CN102057935B - Bactericidal composition containing imidazole - Google Patents
Bactericidal composition containing imidazole Download PDFInfo
- Publication number
- CN102057935B CN102057935B CN201110003155.7A CN201110003155A CN102057935B CN 102057935 B CN102057935 B CN 102057935B CN 201110003155 A CN201110003155 A CN 201110003155A CN 102057935 B CN102057935 B CN 102057935B
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- Prior art keywords
- glyoxalin
- imazalil
- prochloraz
- probenazole
- active component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition containing imidazole, which comprises an active component A and an active component B, wherein the active component A is imidazole, the active component B is selected from one of the following bactericides: carbendazim, thiophanate methyl, probenazole, prochloraz, imazalil and triflumizole, and the weight percentage of the active component A to the active component B is (1-40%): (1-80%). Adjuvant and excipient are added to the active components to prepare wettable powder, water dispersible granules, suspending agents or suspending emulsion. The bactericidal composition can be used for preventing and treating scab, ring spot, alternaria leaf spot, anthracnose, spot anthracnose, shot hole and powdery mildew. The bactericidal composition can resist rain wash, and has obvious synergistic effect.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition that contains glyoxalin in crop pest.
Technical background
Glyoxalin, English name: imibenconazole, molecular formula: C
17h
13c
l3n
4s, chemical name: 4-chlorobenzyl N-(2,4-dichlorophenyl)-2 (1H-1,2,4-triazol-1-yl) thioacetamide ester, structural formula:
Glyoxalin is broad spectrum activity triazole bactericidal agent.Main Function mechanism is to destroy and stop the biosynthesis of the after birth important composition composition ergosterol of threading of germ, thereby destroys the formation of cell membrane, causes germ death.Glyoxalin has protection and therapeutic action, can rapid osmotic after being sprayed onto on crop in plant corpus, resistance of rainwater washing against.
Glyoxalin single dose is used for a long time, easily makes disease develop immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, be to delay the disease conventional method that develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can expand fungicidal spectrum, improves germicidal efficiency.Glyoxalin is different from the effective active composition B mechanism of action, mutually composite have good synergistic effect within the specific limits, and relevant composite about glyoxalin and carbendazim, thiophanate-methyl, probenazole, Prochloraz, imazalil, fluorine bacterium azoles, there is not yet relevant report at present at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains glyoxalin and effective active composition B.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains glyoxalin, it is characterized in that: the percentage by weight of A, two kinds of active components of B is 1～40%: 1～80%, described A component is glyoxalin, and B component is selected from the one of carbendazim, thiophanate-methyl, probenazole, Prochloraz, imazalil, fluorine bacterium azoles.
The described glyoxalin bactericidal composition that contains, is characterized in that: wherein the percentage by weight of glyoxalin and effective active composition B is 1～35%: 5～70%.
The described bactericidal composition that contains glyoxalin and carbendazim, is characterized in that: wherein the percentage by weight of glyoxalin and carbendazim is 5～30%: 10～60%.
The described bactericidal composition that contains glyoxalin and thiophanate-methyl, is characterized in that: wherein the percentage by weight of glyoxalin and thiophanate-methyl is 5～30%: 10～60%.
The described bactericidal composition that contains glyoxalin and probenazole, is characterized in that: wherein the percentage by weight of glyoxalin and probenazole is 5～30%: 10～50%.
The described bactericidal composition that contains glyoxalin and Prochloraz, is characterized in that: wherein the percentage by weight of glyoxalin and Prochloraz is 5～30%: 10～50%.
The described bactericidal composition that contains glyoxalin and imazalil, is characterized in that: wherein the percentage by weight of glyoxalin and imazalil is 5～30%: 10～50%.
The described bactericidal composition that contains glyoxalin and fluorine bacterium azoles, is characterized in that: wherein the percentage by weight of glyoxalin and fluorine bacterium azoles is 5～30%: 5～40%.
