CN102017955B - Bactericidal composite containing metconazole and methoxy acrylate compounds - Google Patents
Bactericidal composite containing metconazole and methoxy acrylate compounds Download PDFInfo
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- CN102017955B CN102017955B CN201010607195.8A CN201010607195A CN102017955B CN 102017955 B CN102017955 B CN 102017955B CN 201010607195 A CN201010607195 A CN 201010607195A CN 102017955 B CN102017955 B CN 102017955B
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Abstract
The invention discloses a bactericidal composite containing metconazole and methoxy acrylate compounds, which comprises A and B, wherein A is metconazole, and B is selected from any one of the following bactericides: azoxystrobin, ethofenprox, benzol ethofenprox, pyrazol ethofenprox, and olefinic trifloxystrobin, and weigh part ratio of A to B is 1-80:180. The bactericidal composite can be used for controlling various diseases, has obvious synergy, widens bactericidal spectrum and has higher activity to downy mildew, epidemic disease, anthracnose, powdery mildew, alternaria leaf spot, leaf spot, cladosporium cucumerinum, rice blast and other diseases, can reduce the dosage of pesticides and residual amount of pesticides on crops and lower environment pollution.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains metconazole and methoxy acrylic ester compounds.
Background technology
Metconazole (Metconazole), for Japanese Wu Yu chemical company is in the trendy triazole bactericidal agent of early 1990s exploitation, molecular formula: C
17h
22clN
3o, structural formula:
Metconazole is C-14 demethylation enzyme inhibitor in ergosterol biosynthesis.Although the mechanism of action is the same with other triazole bactericidal agents, activity profile difference is larger.Two kinds of isomer have bactericidal activity, but cis activity is higher than trans.The antifungal spectrum of metconazole is very extensive, and active splendid.Metconazole field is used and cereal septoria musiva, fusarium and handle rest fungus are planted to disease is had remarkable effect.Metconazole is compared with traditional biocide agent, and dosage is extremely low and prevent and treat cereal to plant disease scope very wide.
But in the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the drug-fast generation of germ.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance germ.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really have a synergistic effect composite seldom, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, find metconazole and kresoxim-methyl, ZJ0712, pyraclostrobin and Enestroburin can produce good synergistic effect after composite, and not yet open about metconazole and the composite relevant report of methoxy acrylic ester compounds Fluoxastrobin, kresoxim-methyl, ZJ0712, pyraclostrobin and Enestroburin.
Summary of the invention
A kind of bactericidal composition that contains metconazole and methoxy acrylic ester compounds, comprise effective active component, auxiliary agent and filler, it is characterized in that: A, B percentage by weight are 1～80: 1～80, active component A is selected from metconazole, and active component B is Fluoxastrobin, kresoxim-methyl, ZJ0712, pyraclostrobin, Enestroburin.
Described a kind of bactericidal composition that contains metconazole and methoxy acrylic ester compounds, is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 5～65: 5～65.
The described bactericidal composition containing metconazole, is characterized in that: the percentage by weight of metconazole and Fluoxastrobin is 5～50: 5～50.
The described bactericidal composition containing metconazole, is characterized in that: the percentage by weight of metconazole and kresoxim-methyl is 5～50: 5～50.
The described bactericidal composition containing metconazole, is characterized in that: the percentage by weight of metconazole and ZJ0712 is 5～50: 5～50.
The described bactericidal composition containing metconazole, is characterized in that: the percentage by weight of metconazole and pyraclostrobin is 5～50: 5～50.
The described bactericidal composition containing metconazole, is characterized in that: the percentage by weight of metconazole and Enestroburin is 5～50: 5～50.
The ratio of weight and number of A, two kinds of active components of B is 1～80: 1～80.Conventionally in composition, active weight percentage is gross weight 0.5～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1～70% active substance by weight, is preferably 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, binding agent or defoamer.According to different dosage form, in preparation, can also contain disintegrant known in those skilled in the art, antifreeze etc.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described emulsifier is selected from: agriculture breast 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400# (benzyl dimethyl phenol polyoxy ethyl ether), agriculture breast 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), agriculture breast 36# (phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), agriculture breast 33# (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Described stabilizing agent is selected from one or more in sodium sorbate, butyl glycidyl ether, phenyl glycidyl ether, cresyl glycidyl ether, polyethylene glycol diglycidyl ether;
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer etc. by active substance with liquid flux or solid carrier.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent or suspension emulsion.
