CN102057913B - Bactericidal composition containing triflumizole and triazole compound - Google Patents
Bactericidal composition containing triflumizole and triazole compound Download PDFInfo
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- CN102057913B CN102057913B CN201010600821.0A CN201010600821A CN102057913B CN 102057913 B CN102057913 B CN 102057913B CN 201010600821 A CN201010600821 A CN 201010600821A CN 102057913 B CN102057913 B CN 102057913B
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- fluorine bacterium
- bacterium azoles
- azoles
- flusilazole
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Abstract
The invention discloses a bactericidal composition containing triflumizole and a triazole compound. The bactericidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is the triflumizole; the active ingredient B is any one of the following bactericides: diniconazole, triadimefon, flusilazole and cyproconazole; and the weight part ratio of the active ingredient A to the active ingredient B is (2-78):(2-78). The composition can prevent various diseases such as powdery mildew, alternaria leaf spot, scab, leaf spot, anthracnose and the like of crops, has obvious synergism, and high safety for the crops, and has the advantages of rain wash resistance, lasting bactericide effect and the like.
Description
Technical field
The invention belongs to agriculture chemicals fungicide field, relate to a kind of preparation and application of the bactericidal composition that contains two active components.
Background technology
Fluorine bacterium azoles (triflumizole), chemical name: the chloro-α of (E)-4-, α, the o-toluidines fluorine bacterium azoles of the fluoro-N-of α-tri-(1-imidazoles-1-base-α-the third oxygen ethylidene), molecular formula: C
15h
15n
3f
3clO, structural formula:
fluorine bacterium azoles is ergosterol biosynthesis inhibitor.Have prevention, treat, root out effect, systemic action conductivity is good, and anti-rain drop erosion can anti-various crop disease.The scope of application: be applicable to the control of the powdery mildews such as wheat class, fruit tree, vegetables, rust, peach brown rot.
Summary of the invention
The long-term use of fluorine bacterium azoles single dose may bring degradation problem under resistance generation, drug effect.The bactericidal composition that the present invention proposes contains A, two kinds of active components of B, and appropriate surfactant and carrier.Effective active composition A and effective active composition B ratio of weight and number are 2～78: 2～78, and active component A is selected from fluorine bacterium azoles, and active component B is a kind of in alkene azoles alcohol, triazolone, Flusilazole or cyproconazole.
Described a kind of bactericidal composition that contains fluorine bacterium azoles and triazole class compounds, is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 5～65: 5～65.
The described bactericidal composition that contains fluorine bacterium azoles, is characterized in that: the ratio of weight and number of fluorine bacterium azoles and alkene azoles alcohol is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles, is characterized in that: the ratio of weight and number of fluorine bacterium azoles and triazolone is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles, is characterized in that: the ratio of weight and number of fluorine bacterium azoles and Flusilazole is 10～35: 10～35.
The described bactericidal composition that contains fluorine bacterium azoles, is characterized in that: the ratio of weight and number of fluorine bacterium azoles and cyproconazole is 10～35: 10～35.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in composition, active weight percentage is gross weight 0.5～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1～70% active substance by weight, is preferably 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, can also contain stabilizing agent known in those skilled in the art, antifreeze etc.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described thickener is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described emulsifier is selected from: agriculture breast 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400# (benzyl dimethyl phenol polyoxy ethyl ether), agriculture breast 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), agriculture breast 36# (phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), agriculture breast 33# (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Described stabilizing agent is selected from: one or more in BHT, triphenyl phosphite, epoxychloropropane, tributyl phosphate, triethanolamine, diethanol amine, monoethanolamine.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after being about to active substance and mixing with liquid flux or solid carrier, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer, stabilizing agent etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein comparatively preferably there are wetting powder, water dispersible granules, suspending agent or suspension emulsion.
When making wetting powder, composition comprises following constituent content: fluorine bacterium azoles 2～78%, effective active composition B2～78%, dispersant 5～10%, wetting agent 2～10%, filler 8～89%.
The former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.
When making water dispersible granules, composition comprises following constituent content: fluorine bacterium azoles 2～78%, effective active composition B2～78%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
The former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make water dispersible granules product of the present invention.
