CN103734158A - Polyoxins-containing bactericidal composition - Google Patents
Polyoxins-containing bactericidal composition Download PDFInfo
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- CN103734158A CN103734158A CN201410007495.0A CN201410007495A CN103734158A CN 103734158 A CN103734158 A CN 103734158A CN 201410007495 A CN201410007495 A CN 201410007495A CN 103734158 A CN103734158 A CN 103734158A
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Abstract
The invention discloses a polyoxins-containing bactericidal composition which contains A and B, wherein the A is selected from polyoxins, the B is selected from any one of the following bactericides: ethirimol, JS399-19, bromothalonil, zineb, chlorothalonil and dithianon, and the weight ratio of the active components A and B is 32:1-1:64. The polyoxins-containing bactericidal composition can prevent and treat various crop diseases, has an obvious synergistic effect, enlarges the bactericidal spectrum, and has relatively high activities to diseases such as downy mildew, epidemic diseases, anthracnose, powdery mildew, leaf spot disease, gibberellic disease, rice blast, and the like; and the pesticide dosage is reduced, the residues of pesticides in crops are reduced, and the environment pollution is reduced.
Description
The application is for dividing an application, and original application is the patent application " a kind of bactericidal composition that contains polyoxin " of Shaanxi Mei Bang agricultural chemicals Co., Ltd, and the application number of original application is ︰ 201110043691.X, and original application day is 2011.02.23.
Technical field
The invention belongs to technical field of pesticide, relate to a kind of binary mixture bactericidal composition that contains polyoxin.
Background technology
Polyoxin (polyoxin), molecular formula: C
17h
25n
5o
14, chemical name: peptide pyrimidine nucleoside.
Structural formula:
Polyoxin broad-spectrum antibiotics class, in having preferably, inhale conduction, its mechanism of action is to disturb the chitinous biosynthesis of bacterial cell wall, after germ tube contacts medicament with mycelium, expand part, break, overflow cell inclusion, and can not normal development, cause death, suppress in addition germ and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had to poisoning.Main controlling object has wheat powdery mildew, Alternaria alternate, cucumber downy mildew, cucurbits fusarium wilt, black fleck disease of ginseng, rice seedling blight, alternaria leaf spot of apple, strawberry and work grape grey mould, the multiple fungal diseases such as forest spike top and Pear black spot.
Yet in the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the drug-fast generation of germ.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance germ.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery can produce good synergistic effect by polyoxin and the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon after composite, and not yet open about polyoxin and the composite relevant report of the phonetic phenol of glyoxaline compound second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon.
Summary of the invention
The object of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition containing polyoxin that use cost is low, preventive effect is good.
The bactericidal composition that the present invention proposes contains A, two kinds of active components of B.
Active component A is polyoxin.
Active component B is selected from following any one bactericide: the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn and dithianon.
The phonetic phenol of described second (ethirimol), molecular formula is C
11h
19n
3o, chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine.
Described zineb (zineb), molecular formula is C
4h
6n
2s
4zn, chemical name: zinc ethylenebisdithiocarbamate.
Described 2-cyano-3-amino-3-phenylancryic acetate, molecular formula is C
12h
12n
2o
2, chemical name: 2-cyano group-3-amino-3-aminoacrylic acid ethyl ester.
Described tpn (chlorothalonil), molecular formula is C
8cl
4n
2, chemical name: daconil M (2,4,5,6-tetrachloro-1,3-benzene dicarbonitrile).
Described bromothalonil (bromothalonil), molecular formula is C
6h
6br
2n
2, the bromo-2 bromomethyl glutaronitriles of chemical name: 2-.
Described dithianon (dithianon), molecular formula is C
14h
4n
2o
2s
2, chemical name: 2,3-dinitrile-Isosorbide-5-Nitrae-anthraquinone dithio.
A kind of bactericidal composition that contains polyoxin, comprise effective active component, auxiliary agent and filler, it is characterized in that: A, B percentage by weight are 32 ︰ 1 to 1 ︰ 64, active component A is selected from polyoxin, and active component B is the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon.
