CN102150676A - Synergic sterilization composition containing captan - Google Patents
Synergic sterilization composition containing captan Download PDFInfo
- Publication number
- CN102150676A CN102150676A CN2010105854753A CN201010585475A CN102150676A CN 102150676 A CN102150676 A CN 102150676A CN 2010105854753 A CN2010105854753 A CN 2010105854753A CN 201010585475 A CN201010585475 A CN 201010585475A CN 102150676 A CN102150676 A CN 102150676A
- Authority
- CN
- China
- Prior art keywords
- captan
- prochloraz
- methyl
- thiophanate
- manganese chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LDVVMCZRFWMZSG-OLQVQODUSA-N (3ar,7as)-2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione Chemical compound C1C=CC[C@H]2C(=O)N(SC(Cl)(Cl)Cl)C(=O)[C@H]21 LDVVMCZRFWMZSG-OLQVQODUSA-N 0.000 title claims abstract description 198
- 239000005745 Captan Substances 0.000 title claims abstract description 198
- 229940117949 captan Drugs 0.000 title claims abstract description 198
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 7
- 230000002195 synergetic effect Effects 0.000 title claims description 33
- 239000005820 Prochloraz Substances 0.000 claims abstract description 74
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical compound C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 claims abstract description 74
- OXOKTPUZOHPXSA-UHFFFAOYSA-L manganese(2+);n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide;dichloride Chemical compound Cl[Mn]Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl OXOKTPUZOHPXSA-UHFFFAOYSA-L 0.000 claims abstract description 71
- 239000004480 active ingredient Substances 0.000 claims abstract description 26
- 239000000375 suspending agent Substances 0.000 claims abstract description 21
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 17
- 239000000839 emulsion Substances 0.000 claims abstract description 13
- 239000000725 suspension Substances 0.000 claims abstract description 13
- 229910021380 Manganese Chloride Inorganic materials 0.000 claims description 69
- 239000011565 manganese chloride Substances 0.000 claims description 69
- 229940099607 manganese chloride Drugs 0.000 claims description 69
- 239000005842 Thiophanate-methyl Substances 0.000 claims description 59
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 claims description 59
- 239000000843 powder Substances 0.000 claims description 39
- 238000009736 wetting Methods 0.000 claims description 35
- 239000002131 composite material Substances 0.000 claims description 33
- 230000000844 anti-bacterial effect Effects 0.000 claims description 29
- 238000009472 formulation Methods 0.000 claims description 13
- 239000000470 constituent Substances 0.000 claims description 9
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 abstract description 13
- 150000003839 salts Chemical class 0.000 abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 239000004563 wettable powder Substances 0.000 abstract 2
- 241001133184 Colletotrichum agaves Species 0.000 abstract 1
- 244000299906 Cucumis sativus var. sativus Species 0.000 abstract 1
- 241001006642 Venturia pyrina Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 69
- 241000207199 Citrus Species 0.000 description 26
- 235000020971 citrus fruits Nutrition 0.000 description 26
- 238000012360 testing method Methods 0.000 description 25
- 244000141359 Malus pumila Species 0.000 description 24
- 235000011430 Malus pumila Nutrition 0.000 description 24
- 235000015103 Malus silvestris Nutrition 0.000 description 24
- 206010039509 Scab Diseases 0.000 description 21
- 235000013399 edible fruits Nutrition 0.000 description 20
- 239000003795 chemical substances by application Substances 0.000 description 19
- 241000223600 Alternaria Species 0.000 description 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 15
- 201000010099 disease Diseases 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- -1 antifreeze Substances 0.000 description 13
- 240000008067 Cucumis sativus Species 0.000 description 12
- 230000003449 preventive effect Effects 0.000 description 12
- 241001672694 Citrus reticulata Species 0.000 description 10
- 240000001987 Pyrus communis Species 0.000 description 9
- 235000014443 Pyrus communis Nutrition 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 239000002270 dispersing agent Substances 0.000 description 9
- 230000002045 lasting effect Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 229920001285 xanthan gum Polymers 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 206010067482 No adverse event Diseases 0.000 description 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 8
- 239000005864 Sulphur Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- 230000001018 virulence Effects 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 6
- 230000002528 anti-freeze Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229940000406 drug candidate Drugs 0.000 description 6
- 239000003777 experimental drug Substances 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 229920002545 silicone oil Polymers 0.000 description 6
- 229920001732 Lignosulfonate Polymers 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 238000000498 ball milling Methods 0.000 description 5
- 239000007859 condensation product Substances 0.000 description 5
- 239000013530 defoamer Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 229920005646 polycarboxylate Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 235000013311 vegetables Nutrition 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- 241000221785 Erysiphales Species 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 235000009754 Vitis X bourquina Nutrition 0.000 description 4
- 235000012333 Vitis X labruscana Nutrition 0.000 description 4
- 240000006365 Vitis vinifera Species 0.000 description 4
- 235000014787 Vitis vinifera Nutrition 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 239000000440 bentonite Substances 0.000 description 4
- 229910000278 bentonite Inorganic materials 0.000 description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000006184 cosolvent Substances 0.000 description 4