When making suspending agent, composition comprises following constituent content: fluorine bacterium azoles 2～30%, effective active composition B2～30%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, deionized water adds to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add the former medicine of fluorine bacterium azoles, the former medicine of effective active composition B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
When making suspension emulsion, composition comprises following constituent content: fluorine bacterium azoles 2～30%, effective active composition B 2～30%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of effective active composition B, in ball mill, ball milling is 2～3 hours, make diameter of particle all below 5 μ m, make effective active composition B suspending agent, then by the former medicine of fluorine bacterium azoles, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make B suspension emulsion product of the present invention.
The bactericidal composition of described containing triflumizole and active component B is for preventing and treating disease due to the germ of sub-Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti, available with for example permitted various crop: fruit tree, wheat, cucumber, grape, vegetables and flowers and paddy rice, preventing and treating Basidiomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny especially has good preventive effect to the microbial disease of basidiomycetes, imperfect fungus and ascus as powdery mildew, scab, spot defoliation, rust, leaf spot, leaf blight, anthracnose, downy mildew, brown spot, epidemic disease etc.
Beneficial effect of the present invention: (1) is because the mechanism of action of single dose in said composition is different, there is not the problem of cross resistance, so, the application of said composition can reach and delay the drug-fast generation of pathogen and development, contribute to extend the result of use of this medicament, reduce the object that pesticide resistance produces probability; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) with an organic solvent dosage is few in the present invention, is difficult for producing poisoning, is convenient to transportation and storage, has improved safety, and being mixed will be lower on the impact of environment, safer.(4) present composition has expanded fungicidal spectrum, and powdery mildew, scab, spot defoliation, rust, leaf spot, leaf blight, anthracnose, downy mildew, brown spot, epidemic disease etc. are had to special efficacy.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1 45% fluorine bacterium azoles alkene azoles alcohol wetting powder
Fluorine bacterium azoles 35%, alkene azoles alcohol 10%, polycarboxylate 6%, soapberry powder 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 45% fluorine bacterium azoles alkene azoles alcohol wetting powder.
Embodiment 2 80% fluorine bacterium azoles alkene azoles alcohol wetting powders
Fluorine bacterium azoles 75%, alkene azoles alcohol 5%, alkylnaphthalene sulfonate 5%, spaonin powder 5%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% fluorine bacterium azoles alkene azoles alcohol wetting powder.
Embodiment 3 40% fluorine bacterium azoles diniconazole water dispersible granules
Fluorine bacterium azoles 20%, alkene azoles alcohol 20%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 5%, aluminium chloride 1%, bentonite add to 100%, mix and make 40% fluorine bacterium azoles diniconazole water dispersible granule.
Embodiment 4 60% fluorine bacterium azoles diniconazole water dispersible granules
Fluorine bacterium azoles 10%, alkene azoles alcohol 50%, aryl phenol polyoxyethylene succinate sulfonate 7%, wetting and penetrating agent F 5%, bentonite add to 100%, mix and make 60% fluorine bacterium azoles diniconazole water dispersible granule.
Embodiment 5 36% fluorine bacterium azoles diniconazole suspending agents
Fluorine bacterium azoles 20%, alkene azoles alcohol 16%, lignosulfonates 6%, neopelex 4%, silicone oil 0.4%, xanthans 0.6%, propane diols 1.5%, deionized water add to 100%, mix and make 36% fluorine bacterium azoles diniconazole suspending agent.
Embodiment 6 42% fluorine bacterium azoles diniconazole suspending agents
Fluorine bacterium azoles 10%, alkene azoles alcohol 32%, polyoxyethylene carboxylate 6%, Nekal BX 4%, C
8～10aliphatic alcohols 0.3%, gum Arabic 0.7%, glycerine 2%, deionized water add to 100%, mix and make 42% fluorine bacterium azoles diniconazole suspending agent.
Embodiment 7 20% fluorine bacterium azoles alkene azoles alcohol suspension emulsions
Fluorine bacterium azoles 10%, alkene azoles alcohol 10%, alkyl benzene sulfonate calcium salt 5%, soapberry powder 3%, ethylene glycol 1%, silicone oil 0.5%, tween series 5%, xanthans 1.3%, water add to 100%, mix and make 20% fluorine bacterium azoles alkene azoles alcohol suspension emulsion.