The described bactericidal composition that contains glyoxalin, wherein effective active component content accounts for 1～95% of gross weight, is preferably 20～80%.
The described bactericidal composition that contains glyoxalin is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
When making wetting powder, composition comprises following constituent content: glyoxalin 1～40%, effective active composition B 1～80%, dispersant 3～10%, wetting agent 2～10%, filler 8～93%.
Glyoxalin, effective active composition B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: glyoxalin 1～40%, effective active composition B1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, filler 8～93%.
Glyoxalin, effective active composition B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make present composition water dispersible granules product.
When making suspending agent, composition comprises following constituent content: glyoxalin 1～20%, active ingredient B 1～40%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0～8%, stabilizing agent 0%～3%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, glyoxalin, add active ingredient B, ball milling 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes present composition suspending agent product.
When making suspension emulsion, composition comprises following constituent content: glyoxalin 1～20%, effective active composition B 1～40%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of glyoxalin, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make glyoxalin suspending agent, then by the former medicine of effective active composition B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make present composition suspension emulsion product.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described emulsifier is selected from: agriculture breast 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400# (benzyl dimethyl phenol polyoxy ethyl ether), agriculture breast 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), agriculture breast 36# (phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), agriculture breast 33# (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Described stabilizing agent is selected from: one or more in BHT, triphenyl phosphite, epoxychloropropane, tributyl phosphate, triethanolamine, diethanol amine, monoethanolamine.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Beneficial effect of the present invention: (1) present composition effective active composition glyoxalin and effective active composition B belong to the bactericide of two kinds of different mechanisms of action, and both mutual mixtures can not produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) the present invention not with an organic solvent, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has expanded fungicidal spectrum, and the diseases such as crop scab, ring spot, spot defoliation, anthracnose, anthrachose of grape, shot hole, powdery mildew are all had to special efficacy.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Application Example one
Example 1 66% glyoxalin carbendazol wettable powder
Glyoxalin 6%, carbendazim 60%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, silkworm excrement 7%, bentonite add to 100%, and mixture carries out air-flow crushing, makes 66% glyoxalin carbendazol wettable powder.
Example 2 80% glyoxalin carbendazol wettable powders
Glyoxalin 10%, carbendazim 70%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, Nekal BX 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% glyoxalin carbendazol wettable powder.
Example 3 50% glyoxalin carbendazim water dispersing granules
Glyoxalin 5%, carbendazim 45%, soapberry powder 4%, alkylphenol-polyethenoxy are phonetic 6%, urea 1.3%, diatomite add to 100%, mix and make 50% glyoxalin carbendazim water dispersing granule.
Example 4 60% glyoxalin carbendazim water dispersing granules
Glyoxalin 5%, carbendazim 55%, neopelex 6%, polycarboxylate 8%, bentonite add to 100%, mix and make 60% glyoxalin carbendazim water dispersing granule.
Example 5 12% glyoxalin carbendazim suspending agents
Glyoxalin 2%, carbendazim 10%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, spaonin powder 6%, C
8～10aliphatic alcohols 0.5%, polyvinylpyrrolidone 1.6%, propane diols 1.4%, deionized water add to 100%, mix and make 12% glyoxalin carbendazim suspending agent.
Example 6 48% glyoxalin carbendazim suspending agents
Glyoxalin 3%, carbendazim 45%, aliphatic amine polyoxyethylene are phonetic 6%, wetting and penetrating agent F5%, silicone oil 0.4%, gum Arabic 1.5%, ethylene glycol 1.7%, deionized water add to 100%, mix and make 48% glyoxalin carbendazim suspending agent.
Example 7 55% glyoxalin thiophanate-methyl wetting powders
Glyoxalin 5%, thiophanate-methyl 50%, naphthalene sulfonic acid-formaldehyde condensation product 6%, soapberry powder 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 55% glyoxalin thiophanate-methyl wetting powder.
