CN103168786B - Ternary compound bactericidal composition and application thereof - Google Patents
Ternary compound bactericidal composition and application thereof Download PDFInfo
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Abstract
The invention relates to a ternary compound bactericidal composition and application thereof. The ternary compound bactericidal composition is composed of an active ingredient and a pesticide preparation auxiliary component, wherein the active ingredient is formed by compounding pyraclostrobin, metconazole and carbendazim together in a weight ratio of (0.05-1): (0.05-1.5): 1; and the pesticide preparation auxiliary component comprises compound sodium nitrophenolate accounting for 0.05-2% of the composition in mass percent. The ternary compound bactericidal composition is formed by compounding pyraclostrobin, metconazole and carbendazim together in a special ratio, thereby achieving very obvious synergistic interaction effect; and provided by lots of experiments, after compounding, toxicity on the mammal is not increased. Besides, the applicant further finds out the compounding effect of pyraclostrobin, metconazole and carbendazim can be further promoted in the special form of wetting dispersant and wetting dispersing agent according to the invention; and therefore, the synergistic effect of the three ingredients is developed to an utmost extent.
Description
Technical field
The invention belongs to pesticide field, particularly a kind of ternary built bactericidal composition and application thereof.
Background technology
Pyraclostrobin is New-type wide-spectrum bactericide.The mechanism of action: be mitochondrial respiratory inhibitor. by stoping electronics to shift in cytochrome b cl is synthetic.There is protection, treatment, blade infiltration conduction.Pyraclostrobin missible oil shows that through field control effectiveness test result powdery mildew of cucumber, downy mildew and banana freckle, leaf spot are had to good control efficiency.
Carbendazim (english common name carbendazim), chemical name: N-(2-benzimidazole base)-methyl carbamate, is high-efficiency low-toxicity systemic fungicide, has interior suction treatment and protective effect.By disturbing the formation of spindle in pathogen mitosis, affect cell division, play bactericidal action.Carbendazim is a kind of broad-spectrum germicide, and the disease that various crop is caused by fungi (as imperfect fungus, many sac fungis) has control efficiency.Can be used for foliar spray, seed treatment and soil treatment etc.Control cucurbits powdery mildew, tomato fusarium wilt, beans anthracnose, control brassicaceous vegetable, shallot, leek gray mold etc.
Metconazole is C-14 demethylation enzyme inhibitor in a kind of ergosterol biosynthesis.Although the mechanism of action is the same with other triazole bactericidal agents, activity profile difference is larger.Two kinds of isomer have bactericidal activity, but cis activity is higher than trans.The antifungal spectrum of metconazole is very extensive, and active splendid.Metconazole field is used and cereal septoria musiva, fusarium and handle rest fungus are planted to disease is had remarkable effect.Metconazole is compared with traditional bactericide, and dosage is extremely low and prevent and treat cereal to plant disease scope very wide.
The open CN102017971A of Chinese invention patent discloses a kind of bactericidal composition that contains metconazole, wherein disclose metconazole and carbendazim have been carried out to the composite effect that can obtain Synergistic according to weight fraction than 1～80:80～1, in practical application, can reach reduction resistance, expand the object of fungicidal spectrum and reduction use cost.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of new bactericidal composition, and it can expect to have better control efficiency, lower resistance and lower use cost.
For solving above technical problem, the technical solution adopted in the present invention is as follows:
A kind of ternary built bactericidal composition, it is made up of active component and pesticidal preparations auxiliary element, particularly, active component is formed by weight 0.05～1:0.05～1.5:1 is composite by pyraclostrobin, metconazole and carbendazim, and described pesticidal preparations auxiliary element includes and accounts for the compound sodium nitrophenolate that the quality percentage composition of composition is 0.05%～2%.
Preferably, described active component is formed by weight 0.1～1:0.1～1:1 is composite by pyraclostrobin, metconazole and carbendazim.More preferably, active component is formed by weight 0.2～0.5:0.2～0.5:1 is composite by pyraclostrobin, metconazole and carbendazim.In the time that three kinds of compositions are composite according to this ratio, not only reach the most significant synergistic effect, and toxicity minimum to people and animals and environment.