- 230000035613 defoliation Effects 0.000 description 4
- 239000007884 disintegrant Substances 0.000 description 4
- 230000000855 fungicidal effect Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000004996 alkyl benzenes Chemical class 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 238000004166 bioassay Methods 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000000205 computational method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 239000002420 orchard Substances 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000005802 Mancozeb Substances 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- GQBJGCRYICJRII-UHFFFAOYSA-N formaldehyde 2-(2-phenylethyl)phenol Chemical compound C=O.C1(=CC=CC=C1)CCC1=C(C=CC=C1)O GQBJGCRYICJRII-UHFFFAOYSA-N 0.000 description 1
- 229940084434 fungoid Drugs 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000001741 organic sulfur group Chemical group 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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Abstract
The invention provides captan sterilization composition which comprises an effective active ingredient A and an effective active ingredient B, wherein the effective active ingredient A is captan, the effective active ingredient B is one of thiophonate-methyl, prochloraz and Prochloraz manganese, and the sterilization composition comprises the following ingredients (by weight): 2-78 percent of effective active ingredient A, i.e., captan, 2-78 percent of effective active ingredient B, i.e., thiophonate-methyl, prochloraz and Prochloraz manganese, and accessory ingredient and excipient for the rest. The composition of the captan and the thiophonate-methy can be made into wettable powder, water dispersible granules and suspending agent, and can be used for preventing and treating anthracnose of cucumber, alternania mail Roberts and venturia pirina with remarkable synergism; the composition of the captan, the prochloraz and the salt thereof can be made into wettable powder, water dispersible granules, suspending agent and suspension emulsion and can be used for preventing and treating anthracnose of citrus trees with remarkable synergism.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to the composite bactericidal composition of a kind of captan and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex, be used to prevent and treat pear scab, alternaria leaf spot of apple, powdery mildew of cucumber, citrus anthracnose.
Technical background
Fungi is topmost phytopathogen, and the plant disease more than 70% all is by fungus-caused, and because of its paathogenic factor complexity, difficulty of prevention and cure is very big.In recent years, along with the adjustment of rural area pattern of farming, fruit tree, growing vegetables area constantly increase, and the occurrence degree of many fungal diseases also increases thereupon on fruit tree, the vegetables, has caused enormous economic loss.
The apple tree spot defoliation: apple is the fruit variety of China's cultivated area maximum, but because fungoid diseases such as alternaria leaf spot of apple, scab take place seriously, and be difficult to control, make China orchard worker all suffer enormous economic loss every year, the economic loss that only causes because of alternaria leaf spot of apple, scab harm in China every year is up to more than 3,000,000,000 RMB according to statistics.At present, because the orchard worker uses old medicament always, prevent and treat as using medicaments such as for many years methyl Tobe Feng, mancozeb, resistance rises very fast, preventive effect constantly descends, it is more and more heavier to cause fungal diseases such as alternaria leaf spot of apple, scab to take place, and the bactericide kind of seeking new preventive effect excellence seems very urgent.
Cucumber anthracnose: be to threaten one of maximum disease on the cucumber, all can large tracts of land take place every year, distributed pole extensively and extremely difficult control, present single agent product can't effectively have been controlled disease and take place, and continues in rising trend in some areas incidence.
Pear scab: be a kind of quarantine venereal disease evil, mainly directly invade from plant leaf blade, fruit, the climing epidermis of stem, also can invade from pore and wound, sick portion begins depression to occur, is the silly shape of dun sore, and flow out translucent jelly, then become amber, diseased tissues stops growing, bending, when not deliquescing, without putrefaction, high humidity, sick portion produces the mould layer of black.
Citrus anthracnose: anthracnose is the modal diseases of oranges and tangerines, it has the advantages that harm is wide and the harm time is long, main harm blade, branch, flower, fruit and carpopodium often cause that oranges and tangerines kinds such as tangerine and orange class are fallen leaves in a large number, branch is withered, a large amount of fallen flowers, shedding and fruit rot.In the suitable area of condition, can endanger oranges and tangerines throughout the year.
Captan, (having another name called Cape Town, Gai Pudan) English name: captan, molecular formula: C
9H
8Cl
3NO
2S, chemical name: N-trichloro-methylthio-4-cyclohexene-1, the 2-dicarboximide, structural formula:
Captan is a kind of organic sulfur series bactericidal agent of the eastern cotton company of Japan development, has protection and therapeutic action concurrently.Its mechanism of action mainly is the metabolism that influences the pathogene pyruvic acid, and plurality of enzymes is had the obvious suppression effect, thereby the content that also can reduce adenosine triphosphate in the pathogene stops the conidial bulk storage of germ.Can be widely used in diseases such as powdery mildew on control wheat, barley, grape, fruit tree, vegetables and all kinds of economic crops, scab, anthracnose, spot defoliation, downy mildew.