Example 8 81% glyoxalin thiophanate-methyl wetting powders
Glyoxalin 1%, thiophanate-methyl 80%, polyoxyethylene carboxylate 6%, Nekal BX 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 81% glyoxalin thiophanate-methyl wetting powder.
Example 9 32% glyoxalin thiophanate-methyl water dispersible granules
Glyoxalin 2%, thiophanate-methyl 30%, octylphenol polyethylene oxyethylene group ether sulfate 7%, spaonin powder 5%, ammonium sulfate 1.2%, diatomite add to 100%, mix and make 32% glyoxalin thiophanate-methyl water dispersible granules.
Example 10 63% glyoxalin thiophanate-methyl water dispersible granules
Glyoxalin 3%, thiophanate-methyl 60%, lignosulfonates 8%, wetting and penetrating agent F6%, bentonite add to 100%, mix and make 63% glyoxalin thiophanate-methyl water dispersible granules.
Example 11 10% glyoxalin thiophanate-methyl suspending agents
Glyoxalin 5%, thiophanate-methyl 5%, polyoxyethylene carboxylate 7%, neopelex 5%, C
10～20saturated fat acids 0.2%, polyvinylpyrrolidone 1.4%, polyethylene glycol 1.8%, deionized water add to 100%, mix and make 10% glyoxalin thiophanate-methyl suspending agent.
Example 12 42% glyoxalin thiophanate-methyl suspending agents
Glyoxalin 7%, thiophanate-methyl 35%, aryl phenol polyoxyethylene succinate sulfonate 5%, Nekal BX 5%, silicone compound 0.5%, methylcellulose 1.2%, glycerine 1.4%, deionized water add to 100%, mix and make 42% glyoxalin thiophanate-methyl suspending agent.
Example 13 50% glyoxalin probenazole wetting powders
Glyoxalin 10%, probenazole 40%, alkyl benzene sulfonate calcium salt 7%, wetting and penetrating agent F 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 50% glyoxalin probenazole wetting powder.
Example 14 75% glyoxalin probenazole wetting powders
Glyoxalin 15%, probenazole 60%, lignosulfonates 7%, soapberry powder 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 75% glyoxalin probenazole wetting powder.
Example 15 56% glyoxalin probenazole water dispersible granules
Glyoxalin 6%, probenazole 50%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, silkworm excrement 6%, bentonite add to 100%, mix and make 56% glyoxalin probenazole water dispersible granules.
Example 16 72% glyoxalin probenazole water dispersible granules
Glyoxalin 8%, probenazole 64%, polycarboxylate 6%, neopelex 5%, aluminium chloride 1.1%, kaolin add to 100%, mix and make 72% glyoxalin probenazole water dispersible granules.
Example 17 25% glyoxalin probenazole suspending agents
Glyoxalin 5%, probenazole 20%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 6%, C
10～20saturated fat acids 0.2%, xanthans 1.8%, ethylene glycol 1.7%, deionized water add to 100%, mix and make 25% glyoxalin probenazole suspending agent.
Example 18 36% glyoxalin probenazole suspending agents
Glyoxalin 4%, probenazole 32%, lignosulfonates 6%, wetting and penetrating agent F 5%, silicone oil 0.4%, sodium phosphate trimer 1.5%, glycerine 1.7%, deionized water add to 100%, mix and make 36% glyoxalin probenazole suspending agent.
Example 19 10% glyoxalin probenazole suspension emulsions
Glyoxalin 5%, probenazole 5%, polyoxyethylene carboxylate 7%, soapberry powder 5%, polyvinylpyrrolidone 1.5%, agriculture breast 400#7%, ethylene glycol 1.6%, silicone compound 0.3%, water add to 100%, make 10% glyoxalin probenazole suspension emulsion through mixing.
Example 20 36% glyoxalin probenazole suspension emulsions
Glyoxalin 12%, probenazole 24%, lignosulfonates 7%, Nekal BX 4%, xanthans 1.4%, agriculture breast 500#7%, polyethylene glycol 1.5%, C
8～10aliphatic alcohols 0.5%, water add to 100%, make 36% glyoxalin probenazole suspension emulsion through mixing.
