CN103749499A - Prothioconazole-containing sterilization composition - Google Patents
Prothioconazole-containing sterilization composition Download PDFInfo
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- CN103749499A CN103749499A CN201310635327.1A CN201310635327A CN103749499A CN 103749499 A CN103749499 A CN 103749499A CN 201310635327 A CN201310635327 A CN 201310635327A CN 103749499 A CN103749499 A CN 103749499A
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- prothioconazoles
- thiophanate
- methyl
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Abstract
A prothioconazole-containing sterilization composition comprises an active component A and an active component B with a weight ratio of 1:80-80:1, wherein the active component A is prothioconazole, and the active component B is one selected from thiophanate-methyl, carbendazim and prochloraz. The sterilization composition can be prepared into wettable powder, water-dispersible granules, a suspending agent, a suspoemulsion, an emulsion in water and a micron emulsion, is used to control diseases such as powdery mildew, sheath blight, fusarium wilt, leaf spot disease, rust disease, sclerotinia rot, virus disease, anthracnose, grey mold, ring rot, bakanae disease, rice blast, early blight, green mold, stem-end rot, blue mold, bipolaris oryzae, cladosporium cucumerinum, damping-off disease and the like, and has the characteristics of being small in pesticide usage amount, resistant to rain scrubbing and obvious in synergy.
Description
The application is for dividing an application, and original application is the patent application " a kind of bactericidal composition containing prothioconazoles " of Shaanxi Mei Bang agricultural chemicals Co., Ltd, and the application number of original application is ︰ 201110237522.X, and original application day is 2011.8.18.
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition containing prothioconazoles in crop pest.
Technical background
Prothioconazoles, English name: prothioconazole molecular formula: C
14h
15cl
2n
3oS chemical name: (RS)-2-[2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl]-2,4-dihydro-1,2,4-triazole-3-thioketones.
Prothioconazoles is a kind of new triazolinones systemic fungicide, as a kind of demethylation inhibitor (DMI), plays precursor-lanosterol demethylation effect on 14-or-24 methylene lanostenols of sterol in Antifungi.By a large amount of field control effectiveness tests, result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase obviously, with triazole type biocide agent, compares, and prothioconazoles has the more sterilization of wide spectrum lives, and the lasting period is long.
Thiophanate-methyl (thiophanate-methyl), molecular formula: C
12h
14n
4o
4s
2, chemical name: 1,2-pair-(3-carbethoxyl group-α-ghiourea group) benzene, thiophanate-methyl belongs to benzimidazole, is a kind of broad spectrum activity systemic fungicide, can prevent and treat various crop disease, has interior suction, preventive and therapeutic action.It is converted into carbendazim in plant corpus, and in the mitosis of interference bacterium, the formation of spindle, affects cell division.
Carbendazim (carbendazim), molecular formula: C
9h
9n
3o
2, chemical name: N-(2-benzimidazolyl) methyl carbamate, carbendazim high-efficiency low-toxicity, effective to sac fungi and imperfect fungus, invalid to oomycetes and bacterial disease, there is protection and therapeutic action.The mechanism of action is the formation of imitative hammer body in the mitosis of interference bacterium, thereby affects cell division.
Prochloraz (prochloraz), molecular formula: C
15h
16cl
3n
3o
2, chemical name: N-propyl group-N-[α-(2,4,6-Trichlorophenoxy)-1H-imidazoles-1-formamide, Prochloraz belongs to imidazoles broad-spectrum germicide.The various crop disease causing for sac fungi and imperfect fungus has special efficacy.By suppressing the biosynthesis of sterol, cause effect.Although do not have a systemic action, it has certain conductive performance.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the drug-fast generation of germ.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance germ.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor research, find prothioconazoles and active component B is mutually composite, there is within the specific limits good synergistic effect, and relevant composite about prothioconazoles and thiophanate-methyl, carbendazim, Prochloraz, there is not yet at present relevant report at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition containing prothioconazoles.
The present invention is achieved through the following technical solutions:
Containing the bactericidal composition of prothioconazoles, it is characterized in that: the weight ratio of active components A and active component B is 1:80～80:1, described active components A is prothioconazoles, active component B is selected from a kind of in thiophanate-methyl, carbendazim, Prochloraz.