Described a kind of bactericidal composition that contains polyoxin, is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 8 ︰ 1 to 1 ︰ 32.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and the phonetic phenol of second is 8 ︰ 1 to 1 ︰ 8.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and zineb is 1 ︰ 1 to 1 ︰ 16.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and tpn is 1 ︰ 1 to 1 ︰ 16.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and 2-cyano-3-amino-3-phenylancryic acetate is 2 ︰ 1 to 1 ︰ 16.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and dithianon is 8 ︰ 1 to 1 ︰ 8.
The described bactericidal composition containing polyoxin, is characterized in that: the percentage by weight of polyoxin and bromothalonil is 1 ︰ 1 to 1 ︰ 16.
Conventionally in composition, active weight percentage is gross weight 1～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, binding agent or defoamer.According to different dosage form, in preparation, can also contain disintegrant known in those skilled in the art, antifreeze etc.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after being about to active substance and mixing with liquid flux or solid carrier, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules.
When making wetting powder, composition comprises following constituent content: polyoxin 1～35%, active component B1～80%, dispersant 5～10%, wetting agent 2～10%, filler add to 100%.
Active component polyoxin, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: active component polyoxin 1～35%, active component B1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler add to 100%.
Active component polyoxin, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make the water dispersible granules product of the present composition.
The invention has the advantages that: after the compound of (1) two kind of different sterilization mechanism is composite, there is notable synergistic and lasting effect; (2) expanded fungicidal spectrum, the diseases such as downy mildew, epidemic disease, anthracnose, powdery mildew, leaf spot, head blight, rice blast have all been had to greater activity; (3) the present invention not with an organic solvent, is difficult for producing poisoning, is convenient to transportation and storage; (4) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Embodiment 160% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder
Polyoxin 10%, 2-cyano-3-amino-3-phenylancryic acetate 50%, polyoxyethylene carboxylate 5%, Nekal BX 5%, bentonite add to 100%, and mixture carries out air-flow crushing, make 60% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder.
Embodiment 280% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder
Polyoxin 15%, 2-cyano-3-amino-3-phenylancryic acetate 65%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, lauryl sodium sulfate 4%, kaolin add to 100%, and mixture carries out air-flow crushing, make 80% polyoxin 2-cyano-3-amino-3-phenylancryic acetate wetting powder.
Embodiment 350% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Polyoxin 5%, 2-cyano-3-amino-3-phenylancryic acetate 45%, soapberry powder 6%, alkyl benzene sulfonate calcium salt 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 50% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Embodiment 430% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Polyoxin 5%, 2-cyano-3-amino-3-phenylancryic acetate 25%, wetting and penetrating agent F4%, lignosulfonates 5%, urea 0.6%, bentonite add to 100%, mix and make 30% polyoxin 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules.
Embodiment 960% polyoxin bromothalonil wetting powder
Polyoxin 10%, bromothalonil 50%, lignosulfonates 6%, wetting and penetrating agent F5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 60% polyoxin bromothalonil wetting powder.
Embodiment 1075% polyoxin bromothalonil wetting powder
Polyoxin 10%, bromothalonil 65%, alkyl benzene sulfonate calcium salt 5%, spaonin powder 4%, kaolin add to 100%, and mixture carries out air-flow crushing, make 75% polyoxin bromothalonil wetting powder.
Embodiment 1140% polyoxin bromothalonil water dispersible granules
Polyoxin 10%, bromothalonil 30%, alkylphenol-polyethenoxy are phonetic 7%, lauryl sodium sulfate 5%, aluminium chloride 0.5%, starch 15%, diatomite add to 100%, mix and make 40% polyoxin bromothalonil water dispersible granules.
Embodiment 1275% polyoxin bromothalonil water dispersible granules
Polyoxin 5%, bromothalonil 70%, polyoxyethylene carboxylate 6%, silkworm excrement 5%, urea 0.4%, bentonite add to 100%, mix and make 75% polyoxin bromothalonil water dispersible granules.