The agent of captan list is used for a long time, and disease is developed immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
Captan of the present invention and thiophanate-methyl or Prochloraz and salt complex preparation thereof can be used for preventing and treating the multiple diseases on fruit tree, the vegetables, and crop is had excellent protection and therapeutic action, and field trial has showed extremely strong antibiotic and bactericidal activity.
The present invention realizes in the following manner:
A kind of Synergistic bactericidal composition that contains captan is characterized in that this bactericidal composition contains by weight percentage 2～78% effective constituents A captan and 2～78% active ingredient B.
The described Synergistic bactericidal composition that contains captan, it is characterized in that: active component B is selected from: a kind of in thiophanate-methyl, Prochloraz or the prochloraz-manganese chloride complex.
The described Synergistic bactericidal composition that contains captan is characterized in that: the percentage by weight of active component captan and thiophanate-methyl is 5～60: 5～75.
The described Synergistic bactericidal composition that contains captan is characterized in that: the percentage by weight of active component captan and thiophanate-methyl is 10～40: 10～50.
The described Synergistic bactericidal composition that contains captan is characterized in that: the percentage by weight of active component captan and Prochloraz or prochloraz-manganese chloride complex is 5～60: 5～45.
The described Synergistic bactericidal composition that contains captan is characterized in that: the percentage by weight of active component captan and Prochloraz or prochloraz-manganese chloride complex is 10～50: 10～30.
The described Synergistic bactericidal composition that contains captan is characterized in that: the formulation of the bactericidal composition that effective constituents A captan and active ingredient B thiophanate-methyl are composite is selected from: wetting powder, water dispersible granules, suspending agent.
The described Synergistic bactericidal composition that contains captan is characterized in that: the formulation of the combination sterilization composition of effective constituents A captan and active ingredient B Prochloraz or prochloraz-manganese chloride complex is selected from: wetting powder, water dispersible granules, suspending agent, suspension emulsion.
The described Synergistic bactericidal composition that contains captan is characterized in that auxiliary agent and excipients comprise: dispersant, wetting agent, disintegrant, thickener, antifreeze, preservative, defoamer, emulsifier, cosolvent, filler.
The described Synergistic bactericidal composition that contains captan, it is characterized in that: when effective constituents A captan and active ingredient B thiophanate-methyl are mixed, contain when making wetting powder: captan 2～78%, thiophanate-methyl 2～78%, dispersant 3～10%, wetting agent 1～5%, filler surplus; Comprise when making water dispersible granules: captan 2～78%, thiophanate-methyl 2～78%, dispersant 3～10%, wetting agent 1～10%, disintegrant 1～5%, filler surplus; Comprise when making suspending agent: captan 2～78%, thiophanate-methyl 2～78%, dispersant 3～10%, antifreezing agent 1～5%, thickener 0.1～2%, defoamer 0.1～0.5%, deionized water surplus.
The described Synergistic bactericidal composition that contains captan, it is characterized in that: when effective constituents A captan and active ingredient B Prochloraz or prochloraz-manganese chloride complex are mixed, comprise when it is characterized in that making wetting powder: captan 2～78%, Prochloraz (prochloraz-manganese chloride complex) 2～78%, dispersant 3～10%, wetting agent 1～5%, filler surplus; Comprise when making water dispersible granules: captan 2～78%, Prochloraz or prochloraz-manganese chloride complex 2～78%, dispersant 3～10%, wetting agent 1～10%, disintegrant 1～5%, filler surplus; Comprise when making suspension emulsion: captan 2～78%, Prochloraz (prochloraz-manganese chloride complex) 2～78%, dispersant 3～10%, wetting agent 1～10%, antifreezing agent 1～5%, thickener 0.1～2%, defoamer 0.1～0.5%, cosolvent 2.5%-5%, emulsifier 3%-5%, deionized water surplus; Comprise when making suspending agent: captan 2～78%, Prochloraz (prochloraz-manganese chloride complex) 2～78%, dispersant 3～10%, antifreezing agent 1～5%, thickener 0.1～2%, defoamer 0.1～0.5%, deionized water surplus.
Above-mentioned formulation material is mixed, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder of the present composition.
Formulation material is mixed, pulverize, carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis, make the water dispersible granules of the present composition through mediating, adding then with micro jet.
With in the above-mentioned formulation material except that crossing all the other components of active ingredient, mix through high speed shear, adding active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes the suspending agent of the present composition.
With all the other components except that crossing active ingredient, cosolvent, emulsifier in the above-mentioned formulation material, ball milling is 2～3 hours in ball mill, and homogeneous mixes and to get final product, with active ingredient add cosolvent, emulsifier mixes, two mixtures evenly mix the most at last, make the suspension emulsion of the present composition.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, DBSA, Nekal BX, wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described emulsifier is selected from: one or more in calcium dodecyl benzene sulfonate, phenethyl phenol polyethenoxy ether phosphate, phenethyl phenol formaldehyde resin APEO, phenolic ether phosphate, fatty alcohol-polyoxyethylene ether, the fatty alcohol formaldehyde APEO.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
It is remarkable that the described bactericidal composition that contains captan is used to prevent and treat cucumber anthracnose, alternaria leaf spot of apple, pear scab, citrus anthracnose effect, compares with single agent, has obvious synergistic effect.
