zineb 64%, lignosulfonates 3%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, the mixed 65% polyoxin water dispersion granules agent of dithane that gets.
Embodiment 25 45% polyoxin tpn wetting powders
Polyoxin 2%, tpn 43%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 45% polyoxin tpn wetting powder.
Embodiment 26 80% polyoxin tpn wetting powders
Polyoxin 6%, tpn 74%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, soapberry powder 6%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 80% polyoxin tpn wetting powder.
Embodiment 27 36% polyoxin chlorothalonil water dispersible granules
Polyoxin 6%, tpn 30%, lignosulfonates 6%, wetting and penetrating agent F 5%, ammonium sulfate 1.2%, bentonite add to 100%, the mixed 36% polyoxin chlorothalonil water dispersible granule that gets.
Embodiment 28 50% polyoxin chlorothalonil water dispersible granules
Polyoxin 2%, tpn 48%, alkylnaphthalene sulfonate 6%, spaonin powder 4%, ammonium sulfate 1%, bentonite add to 100%, the mixed 50% polyoxin chlorothalonil water dispersible granule that gets.
The phonetic phenol wetting powder of embodiment 33 60% polyoxin second
Polyoxin 20%, the phonetic phenol 40% of second, aryl phenol polyoxyethylene succinate sulfonate 6%, wetting and penetrating agent F 5%, attapulgite add to 100%, and mixture carries out comminution by gas stream, make the phonetic phenol wetting powder of 60% polyoxin second.
The phonetic phenol wetting powder of embodiment 34 30% polyoxin second
Polyoxin 10%, the phonetic phenol 20% of second, lignosulfonates 4%, spaonin powder 5%, kaolin add to 100%, and mixture carries out comminution by gas stream, make the phonetic phenol wetting powder of 30% polyoxin second.
Embodiment 35 50% polyoxin ethirimol water dispersible granules
Polyoxin 10%, the phonetic phenol 40% of second, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, the mixed 50% polyoxin ethirimol water dispersible granules that gets.
Embodiment 36 20% polyoxin ethirimol water dispersible granules
Polyoxin 10%, the phonetic phenol 10% of second, lignosulfonates 4%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, the mixed 20% polyoxin ethirimol water dispersible granules that gets.
Embodiment 41 45% polyoxin dithianon wetting powders
Polyoxin 5%, dithianon 40%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out comminution by gas stream, make 45% polyoxin dithianon wetting powder.
Embodiment 42 30% polyoxin dithianon wetting powders
Polyoxin 5%, dithianon 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, soapberry powder 6%, kaolin add to 100%, and mixture carries out comminution by gas stream, make 30% polyoxin dithianon wetting powder.
Embodiment 43 30% polyoxin dithianon water-dispersion granules
Polyoxin 6%, dithianon 24%, lignosulfonates 6%, spaonin powder 5%, ammonium sulfate 1%, bentonite add to 100%, the mixed 30% polyoxin dithianon water-dispersion granule that gets.
Embodiment 44 10% polyoxin dithianon water-dispersion granules
Polyoxin 8%, dithianon 2%, alkylnaphthalene sulfonate 6%, wetting and penetrating agent F4%, starch 2%, bentonite add to 100%, the mixed 10% polyoxin dithianon water-dispersion granule that gets.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
The composite Toxicity Determination of polyoxin and active component B (B be selected from the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, the dithianon a kind of) to target.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament the target germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component polyoxin and B (the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon) shared ratio in combination;
A is a polyoxin;
B is a kind of in the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, the dithianon.