When making wetting powder, composition comprises following constituent content: metconazole 2～78%, active component B 2～78%, dispersant 5～10%, wetting agent 2～10%, filler 8～89%.
Active component metconazole, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: active component metconazole 2～78%, active component B 2～78%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
Active component metconazole, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make the water dispersible granules product of the present composition.
When making suspending agent, composition comprises following constituent content: active component metconazole 1～30%, active component B 1～30%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, binding agent 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add active component metconazole, active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make the suspending agent product of the present composition.
When making suspension emulsion, composition comprises following constituent content: metconazole 1～30%, effective active composition B 1～30%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of metconazole, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make metconazole suspending agent, then by the former medicine of effective active composition B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make the suspension emulsion product of the present composition.
The invention has the advantages that: after (1) metconazole and active component B are composite, there is notable synergistic and lasting effect; (2) expanded fungicidal spectrum, the diseases such as downy mildew, epidemic disease, anthracnose, powdery mildew, spot defoliation, leaf spot, scab, rice blast have all been had to greater activity; (3) the present invention not with an organic solvent, is difficult for producing poisoning, is convenient to transportation and storage; (4) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Example 160% metconazole kresoxim-methyl wetting powder
Metconazole 10%, kresoxim-methyl 50%, polyoxyethylene carboxylate 8%, Nekal BX 5%, bentonite add to 100%, and mixture carries out air-flow crushing, make 60% metconazole kresoxim-methyl wetting powder.
Example 280% metconazole kresoxim-methyl wetting powder
Metconazole 40%, kresoxim-methyl 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, lauryl sodium sulfate 4%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 80% metconazole kresoxim-methyl wetting powder.
Example 355% metconazole water dispersion granules agent of Kresoxim
Metconazole 5%, kresoxim-methyl 50%, soapberry powder 6%, alkyl benzene sulfonate calcium salt 7%, ammonium sulfate 1%, kaolin add to 100%, mix and make 55% metconazole water dispersion granules agent of Kresoxim.
Example 470% metconazole water dispersion granules agent of Kresoxim
Metconazole 60%, kresoxim-methyl 10%, wetting and penetrating agent F 4%, lignosulfonates 5%, urea 1.8%, bentonite add to 100%, mix and make 70% metconazole water dispersion granules agent of Kresoxim.
Example 520% metconazole kresoxim-methyl suspending agent
Metconazole 10%, kresoxim-methyl 10%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 4%, C
8～10aliphatic alcohols 0.4%, xanthans 0.8%, propane diols 2%, deionized water add to 100%, mix and make 20% metconazole kresoxim-methyl suspending agent.
Example 648% metconazole kresoxim-methyl suspending agent
Metconazole 8%, kresoxim-methyl 40%, alkylnaphthalene sulfonate 6%, soapberry powder 5%, silicone 0.2%, polyvinyl alcohol 1%, glycerine 3%, deionized water add to 100%, mix and make 48% metconazole kresoxim-methyl suspending agent.
Example 720% metconazole kresoxim-methyl suspension emulsion
Metconazole 5%, kresoxim-methyl 15%, phenyl phenol polyoxy ethyl ether phosphate 8%, alkyl benzene sulfonate calcium salt 7%, silkworm excrement 4%, C
8～10aliphatic alcohols 0.4%, xanthans 0.8%, propane diols 2%, deionized water add to 100%, mix and make 20% metconazole kresoxim-methyl suspension emulsion.
Example 848% metconazole kresoxim-methyl suspension emulsion
Metconazole 8%, kresoxim-methyl 40%, polyoxyethylene nonylphenol ether) 6%, alkylnaphthalene sulfonate 6%, soapberry powder 5%, silicone 0.2%, polyvinyl alcohol 1%, glycerine 3%, deionized water add to 100%, mix and make 48% metconazole kresoxim-methyl suspension emulsion.
