MX2010004547A - Pegilacion por la tecnica de acoplamiento y bloqueo (dnl). - Google Patents

Pegilacion por la tecnica de acoplamiento y bloqueo (dnl).

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Publication number
MX2010004547A
MX2010004547A MX2010004547A MX2010004547A MX2010004547A MX 2010004547 A MX2010004547 A MX 2010004547A MX 2010004547 A MX2010004547 A MX 2010004547A MX 2010004547 A MX2010004547 A MX 2010004547A MX 2010004547 A MX2010004547 A MX 2010004547A
Authority
MX
Mexico
Prior art keywords
sequence
peg
moiety
pegylated
effector
Prior art date
Application number
MX2010004547A
Other languages
English (en)
Inventor
William Mcbride
Chien-Hsing Chang
Edmund Rossi
David Goldenberg
Original Assignee
Ibc Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ibc Pharmaceuticals Inc filed Critical Ibc Pharmaceuticals Inc
Publication of MX2010004547A publication Critical patent/MX2010004547A/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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Abstract

La presente invenci6n describe métodos y composiciones para formar complejos PEGilados de estequiometria y estructura definidos. En modalidades preteridas, el complejo PEGilado se forma usando tecnología de acoplamiento y bloqueo, al unir un radical efector a una secuencia DDD y unir un radical PEG a una secuencia AD y que permite que la secuencia DDD se una a la secuencia AD en una estequiometría 2:1, para formar complejos PEGilados con dos radicales efectores de un radical PEG. En modalidades alternativas, el radical efector se puede unir a la secuencia AD y el PEG a la secuencia DDD para formar complejos PEGilados con dos radicales PEG y un radical efector. En modalidades más preferidas, el radical efector puede comprender cualquier péptido o proteína de actividad fisiológica o terapéutica. Los complejos PEGilados exhiben una velocidad significantemente menor de evacuación cuando se inyecta en un sujeto y son de uso para el tratamiento de una amplia variedad de enfermedades.
MX2010004547A 2007-10-26 2008-10-24 Pegilacion por la tecnica de acoplamiento y bloqueo (dnl). MX2010004547A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/925,408 US7666400B2 (en) 2005-04-06 2007-10-26 PEGylation by the dock and lock (DNL) technique
PCT/US2008/081085 WO2009055653A1 (en) 2007-10-26 2008-10-24 Pegylation by the dock and lock (dnl) technique

Publications (1)

Publication Number Publication Date
MX2010004547A true MX2010004547A (es) 2010-07-05

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MX2010004547A MX2010004547A (es) 2007-10-26 2008-10-24 Pegilacion por la tecnica de acoplamiento y bloqueo (dnl).

Country Status (11)

Country Link
US (5) US7666400B2 (es)
EP (1) EP2197468B1 (es)
JP (2) JP5577558B2 (es)
KR (1) KR101583388B1 (es)
CN (1) CN101951939B (es)
AU (1) AU2008316741B9 (es)
CA (1) CA2696160C (es)
HK (1) HK1148471A1 (es)
IL (1) IL204066A (es)
MX (1) MX2010004547A (es)
WO (1) WO2009055653A1 (es)

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US7666400B2 (en) * 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
US7550143B2 (en) * 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US7534866B2 (en) * 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
EP1324779B1 (en) 2000-09-29 2011-07-20 Schering Corporation Pegylated interleukin-10
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
US7906118B2 (en) 2005-04-06 2011-03-15 Ibc Pharmaceuticals, Inc. Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology
US20110020273A1 (en) * 2005-04-06 2011-01-27 Ibc Pharmaceuticals, Inc. Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof
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