The present invention has following characteristics:
1, double action mechanism, germ are difficult for producing resistance;
2, synergistic effect is obvious.Indoor biometrics is tested the result and shown: captan and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex are composite by a certain percentage to have clearly synergistic effect to crop pest;
3, enlarge fungicidal spectrum.The composite multiple main disease of preventing and treating on fruit tree, the vegetables of captan and thiophanate-methyl or Prochloraz and salt thereof, as ring rot of apple, alternaria leaf spot of apple, apple mildew, apple anthracnose, citrus anthracnose, powdery mildew of cucumber, cucumber anthracnose, pear scab, apple tree scab etc., enlarged fungicidal spectrum.
4, belong to environment friendly agricultural.Captan, Prochloraz and salt thereof, thiophanate-methyl all belong to low-toxin farm chemicals, its complex preparation, and high-efficiency low-toxicity to crop and Environmental security, helps the sustainable development of agricultural production.
Embodiment
The present invention will be further described for following examples, but the present invention is not limited thereto.
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.By indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial more earlier.
Implementation of an application example one captan and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex different proportion are used the Toxicity Determination to alternaria leaf spot of apple, citrus anthracnose with
1, experimental condition
The former bacterium of alternaria leaf spot of apple: the alternaria leaf spot of apple bacterial classification that indoor 4 ℃ of refrigerators are preserved is transferred on the PDA medium, in 28 ℃ of incubators, cultivate and make its activation, through standby after twice switching.
The former bacterium of citrus anthracnose: the alternaria leaf spot of apple bacterial classification that indoor 4 ℃ of refrigerators are preserved is transferred on the PDA medium, in 28 ℃ of incubators, cultivate and make its activation, through standby after twice switching.
2, test medicine
The former medicine of captan, content 92% (Shaanxi Welch Crop Protection Co., Ltd. provides)
The former medicine of thiophanate-methyl, content 95% (Shaanxi Welch Crop Protection Co., Ltd. provides)
The former medicine of Prochloraz, content 98% (Shaanxi Welch Crop Protection Co., Ltd. provides)
The former medicine of prochloraz-manganese chloride complex, content 95% (Shaanxi Welch Crop Protection Co., Ltd. provides)
3, experiment is handled
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast, and concrete treatment dosage is as follows:
Captan 0.5,1,2,5,10 μ g/mL
Thiophanate-methyl 0.5,1,2,5,10 μ g/mL
Prochloraz 0.1,0.2,0.5,1,2 μ g/mL
Prochloraz-manganese chloride complex 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (39: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (12: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (4: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (4: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (1: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (1: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (1: 15) 0.1,0.2,0.5,1,2 μ g/mL
Captan: first sulphur (1: 39) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (39: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (12: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (4: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (4: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (3: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (1: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (1: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: Prochloraz (1: 39) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (39: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (12: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (4: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (4: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (3: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (1: 1) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (1: 5) 0.1,0.2,0.5,1,2 μ g/mL
Captan: prochloraz-manganese chloride complex (1: 39) 0.1,0.2,0.5,1,2 μ g/mL
Each concentration is handled and is repeated 4 times.
4, test method
Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ".This experiment adopts the mycelial growth rate method to measure the virulence of medicament to alternaria leaf spot of apple bacterium and citrus anthracnose bacterium.Concrete grammar is as follows: the alternaria leaf spot of apple bacteria strain through switching activation is cultivated with PDA, when treating that bacterium colony grows to culture dish 3/4ths sizes, is that the card punch of 5mm punches from the edge with internal diameter, and the mycelia piece that breaks into is as inoculum.The soup 4ml that respectively handles that gets the concentration for preparing respectively and be 10 times of above-mentioned design concentrations evenly mixes with quantitative 36ml sterilization PDA medium, divide and pour in 3 sterilization culture dishes, make the pastille flat board after the cooling, be mixed into contrast, 4 repetitions of every Treatment Design with equivalent aqua sterilisa and culture dish.To inoculate mycelia and be inverted in dull and stereotyped central authorities, and put into 28 ℃ of incubators and cultivate.Measure colony diameter with the right-angled intersection method behind the 96h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
5, calculate
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively captan and thiophanate-methyl or Prochloraz and salt thereof shared ratio in combination
A is a captan
B is thiophanate-methyl or Prochloraz and salt thereof
6, experimental result and analysis
Table 1 captan, thiophanate-methyl and use toxicity test analysis of results table with to alternaria leaf spot of apple
As shown in Table 1, captan, thiophanate-methyl are to the EC of alternaria leaf spot of apple germ
50Be respectively 0.68 μ g/mL and 0.56 μ g/mL.The virulence of thiophanate-methyl is higher than the virulence of captan.39: 1 to 1: 39 synergy ratio of captan and thiophanate-methyl proportioning shows as synergistic effect entirely greater than 1.5, especially when captan and thiophanate-methyl proportioning at 12: 1 between 1: 5 the time, synergistic effect is the most obvious,
Table 2 captan, Prochloraz and use toxicity test analysis of results table with to citrus anthracnose
As shown in Table 2, captan, Prochloraz are to the EC of citrus anthracnose
50Be respectively 0.68 μ g/mL and 0.42 μ g/mL.The virulence of Prochloraz is apparently higher than the virulence of captan.39: 1 to 1: 39 synergy ratio of captan and Prochloraz proportioning shows as synergistic effect entirely greater than 1.5, especially when captan and Prochloraz proportioning at 12: 1 between 4: 5 the time, synergistic effect is the most obvious.