The described bactericidal composition containing prothioconazoles, is characterized in that: the weight ratio of prothioconazoles and active component B is 1:60～60:1.
The described bactericidal composition containing prothioconazoles, is characterized in that: the weight ratio of prothioconazoles and active component B is 32:1～1:32.
The described bactericidal composition containing prothioconazoles, is characterized in that: the weight ratio of prothioconazoles and thiophanate-methyl is 8:1～1:16.
The described bactericidal composition containing prothioconazoles, is characterized in that: the weight ratio of prothioconazoles and carbendazim is 8:1～1:16.
The described bactericidal composition containing prothioconazoles, is characterized in that: the weight ratio of prothioconazoles and Prochloraz is 8:1～1:16.
The described bactericidal composition containing prothioconazoles, is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
The described bactericidal composition containing prothioconazoles is for preventing and treating the application of disease on grass family class crop, vegetables, rape, legume crop and fruit tree.
Described application, it is characterized in that, described disease comprises: powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, virus disease, anthracnose, gray mold, ring spot, bakanae disease, rice blast, early blight, green mould, blossom-end rot, penicilliosis, helminthosporium leaf spot, scab, damping off.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in composition, active weight percentage is gross weight 0.5%～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1%～70% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～85% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, can also contain stabilizing agent known in those skilled in the art, antifreeze etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
When making wetting powder, composition comprises following constituent content: prothioconazoles 1%～80%, active component B1%～80%, dispersant 5%～10%, wetting agent 2%～10%, filler 8%～91%.
The former medicine of prothioconazoles, the former medicine of active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: prothioconazoles 1%～80%, active component B1%～80%, dispersant 3%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 1%～8%, filler 10%～92%.
The former medicine of prothioconazoles, the former medicine of active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain preparation materials.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make the water dispersible granules product of the present composition.
When making suspending agent, composition comprises following constituent content: prothioconazoles 1%～40%, active component B1%～40%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.1%～1%, thickener 0.1%～2%, antifreeze 0.1%～8%, stabilizing agent 0.05%～3%, deionized water adds to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formula are mixed through high speed shear, add the former medicine of prothioconazoles, the former medicine of active component B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make the suspending agent product of the present composition.
When making suspension emulsion, composition comprises following constituent content: prothioconazoles 1%～40%, active component B1%～40%, emulsifier 2%～10%, dispersant 2%～10%, defoamer 0.1%～2%, thickener 0.1%～2%, antifreeze 0.1%～8%, stabilizing agent 0.05%～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formula are mixed through high speed shear, add the former medicine of active component B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make active component B suspending agent, then by the former medicine of prothioconazoles, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make the suspension emulsion product of the present composition.
When making aqueous emulsion, composition comprises following constituent content: prothioconazoles 1%～40%, active component B1%～40%, solvent 2%～10%, emulsifier 2%～12%, dispersant 2%～10%, co-emulsifier 0.2%～5%, antifreeze 0.1%～8%, defoamer 0.1%～2%, thickener 0.1%～2%, deionized water adds to 100%.
By having former medicine, solvent, emulsifier, co-emulsifier to be added together in above-mentioned formula, make to be dissolved into even oil phase.By deionized water, dispersant, antifreeze,, defoamer, thickener mix, and becomes homogeneous water, under high-speed stirred, water slowly splashed into oil phase, makes the finely disseminated aqueous emulsion product of the present composition.
When making microemulsion, composition comprises following constituent content: prothioconazoles 1%～40%, active component B1%～40%, and emulsifier 5%～15%, solvent 2%～10%, antifreeze 5%～10%, stabilizing agent 0.5%～3%, deionized water adds to 100%.
Above-mentioned formula Central Plains medicine, solvent, emulsifier are added in mother liquor modulation kettle, make even oil phase, deionized water, antifreeze etc. is mixed and injects product modulation kettle, through high-speed stirred, mix and make the transparent or semitransparent microemulsion product of the present composition.
