CN102048653A - Amino acid type weak acid facial cleanser and preparation method thereof - Google Patents

Amino acid type weak acid facial cleanser and preparation method thereof Download PDF

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Publication number
CN102048653A
CN102048653A CN 201110001976 CN201110001976A CN102048653A CN 102048653 A CN102048653 A CN 102048653A CN 201110001976 CN201110001976 CN 201110001976 CN 201110001976 A CN201110001976 A CN 201110001976A CN 102048653 A CN102048653 A CN 102048653A
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China
Prior art keywords
amino acid
skin
facial cleaning
cleaning cream
pattern
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Granted
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CN 201110001976
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CN102048653B (en
Inventor
万宏雁
邓秀丽
黄必勇
陈子昂
李晓光
李韶雄
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Fujian Kehong biological engineering Limited by Share Ltd
Guangzhou Chemical Technology Co., Ltd.
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FUJIAN KEHONG BIOENGINEERING Co Ltd
GUANGZHOU YIFAN CHEMICAL CO Ltd
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Abstract

The invention discloses an amino acid type weak acid facial cleanser which comprises the following raw materials by weight percent: 15-40% of amino acid surfactant, 5-30% of moisturizer, 2-15% of emulsifier, 0-3% of thickener and the balance of deionized water. The invention further discloses a preparation method of the amino acid type weak acid facial cleanser. The amino acid type weak acid facial cleanser contains the full-natural amino acid surfactant and does not contain soap, and the pH value of the amino acid type weak acid facial cleanser is completely consistent with the average pH value of skin. The amino acid type weak acid facial cleanser can mildly remove various types of dirt, simultaneously maintain the weak acid environment of the skin, form a protective film on the surface layer of the skin, be excellent in skin affinity, avoid irritating the skin, rapidly recover the skin protective function after cleaning the skin, and enable the skin to realize oil-water balance and acid-base balance, thereby achieving the purpose of maintaining the health of the skin, being applicable to any skin type and being capable of being used for a long time.

Description

A kind of amino acid pattern faintly acid facial cleaning cream and preparation method thereof
Technical field
The present invention relates to the daily cosmetics technical field, relate in particular to a kind of have clean, the facial cleaning cream of skin-protecting function and preparation method thereof.
Background technology
As the daily cleaning cosmetic product, the performance quality of facial cleaning cream has very big influence to skin.The acid-base value of reason that skin is good and bad and skin and cosmetics (being pH value) has close contact.Human body skin surface is being owing to retaining acidic materials such as carbamide, uric acid, salinity, lactic acid, aminoacid, free fatty, so skin surface is faintly acid usually, and the pH value of healthy Asians's skin should be between 4.5~6.5.Skin only in its normal pH value scope, just is in faintly acid, just can make skin be in the optimum state that absorbs nutrition, and have the health status of the bests such as elasticity, gloss, moisture and resist extraneous erosive ability.
The weakly acidic condition of skin surface all has certain buffer capacity to acid, alkali, is called the neutralising capacity of skin.Wherein, skin is called deacidification to the cushioning effect of the acidic materials of pH value in 4.5~6.5 scopes; Skin is called the alkali neutralization to the cushioning effect of alkaline matter.When skin surface receives the stimulation of alkaline matter and when changing pH value, tart panniculus is also had the ability at short notice, original index is returned in the acid-base value adjustment of skin surface, this ability is called " the alkali neutralising capacity " of skin.Getting well with bad of skin, key are whether skin is healthy, and whether health is embodied on the alkali neutralising capacity of skin.Different people changes between 4.5~6.5 usually at the pH value of different times skin, also can exceed this scope sometimes.If outside 4.5~6.5, the alkali neutralising capacity of skin will weaken the skin pH value for a long time, skin matter will change, and finally causes the old and feeble and infringement of skin.Therefore, have only the corresponding skin care item of apolegamy, the skin pH value is remained between pH4.5~6.5, skin just can present optimum state, really reaches more beautiful, more healthy effect.
