JP2011511684A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011511684A5 JP2011511684A5 JP2010546211A JP2010546211A JP2011511684A5 JP 2011511684 A5 JP2011511684 A5 JP 2011511684A5 JP 2010546211 A JP2010546211 A JP 2010546211A JP 2010546211 A JP2010546211 A JP 2010546211A JP 2011511684 A5 JP2011511684 A5 JP 2011511684A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- medical product
- tumor
- poly
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940127554 medical product Drugs 0.000 claims 42
- -1 cytotoxic Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 239000006249 magnetic particle Substances 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 3
- 230000005291 magnetic effect Effects 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229920001296 polysiloxane Polymers 0.000 claims 3
- 229920002635 polyurethane Polymers 0.000 claims 3
- 239000004814 polyurethane Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 2
- 108010092160 Dactinomycin Proteins 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 229920002943 EPDM rubber Polymers 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229920000297 Rayon Polymers 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 229920002494 Zein Polymers 0.000 claims 2
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000000824 cytostatic agent Substances 0.000 claims 2
- 230000001085 cytostatic effect Effects 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 239000004744 fabric Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 210000001595 mastoid Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000005962 mycosis fungoides Diseases 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002964 rayon Substances 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 239000005019 zein Substances 0.000 claims 2
- 229940093612 zein Drugs 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- JPMICTZIAZZHCD-AKGZTFGVSA-N (2s)-2-amino-4-ethylpentanedioic acid Chemical compound CCC(C(O)=O)C[C@H](N)C(O)=O JPMICTZIAZZHCD-AKGZTFGVSA-N 0.000 claims 1
- FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims 1
- ZNLAHAOCFKBYRH-UHFFFAOYSA-N 1,4-dioxane-2,3-dione Chemical compound O=C1OCCOC1=O ZNLAHAOCFKBYRH-UHFFFAOYSA-N 0.000 claims 1
- KHEDIYCQDPMFKF-UHFFFAOYSA-N 2-(sulfooxy)acetic acid Chemical compound OC(=O)COS(O)(=O)=O KHEDIYCQDPMFKF-UHFFFAOYSA-N 0.000 claims 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 1
- 102000015790 Asparaginase Human genes 0.000 claims 1
- 108010024976 Asparaginase Proteins 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 229930185605 Bisphenol Natural products 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 108010006654 Bleomycin Proteins 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 108010037003 Buserelin Proteins 0.000 claims 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
- 229920002284 Cellulose triacetate Chemical class 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000009738 Connective Tissue Neoplasms Diseases 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000009129 Ear Neoplasms Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000004413 Eyelid Neoplasms Diseases 0.000 claims 1
- 206010050497 Eyelid tumour Diseases 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 1
- 108010069236 Goserelin Proteins 0.000 claims 1
- 229920002971 Heparan sulfate Polymers 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 108010000817 Leuprolide Proteins 0.000 claims 1
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 229930192392 Mitomycin Natural products 0.000 claims 1
- 229940121849 Mitotic inhibitor Drugs 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000010505 Nose Neoplasms Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920002614 Polyether block amide Polymers 0.000 claims 1
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 206010062129 Tongue neoplasm Diseases 0.000 claims 1
- 108010050144 Triptorelin Pamoate Proteins 0.000 claims 1
- 206010046431 Urethral cancer Diseases 0.000 claims 1
- 206010046458 Urethral neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical class O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims 1
