CN101951939B - 通过对接和锁定(dnl)技术的聚乙二醇化 - Google Patents

通过对接和锁定(dnl)技术的聚乙二醇化 Download PDF

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CN101951939B
CN101951939B CN2008801133361A CN200880113336A CN101951939B CN 101951939 B CN101951939 B CN 101951939B CN 2008801133361 A CN2008801133361 A CN 2008801133361A CN 200880113336 A CN200880113336 A CN 200880113336A CN 101951939 B CN101951939 B CN 101951939B
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ddd
peg
complex
antibody
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CN101951939A (zh
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W·麦克布莱德
C-H·张
E·罗希
D·高德伯格
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IBC Pharmaceuticals Inc
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CN2008801133361A 2007-10-26 2008-10-24 通过对接和锁定(dnl)技术的聚乙二醇化 Active CN101951939B (zh)

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Application Number Priority Date Filing Date Title
US11/925,408 2007-10-26
US11/925,408 US7666400B2 (en) 2005-04-06 2007-10-26 PEGylation by the dock and lock (DNL) technique
PCT/US2008/081085 WO2009055653A1 (en) 2007-10-26 2008-10-24 Pegylation by the dock and lock (dnl) technique

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CN101951939A CN101951939A (zh) 2011-01-19
CN101951939B true CN101951939B (zh) 2013-11-20

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US (5) US7666400B2 (https=)
EP (1) EP2197468B1 (https=)
JP (2) JP5577558B2 (https=)
KR (1) KR101583388B1 (https=)
CN (1) CN101951939B (https=)
AU (1) AU2008316741B9 (https=)
CA (1) CA2696160C (https=)
IL (1) IL204066A (https=)
MX (1) MX2010004547A (https=)
WO (1) WO2009055653A1 (https=)

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US7534866B2 (en) * 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
US7666400B2 (en) * 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
US7550143B2 (en) * 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US7052686B2 (en) 2000-09-29 2006-05-30 Schering Corporation Pegylated interleukin-10
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