Example 21 45% glyoxalin Prochloraz wetting powders
Glyoxalin 5%, Prochloraz 40%, aliphatic amine polyoxyethylene are phonetic 6%, wetting and penetrating agent F4%, kaolin add to 100%, and mixture carries out air-flow crushing, makes 45% glyoxalin Prochloraz wetting powder.
Example 22 76% glyoxalin Prochloraz wetting powders
Glyoxalin 6%, Prochloraz 70%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, silkworm excrement 6%, white carbon add to 100%, and mixture carries out air-flow crushing, make 76% glyoxalin Prochloraz wetting powder.
Example 23 50% glyoxalin Prochloraz water dispersible granules
Glyoxalin 10%, Prochloraz 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, lauryl sodium sulfate 6%, bentonite add to 100%, mix and make 50% glyoxalin Prochloraz water dispersible granules.
Example 24 75% glyoxalin Prochloraz water dispersible granules
Glyoxalin 15%, Prochloraz 60%, polyoxyethylene carboxylate 6%, Nekal BX F4%, urea 1.5%, diatomite add to 100%, mix and make 75% glyoxalin Prochloraz water dispersible granules.
Example 25 30% glyoxalin Prochloraz suspending agents
Glyoxalin 10%, Prochloraz 20%, alkyl benzene sulfonate calcium salt 8%, wetting and penetrating agent F 6%, C
8～10aliphatic alcohols 0.5%, xanthans 1.7%, ethylene glycol 1.5%, deionized water add to 100%, mix and make 30% glyoxalin Prochloraz suspending agent.
Example 26 35% glyoxalin Prochloraz suspending agents
Glyoxalin 7%, Prochloraz 28%, polyoxyethylene carboxylate 6%, spaonin powder 5%, silicone oil 0.4%, sodium phosphate trimer 1.2%, propane diols 1.6%, deionized water add to 100%, mix and make 35% glyoxalin Prochloraz suspending agent.
Example 27 12% glyoxalin Prochloraz suspension emulsions
Glyoxalin 6%, Prochloraz 6%, lignosulfonates 5%, soapberry powder 4%, C
10～20saturated fat acids 0.5%, methylcellulose 1.6%, agriculture breast 600#6%, ethylene glycol 1.8%, water add to 100%, and aforementioned formula material is mixed, and make 12% glyoxalin Prochloraz suspension emulsion.
Example 28 36% glyoxalin Prochloraz suspension emulsions
Glyoxalin 4%, Prochloraz 32%, octylphenol polyethylene oxyethylene group ether sulfate 8%, lauryl sodium sulfate 6%, C
8～10aliphatic alcohols 0.7%, xanthans 1.4%, agriculture breast 34#7%, glycerine 1.7%, water add to 100%, and aforementioned formula material is mixed, and make 36% glyoxalin Prochloraz suspension emulsion.
Example 29 60% glyoxalin imazalil wetting powders
Glyoxalin 12%, imazalil 48%, naphthalene sulfonic acid-formaldehyde condensation product 5%, spaonin powder 4%, kaolin add to 100%, and mixture carries out air-flow crushing, make 60% glyoxalin imazalil wetting powder.
Example 30 70% glyoxalin imazalil wetting powders
Glyoxalin 20%, imazalil 50%, ester polyoxyethylene are phonetic 7%, soapberry powder 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, makes 70% glyoxalin imazalil wetting powder.
Example 31 50% glyoxalin imazalil water dispersible granules
Glyoxalin 10%, imazalil 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, wetting and penetrating agent F 7%, bentonite add to 100%, mix and make 50% glyoxalin imazalil water dispersible granules.