Beneficial effect of the present invention: (1) present composition active component prothioconazoles and effective active composition B belong to the bactericide of two kinds of different mechanisms of action, and both are mutually mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) with an organic solvent dosage is little in the present invention, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has expanded fungicidal spectrum, and the diseases such as crop powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, virus disease, anthracnose, gray mold, ring spot, bakanae disease, rice blast, early blight, green mould, blossom-end rot, penicilliosis, helminthosporium leaf spot, scab, damping off are all had to special efficacy.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is weight ratio, but the present invention is not limited thereto.
Application Example one
Example 1 70% prothioconazoles thiophanate-methyl wetting powder
Prothioconazoles 5%, thiophanate-methyl 65%, lignosulfonates 5.6%, spaonin powder 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 70% prothioconazoles thiophanate-methyl wetting powder.
Example 2 80% prothioconazoles thiophanate-methyl wetting powders
Prothioconazoles 5%, thiophanate-methyl 75%, lignosulfonates 5%, soapberry powder 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% prothioconazoles thiophanate-methyl wetting powder.
Example 3 60% prothioconazoles thiophanate-methyl water dispersible granules
Prothioconazoles 10%, thiophanate-methyl 50%, naphthalene sulfonic acid-formaldehyde condensation product 6%, Nekal BX 4.5%, sodium bicarbonate 2%, kaolin add to 100%, mix and make 60% prothioconazoles thiophanate-methyl water dispersible granules.
Example 4 75% prothioconazoles thiophanate-methyl water dispersible granules
Prothioconazoles 5%, thiophanate-methyl 70%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, spaonin powder 5%, bentonite add to 100%, mix and make 75% prothioconazoles thiophanate-methyl water dispersible granules.
Example 5 50% prothioconazoles thiophanate-methyl suspending agents
Prothioconazoles 10%, thiophanate-methyl 40%, aryl phenol polyoxyethylene succinate sulfonate 4%, lauryl sodium sulfate 5%, C
10～20saturated fat acids 1.5%, gum Arabic 3.5%, ethylene glycol 1.5%, deionized water add to 100%, mix and make 50% prothioconazoles thiophanate-methyl suspending agent.
Example 6 35% prothioconazoles thiophanate-methyl suspending agents
Prothioconazoles 5%, thiophanate-methyl 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5.5%, lauryl sodium sulfate 6%, C
10～20saturated fat acids 1.2%, sodium phosphate trimer 1.8%, propane diols 1.5%, deionized water add to 100%, mix and make 35% prothioconazoles thiophanate-methyl suspending agent.
Example 7 40% prothioconazoles thiophanate-methyl suspension emulsions
Prothioconazoles 4%, thiophanate-methyl 36%, naphthalene sulfonic acid-formaldehyde condensation product 5%, soapberry powder 4%, polyvinylpyrrolidone 2%, OP series 5%, glycerine 3%, C
10～20saturated fat acids 0.8%, water add to 100%, through mixing, make 40% prothioconazoles thiophanate-methyl suspension emulsion.
Example 8 45% prothioconazoles thiophanate-methyl suspension emulsions
Prothioconazoles 9%, thiophanate-methyl 36%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 4%, gum Arabic 1.5%, By series 5%, ethylene glycol 1.6%, silicone oil 0.5%, water add to 100%, through mixing, make 45% prothioconazoles thiophanate-methyl suspension emulsion.
Example 9 24% prothioconazoles thiophanate-methyl microemulsions
Prothioconazoles 3%, thiophanate-methyl 21%, tween 6%, alkylbenzenesulfonate 5%, phenethyl phenol polyethenoxy ether phosphate 6%, xanthans 3%, propane diols 5%, silicone oil 1.5%, deionized water supplies 100%, mixes and makes 24% prothioconazoles thiophanate-methyl microemulsion.
Example 10 10% prothioconazoles thiophanate-methyl microemulsions
Prothioconazoles 9%, thiophanate-methyl 1%, N-pyrrolidones 4%, ethylene glycol 5%, polyvinyl alcohol 4%, tween series 4%, alkylbenzenesulfonate 3%, silicone oil 1.5%, deionized water supplies 100%, makes 10% prothioconazoles thiophanate-methyl microemulsion.
Example 11 16% prothioconazoles thiophanate-methyl aqueous emulsions
Prothioconazoles 4%, thiophanate-methyl 12%, phenethyl phenol polyethenoxy ether 5%, alkylbenzenesulfonate 5%, OP series 5%, glycerine 4%, gum Arabic 5%, silicone oil 1.5%, deionized water supplies 100%, makes 16% prothioconazoles thiophanate-methyl aqueous emulsion.