Embodiment 8 48% fluorine bacterium azoles alkene azoles alcohol suspension emulsions
Fluorine bacterium azoles 36%, alkene azoles alcohol 12%, the phonetic formaldehyde condensation products sulphate 4% of alkylphenol-polyethenoxy, neopelex 5%, agriculture breast 500#6%, C
8～10aliphatic alcohols 0.3%, polyethylene glycol 1.5%, polyvinylpyrrolidone 1.2%, water add to 100%, mix and make 48% fluorine bacterium azoles alkene azoles alcohol suspension emulsion.
Embodiment 9 45% fluorine bacterium azoles trazodone wettable powders
Fluorine bacterium azoles 15%, triazolone 30%, alkyl benzene sulfonate calcium salt 7%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 45% fluorine bacterium azoles trazodone wettable powder.
Embodiment 10 80% fluorine bacterium azoles trazodone wettable powders
Fluorine bacterium azoles 20%, triazolone 60%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, wetting and penetrating agent F 6%, white carbon add to 100%, and mixture carries out air-flow crushing, make 80% fluorine bacterium azoles trazodone wettable powder.
Embodiment 11 32% fluorine bacterium azoles triazolone water dispersible granules
Fluorine bacterium azoles 8%, triazolone 24%, polyoxyethylene carboxylate 6%, Nekal BX 5%, ammonium sulfate 1%, kaolin add to 100%, mix and make 32% fluorine bacterium azoles triazolone water dispersible granules.
Embodiment 12 60% fluorine bacterium azoles triazolone water dispersible granules
Fluorine bacterium azoles 10%, triazolone 50%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, spaonin powder 5%, urea 1%, bentonite add to 100%, mix and make 60% fluorine bacterium azoles triazolone water dispersible granules.
Embodiment 13 30% fluorine bacterium azoles triazolone suspending agents
Fluorine bacterium azoles 10%, triazolone 20%, lignosulfonates 6%, wetting and penetrating agent F 3%, silicone compound 0.5%, gum Arabic 1%, polyethylene glycol 1.5%, deionized water add to 100%, mix and make 30% fluorine bacterium azoles triazolone suspending agent.
Embodiment 14 48% fluorine bacterium azoles triazolone suspending agents
Fluorine bacterium azoles 24%, triazolone 24%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, Nekal BX 4%, silicone oil 0.2%, sodium phosphate trimer 0.8%, propane diols 1%, deionized water add to 100%, mix and make 48% fluorine bacterium azoles triazolone suspending agent.
Embodiment 15 16% fluorine bacterium azoles triazolone suspension emulsions
Fluorine bacterium azoles 12%, triazolone 4%, polyoxyethylene carboxylate 6%, lauryl sodium sulfate 4%, C
8～10aliphatic alcohols 0.2%, polyvinylpyrrolidone 1.5%, agriculture breast 1600#6%, polyethylene glycol 1.6%, water add to 100%, and aforementioned formula material is mixed, and make 16% fluorine bacterium azoles triazolone suspension emulsion.
Embodiment 16 40% fluorine bacterium azoles triazolone suspension emulsions
Fluorine bacterium azoles 4%, triazolone 36%, alkylnaphthalene sulfonate 8%, wetting and penetrating agent F 6%, methylcellulose 1%, ethylene glycol 1.5%, C
8～10aliphatic alcohols 0.5%, Nongru-700 #6%, water add to 100%, through mixing, make 40% fluorine bacterium azoles triazolone suspension emulsion.
Embodiment 17 35% fluorine bacterium azoles Flusilazole wetting powders
Fluorine bacterium azoles 15%, Flusilazole 20%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, silkworm excrement 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 35% fluorine bacterium azoles Flusilazole wetting powder.
Embodiment 18 70% fluorine bacterium azoles Flusilazole wetting powders
Fluorine bacterium azoles 7%, Flusilazole 63%, polyoxyethylene carboxylate 7%, lauryl sodium sulfate 4%, diatomite add to 100%, and mixture carries out air-flow crushing, make 70% fluorine bacterium azoles Flusilazole wetting powder.
Embodiment 19 40% fluorine bacterium azoles flusilazole water dispersible granules
Fluorine bacterium azoles 5%, Flusilazole 35%, alkyl benzene sulfonate calcium salt 6%, wetting and penetrating agent F 5%, aluminium chloride 0.8%, bentonite add to 100%, mix and make 40% fluorine bacterium azoles flusilazole water dispersible granule.