At present, the facial cleaning cream of prior art mostly is that pH value is usually more than 9.5 based on soap base class (fatty acid adds the alkali neutralization and forms).Clean product of this class has very strong cleaning effect, uses aftersensation very clean, used a period of time even after skin also can seem transparent.Yet the skin of this moment is not really to improve, but exfoliation excessively and hurt the illusion that skin produces.Cleaning effect is fine on this series products surface, but is in fact damaging skin silently, because its pH value is higher, so life-time service is understood injured skin unavoidably.For this reason, improve the performance of clean product comprehensively, when having clean surface functions such as the facial dust of removal, oils and fats, also have the effect of safeguarding skin health, being not only the skin protection method and the development trend of clean product science, also is the growing demands of consumers in general simultaneously.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art; provide a kind of contained for the All Pure Nature amino acid type surfactant, do not contain the amino acid pattern faintly acid facial cleaning cream of soap matter; when removing various dirt with gentleness; safeguard the weak acid environment of skin; and at skin surface formation protecting film, thereby reach the purpose of safeguarding skin health.Another object of the present invention is to provide the preparation method of above-mentioned amino acid pattern faintly acid facial cleaning cream.
Purpose of the present invention is achieved by the following technical programs:
A kind of amino acid pattern faintly acid facial cleaning cream provided by the invention, its raw material consists of by weight percentage: amino acid surfactant 15~40%, wetting agent 5~30%, emulsifying agent 2~15%, thickening agent 0~3%, surplus are deionized water.Preferably consist of: amino acid surfactant 18~32%, wetting agent 10~25%, emulsifying agent 3~12%, thickening agent 0.5~3%, surplus are deionized water.
Wherein, amino acid surfactant of the present invention is the one or more combination of fatty acyl group glutamate, fat acidyl glycine salt class, fatty acyl group alanine salt.One or more combination with sodium lauroyl glutamate salt, cocoyl sodium glutamate, cocoyl glycine potassium salt, cocoyl alanine sodium salt is advisable.
Wetting agent of the present invention is the one or more combination of polyhydric alcohol, amino acid humectant, nature moisturizing factor NMF.Preferably, be the one or more combination of propylene glycol, glycerol, trimethyl glycine lactone, L-pyrrolidone sodium carboxylate.
Emulsifying agent of the present invention is the one or more combination of refining Apis cerana Fabricius, glyceryl stearate, stearyl alcohol polyoxyethylene (21) ether, polyoxyethylene sorbitan fatty acid ester, Span.Preferably, be a kind of of refining Apis cerana Fabricius, glyceryl stearate or its combination, wherein the fusing point of refining Apis cerana Fabricius is 35~42 ℃.
Thickening agent of the present invention is the one or more combination of the two stearates of polyethylene glycol 6000, methyl glucoside polyoxyethylene (120) ether dioleate, acrylate/polyoxyethylene-20 octadecanol ether methyl-prop diluted acid ester copolymer, hydroxyethyl-cellulose, acrylate copolymer.
In addition, in formula system of the present invention, can also add an amount of essence, antiseptic as required.
Another object of the present invention is achieved by the following technical programs:
The preparation method of above-mentioned amino acid pattern faintly acid facial cleaning cream provided by the invention is: each component is added in the deionized water, and stirring makes it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 30~60min leaves standstill to remove blibbing slightly to transparent clarification shape; Be cooled to 43~50 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 30~45min, promptly get the paste finished product after leaving standstill 12~24h.
The present invention has following beneficial effect:
(1) facial cleaning cream of the present invention adopts the All Pure Nature amino acid type surfactant to make, and 100% does not contain soap matter, and its clean skin composition can gentlely effectively be removed various dirts, and forms protecting film at skin surface, thereby realizes safeguarding the purpose of skin health.
(2) goods itself are faintly acid, pH value is stabilized between 5.5~6.5, in full accord with the mean ph value of skin, the skin affinity is outstanding, chafe does not have tight sense, can recover skin protection function behind the clean skin rapidly, make skin profit, acid-base balance, but be fit to any skin matter and life-time service.