- 229930183665 actinomycin Natural products 0.000 claims 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229960003437 aminoglutethimide Drugs 0.000 claims 1
- ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 claims 1
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 claims 1
- 229960001220 amsacrine Drugs 0.000 claims 1
- 229960002932 anastrozole Drugs 0.000 claims 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940046836 anti-estrogen Drugs 0.000 claims 1
- 230000001833 anti-estrogenic effect Effects 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 230000002095 anti-migrative effect Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 229940046844 aromatase inhibitors Drugs 0.000 claims 1
- 229960003272 asparaginase Drugs 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims 1
- 229960002938 bexarotene Drugs 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 238000006065 biodegradation reaction Methods 0.000 claims 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 claims 1
- 229960001561 bleomycin Drugs 0.000 claims 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 1
- 229960002719 buserelin Drugs 0.000 claims 1
- 229960002092 busulfan Drugs 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229960004117 capecitabine Drugs 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 208000002458 carcinoid tumor Diseases 0.000 claims 1
- 229960005243 carmustine Drugs 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 claims 1
- 229920001727 cellulose butyrate Polymers 0.000 claims 1
- 229920003086 cellulose ether Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
- 229960004630 chlorambucil Drugs 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 229960002436 cladribine Drugs 0.000 claims 1
- 210000000860 cochlear nerve Anatomy 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960000684 cytarabine Drugs 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 229960003901 dacarbazine Drugs 0.000 claims 1
- 229960000640 dactinomycin Drugs 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 239000003822 epoxy resin Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229960001842 estramustine Drugs 0.000 claims 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960000255 exemestane Drugs 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 229920002313 fluoropolymer Polymers 0.000 claims 1
- 239000004811 fluoropolymer Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 239000004052 folic acid antagonist Substances 0.000 claims 1
- 229960004421 formestane Drugs 0.000 claims 1
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 239000007863 gel particle Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960002913 goserelin Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 239000003667 hormone antagonist Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229960000908 idarubicin Drugs 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
- 229960004338 leuprorelin Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 229960002247 lomustine Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 208000016847 malignant urinary system neoplasm Diseases 0.000 claims 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
- 229960001924 melphalan Drugs 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910001092 metal group alloy Inorganic materials 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960003775 miltefosine Drugs 0.000 claims 1
- PQLXHQMOHUQAKB-UHFFFAOYSA-N miltefosine Chemical compound CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C PQLXHQMOHUQAKB-UHFFFAOYSA-N 0.000 claims 1
- 229960004857 mitomycin Drugs 0.000 claims 1
- 230000011278 mitosis Effects 0.000 claims 1
- 229960001156 mitoxantrone Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 208000037830 nasal cancer Diseases 0.000 claims 1
- 230000009826 neoplastic cell growth Effects 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 claims 1
- 229960001420 nimustine Drugs 0.000 claims 1