Table 3 captan, prochloraz-manganese chloride complex and use toxicity test analysis of results table with to citrus anthracnose
As shown in Table 3, the EC of captan, prochloraz-manganese chloride complex salt pair citrus anthracnose
50Be respectively 0.71 μ g/mL and 0.44 μ g/mL.The virulence of prochloraz-manganese chloride complex is apparently higher than the virulence of captan.39: 1 to 1: 39 synergy ratio of captan and Prochloraz proportioning shows as synergistic effect entirely greater than 1.5, especially when captan and Prochloraz proportioning at 12: 1 between 4: 5 the time, synergistic effect is the most obvious.
Implementation of an application example two captans and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex compounded formula and field control effectiveness test (following content is all to roll over hundred)
Embodiment 1:80% captan thiophanate-methyl wetting powder
Get the former medicine 40g of captan, the former medicine 40g of thiophanate-methyl, lignosulfonates 4g, Nekal BX 3g, neopelex 4g, white carbon adds to 100g, place agitator to stir, promptly can be made into 80% captan thiophanate-methyl wetting powder to 500 orders through comminution by gas stream.
80% captan thiophanate-methyl wetting powder control apple tree spot defoliation field trial.
1, test medicine
80% captan thiophanate-methyl wetting powder (Shaanxi Welch Crop Protection Co., Ltd. provides)
2, contrast medicament
50% captan wetting powder
70% thiophanate-methyl wetting powder
3, dosing and processing numbering
Table 4 reagent agent experimental scheme
4, spraying time and number of times
Totally 6 dispensers were executed medicine for the first time on May 25, afterwards respectively in June 11, June 24, July 11, July 24, dispenser on August 4.
5, control time and method
Radix investigation (May 25) before the dispenser, the complete disease-free generation in garden before the medicine, June 24 and August 16 investigate twice respectively, investigate altogether 3 times.
The all investigation of every sub-district two strains tree, every strain is fixed two by east, south, west, north, middle five positions and is taken out the vigorous branch of life then, stops to take out living phase and autumn growth slightly in the spring and stops to take out the living phase and regularly investigate, and writes down total number of sheets, the sick numbers of sheets at different levels.
Grade scale:
0 grade: no scab;
1 grade: lesion area accounts for below 10% of whole leaf area;
3 grades: lesion area accounts for 11%～25% of whole leaf area;
5 grades: lesion area accounts for 26%～40% of whole leaf area;
7 grades: lesion area accounts for 41%～65% of whole leaf area;
9 grades: lesion area accounts for more than 66% of whole leaf area.
6, drug effect computational methods
In the formula: disease index after the district's dispenser of CK-blank;
Disease index after the district's dispenser of PT-chemicals treatment;
7, test results and analysis
The composite control alternaria leaf spot of apple of table 5 captan and thiophanate-methyl result of the test
As shown in Table 5, captan and thiophanate-methyl are composite remarkable to the alternaria leaf spot of apple control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period, in the test scope of medication, the target crop are had no adverse effects.
Embodiment 2:55% captan Prochloraz wetting powder
Get the former medicine 10g of captan, the former medicine 45g of Prochloraz, alkyl benzene sulfonate calcium salt 8g, lauryl sodium sulfate 4g, white carbon 10g, diatomite adds to 100g, place agitator to stir, promptly can be made into 55% captan Prochloraz spirit wetting powder to 500 orders through comminution by gas stream.Embodiment 3:80% captan prochloraz-manganese chloride complex wetting powder
Get the former medicine 60g of captan, the former medicine 20g of prochloraz-manganese chloride complex, polycarboxylate 8g, alkylnaphthalene sulfonate 4g, kaolin adds to 100g, places agitator to stir, and promptly can be made into 80% captan prochloraz-manganese chloride complex wetting powder through comminution by gas stream to 500 orders.
55% captan Prochloraz wetting powder, 80% captan prochloraz-manganese chloride complex wetting powder control mandarin tree anthracnose field trial.
