CN102687722B - Bactericidal composition for preventing and curing powdery mildew and preparation thereof - Google Patents
Bactericidal composition for preventing and curing powdery mildew and preparation thereof Download PDFInfo
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- CN102687722B CN102687722B CN201110068659.7A CN201110068659A CN102687722B CN 102687722 B CN102687722 B CN 102687722B CN 201110068659 A CN201110068659 A CN 201110068659A CN 102687722 B CN102687722 B CN 102687722B
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- powdery mildew
- bactericidal composition
- polyoxin
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 67
- 241000221785 Erysiphales Species 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title abstract description 17
- 229930182764 Polyoxin Natural products 0.000 claims abstract description 34
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 claims abstract description 34
- 239000003899 bactericide agent Substances 0.000 claims abstract description 23
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the field of pesticide preparations and discloses a bactericidal composition for preventing and curing powdery mildew. The bactericidal composition provided by the invention is composed of ethirimol and polyoxin, wherein the weight ratio of ethirimol to polyoxin is 1-99:99-1. The invention also discloses a bactericide for preventing and curing powdery mildew. An active component of the bactericide is composed of the bactericidal composition. The bactericidal composition accounts for 1-99% of the weight of the bactericide. by the adoption of the bactericidal composition and its preparation, their effects for preventing powdery mildew are remarkably raised; they have obvious synergistic effects; the amount of effective components is minimized; powdery mildew resistance is delayed; and environmental pollution is reduced. The invention can be widely applied in the agricultural field.
Description
Technical field
The present invention relates to pesticidal preparations field, relate to specifically a kind of bactericidal composition and preparation thereof of preventing and treating powdery mildew.
Background technology
Powdery mildew is the fungus-caused plant disease in Erysiphaceae (Erysiphacesae), mostly be ectoparasitism, whole or the large portion of mycelium is exposed to leaf, stem, the tender tip, bud, flower and the fruit real surface of host plant, and produce the macroscopic white powder being formed by mycelium, conidiophore and conidium in a large number, be therefore called powdery mildew.
Powdery mildew is widely distributed in China, particularly general to the harm of dicotyledon.After powdery mildew occurs, host's position growth of being injured is suppressed, moves back gradually green flavescence, occurs that withered spot is dried-up to last full leaf, if many blades are injured simultaneously, also can make plant early withered., in the mould layer of white powder shape consisting of, often there is the granular cleistothecium of many scattered black, and survive the winter with this mycelia and conidium in the disease later stage, the inferior spring carries out just infecting with ascospore.The conidium of Powdery Mildew all can sprout at 10-30 ℃, not high to humidity requirement, within 10 days, can complete and once infect circulation under normal circumstances, and a season of growth of crops can be infected repeatedly, once generation will very fast its spread in china.Powdery mildew makes the crop products such as China's wheat, cucumber, grape be subjected to very big loss, has had a strong impact on the development of China's agricultural.Therefore, how effectively to prevent that the generation of powdery mildew and propagation from just becoming the major issue in agriculture field.
Current, the powdery mildew medicament of preventing and treating of domestic registration has 26 kinds such as triadimefon, kresoxim-methyl, Flusilazole, Difenoconazole, nitrile bacterium azoles, and the domestic powdery mildew medicament of preventing and treating has roughly experienced three phases:
It is representative that first stage be take the inorganic sulfurs such as sulphur, lime sulfur, thiophanate methyl, mancozeb and other wide-spectrum bactericide; such dosing is large; preventive effect is only 60% left and right; to powdery mildew almost without result for the treatment of; be mainly used in premorbid protection; sulphur preparation is responsive to many vegetable melon and fruits simultaneously, and most vegetable melon and fruits can not be used.
Second stage is to take the triazole germicide series that triazolone (triadimefon), nitrile bacterium azoles, alkene azoles alcohol, Difenoconazole, Flusilazole etc. are representative, such medicament improves a lot to the specific activity first generation bactericide of powdery mildew, but single to germ action site, easy and Powdery Mildew produces cross resistance, and pharmacy control efficacy is substantially at 70-80%, and effect is general.Meanwhile, this compounds is irritant to plant, and consumption will suppress plant growth slightly greatly, reduces output.
