CN101938993A - 包括纳米粒子的植入式产品 - Google Patents
包括纳米粒子的植入式产品 Download PDFInfo
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- CN101938993A CN101938993A CN2009801043533A CN200980104353A CN101938993A CN 101938993 A CN101938993 A CN 101938993A CN 2009801043533 A CN2009801043533 A CN 2009801043533A CN 200980104353 A CN200980104353 A CN 200980104353A CN 101938993 A CN101938993 A CN 101938993A
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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| US7108408P | 2008-04-11 | 2008-04-11 | |
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| PCT/DE2009/000196 WO2009100716A2 (de) | 2008-02-11 | 2009-02-11 | Implantierbare nanopartikel-enthaltende produkte |
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| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| RU189268U1 (ru) * | 2019-03-22 | 2019-05-17 | Артем Олегович Бахметьев | Акупунктурная игла |
| RU189308U1 (ru) * | 2019-03-22 | 2019-05-21 | Артем Олегович Бахметьев | Трансдермальный пластырь |
| KR102372213B1 (ko) * | 2019-09-09 | 2022-03-08 | 한국화학연구원 | 히알루론산 또는 그의 염 및 폴리페놀 화합물을 포함하는 수분해성 필름 |
| JP2022549270A (ja) | 2019-09-23 | 2022-11-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | バイオマテリアルベースの無抗原ワクチンおよびその使用 |
| EP4096624A1 (en) | 2020-01-31 | 2022-12-07 | MagForce AG | Paste comprising magnetic alkoxysilane-coated metal containing nanoparticles |
| CN112972779B (zh) * | 2021-02-05 | 2022-07-12 | 武汉磁济科技有限公司 | 一种植入式柔性磁响应人工膀胱基体及其制造方法 |
| CN112933288B (zh) * | 2021-02-08 | 2022-02-22 | 四川大学 | 兼具止血和术后抗肿瘤功能的交联止血海绵及其制备方法 |
| US20230061188A1 (en) * | 2021-08-30 | 2023-03-02 | Apple Inc. | Enhanced mems sensor embedded heater |
| DE102022115394A1 (de) | 2022-06-21 | 2023-12-21 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Implantat und Anordnung aufweisend eine Strahlungsquelle und ein Implantat |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31064A (en) * | 1990-09-07 | 1998-02-05 | Nycomed As Of Nycoveten | Polymers containing diester units. |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| DE4428851C2 (de) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| DE19614136A1 (de) | 1996-04-10 | 1997-10-16 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug |
| JPH10328314A (ja) * | 1997-06-02 | 1998-12-15 | Nippon Electric Glass Co Ltd | 温熱治療用セメント材料及び温熱治療用インプラント材 |
| JPH10337335A (ja) * | 1997-06-06 | 1998-12-22 | Nippon Electric Glass Co Ltd | 温熱治療用インプラント材 |
| DE19726282A1 (de) | 1997-06-20 | 1998-12-24 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| US6267782B1 (en) * | 1997-11-20 | 2001-07-31 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
| WO2001005586A1 (en) * | 1999-07-16 | 2001-01-25 | Wm. Marsh Rice University | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
| DE10059151C2 (de) | 2000-11-29 | 2003-10-16 | Christoph Alexiou | Magnetische Partikel zur zielgerichteten regionalen Therapie und Verwendung derselben |
| US6527693B2 (en) * | 2001-01-30 | 2003-03-04 | Implant Sciences Corporation | Methods and implants for providing radiation to a patient |
| CA2481020A1 (en) | 2001-09-28 | 2003-04-03 | Saoirse Corporation | Localized non-invasive biological modulation system |
| DE10164309A1 (de) * | 2001-12-28 | 2003-07-10 | Fraunhofer Ges Forschung | Verbesserte strukturiert-funktionale Bindematrices für Biomoleküle |
| WO2003092791A2 (en) * | 2002-05-02 | 2003-11-13 | Scimed Life Systems, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
| US20040136905A1 (en) * | 2002-10-15 | 2004-07-15 | Kent Thomas B. | Magnetically guided particles for radiative therapies |
| ITTO20020994A1 (it) * | 2002-11-15 | 2004-05-16 | Torino Politecnico | Materiali magnetici biocompatibili per il trattamento del cancro mediante ipertermia, e processi per la loro realizzazione. |