- 229920001220 nitrocellulos Polymers 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 229920003175 pectinic acid Polymers 0.000 claims 1
- 229960002340 pentostatin Drugs 0.000 claims 1
- FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 claims 1
- 208000010916 pituitary tumor Diseases 0.000 claims 1
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 claims 1
- 229920000141 poly(maleic anhydride) Polymers 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920002239 polyacrylonitrile Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920001707 polybutylene terephthalate Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920002721 polycyanoacrylate Polymers 0.000 claims 1
- 229920000647 polyepoxide Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 229920000151 polyglycol Polymers 0.000 claims 1
- 239000010695 polyglycol Substances 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 229950008885 polyglycolic acid Drugs 0.000 claims 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims 1
- 229920001721 polyimide Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920000098 polyolefin Polymers 0.000 claims 1
- 229920006124 polyolefin elastomer Polymers 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920006216 polyvinyl aromatic Polymers 0.000 claims 1
- 229920001290 polyvinyl ester Polymers 0.000 claims 1
- 229920001289 polyvinyl ether Polymers 0.000 claims 1
- 229920006215 polyvinyl ketone Polymers 0.000 claims 1
- 229920000131 polyvinylidene Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 claims 1
- 229960000624 procarbazine Drugs 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 208000014680 small intestine neoplasm Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960004964 temozolomide Drugs 0.000 claims 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims 1
- 229960001278 teniposide Drugs 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 229960001196 thiotepa Drugs 0.000 claims 1
- 208000008732 thymoma Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 229960003087 tioguanine Drugs 0.000 claims 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 claims 1
- 201000006134 tongue cancer Diseases 0.000 claims 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 1
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 claims 1
- 229960004824 triptorelin Drugs 0.000 claims 1
- UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 claims 1
- 229960000875 trofosfamide Drugs 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 201000004435 urinary system cancer Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 229960004355 vindesine Drugs 0.000 claims 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008008522A DE102008008522A1 (de) | 2008-02-11 | 2008-02-11 | Implantierbare Nanopartikel-enthaltende Produkte |
| DE102008008522.7 | 2008-02-11 | ||
| US7108408P | 2008-04-11 | 2008-04-11 | |
| US61/071,084 | 2008-04-11 | ||
| PCT/DE2009/000196 WO2009100716A2 (de) | 2008-02-11 | 2009-02-11 | Implantierbare nanopartikel-enthaltende produkte |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511684A JP2011511684A (ja) | 2011-04-14 |
| JP2011511684A5 true JP2011511684A5 (enExample) | 2013-04-11 |
| JP5649455B2 JP5649455B2 (ja) | 2015-01-07 |
Family
ID=40847365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546211A Active JP5649455B2 (ja) | 2008-02-11 | 2009-02-11 | ナノ粒子を含む移植可能な製品 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20110223255A1 (enExample) |
| EP (1) | EP2249804B1 (enExample) |
| JP (1) | JP5649455B2 (enExample) |
| KR (1) | KR101581973B1 (enExample) |
| CN (1) | CN101938993A (enExample) |
| AU (1) | AU2009214533B2 (enExample) |
| BR (1) | BRPI0906611A8 (enExample) |
| CA (1) | CA2712832C (enExample) |
| DE (2) | DE102008008522A1 (enExample) |
| DK (1) | DK2249804T3 (enExample) |
| ES (1) | ES2619509T3 (enExample) |
| IL (1) | IL207137A (enExample) |
| MX (1) | MX2010008806A (enExample) |
| PL (1) | PL2249804T3 (enExample) |
| PT (1) | PT2249804T (enExample) |
| RU (1) | RU2524644C2 (enExample) |
| SG (1) | SG188146A1 (enExample) |
| WO (1) | WO2009100716A2 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