Phase III is to take the noval chemical compound kind that the phonetic phenol of second, kresoxim-methyl is representative, and such pharmacy effect mechanism is unique, and action site is more, to powdery mildew specially higher, the effect of the property controlled can reach 90% left and right.But, still can not prevent to greatest extent generation and the propagation of powdery mildew.
Chinese patent CN101755842A discloses " bactericidal composition that contains kresoxim-methyl ", and composition has comprised the phonetic phenol of second and kresoxim-methyl described in this patent, in order to prevent and treat powdery mildew.But, because kresoxim-methyl is long-term, use continuously, Powdery Mildew is produced to obvious pesticide resistance, therefore the phonetic phenol of second and kresoxim-methyl composition mainly rely on the phonetic phenol of second to realize to the preventive effect of powdery mildew, successful reduces.
Summary of the invention
In view of this, the object of the invention is to provide a kind of bactericidal composition and preparation thereof of preventing and treating powdery mildew, makes the present invention can improve the preventive effect to powdery mildew.
For realizing object of the present invention, the present invention adopts following technical scheme:
Prevent and treat a bactericidal composition for powdery mildew, by the phonetic phenol of second and polyoxin, formed.
The phonetic phenol of second, chemical name is 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine, belongs to heterocyclic nitrogen-group fungicide, the ICI company of Shi You Britain research and development are the earliest released.The mechanism of action of the phonetic phenol of second is the inhibitor as adenosine deaminase, and plant is played to protection and therapeutic action.The phonetic phenol of second is more to the treatment site of powdery mildew, has good interior suction conductive performance, and while making Dressing, active ingredient can be diffused into each position of plant with the conduction of plant through root absorption, thereby plays the object of the whole strain crop of protection.If the phonetic phenol of second is sprayed onto to leaf portion, active ingredient can, by blade Assimilation and conductivity to young leaves, prevent that disease from spreading to young leaves.The phonetic phenol of second waits homoiothermy animal toxicity low to people and animals, and safer to birds, fish, consumption is few, drug effect is high, particularly good to mycelium and conidial killing effect.In addition, the phonetic phenol of second is easily degraded in environment, and some promotes the effect of plant growth in addition.
Polyoxin has another name called Polyoxin, multi-effect mycin, it is the biological bactericide of being produced by the research and development of Japanese RIKEN, Japanese Kaken Pharmaceufical Co., Ltd., there is interior suction conduction, can prevent and treat the multiple fungal diseases such as powdery mildew, gray mold, anthracnose, belong to peptide pyridimine nucleosides broad spectrum activity antibiotic pesticide.The structure of polyoxin exactly likes the substrate uridine 5'-diphosphate acetylglucosamine of chitin synthetase, it is nearly thousand times of uridine 5'-diphosphate acetylglucosamine to the affinity of chitin synthetase, therefore optionally the composition of Antifungi cell wall is chitinous synthetic for polyoxin, can make germ tube and mycelium part expand, break simultaneously, cell inclusion releases, and causes death.In addition, polyoxin can also suppress the generation of spore and the expansion of scab.Polyoxin is to animal avirulence, not only without poisoning but also there is stimulation growth, high, free from environmental pollution to people, animal, crop safety to plant.
The weight ratio of the phonetic phenol of second of the present invention and polyoxin is 1-99: 99-1, is preferably 11.8-88.2: 88.2-11.8, more preferably 16.7-83.3: 83.3-16.7, more preferably 76.9-83.3: 23.1-16.7.
Different fungicidal activity components are mixed rear each active component due to the difference of composition, structure, physicochemical property, make the synergy between each active component be typically expressed as synergistic effect, summation action or antagonism.So-called synergistic effect is exactly the mutual synergism between different material, and the effect of its generation is greater than the sum total of each composition effect; And the effect that summation action is exactly its generation equals the sum total of each composition effect; Antagonism refers to that when two kinds of materials act on living organism, a kind of material disturbs the effect of another kind of material, or the effect of interfering with an opponent each other, the phenomenon that general effect is declined.
