CN102065941A - 吸入器 - Google Patents
吸入器 Download PDFInfo
- Publication number
- CN102065941A CN102065941A CN2009801233364A CN200980123336A CN102065941A CN 102065941 A CN102065941 A CN 102065941A CN 2009801233364 A CN2009801233364 A CN 2009801233364A CN 200980123336 A CN200980123336 A CN 200980123336A CN 102065941 A CN102065941 A CN 102065941A
- Authority
- CN
- China
- Prior art keywords
- inhaler
- amino
- phenyl
- quinazoline
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- -1 EGFR inhibitors Substances 0.000 description 114
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 90
- 150000003839 salts Chemical class 0.000 description 25
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 24
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 16
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 239000013583 drug formulation Substances 0.000 description 13
- 229910019142 PO4 Inorganic materials 0.000 description 10
- 239000013543 active substance Substances 0.000 description 10
- 230000003454 betamimetic effect Effects 0.000 description 10
- 235000021317 phosphate Nutrition 0.000 description 10
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 10
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 9
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- 239000005557 antagonist Substances 0.000 description 9
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 9
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 9
- CXYRUNPLKGGUJF-RAFJPFSSSA-M scopolamine methobromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)C)=CC=CC=C1 CXYRUNPLKGGUJF-RAFJPFSSSA-M 0.000 description 9
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- 229910002651 NO3 Inorganic materials 0.000 description 8
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 8
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- 239000008194 pharmaceutical composition Substances 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 8
- 239000010452 phosphate Substances 0.000 description 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 8
- 229940095064 tartrate Drugs 0.000 description 8
- 239000002585 base Substances 0.000 description 7
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 6
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 description 6
- 150000004677 hydrates Chemical class 0.000 description 6
- YEESKJGWJFYOOK-IJHYULJSSA-N leukotriene D4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@H](N)C(=O)NCC(O)=O YEESKJGWJFYOOK-IJHYULJSSA-N 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
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- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 6
- 150000001242 acetic acid derivatives Chemical class 0.000 description 5
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- 150000003842 bromide salts Chemical class 0.000 description 5
- 239000003246 corticosteroid Substances 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 description 4
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- 229960001334 corticosteroids Drugs 0.000 description 4
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- 238000002360 preparation method Methods 0.000 description 4
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000001649 bromium compounds Chemical class 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 2
- ZMPRRFPMMJQXPP-UHFFFAOYSA-N 2-sulfobenzoic acid Chemical class OC(=O)C1=CC=CC=C1S(O)(=O)=O ZMPRRFPMMJQXPP-UHFFFAOYSA-N 0.000 description 2
- ULMFXAMQUGLVGA-LJQANCHMSA-N 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-n-[(2r)-4,4,4-trifluoro-2-methylbutyl]indole-5-carboxamide Chemical compound C=1C=C(CC=2C3=CC(=CC=C3N(C)C=2)C(=O)NC[C@H](C)CC(F)(F)F)C(OC)=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C ULMFXAMQUGLVGA-LJQANCHMSA-N 0.000 description 2
- CVDXFPBVOIERBH-JWQCQUIFSA-N 4-[(4ar,10bs)-9-ethoxy-8-methoxy-2-methyl-3,4,4a,10b-tetrahydro-1h-benzo[c][1,6]naphthyridin-6-yl]-n,n-di(propan-2-yl)benzamide Chemical compound N([C@@H]1CCN(C)C[C@@H]1C=1C=C(C(=CC=11)OC)OCC)=C1C1=CC=C(C(=O)N(C(C)C)C(C)C)C=C1 CVDXFPBVOIERBH-JWQCQUIFSA-N 0.000 description 2