Embodiment 1760% polyoxin Zineb wettable powder
Polyoxin 10%, zineb 50%, aryl phenol polyoxyethylene succinate sulfonate 8%, wetting and penetrating agent F5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 60% polyoxin Zineb wettable powder.
Embodiment 1880% polyoxin Zineb wettable powder
Polyoxin 5%, zineb 75%, lignosulfonates 7%, spaonin powder 5%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow crushing, make 80% polyoxin Zineb wettable powder.
Embodiment 1950% polyoxin water dispersion granules agent of dithane
Polyoxin 3%, zineb 47%, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, mix and make 50% polyoxin water dispersion granules agent of dithane.
Embodiment 2065% polyoxin water dispersion granules agent of dithane
Polyoxin 1%, zineb 64%, lignosulfonates 3%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 65% polyoxin water dispersion granules agent of dithane.
Embodiment 2545% polyoxin tpn wetting powder
Polyoxin 2%, tpn 43%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 45% polyoxin tpn wetting powder.
Embodiment 2680% polyoxin tpn wetting powder
Polyoxin 6%, tpn 74%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, soapberry powder 6%, diatomite add to 100%, and mixture carries out air-flow crushing, make 80% polyoxin tpn wetting powder.
Embodiment 2736% polyoxin chlorothalonil water dispersible granule
Polyoxin 6%, tpn 30%, lignosulfonates 6%, wetting and penetrating agent F5%, ammonium sulfate 1.2%, bentonite add to 100%, mix and make 36% polyoxin chlorothalonil water dispersible granule.
Embodiment 2850% polyoxin chlorothalonil water dispersible granule
Polyoxin 2%, tpn 48%, alkylnaphthalene sulfonate 6%, spaonin powder 4%, ammonium sulfate 1%, bentonite add to 100%, mix and make 50% polyoxin chlorothalonil water dispersible granule.
The phonetic phenol wetting powder of embodiment 3360% polyoxin second
Polyoxin 20%, the phonetic phenol 40% of second, aryl phenol polyoxyethylene succinate sulfonate 6%, wetting and penetrating agent F5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make the phonetic phenol wetting powder of 60% polyoxin second.
The phonetic phenol wetting powder of embodiment 3430% polyoxin second
Polyoxin 10%, the phonetic phenol 20% of second, lignosulfonates 4%, spaonin powder 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make the phonetic phenol wetting powder of 30% polyoxin second.
Embodiment 3550% polyoxin ethirimol water dispersible granules
Polyoxin 10%, the phonetic phenol 40% of second, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, mix and make 50% polyoxin ethirimol water dispersible granules.
Embodiment 3620% polyoxin ethirimol water dispersible granules
Polyoxin 10%, the phonetic phenol 10% of second, lignosulfonates 4%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 20% polyoxin ethirimol water dispersible granules.
Embodiment 4145% polyoxin dithianon wetting powder
Polyoxin 5%, dithianon 40%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 45% polyoxin dithianon wetting powder.
Embodiment 4230% polyoxin dithianon wetting powder
Polyoxin 5%, dithianon 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, soapberry powder 6%, kaolin add to 100%, and mixture carries out air-flow crushing, make 30% polyoxin dithianon wetting powder.
Embodiment 4330% polyoxin dithianon water-dispersion granule
Polyoxin 6%, dithianon 24%, lignosulfonates 6%, spaonin powder 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 30% polyoxin dithianon water-dispersion granule.
Embodiment 4410% polyoxin dithianon water-dispersion granule
Polyoxin 8%, dithianon 2%, alkylnaphthalene sulfonate 6%, wetting and penetrating agent F4%, starch 2%, bentonite add to 100%, mix and make 10% polyoxin dithianon water-dispersion granule.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Polyoxin and active component B(B are selected from a kind of in the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon) the composite Toxicity Determination to target.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to target fungus.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component polyoxin and the phonetic phenol of B(second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon) shared ratio in combination;
A is polyoxin;
B is a kind of in the phonetic phenol of second, 2-cyano-3-amino-3-phenylancryic acetate, bromothalonil, zineb, tpn, dithianon.
