CN112168718B - Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof - Google Patents
Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof Download PDFInfo
- Publication number
- CN112168718B CN112168718B CN202011084436.5A CN202011084436A CN112168718B CN 112168718 B CN112168718 B CN 112168718B CN 202011084436 A CN202011084436 A CN 202011084436A CN 112168718 B CN112168718 B CN 112168718B
- Authority
- CN
- China
- Prior art keywords
- skin
- percent
- ecology
- face
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses a face-cleaning gel composition capable of adjusting the microecological balance of skin and a preparation method thereof. The composition comprises a surfactant, a thickener, a preservative, a polyol, a pH adjuster, and water. The composition overcomes the side effect of the traditional cleansing product on the microecology of skin by optimizing the components and optimizing the preparation proportion, has multiple effects of cleanness, no stimulation and friendly skin barrier function, provides a new idea for solving the skin problem, and is favorable for maintaining the microbial balance on the surface of the skin through the experimental verification of the skin of a human body.
Description
Technical Field
The invention relates to a skin cleanser, belongs to the technical field of daily cosmetics, and particularly relates to a face-cleaning gel for maintaining skin micro-ecology and a preparation method thereof.
Background
The skin is the largest organ of the human body and has a layer with a density of up to 10 on its surface 6 /cm 2 The skin microorganisms of (1), which form a huge biological barrier at the skin surface. The skin microbiome is a dynamically variable, complex ecosystem and is therefore also referred to as skin micro-ecology. The skin micro-ecology interacts with the skin keratinocytes and the host immune system, affecting the skin's own immune regulation and barrier protection functions. An increasing number of studies have shown that a dysbiosis of the skin is associated with a number of skin disorders, such as acne, folliculitis, atopic dermatitis, etc.
The components of the cleansing product as a daily-used skin care product are complex, and the daily use of the cosmetic product is proved by documents to possibly cause the change of normal flora and destroy the protection function of the normal flora, especially sensitive skin. Therefore, strict control of cosmetic ingredients plays an important role in maintaining the skin microecological balance. At present, the existing products for maintaining the skin micro-ecology are added with active compositions for regulating the balance of the skin micro-ecology. For example, chinese patent application 201310469004.X discloses a composition for promoting skin microecological balance and a preparation method thereof, wherein the composition comprises skin prebiotics α -glucan oligosaccharide, fructooligosaccharide, β -glucan, a plant extract, a yeast extract and a filtrate of a fermentation product of natural antibacterial agent leuconostoc/radish root as main ingredients. Chinese patent application 201910015398.9 discloses a composition capable of regulating skin microecological balance, application thereof, and a skin lotion containing the same and a preparation method of the skin lotion. However, cosmetic ingredients are complex and the active is only part of the product.
The cleansing product is used as the first step of daily cleaning and nursing, mainly contains components such as a surfactant, a thickening agent, a preservative and the like, and has the function of removing facial dirt and redundant grease. Unsuitable cleansing products can disrupt the skin barrier structure and affect the skin's micro-ecological balance, such as cationic surfactants which have a killing effect on a broad range of gram positive and partially gram negative bacteria. The mild raw materials and the microecological raw materials which are commonly known by the people are not a concept, a plurality of cleaning components with low alleviative stimulation and mild are declared, and experiments prove that the cleaning components can also have great inhibition effect on skin microorganisms, such as decyl glucoside serving as a surfactant; while typical highly irritating SLES (sodium polyoxyethylene lauryl sulfate) and the like can directly irritate mucous membranes and destroy barriers, the inhibition effect on skin microorganisms is not necessarily strong. Meanwhile, research reports that only water can wash away 65% of dirt and grease on the skin surface, so that a small amount of surfactant can actually achieve the effect of cleaning the skin. The preservative is an essential component in most cosmetics, and is mainly used for inhibiting the growth of microorganisms and ensuring the stable quality and safety of the cosmetics. The antiseptic has no selectivity in inhibiting microbe, so that it has great inhibition on normal microbe in skin, and some antiseptic with less inhibition on microbe growth may be screened in the action concentration. Research shows that the pH of the face cleaning product also has great influence on the re-planting and regeneration of microorganisms on the surface of the skin, the normal skin surface presents weak acidity, the pH of the skin surface is increased after the face cleaning product is cleaned by using an alkaline product, the skin is recovered to the physiological acidic pH for several hours, the maintenance of the weak acidic physiological pH of the skin is beneficial to the epidermal physiological barrier and the skin microorganism barrier, and the selection of the weak acidic face cleaning product is more beneficial to the maintenance of the skin microecology.