- PYUGFOWNYMLROI-KPKJPENVSA-N 8-[(e)-2-[4-[4-(4-fluorophenyl)butoxy]phenyl]ethenyl]-2-(2h-tetrazol-5-yl)chromen-4-one Chemical compound C1=CC(F)=CC=C1CCCCOC(C=C1)=CC=C1\C=C\C1=CC=CC2=C1OC(C=1NN=NN=1)=CC2=O PYUGFOWNYMLROI-KPKJPENVSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000000808 adrenergic beta-agonist Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000001078 anti-cholinergic effect Effects 0.000 description 2
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 2
- 229940125715 antihistaminic agent Drugs 0.000 description 2
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- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 description 2
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- OATDVDIMNNZTEY-DAXLTYESSA-N flutropium Chemical compound C[N@@+]1(CCF)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1 OATDVDIMNNZTEY-DAXLTYESSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 2
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- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- FSDOTMQXIKBFKJ-UHFFFAOYSA-N n-(2,5-dichloropyridin-3-yl)-8-methoxyquinoline-5-carboxamide Chemical compound C12=CC=CN=C2C(OC)=CC=C1C(=O)NC1=CC(Cl)=CN=C1Cl FSDOTMQXIKBFKJ-UHFFFAOYSA-N 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
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- 159000000001 potassium salts Chemical class 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
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- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
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- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 description 1
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 description 1
- PVLJETXTTWAYEW-UHFFFAOYSA-N Mizolastine Chemical compound N=1C=CC(=O)NC=1N(C)C(CC1)CCN1C1=NC2=CC=CC=C2N1CC1=CC=C(F)C=C1 PVLJETXTTWAYEW-UHFFFAOYSA-N 0.000 description 1
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 description 1
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- 229950010090 pumafentrine Drugs 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
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- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
- 229960001634 ritodrine Drugs 0.000 description 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 description 1
- 229960002586 roflumilast Drugs 0.000 description 1
- 229960001879 ropinirole Drugs 0.000 description 1
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 1
- 229950000366 roxindole Drugs 0.000 description 1
- BKTTWZADZNUOBW-UHFFFAOYSA-N roxindole Chemical compound C=12[CH]C(O)=CC=C2N=CC=1CCCCN(CC=1)CCC=1C1=CC=CC=C1 BKTTWZADZNUOBW-UHFFFAOYSA-N 0.000 description 1
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- 125000006850 spacer group Chemical group 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
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- 229960004764 zafirlukast Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
- B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
- B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
- B05B11/1004—Piston pumps comprising a movable cylinder and a stationary piston
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
- B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Nozzles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08011228.7 | 2008-06-20 | ||
| EP08011228A EP2135632A1 (de) | 2008-06-20 | 2008-06-20 | Inhalator |
| PCT/EP2009/004435 WO2009153049A1 (en) | 2008-06-20 | 2009-06-19 | Inhaler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102065941A true CN102065941A (zh) | 2011-05-18 |
Family
ID=39925072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801233364A Pending CN102065941A (zh) | 2008-06-20 | 2009-06-19 | 吸入器 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20090314287A1 (https=) |
| EP (2) | EP2135632A1 (https=) |
| JP (1) | JP5719291B2 (https=) |
| KR (1) | KR20110028513A (https=) |
| CN (1) | CN102065941A (https=) |
| AR (1) | AR072215A1 (https=) |
| AU (1) | AU2009259631A1 (https=) |
| BR (1) | BRPI0914817A2 (https=) |
| CA (1) | CA2728044C (https=) |
| CL (1) | CL2010001482A1 (https=) |
| CO (1) | CO6280506A2 (https=) |
| DK (1) | DK2326374T3 (https=) |
| EA (1) | EA201100026A1 (https=) |
| EC (1) | ECSP10010728A (https=) |
| ES (1) | ES2787252T3 (https=) |
| IL (1) | IL209233A (https=) |
| MA (1) | MA32402B1 (https=) |
| MX (1) | MX2010013429A (https=) |