(3) need not in the product compounding system to add adjuvants such as pearlescent flake or Pearl Concentrate,, can obtain the pearly-lustre toothpaste-like effect of the beautiful exquisiteness of outward appearance by the distinctive apparent pearly-lustre characteristic of amino acid surfactant.
(4) preparation method of the present invention is simple, and physical process just, does not relate to chemical reaction, so processing and preparing produces and be reversible process, and the product of shaping still can reheat allotment.
The specific embodiment
Embodiment one:
Present embodiment amino acid pattern faintly acid facial cleaning cream, its raw material consists of by weight percentage:
Sodium lauroyl glutamate 30.0%
Trimethyl glycine lactone 18.0%
Glycerol 3.0%
L-pyrrolidone sodium carboxylate (50%) 2.0%
Refining Apis cerana Fabricius 4.0%
Glyceryl stearate 2.0%
The deionized water surplus
Can add an amount of essence, antiseptic in addition, consumption is 0.3~0.8% of an above-mentioned gross weight.
The preparation method of present embodiment amino acid pattern faintly acid facial cleaning cream is as follows:
Each component is added in the deionized water, and stirring makes it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 45min, at this moment, solution is the clear shape, according to circumstances, slightly leaves standstill 10~20min and eliminates the liquid level steam bubble; Be cooled to 47~49 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 30min, add an amount of essence, antiseptic as required, stir 5~10min after, promptly get the paste finished product after leaving standstill 12h.
Embodiment two:
Present embodiment amino acid pattern faintly acid facial cleaning cream, its raw material consists of by weight percentage:
Sodium lauroyl glutamate 25.0%
Cocoyl Kaglutam (30%) 5.0%
Trimethyl glycine lactone 16.0%
L-pyrrolidone sodium carboxylate (50%) 4.0%
Glycerol 3.0%
Refining Apis cerana Fabricius 9.0%
The two stearates 1.0% of polyethylene glycol 6000
The deionized water surplus
The preparation method of present embodiment amino acid pattern faintly acid facial cleaning cream is as follows:
Each component is added in the deionized water, and stirring makes it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 30min, at this moment, solution is the clear shape, according to circumstances, slightly leaves standstill 10~20min and eliminates the liquid level steam bubble; Be cooled to 45~47 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 45min, promptly get the paste finished product after leaving standstill 14h.
Embodiment three:
Present embodiment amino acid pattern faintly acid facial cleaning cream, its raw material consists of by weight percentage:
Sodium lauroyl glutamate 20.0%
Cocoyl alanine triethanolamine (30%) 10.0%
Trimethyl glycine lactone 12.0%
Glycerol 10.0%
Refining Apis cerana Fabricius 7.0%
Glyceryl stearate 2.0%
The deionized water surplus
The preparation method of present embodiment amino acid pattern faintly acid facial cleaning cream is as follows:
Each component is added in the deionized water, and stirring makes it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 60min, at this moment, solution is the clear shape, according to circumstances, slightly leaves standstill 10~20min and eliminates the liquid level steam bubble; Be cooled to 43~45 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 40min, promptly get the paste finished product after leaving standstill 14h.
Embodiment four:
Present embodiment amino acid pattern faintly acid facial cleaning cream, its raw material consists of by weight percentage:
Sodium lauroyl glutamate 18.0%
Cocoyl glycine potassium (30%) 10.0%
Trimethyl glycine sodium ester 10.0%
Glycerol 12.0%
Refining Apis cerana Fabricius 5.0%
The two stearates 2.0% of polyethylene glycol 6000
The deionized water surplus
The preparation method of present embodiment amino acid pattern faintly acid facial cleaning cream is as follows:
Each component is added in the deionized water, and stirring makes it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 50min, at this moment, solution is the clear shape, according to circumstances, slightly leaves standstill 10~20min and eliminates the liquid level steam bubble; Be cooled to 43~45 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 30min, promptly get the paste finished product after leaving standstill 24h.
A kind of amino acid pattern faintly acid of the present invention facial cleaning cream and preparation method thereof, its constitutive material and technological parameter are not limited to above-mentioned listed examples.