1, test medicine
55% captan Prochloraz wetting powder (Shaanxi Welch Crop Protection Co., Ltd. provides)
80% captan prochloraz-manganese chloride complex wetting powder (Shaanxi Welch Crop Protection Co., Ltd. provides)
2, contrast medicament
50% captan wetting powder
50% Prochloraz wetting powder
50% prochloraz-manganese chloride complex wetting powder
2, dosing and processing numbering
Table 6 reagent agent experimental scheme
4, spraying time and number of times
Totally three dispensers, July 15 is dispenser for the first time when disease just takes place, carry out respectively on July 29 and August 10, August 25 for the second time, for the third time with the 4th dispenser.
5, control time and method
July 15 was carried out the investigation of state of an illness radix before the dispenser, and carry out efficacy survey behind the medicine 15 days (September 9) behind the 4th medicine.
According to mandarin tree fruit hazard symptoms grading.The all investigation of every sub-district 2 strains tree.From the East, West, South, North of every strain tree, 5 get 50 fruits respectively and investigate.And carry out classification by following grade scale, write down total fruit tree and sick fruit tree at different levels.
0 grade: do not have scab on the fruit;
1 grade: have scab 1-2 on the fruit;
3 grades: have scab 3-4 on the fruit;
5 grades: have scab 5-6 on the fruit;
7 grades: have scab 7-10 on the fruit;
9 grades: have on the fruit scab more than 10 or scab link to each other, account for the fruit area more than 1/4.
6, drug effect computational methods
In the formula: CK
0Disease index before the dispenser of-blank district;
CK
1Disease index after the dispenser of-blank district;
PT
0Disease index before the dispenser of-chemicals treatment district;
PT
1Disease index after the dispenser of-chemicals treatment district.
7, test results and analysis
The composite control citrus anthracnose of table 7 captan and Prochloraz or prochloraz-manganese chloride complex result of the test
As shown in Table 7, captan and Prochloraz or prochloraz-manganese chloride complex are composite remarkable to the citrus anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period, in the test scope of medication, the target crop are had no adverse effects.
Embodiment 4:80% captan thiophanate-methyl water dispersible granules
Get the former medicine 30g of captan, the former medicine 50g of thiophanate-methyl, sodium lignin sulfonate 4g, lauryl sodium sulfate 3g, sodium bicarbonate 4g, bentonite 4g, starch adds to 100g, and formulation material is mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis can be made into 80% captan thiophanate-methyl water dispersible granules.
Embodiment 5:60% captan prochloraz-manganese chloride complex water dispersible granules
Get the former medicine 40g of captan, the former medicine 20g of prochloraz-manganese chloride complex, polycarboxylic acids sodium 3g, sodium lignin sulfonate 2g, draw back powder 5g, urea 5g, white carbon 5g, starch adds to 100g, formulation material is mixed, pulverize, through mediating with micro jet, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis can be made into 60% captan prochloraz-manganese chloride complex water dispersible granules.
The composite control cucumber anthracnose of captan and thiophanate-methyl test of pesticide effectiveness result such as table 8:
The composite control cucumber anthracnose of table 8 captan and thiophanate-methyl result of the test
As shown in Table 8, captan and thiophanate-methyl, captan and prochloraz-manganese chloride complex are composite remarkable to the cucumber anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range, to cucumber safety, have no adverse effects, the inventor also finds that the invention preparation has good control efficiency to powdery mildew of cucumber.
Embodiment 6:20% captan thiophanate-methyl suspending agent
Get the former medicine 10g of captan, the former medicine 10g of thiophanate-methyl, lignosulfonates 8g, neopelex 5g, ethylene glycol 3g, benzoic acid 0.8g, xanthans 0.1g, silicone defoaming agent 0.1g, water surplus.With in the above-mentioned formulation material except that crossing all the other components of active ingredient, mix through high speed shear, adding active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes 20% captan thiophanate-methyl suspending agent.
The composite control pear scab of captan and thiophanate-methyl test of pesticide effectiveness result such as table 9:
The composite control pear scab of table 9 captan and thiophanate-methyl result of the test
As shown in Table 9, captan and thiophanate-methyl are composite remarkable to the pear scab control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range,, have no adverse effects to pear tree safety.
Embodiment 7:40% captan Prochloraz suspending agent
Get the former medicine 10g of captan, the former medicine 30g of Prochloraz, alkyl benzene calcium sulfonate 5g, lauryl sodium sulfate 4g, glycerine 3g, Sodium Benzoate 0.8g, xanthans 0.1g, silicone compound 0.1g, water surplus.Back in the above-mentioned formulation material except that crossing all the other components of active ingredient, is mixed through high speed shear, adding active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes 40% captan Prochloraz suspending agent.
The composite control citrus anthracnose of captan and Prochloraz test of pesticide effectiveness result such as table 9:
The composite control citrus anthracnose of table 10 captan and Prochloraz result of the test
As shown in Table 10, captan and Prochloraz are composite remarkable to the citrus anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range,, have no adverse effects to oranges and tangerines safety.