Example 950% metconazole ZJ0712 wetting powder
Metconazole 40%, ZJ0712 10%, lignosulfonates 10%, wetting and penetrating agent F5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 50% metconazole ZJ0712 wetting powder.
Example 1080% metconazole ZJ0712 wetting powder
Metconazole 78%, ZJ0712 2%, alkyl benzene sulfonate calcium salt 6%, spaonin powder 4%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% metconazole ZJ0712 wetting powder.
Example 1140% metconazole ZJ0712 water dispersible granules
Metconazole 10%, ZJ0712 30%, alkylphenol-polyethenoxy are phonetic 7%, lauryl sodium sulfate 5%, aluminium chloride 0.3%, starch 15%, diatomite add to 100%, mix and make 40% metconazole ZJ0712 water dispersible granules.
Example 1265% metconazole ZJ0712 water dispersible granules
Metconazole 50%, ZJ0712 15%, polyoxyethylene carboxylate 8%, silkworm excrement 5%, urea 0.4%, bentonite add to 100%, mix and make 65% metconazole ZJ0712 water dispersible granules.
Example 1330% metconazole ZJ0712 suspending agent
Metconazole 15%, ZJ0712 15%, polycarboxylate 6%, wetting and penetrating agent F 4%, silicone oil 0.6%, gum Arabic 0.8%, ethylene glycol 2%, deionized water add to 100%, mix and make 30% metconazole ZJ0712 suspending agent.
Example 1440% metconazole ZJ0712 suspending agent
Metconazole 32%, ZJ0712 8%, alkyl benzene sulfonate calcium salt 8%, soapberry powder 5%, C
10～20saturated fat acids 1.2%, polyvinylpyrrolidone 1.5%, propane diols 3%, deionized water add to 100%, mix and make 40% metconazole ZJ0712 suspending agent.
Example 1530% metconazole ZJ0712 suspension emulsion
Metconazole 10%, ZJ0712 20%, castor oil polyoxyethylene ether 7%, polycarboxylate 6%, wetting and penetrating agent F 4%, silicone oil 0.6%, gum Arabic 0.8%, ethylene glycol 2%, deionized water add to 100%, mix and make 30% metconazole ZJ0712 suspension emulsion.
Example 1640% metconazole ZJ0712 suspension emulsion
Metconazole 30%, ZJ0712 10%, fat alcohol alcohol APEO 6%, alkyl benzene sulfonate calcium salt 8%, soapberry powder 5%, C
10～20saturated fat acids 1.2%, polyvinylpyrrolidone 1.5%, propane diols 3%, deionized water add to 100%, mix and make 40% metconazole ZJ0712 suspension emulsion.
Example 1760% metconazole pyraclostrobin wetting powder
Metconazole 50%, pyraclostrobin 10%, aryl phenol polyoxyethylene succinate sulfonate 8%, wetting and penetrating agent F 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 60% metconazole pyraclostrobin wetting powder.
Example 1880% metconazole pyraclostrobin wetting powder
Metconazole 2%, pyraclostrobin 78%, lignosulfonates 7%, spaonin powder 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% metconazole pyraclostrobin wetting powder.
Example 1950% metconazole pyraclostrobin water dispersible granules
Metconazole 10%, pyraclostrobin 40%, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, mix and make 50% metconazole pyraclostrobin water dispersible granules.
Example 2065% metconazole pyraclostrobin water dispersible granules
Metconazole 15%, pyraclostrobin 50%, lignosulfonates 7%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 65% metconazole pyraclostrobin water dispersible granules.
Example 2132% metconazole pyraclostrobin suspending agent
Metconazole 24%, pyraclostrobin 8%, the phonetic formaldehyde condensation products sulphate 10% of alkylphenol-polyethenoxy, lauryl sodium sulfate 4%, silicone oil 0.2%, sodium phosphate trimer 1%, polyethylene glycol 2%, deionized water add to 100%, mix and make 32% metconazole pyraclostrobin suspending agent.