The present invention has carried out controlling powdery mildew test to each composition single dose in bactericidal composition and bactericidal composition respectively, result shows, the preventive effect of bactericidal composition of the present invention is than the high 4-7% of preventive effect of each composition single dose in composition, show that in bactericidal composition of the present invention, each composition is without cross tolerance, control efficiency has synergistic effect.
The present invention also provides a kind of bactericide of preventing and treating powdery mildew, and its active component is comprised of bactericidal composition of the present invention, and the percentage by weight that described bactericidal composition accounts for described bactericide is 1-99%, is preferably 20-80%.
Bactericide of the present invention can be made wetting powder, missible oil, suspending agent, aqua, microcapsule suspending agent or water dispersible granules by bactericidal composition of the present invention and conventional auxiliary material as required.Experiment shows, bactericide of the present invention can be prevented and treated powdery mildew effectively.
From above technical scheme, the powdery mildew preventive effect of bactericidal composition of the present invention and preparation thereof significantly improves, and has notable synergistic effect, reduce the consumption of active ingredient, delay the drug-fast generation of Powdery Mildew, and reduce the pollution to environment, can be widely used in agriculture field.
Embodiment
The embodiment of the invention discloses a kind of bactericidal composition and preparation thereof of preventing and treating powdery mildew.Those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Product of the present invention is described by preferred embodiment, and related personnel obviously can change product as herein described or suitably change and combination within not departing from content of the present invention, spirit and scope, realizes and apply the technology of the present invention.
According to the present invention, described a kind of bactericidal composition of preventing and treating powdery mildew, is comprised of the phonetic phenol of second and polyoxin.The weight ratio of the phonetic phenol of second of the present invention and polyoxin is 1-99: 99-1, is preferably 11.8-88.2: 88.2-11.8, more preferably 16.7-83.3: 83.3-16.7, more preferably 76.9-83.3: 23.1-16.7.
The present invention has carried out controlling powdery mildew test to each composition single dose in bactericidal composition and bactericidal composition respectively, and in bactericidal composition, each composition consumption is less than each composition single dose consumption, result shows, bactericidal composition of the present invention, is about to the phonetic phenol of second and with certain proportion, mixes use with polyoxin and have notable synergistic effect.
The former medicine of agricultural chemicals is that active component generally can not directly be used, and must process and be mixed with various types of preparations, could use.Therefore, the present invention also provides a kind of bactericide of preventing and treating powdery mildew, and active component is comprised of bactericidal composition of the present invention, and the percentage by weight that described bactericidal composition accounts for described bactericide is 1-99%, is preferably 20-80%.
The form of preparation claims formulation, and what agricultural chemicals use was at present more is that pulvis, aqua, wetting powder, missible oil, suspending agent, microcapsule suspending agent, water dispersible granules etc. more than ten are planted formulation.Miticide of the present invention comprises wetting powder, missible oil, suspending agent, microcapsule suspending agent and water dispersible granules.
Wherein, wetting powder of the present invention comprises bactericidal composition, wetting agent, dispersant, carrier and inserts.Missible oil of the present invention comprises bactericidal composition, benzene or dimethylbenzene and surfactant.Suspending agent of the present invention comprises bactericidal composition, wetting dispersing agent, viscosity modifier, antifreezing agent and defoamer.Microcapsule suspending agent of the present invention comprises bactericidal composition, solvent, curing agent and viscosity modifier.Aqua of the present invention and water dispersible granules comprise bactericidal composition, wetting agent, disintegrant, dispersant, adhesive, interleaving agent and carrier.
Bactericide of the present invention can also be made the multiple formulations such as conventional granule except above-mentioned formulation, fumicants, aerosol, ultra low volume preparation, fumigant as required, to be applied to agricultural production.