Embodiment 8:50% captan prochloraz-manganese chloride complex suspending agent
Get the former medicine 45g of captan, the former medicine 5g of prochloraz-manganese chloride complex, polyoxyethylene aryl phenyl ether phosphate 5g, soapberry powder 3g, ethylene glycol 2g, aluminium-magnesium silicate 0.8g, xanthans 0.1g, silicone oil 0.1g, potassium sorbate 1g, water surplus.Back in the above-mentioned formulation material except that crossing all the other components of active ingredient, is mixed through high speed shear, adding active ingredient, ball milling is 2～3 hours in ball mill, makes particle diameter all below 5 μ m, makes 50% captan prochloraz-manganese chloride complex suspending agent.
The composite control citrus anthracnose of captan and prochloraz-manganese chloride complex test of pesticide effectiveness result such as table 11:
The composite control citrus anthracnose of table 11 captan and prochloraz-manganese chloride complex result of the test
As shown in Table 11, captan and prochloraz-manganese chloride complex are composite remarkable to the citrus anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range,, have no adverse effects to oranges and tangerines safety.
Embodiment 9:20% captan Prochloraz suspension emulsion
Get the former medicine 10g of captan, the former medicine 10g of Prochloraz, polycarboxylate 5g, lauryl sodium sulfate 3g, ethylene glycol 1g, silicone compound 0.8g, xanthans 0.1g, potassium sorbate 0.1g, fatty alcohol formaldehyde APEO 1g, water surplus.The mixed 20% captan Prochloraz suspension emulsion that gets.
The composite control citrus anthracnose of captan and Prochloraz test of pesticide effectiveness result such as table 12:
The composite control citrus anthracnose of table 12 captan and Prochloraz result of the test
As shown in Table 12, captan and Prochloraz are composite remarkable to the citrus anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range,, have no adverse effects to oranges and tangerines safety.
Embodiment 10:35% captan prochloraz-manganese chloride complex suspension emulsion
Get the former medicine 5g of captan, the former medicine 30g of prochloraz-manganese chloride complex, lignosulfonates 5g, lauryl sodium sulfate 3g, glycerine 1g, silicone oil 0.8g, xanthans 0.1g, phenolic ether phosphate 1g, water surplus.The mixed 35% captan prochloraz-manganese chloride complex suspension emulsion that gets.
The composite control citrus anthracnose of captan and prochloraz-manganese chloride complex test of pesticide effectiveness result such as table 13:
The composite control citrus anthracnose of table 13 captan and prochloraz-manganese chloride complex result of the test
As shown in Table 13, captan and prochloraz-manganese chloride complex are composite remarkable to the citrus anthracnose control efficiency, compare with single agent, have preventive effect height, long, residual little advantage of lasting period.In this experimental drug weight range,, have no adverse effects to oranges and tangerines safety.
Embodiment 11:80% captan thiophanate-methyl wetting powder
Get the former medicine 78g of captan, the former medicine 2g of thiophanate-methyl, polycarboxylate 4g, neopelex 5g, white carbon 6g, kaolin adds to 100g, the mixed 80% captan thiophanate-methyl wetting powder that gets.
Embodiment 12:50% captan Prochloraz wetting powder
Get the former medicine 35g of captan, the former medicine 15g of Prochloraz, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 5g, wetting and penetrating agent F 4g, white carbon 6g, kaolin adds to 100g, the mixed 50% captan Prochloraz wetting powder that gets.
Embodiment 13:60% captan prochloraz-manganese chloride complex wetting powder
Get the former medicine 48g of captan, the former medicine 12g of prochloraz-manganese chloride complex, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4g, silkworm excrement 5g, diatomite 5g, bentonite adds to 100g, the mixed 60% captan prochloraz-manganese chloride complex wetting powder that gets.
Embodiment 14:80% captan thiophanate-methyl water dispersible granules
Get the former medicine 2g of captan, the former medicine 78g of thiophanate-methyl, polycarboxylate 4g, soapberry powder 4g, citric acid 3g, methylcellulose 2g, starch adds to 100g, the mixed 80% captan thiophanate-methyl water dispersible granules that gets.
Embodiment 15:80% captan prochloraz-manganese chloride complex water dispersible granules
Get the former medicine 75g of captan, the former medicine 5g of prochloraz-manganese chloride complex, aliphatic amine polyoxyethylene ether 5g, spaonin powder 4g, ammonium sulfate 4g, polyvinyl alcohol 2g, starch adds to 100g, the mixed 80% captan prochloraz-manganese chloride complex water dispersible granules that gets.
Embodiment 16:43% captan thiophanate-methyl suspending agent
Get the former medicine 38g of captan, the former medicine 5g of thiophanate-methyl, alkylphenol polyoxyethylene 4g, Nekal BX 3g, antifreeze ethylene glycol 3g, silicone oil 0.5g, xanthans 0.1g, deionized water surplus.The mixed 43% captan thiophanate-methyl suspending agent that gets.