Example 12 12% prothioconazoles thiophanate-methyl aqueous emulsions
Prothioconazoles 11%, thiophanate-methyl 1%, castor oil polyoxyethylene ether 5%, OP series 5%, gelatin 1.5%, glycerine 5%, sodium chloride 2%, C
8～10aliphatic alcohols 0.5%, deionized water supplies 100%, makes 12% prothioconazoles thiophanate-methyl aqueous emulsion.
Example 13 78% prothioconazoles carbendazol wettable powders
Prothioconazoles 6%, carbendazim 72%, aryl phenol polyoxyethylene succinate sulfonate 6%, silkworm excrement 4%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 78% prothioconazoles carbendazol wettable powder.
Example 14 65% prothioconazoles carbendazol wettable powders
Prothioconazoles 5%, carbendazim 60%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5%, spaonin powder 4%, diatomite add to 100%, and mixture carries out air-flow crushing, makes 65% prothioconazoles carbendazol wettable powder.
Example 15 64% prothioconazoles carbendazim water dispersing granules
Prothioconazoles 8%, carbendazim 56%, polycarboxylate 6%, lauryl sodium sulfate 5%, ammonium sulfate 3%, diatomite add to 100%, mix and make 64% prothioconazoles carbendazim water dispersing granule.
Example 16 70% prothioconazoles carbendazim water dispersing granules
Prothioconazoles 10%, carbendazim 60%, lignosulfonates 6%, neopelex 6%, bentonite add to 100%, mix and make 70% prothioconazoles carbendazim water dispersing granule.
Example 17 40% prothioconazoles carbendazim suspending agents
Prothioconazoles 10%, carbendazim 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, silkworm excrement 5%, C
10～20saturated fat acids 1.8%, xanthans 1.8%, propane diols 3%, deionized water add to 100%, mix and make 40% prothioconazoles carbendazim suspending agent.
Example 18 45% prothioconazoles carbendazim suspending agents
Prothioconazoles 9%, carbendazim 36%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 5%, silicone compound 1.5%, gum Arabic 2.5%, ethylene glycol 3%, deionized water add to 100%, mix and make 45% prothioconazoles carbendazim suspending agent.
Example 19 45% prothioconazoles carbendazim suspension emulsions
Prothioconazoles 5%, carbendazim 40%, naphthalene sulfonic acid-formaldehyde condensation product 6%, Nekal BX 6%, silicone compound 2%, triphenyl phosphite 2%, polyvinylpyrrolidone 2%, Nongru-700 #5%, ethylene glycol 1.5%, water add to 100%, aforementioned formula material is mixed, make 45% prothioconazoles carbendazim suspension emulsion.
Example 20 38% prothioconazoles carbendazim suspension emulsions
Prothioconazoles 8%, carbendazim 30%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 5%, silicone oil 1.5%, polyvinylpyrrolidone 1.5%, tween series 5%, polyethylene glycol 3%, water add to 100%, aforementioned formula material is mixed, make 38% prothioconazoles carbendazim suspension emulsion.
Example 21 20% prothioconazoles Bavistin microemulsions
Prothioconazoles 19%, carbendazim 1%, styrene polyoxyethylene ether ammonium sulfate salt 6%, cyclohexanone 3%, glycerine 8%, silicone 1.5%, deionized water adds to 100%, through mixing, makes 20% prothioconazoles Bavistin microemulsion.
Example 22 18% prothioconazoles Bavistin microemulsions
Prothioconazoles 15%, carbendazim 3%, By series 8%, ethylene glycol monomethyl ether 3%, polyethylene glycol 5%, C
8～10aliphatic alcohols 1%, deionized water adds to 100%, through mixing, makes 18% prothioconazoles Bavistin microemulsion.
Example 23 45% prothioconazoles carbendazim aqueous emulsions
Prothioconazoles 44%, carbendazim 1%, NOP 5%, agriculture breast 1800
#6%, calcium chloride 3%, glycerine 4%, silicone 1.5%, deionized water adds to 100%, through mixing, makes 45% prothioconazoles carbendazim aqueous emulsion.