According to the present invention, bactericidal composition can be made acceptable formulation in any agricultural, and preferably green pesticide form, as water dispersible granules, suspending agent.
According to a concrete aspect of the present invention, the formulation of described ternary built bactericidal composition is water dispersible granules, in weight percentage, it is composed as follows: active component 5%～90%, dispersion moisture agent 2%～20%, disintegrant 0.5%～5%, binding agent 1%～10%, compound sodium nitrophenolate 0.05%～2% and filler surplus.
When bactericidal composition is water dispersible granules, the weight content that active component preferably accounts for described bactericidal composition is 15%～80%.
In water dispersible granules, dispersion moisture agent is preferably made up of by weight 1:0.5～15 polyoxyethylene carboxylate and alkylnaphthalene sulfonate.
In water dispersible granules, disintegrant can be for being selected from one or several in crospolyvinylpyrrolidone, crosslinked carboxymethyl fecula sodium, low-substituted hydroxypropyl cellulose, Ac-Di-Sol, ammonium sulfate, magnesium chloride, aluminium chloride, urea, anhydrous sodium sulfate, polyethyl acrylate and calcium chloride.
In water dispersible granules, the selection of binding agent and filler is not particularly limited, and can be conventional those in this area.For example, binding agent can be starch, dextrin, gum Arabic, soybean protein, sodium silicate, gypsum, polyvinyl alcohol, polyvinyl acetate, ethene-vinyl acetate copolymer resins etc.Filler can be calcite, clay, kaolin, talcum, quicklime, diatomite, atlapulgite, mineral salt, diatomite, bentonite, white carbon, silica gel etc.
A preparation process of water dispersible granules is as follows: first by the pyraclostrobin of formula ratio, carbendazim, metconazole, dispersion moisture agent, disintegrant, compound sodium nitrophenolate, filler premixed, mixed material mixes again, then pulverize through airslide disintegrating mill, material after pulverizing is proceeded in kneader, add water and the kneading of formula ratio binding agent, extruder grain, is drying to obtain.
According to another concrete aspect of the present invention, the formulation of ternary built bactericidal composition is suspending agent, in weight percentage, it is composed as follows: active component 5%～90%, wetting dispersing agent 2%～15%, thickener 0.5%～5%, antifreezing agent 1%～10%, compound sodium nitrophenolate 0.05%～2% and deionized water surplus.
In suspending agent, described wetting dispersing agent is preferably made up of by weight 1:1～20 polycarboxylate and lignosulfonates.
In suspending agent, described thickener is preferably made up of by weight 1:2～20 carboxymethyl cellulose and Magnesiumaluminumsilicate.
In suspending agent, antifreezing agent can be for being selected from one or several in isopropyl alcohol, ethylene glycol, glycerine, diethylene glycol (DEG), butyl glycol ether, propandiol butyl ether, acetate, calcium chloride, sodium acetate and magnesium chloride.
A preparation process of suspending agent is as follows: the pyraclostrobin of formula ratio, metconazole, carbendazim, wetting dispersing agent, thickener, compound sodium nitrophenolate, antifreezing agent and deionized water are mixed, adopt high-speed shearing machine to carry out just pulverizing, then proceed in serialization sand mill and grind, make 95% above material particular diameter below 7 μ m, to obtain final product.
Composition of the present invention, for the control efficiency that on fruit tree, vegetables and cereal crop there has been Common Diseases, particularly has the control efficiency of highly significant to leaf spot, downy mildew, the brown spot of fruit tree for example apple tree, cereal crop for example soybean, corn.For this reason, the present invention is also particularly related to above-mentioned composition pesticide in the application preventing and treating in the leaf spot of fruit tree, vegetables and cereal crop, downy mildew, brown spot.