The main current viewpoint of maintaining skin microecology with cosmetics focuses on promoting microecological balance by adding active substances, but in fact, the matrix components of cosmetics such as thickening agents, emulsifiers, preservatives, surfactants, oils and the like are high in the cosmetics, and the active substances only account for 10% of the formula, so the selection of the matrix components of the face cleaning product has a great influence on maintaining skin microecology.
Disclosure of Invention
In order to solve the problem that the existing skin cleaning product cannot provide the function of adjusting the microecological balance of the skin, the invention aims to provide a formula of the face cleaning gel which not only has cleaning capability, but also can maintain the microecological balance of the skin, so as to solve the problem that the existing face cleaning product has great influence on the microecological balance of the skin.
The invention also aims to provide a preparation method of the cleansing gel for maintaining the micro-ecology of the skin, which has simple processing technology and no need of complex processing steps in the preparation process and is suitable for large-scale production and preparation.
In order to achieve the purpose, the invention mainly adopts the following technical scheme:
a face-cleaning jelly for maintaining skin micro-ecology comprises the following components in percentage by weight: 1-50% of surfactant, 0.1-10% of thickening agent, 0.1-5% of preservative, 0-10% of polyalcohol, 0-1% of pH regulator and the balance of deionized water;
preferably, the cleansing gel for maintaining skin micro-ecology comprises the following components in parts by weight: 20-30% of surfactant, 0.5-8% of thickening agent, 0.5-2% of preservative, 2-4% of polyalcohol, 0.2-0.4% of pH regulator and the balance of deionized water;
the invention is also characterized in that the surfactant comprises one or more of sodium cocoyl methyl taurate, sodium methyl cocoyl taurate and lauryl glucoside; preferably, the surfactant is sodium cocoyl methyl taurate.
The thickener is one or more of acryloyl dimethyl ammonium taurate/VP copolymer, xanthan gum, hydroxyethyl cellulose, acrylic acid (ester) copolymer and polyacrylate cross-linked polymer-6; preferably, the thickener is xanthan gum, hydroxyethyl cellulose, acrylic acid (ester) copolymer.
The antiseptic is one or more of methyl paraben, phenoxyethanol and ethylhexyl glycerin mixture, octyl glycol, p-hydroxyacetophenone, 1, 2-hexanediol, and potassium sorbate; preferably, the preservative is p-hydroxyacetophenone, 1, 2-hexanediol.
The polyalcohol is one or more of glycerol, butanediol, propylene glycol and pentanediol; preferably, the polyol is butanediol.
The pH regulator is one or more of sodium hydroxide, potassium hydroxide, triethanolamine and arginine; preferably, the pH adjusting agent is sodium hydroxide.
The invention also provides a preparation method of the face-cleaning jelly for maintaining skin micro-ecology, which comprises the following steps:
s1, dispersing the thickening agent in the polyhydric alcohol, adding water, stirring and heating to 80-85 ℃, and keeping the temperature for 20 minutes;
s2, cooling to 40-50 ℃, adding the surfactant and the preservative, and stirring uniformly;
s3, adjusting the pH value to a required range by using a pH regulator, cooling to 30-40 ℃, and discharging.
Compared with the prior art, the invention has the following beneficial effects:
(1) the surfactant, the thickening agent and the preservative are screened out through an antibacterial test, and are friendly to skin microorganisms, and the experiment takes resident bacteria staphylococcus epidermidis and staphylococcus capitis in the skin as experimental bacteria to carry out the antibacterial test, so that the component with the weakest inhibition effect on the growth of the experimental bacteria is screened out; meanwhile, the pH value of the product is adjusted to be weakly acidic, so that the skin physiology and skin microbial flora steady state can be maintained.