Embodiment 17:48% captan Prochloraz suspending agent
Get the former medicine 40g of captan, the former medicine 8g of Prochloraz, fatty acid glyceride APEO 4g, polyoxyethylene triphenylethylene phosphenylic acid salt 4g, antifreeze propane diols 3g, silicone 0.5g, carboxymethyl cellulose 0.1g, deionized water surplus.The mixed 48% captan Prochloraz suspending agent that gets.
Embodiment 18:40% captan prochloraz-manganese chloride complex suspending agent
Get the former medicine 30g of captan, the former medicine 10g of prochloraz-manganese chloride complex, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4g, spaonin powder 3g, antifreeze glycerine 2g, silicone oil 0.2g, aluminium-magnesium silicate 0.8g, deionized water surplus.The mixed 40% captan prochloraz-manganese chloride complex suspending agent that gets.
Embodiment 19:30% captan Prochloraz suspension emulsion
Get the former medicine 15g of captan, the former medicine 15g of Prochloraz, polyoxyethylene carboxylate 6g, wetting and penetrating agent F 5g, silicone 0.5g, xanthans 0.1g, phenethyl phenol polyethenoxy ether phosphate 4g, antifreeze propane diols 3g, deionized water surplus.The mixed 30% captan Prochloraz suspension emulsion that gets.
Embodiment 20:20% captan prochloraz-manganese chloride complex suspension emulsion
Get the former medicine 2g of captan, the former medicine 18g of prochloraz-manganese chloride complex, lignosulfonates 5g, alkylnaphthalene sulfonate 4g, silicone oil 0.8g, xanthans 0.1g, fatty alcohol-polyoxyethylene ether 5g, water surplus.The mixed 20% captan prochloraz-manganese chloride complex suspension emulsion that gets.
Embodiment 11-20 prevents and treats the bitter rot or anthracnose of grape test of pesticide effectiveness
Test medicine: the composite product of captan and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex (Shaanxi Welch Crop Protection Co., Ltd. provides)
Contrast medicament: 50% captan wetting powder; 25% Prochloraz missible oil; 50% prochloraz-manganese chloride complex wetting powder (commercial)
Table 14 captan and the composite bitter rot or anthracnose of grape result of the test of preventing and treating thereof
By above-mentioned experimental results show that; after captan and thiophanate-methyl, Prochloraz or prochloraz-manganese chloride complex are composite; control apple tree spot defoliation, cucumber anthracnose, pear scab, citrus anthracnose, bitter rot or anthracnose of grape have good synergistic effect; and enlarged fungicidal spectrum; one medicine is controlled more; saved medication and recruitment cost, good to environmental protection property.
Claims (8)
1. Synergistic bactericidal composition that contains captan is characterized in that this bactericidal composition contains by weight percentage 2～78% effective constituents A captan and 2～78% active ingredient B.
2. according to the described Synergistic bactericidal composition that contains captan of claim 1, it is characterized in that: active ingredient B is selected from a kind of in thiophanate-methyl, Prochloraz or the prochloraz-manganese chloride complex.
3. according to the described Synergistic bactericidal composition that contains captan of claim 1, it is characterized in that: the percentage by weight of active component captan and thiophanate-methyl is 5～60: 5～75.
4. according to the described Synergistic bactericidal composition that contains captan of claim 3, it is characterized in that: the percentage by weight of active component captan and thiophanate-methyl is 10～40: 10～50.
5. according to the described Synergistic bactericidal composition that contains captan of claim 1, it is characterized in that: the percentage by weight of active component captan and Prochloraz or prochloraz-manganese chloride complex is 5～60: 5～45.
6. according to the described Synergistic bactericidal composition that contains captan of claim 5, it is characterized in that: the percentage by weight of active component captan and Prochloraz or prochloraz-manganese chloride complex is 10～50: 10～30.
7. according to the described Synergistic bactericidal composition that contains captan of claim 1, it is characterized in that: the formulation of the bactericidal composition that effective constituents A captan and active ingredient B thiophanate-methyl are composite is selected from: wetting powder, water dispersible granules, suspending agent.
8. according to the described Synergistic bactericidal composition that contains captan of claim 1, it is characterized in that: the formulation of the combination sterilization composition of effective constituents A captan and active ingredient B Prochloraz or prochloraz-manganese chloride complex is selected from: wetting powder, water dispersible granules, suspending agent, suspension emulsion.
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| WO2013175467A1 (en) * | 2012-05-24 | 2013-11-28 | Makhteshim Chemical Works Ltd | Synergistic fungicidal composition |
| CN108925574A (en) * | 2017-05-22 | 2018-12-04 | 广东广康生化科技股份有限公司 | A kind of effective component includes the Bactericidal composite of captan and thiophanate-methyl |
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| WO2013175467A1 (en) * | 2012-05-24 | 2013-11-28 | Makhteshim Chemical Works Ltd | Synergistic fungicidal composition |
| CN102669181A (en) * | 2012-06-13 | 2012-09-19 | 江苏龙灯化学有限公司 | Sterilization composition containing captan and copper calcium sulfate and application of sterilization composition |
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