Embodiment 20 60% fluorine bacterium azoles flusilazole water dispersible granules
Fluorine bacterium azoles 45%, Flusilazole 15%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 5%, urea 1.2%, attapulgite add to 100%, mix and make 60% fluorine bacterium azoles flusilazole water dispersible granule.
Embodiment 21 30% fluorine bacterium azoles Flusilazole suspending agents
Fluorine bacterium azoles 15%, Flusilazole 15%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, spaonin powder 4%, silicone oil 0.5%, xanthans 0.8%, glycerine 1.2%, deionized water add to 100%, mix and make 30% fluorine bacterium azoles Flusilazole suspending agent.
Embodiment 22 40% fluorine bacterium azoles Flusilazole suspending agents
Fluorine bacterium azoles 30%, Flusilazole 10%, polycarboxylate 7%, lauryl sodium sulfate 6%, C
8～10aliphatic alcohols 0.4%, polyvinyl alcohol 0.9%, ethylene glycol 1.4%, deionized water add to 100%, mix and make 40% fluorine bacterium azoles Flusilazole suspending agent.
Embodiment 23 10% fluorine bacterium azoles Flusilazole suspension emulsions
Fluorine bacterium azoles 5%, Flusilazole 5%, alkyl benzene sulfonate calcium salt 8%, wetting and penetrating agent F 4%, silicone compound 0.2%, sodium phosphate trimer 1.5%, agriculture breast 1600#6%, propane diols 1.8%, water add to 100%, aforementioned formula material is mixed, make 10% fluorine bacterium azoles Flusilazole suspension emulsion.
Embodiment 24 38% fluorine bacterium azoles Flusilazole suspension emulsions
Fluorine bacterium azoles 20%, Flusilazole 18%, aryl phenol polyoxyethylene succinate sulfonate 7%, soapberry powder 5%, gum Arabic 1.8%, OP series 6%, propane diols 2%, C10～20 saturated fat acids 0.3%, triphenyl phosphite 0.4%, water add to 100%, through mixing, make 38% fluorine bacterium azoles Flusilazole suspension emulsion.
Embodiment 25 44% fluorine bacterium azoles cyproconazole wetting powders
Fluorine bacterium azoles 30%, cyproconazole 14%, lignosulfonates 5%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 44% fluorine bacterium azoles cyproconazole wetting powder.
Embodiment 26 55% fluorine bacterium azoles cyproconazole wetting powders
Fluorine bacterium azoles 35%, cyproconazole 20%, alkyl benzene sulfonate calcium salt 9%, silkworm excrement 6%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow crushing, make 55% fluorine bacterium azoles cyproconazole wetting powder.
Embodiment 27 40% fluorine bacterium azoles cyproconazole water dispersible granules
Fluorine bacterium azoles 25%, cyproconazole 15%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 5%, spaonin powder 3%, ammonium sulfate 0.8%, kaolin add to 100%, mix and make 40% fluorine bacterium azoles cyproconazole water dispersible granules.
Embodiment 28 64% fluorine bacterium azoles cyproconazole water dispersible granules
Fluorine bacterium azoles 24%, cyproconazole 40%, the phonetic formaldehyde condensation products sulphate 6% of alkylphenol-polyethenoxy, lauryl sodium sulfate 4%, aluminium chloride 0.6%, bentonite add to 100%, mix and make 64% fluorine bacterium azoles cyproconazole water dispersible granules.
Embodiment 29 24% fluorine bacterium azoles cyproconazole suspending agents
Fluorine bacterium azoles 16%, cyproconazole 8%, polycarboxylate 4%, Nekal BX 4%, C
10～20saturated fat acids 0.5%, gum Arabic 0.8%, ethylene glycol 1.4%, deionized water add to 100%, mix and make 24% fluorine bacterium azoles cyproconazole suspending agent.
Embodiment 30 45% fluorine bacterium azoles cyproconazole suspending agents
Fluorine bacterium azoles 30%, cyproconazole 15%, polyoxyethylene carboxylate 8%, soapberry powder 6%, C
8～10aliphatic alcohols 0.4%, sodium phosphate trimer 1%, propane diols 1%, deionized water add to 100%, mix and make 45% fluorine bacterium azoles cyproconazole suspending agent.