(2) The jelly has moderate cleaning power, has moisturizing effect on skin and hair, and is not tight after washing.
(3) The composition solves the problem of skin microecological imbalance caused by skin cleaning from the perspective of a matrix formula, and provides a new idea for solving the skin problem.
(4) The preparation method of the composition is simple and feasible, and is suitable for large-scale production by reasonably controlling the production process steps and the temperature.
Detailed Description
To better illustrate the objects, technical solutions and advantages of the present invention, the following embodiments are specifically described below. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention.
Examples 1-3 and comparative examples 1-3 are in the following proportions:
table one example and comparative example ingredient ratio
The method of making the cleansing gel of example 1, according to the following steps:
1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water and p-hydroxyacetophenone, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
2) cooling to 45 deg.C, adding acrylic acid (ester) copolymer, sodium cocoyl methyl taurate and 1, 2-hexanediol, and stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The method of making the cleansing gel of example 2, according to the following steps:
1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water and p-hydroxyacetophenone, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
2) cooling to 45 deg.C, adding acrylic acid (ester) copolymer, sodium methyl cocoyl taurate, and 1, 2-hexanediol, and stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The method of making the cleansing gel of example 3, according to the following steps:
1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water and p-hydroxyacetophenone, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
2) cooling to 45 deg.C, adding acrylic acid (ester) copolymer, sodium cocoyl methyl taurate and 1, 2-hexanediol, and stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The method of preparing the cleansing gel of comparative example 1, according to the following steps:
1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water and p-hydroxyacetophenone, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
2) cooling to 45 deg.C, adding acrylic acid (ester) copolymer, coco glucoside, and 1, 2-hexanediol, and stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The method of preparing the cleansing gel of comparative example 2, according to the following steps:
1) dispersing carbomer in water, adding butanediol and p-hydroxyacetophenone, stirring, heating to 80 deg.C, and keeping the temperature for 20 min;
2) cooling to 45 ℃, adding sodium cocoyl methyl taurate and 1, 2-hexanediol, and uniformly stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The method for preparing the cleansing gel of comparative example 3 comprises the following steps:
1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
2) cooling to 45 deg.C, adding acrylic acid (ester) copolymer, coco glucoside, and potassium sorbate, and stirring;
3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
The following efficacy evaluations were performed on the cleansing gel prepared by the present invention:
(I) bacteriostatic test
The friendliness of the facial cleansing gel to skin microorganisms is judged by carrying out bacteriostasis experiments on skin resident bacteria staphylococcus epidermidis and staphylococcus capitis.
The experimental method is as follows:
preparation of bacterial suspensions of staphylococcus epidermidis and staphylococcus capitis: selecting a small amount of strains by using a sterile gun head, carrying out streak culture on an LB culture medium, and culturing for 24h at 37 ℃; picking single colony with aseptic gun head into liquid culture medium, culturing at 37 deg.C for 24 hr, and determining the concentration of bacterial suspension to be 10 6 CFU/mL。
Taking 0.1 ml of the gel samples of the examples and the comparative examples, adding the gel samples into 1 ml of the bacterial suspension diluted by 10 times, replacing the gel with physiological saline in a blank control group, carrying out shake culture at 37 ℃ for 24h, and measuring the bacterial quantity by using a dilution method.
Bacteriostatic experiment results of samples in Table II
Analysis table two shows that after the co-culture of the bacteria liquid and the examples, the bacteria number is equivalent to that of the blank control group, which indicates that the facial cleansing gel prepared by the examples has no influence on the growth of the two skin resident bacteria and is beneficial to maintaining the original microecological balance of the skin; and the comparative examples 1 to 3 have obvious inhibition effect on the growth of the two bacteria. The components in the formula of the cosmetic are complex, and compared with the examples, the comparative examples 1 to 3 only change one of the surfactant, the thickening agent or the preservative, but have great influence on the growth of two bacteria. The surfactant can destroy phospholipid bilayer of bacterial cell membrane to cause thallus rupture and inhibit microbial growth due to its amphipathic nature. The thickener is mostly a chemically synthesized macromolecular structure, and chemical residues and molecular structures of the thickener can also have certain influence on the growth of microorganisms. The preservative has a more obvious bacteriostatic action on microorganisms due to the bacteriostatic property of the preservative. The facial cleansing gel designed by the invention has no influence on the growth of test bacteria through strictly screening a formula frame system, and a bacteriostatic test shows that the facial cleansing gel formula frame system designed by the invention has great significance for maintaining skin micro-ecology.