Example 32 75% glyoxalin imazalil water dispersible granules
Glyoxalin 5%, imazalil 70%, alkyl benzene sulfonate calcium salt 6%, neopelex 4%, aluminium chloride 1.2%, kaolin add to 100%, mix and make 75% glyoxalin imazalil water dispersible granules.
Example 33 16% glyoxalin imazalil suspending agents
Glyoxalin 8%, imazalil 8%, alkyl benzene sulfonate calcium salt 7%, spaonin powder 5%, C
10～20saturated fat acids 0.6%, gum Arabic 1.2%, ethylene glycol 1.6%, deionized water add to 100%, mix and make 16% glyoxalin imazalil suspending agent.
Example 34 35% glyoxalin imazalil suspending agents
Glyoxalin 10%, imazalil 25%, octylphenol polyethylene oxyethylene group ether sulfate 8%, wetting and penetrating agent F 6%, silicone oil 0.4%, polyvinyl alcohol 1.5%, glycerine 1.4%, deionized water add to 100%, mix and make 35% glyoxalin imazalil suspending agent.
Example 35 15% glyoxalin imazalil suspension emulsions
Glyoxalin 5%, imazalil 10%, aliphatic amine polyoxyethylene are phonetic 6%, Nekal BX 5%, silicone compound 0.2%, sodium phosphate trimer 1.6%, tween series 5%, propane diols 1.7%, water add to 100%, aforementioned formula material is mixed, make 15% glyoxalin imazalil suspension emulsion.
Example 36 45% glyoxalin imazalil suspension emulsions
Glyoxalin 5%, imazalil 40%, lignosulfonates 5%, spaonin powder 4%, C
10～20saturated fat acids 0.3%, polyvinylpyrrolidone 1.3%, OP series phosphate 6%, polyethylene glycol 1.6%, water add to 100%, and aforementioned formula material is mixed, and make 45% glyoxalin imazalil suspension emulsion.
Example 37 42% glyoxalin triflumizole wettable powders
Glyoxalin 20%, fluorine bacterium azoles 22%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, silkworm excrement 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, makes 42% glyoxalin triflumizole wettable powder.
Example 38 45% glyoxalin triflumizole wettable powders
Glyoxalin 15%, fluorine bacterium azoles 30%, naphthalene sulfonic acid-formaldehyde condensation product 7%, wetting and penetrating agent F 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 45% glyoxalin triflumizole wettable powder.
Example 39 36% glyoxalin triflumizole water dispersants
Glyoxalin 16%, fluorine bacterium azoles 20%, polyoxyethylene carboxylate 8%, neopelex 7%, bentonite add to 100%, mix and make 36% glyoxalin triflumizole water dispersant.
Example 40 40% glyoxalin triflumizole water dispersants
Glyoxalin 5%, fluorine bacterium azoles 35%, octylphenol polyethylene oxyethylene group ether sulfate 6%, soapberry powder 5%, bentonite add to 100%, mix and make 40% glyoxalin triflumizole water dispersant.
Example 41 20% glyoxalin fluorine bacterium azole suspending agents
Glyoxalin 10%, fluorine bacterium azoles 10%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 5%, silicone compound 0.3%, gum Arabic 1.5%, glycerine 1.2%, deionized water adds to 100%, mixes and makes 20% glyoxalin fluorine bacterium azole suspending agent.
Example 42 30% glyoxalin fluorine bacterium azole suspending agents
Glyoxalin 20%, fluorine bacterium azoles 10%, polycarboxylate 8%, wetting and penetrating agent F 6%, C
10～20saturated fat acids 0.4%, polyethylene glycol 1.5%, deionized water adds to 100%, mixes and makes 30% glyoxalin fluorine bacterium azole suspending agent.
Example 43 15% glyoxalin fluorine bacterium azoles suspension emulsions
Glyoxalin 10%, fluorine bacterium azoles 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5%, silkworm excrement 4%, xanthans 1.5%, propane diols 1.4%, silicone oil 0.6%, agriculture breast 1600#5%, water add to 100%, mix and make 15% glyoxalin fluorine bacterium azoles suspension emulsion.