| NZ (1) | NZ589928A (https=) |
| PE (1) | PE20110034A1 (https=) |
| SG (1) | SG193869A1 (https=) |
| TW (1) | TW201004663A (https=) |
| UA (1) | UA103028C2 (https=) |
| UY (1) | UY31915A (https=) |
| WO (1) | WO2009153049A1 (https=) |
| ZA (1) | ZA201007973B (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104755122A (zh) * | 2012-06-14 | 2015-07-01 | 3M创新有限公司 | 定量分配阀 |
| CN106983937A (zh) * | 2017-05-10 | 2017-07-28 | 深圳市立德瑞光电科技有限公司 | 雾化给药装置 |
| TWI704014B (zh) * | 2018-09-10 | 2020-09-11 | 微邦科技股份有限公司 | 吸入器吹嘴和吸入器 |
| TWI839407B (zh) * | 2018-11-09 | 2024-04-21 | 比利時商索芙特海爾公司 | 藥筒及其保持器、吸入設備、提供壓力補償的方法 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| EP2414560B1 (de) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Verfahren zur beschichtung einer oberfläche eines bauteils |
| JP5763053B2 (ja) | 2009-05-18 | 2015-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アダプタ、吸入器具及びアトマイザ |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| BR112012012475B1 (pt) | 2009-11-25 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Nebulizador |
| WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| GB201113662D0 (en) * | 2011-08-08 | 2011-09-21 | Prosonix Ltd | Pharmaceutical compositions |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| CN116036425A (zh) | 2014-05-07 | 2023-05-02 | 勃林格殷格翰国际有限公司 | 喷雾器、指示器装置及容器 |
| WO2015169430A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
| IL247927B (en) | 2014-05-07 | 2022-09-01 | Boehringer Ingelheim Int | Container, a device that turns a liquid into a fine spray and use |
| AU2019285374A1 (en) * | 2018-06-13 | 2021-01-28 | Puff-Ah Pty Ltd | Apparatus for use in delivering respiratory drugs |
| JP7444047B2 (ja) * | 2020-12-21 | 2024-03-06 | オムロンヘルスケア株式会社 | ネブライザキット及びネブライザ |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001078818A2 (en) * | 2000-04-14 | 2001-10-25 | Trudell Medical International | Nasal inhaler |
| WO2004091704A1 (en) * | 2003-04-16 | 2004-10-28 | Trudell Medical International | Antistatic medication delivery apparatus |
| WO2005014175A1 (en) * | 2003-07-16 | 2005-02-17 | Boehringer Ingelheim Microparts Gmbh | A process for producing microfluidic arrangements from a plate-shaped composite structure |
| WO2005079997A1 (de) * | 2004-02-24 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Zerstäuber |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8908647D0 (en) * | 1989-04-17 | 1989-06-01 | Glaxo Group Ltd | Device |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| SE9400257D0 (sv) * | 1994-01-27 | 1994-01-27 | Astra Ab | Spacer |
| US5848588A (en) * | 1994-05-25 | 1998-12-15 | Trudell Medical Group | Backpiece for receiving an MDI adapter in an aerosolization spacer |
| DE4428434A1 (de) * | 1994-08-11 | 1996-02-15 | Boehringer Ingelheim Kg | Verschlußkappe und Verfahren zur gasblasenfreien Füllung von Behältern |
| NZ293163A (en) * | 1994-09-21 | 1998-09-24 | Inhale Therapeutic Syst | Inhalation medicament disperser, aerosol from high pressure gas entrainment of fluidised powder drawn from receptacle feed tube |
| US5499750A (en) * | 1995-01-17 | 1996-03-19 | Manifold; William J. | Spraying device having a removable and replaceable bladder |
| AUPN417395A0 (en) * | 1995-07-14 | 1995-08-10 | Techbase Pty. Ltd. | An improved spacer |
| DE19536902A1 (de) * | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| DE19733651A1 (de) | 1997-08-04 | 1999-02-18 | Boehringer Ingelheim Pharma | Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole |
| ZA9811257B (en) * | 1998-12-09 | 2001-01-31 | App Sub Cipla Ltd 8 8 2000 | Inhalation device. |
| DE19940713A1 (de) | 1999-02-23 | 2001-03-01 | Boehringer Ingelheim Int | Kartusche für eine Flüssigkeit |
| DE29920790U1 (de) * | 1999-11-16 | 2000-05-18 | VWP Maschinenbau und Service GmbH, 03246 Crinitz | Einrichtung zum Vernebeln von Reagenzien zur inneren Applikation dieser Reagenzien |
| US6904908B2 (en) * | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
| CA2496882C (en) * | 2002-09-06 | 2011-11-01 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
| CN2871190Y (zh) * | 2005-11-17 | 2007-02-21 | 蔡明财 | 杆体 |
| EP1792660A1 (en) * | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| DE102006025884A1 (de) * | 2006-06-02 | 2007-12-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Adapter mit einem Anschluss für einen Zerstäuber |