Example 2242% metconazole pyraclostrobin suspending agent
Metconazole 20%, pyraclostrobin 22%, polyoxyethylene carboxylate 6%, wetting and penetrating agent F 6%, silicone compound 1.2%, crospolyvinylpyrrolidone 0.6%, propane diols 2%, deionized water add to 100%, mix and make 42% metconazole pyraclostrobin suspending agent.
Example 2332% metconazole pyraclostrobin suspension emulsion
Metconazole 8%, pyraclostrobin 24%, the phonetic formaldehyde condensation products sulphate 10% of alkylphenol-polyethenoxy, castor oil polyoxyethylene ether 5%, lauryl sodium sulfate 4%, silicone oil 0.2%, sodium phosphate trimer 1%, polyethylene glycol 2%, deionized water add to 100%, mix and make 32% metconazole pyraclostrobin suspension emulsion.
Example 2445% metconazole pyraclostrobin suspension emulsion
Metconazole 5%, pyraclostrobin 40%, sorbitan monostearate 4%, polyoxyethylene carboxylate 6%, wetting and penetrating agent F 6%, silicone compound 1.2%, crospolyvinylpyrrolidone 0.6%, propane diols 2%, deionized water add to 100%, mix and make 45% metconazole pyraclostrobin suspension emulsion.
Example 2545% metconazole Enestroburin wetting powder
Metconazole 15%, Enestroburin 30%, alkyl benzene sulfonate calcium salt 9%, silkworm excrement 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 45% metconazole Enestroburin wetting powder.
Example 2680% metconazole Enestroburin wetting powder
Metconazole 60%, Enestroburin 20%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, soapberry powder 6%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% metconazole Enestroburin wetting powder.
Example 2736% metconazole Enestroburin water dispersible granules
Metconazole 24%, Enestroburin 12%, lignosulfonates 6%, wetting and penetrating agent F5%, ammonium sulfate 1.2%, bentonite add to 100%, mix and make 36% metconazole Enestroburin water dispersible granules.
Example 2842% metconazole Enestroburin water dispersible granules
Metconazole 32%, Enestroburin 10%, alkylnaphthalene sulfonate 8%, spaonin powder 4%, ammonium sulfate 1%, bentonite add to 100%, mix and make 42% metconazole Enestroburin water dispersible granules.
Example 2916% metconazole Enestroburin suspending agent
Metconazole 8%, Enestroburin 8%, polycarboxylate 8%, Nekal BX 6%, silicone compound 0.7%, xanthans 0.6%, propane diols 1%, deionized water add to 100%, mix and make 16% metconazole Enestroburin suspending agent.
Example 3042% metconazole Enestroburin suspending agent
Metconazole 35%, Enestroburin 7%, lignosulfonates 7%, soapberry powder 6, silicone oil 0.2%, polyvinyl alcohol 1%, ethylene glycol 1%, deionized water add to 100%, mix and make 42% metconazole Enestroburin suspending agent.
Example 3110% metconazole Enestroburin suspension emulsion
Metconazole 5%, Enestroburin 5%, polycarboxylate 6%, lauryl sodium sulfate 3%, spaonin powder 4%, polyvinylpyrrolidone 0.5%, glycerine 2%, silicone compound 0.3%, tween series 4%, water add to 100%, mix and make 10% metconazole Enestroburin suspension emulsion.
Example 3236% metconazole Enestroburin suspension emulsion
Metconazole 10%, Enestroburin 26%, aryl phenol polyoxyethylene succinate sulfonate 6%, lauryl sodium sulfate 3%, silkworm excrement 2%, sodium phosphate trimer 1.2%, ethylene glycol 0.8%, C
8～10aliphatic alcohols 1%, agriculture breast 34#3%, water add to 100%, mix and make 36% metconazole Enestroburin suspension emulsion.
Example 3360% metconazole Fluoxastrobin wetting powder
Metconazole 10%, Fluoxastrobin 50%, aryl phenol polyoxyethylene succinate sulfonate 8%, wetting and penetrating agent F 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 60% metconazole Fluoxastrobin wetting powder.
Example 3480% metconazole Fluoxastrobin wetting powder
Metconazole 2%, Fluoxastrobin 78%, lignosulfonates 7%, spaonin powder 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% metconazole Fluoxastrobin wetting powder.