Claims (10)

1. amino acid pattern faintly acid facial cleaning cream, it is characterized in that its raw material consists of by weight percentage: amino acid surfactant 15~40%, wetting agent 5~30%, emulsifying agent 2~15%, thickening agent 0~3%, surplus are deionized water.
2. amino acid pattern faintly acid facial cleaning cream according to claim 1 is characterized in that its raw material consists of by weight percentage: amino acid surfactant 18~32%, wetting agent 10~25%, emulsifying agent 3~12%, thickening agent 0.5~3%, surplus are deionized water.
3. amino acid pattern faintly acid facial cleaning cream according to claim 1 and 2 is characterized in that: described amino acid surfactant is the one or more combination of fatty acyl group glutamate, fat acidyl glycine salt class, fatty acyl group alanine salt.
4. amino acid pattern faintly acid facial cleaning cream according to claim 3 is characterized in that: described amino acid surfactant is the one or more combination of sodium lauroyl glutamate salt, cocoyl sodium glutamate, cocoyl glycine potassium salt, cocoyl alanine sodium salt.
5. amino acid pattern faintly acid facial cleaning cream according to claim 1 and 2 is characterized in that: described wetting agent is the one or more combination of polyhydric alcohol, amino acid humectant, nature moisturizing factor NMF.
6. amino acid pattern faintly acid facial cleaning cream according to claim 5 is characterized in that: described wetting agent is the one or more combination of propylene glycol, glycerol, trimethyl glycine lactone, L-pyrrolidone sodium carboxylate.
7. amino acid pattern faintly acid facial cleaning cream according to claim 1 and 2 is characterized in that: described emulsifying agent is the one or more combination of refining Apis cerana Fabricius, glyceryl stearate, stearyl alcohol polyoxyethylene (21) ether, polyoxyethylene sorbitan fatty acid ester, Span.
8. amino acid pattern faintly acid facial cleaning cream according to claim 7 is characterized in that: described emulsifying agent is a kind of of refining Apis cerana Fabricius, glyceryl stearate or its combination, and wherein the fusing point of refining Apis cerana Fabricius is 35~42 ℃.
9. amino acid pattern faintly acid facial cleaning cream according to claim 1 and 2 is characterized in that: described thickening agent is the one or more combination of the two stearates of polyethylene glycol 6000, methyl glucoside polyoxyethylene (120) ether dioleate, acrylate/polyoxyethylene-20 octadecanol ether methyl-prop diluted acid ester copolymer, hydroxyethyl-cellulose, acrylate copolymer.
10. the described amino acid pattern faintly acid of one of the claim 1-9 preparation method of buying face cream is characterized in that: each component is added in deionized water, and stir and make it to disperse; Be heated to 80~85 ℃ then, stirring and dissolving 30~60min leaves standstill to remove blibbing slightly to transparent clarification shape; Be cooled to 43~50 ℃, treat that dissolved transparent fluid viscosity increases when beginning to be emulsion form and slowly having pearly-lustre to separate out, continue to stir 30~45min, promptly get the paste finished product after leaving standstill 12~24h.