Example 24 22% prothioconazoles carbendazim aqueous emulsions
Prothioconazoles 11%, carbendazim 11%, DMF 5%, alkyl biphenyl ether disulfonic acid magnesium salts 5%, butanols 3%, ethylene glycol 5%, C
8～10aliphatic alcohols 1.5%, deionized water adds to 100%, through mixing, makes 22% prothioconazoles carbendazim aqueous emulsion.
Example 25 78% prothioconazoles Prochloraz wetting powders
Prothioconazoles 1%, Prochloraz 77%, polycarboxylate 7%, soapberry powder 4%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 78% prothioconazoles Prochloraz wetting powder.
Example 26 56% prothioconazoles Prochloraz wetting powders
Prothioconazoles 6%, Prochloraz 50%, naphthalene sulfonic acid-formaldehyde condensation product 6%, silkworm excrement 5%, starch add to 100%, and mixture carries out air-flow crushing, make 56% prothioconazoles Prochloraz wetting powder.
Example 27 65% prothioconazoles Prochloraz water dispersible granules
Prothioconazoles 10%, Prochloraz 55%, polyoxyethylene carboxylate 6%, neopelex 5%, bentonite add to 100%, mix and make 65% prothioconazoles Prochloraz water dispersible granules.
Example 28 48% prothioconazoles Prochloraz water dispersible granules
Prothioconazoles 6%, Prochloraz 42%, lignosulfonates 6%, lauryl sodium sulfate 6%, sodium bicarbonate 2%, kaolin add to 100%, mix and make 48% prothioconazoles Prochloraz water dispersible granules.
Example 29 40% prothioconazoles Prochloraz suspending agents
Prothioconazoles 10%, Prochloraz 30%, polycarboxylate 6%, lauryl sodium sulfate 5%, silicone oil 1.5%, gum Arabic 1.5%, glycerine 1.5%, deionized water adds to 100%, mixes and makes 40% prothioconazoles Prochloraz suspending agent.
Example 30 25% prothioconazoles Prochloraz suspending agents
Prothioconazoles 20%, Prochloraz 5%, aryl phenol polyoxyethylene succinate sulfonate 6%, lauryl sodium sulfate 6%, silicone compound 1.5%, polyvinylpyrrolidone 1.5%, polyethylene glycol 1.5%, deionized water adds to 100%, mixes and makes 25% prothioconazoles Prochloraz suspending agent.
Example 31 45% prothioconazoles Prochloraz suspension emulsions
Prothioconazoles 15%, Prochloraz 30%, polyoxyethylene carboxylate 6%, lauryl sodium sulfate 5%, polyvinylpyrrolidone 1.5%, polyethylene glycol 2%, C
10～20saturated fat acids 0.8%, agriculture breast 600#6%, water add to 100%, mix and make 45% prothioconazoles Prochloraz suspension emulsion.
Example 32 28% prothioconazoles Prochloraz suspension emulsions
Prothioconazoles 21%, Prochloraz 7%, aryl phenol polyoxyethylene succinate sulfonate 7%, soapberry powder 5%, sodium phosphate trimer 1.5%, ethylene glycol 1.5%, C
10～20saturated fat acids 0.5%, OP series 6%, water add to 100%, mix and make 28% prothioconazoles Prochloraz suspension emulsion.
Example 33 40% prothioconazoles Prochloraz microemulsions
Prothioconazoles 2%, Prochloraz 38%, alkylphenol polyoxyethylene phosphate 6%, N-pyrrolidones 5%, castor oil polyoxyethylene ether 5%, gelatin 2%, glycerine 3%, silicone oil 0.5%, deionized water supplies 100%, mixes and makes 40% prothioconazoles Prochloraz microemulsion.
Example 34 30% prothioconazoles Prochloraz microemulsions
Prothioconazoles 15%, Prochloraz 15%, N-pyrrolidones 5%, ethylene glycol 5%, polyvinyl alcohol 2%, tween series 5%, alkylbenzenesulfonate 3%, silicone oil 0.8%, deionized water supplies 100%, makes 30% prothioconazoles Prochloraz microemulsion.