Example 3550% metconazole azoxystrobin water dispersible granule
Metconazole 10%, Fluoxastrobin 40%, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 4%, aluminium chloride 0.8%, bentonite add to 100%, mix and make 50% metconazole azoxystrobin water dispersible granule.
Example 3665% metconazole azoxystrobin water dispersible granule
Metconazole 15%, Fluoxastrobin 50%, lignosulfonates 7%, Nekal BX 5%, ammonium sulfate 1%, bentonite add to 100%, mix and make 65% metconazole azoxystrobin water dispersible granule.
Example 3732% metconazole Fluoxastrobin suspending agent
Metconazole 24%, Fluoxastrobin 8%, the phonetic formaldehyde condensation products sulphate 10% of alkylphenol-polyethenoxy, lauryl sodium sulfate 4%, silicone oil 0.2%, sodium phosphate trimer 1%, polyethylene glycol 2%, deionized water add to 100%, mix and make 32% metconazole Fluoxastrobin suspending agent.
Example 3840% metconazole Fluoxastrobin suspending agent
Metconazole 20%, Fluoxastrobin 20%, polyoxyethylene carboxylate 6%, wetting and penetrating agent F 6%, silicone compound 1.2%, crospolyvinylpyrrolidone 0.6%, propane diols 2%, deionized water add to 100%, mix and make 40% metconazole Fluoxastrobin suspending agent.
Example 3910% metconazole Fluoxastrobin suspension emulsion
Metconazole 5%, Fluoxastrobin 5%, polycarboxylate 6%, lauryl sodium sulfate 3%, spaonin powder 4%, polyvinylpyrrolidone 0.5%, glycerine 2%, silicone compound 0.3%, tween series 4%, water add to 100%, mix and make 10% metconazole Fluoxastrobin suspension emulsion.
Example 4036% metconazole Fluoxastrobin suspension emulsion
Metconazole 10%, Fluoxastrobin 26%, aryl phenol polyoxyethylene succinate sulfonate 6%, lauryl sodium sulfate 3%, silkworm excrement 2%, sodium phosphate trimer 1.5%, ethylene glycol 0.5%, C
8～10aliphatic alcohols 1%, agriculture breast 34#3%, water add to 100%, mix and make 36% metconazole Fluoxastrobin suspension emulsion.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
The composite Toxicity Determination to target of metconazole and active component B (B is selected from the one of Fluoxastrobin, kresoxim-methyl, ZJ0712, pyraclostrobin, Enestroburin).
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to target fungus.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component metconazole and B (Fluoxastrobin, kresoxim-methyl, ZJ0712, pyraclostrobin, Enestroburin) shared ratio in combination;
A is metconazole;
B is the one in Fluoxastrobin, kresoxim-methyl, ZJ0712, pyraclostrobin, Enestroburin.
Implementation of an application example two metconazoles and kresoxim-methyl are composite to alternaria leaf spot of apple Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining metconazole, the former medicine of kresoxim-methyl and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 metconazole, kresoxim-methyl and the composite toxicity test analysis of results table to alternaria leaf spot of apple thereof
As shown in Table 1, metconazole, the EC of kresoxim-methyl to alternaria leaf spot of apple
50be respectively 2.94mg/L and 2.53mg/L.The virulence of kresoxim-methyl is higher than the virulence of metconazole.Metconazole and kresoxim-methyl proportioning were at 40: 1 to 1: 40 o'clock, synergy ratio SR is all greater than 1.5, illustrate that metconazole and kresoxim-methyl mixture in 40: 1 to 1: 40 scopes all shows synergistic effect, especially when the two proportioning is during at 10: 1 to 1: 10, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that metconazole and kresoxim-methyl weight ratio are 1: 1, synergistic effect is the most obvious.
