CN101970402B - 吡咯烷化合物 - Google Patents
吡咯烷化合物 Download PDFInfo
- Publication number
- CN101970402B CN101970402B CN2009801079412A CN200980107941A CN101970402B CN 101970402 B CN101970402 B CN 101970402B CN 2009801079412 A CN2009801079412 A CN 2009801079412A CN 200980107941 A CN200980107941 A CN 200980107941A CN 101970402 B CN101970402 B CN 101970402B
- Authority
- CN
- China
- Prior art keywords
- compound
- alkyl
- substituted
- group
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC*C(*)(*(C)*C(*)(*)C(C)(C)C(C)(*)*(C)C(*)=O)*(C)C(N(CC(C1)F)C1C#N)=O Chemical compound CC*C(*)(*(C)*C(*)(*)C(C)(C)C(C)(*)*(C)C(*)=O)*(C)C(N(CC(C1)F)C1C#N)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3387708P | 2008-03-05 | 2008-03-05 | |
| US61/033,877 | 2008-03-05 | ||
| PCT/US2009/035111 WO2009111239A2 (en) | 2008-03-05 | 2009-02-25 | Pyrrolidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101970402A CN101970402A (zh) | 2011-02-09 |
| CN101970402B true CN101970402B (zh) | 2013-12-18 |
Family
ID=41054296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801079412A Active CN101970402B (zh) | 2008-03-05 | 2009-02-25 | 吡咯烷化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8022096B2 (enExample) |
| EP (1) | EP2252582B1 (enExample) |
| JP (1) | JP5586484B2 (enExample) |
| KR (1) | KR101634656B1 (enExample) |
| CN (1) | CN101970402B (enExample) |
| AU (1) | AU2009222198B2 (enExample) |
| BR (1) | BRPI0906094B8 (enExample) |
| CA (1) | CA2717518C (enExample) |
| ES (1) | ES2515194T3 (enExample) |
| MY (1) | MY155630A (enExample) |
| NZ (1) | NZ587911A (enExample) |
| RU (1) | RU2494094C2 (enExample) |
| TW (1) | TWI385163B (enExample) |
| WO (1) | WO2009111239A2 (enExample) |
| ZA (1) | ZA201006329B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| US9849077B2 (en) | 2014-03-10 | 2017-12-26 | Mary Kay Inc. | Skin lightening compositions |
| CN104447479B (zh) * | 2015-01-13 | 2016-03-23 | 佛山市赛维斯医药科技有限公司 | 含金刚烷和酰胺类衍生物、其制备方法和用途 |
| CN104447478B (zh) * | 2015-01-13 | 2016-04-13 | 佛山市赛维斯医药科技有限公司 | 一种含腈基金刚烷和酰胺结构的衍生物、其制备方法和用途 |
| CN104496877B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种腈基金刚烷酰胺衍生物、其制备方法和用途 |
| CN104478778B (zh) * | 2015-01-13 | 2016-03-16 | 佛山市赛维斯医药科技有限公司 | 金刚烷酰胺类衍生物、其制备方法和用途 |
| CN104529855B (zh) * | 2015-01-13 | 2016-04-13 | 佛山市赛维斯医药科技有限公司 | 一种含羟基金刚烷和酰胺结构的衍生物、其制备方法和用途 |
| ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
| WO2021136491A1 (zh) * | 2019-12-31 | 2021-07-08 | 石药集团中奇制药技术（石家庄）有限公司 | 一种二肽基肽酶iv抑制剂的晶型及其制备方法和用途 |
| CN114641277B (zh) * | 2019-12-31 | 2023-06-13 | 石药集团中奇制药技术（石家庄）有限公司 | 一种二肽基肽酶4抑制剂的药物组合物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735605A (zh) * | 2002-11-07 | 2006-02-15 | 麦克公司 | 苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病 |
| CN1942186A (zh) * | 2004-03-09 | 2007-04-04 | 国家卫生研究院 | 吡咯烷化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021690A1 (en) | 1995-11-28 | 1997-06-19 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
| JP2000264882A (ja) * | 1999-03-18 | 2000-09-26 | Nippon Shokubai Co Ltd | 有機アミド化合物およびその製造方法 |
| GB9928330D0 (en) * | 1999-11-30 | 2000-01-26 | Ferring Bv | Novel antidiabetic agents |
| TWI243162B (en) | 2000-11-10 | 2005-11-11 | Taisho Pharmaceutical Co Ltd | Cyanopyrrolidine derivatives |
| US6861440B2 (en) | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
| EP1562925B1 (en) * | 2002-11-07 | 2007-01-03 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| JP2004203526A (ja) | 2002-12-24 | 2004-07-22 | Sharp Corp | 記録装置 |
| EP1595866B1 (en) | 2003-01-31 | 2016-06-08 | Sanwa Kagaku Kenkyusho Co., Ltd. | Cyanopyrrolidines useful for the treatment of inter alia metabolic syndrome |