Implementation of an application example two:
The phonetic phenol of polyoxin and second is composite to powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of the phonetic phenol of second and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 polyoxin, the phonetic phenol of second and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 1, polyoxin, the EC of the phonetic phenol of second to powdery mildew of cucumber
50be respectively 1.15mg/L and 1.32mg/L.The phonetic phenol of polyoxin and second is than when the 32:1 to 1:64, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 64 scopes, especially when the two proportioning is during at 8:1 to 1:8, synergistic effect is more obviously outstanding, wherein when polyoxin and the phonetic phenol weight ratio of second are 1 ︰ 12, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example three
Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are composite to wheat scab Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of 2-cyano-3-amino-3-phenylancryic acetate and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 polyoxin, 2-cyano-3-amino-3-phenylancryic acetate and the composite toxicity test analysis of results table to wheat scab thereof
As shown in Table 2, polyoxin, the EC of 2-cyano-3-amino-3-phenylancryic acetate to wheat scab
50be respectively 1.36mg/L and 1.92mg/L.Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate proportioning are when 32:1 to 1:64, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 64 scopes, especially when the two proportioning is during at 8:1 to 1:8, synergistic effect is more obviously outstanding, wherein when polyoxin and 2-cyano-3-amino-3-phenylancryic acetate weight ratio are 1 ︰ 2, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example four
Polyoxin and bromothalonil compounded are to apple mildew Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of bromothalonil and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 polyoxin, bromothalonil and the composite toxicity test analysis of results table to apple mildew thereof
As shown in Table 3, polyoxin, the EC of bromothalonil to apple mildew
50be respectively 1.25mg/L and 2.36mg/L.Polyoxin and bromothalonil proportioning are when 32:1 to 1:64, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and bromothalonil are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 64 scopes, especially when the two proportioning is during at 2:1 to 1:16, synergistic effect is more obviously outstanding, wherein when polyoxin and bromothalonil weight ratio are 1 ︰ 4, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example five
Polyoxin and zineb are composite to tomato blight Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of zineb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 polyoxin, zineb and the composite toxicity test analysis of results table to leaf spot of peanut thereof
As shown in Table 4, polyoxin, the EC of zineb to tomato blight
50be respectively 1.16mg/L and 23.28mg/L.Polyoxin and zineb proportioning are when 32:1 to 1:128, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and zineb are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 128 scopes, especially when the two proportioning is during at 1:1 to 1:16, synergistic effect is more obviously outstanding, wherein when polyoxin and zineb weight ratio are 1 ︰ 8, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example six:
Polyoxin and chlorothalonil compound are to downy mildew of garpe Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of tpn and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 5 polyoxin, tpn and the composite toxicity test analysis of results table to downy mildew of garpe thereof
As shown in Table 5, polyoxin, the EC of tpn to downy mildew of garpe
50be respectively 1.28mg/L and 29.64mg/L.Polyoxin and tpn are than when the 32:1 to 1:128, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and tpn are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 128 scopes, especially when the two proportioning is during at 1:1 to 1:16, synergistic effect is more obviously outstanding, wherein when polyoxin and tpn weight ratio are 1 ︰ 8, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example seven:
Polyoxin and dithianon are composite to capsicum epidemic disease Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining polyoxin, the former medicine of dithianon and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 6 polyoxin, tpn and the composite toxicity test analysis of results table to capsicum epidemic disease thereof
As shown in Table 6, polyoxin, the EC of dithianon to capsicum epidemic disease
50be respectively 1.13mg/L and 1.26mg/L.Polyoxin and dithianon are than when the 32:1 to 1:128, synergy ratio SR is all greater than 1.5, illustrate that polyoxin and dithianon are mixed and all show synergistic effect in 32 ︰ 1 to 1 ︰ 128 scopes, especially when the two proportioning is during at 8:1 to 1:8, synergistic effect is more obviously outstanding, wherein when polyoxin and dithianon weight ratio are 1 ︰ 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Application Example eight
Polyoxin and 2-cyano-3-amino-3-phenylancryic acetate and the composite wheat scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Yongshou County, Xianyang, Shanxi province city, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 25% 2-cyano-3-amino-3-phenylancryic acetate suspending agent (commercial).