Example 44 40% glyoxalin fluorine bacterium azoles suspension emulsions
Glyoxalin 10%, fluorine bacterium azoles 30%, lignosulfonates 6%, Nekal BX 5%, PAA 1.2%, ethylene glycol 1.7%, C
8～10aliphatic alcohols 0.5%, Nongru-700 #7%, water add to 100%, mix and make 40% glyoxalin fluorine bacterium azoles suspension emulsion.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Glyoxalin and active component B (B is selected from the one of carbendazim, thiophanate-methyl, probenazole, Prochloraz, imazalil, fluorine bacterium azoles) are composite to crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component glyoxalin and B (carbendazim, thiophanate-methyl, probenazole, Prochloraz, imazalil, fluorine bacterium azoles) shared ratio in combination;
A is glyoxalin;
B is the one in carbendazim, thiophanate-methyl, probenazole, Prochloraz, imazalil, fluorine bacterium azoles.
Application Example two:
Glyoxalin and carbendazim are composite to pear scab Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, carbendazim active compound and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 glyoxalin, carbendazim and the composite toxicity test analysis of results table to pear scab thereof
As shown in Table 1, glyoxalin, the EC of carbendazim to pear scab
50be respectively 0.78mg/L and 9.57mg/L.Glyoxalin and carbendazim proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and carbendazim mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that glyoxalin and carbendazim percentage by weight are 1: 10, synergistic effect is the most obvious.
Application Example three
Glyoxalin and thiophanate-methyl are composite to powdery mildew of cucumber Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, thiophanate methyl raw pesticide and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 glyoxalin, thiophanate-methyl and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 2, glyoxalin, the EC of thiophanate-methyl to powdery mildew of cucumber
50be respectively 0.65mg/L and 6.78mg/L.Glyoxalin and thiophanate-methyl proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and thiophanate-methyl mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 1: 1 to 1: 20, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that glyoxalin and thiophanate-methyl percentage by weight are 1: 10, synergistic effect is the most obvious.
Application Example four
Glyoxalin and probenazole are composite to anthracnose of grape Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, the former medicine of probenazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 glyoxalin, probenazole and the composite toxicity test analysis of results table to anthracnose of grape thereof
As shown in Table 3, glyoxalin, the EC of probenazole to anthracnose of grape
50be respectively 0.56mg/L and 1.94mg/L.Glyoxalin and probenazole proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and probenazole mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 1: 1 to 1: 16, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that glyoxalin and probenazole percentage by weight are 1: 4, synergistic effect is the most obvious.
Application Example five:
Glyoxalin and Prochloraz are composite to apple anthracnose Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, the former medicine of Prochloraz and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 glyoxalin, Prochloraz and the composite toxicity test analysis of results table to apple anthracnose thereof
As shown in Table 4, glyoxalin, the EC of Prochloraz to apple anthracnose
50be respectively 0.51mg/L and 1.86mg/L.Glyoxalin and Prochloraz proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and Prochloraz mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, wherein synergy ratio SR maximum in the time that glyoxalin and Prochloraz percentage by weight are 1: 4, synergistic effect is the most obvious.
Application Example six
Glyoxalin and imazalil are composite to citrus scab Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, the former medicine of imazalil and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 5 glyoxalin, imazalil and the composite toxicity test analysis of results table to citrus scab thereof
As shown in Table 5, glyoxalin, the EC of imazalil to citrus scab
50be respectively 0.72mg/L and 2.83mg/L.Glyoxalin and imazalil proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and imazalil mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, wherein synergy ratio SR maximum in the time that glyoxalin and imazalil percentage by weight are 1: 4, synergistic effect is the most obvious.