| WO2004103993A1 (en) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| US20070093492A1 (en) * | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
| EP1760076A1 (en) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
-
2009
- 2009-02-25 KR KR1020107021993A patent/KR101634656B1/ko active Active
- 2009-02-25 CA CA2717518A patent/CA2717518C/en active Active
- 2009-02-25 WO PCT/US2009/035111 patent/WO2009111239A2/en not_active Ceased
- 2009-02-25 EP EP09718154.9A patent/EP2252582B1/en active Active
- 2009-02-25 ES ES09718154.9T patent/ES2515194T3/es active Active
- 2009-02-25 CN CN2009801079412A patent/CN101970402B/zh active Active
- 2009-02-25 MY MYPI2010004155A patent/MY155630A/en unknown
- 2009-02-25 BR BRPI0906094A patent/BRPI0906094B8/pt active IP Right Grant
- 2009-02-25 AU AU2009222198A patent/AU2009222198B2/en active Active
- 2009-02-25 US US12/392,590 patent/US8022096B2/en active Active
- 2009-02-25 NZ NZ587911A patent/NZ587911A/en unknown
- 2009-02-25 RU RU2010140627/04A patent/RU2494094C2/ru active
- 2009-02-25 JP JP2010549729A patent/JP5586484B2/ja active Active
- 2009-03-03 TW TW098106781A patent/TWI385163B/zh active
-
2010
- 2010-09-03 ZA ZA2010/06329A patent/ZA201006329B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735605A (zh) * | 2002-11-07 | 2006-02-15 | 麦克公司 | 苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病 |
| CN1942186A (zh) * | 2004-03-09 | 2007-04-04 | 国家卫生研究院 | 吡咯烷化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2252582A2 (en) | 2010-11-24 |
| HK1149261A1 (en) | 2011-09-30 |
| TW200938530A (en) | 2009-09-16 |
| US20090227569A1 (en) | 2009-09-10 |
| KR101634656B1 (ko) | 2016-06-29 |
| NZ587911A (en) | 2012-02-24 |
| WO2009111239A3 (en) | 2009-10-29 |
| KR20100129754A (ko) | 2010-12-09 |
| ZA201006329B (en) | 2011-05-25 |
| ES2515194T3 (es) | 2014-10-29 |
| AU2009222198B2 (en) | 2014-05-08 |
| RU2010140627A (ru) | 2012-04-10 |
| BRPI0906094B1 (pt) | 2019-11-12 |
| US8022096B2 (en) | 2011-09-20 |
| WO2009111239A2 (en) | 2009-09-11 |
| AU2009222198A1 (en) | 2009-09-11 |
| JP5586484B2 (ja) | 2014-09-10 |
| MY155630A (en) | 2015-11-13 |
| RU2494094C2 (ru) | 2013-09-27 |
| CN101970402A (zh) | 2011-02-09 |
| BRPI0906094B8 (pt) | 2021-05-25 |
| EP2252582B1 (en) | 2014-07-23 |
| CA2717518A1 (en) | 2009-09-11 |
| JP2011513410A (ja) | 2011-04-28 |
| BRPI0906094A2 (pt) | 2016-07-05 |
| EP2252582A4 (en) | 2012-03-07 |
| CA2717518C (en) | 2017-03-21 |
| TWI385163B (zh) | 2013-02-11 |
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Application publication date: 20110209 Assignee: GENOVATE BIOTECHNOLOGY Co.,Ltd. Assignor: National Health Research Institutes Contract record no.: 2014990000046 Denomination of invention: 2-alkylpyrrolidines Granted publication date: 20131218 License type: Exclusive License Record date: 20140123 |
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Application publication date: 20110209 Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) Co.,Ltd. Assignor: GENOVATE BIOTECHNOLOGY Co.,Ltd. Contract record no.: 2015990000769 Denomination of invention: 2-alkylpyrrolidines Granted publication date: 20131218 License type: Common License Record date: 20150827 |
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Application publication date: 20110209 Assignee: CSPC PHARMACEUTICAL GROUP OUYI PHARMA Co.,Ltd. Assignor: GENOVATE BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2023990000315 Denomination of invention: Pyrrolidine compounds Granted publication date: 20131218 License type: Common License Record date: 20230324 |
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