Implementation of an application example three metconazoles and ZJ0712 are composite to powdery mildew of cucumber Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining metconazole, the former medicine of ZJ0712 and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 metconazole, ZJ0712 and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 2, metconazole, the EC of ZJ0712 to powdery mildew of cucumber
50be respectively 3.21mg/L and 0.87mg/L.The virulence of ZJ0712 is higher than the virulence of metconazole.Metconazole and ZJ0712 proportioning were at 40: 1 to 1: 40 o'clock, synergy ratio SR is all greater than 1.5, illustrate that metconazole and ZJ0712 mixture in 40: 1 to 1: 40 scopes all shows synergistic effect, especially when the two proportioning is during at 12: 1 to 1: 4, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that metconazole and ZJ0712 weight ratio are 4: 1, synergistic effect is the most obvious.
Implementation of an application example four
Metconazole and pyraclostrobin are composite to sigatoka Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining metconazole, the former medicine of pyraclostrobin and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 metconazole, pyraclostrobin and the composite toxicity test analysis of results table to sigatoka thereof
As shown in Table 3, metconazole, the EC of pyraclostrobin to sigatoka
50be respectively 2.86mg/L and 2.59mg/L.The virulence of pyraclostrobin is higher than the virulence of metconazole.Metconazole and pyraclostrobin proportioning were at 40: 1 to 1: 40 o'clock, synergy ratio SR is all greater than 1.5, illustrate that metconazole and pyraclostrobin mixture in 40: 1 to 1: 40 scopes all shows synergistic effect, especially when the two proportioning is during at 9: 1 to 1: 9, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that metconazole and pyraclostrobin weight ratio are 1: 1, synergistic effect is the most obvious.
Implementation of an application example five:
Metconazole and Enestroburin are composite to downy mildew of garpe Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining metconazole, the former medicine of Enestroburin and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 metconazole, Enestroburin and the composite toxicity test analysis of results table to downy mildew of garpe thereof
As shown in Table 4, metconazole, the EC of Enestroburin to downy mildew of garpe
50be respectively 2.85mg/L and 2.67mg/L.The virulence of Enestroburin is higher than the virulence of metconazole.Metconazole compares at 40: 1 to 1: 40 o'clock with Enestroburin, synergy ratio SR is all greater than 1.5, illustrate that metconazole and Enestroburin mixture in 10: 1 to 1: 10 scopes all shows synergistic effect, wherein synergy ratio SR maximum in the time that metconazole and Enestroburin weight ratio are 1: 1, synergistic effect is the most obvious.
Implementation of an application example six:
Metconazole and azoxystrobin compound are to graw mold of tomato Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining metconazole, the former medicine of Fluoxastrobin and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 5 metconazole, Fluoxastrobin and the composite toxicity test analysis of results table to graw mold of tomato thereof
As shown in Table 5, metconazole, the EC of Fluoxastrobin to graw mold of tomato
50be respectively 2.34mg/L and 2.65mg/L.The virulence of Fluoxastrobin is higher than the virulence of metconazole.Metconazole compares at 40: 1 to 1: 40 o'clock with Fluoxastrobin, synergy ratio SR is all greater than 1.5, illustrate that metconazole and Fluoxastrobin mixture in 10: 1 to 1: 10 scopes all shows synergistic effect, wherein synergy ratio SR maximum in the time that metconazole and Fluoxastrobin weight ratio are 1: 1, synergistic effect is the most obvious.
Application Example seven metconazoles and kresoxim-methyl and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Dali County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 60g/L metconazole aqueous emulsion (commercial), 50% water dispersion granules agent of Kresoxim (commercial).
Investigation alternaria leaf spot of apple disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 3 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 6 metconazole, kresoxim-methyl and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 6, after metconazole and kresoxim-methyl are composite, can effectively prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example eight metconazoles and ZJ0712 and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in suburb, Rizhao City, Shandong Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 60g/L metconazole aqueous emulsion (commercial), 10% ZJ0712 suspending agent (commercial).
The investigation powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 7 metconazole, ZJ0712 and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 7, after metconazole and ZJ0712 are composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example nine metconazoles and pyraclostrobin and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Longan County, Guangxi province Nanning City, and test medicine is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 60g/L metconazole aqueous emulsion (commercial), 250 grams per liter pyraclostrobin missible oil (commercial).