Implementation of an application example two:
The phonetic phenol of polyoxin and second is composite to the powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of the phonetic phenol of second and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 polyoxin, the phonetic phenol of second and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 1, polyoxin, the phonetic phenol of second are to the EC of powdery mildew of cucumber
50Be respectively 1.15mg/L and 1.32mg/L.Polyoxin compares at 32: 1 to 1: 64 o'clock with the phonetic phenol of second, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and 2-cyano-3-amino-3-phenylancryic acetate were mixed in the scope at 32: 1 to 1: 64 all shows synergistic effect, especially when the two proportioning during at 8: 1 to 1: 8, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and the phonetic phenol weight ratio of second are 1: 12 wherein, synergistic effect is the most obvious.
Implementation of an application example three
Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are composite to the wheat scab Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of 2-cyano-3-amino-3-phenylancryic acetate and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 polyoxin, 2-cyano-3-amino-3-phenylancryic acetate and composite toxicity test analysis of results table thereof to wheat scab
As shown in Table 2, polyoxin, 2-cyano-3-amino-3-phenylancryic acetate are to the EC of wheat scab
50Be respectively 1.36mg/L and 1.92mg/L.Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate proportioning were at 32: 1 to 1: 64 o'clock, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and 2-cyano-3-amino-3-phenylancryic acetate were mixed in the scope at 32: 1 to 1: 64 all shows synergistic effect, especially when the two proportioning during at 8: 1 to 1: 8, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and 2-cyano-3-amino-3-phenylancryic acetate weight ratio are 1: 2 wherein, synergistic effect is the most obvious.
Implementation of an application example four
Polyoxin and bromothalonil are composite to the apple mildew Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of bromothalonil and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 polyoxin, bromothalonil and composite toxicity test analysis of results table thereof to apple mildew
As shown in Table 3, polyoxin, bromothalonil are to the EC of apple mildew
50Be respectively 1.25mg/L and 2.36mg/L.Polyoxin and bromothalonil proportioning were at 32: 1 to 1: 64 o'clock, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and bromothalonil were mixed in the scope at 32: 1 to 1: 64 all shows synergistic effect, especially when the two proportioning during at 2: 1 to 1: 16, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and bromothalonil weight ratio are 1: 4 wherein, synergistic effect is the most obvious.
Implementation of an application example five
Polyoxin and zineb are composite to the tomato blight Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of zineb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 polyoxin, zineb and composite toxicity test analysis of results table thereof to leaf spot of peanut
As shown in Table 4, polyoxin, zineb are to the EC of tomato blight
50Be respectively 1.16mg/L and 23.28mg/L.Polyoxin and zineb proportioning were at 32: 1 to 1: 128 o'clock, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and zineb were mixed in the scope at 32: 1 to 1: 128 all shows synergistic effect, especially when the two proportioning during at 1: 1 to 1: 16, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and zineb weight ratio are 1: 8 wherein, synergistic effect is the most obvious.
Implementation of an application example six:
Polyoxin and chlorothalonil compound are to the downy mildew of garpe Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of tpn and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 5 polyoxin, tpn and composite toxicity test analysis of results table thereof to downy mildew of garpe
As shown in Table 5, polyoxin, tpn are to the EC of downy mildew of garpe
50Be respectively 1.28mg/L and 29.64mg/L.Polyoxin compares at 32: 1 to 1: 128 o'clock with tpn, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and tpn were mixed in the scope at 32: 1 to 1: 128 all shows synergistic effect, especially when the two proportioning during at 1: 1 to 1: 16, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and tpn weight ratio are 1: 8 wherein, synergistic effect is the most obvious.
Implementation of an application example seven:
Polyoxin and dithianon are composite to the capsicum epidemic disease Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of dithianon and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 6 polyoxin, tpn and composite toxicity test analysis of results table thereof to capsicum epidemic disease
As shown in Table 6, polyoxin, dithianon are to the EC of capsicum epidemic disease
50Be respectively 1.13mg/L and 1.26mg/L.Polyoxin compares at 32: 1 to 1: 128 o'clock with dithianon, synergy ratio SR is all greater than 1.5, illustrating that polyoxin and dithianon were mixed in the scope at 32: 1 to 1: 128 all shows synergistic effect, especially when the two proportioning during at 8: 1 to 1: 8, synergistic effect is more obviously outstanding, synergy ratio SR maximum when polyoxin and dithianon weight ratio are 1: 1 wherein, synergistic effect is the most obvious.