Owing to adopting above technical scheme, the present invention compared with prior art tool has the following advantages:
The present invention is by composite according to special ratios to pyraclostrobin, metconazole and carbendazim, and add the compound sodium nitrophenolate of specified quantitative, obtain the synergistic function of highly significant, compare the further fungicidal spectrum that expanded with the binary built of carbendazim and metconazole, the disease such as brown spot, leaf spot of fruit tree, vegetables and cereal crop is had to special efficacy.In addition,, through experimental results demonstrate, composite do not have increase afterwards to mammalian toxicity.The further discovery of applicant can further promote the composite effect of active component by specific wetting dispersing agent and dispersion moisture agent, allow to bring into play to the full extent synergistic effect.
Embodiment
Embodiment 1 55% pyraclostrobin metconazole carbendazim water dispersing granule
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crospolyvinylpyrrolidone and low replacement CMC (weight ratio 2:1), and binding agent is starch, and filler is diatomite.
Water dispersible granules preparation method is as follows: by filling a prescription the each material premixed except binding agent, mixing again, pulverizes through airslide disintegrating mill, then proceeds in kneader and add water and binding agent kneading, and extruder grain, dry, to obtain final product.
The technical indicator of water dispersible granules is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 2 70% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is Ac-Di-Sol, and binding agent is dextrin, and filler is kaolin.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 3 60% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is low-substituted hydroxypropyl cellulose, and binding agent is dextrin, and filler is bentonite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 4 30% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crosslinked carboxymethyl fecula sodium and low-substituted hydroxypropyl cellulose, and binding agent is gum Arabic, and filler is attapulgite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 5 40% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crosslinked carboxymethyl fecula sodium and low-substituted hydroxypropyl cellulose (weight ratio 1.5:2), and binding agent is gum Arabic, and filler is attapulgite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=88% of 54 ± 2 DEG C of heat storages.
Embodiment 6 20% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crosslinked carboxymethyl fecula sodium and low-substituted hydroxypropyl cellulose (weight ratio 1.5:2), and binding agent is gum Arabic, and filler is attapulgite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤25ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 7 35% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crosslinked carboxymethyl fecula sodium and low-substituted hydroxypropyl cellulose (weight ratio 1:2), and binding agent is polyvinyl acetate, and filler is attapulgite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤30ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
Embodiment 8 30% pyraclostrobin metconazole carbendazim water dispersing granules
The composition of raw materials of water dispersible granules is referring to table 1, and wherein disintegrant is crosslinked carboxymethyl fecula sodium and low-substituted hydroxypropyl cellulose (weight ratio 1:1), and binding agent is starch, and filler is diatomite.
Water dispersible granules preparation method is with embodiment 1, and technical indicator is as follows: suspensibility >=90%; Disintegration time≤45s; Wetting time≤60s; Moisture≤2.5%; PH value 6.0～9.0; Dispersed >=85%; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤30ml; Particle size range (0.8mm～1.5mm) >=97%; 2 weeks rear suspensibility >=85% of 54 ± 2 DEG C of heat storages.
The composition of raw materials of table 1 embodiment 1～8 pyraclostrobin metconazole carbendazim water dispersing granule
Embodiment 9 35% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.3:3), and antifreezing agent is ethylene glycol.
The preparation method of suspending agent is as follows: by formula, each raw material is joined in sand cylinder, after stirring, use again high-speed shearing machine pre-dispersed, then proceed to sand mill sand milling, add sand milling medium zirconium oxide bead, start sand milling, make the average grain diameter of material below 3 μ m, after 5 hours, stop sand milling, filter, remove zirconium oxide bead, to obtain final product.
The technical indicator of suspending agent is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 10 40% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.3:3), and antifreezing agent is diethylene glycol (DEG).
The preparation method of suspending agent is with embodiment 9, and gained suspending agent technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 11 25% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.3:3), and antifreezing agent is propandiol butyl ether.
The preparation method of suspending agent is with embodiment 9, and technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 12 45% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.1:3), and antifreezing agent is glycerine.
The preparation method of suspending agent is with example 9, and technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 13 60% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.4:2), and antifreezing agent is sodium acetate.
The preparation method of suspending agent is with example 9, and technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 14 45% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.3:4.5), and antifreezing agent is butyl glycol ether.
