CN102056901A - 二取代哌啶及其中间体的制备方法 - Google Patents
二取代哌啶及其中间体的制备方法 Download PDFInfo
- Publication number
- CN102056901A CN102056901A CN2008801067158A CN200880106715A CN102056901A CN 102056901 A CN102056901 A CN 102056901A CN 2008801067158 A CN2008801067158 A CN 2008801067158A CN 200880106715 A CN200880106715 A CN 200880106715A CN 102056901 A CN102056901 A CN 102056901A
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- CN
- China
- Prior art keywords
- compound
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- acid
- expression
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*([C@@](CCC(CN)=O)C(*)=O)C(C)=C Chemical compound C*([C@@](CCC(CN)=O)C(*)=O)C(C)=C 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0706449A FR2921060B1 (fr) | 2007-09-14 | 2007-09-14 | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
FR0706449 | 2007-09-14 | ||
PCT/FR2008/001280 WO2009090320A1 (fr) | 2007-09-14 | 2008-09-12 | Procede de preparation d'une piperidine disubstituee et intermediaires |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102056901A true CN102056901A (zh) | 2011-05-11 |
CN102056901B CN102056901B (zh) | 2014-09-03 |
Family
ID=39428023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880106715.8A Active CN102056901B (zh) | 2007-09-14 | 2008-09-12 | 二取代哌啶及其中间体的制备方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US8288553B2 (zh) |
EP (1) | EP2200983B1 (zh) |
JP (1) | JP5421265B2 (zh) |
CN (1) | CN102056901B (zh) |
AT (1) | ATE539057T1 (zh) |
CA (1) | CA2699438C (zh) |
ES (1) | ES2380098T3 (zh) |
FR (1) | FR2921060B1 (zh) |
HK (1) | HK1145324A1 (zh) |
WO (1) | WO2009090320A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103459372A (zh) * | 2011-03-31 | 2013-12-18 | 株式会社钟化 | 环状胺化合物的制造方法 |
CN104334559A (zh) * | 2012-05-30 | 2015-02-04 | 明治制果药业株式会社 | 新型β-内酰胺酶抑制剂及其制备方法 |
CN107540601A (zh) * | 2016-06-28 | 2018-01-05 | 新发药业有限公司 | 5r‑苄氧氨基哌啶‑2s‑甲酸酯及其草酸盐的便捷制备方法 |
CN107540600A (zh) * | 2016-06-28 | 2018-01-05 | 新发药业有限公司 | 一种阿维巴坦中间体生产废液的回收利用方法 |
WO2019033746A1 (zh) * | 2017-08-18 | 2019-02-21 | 新发药业有限公司 | 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法 |
CN109970625A (zh) * | 2017-12-28 | 2019-07-05 | 新发药业有限公司 | 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法 |
CN110498762A (zh) * | 2019-08-28 | 2019-11-26 | 齐鲁天和惠世制药有限公司 | 一种(2s,5r)-5-[(苄氧基)氨基]-哌啶-2-甲酸乙酯的合成方法 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
SG191320A1 (en) * | 2010-12-22 | 2013-07-31 | Meiji Seika Pharma Co Ltd | Optically-active diazabicyclooctane derivative and method for manufacturing same |
CN105294690B (zh) | 2011-06-17 | 2018-07-10 | 辉瑞抗感染公司 | 制备包括反-7-氧代-6-(磺基氧基)-1,6-二氮杂二环[3,2,1]辛烷-2-甲酰胺的杂环化合物及其盐的方法 |
US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
SG11201406120SA (en) | 2012-03-30 | 2014-10-30 | Cubist Pharm Inc | ISOXAZOLE β-LACTAMASE INHIBITORS |