Application Example eight
Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate and the composite wheat scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Yongshou County, Xianyang, Shanxi province city, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 25% 2-cyano-3-amino-3-phenylancryic acetate suspending agent (commercial).
Investigation wheat scab disease index before the medicine, in the their early stage dispenser, dispenser for the second time after 7 days, dispenser is 2 times altogether, for the third time 7 days, 14 days investigation disease indexs and calculate preventive effect after the dispenser.Experimental result is as follows:
Table 6 polyoxin, 2-cyano-3-amino-3-phenylancryic acetate and the composite wheat scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 6, can effectively prevent and treat wheat scab after polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example nine polyoxins and bromothalonil and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment is in suburb, Zibo City, Shandong Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 25% bromothalonil wetting powder (commercial).
The investigation cucumber downy mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 7 polyoxin, bromothalonil and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 7, can effectively prevent and treat cucumber downy mildew after polyoxin and bromothalonil are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example ten polyoxins and zineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Hu County, Xian City, Shanxi Province, and test medicine is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 80% Zineb wettable powder (commercial).
The investigation downy mildew of garpe state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 8 polyoxin, zineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, can effectively prevent and treat downy mildew of garpe after polyoxin and zineb are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example 11 polyoxins and tpn and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 75% tpn wetting powder (commercial).
The preceding investigation of medicine rice blast disease index, in the their early stage dispenser, dispenser for the second time after 7 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 14 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
Table 9 polyoxin, tpn and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 9, can effectively prevent and treat the preventive effect that the rice blast control efficiency all is better than single agent behind polyoxin and the chlorothalonil compound.In the test scope of medication, the target crop is had no adverse effects.
Application Example 12 polyoxins and the phonetic phenol of second and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Hua County, Henan Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), the phonetic phenol suspending agent of 25% second (commercial).
The preceding investigation of medicine powdery mildew of cucumber disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 14 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
Table 10 polyoxin, the phonetic phenol of second and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 10, can effectively prevent and treat powdery mildew of cucumber after the phonetic phenol of polyoxin and second is composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Application Example 13 polyoxins and dithianon and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
This experimental establishment is in the Quzhou County, Hebei province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 22.7% dithianon suspending agent (commercial).
The preceding investigation of medicine capsicum epidemic disease disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 14 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
Table 10 polyoxin, dithianon and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
As can be seen from Table 10, can effectively prevent and treat capsicum epidemic disease after polyoxin and dithianon are composite, control efficiency all is better than the preventive effect of single agent.In the test scope of medication, the target crop is had no adverse effects.
Claims (10)
1. bactericidal composition that contains polyoxin, comprise effective active component, auxiliary agent and filler, it is characterized in that: A, B percentage by weight are 32: 1 to 1: 64, described A is selected from polyoxin, and B is selected from the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon.
2. the bactericidal composition that contains polyoxin according to claim 1 is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 8: 1 to 1: 32.
3. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and the phonetic phenol of second is 8: 1 to 1: 8.
4. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and zineb is 1: 1 to 1: 16.
5. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and tpn is 1: 1 to 1: 16.
6. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and 2-cyano-3-amino-3-phenylancryic acetate is .2: 1 to 1: 16.
7. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and dithianon is 8: 1 to 1: 8.
8. according to the described bactericidal composition that contains polyoxin of claim 2, it is characterized in that: the percentage by weight of polyoxin and bromothalonil is 2: 1 to 1: 16.
9. according to the bactericidal composition of the described polyoxin that contains of claim 1, it is characterized in that: wherein the effective active composition accounts for 5%～80% of gross weight.