Embodiment 31 25% fluorine bacterium azoles cyproconazole suspension emulsions
Fluorine bacterium azoles 20%, cyproconazole 5%, lignosulfonates 6%, wetting and penetrating agent F 4%, silicone compound 0.5%, polyvinylpyrrolidone 1.4%, propane diols 6%, agriculture breast 34#6%, water add to 100%, aforementioned formula material is mixed, make 25% fluorine bacterium azoles cyproconazole suspension emulsion.
Embodiment 32 36% fluorine bacterium azoles cyproconazole suspension emulsions
Fluorine bacterium azoles 24%, cyproconazole 12%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, lauryl sodium sulfate 4%, xanthans 1.4%, polyethylene glycol 1%, silicone oil 0.2%, 600# phosphate 7%, epoxychloropropane 0.8%, water add to 100%, through mixing, make 36% fluorine bacterium azoles cyproconazole suspension emulsion.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Fluorine bacterium azoles and active component B (B is selected from a kind of of alkene azoles alcohol, triazolone, Flusilazole, cyproconazole) are composite to crop pest Toxicity Determination.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component fluorine bacterium azoles and active component B (alkene azoles alcohol, triazolone, Flusilazole, cyproconazole) shared ratio in combination;
A is fluorine bacterium azoles;
B is a kind of in alkene azoles alcohol, triazolone, Flusilazole, cyproconazole.
Implementation of an application example two:
Fluorine bacterium azoles and alkene azoles alcohol are composite to alternaria leaf spot of apple Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of alkene azoles alcohol and the two different proportioning mixture through preliminary experiment.
Toxicity test result
It is as shown in the table for result of the test:
Table 1 fluorine bacterium azoles, alkene azoles alcohol and the composite toxicity test analysis of results table to alternaria leaf spot of apple thereof
As shown in Table 1, fluorine bacterium azoles, the EC of alkene azoles alcohol to alternaria leaf spot of apple
50be respectively 2.35mg/L and 1.86mg/L.Fluorine bacterium azoles and alkene azoles alcohol proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluorine bacterium azoles and alkene azoles alcohol were mixed in scope and all show synergistic effect at 39: 1 to 1: 39, especially when the two proportioning is during at 10: 1 to 1: 10, synergistic effect is more obviously outstanding, wherein when fluorine bacterium azoles and alkene azoles alcohol weight ratio are 1: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example three
Fluorine bacterium azoles and triazolone are composite to wheat powdery mildew Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of triazolone and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 2 fluorine bacterium azoles, triazolone and the composite toxicity test analysis of results table to wheat powdery mildew thereof
As shown in Table 2, fluorine bacterium azoles, the EC of triazolone to wheat powdery mildew
50be respectively 1.02mg/L and 1.73mg/L.Fluorine bacterium azoles and triazolone proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluorine bacterium azoles and triazolone were mixed in scope and all show synergistic effect at 39: 1 to 1: 39, especially when the two proportioning is during at 9: 1 to 1: 9, synergistic effect is more obviously outstanding, wherein when fluorine bacterium azoles and triazolone weight ratio are 1: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example four
Fluorine bacterium azoles and Flusilazole are composite to powdery mildew of cucumber Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, flusilazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 3 fluorine bacterium azoles, Flusilazole and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 3, fluorine bacterium azoles, the EC of Flusilazole to powdery mildew of cucumber
50be respectively 0.68mg/L and 0.42mg/L.Fluorine bacterium azoles and Flusilazole proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluorine bacterium azoles and Flusilazole were mixed in scope and all show synergistic effect at 39: 1 to 1: 39, especially when the two proportioning is during at 9: 1 to 1: 9, synergistic effect is more obviously outstanding, wherein when fluorine bacterium azoles and Flusilazole weight ratio are 1: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Implementation of an application example five
Fluorine bacterium azoles and cyproconazole are composite to pear scab Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: effective inhibition concentration scope of determining fluorine bacterium azoles, the former medicine of cyproconazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 4 fluorine bacterium azoles, cyproconazole and the composite toxicity test analysis of results table to pear scab thereof
As shown in Table 4, fluorine bacterium azoles, the EC of cyproconazole to pear scab
50be respectively 2.05mg/L and 0.89mg/L.Fluorine bacterium azoles and cyproconazole proportioning were at 39: 1 to 1: 39 o'clock, synergy ratio SR is all greater than 1.5, illustrate that fluorine bacterium azoles and cyproconazole were mixed in scope and all show synergistic effect at 39: 1 to 1: 39, especially when the two proportioning is during at 8: 1 to 1: 4, synergistic effect is more obviously outstanding, wherein when fluorine bacterium azoles and cyproconazole weight ratio are 2: 1, synergy ratio SR is maximum, and synergistic effect is the most obvious.