US8969570B2 (en) | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
RU2014143821A (ru) | 2012-03-30 | 2016-05-27 | Кьюбист Фармасьютикалз, Инк. | 1, 3, 4-ОКСАДИАЗОЛЬНЫЕ И 1, 3, 4-ТИАДИАЗОЛЬНЫЕ ИНГИБИТОРЫ β-ЛАКТАМАЗЫ |
US8916709B2 (en) | 2012-03-30 | 2014-12-23 | Cubist Pharmaceuticals, Inc. | 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors |
UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
KR20170128641A (ko) | 2013-03-08 | 2017-11-22 | 욱크하르트 리미티드 | (2s,5r)-6-벤질옥시-7-옥소-1,6-디아자-비사이클로[3.2.1]옥탄-2-카복실산의 나트륨염 및 그 제조 |
US9120795B2 (en) | 2013-03-14 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | Crystalline form of a β-lactamase inhibitor |
TWI644908B (zh) | 2013-09-24 | 2018-12-21 | 明治製菓藥業股份有限公司 | 二氮雜二環辛烷衍生物之製法及其中間體 |
US9120796B2 (en) | 2013-10-02 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | B-lactamase inhibitor picoline salt |
EP3067355B1 (en) | 2013-10-08 | 2020-12-16 | Meiji Seika Pharma Co., Ltd. | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
JP6779787B2 (ja) | 2014-12-05 | 2020-11-04 | Meiji Seikaファルマ株式会社 | ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法 |
EP3411359B1 (en) * | 2016-02-04 | 2021-10-13 | Merck Sharp & Dohme Corp. | Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents |
CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
CN109956941B (zh) | 2017-12-25 | 2020-08-04 | 新发药业有限公司 | 一种阿维巴坦的简便制备方法 |
US20220194941A1 (en) * | 2019-04-26 | 2022-06-23 | Merck Sharp & Dohme Corp. | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-l,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE |
CN114989169A (zh) * | 2022-07-04 | 2022-09-02 | 哈药集团技术中心 | 一种阿维巴坦钠的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5059377A (zh) * | 1973-10-04 | 1975-05-22 | ||
JPS63162666A (ja) * | 1986-12-26 | 1988-07-06 | Asahi Chem Ind Co Ltd | アミノオキシ酢酸誘導体およびその製造方法 |
JPH0393762A (ja) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | 4‐ハロゲノ‐2‐アルコキシイミノ‐3‐オキソ脂肪酸の製造方法 |
FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
US6399793B1 (en) * | 2000-08-16 | 2002-06-04 | Bristol-Myers Squibb Company | Process for the preparation of α' chloroketones |
FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
US7439253B2 (en) * | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
JP3935126B2 (ja) * | 2003-09-24 | 2007-06-20 | 雅裕 亀田 | 装飾用灯具 |
US7396934B2 (en) * | 2003-11-17 | 2008-07-08 | Youssef El-Ahmad | Process for preparing 3-fluoroquinolines |
JP2007126358A (ja) * | 2004-01-20 | 2007-05-24 | Fujiyakuhin Co Ltd | フェニルアラニン誘導体 |
-
2007
- 2007-09-14 FR FR0706449A patent/FR2921060B1/fr active Active
-
2008
- 2008-09-12 US US12/677,741 patent/US8288553B2/en active Active
- 2008-09-12 ES ES08870986T patent/ES2380098T3/es active Active
- 2008-09-12 WO PCT/FR2008/001280 patent/WO2009090320A1/fr active Application Filing
- 2008-09-12 CA CA2699438A patent/CA2699438C/en active Active