Investigation wheat scab disease index before medicine, in their early stage dispenser, dispenser for the second time after 7 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the third time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 6 polyoxin, 2-cyano-3-amino-3-phenylancryic acetate and the composite wheat scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 6, after polyoxin and 2-cyano-3-amino-3-phenylancryic acetate are composite, can effectively prevent and treat wheat scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example nine polyoxins and bromothalonil and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment is in suburb, Zibo City, Shandong Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 25% bromothalonil wetting powder (commercial).
The investigation cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 7 polyoxin, bromothalonil and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 7, after polyoxin and bromothalonil compounded, can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example ten polyoxins and zineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Hu County, Xi'an City, Shanxi Province, and test medicine is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 80% Zineb wettable powder (commercial).
The investigation downy mildew of garpe state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 8 polyoxin, zineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, after polyoxin and zineb are composite, can effectively prevent and treat downy mildew of garpe, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 11 polyoxins and tpn and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 75% tpn wetting powder (commercial).
Investigation rice blast disease index before medicine, in their early stage dispenser, dispenser for the second time after 7 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 9 polyoxin, tpn and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 9, after polyoxin and chlorothalonil compound, can effectively prevent and treat the preventive effect that rice blast control efficiency is all better than single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 12 polyoxins and the phonetic phenol of second and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Hua County, Henan Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), the 25% phonetic phenol suspending agent of second (commercial).
Investigation powdery mildew of cucumber disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 10 polyoxin, the phonetic phenol of second and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 10, after the phonetic phenol of polyoxin and second is composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 13 polyoxins and dithianon and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
This experimental establishment is in region of Quzhou County, Hebei Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 22.7% dithianon suspending agent (commercial).
Investigation capsicum epidemic disease disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 10 polyoxin, dithianon and the composite control capsicum epidemic disease test of pesticide effectiveness thereof
As can be seen from Table 10, after polyoxin and dithianon are composite, can effectively prevent and treat capsicum epidemic disease, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (5)
1. a bactericidal composition that contains polyoxin, comprises effective active component, auxiliary agent and filler, it is characterized in that: effective active composition is A and B, and A, B percentage by weight are 32 ︰ 1 to 1 ︰ 64, and described A is polyoxin, and B is the phonetic phenol of second.
2. the bactericidal composition that contains polyoxin according to claim 1, is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 8 ︰ 1 to 1 ︰ 32.
3. contain according to claim 2 the bactericidal composition of polyoxin, it is characterized in that: the percentage by weight of polyoxin and the phonetic phenol of second is 8 ︰ 1 to 1 ︰ 8.
4. contain according to claim 1 the bactericidal composition of polyoxin, it is characterized in that: wherein effective active composition accounts for 5%～80% of gross weight.
5. the bactericidal composition that contains polyoxin according to claim 1 is for preventing and treating the application of crop downy mildew, epidemic disease, anthracnose, powdery mildew, leaf spot, head blight, rice blast.
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| CN104186507A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Biological compound microbicide for preventing and controlling wheat head scab and application of composition |
| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
| CN110583669A (en) * | 2019-10-28 | 2019-12-20 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN113907085A (en) * | 2021-11-16 | 2022-01-11 | 陕西麦可罗生物科技有限公司 | Bactericidal composition containing polyoxin and bromothalonil and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104186507A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Biological compound microbicide for preventing and controlling wheat head scab and application of composition |
| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
| CN110583669A (en) * | 2019-10-28 | 2019-12-20 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN110583669B (en) * | 2019-10-28 | 2022-03-15 | 安徽江淮园艺种业股份有限公司 | Bactericidal composition for melon diseases |
| CN113907085A (en) * | 2021-11-16 | 2022-01-11 | 陕西麦可罗生物科技有限公司 | Bactericidal composition containing polyoxin and bromothalonil and application thereof |
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