Application Example seven
Glyoxalin and fluorine bacterium azoles are composite to pear scab Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining glyoxalin, the former medicine of fluorine bacterium azoles and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 6 glyoxalin, fluorine bacterium azoles and the composite toxicity test analysis of results table to pear scab thereof
As shown in Table 6, glyoxalin, the EC of fluorine bacterium azoles to pear scab
50be respectively 0.65mg/L and 0.74mg/L.Glyoxalin and fluorine bacterium azoles proportioning were at 40: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrate that glyoxalin and fluorine bacterium azoles mixture in 40: 1 to 1: 80 scopes all shows synergistic effect, especially when the two proportioning is during at 10: 1 to 1: 10, synergistic effect is more obviously outstanding, wherein synergy ratio SR maximum in the time that glyoxalin and fluorine bacterium azoles percentage by weight are 1: 1, synergistic effect is the most obvious.
Application Example eight glyoxalins and carbendazim and the composite control pear scab test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 50% carbendazol wettable powder (commercial).
The investigation pear scab state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 7 glyoxalin, carbendazim and the composite control pear scab test of pesticide effectiveness thereof
As can be seen from Table 7, after glyoxalin and carbendazim are composite, can effectively prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example nine glyoxalins and thiophanate-methyl and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan city Linwei district, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 70% thiophanate-methyl wetting powder (commercial).
Investigation powdery mildew of cucumber disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 8 glyoxalin, thiophanate-methyl and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, after glyoxalin and thiophanate-methyl are composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example ten glyoxalins and probenazole and the composite anthracnose of grape test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Baqiao District, Xi'an City, Shanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 42% probenazole suspending agent (commercial).
The investigation anthracnose of grape state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 9 glyoxalin, probenazole and the composite anthracnose of grape test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 9, after glyoxalin and probenazole are composite, can effectively prevent and treat anthracnose of grape, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 11 glyoxalins and Prochloraz and the composite control apple anthracnose test of pesticide effectiveness thereof
This experimental establishment is at Shaanxi Province's Yan’an Luochuan County, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 25% Prochloraz missible oil (commercial).
Investigation apple anthracnose disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 10 glyoxalin, Prochloraz and the composite control apple anthracnose test of pesticide effectiveness thereof
As can be seen from Table 10, after glyoxalin and Prochloraz are composite, can effectively prevent and treat apple anthracnose, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example ten diimine azoles and imazalil and the composite citrus scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Shimen County, Hunan Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 50% Imazalil EC (commercial).
The investigation citrus scab state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 11 glyoxalin, imazalil and the composite citrus scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 11, after glyoxalin and imazalil are composite, can effectively prevent and treat citrus scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example 13 glyoxalins and fluorine bacterium azoles and the composite control pear scab test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Dengcheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 5% glyoxalin wetting powder (commercial), 30% triflumizole wettable powder (commercial).
Investigation pear scab disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser 2 times altogether, investigates disease indexs and calculates preventive effect for after dispenser 7 days, 14 days for the second time.Experimental result is as follows:
Table 12 glyoxalin, the composite control pear scab of the fluorine bacterium azoles test of pesticide effectiveness
As can be seen from Table 12, after glyoxalin and fluorine bacterium azoles are composite, can effectively prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (3)
1. a bactericidal composition that contains glyoxalin, effective active composition is active components A and active component B, it is characterized in that: described active components A is glyoxalin, active component B is thiophanate-methyl, and wherein the weight ratio of glyoxalin and thiophanate-methyl is 40:1～1:80.
2. the bactericidal composition that contains glyoxalin according to claim 1, is characterized in that: the formulation of microbicide compositions is selected from: wetting powder, water dispersible granules, suspending agent, suspension emulsion.
3. the bactericidal composition that contains glyoxalin according to claim 1 is for preventing and treating the purposes of crop scab, ring spot, spot defoliation, anthracnose, anthrachose of grape, shot hole, powdery mildew.
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Effective date of registration: 20180116 Address after: 253411 West Cao village, Ningjin County, Dezhou City, Shandong Province, No. 87 Patentee after: Wang Jinhua Address before: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |
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