| DE10350248A1 (de) | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
| US20070196281A1 (en) | 2003-12-31 | 2007-08-23 | Sungho Jin | Method and articles for remote magnetically induced treatment of cancer and other diseases, and method for operating such article |
| WO2005070471A2 (en) | 2004-01-20 | 2005-08-04 | Alnis Biosciences, Inc. | Articles comprising magnetic material and bioactive agents |
| CN101010004B (zh) * | 2004-07-30 | 2012-10-03 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| US20070243255A1 (en) | 2004-09-28 | 2007-10-18 | Bing Xu | Multifunctional supramolecular hydrogels as biomaterials |
| DE102005016873A1 (de) * | 2005-04-12 | 2006-10-19 | Magforce Nanotechnologies Ag | Nanopartikel-Wirstoff-Konjugate |
| EP1883425A1 (en) * | 2005-05-23 | 2008-02-06 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| FR2889449B1 (fr) | 2005-08-05 | 2011-06-10 | Khorionyx | Preparations implantables |
| DE102005039579B4 (de) | 2005-08-19 | 2022-06-30 | Magforce Ag | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| WO2007095454A2 (en) * | 2006-02-10 | 2007-08-23 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Carbon-encased metal nanoparticles and sponges, methods of synthesis, and methods of use |
| WO2008089478A2 (en) * | 2007-01-19 | 2008-07-24 | Triton Biosystems, Inc. | Thermotherapy susceptors and methods of using same |
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2008
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013017069A1 (zh) * | 2011-08-02 | 2013-02-07 | 微创医疗器械(上海)有限公司 | 一种带凹槽的生物可降解支架及其制备方法 |
| CN102379762A (zh) * | 2011-08-02 | 2012-03-21 | 微创医疗器械(上海)有限公司 | 一种带凹槽的生物可降解支架及其制备方法 |
| CN102379762B (zh) * | 2011-08-02 | 2015-03-25 | 上海微创医疗器械(集团)有限公司 | 一种带凹槽的生物可降解支架及其制备方法 |
| CN103203903A (zh) * | 2013-03-25 | 2013-07-17 | 海龙核材科技(江苏)有限公司 | 一种电场磁场下响应的传感材料及其制备方法 |
| CN105339005A (zh) * | 2013-06-04 | 2016-02-17 | 福姆迪卡股份公司 | 在癌症治疗中用于与放射治疗组合的细胞毒性物质 |
| CN103752849B (zh) * | 2014-02-13 | 2016-02-24 | 华东理工大学 | 制备稳定纳米银的方法 |
| CN103752849A (zh) * | 2014-02-13 | 2014-04-30 | 华东理工大学 | 制备稳定纳米银的方法 |
| CN108463256A (zh) * | 2015-09-04 | 2018-08-28 | 约翰内斯堡威特沃特斯兰德大学 | 生物可降解的植入物 |
| CN108463256B (zh) * | 2015-09-04 | 2021-04-16 | 约翰内斯堡威特沃特斯兰德大学 | 生物可降解的植入物 |
| CN108912628A (zh) * | 2018-05-31 | 2018-11-30 | 苏州乔纳森新材料科技有限公司 | 一种插管用抗菌纳米材料的制备方法 |
| CN111921003A (zh) * | 2020-09-04 | 2020-11-13 | 东南大学 | 一种磁响应热疗可控降解栓塞微球及其制备方法与应用 |
| CN111921003B (zh) * | 2020-09-04 | 2022-06-03 | 东南大学 | 一种磁响应热疗可控降解栓塞微球及其制备方法与应用 |
| CN112972778A (zh) * | 2021-02-05 | 2021-06-18 | 华中科技大学 | 一种人工膀胱铁磁复合物及其制备方法 |
| CN112972778B (zh) * | 2021-02-05 | 2022-05-27 | 华中科技大学 | 一种人工膀胱铁磁复合物及其制备方法 |
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| Publication number | Publication date |
|---|---|
| AU2009214533B2 (en) | 2015-01-29 |
| ES2619509T3 (es) | 2017-06-26 |
| US20110223255A1 (en) | 2011-09-15 |
| WO2009100716A2 (de) | 2009-08-20 |
| JP5649455B2 (ja) | 2015-01-07 |
| KR20100117602A (ko) | 2010-11-03 |
| IL207137A (en) | 2015-02-26 |
| RU2524644C2 (ru) | 2014-07-27 |
| EP2249804A2 (de) | 2010-11-17 |
| DE102008008522A1 (de) | 2009-08-13 |
| PT2249804T (pt) | 2017-03-20 |
| RU2010136311A (ru) | 2012-03-20 |
| WO2009100716A3 (de) | 2010-09-23 |
| IL207137A0 (en) | 2010-12-30 |
| BRPI0906611A8 (pt) | 2019-01-29 |
| AU2009214533A1 (en) | 2009-08-20 |
| BRPI0906611A2 (pt) | 2015-07-14 |
| SG188146A1 (en) | 2013-03-28 |
| PL2249804T3 (pl) | 2017-07-31 |
| CA2712832A1 (en) | 2009-08-20 |
| DK2249804T3 (en) | 2017-02-27 |
| DE112009000905A5 (de) | 2011-01-20 |
| JP2011511684A (ja) | 2011-04-14 |
| CA2712832C (en) | 2016-05-17 |
| EP2249804B1 (de) | 2016-12-14 |
| KR101581973B1 (ko) | 2015-12-31 |
| MX2010008806A (es) | 2010-12-21 |
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