The investigation sigatoka state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 8 metconazole, pyraclostrobin and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, after metconazole and pyraclostrobin are composite, can effectively prevent and treat sigatoka, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example ten metconazoles and Enestroburin and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan city Linwei district, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 60g/L metconazole aqueous emulsion (commercial), 25% Enestroburin missible oil (commercial).
Investigation downy mildew of garpe disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 9 metconazole, Enestroburin and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 9, after metconazole and Enestroburin are composite, can effectively prevent and treat downy mildew of garpe, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 11 metconazoles and Fluoxastrobin and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Gaotai County, Zhangye City, Gansu Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 60g/L metconazole aqueous emulsion (commercial), 50% azoxystrobin water dispersible granule (commercial).
Investigation early blight of tomato disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 10 metconazole, Fluoxastrobin and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 10, after metconazole and azoxystrobin compound, can effectively prevent and treat early blight of tomato, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (5)
1. containing a bactericidal composition for metconazole and methoxy acrylic, by effective active composition, auxiliary agent and media assemblage, it is characterized in that: the weight ratio of effective active composition metconazole and ZJ0712 is 1:40 ~ 40:1.
2. the bactericidal composition containing metconazole and methoxy acrylic according to claim 1, is characterized in that: the weight ratio of metconazole and ZJ0712 is 1:20 ~ 20:1.
3. according to claim 2 containing the bactericidal composition of metconazole and methoxy acrylic, it is characterized in that: the weight ratio of metconazole and ZJ0712 is 1:4 ~ 12:1.
4. according to claim 1 containing the bactericidal composition of metconazole and methoxy acrylic, it is characterized in that: wherein effective active composition accounts for 5% ~ 85% of gross weight.
5. according to claim 1 containing the bactericidal composition of metconazole and methoxy acrylic, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
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| CN103168786B (en) * | 2013-03-15 | 2014-09-10 | 江苏七洲绿色化工股份有限公司 | Ternary compound bactericidal composition and application thereof |
| CN103583537A (en) * | 2013-10-23 | 2014-02-19 | 江苏丰登农药有限公司 | Sterilization composition containing metconazole and pyraclostrobin and application of sterilization composition |
| CN104186512A (en) * | 2014-09-22 | 2014-12-10 | 江苏省绿盾植保农药实验有限公司 | Sterilization composition and application thereof |
| CN104604927A (en) * | 2015-01-30 | 2015-05-13 | 北农（海利）涿州种衣剂有限公司 | Seed-treating agent containing clothianidin, pyraclostrobin and metconazole |
| CN104957159B (en) * | 2015-03-31 | 2017-04-05 | 河南科技学院 | A kind of bactericidal composition containing metconazole and chlorine nalidixic bacterium ester and application thereof |
| CN108064856A (en) * | 2016-11-11 | 2018-05-25 | 华中师范大学 | A kind of composition pesticide and its application containing benzothiostrobin and metconazole |
| GB2562082B (en) * | 2017-05-04 | 2021-10-27 | Rotam Agrochem Int Co Ltd | A fungicidal composition and the use thereof |
| CN107094768A (en) * | 2017-06-15 | 2017-08-29 | 江苏徐淮地区淮阴农业科学研究所 | A kind of collaboration decrement composition pesticide containing Enestroburin |
| CN108835116A (en) * | 2018-07-25 | 2018-11-20 | 安徽华星化工有限公司 | One kind microbicide compositions containing Yekuzuo and its application |
| CN114041473B (en) * | 2021-07-01 | 2023-05-05 | 上海赫腾精细化工有限公司 | Sterilization composition containing metconazole and pyraclostrobin and application thereof |
| CN113615699A (en) * | 2021-08-13 | 2021-11-09 | 韩农(黑龙江)化工有限公司 | Bactericidal composition containing metconazole and pyraclostrobin and preparation method and application thereof |
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| CN1864484A (en) * | 2005-05-18 | 2006-11-22 | 安徽华星化工股份有限公司 | Compound sterilization composition based on kresoxim methyl |
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| CN1864484A (en) * | 2005-05-18 | 2006-11-22 | 安徽华星化工股份有限公司 | Compound sterilization composition based on kresoxim methyl |
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