(II) human skin test
The human skin test was performed on examples 1,2 and 1, and 60 volunteers were selected for the test, randomly divided into 3 groups of 20 persons, and the cleansing gels of examples 1,2 and 1 were used respectively every morning and evening for 30 days to evaluate the cleansing power, irritation and skin comfort.
Evaluation results of skin test of human body
As can be seen from the results of the skin tests on the human body in Table III, 90% of the volunteers who used the face-cleansing gel of comparative example 1 had strong reactive cleansing power and had a significant tightening feeling after washing. Two volunteers fed back the use of the face-cleaning gel of comparative example 1, the rear part of the face-cleaning gel appeared to be reddish and itchy, and 6 volunteers fed back the face to be dry. The cleansing gel prepared in the embodiment 1 and the embodiment 2 has moderate cleansing capability, meets the cleansing requirement of the cleansing product, gives feedback to volunteers uniformly without irritation, ensures that the skin is soft and not tight after cleansing, is friendly to the skin barrier function, and is beneficial to maintaining the balance of microorganisms on the surface of the skin.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are still in the protection scope of the invention.
Claims (2)
1. A face-cleaning jelly for maintaining skin micro-ecology is characterized in that: comprises the following components in percentage by weight: 20 percent of cocoyl methyl taurine sodium taurate (25 percent solution), 0.2 percent of xanthan gum, 0.3 percent of hydroxyethyl cellulose, 7 percent of acrylic acid (ester) copolymer (30 percent solution), 0.5 percent of p-hydroxyacetophenone, 0.5 percent of 1, 2-hexanediol, 2 percent of butanediol, a plurality of sodium hydroxide, and the balance of water to 100 percent.
2. A facial gel for maintaining skin micro-ecology according to claim 1, wherein: the jelly is prepared by the following process steps:
(1) dispersing xanthan gum and hydroxyethyl cellulose in butanediol, adding water and p-hydroxyacetophenone, stirring, heating to 80 ℃, and keeping the temperature for 20 minutes;
(2) cooling to 45 ℃, adding coconut oil acyl methyl taurine sodium taurate, acrylic acid (ester) copolymer and 1, 2-hexanediol, and uniformly stirring;
(3) adjusting pH to 6.0 with sodium hydroxide, cooling to 35 deg.C, and discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011084436.5A CN112168718B (en) | 2020-10-12 | 2020-10-12 | Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011084436.5A CN112168718B (en) | 2020-10-12 | 2020-10-12 | Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112168718A CN112168718A (en) | 2021-01-05 |
| CN112168718B true CN112168718B (en) | 2022-08-02 |
Family
ID=73949160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011084436.5A Active CN112168718B (en) | 2020-10-12 | 2020-10-12 | Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112168718B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101248A (en) * | 2021-04-21 | 2021-07-13 | 广州诺然生物科技有限公司 | Composition for promoting skin microecological balance and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048653A (en) * | 2011-01-06 | 2011-05-11 | 广州壹凡化工有限公司 | Amino acid type weak acid facial cleanser and preparation method thereof |
| KR20140111198A (en) * | 2013-03-08 | 2014-09-18 | 단국대학교 천안캠퍼스 산학협력단 | Pharmaceutical composition for preventing or treating infectious diseases of skin comprising 5-Aminolevulinic acid |
| CN106667782A (en) * | 2017-03-01 | 2017-05-17 | 广州市花安堂生物科技有限公司 | Cleansing gel and preparation method thereof |
| CN108403609A (en) * | 2018-06-01 | 2018-08-17 | 广州澳希亚实业有限公司 | One kind is compacted moisturizing face cleaning gel |
| CN110074991A (en) * | 2019-05-28 | 2019-08-02 | 南靖珠曼生物科技有限公司 | A kind of amino acid facial cleanser and processing technology |