Example 35 48% prothioconazoles prochloraz aqueous emulsions
Prothioconazoles 47%, Prochloraz 1%, alkylbenzenesulfonate 4%, alkylphenol polyoxyethylene 5%, OP series 7%, propane diols 4%, polyvinyl alcohol 2%, silicone oil 0.8%, deionized water supplies 100%, makes 48% prothioconazoles prochloraz aqueous emulsion.
Example 36 36% prothioconazoles prochloraz aqueous emulsions
Prothioconazoles 9%, Prochloraz 27%, fatty alcohol-polyoxyethylene ether 6%, alkylbenzenesulfonate 4%, agriculture breast 33#5%, polyethylene glycol 5%, gelatin 2%, silicone oil 0.8%, deionized water supplies 100%, makes 36% prothioconazoles prochloraz aqueous emulsion.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Prothioconazoles and active component B(B are selected from a kind of in thiophanate-methyl, carbendazim, Prochloraz) composite to crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component prothioconazoles and active component B(thiophanate-methyl, carbendazim, Prochloraz) shared ratio in combination;
A is prothioconazoles;
B is a kind of in thiophanate-methyl, carbendazim, Prochloraz.
Implementation of an application example two:
Prothioconazoles and thiophanate-methyl are composite to stalk break Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining prothioconazoles and thiophanate methyl raw pesticide and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 prothioconazoles and thiophanate-methyl and the composite toxicity test analysis of results table to stalk break thereof
As shown in Table 1, prothioconazoles and the thiophanate-methyl EC to stalk break
50be respectively 4.05mg/L and 13.65mg/L.Prothioconazoles and thiophanate-methyl proportioning are when 80:1 to 1:80, synergy ratio SR is all greater than 1.5, illustrate that prothioconazoles and thiophanate-methyl are mixed and all show synergistic effect in 80:1 to 1:80 scope, especially when the two proportioning is during at 4:1 to 1:16, wherein prothioconazoles and thiophanate-methyl proportioning are at 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10 is more remarkable to stalk break and virus disease synergistic effect, wherein when prothioconazoles and thiophanate-methyl weight ratio are 1:4, synergy ratio SR is maximum, synergistic effect is the most obvious.
Implementation of an application example three:
Prothioconazoles and carbendazim are composite to wheat powdery mildew Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining prothioconazoles and carbendazim active compound and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 prothioconazoles and carbendazim and the composite toxicity test analysis of results table to wheat powdery mildew thereof
As shown in Table 2, prothioconazoles and the carbendazim EC to wheat powdery mildew
50be respectively 3.98mg/L and 13.57mg/L.Prothioconazoles and carbendazim proportioning are when 80:1 to 1:80, synergy ratio SR is all greater than 1.5, illustrate that prothioconazoles and carbendazim are mixed and all show synergistic effect in 80:1 to 1:80 scope, especially working as prothioconazoles and carbendazim proportioning is that 4:1 to 1:16 synergistic effect is the most obvious, wherein the two proportioning is at 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, more remarkable to powdery mildew and smut synergistic effect during 1:10, especially when the proportioning of prothioconazoles and carbendazim is during at 1:4, synergy ratio SR is maximum, synergistic effect is the most remarkable.
Implementation of an application example four
Prothioconazoles and Prochloraz are composite to citrus common green mold Toxicity Determination.
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
Experimental scheme: effective inhibition concentration scope of determining the former medicine of prothioconazoles and Prochloraz and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 prothioconazoles and Prochloraz and the composite toxicity test analysis of results table to citrus common green mold thereof
As shown in Table 3, prothioconazoles and the Prochloraz EC to citrus common green mold
50be respectively 3.87mg/L and 6.24mg/L.Prothioconazoles and Prochloraz proportioning are when 80:1 to 1:80, synergy ratio SR is all greater than 1.5, illustrate that prothioconazoles and Prochloraz are mixed and all show synergistic effect in 80:1 to 1:80 scope, especially when prothioconazoles and Prochloraz proportioning are 8:1 to 1:16, synergistic effect is the most remarkable, wherein the two proportioning is at 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10 is best to green mould and penicilliosis preventive effect, especially when the proportioning of prothioconazoles and Prochloraz is during at 1:2, synergy ratio SR is maximum, synergistic effect is the most obvious.