10. according to the bactericidal composition of the described polyoxin that contains of claim 1, be used to prevent and treat crop downy mildew, eqpidemic disease, anthracnose, powdery mildew, leaf spot, head blight, rice blast.
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| CN201110043691XA CN102067857A (en) | 2011-02-23 | 2011-02-23 | Fungicide combination containing polyoxin |
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| CN201410007495.0A Division CN103734158A (en) | 2011-02-23 | 2011-02-23 | Polyoxins-containing bactericidal composition |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308817A (en) * | 2011-07-27 | 2012-01-11 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition |
| CN102349523A (en) * | 2011-10-17 | 2012-02-15 | 海利尔药业集团股份有限公司 | High-efficient sterilization composition containing bupirimate |
| CN102687722A (en) * | 2011-03-22 | 2012-09-26 | 联保作物科技有限公司 | Bactericidal composition for preventing and curing powdery mildew and preparation thereof |
| CN103975943A (en) * | 2013-05-07 | 2014-08-13 | 江苏辉丰农化股份有限公司 | Sterilization composition with synergic effect |
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
| CN103651579B (en) * | 2012-09-13 | 2016-01-13 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing dimoxystrobin and antibiotics |
| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
| CN107347899A (en) * | 2017-03-27 | 2017-11-17 | 兴农药业（中国）有限公司 | A kind of compound pesticide composition containing polyoxin and Bravo |
| CN110583669A (en) * | 2019-10-28 | 2019-12-20 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN111066806A (en) * | 2020-01-16 | 2020-04-28 | 陕西麦可罗生物科技有限公司 | Pesticide composition containing polyoxin B and iodopropynyl compound and application thereof |
| CN113907085A (en) * | 2021-11-16 | 2022-01-11 | 陕西麦可罗生物科技有限公司 | Bactericidal composition containing polyoxin and bromothalonil and application thereof |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102687722A (en) * | 2011-03-22 | 2012-09-26 | 联保作物科技有限公司 | Bactericidal composition for preventing and curing powdery mildew and preparation thereof |
| CN102687722B (en) * | 2011-03-22 | 2014-01-15 | 联保作物科技有限公司 | Bactericidal composition for preventing and curing powdery mildew and preparation thereof |
| CN102308817A (en) * | 2011-07-27 | 2012-01-11 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition |
| CN102349523A (en) * | 2011-10-17 | 2012-02-15 | 海利尔药业集团股份有限公司 | High-efficient sterilization composition containing bupirimate |
| CN103651579B (en) * | 2012-09-13 | 2016-01-13 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing dimoxystrobin and antibiotics |
| CN103975943B (en) * | 2013-05-07 | 2015-08-26 | 江苏辉丰农化股份有限公司 | There is the bactericidal composition of synergistic effect |
| CN103975943A (en) * | 2013-05-07 | 2014-08-13 | 江苏辉丰农化股份有限公司 | Sterilization composition with synergic effect |
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
| CN104488870B (en) * | 2014-12-24 | 2016-08-17 | 陕西汤普森生物科技有限公司 | A kind of composition pesticide containing bromothalonil |
| CN107347899A (en) * | 2017-03-27 | 2017-11-17 | 兴农药业（中国）有限公司 | A kind of compound pesticide composition containing polyoxin and Bravo |
| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
| CN110583669A (en) * | 2019-10-28 | 2019-12-20 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN110583669B (en) * | 2019-10-28 | 2022-03-15 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN111066806A (en) * | 2020-01-16 | 2020-04-28 | 陕西麦可罗生物科技有限公司 | Pesticide composition containing polyoxin B and iodopropynyl compound and application thereof |
| CN113907085A (en) * | 2021-11-16 | 2022-01-11 | 陕西麦可罗生物科技有限公司 | Bactericidal composition containing polyoxin and bromothalonil and application thereof |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Applicant after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shaanxi Meibang Pesticide Co., Ltd. |
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Application publication date: 20110525 |