Above various preparations auxiliary agent, surfactant, carrier and other auxiliary materials used of preparation is and well known to a person skilled in the art, if wetting agent is sulfonated oil, Nekal BX, soybean lecithin, thio-alcohol, hydrazides class, mercaptan acetals and polyethylene glycol oxide alkanisation ether etc.; Dispersant is sodium phosphate trimer, sodium pyrophosphate, lauryl sodium sulfate, cellulose derivatives, polyacrylamide, fatty acid polyethylene glycol ester and fatty alcohol oxirane etc.; Disintegrant is dried starch, sodium carboxymethyl starch, low substituted hydroxy-propyl methylcellulose, crospolyvinylpyrrolidone etc.; Adhesive is polyurethane, polystyrene, polyacrylate, vinyl acetate resin etc.; Solvent can be various aromatic hydrocarbons, aliphatic hydrocarbon, ketone etc.
Experiment shows, bactericide of the present invention can be prevented and treated powdery mildew effectively, as powdery mildew of cucumber etc.
In order further to understand the present invention, below in conjunction with embodiment, a kind of bactericidal composition and preparation thereof of preventing and treating powdery mildew provided by the invention is elaborated.
Embodiment 1: the efficiency test of bactericidal composition of the present invention to powdery mildew of cucumber
Test in Zhengzhou, henan one peasant household vegetable garden and carry out, bactericidal composition is mixed with the phonetic phenol of second and polyoxin, and described bactericidal composition and each composition single dose are all dissolved rear dispenser with clear water.Wherein, every processing repeats for 4 times, and community area is 30m
2，Gong28Ge community, in the medication of powdery mildew initial stage of origination, presses 675kg/hm
2evenly spray, within after dispenser 7 days for the first time, comply with identical consumption heavy dressing once, investigation state of an illness radix before dispenser, execute for the last time 10 days " Invest, Then Investigate " preventive effects, every community is fixed 4 points at random, whole blades of every some investigation 2 strains, and every leaf accounts for the percentage classification record of leaf area by scab, calculate disease index, calculate control efficiency, severity Scaling is in Table 1, and test is processed and be the results are shown in Table 2.
Preventive effect is calculated according to formula below:
Disease index=100 * ∑ (the sick numbers of sheets at different levels * typical values at different levels) ÷ (investigating the total number of sheets * 9)
Control efficiency=[(check plot disease index growth rate-treatment region disease index growth rate) ÷ check plot disease index growth rate] * 100%
Table 1 severity Scaling
| 0 grade | Without scab |
| 1 grade | Lesion area accounts for whole leaf area below 5% |
| 3 grades | Lesion area accounts for whole leaf area 6%～10% |
| 5 grades | Lesion area accounts for whole leaf area 11%～20% |
| 7 grades | Lesion area accounts for whole leaf area 21%～40% |
| 9 grades | Lesion area accounts for whole leaf area more than 40% |
The preventive effect of table 2 bactericidal composition of the present invention to powdery mildew of cucumber
| Each processes dispenser dosage (g/ hectare) | Disease index before dispenser | Disease index after dispenser | Preventive effect (%) |
| The phonetic phenol of second (300) | 6.23 | 7.45 | 92.25 |
| Polyoxin (60) | 5.37 | 6.62 | 93.13 |
| The phonetic phenol of second (200)+polyoxin (40) | 6.05 | 6.55 | 96.83 |
| The phonetic phenol of second (200)+polyoxin (60) | 4.43 | 4.55 | 99.24 |
| The phonetic phenol of second (255)+polyoxin (34) | 5.16 | 5.41 | 98.41 |
| The phonetic phenol of second (250)+polyoxin (50) | 5.71 | 5.72 | 99.94 |
| Clear water | 4.94 | 20.69 | 0 |
As seen from the results in Table 2, the phonetic phenol of active ingredient second and polyoxin are mixed, each composition consumption is compared minimizing with each single dose consumption, the total consumption of composition is less than or equal to each single dose consumption, but the 4-7% of preventive effect when preventive effect is used higher than each single dose after dispenser, the powdery mildew preventive effect that shows bactericidal composition of the present invention significantly improves, and has notable synergistic effect.