| DE102006025871A1 (de) * | 2006-06-02 | 2007-12-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zerstäuber |
-
2008
- 2008-06-20 EP EP08011228A patent/EP2135632A1/de not_active Withdrawn
-
2009
- 2009-06-09 TW TW098119260A patent/TW201004663A/zh unknown
- 2009-06-18 UY UY0001031915A patent/UY31915A/es not_active Application Discontinuation
- 2009-06-19 MX MX2010013429A patent/MX2010013429A/es active IP Right Grant
- 2009-06-19 ES ES09765629T patent/ES2787252T3/es active Active
- 2009-06-19 UA UAA201100421A patent/UA103028C2/ru unknown
- 2009-06-19 KR KR1020117001462A patent/KR20110028513A/ko not_active Ceased
- 2009-06-19 CN CN2009801233364A patent/CN102065941A/zh active Pending
- 2009-06-19 JP JP2011513953A patent/JP5719291B2/ja active Active
- 2009-06-19 WO PCT/EP2009/004435 patent/WO2009153049A1/en not_active Ceased
- 2009-06-19 EP EP09765629.2A patent/EP2326374B1/en active Active
- 2009-06-19 BR BRPI0914817A patent/BRPI0914817A2/pt not_active IP Right Cessation
- 2009-06-19 AU AU2009259631A patent/AU2009259631A1/en not_active Abandoned
- 2009-06-19 US US12/487,840 patent/US20090314287A1/en not_active Abandoned
- 2009-06-19 NZ NZ589928A patent/NZ589928A/en not_active Application Discontinuation
- 2009-06-19 DK DK09765629.2T patent/DK2326374T3/da active
- 2009-06-19 SG SG2013067830A patent/SG193869A1/en unknown
- 2009-06-19 EA EA201100026A patent/EA201100026A1/ru unknown
- 2009-06-19 PE PE2010001165A patent/PE20110034A1/es not_active Application Discontinuation
- 2009-06-19 AR ARP090102256A patent/AR072215A1/es unknown
- 2009-06-19 CA CA2728044A patent/CA2728044C/en active Active
-
2010
- 2010-11-08 ZA ZA2010/07973A patent/ZA201007973B/en unknown
- 2010-11-10 IL IL209233A patent/IL209233A/en active IP Right Grant
- 2010-12-09 CO CO10154613A patent/CO6280506A2/es active IP Right Grant
- 2010-12-17 CL CL2010001482A patent/CL2010001482A1/es unknown
- 2010-12-20 MA MA33440A patent/MA32402B1/fr unknown
- 2010-12-29 EC EC2010010728A patent/ECSP10010728A/es unknown
Patent Citations (4)
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| WO2001078818A2 (en) * | 2000-04-14 | 2001-10-25 | Trudell Medical International | Nasal inhaler |
| WO2004091704A1 (en) * | 2003-04-16 | 2004-10-28 | Trudell Medical International | Antistatic medication delivery apparatus |
| WO2005014175A1 (en) * | 2003-07-16 | 2005-02-17 | Boehringer Ingelheim Microparts Gmbh | A process for producing microfluidic arrangements from a plate-shaped composite structure |
| WO2005079997A1 (de) * | 2004-02-24 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Zerstäuber |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104755122A (zh) * | 2012-06-14 | 2015-07-01 | 3M创新有限公司 | 定量分配阀 |
| CN104755122B (zh) * | 2012-06-14 | 2018-09-28 | 3M创新有限公司 | 定量分配阀 |
| CN106983937A (zh) * | 2017-05-10 | 2017-07-28 | 深圳市立德瑞光电科技有限公司 | 雾化给药装置 |
| TWI704014B (zh) * | 2018-09-10 | 2020-09-11 | 微邦科技股份有限公司 | 吸入器吹嘴和吸入器 |
| TWI839407B (zh) * | 2018-11-09 | 2024-04-21 | 比利時商索芙特海爾公司 | 藥筒及其保持器、吸入設備、提供壓力補償的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| UY31915A (es) | 2010-01-29 |
| UA103028C2 (ru) | 2013-09-10 |
| SG193869A1 (en) | 2013-10-30 |
| DK2326374T3 (da) | 2020-05-18 |
| ECSP10010728A (es) | 2011-02-28 |
| MX2010013429A (es) | 2010-12-21 |
| CA2728044C (en) | 2018-05-22 |
| AR072215A1 (es) | 2010-08-11 |
| ZA201007973B (en) | 2011-07-27 |
| PE20110034A1 (es) | 2011-02-09 |
| US20090314287A1 (en) | 2009-12-24 |
| KR20110028513A (ko) | 2011-03-18 |
| CL2010001482A1 (es) | 2011-09-02 |
| AU2009259631A1 (en) | 2009-12-23 |
| JP5719291B2 (ja) | 2015-05-13 |
| IL209233A (en) | 2013-10-31 |
| NZ589928A (en) | 2014-01-31 |
| EP2135632A1 (de) | 2009-12-23 |
| CO6280506A2 (es) | 2011-05-20 |
| WO2009153049A8 (en) | 2010-02-25 |
| EA201100026A1 (ru) | 2011-06-30 |
| BRPI0914817A2 (pt) | 2015-10-27 |
| EP2326374A1 (en) | 2011-06-01 |
| CA2728044A1 (en) | 2009-12-23 |
| WO2009153049A1 (en) | 2009-12-23 |
| IL209233A0 (en) | 2011-01-31 |
| JP2011524228A (ja) | 2011-09-01 |
| MA32402B1 (fr) | 2011-06-01 |
| EP2326374B1 (en) | 2020-03-04 |
| ES2787252T3 (es) | 2020-10-15 |
| TW201004663A (en) | 2010-02-01 |
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