The preparation method of suspending agent is with example 9, and technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
Embodiment 15 60% pyraclostrobin metconazole carbendazim suspending agents
The composition of raw materials of suspending agent is referring to table 2, and wherein thickener is carboxymethyl cellulose and Magnesiumaluminumsilicate (weight ratio is 0.2:3), and antifreezing agent is glycerine.
The preparation method of suspending agent is with example 9, and technical indicator is as follows: suspensibility >=95%; PH value 6.0～8.0; Screen analysis (by 75 μ m hole sizers) >=98%; Lasting foaming characteristic (after 1min)≤20ml; Pourability: topple over rear residue≤3.0%, residue≤0.5% after washing; 54 ± 2 DEG C of heat are store suspensibility >=90% after 14 days; 0 ± 2 DEG C of cold storage suspensibility >=90% after 7 days.
The composition of raw materials of table 2 embodiment 9～15 pyraclostrobin metconazole carbendazim suspending agents
the Toxicity Determination of ternary built bactericidal composition to cercospora leaf spot
1. indoor pot biologically active
Test adopts seedling inoculation test method to measure, and trial crops soybean is cultured to 4 true leaves in greenhouse, carries out foliar spray processing by design flow on crops sprayer.The spore suspension for examination pathogen of cultivating on inoculation potato agar medium for 24 hours after chemicals treatment, postvaccinal test material is positioned in phytotron to be cultivated.In the time that the blank of not dispenser is fully fallen ill, carry out result investigation, disease scale also calculates preventive effect, does regression analysis according to each drug concentration numerical value and corresponding control probability value, calculates the EC of each medicament
50value, disease scale standard, preventive effect computational methods, EC
50value calculating method is with reference to National Standard of the People's Republic of China.
Control efficiency is scaled to probability value (y), and drug concentration (μ g/mL) is converted to logarithm value (x), calculates concentration EC in virulence equation and inhibition with method of least squares
50, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
CTC≤80 represent that composition performance is for antagonism; As 80 < CTC < 120, represent that said composition shows as addition; When CTC >=120, represent that said composition shows as synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) × 100
The percentage composition of C in percentage composition+C medicament toxicity index × mixture of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture.
Co-toxicity coefficient (CTC)=[actual measurement toxicity index (ATI)/theoretical toxicity index (TTI)] × 100.
Result of the test is referring to table 3.Result shows, the composite bactericidal composition of pyraclostrobin metconazole carbendazim three components, and to having very excellent control efficiency for examination target, the potted plant biologically active of three component mixtures, apparently higher than single dose and two component built agents thereof, the results are shown in example 1
Table 3
field control effectiveness test
The pyraclostrobin metconazole carbendazim composite germicide control field apple tree brown spot test of pesticide effectiveness
This experimental establishment is carried out in suburb, Lianshui County, Jiangsu Province, contrast medicament 40% carbendazim SC (commercially available), and 25% pyraclostrobin SC, 15% metconazole WP and other enforcement medicament are researched and developed by Jiangsu Qizhou Green Chemical Co., Ltd, provide.
The investigation apple tree brown spot state of an illness before medication, in the dispenser for the first time of state of an illness initial stage, dispenser in every 10 days once, is executed 2 times altogether.After dispenser 7 days for the second time, 14 days, within 28 days, investigate respectively apple tree brown spot disease index and calculate preventive effect.Experimental result is as shown in table 4.
Table 4
As can be seen from Table 4, energy effectively preventing and treating apple-tree brown spot after pyraclostrobin metconazole carbendazim is composite, control efficiency is all much better than contrast agents, in the scope of application, target crop is had no adverse effects.
The present invention, owing to adopting above-mentioned formula, can produce higher synergistic function.Because carbendazim uses for many years, pesticide resistance is obvious, and action effect is poor.Compared with single dose pyraclostrobin or metconazole or carbendazim control corps diseases, expand and prevented and treated disease scope, delay drug-fast generation.Obviously improve drug effect; dosage and the spraying times of every mu of use are reduced; because carbendazim price is relatively cheap; the agricultural cost of medicament after composite is starkly lower than the agriculture basis of pyraclostrobin and metconazole list preparation; after composite, alleviate peasant burden; promote peasant's increasing both production and income, ensured better agriculture safety in production and protected ecotope.Be applied to agricultural plant chemoproection field, to fruit tree, the leaf spot of the cereal crops such as soybean, corn, downy mildew, the harm of brown spot germ have excellence, protection and therapeutic action efficiently.
toxicity test
Determine that in Toxicity Determination test and field control effectiveness test composition has crop downy mildew, brown spot, leaf spot on the basis of excellent preventive effect, has carried out acute toxicity detection.Result is referring to table 5.