Embodiment: the phonetic phenol polyoxin of 2:80% second wetting powder
The phonetic phenol of 66.7% second, 13.3% polyoxin, 5% alkylphenol polyoxyethylene are fully mixed in proportion with 7% fatty alcohol oxirane, and diatomite is mended to 100%, makes wetting powder after ultra-fine pulverizer disintegrating.
The phonetic phenol polyoxin of embodiment 3:65% second missible oil
The phonetic phenol of 50% second, 15% polyoxin, 10% benzene and 15% dimethylbenzene and 10% dodecyl sodium sulfate fully mix in proportion, through mix and blend processing, obtain cream preparation successively.
The phonetic phenol polyoxin of embodiment 4:50% second suspending agent
The phonetic phenol of 41.7% second, 8.3% polyoxin, 2% xylonic acid sodium sulfonate, 3% alumina silicate, 5% ethylene glycol, 1% isopropyl alcohol, water benefit to 100% common process makes suspending agent.
The phonetic phenol polyoxin of embodiment 5:35% second microcapsule suspending agent
The phonetic phenol of 5.8% second, 29.2% polyoxin, 13% benzene, 30% curing agent is directly scattered in 11% polyvinyl alcohol after mixing by proportioning, then adds other solvent to mend to 100%, makes microcapsule suspending agent after slow reaction.
The phonetic phenol polyoxin of embodiment 6:20% second water dispersible granules
The phonetic phenol of 4.6% second, 15.4% polyoxin, 10% sulfonated oil, 19% sodium carboxymethyl starch, 26% sodium phosphate trimer and polystyrene, 16% calcium carbonate, 9% carrier mix, after pulverizing, make wetting powder, add afterwards a certain amount of water mixing extruder grain, after drying screening, make water dispersible granules.
The phonetic phenol polyoxin aqueous solution of embodiment 7:90% second
The phonetic phenol of 75% second, 15% polyoxin, 2%Silwet618,2% ammonium sulfate, 3% polyvinyl alcohol and 2% defoamer SAG622 fully mix, and water benefit to 100% common process makes aqua.
Embodiment 8: the field trial of bactericide of the present invention
The bactericide of embodiment 2 to 7 is carried out to efficiency test according to the method for embodiment 1 to powdery mildew of cucumber, wheat powdery mildew, grape powdery mildew, and concrete preventive effect is in Table 3.
The preventive effect of table 3 bactericide of the present invention to powdery mildew
As shown in Table 3, bactericide of the present invention and described bactericidal composition have the control efficiency of same degree, can be applied to agricultural production.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.
Claims (4)
1. a bactericidal composition of preventing and treating powdery mildew, is characterized in that, the phonetic phenol of second and polyoxin, consists of, and the weight ratio of the phonetic phenol of described second and polyoxin is 5:1,10:3,15:2.
2. a bactericide of preventing and treating powdery mildew, is characterized in that, active component is comprised of bactericidal composition described in claim 1, and the percentage by weight that described bactericidal composition accounts for described bactericide is 1-99%.
3. bactericide according to claim 2, is characterized in that, the percentage by weight that described bactericidal composition accounts for described bactericide is 20-80%.
4. bactericide according to claim 2, is characterized in that, by described bactericidal composition and conventional adjuvant, makes wetting powder, missible oil, suspending agent, aqua, microcapsule suspending agent or water dispersible granules.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2014167A1 (en) * | 2007-07-13 | 2009-01-14 | Bayer CropScience AG | Active compound combinations |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN102067857A (en) * | 2011-02-23 | 2011-05-25 | 陕西美邦农药有限公司 | Fungicide combination containing polyoxin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2014167A1 (en) * | 2007-07-13 | 2009-01-14 | Bayer CropScience AG | Active compound combinations |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN102067857A (en) * | 2011-02-23 | 2011-05-25 | 陕西美邦农药有限公司 | Fungicide combination containing polyoxin |
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