CN101978248A - 具有整合微流化生物标记物光学检测阵列装置的发现工具和使用方法 - Google Patents

具有整合微流化生物标记物光学检测阵列装置的发现工具和使用方法 Download PDF

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CN101978248A
CN101978248A CN2008801245973A CN200880124597A CN101978248A CN 101978248 A CN101978248 A CN 101978248A CN 2008801245973 A CN2008801245973 A CN 2008801245973A CN 200880124597 A CN200880124597 A CN 200880124597A CN 101978248 A CN101978248 A CN 101978248A
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sample
zymolyte
substrate
equipment
kinase
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P·沈
L·蒋
K·蒋
陈仲中
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Dynamic Throughput Inc
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Dynamic Throughput Inc
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Priority claimed from US11/970,451 external-priority patent/US7952705B2/en
Priority claimed from US12/191,812 external-priority patent/US20090097022A1/en
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore

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  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2008801245973A 2008-01-07 2008-10-31 具有整合微流化生物标记物光学检测阵列装置的发现工具和使用方法 Pending CN101978248A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/970,451 2008-01-07
US11/970,451 US7952705B2 (en) 2007-08-24 2008-01-07 Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US12/191,812 US20090097022A1 (en) 2007-08-24 2008-08-14 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use
US12/191,812 2008-08-14
PCT/US2008/012369 WO2009088408A1 (en) 2008-01-07 2008-10-31 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use

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CN101978248A true CN101978248A (zh) 2011-02-16

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EP (1) EP2229578A4 (https=)
JP (1) JP2011511933A (https=)
CN (1) CN101978248A (https=)
AU (1) AU2008347152A1 (https=)
CA (1) CA2710828A1 (https=)
WO (1) WO2009088408A1 (https=)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103718038A (zh) * 2011-05-29 2014-04-09 韩国化学研究院 高速的基于拉曼分析的多药物高速筛选装置
WO2015010545A1 (zh) * 2013-07-25 2015-01-29 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
CN104880391A (zh) * 2015-06-23 2015-09-02 好来化工(中山)有限公司 用于检测唾液中颗粒物质的装置
CN105100560A (zh) * 2014-05-21 2015-11-25 东和株式会社 电子零件封装体侧面摄影装置
CN105143858A (zh) * 2013-03-14 2015-12-09 惠普发展公司，有限责任合伙企业 用来检测物质的器件和产生这样的器件的方法
CN106574231A (zh) * 2014-05-07 2017-04-19 原子能和替代能源委员会 缺少功能性dyrkp‑1基因的绿色微藻在增加原料产量中的应用
CN107144620A (zh) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 糖尿病肾病检测标志物
CN107179309A (zh) * 2017-05-22 2017-09-19 厦门大学 一种精氨酸激酶的检测方法
CN108291867A (zh) * 2015-07-01 2018-07-17 曼塔仪器股份有限公司 用于液体中纳米颗粒的显微观察的专用试管组件和方法
CN108982826A (zh) * 2018-09-28 2018-12-11 广东工业大学 一种斑马鱼检测纳米颗粒对胚胎毒性的测试装置和测试方法
CN110327996A (zh) * 2019-09-03 2019-10-15 中国科学院上海高等研究院 微流控芯片、微流控系统及红外微流控分析方法
TWI695151B (zh) * 2012-11-30 2020-06-01 美商凱特伊夫公司 氣體包體系統
CN112626200A (zh) * 2021-01-12 2021-04-09 复旦大学附属妇产科医院 血清微囊泡-天冬酰胺内肽酶假基因1在子宫内膜异位症诊断及复发预测中的用途
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
CA2798812A1 (en) * 2010-05-21 2011-11-24 Ohmx Corporation Detection of cancer by assaying psa enzymatic activity
EP2686154B1 (en) * 2011-03-15 2018-11-14 National Research Council of Canada Microfluidic system having monolithic nanoplasmonic structures
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
KR102114734B1 (ko) 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
EP2878373A1 (en) 2013-11-29 2015-06-03 IMEC vzw Capillary flow plasmonic sensor
KR101626045B1 (ko) * 2014-07-29 2016-06-01 경희대학교 산학협력단 눈물 방울을 이용한 바이러스 감염진단 방법 및 기기
JP6441172B2 (ja) * 2015-06-12 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
JP6441174B2 (ja) * 2015-06-18 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN109313137A (zh) 2016-07-22 2019-02-05 惠普发展公司，有限责任合伙企业 衬底支撑的表面增强发光台和壳体
CA3091774A1 (en) * 2018-02-20 2019-08-29 EMULATE, Inc. Human microphysiological cell system for liver disease conversion with prov 1-18585 and prov 2-19154
US20210404967A1 (en) * 2018-12-14 2021-12-30 Hewlett-Packard Development Company, L.P. An analysis chip
DE102019100256A1 (de) 2019-01-07 2020-07-09 Als Automated Lab Solutions Gmbh Probengefäß mit einer Kavität zur Aufnahme einer Probe
GB2582619A (en) * 2019-03-28 2020-09-30 Sumitomo Chemical Co Enzyme linked assay methods and apparatuses
US12222316B2 (en) 2021-01-26 2025-02-11 IceMos Technology Limited Semiconductor device providing a biosensor to test for pathogen
US20220236261A1 (en) * 2021-01-26 2022-07-28 IceMos Technology Limited Semiconductor Device Providing a Biosensor to Test for Pathogen
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JPWO2023106372A1 (https=) * 2021-12-08 2023-06-15
WO2025163244A1 (en) * 2024-01-29 2025-08-07 Oulun Yliopisto Protein detection apparatus and method
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Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69735445T2 (de) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
US20040005582A1 (en) * 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
US7033910B2 (en) * 2001-09-12 2006-04-25 Reveo, Inc. Method of fabricating multi layer MEMS and microfluidic devices
US7795388B2 (en) * 2001-11-08 2010-09-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration (Nasa) Versatile platform for nanotechnology based on circular permutations of chaperonin protein
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
AU2003267583A1 (en) * 2002-09-19 2004-04-08 The Chancellor, Master And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
US7138330B2 (en) * 2002-09-27 2006-11-21 Medtronic Minimed, Inc. High reliability multilayer circuit substrates and methods for their formation
US6975402B2 (en) * 2002-11-19 2005-12-13 Sandia National Laboratories Tunable light source for use in photoacoustic spectrometers
US20060068412A1 (en) * 2004-03-05 2006-03-30 Cha-Mei Tang Integrated multistep bioprocessor and sensor
KR101168654B1 (ko) * 2004-05-19 2012-07-25 브이피 호울딩 엘엘씨 표면 증강 라만 산란에 의한 화학기의 증강된 검출을 위한 층상의 플라즈몬 구조를 가진 광센서
US20060046277A1 (en) * 2004-09-01 2006-03-02 Belyaev Alexander S Protein kinase and phosphatase substrates and multiplex assays for identifying their activities
US20060115536A1 (en) * 2004-11-12 2006-06-01 Board Of Regents, The University Of Texas System Glycerin based synthesis of silver nanoparticles and nanowires
DK1946083T3 (da) * 2005-10-17 2011-09-19 Sword Diagnostics Inc Fremgangsmåde til detektion af biologiske organismer under anvendelse af ramanspredning
GB0606088D0 (en) * 2006-03-27 2006-05-03 E2V Biosensors Ltd Improved serrs substrate