Application Example five prothioconazoles and thiophanate-methyl and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in suburb, Jingzhou City, Hebei province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 40% prothioconazoles wetting powder (autogamy), 36% thiophanate-methyl suspending agent (commercial).
The investigation rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 3 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 4 prothioconazoles and thiophanate-methyl and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 4, after prothioconazoles and thiophanate-methyl are composite, can effectively prevent and treat rice blast, control efficiency is all better than the preventive effect of single dose, through test people, find, prothioconazoles and thiophanate-methyl are composite rear better to preventing and treating rice sheath blight disease preventive effect, after medicine, 30 days preventive effects reach 85%, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example six prothioconazoles and carbendazim and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan City suburb, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 40% prothioconazoles wetting powder (autogamy), 80% carbendazim water dispersing granule (commercial).
The investigation early blight of tomato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 3 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 5 prothioconazoles and carbendazim and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 5, after prothioconazoles and carbendazim are composite, can effectively prevent and treat early blight of tomato, control efficiency is all better than the preventive effect of single dose, through test people, find, the melon anthracnose preventive effect of the composite rear control of prothioconazoles and carbendazim is also better, and after medicine, 30 rear preventive effects reach more than 85%, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven prothioconazoles and Prochloraz and the composite bakanae disease of rice test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Mianyang City suburb, Sichuan Province, and test medicine is researched and developed, provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 40% prothioconazoles wetting powder (autogamy), 25% prochloraz aqueous emulsion (commercial).
Investigation bakanae disease of rice disease index before medicine, in their early stage dispenser, every dispenser on the 7th once, dispenser is 2 times altogether, within after dispenser 3 days, 14 days, 30 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 6 prothioconazoles, the composite bakanae disease of rice test of pesticide effectiveness of preventing and treating of Prochloraz
As can be seen from Table 6, after prothioconazoles and Prochloraz are composite, can effectively prevent and treat bakanae disease of rice, control efficiency is all better than the preventive effect of single dose, through test people, find, prothioconazoles and Prochloraz are composite rear better to preventing and treating Hemintho-sporum leaf spot of rice plants preventive effect, and after medicine, 30 days preventive effects reach 85%, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Claims (6)
1. containing a bactericidal composition for prothioconazoles, it is characterized in that: active component is prothioconazoles and thiophanate-methyl, the weight ratio of prothioconazoles and thiophanate-methyl is 1:80～80:1.
2. the bactericidal composition containing prothioconazoles according to claim 1, is characterized in that: the weight ratio of prothioconazoles and thiophanate-methyl is 1:60～60:1.
3. the bactericidal composition containing prothioconazoles according to claim 2, is characterized in that: the weight ratio of prothioconazoles and thiophanate-methyl is 8:1～1:16.
4. according to the bactericidal composition containing prothioconazoles described in any one in claims 1 to 3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
5. the bactericidal composition containing prothioconazoles according to claim 4 is for preventing and treating the application of disease on grass family class crop, vegetables, rape, legume crop and fruit tree.
6. application according to claim 5, it is characterized in that, described disease is powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, virus disease, anthracnose, gray mold, ring spot, bakanae disease, rice blast, early blight, green mould, blossom-end rot, penicilliosis, helminthosporium leaf spot, scab, damping off.
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| CN103918693A (en) * | 2014-03-31 | 2014-07-16 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and prochloraz |
| CN104642367A (en) * | 2013-11-15 | 2015-05-27 | 南京华洲药业有限公司 | Bactericidal composition containing prothioconazole and prochloraz and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| WO2009147205A2 (en) * | 2008-06-05 | 2009-12-10 | Basf Se | Synergistic fungicidal mixtures |
| EP2239331A1 (en) * | 2009-04-07 | 2010-10-13 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| WO2009147205A2 (en) * | 2008-06-05 | 2009-12-10 | Basf Se | Synergistic fungicidal mixtures |
| EP2239331A1 (en) * | 2009-04-07 | 2010-10-13 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642367A (en) * | 2013-11-15 | 2015-05-27 | 南京华洲药业有限公司 | Bactericidal composition containing prothioconazole and prochloraz and application thereof |
| CN103918693A (en) * | 2014-03-31 | 2014-07-16 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and prochloraz |
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