Application Example hexafluoro bacterium azoles and alkene azoles alcohol and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is in Jingyang County, Shaanxi Province, and test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 12.5% alkene azoles alcohol wetting powder (commercial).
The investigation alternaria leaf spot of apple state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 5 fluorine bacterium azoles, alkene azoles alcohol and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 5, after fluorine bacterium azoles and alkene azoles alcohol are composite, can effectively prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example seven fluorine bacterium azoles and triazolone and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This experimental establishment is in Weinan City Dali County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 25% trazodone wettable powder (commercial).
Investigation wheat powdery mildew disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 6 fluorine bacterium azoles, triazolone and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 6, after fluorine bacterium azoles and triazolone are composite, can effectively prevent and treat wheat powdery mildew, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example octafluoro bacterium azoles and Flusilazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in suburb, Chang'an county, Shaanxi Province, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 400 grams per liter Flusilazoles (commercial).
The investigation powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after dispenser 7 days, 14 days for the third time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 7 fluorine bacterium azoles, Flusilazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 7, after fluorine bacterium azoles and Flusilazole are composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example nine fluorine bacterium azoles and cyproconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 30% triflumizole wettable powder (commercial), 40% cyproconazole wetting powder (commercial).
Investigation pear scab disease index before medicine, in their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, within after dispenser 7 days, 14 days for the second time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 8 fluorine bacterium azoles, cyproconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 8, after fluorine bacterium azoles and cyproconazole are composite, can effectively prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (5)
1. a bactericidal composition that contains fluorine bacterium azoles and triazole class compounds, is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 2 ~ 78 ︰ 2 ~ 78, and described A component is fluorine bacterium azoles, and B is selected from Flusilazole.
2. contain according to claim 1 the bactericidal composition of fluorine bacterium azoles and triazole class compounds, it is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 5 ~ 65 ︰ 5 ~ 65.
3. contain according to claim 2 the bactericidal composition of fluorine bacterium azoles and triazole class compounds, it is characterized in that: the ratio of weight and number of fluorine bacterium azoles and Flusilazole is 10 ~ 35 ︰ 10 ~ 35.
4. contain according to claim 1 the bactericidal composition of fluorine bacterium azoles and triazole class compounds, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
5. contain according to claim 1 the bactericidal composition of fluorine bacterium azoles and triazole class compounds, it is characterized in that: bactericidal composition is used for preventing and treating Basidiomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny.
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| CN109953028A (en) * | 2017-12-25 | 2019-07-02 | 江苏托球农化股份有限公司 | A kind of olefin conversion wettable powder and preparation method thereof |
| CN111937890A (en) * | 2020-09-14 | 2020-11-17 | 宁波三江益农化学有限公司 | Sterilization composition containing prothioconazole and triflumizole |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101601388A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | A kind of bactericidal composition that contains Flutriafol and fluorine bacterium azoles |
| CN101601389A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | The bactericidal composition of a kind of fluorine-containing bacterium azoles and Difenoconazole |
| CN101617669A (en) * | 2009-07-28 | 2010-01-06 | 陕西汤普森生物科技有限公司 | Sterilization composite containing triflumizole and tebuconazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601388A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | A kind of bactericidal composition that contains Flutriafol and fluorine bacterium azoles |
| CN101601389A (en) * | 2009-07-20 | 2009-12-16 | 陕西汤普森生物科技有限公司 | The bactericidal composition of a kind of fluorine-containing bacterium azoles and Difenoconazole |
| CN101617669A (en) * | 2009-07-28 | 2010-01-06 | 陕西汤普森生物科技有限公司 | Sterilization composite containing triflumizole and tebuconazole |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Applicant after: Shaanxi Welch Crop Protection Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shaanxi Welch Crop Protection Co., Ltd. |
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