| US20110165255A1 (en) * | 2008-09-04 | 2011-07-07 | Takeshi Kobayashi | Malignant tumor heat therapy kit comprising anti-regulatory t cell antibody and magnetic fine particles and heat therapy method thereof |
| JP5463531B2 (ja) * | 2009-07-22 | 2014-04-09 | 国立大学法人 東京大学 | Ｐｈｄ２発現抑制物質搭載ポリイオンコンプレックス |
| AU2010278702C1 (en) | 2009-07-31 | 2016-07-14 | Forsyth Dental Infirmary For Children | Programming of cells for tolerogenic therapies |
| EP2322142B1 (de) * | 2009-11-12 | 2016-07-27 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Biokompatible, magnetische Nanopartikel zur Behandlung von Glioblastomen |
| DE102009058769A1 (de) * | 2009-12-16 | 2011-06-22 | MagForce Nanotechnologies AG, 10589 | Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung |
| US20130089740A1 (en) * | 2010-06-29 | 2013-04-11 | Koninklijke Philips Electronics N.V. | Synthesis and use of iron oleate |
| JP5945540B2 (ja) | 2010-08-27 | 2016-07-05 | シエナ バイオファーマシューティカルズ，インク． | 標的とされた熱変調のための組成物及び方法 |
| US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
| HRP20200310T1 (hr) | 2010-10-06 | 2020-08-21 | President And Fellows Of Harvard College | Hidrogelovi koji stvaraju pore pogodni za injekcije, namijenjeni staničnim terapijama na bazi materijala |
| US8944067B2 (en) * | 2010-12-15 | 2015-02-03 | Kci Licensing, Inc. | Targeted delivery of magnetically tagged active agents in combination with negative pressure wound therapy |
| US9764157B2 (en) | 2011-01-17 | 2017-09-19 | University Of Utah Research Foundation | Methods, systems, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles |
| US10359552B2 (en) | 2011-01-17 | 2019-07-23 | University Of Utah Research Foundation | Methods, systems, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles |
| WO2012177296A1 (en) | 2011-01-17 | 2012-12-27 | University Of Utah Research Foundation | Apparatus and methods for reducing frequency or severity of photophobic responses or modulating circadian cycles |
| EP2683440B1 (de) | 2011-03-10 | 2015-11-04 | MagForce AG | Computergestütztes simulationswerkzeug zur unterstützung bei der planung einer thermotherapie |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| ES2685327T3 (es) | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
| US20140093572A1 (en) * | 2011-05-06 | 2014-04-03 | Ut-Battelle, Llc | Active materials for prevention and treatment of fouled surfaces |
| US9486512B2 (en) | 2011-06-03 | 2016-11-08 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| CN102379762B (zh) * | 2011-08-02 | 2015-03-25 | 上海微创医疗器械（集团）有限公司 | 一种带凹槽的生物可降解支架及其制备方法 |
| JP5844902B2 (ja) | 2011-08-10 | 2016-01-20 | マグフォース アーゲー | アルコキシシランでコーティングされた磁性ナノ粒子の凝集化 |
| JP6042450B2 (ja) | 2011-12-16 | 2016-12-14 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 金属材料および酸化ハフニウム材料を含むナノ粒子、その製造および使用 |
| ES2773895T3 (es) | 2012-04-16 | 2020-07-15 | Harvard College | Composiciones de sílice mesoporosa para modular las respuestas inmunitarias |
| DK2906286T3 (en) | 2012-10-11 | 2017-07-17 | Nanocomposix Inc | SILVER CHARACTER COMPOSITIONS AND PROCEDURES |
| WO2014085651A1 (en) * | 2012-11-29 | 2014-06-05 | The Johns Hopkins University | A process for making iron oxide nanoparticle preparations for cancer hyperthermia |
| US20140219926A1 (en) * | 2013-02-01 | 2014-08-07 | The Trustees Of Dartmouth College | Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy |
| WO2014124322A1 (en) | 2013-02-08 | 2014-08-14 | University Of Louisville Research Foundation, Inc. | Nanoparticles for drug delivery |
| CN103203903A (zh) * | 2013-03-25 | 2013-07-17 | 海龙核材科技（江苏）有限公司 | 一种电场磁场下响应的传感材料及其制备方法 |
| SG10201710056UA (en) * | 2013-06-04 | 2018-01-30 | Fumedica Ag | Cytotoxic substance for use in combination with radiotherapy in cancer treatment |
| AU2014283217A1 (en) * | 2013-06-20 | 2015-12-24 | Nanobiotix | Compositions and methods for use in medical diagnosis |
| EP2823858A1 (en) | 2013-07-12 | 2015-01-14 | Brossel, Rémy | System generating a constraint field, and medical device implementing the same |