| CN110812261A (en) * | 2018-08-14 | 2020-02-21 | 完美（中国）有限公司 | Crystalline amino acid facial cleanser and preparation method thereof |
-
2020
- 2020-10-12 CN CN202011084436.5A patent/CN112168718B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048653A (en) * | 2011-01-06 | 2011-05-11 | 广州壹凡化工有限公司 | Amino acid type weak acid facial cleanser and preparation method thereof |
| KR20140111198A (en) * | 2013-03-08 | 2014-09-18 | 단국대학교 천안캠퍼스 산학협력단 | Pharmaceutical composition for preventing or treating infectious diseases of skin comprising 5-Aminolevulinic acid |
| CN106667782A (en) * | 2017-03-01 | 2017-05-17 | 广州市花安堂生物科技有限公司 | Cleansing gel and preparation method thereof |
| CN108403609A (en) * | 2018-06-01 | 2018-08-17 | 广州澳希亚实业有限公司 | One kind is compacted moisturizing face cleaning gel |
| CN110812261A (en) * | 2018-08-14 | 2020-02-21 | 完美（中国）有限公司 | Crystalline amino acid facial cleanser and preparation method thereof |
| CN110074991A (en) * | 2019-05-28 | 2019-08-02 | 南靖珠曼生物科技有限公司 | A kind of amino acid facial cleanser and processing technology |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112168718A (en) | 2021-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102057022B1 (en) | Cosmetic composition and manufacturing method for the same | |
| WO2021003962A1 (en) | Skincare composition for repairing skin, and preparation method therefor | |
| DE102005026069A1 (en) | Topical cosmetic formulations for regulating and improving the moisture content of the skin | |
| CN110859766B (en) | Scalp multi-azimuth care composition and application thereof | |
| CN111920732B (en) | Mite-killing conditioner, shampoo and preparation method thereof | |
| CN101926741A (en) | Skin refinishing essence and skin care product with same | |
| CN111759792A (en) | Preservative-free moisturizing mask liquid and preparation method thereof | |
| CN115569105B (en) | Composition containing rice hull extract for removing dandruff, controlling oil, inhibiting bacteria and removing mites | |
| CN111249217A (en) | Cleansing liquid for adjusting skin micro-ecological balance and preparation method thereof | |
| CN112168718B (en) | Face-cleaning gel for maintaining skin micro-ecology and preparation method thereof | |
| CN109875951B (en) | Hair cleaning care solution | |
| CN105326696A (en) | Natural plant antioxidant essence milk and preparation method thereof | |
| CN114557902A (en) | Oil-based gel capable of suspending particles, all-oil system bath gel and preparation method thereof | |
| CN113018246B (en) | Probiotic shampoo capable of relieving scalp inflammation and preparation method thereof | |
| CN116509774B (en) | Anti-dandruff shampoo preparation containing sweet wormwood herb extract and preparation method thereof | |
| TW202143944A (en) | A cosmetic composition for skin improvement comprising polysaccharides, yeast extracts and fermentation of strain having probiotics properties | |
| CN111904909A (en) | Dandruff-removing scalp essence containing rose fermentation liquor and preparation method thereof | |
| CN111297780A (en) | Long charcoal cleansing water-permeable moistening mask | |
| CN112006954B (en) | Shampoo and preparation method thereof | |
| CN111870590B (en) | Liquid acne-removing patch and preparation method thereof | |
| KR101876744B1 (en) | A step 3 method for improving skin condition using cosmetic composition comprising a ginseng extract | |
| CN111714404B (en) | Acne-removing composition and preparation method and application thereof | |
| CN108852977B (en) | Crystal moistening essence | |
| CN114522120A (en) | Grease composition for balancing skin microecology and skin moistening emulsion thereof | |
| US20240058252A1 (en) | Cosmetic method and composition based on short-chain fructooligosaccharides and a native starch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |