CN102036679A - 用松弛素治疗与急性心力衰竭相关的呼吸困难 - Google Patents
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
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- Peptides Or Proteins (AREA)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310127326.6A CN103212063B (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| CN201610565105.0A CN106177914A (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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| US19054508P | 2008-08-28 | 2008-08-28 | |
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| US20124008P | 2008-12-08 | 2008-12-08 | |
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| US16433309P | 2009-03-27 | 2009-03-27 | |
| US61/164,333 | 2009-03-27 | ||
| PCT/US2009/044249 WO2009140659A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating dyspnea associated with acute heart failure |
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| CN201310127326.6A Division CN103212063B (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| CN201610565105.0A Division CN106177914A (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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| CN201610565105.0A Pending CN106177914A (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| CN201310127326.6A Expired - Fee Related CN103212063B (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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| CN201610565105.0A Pending CN106177914A (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| CN201310127326.6A Expired - Fee Related CN103212063B (zh) | 2008-05-16 | 2009-05-15 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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| BR (1) | BRPI0913011A2 (ko) |
| CA (1) | CA2724540C (ko) |
| CR (1) | CR11749A (ko) |
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| MY (2) | MY159803A (ko) |
| NZ (3) | NZ701038A (ko) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103930440A (zh) * | 2011-07-01 | 2014-07-16 | 拜耳知识产权有限责任公司 | 松弛素融合多肽及其用途 |
| CN104220098A (zh) * | 2012-02-14 | 2014-12-17 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2462221B (en) * | 2008-05-16 | 2010-09-01 | Corthera Inc | Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure |
| MX2010012502A (es) * | 2008-05-16 | 2011-04-11 | Corthera Inc | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
| RU2564900C2 (ru) * | 2010-03-10 | 2015-10-10 | Дзе Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Модулирование аквапоринов релаксином |
| CA2802273A1 (en) | 2010-08-06 | 2012-02-09 | Pronota N.V. | Perlecan as a biomarker for renal dysfunction |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| MY162837A (en) | 2010-08-17 | 2017-07-31 | Ambrx Inc | Modified relaxin polypeptides and their uses |
| AU2013202269A1 (en) * | 2011-10-26 | 2013-05-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| EP2844345B1 (en) | 2012-05-04 | 2022-08-03 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Modulators of the relaxin receptor 1 |
| BR112015009291B1 (pt) | 2012-10-26 | 2021-03-16 | Chiesi Farmaceutici S.P.A | uso de clevidipina para controle da pressão arterial e redução da dispneia na insuficiência cardíaca |
| US9884039B2 (en) | 2013-04-05 | 2018-02-06 | Scpharmaceuticals Inc. | Pharmaceutical formulations for subcutaneous administration of furosemide |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| SG11201605273XA (en) * | 2014-02-03 | 2016-08-30 | Novartis Ag | Filters for infusion sets |
| EP2946788A1 (en) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| JP6820748B2 (ja) * | 2014-06-13 | 2021-01-27 | ノバルティス アーゲー | Ｇｄｆ−１５を減少させるためのセレラキシンの使用 |
| EP4011919A3 (en) | 2015-12-09 | 2022-10-12 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| WO2017139164A1 (en) | 2016-02-12 | 2017-08-17 | Cardiac Pacemakers, Inc. | Systems and methods for patient monitoring |
| ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| CN113271923A (zh) | 2019-01-04 | 2021-08-17 | Sq创新股份公司 | 呋塞米的药物组合物及其用途 |
| WO2020160210A1 (en) | 2019-01-31 | 2020-08-06 | Scpharmaceuticals Inc. | Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same |
| WO2024047130A1 (en) | 2022-08-31 | 2024-03-07 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Immunosuppressive medicament and method of treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| AU691189B2 (en) | 1993-06-21 | 1998-05-14 | Genentech Inc. | Process for producing relaxin |
| EP0675732B1 (en) | 1993-07-27 | 2006-06-28 | Mario Bigazzi | Use of relaxin in the manufacture of therapeutic agents |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| JP4568383B2 (ja) | 1995-08-15 | 2010-10-27 | コルセラ，インコーポレイティッド | 血管形成の促進方法 |
| ATE362770T1 (de) | 2000-02-09 | 2007-06-15 | Bas Medical Inc | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| US20070202080A1 (en) | 2004-03-30 | 2007-08-30 | Industry-University Cooperation Foundation Yonsei | Gene Delivery System Containing Relaxin Gene And Pharmaceutical Composition Using Relaxin |
| US20060264367A1 (en) | 2005-05-21 | 2006-11-23 | Howard Florey Institute | Prevention of fibrosis following cardiac injury |
| US20080077025A1 (en) | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
| EP2167534B1 (en) | 2007-07-12 | 2012-07-04 | Compugen Ltd. | Bioactive peptides and method of using same |
| MX2010012502A (es) | 2008-05-16 | 2011-04-11 | Corthera Inc | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
| GB2462221B (en) * | 2008-05-16 | 2010-09-01 | Corthera Inc | Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103930440A (zh) * | 2011-07-01 | 2014-07-16 | 拜耳知识产权有限责任公司 | 松弛素融合多肽及其用途 |
| CN104220098A (zh) * | 2012-02-14 | 2014-12-17 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
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