| WO2015020936A1 (en) | 2013-08-06 | 2015-02-12 | Ut-Battelle, Llc | Local thermal actuation of material surfaces via micro- and nanowire heating for the prevention of cellular attachment and biological fouling |
| US10281627B2 (en) | 2013-11-15 | 2019-05-07 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| US10234608B2 (en) | 2013-11-15 | 2019-03-19 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| CN103752849B (zh) * | 2014-02-13 | 2016-02-24 | 华东理工大学 | 制备稳定纳米银的方法 |
| US9814631B2 (en) * | 2014-03-03 | 2017-11-14 | Sambhu Choudhury | Container for surgical absorbent articles |
| US20150297763A1 (en) | 2014-04-17 | 2015-10-22 | Boston Scientific Scimed, Inc. | Devices and methods for therapeutic heat treatment |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
| CN103989552B (zh) * | 2014-05-07 | 2015-10-28 | 江苏达胜伦比亚生物科技有限公司 | 一种医用水凝胶凉贴 |
| CZ27466U1 (cs) * | 2014-08-21 | 2014-11-10 | Univerzita Tomáše Bati ve Zlíně | Biomateriál na bázi hydrogelu citlivý na magnetické podněty |
| RU2616258C2 (ru) * | 2014-11-10 | 2017-04-13 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" | Способ получения полимерных наночастиц низкосиалированного эритропоэтина с высокой степенью сорбции для лечения неврологических заболеваний |
| WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
| JP2018516256A (ja) | 2015-05-28 | 2018-06-21 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 治療用ワクチンとしての使用のためのナノ粒子 |
| WO2017037685A1 (en) * | 2015-09-04 | 2017-03-09 | University Of The Witwatersrand, Johannesburg | Biodegradable implant |
| CN108289856A (zh) | 2015-10-07 | 2018-07-17 | 波士顿科学国际有限公司 | 用以提高热疗的感应加热效率的具有不同居里温度的LaFeSiH磁性纳米粒子混合物 |
| RU167739U1 (ru) * | 2015-12-02 | 2017-01-10 | Федеральное государственное бюджетное учреждение науки Красноярский научный центр Сибирского отделения Российской академии наук (ФГБУН КНЦ СО РАН) | Нанодиски для разрушения опухолевых клеток |
| WO2017136837A1 (en) | 2016-02-06 | 2017-08-10 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| AU2017295704B2 (en) | 2016-07-13 | 2023-07-13 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| CN110418651A (zh) | 2016-08-02 | 2019-11-05 | 哈佛学院院长等 | 用于调节免疫应答的生物材料 |
| JP6968887B2 (ja) * | 2016-09-08 | 2021-11-17 | シェーファー・カーク・ゲーエムベーハー・ウント・コンパニー・カーゲーSchaefer Kalk Gmbh & Co. Kg | 微細構造粒子を有するカルシウム塩含有複合粉末 |
| EP3305334A1 (en) * | 2016-10-06 | 2018-04-11 | Universitätsklinikum Jena | Magnetic composition and medical material for stimulating vascularisation in internal or external wound of the body |
| US10993910B2 (en) | 2016-12-07 | 2021-05-04 | Seoul National University R&Db Foundation | Biopatch, bioheater, biosensor and bioelectronic patch device |
| CZ307237B6 (cs) * | 2016-12-16 | 2018-04-18 | Synthesia, A. S. | Supramolekulární komplex oxycelulózové matrice s taxolovým derivátem s postupným uvolňováním taxolového derivátu a jeho použití |
| US20190350867A1 (en) * | 2016-12-27 | 2019-11-21 | Soon Kap Hahn | Prevention of local tumor recurrence following surgery using sustained and/or delayed release of medicaments contained in micro-particles |
| US12396951B2 (en) | 2016-12-27 | 2025-08-26 | Upexmed Co. Ltd. | Prevention of local tumor recurrence following surgery using sustainedand/or delayed release of medicaments contained in micro-particles |
| DE102017214576A1 (de) * | 2017-08-21 | 2019-02-21 | Universität Bielefeld | Anorganisch-organischer Nanokomposit mit zellbiologischer und sensorischer Aktivität |
| RU181004U1 (ru) * | 2017-11-14 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| RU181003U1 (ru) * | 2017-11-14 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| RU181002U1 (ru) * | 2017-12-25 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| KR102200787B1 (ko) * | 2017-12-29 | 2021-01-12 | 한경대학교 산학협력단 | 나노셀룰로오스를 이용한 습윤성 탄력붕대 |
| CN108912628A (zh) * | 2018-05-31 | 2018-11-30 | 苏州乔纳森新材料科技有限公司 | 一种插管用抗菌纳米材料的制备方法 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| JP2022514568A (ja) | 2018-12-17 | 2022-02-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫系のモジュレーションのための生物工学的スキャフォールドおよびその使用 |
| RU189268U1 (ru) * | 2019-03-22 | 2019-05-17 | Артем Олегович Бахметьев | Акупунктурная игла |