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103718038A (zh) * 2011-05-29 2014-04-09 韩国化学研究院 高速的基于拉曼分析的多药物高速筛选装置
TWI695151B (zh) * 2012-11-30 2020-06-01 美商凱特伊夫公司 氣體包體系統
CN105143858A (zh) * 2013-03-14 2015-12-09 惠普发展公司，有限责任合伙企业 用来检测物质的器件和产生这样的器件的方法
WO2015010545A1 (zh) * 2013-07-25 2015-01-29 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
US9778175B2 (en) 2013-07-25 2017-10-03 Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences High-sensitivity terahertz micro-fluidic channel sensor and preparation method thereof
CN106574231A (zh) * 2014-05-07 2017-04-19 原子能和替代能源委员会 缺少功能性dyrkp‑1基因的绿色微藻在增加原料产量中的应用
CN106574231B (zh) * 2014-05-07 2020-12-22 原子能和替代能源委员会 缺少功能性dyrkp-1基因的绿色微藻在增加原料产量中的应用
CN105100560A (zh) * 2014-05-21 2015-11-25 东和株式会社 电子零件封装体侧面摄影装置
CN104880391A (zh) * 2015-06-23 2015-09-02 好来化工(中山)有限公司 用于检测唾液中颗粒物质的装置
CN108291867A (zh) * 2015-07-01 2018-07-17 曼塔仪器股份有限公司 用于液体中纳米颗粒的显微观察的专用试管组件和方法
CN107144620A (zh) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 糖尿病肾病检测标志物
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