CN 201110001976 2011-01-06 2011-01-06 Amino acid type weak acid facial cleanser and preparation method thereof Active CN102048653B (en)

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102978048A (en) * 2012-11-16 2013-03-20 广州伊凡生物科技有限公司 Weakly acidic transparent soap and preparation method thereof
CN102988243A (en) * 2012-12-21 2013-03-27 宁波御坊堂生物科技有限公司 Face cleaning crystal hard gel and preparation method thereof
CN104027254A (en) * 2013-03-08 2014-09-10 广东雅威生物科技有限公司 Cosmetic composition and its use and preparation technology
CN104257527A (en) * 2014-10-22 2015-01-07 广东幸美化妆品股份有限公司 Moisturizing facial cleanser and preparation method thereof
CN104398442A (en) * 2014-12-08 2015-03-11 罗昕 Traditional Chinese medicine-containing facial cleanser
CN104398462A (en) * 2014-12-08 2015-03-11 罗昕 Oil-control facial cleanser
CN104434644A (en) * 2014-11-14 2015-03-25 唯美度科技(北京)有限公司 Facial cleanser containing cucumber extraction
CN104490728A (en) * 2014-12-08 2015-04-08 罗昕 Acne-removing facial cleanser
CN104531371A (en) * 2014-12-12 2015-04-22 无限极(中国)有限公司 Weakly-acidic high transparent soap and preparation method thereof
CN104606071A (en) * 2015-02-06 2015-05-13 深圳唯美度生物科技有限公司 Facial cleanser for effectively preventing haze hazards
CN105456066A (en) * 2015-12-11 2016-04-06 彭再辉 Novel face-cleansing composition and preparation method of finished product of face-cleansing composition
CN105997658A (en) * 2016-06-18 2016-10-12 广州丹奇日用化工厂有限公司 Facial cleansing cream containing herba cichorii flavone substance and preparation method of facial cleanser
CN106344464A (en) * 2016-11-04 2017-01-25 王少琼 Amino acid facial cleanser as well as preparation method and application thereof
CN106361644A (en) * 2016-11-04 2017-02-01 王少琼 Multifunctional whitening and moisturizing facial cleanser as well as preparation method and application thereof
CN106491381A (en) * 2016-12-06 2017-03-15 诺斯贝尔化妆品股份有限公司 A kind of gentle pure amino acid facial cleaning cream of crystal type
CN106726873A (en) * 2016-11-21 2017-05-31 西安博和医疗科技有限公司 Amino acid clean water and preparation method thereof
CN107260562A (en) * 2017-06-20 2017-10-20 彭再辉 Amino acid mildy wash and preparation method thereof
CN107468608A (en) * 2017-08-10 2017-12-15 浙江大学 A kind of plant source amino acid mildy wash and preparation method thereof
CN107898711A (en) * 2017-12-28 2018-04-13 齐鲁工业大学 A kind of amino acid pattern moisturizing face cleaning foam
CN108125859A (en) * 2018-01-15 2018-06-08 陕西慧康生物科技有限责任公司 A kind of multi-functional amino acid cleansing cream and preparation method thereof
CN108272665A (en) * 2018-04-18 2018-07-13 杭州百芮生物科技有限公司 A kind of weak acid acidic amino acid skin-clean cream and preparation method thereof
CN105832572B (en) * 2016-04-07 2018-08-17 广州宏度精细化工有限公司 Amino acid facial cleanser and preparation method thereof
CN109394560A (en) * 2018-12-14 2019-03-01 广州润虹医药科技股份有限公司 A kind of amino acid cleansing cream and preparation method thereof
CN110638715A (en) * 2019-11-14 2020-01-03 广州一一生物技术有限公司 Male facial cleanser and preparation method thereof
CN112168718A (en) * 2020-10-12 2021-01-05 天津强微特生物科技有限公司 Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof
CN112675096A (en) * 2021-01-22 2021-04-20 上海加新生物科技有限公司 Bacteriostatic and bactericidal plant composite composition and preparation method thereof
CN114748379A (en) * 2022-05-05 2022-07-15 有货(北京)信息技术有限公司 NMN-containing pure crystalline amino acid facial cleanser and preparation method thereof

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CN102978048A (en) * 2012-11-16 2013-03-20 广州伊凡生物科技有限公司 Weakly acidic transparent soap and preparation method thereof
CN102978048B (en) * 2012-11-16 2014-11-05 广州伊凡生物科技有限公司 Weakly acidic transparent soap and preparation method thereof
CN102988243A (en) * 2012-12-21 2013-03-27 宁波御坊堂生物科技有限公司 Face cleaning crystal hard gel and preparation method thereof
CN102988243B (en) * 2012-12-21 2014-12-03 宁波御坊堂生物科技有限公司 Face cleaning crystal hard gel and preparation method thereof
CN104027254A (en) * 2013-03-08 2014-09-10 广东雅威生物科技有限公司 Cosmetic composition and its use and preparation technology
CN104257527A (en) * 2014-10-22 2015-01-07 广东幸美化妆品股份有限公司 Moisturizing facial cleanser and preparation method thereof
CN104434644A (en) * 2014-11-14 2015-03-25 唯美度科技(北京)有限公司 Facial cleanser containing cucumber extraction
CN104398462A (en) * 2014-12-08 2015-03-11 罗昕 Oil-control facial cleanser
CN104490728A (en) * 2014-12-08 2015-04-08 罗昕 Acne-removing facial cleanser
CN104398442A (en) * 2014-12-08 2015-03-11 罗昕 Traditional Chinese medicine-containing facial cleanser
CN104531371A (en) * 2014-12-12 2015-04-22 无限极(中国)有限公司 Weakly-acidic high transparent soap and preparation method thereof
CN104606071A (en) * 2015-02-06 2015-05-13 深圳唯美度生物科技有限公司 Facial cleanser for effectively preventing haze hazards
CN105456066A (en) * 2015-12-11 2016-04-06 彭再辉 Novel face-cleansing composition and preparation method of finished product of face-cleansing composition
CN105832572B (en) * 2016-04-07 2018-08-17 广州宏度精细化工有限公司 Amino acid facial cleanser and preparation method thereof
CN105997658A (en) * 2016-06-18 2016-10-12 广州丹奇日用化工厂有限公司 Facial cleansing cream containing herba cichorii flavone substance and preparation method of facial cleanser
CN106344464A (en) * 2016-11-04 2017-01-25 王少琼 Amino acid facial cleanser as well as preparation method and application thereof
CN106361644A (en) * 2016-11-04 2017-02-01 王少琼 Multifunctional whitening and moisturizing facial cleanser as well as preparation method and application thereof
CN106726873A (en) * 2016-11-21 2017-05-31 西安博和医疗科技有限公司 Amino acid clean water and preparation method thereof
CN106491381A (en) * 2016-12-06 2017-03-15 诺斯贝尔化妆品股份有限公司 A kind of gentle pure amino acid facial cleaning cream of crystal type
CN107260562A (en) * 2017-06-20 2017-10-20 彭再辉 Amino acid mildy wash and preparation method thereof
CN107468608A (en) * 2017-08-10 2017-12-15 浙江大学 A kind of plant source amino acid mildy wash and preparation method thereof
CN107898711A (en) * 2017-12-28 2018-04-13 齐鲁工业大学 A kind of amino acid pattern moisturizing face cleaning foam
CN108125859A (en) * 2018-01-15 2018-06-08 陕西慧康生物科技有限责任公司 A kind of multi-functional amino acid cleansing cream and preparation method thereof
CN108272665A (en) * 2018-04-18 2018-07-13 杭州百芮生物科技有限公司 A kind of weak acid acidic amino acid skin-clean cream and preparation method thereof
CN109394560B (en) * 2018-12-14 2022-08-16 广州倍健医疗用品有限公司 Amino acid facial cleanser and preparation method thereof
CN109394560A (en) * 2018-12-14 2019-03-01 广州润虹医药科技股份有限公司 A kind of amino acid cleansing cream and preparation method thereof
CN110638715A (en) * 2019-11-14 2020-01-03 广州一一生物技术有限公司 Male facial cleanser and preparation method thereof
CN112168718B (en) * 2020-10-12 2022-08-02 天津强微特生物科技有限公司 Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof
CN112168718A (en) * 2020-10-12 2021-01-05 天津强微特生物科技有限公司 Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof
CN112675096A (en) * 2021-01-22 2021-04-20 上海加新生物科技有限公司 Bacteriostatic and bactericidal plant composite composition and preparation method thereof
CN112675096B (en) * 2021-01-22 2022-11-08 上海加新生物科技有限公司 Bacteriostatic and bactericidal plant composite composition and preparation method thereof
CN114748379A (en) * 2022-05-05 2022-07-15 有货(北京)信息技术有限公司 NMN-containing pure crystalline amino acid facial cleanser and preparation method thereof
CN114748379B (en) * 2022-05-05 2023-10-24 有货(北京)信息技术有限公司 Pure crystal type amino acid facial cleanser containing NMN and preparation method thereof

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