| RU189308U1 (ru) * | 2019-03-22 | 2019-05-21 | Артем Олегович Бахметьев | Трансдермальный пластырь |
| KR102372213B1 (ko) * | 2019-09-09 | 2022-03-08 | 한국화학연구원 | 히알루론산 또는 그의 염 및 폴리페놀 화합물을 포함하는 수분해성 필름 |
| JP2022549270A (ja) | 2019-09-23 | 2022-11-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | バイオマテリアルベースの無抗原ワクチンおよびその使用 |
| KR20220133893A (ko) | 2020-01-31 | 2022-10-05 | 매그포스 아게 | 자성 알콕시실란-코팅된 금속 함유 나노입자를 포함하는 페이스트 |
| CN111921003B (zh) * | 2020-09-04 | 2022-06-03 | 东南大学 | 一种磁响应热疗可控降解栓塞微球及其制备方法与应用 |
| CN112972779B (zh) * | 2021-02-05 | 2022-07-12 | 武汉磁济科技有限公司 | 一种植入式柔性磁响应人工膀胱基体及其制造方法 |
| CN112972778B (zh) * | 2021-02-05 | 2022-05-27 | 华中科技大学 | 一种人工膀胱铁磁复合物及其制备方法 |
| CN112933288B (zh) * | 2021-02-08 | 2022-02-22 | 四川大学 | 兼具止血和术后抗肿瘤功能的交联止血海绵及其制备方法 |
| US20230061188A1 (en) * | 2021-08-30 | 2023-03-02 | Apple Inc. | Enhanced mems sensor embedded heater |
| DE102022115394A1 (de) | 2022-06-21 | 2023-12-21 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Implantat und Anordnung aufweisend eine Strahlungsquelle und ein Implantat |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31064A (en) * | 1990-09-07 | 1998-02-05 | Nycomed As Of Nycoveten | Polymers containing diester units. |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| DE4428851C2 (de) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| DE19614136A1 (de) | 1996-04-10 | 1997-10-16 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug |
| JPH10328314A (ja) * | 1997-06-02 | 1998-12-15 | Nippon Electric Glass Co Ltd | 温熱治療用セメント材料及び温熱治療用インプラント材 |
| JPH10337335A (ja) * | 1997-06-06 | 1998-12-22 | Nippon Electric Glass Co Ltd | 温熱治療用インプラント材 |
| DE19726282A1 (de) | 1997-06-20 | 1998-12-24 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| US6267782B1 (en) * | 1997-11-20 | 2001-07-31 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
| CA2379357C (en) * | 1999-07-16 | 2011-03-22 | Wm. Marsh Rice University | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
| DE10059151C2 (de) | 2000-11-29 | 2003-10-16 | Christoph Alexiou | Magnetische Partikel zur zielgerichteten regionalen Therapie und Verwendung derselben |
| US6527693B2 (en) * | 2001-01-30 | 2003-03-04 | Implant Sciences Corporation | Methods and implants for providing radiation to a patient |
| EP1496860A1 (en) | 2001-09-28 | 2005-01-19 | Saoirse Corporation | Localized non-invasive biological modulation system |
| DE10164309A1 (de) * | 2001-12-28 | 2003-07-10 | Fraunhofer Ges Forschung | Verbesserte strukturiert-funktionale Bindematrices für Biomoleküle |
| US7101394B2 (en) * | 2002-05-02 | 2006-09-05 | Boston Scientific Scimed, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
| AU2003301251A1 (en) * | 2002-10-15 | 2004-05-04 | Ferx Incorporated | Magnetically guided particles for radiative therapies |
| ITTO20020994A1 (it) * | 2002-11-15 | 2004-05-16 | Torino Politecnico | Materiali magnetici biocompatibili per il trattamento del cancro mediante ipertermia, e processi per la loro realizzazione. |
| DE10350248A1 (de) | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
| US20070196281A1 (en) | 2003-12-31 | 2007-08-23 | Sungho Jin | Method and articles for remote magnetically induced treatment of cancer and other diseases, and method for operating such article |
| WO2005070471A2 (en) | 2004-01-20 | 2005-08-04 | Alnis Biosciences, Inc. | Articles comprising magnetic material and bioactive agents |
| CN102783499A (zh) * | 2004-07-30 | 2012-11-21 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| US20070243255A1 (en) * | 2004-09-28 | 2007-10-18 | Bing Xu | Multifunctional supramolecular hydrogels as biomaterials |
| DE102005016873A1 (de) * | 2005-04-12 | 2006-10-19 | Magforce Nanotechnologies Ag | Nanopartikel-Wirstoff-Konjugate |
| EP1883425A1 (en) * | 2005-05-23 | 2008-02-06 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| FR2889449B1 (fr) | 2005-08-05 | 2011-06-10 | Khorionyx | Preparations implantables |
| DE102005039579B4 (de) | 2005-08-19 | 2022-06-30 | Magforce Ag | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| WO2007095454A2 (en) * | 2006-02-10 | 2007-08-23 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Carbon-encased metal nanoparticles and sponges, methods of synthesis, and methods of use |