- 2008-09-12 CN CN200880106715.8A patent/CN102056901B/zh active Active
- 2008-09-12 JP JP2010524543A patent/JP5421265B2/ja active Active
- 2008-09-12 AT AT08870986T patent/ATE539057T1/de active
- 2008-09-12 EP EP08870986A patent/EP2200983B1/fr active Active
-
2010
- 2010-12-16 HK HK10111791.6A patent/HK1145324A1/xx unknown
-
2012
- 2012-09-14 US US13/616,995 patent/US20130012712A1/en not_active Abandoned
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103459372A (zh) * | 2011-03-31 | 2013-12-18 | 株式会社钟化 | 环状胺化合物的制造方法 |
CN105859609B (zh) * | 2012-05-30 | 2019-04-09 | 明治制果药业株式会社 | β-内酰胺酶抑制剂及其制备方法 |
CN104334559A (zh) * | 2012-05-30 | 2015-02-04 | 明治制果药业株式会社 | 新型β-内酰胺酶抑制剂及其制备方法 |
CN105859609A (zh) * | 2012-05-30 | 2016-08-17 | 明治制果药业株式会社 | β-内酰胺酶抑制剂及其制备方法 |
TWI565707B (zh) * | 2012-05-30 | 2017-01-11 | 明治製菓藥業股份有限公司 | 新穎β-內醯胺酶抑制劑及其製造方法 |
CN104334559B (zh) * | 2012-05-30 | 2017-03-22 | 明治制果药业株式会社 | β‑内酰胺酶抑制剂及其制备方法 |
CN107540601B (zh) * | 2016-06-28 | 2019-07-19 | 新发药业有限公司 | 5r-苄氧氨基哌啶-2s-甲酸酯及其草酸盐的便捷制备方法 |
CN107540600A (zh) * | 2016-06-28 | 2018-01-05 | 新发药业有限公司 | 一种阿维巴坦中间体生产废液的回收利用方法 |
CN107540600B (zh) * | 2016-06-28 | 2019-07-09 | 新发药业有限公司 | 一种阿维巴坦中间体生产废液的回收利用方法 |
CN107540601A (zh) * | 2016-06-28 | 2018-01-05 | 新发药业有限公司 | 5r‑苄氧氨基哌啶‑2s‑甲酸酯及其草酸盐的便捷制备方法 |
WO2019033746A1 (zh) * | 2017-08-18 | 2019-02-21 | 新发药业有限公司 | 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法 |
CN109400521A (zh) * | 2017-08-18 | 2019-03-01 | 新发药业有限公司 | 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法 |
CN109400521B (zh) * | 2017-08-18 | 2020-05-08 | 新发药业有限公司 | 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法 |
AU2018317559B2 (en) * | 2017-08-18 | 2020-05-21 | Xinfa Pharmaceutical Co., Ltd | Improved method for preparation of 5R-benzyloxyaminopiperidine-2S-formate and an oxalate thereof |
CN109970625A (zh) * | 2017-12-28 | 2019-07-05 | 新发药业有限公司 | 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法 |
CN109970625B (zh) * | 2017-12-28 | 2021-02-26 | 新发药业有限公司 | 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法 |
CN110498762A (zh) * | 2019-08-28 | 2019-11-26 | 齐鲁天和惠世制药有限公司 | 一种(2s,5r)-5-[(苄氧基)氨基]-哌啶-2-甲酸乙酯的合成方法 |
CN110498762B (zh) * | 2019-08-28 | 2020-10-27 | 山东安信制药有限公司 | 一种(2s,5r)-5-[(苄氧基)氨基]-哌啶-2-甲酸乙酯的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
HK1145324A1 (en) | 2011-04-15 |
FR2921060B1 (fr) | 2012-06-15 |
US20130012712A1 (en) | 2013-01-10 |
US20100197928A1 (en) | 2010-08-05 |
ES2380098T3 (es) | 2012-05-08 |
JP5421265B2 (ja) | 2014-02-19 |
US8288553B2 (en) | 2012-10-16 |
CA2699438A1 (en) | 2009-07-23 |
WO2009090320A1 (fr) | 2009-07-23 |
EP2200983B1 (fr) | 2011-12-28 |
EP2200983A1 (fr) | 2010-06-30 |
CA2699438C (en) | 2016-11-22 |
CN102056901B (zh) | 2014-09-03 |
ATE539057T1 (de) | 2012-01-15 |
JP2010539147A (ja) | 2010-12-16 |
FR2921060A1 (fr) | 2009-03-20 |
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