Table 5 toxicity test result
As can be seen from Table 5, after pyraclostrobin and metconazole, carbendazim are composite, in the scope of application, target crop is had no adverse effects, its toxicity for honeybee and single dose indifference, for the toxicity indifference of Japanese quail, due to the setting of test dose, belong to low toxicity, for the toxicity of rat, complex preparation toxicity rank all belongs to low toxicity or micro-poison.For the toxicity of trout, composite rear toxicity is starkly lower than single dose carbendazim, belongs to low toxicity rank.Toxicity test shows, the present invention is by pyraclostrobin and metconazole, the composite increase that does not cause toxicity of carbendazim.If consider medicament to multiple mammiferous toxicity, bactericidal composition of the present invention is all superior than single dose, Risk Reduction.
Above-described embodiment is only explanation technical conceive of the present invention and feature; its object is to allow person skilled in the art can understand content of the present invention and implement according to this; can not limit the scope of the invention with this; all equivalences that Spirit Essence is done according to the present invention change or modify, within all should being encompassed in protection scope of the present invention.
Claims (6)
1. a ternary built bactericidal composition is in the application preventing and treating in apple marssonina leaf spot, described ternary built bactericidal composition is made up of active component and pesticidal preparations auxiliary element, it is characterized in that: the formulation of described ternary built bactericidal composition is water dispersible granules, in weight percentage, it is composed as follows: active component 5%～90%, dispersion moisture agent 2%～20%, disintegrant 0.5%～5%, binding agent 1%～10%, compound sodium nitrophenolate 0.05%～2% and filler surplus, described active component is by pyraclostrobin, metconazole and carbendazim form by weight 0.05～1:0.05～1.5:1 is composite, described dispersion moisture agent is made up of by weight 1:0.5～15 polyoxyethylene carboxylate and alkylnaphthalene sulfonate.
2. application according to claim 1, is characterized in that: described active component is formed by weight 0.1～1:0.1～1:1 is composite by pyraclostrobin, metconazole and carbendazim.
3. application according to claim 2, is characterized in that: described active component is formed by weight 0.2～0.5:0.2～0.5:1 is composite by pyraclostrobin, metconazole and carbendazim.
4. a ternary built bactericidal composition is in the application preventing and treating in apple marssonina leaf spot, described ternary built bactericidal composition is made up of active component and pesticidal preparations auxiliary element, it is characterized in that: the formulation of described ternary built bactericidal composition is suspending agent, in weight percentage, it is composed as follows: active component 5%～90%, wetting dispersing agent 2%～15%, thickener 0.5%～5%, antifreezing agent 1%～10%, compound sodium nitrophenolate 0.05%～2% and deionized water surplus, described active component is by pyraclostrobin, metconazole and carbendazim form by weight 0.05～1:0.05～1.5:1 is composite, described wetting dispersing agent is made up of by weight 1:1～20 polycarboxylate and lignosulfonates, described thickener is made up of by weight 1:2～20 carboxymethyl cellulose and Magnesiumaluminumsilicate.
5. application according to claim 4, is characterized in that: described active component is formed by weight 0.1～1:0.1～1:1 is composite by pyraclostrobin, metconazole and carbendazim.
6. application according to claim 5, is characterized in that: described active component is formed by weight 0.2～0.5:0.2～0.5:1 is composite by pyraclostrobin, metconazole and carbendazim.
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| CN103960264B (en) * | 2014-05-05 | 2015-07-01 | 河北双吉化工有限公司 | Bactericidal composition containing pyraclostrobin, mancozeb and compound sodium nitrophenolate |
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