| JP2010516705A (ja) * | 2007-01-19 | 2010-05-20 | トリトン バイオシステムズ、インク． | 温熱療法におけるサセプタとその使用法 |
-
2008
- 2008-02-11 DE DE102008008522A patent/DE102008008522A1/de not_active Withdrawn
-
2009
- 2009-02-11 US US12/864,793 patent/US20110223255A1/en not_active Abandoned
- 2009-02-11 EP EP09711314.6A patent/EP2249804B1/de active Active
- 2009-02-11 DK DK09711314.6T patent/DK2249804T3/en active
- 2009-02-11 PL PL09711314T patent/PL2249804T3/pl unknown
- 2009-02-11 MX MX2010008806A patent/MX2010008806A/es active IP Right Grant
- 2009-02-11 CA CA2712832A patent/CA2712832C/en active Active
- 2009-02-11 ES ES09711314.6T patent/ES2619509T3/es active Active
- 2009-02-11 PT PT97113146T patent/PT2249804T/pt unknown
- 2009-02-11 RU RU2010136311/15A patent/RU2524644C2/ru active
- 2009-02-11 SG SG2013010590A patent/SG188146A1/en unknown
- 2009-02-11 DE DE112009000905T patent/DE112009000905A5/de not_active Withdrawn
- 2009-02-11 BR BRPI0906611A patent/BRPI0906611A8/pt not_active IP Right Cessation
- 2009-02-11 JP JP2010546211A patent/JP5649455B2/ja active Active
- 2009-02-11 AU AU2009214533A patent/AU2009214533B2/en active Active
- 2009-02-11 KR KR1020107017850A patent/KR101581973B1/ko active Active
- 2009-02-11 CN CN2009801043533A patent/CN101938993A/zh active Pending
- 2009-02-11 WO PCT/DE2009/000196 patent/WO2009100716A2/de not_active Ceased
-
2010
- 2010-07-21 IL IL207137A patent/IL207137A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5649455B2 (ja) | ナノ粒子を含む移植可能な製品 | |
| Fu et al. | Multifunctional electrospun nanofibers for enhancing localized cancer treatment | |
| Raza et al. | Cancer nanomedicine: focus on recent developments and self-assembled peptide nanocarriers | |
| Gentile et al. | Layer-by-layer assembly for biomedical applications in the last decade | |
| JP5512968B2 (ja) | 治療物質を細胞の中へ送達するための方法 | |
| JP4684991B2 (ja) | 薬物添加ナノカプセルを用いる局所的薬物デリバリー | |
| Dodda et al. | Progress in the drug encapsulation of poly (lactic-co-glycolic acid) and folate-decorated poly (ethylene glycol)–poly (lactic-co-glycolic acid) conjugates for selective cancer treatment | |
| Hadjiargyrou et al. | Enhanced composite electrospun nanofiber scaffolds for use in drug delivery | |
| JP2015007139A5 (enExample) | ||
| CA2823355A1 (en) | Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore | |
| JP2016508486A (ja) | 経動脈的薬剤送達 | |
| Wang et al. | Trifunctional Fe3O4/CaP/Alginate core–shell–corona nanoparticles for magnetically guided, pH-responsive, and chemically targeted chemotherapy | |
| Talimi et al. | Sirolimus-exuding core-shell nanofibers as an implantable carrier for breast cancer therapy: preparation, characterization, in vitro cell studies, and in vivo anti-tumor activity | |
| Villalba-Rodriguez et al. | Bio-inspired biomaterials and their drug delivery perspectives-A review | |
| Sen et al. | Recent progress in chitosan-based nanofibers as potential drug carriers in cancer therapy | |
| Gulati et al. | In situ transformation of chitosan films into microtubular structures on the surface of nanoengineered titanium implants | |
| WO2017153973A1 (en) | Biodegradable ureteral stents, methods and uses thereof | |
| Toledo et al. | Polymer nanofibers for biomedical applications: Advances in electrospinning | |
| Rajakumari et al. | Biomaterials and Its Advances for Delivering Anticancer Drugs | |
| Ito et al. | Local administration of an anti-cancer drug using tissue adhesive microparticles based on hydrophobically modified Alaska pollock gelatin for post-surgical cancer chemotherapy | |
| 이혜리 et al. | Targeted MRI Contrast Agent Based on Hyperbranched Lipopolymer Hybrids | |
| KR102195910B1 (ko) | 종양 특이적 효소 응답형 나노섬유가 코팅된 보리노스탯 방출형 소화관 스텐트 및 그 제조방법 | |
| CN117815188A (zh) | 具有光激活效应的载药微储库以及相关产品、用途、制备的方法和喷涂的方法 | |
| 방수미 et al. | Injectable hydrogel from modified CMC as a barrier for prevention of post-operative tissue adhesion | |
| Jiang Jr | Mussel-inspired biomimetic materials for tissue-engineering scaffold and controlled drug release |