CN101932564B - 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类 - Google Patents

作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类 Download PDF

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Publication number
CN101932564B
CN101932564B CN2009801019017A CN200980101901A CN101932564B CN 101932564 B CN101932564 B CN 101932564B CN 2009801019017 A CN2009801019017 A CN 2009801019017A CN 200980101901 A CN200980101901 A CN 200980101901A CN 101932564 B CN101932564 B CN 101932564B
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compound
compounds
akt
compound according
disease
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Chinese (zh)
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CN101932564A (zh
Inventor
约瑟夫·R·本西克
詹姆斯·F·布拉克
尼古拉斯·C·卡兰
伊恩·S·米切尔
基思·L·斯潘塞
校登明
徐睿
克里斯廷·沙博
史蒂文·多
梁军
布赖恩·萨菲纳
张碧荣
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Genentech Inc
Array Biopharma Inc
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Genentech Inc
Array Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2009801019017A 2008-01-09 2009-01-09 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类 Active CN101932564B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2009208P 2008-01-09 2008-01-09
US61/020,092 2008-01-09
PCT/US2009/030610 WO2009089459A1 (en) 2008-01-09 2009-01-09 Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CN101932564A CN101932564A (zh) 2010-12-29
CN101932564B true CN101932564B (zh) 2012-12-26

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CN2009801019017A Active CN101932564B (zh) 2008-01-09 2009-01-09 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类

Country Status (18)

Country Link
US (1) US8835434B2 (enExample)
EP (1) EP2247578B1 (enExample)
JP (1) JP5346345B2 (enExample)
KR (1) KR101624753B1 (enExample)
CN (1) CN101932564B (enExample)
AU (1) AU2009204025B2 (enExample)
BR (1) BRPI0906798A2 (enExample)
CA (1) CA2711699A1 (enExample)
CR (1) CR11601A (enExample)
EC (1) ECSP10010389A (enExample)
ES (1) ES2422733T3 (enExample)
IL (1) IL206575A0 (enExample)
MA (1) MA32183B1 (enExample)
NZ (1) NZ586346A (enExample)
RU (1) RU2504542C2 (enExample)
UA (1) UA100545C2 (enExample)
WO (1) WO2009089459A1 (enExample)
ZA (1) ZA201004769B (enExample)

Families Citing this family (9)

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US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2009089352A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
US8372842B2 (en) 2008-01-09 2013-02-12 Array Biopharma Inc. Pyrazolopyridines as kinase inhibitors
ES2426092T3 (es) 2008-01-09 2013-10-21 Array Biopharma, Inc. 5H-Ciclopenta[d]pirimidinas como inhibidores de proteínas cinasas AKT
MX2014013865A (es) * 2012-05-17 2015-05-07 Genentech Inc Proceso para elaborar compuestos de ciclopentilpirimidina hidroxilada.
KR102678074B1 (ko) * 2012-05-17 2024-06-26 제넨테크, 인크. 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법
EP3068770B1 (en) 2013-11-15 2019-10-23 F.Hoffmann-La Roche Ag Processes for the preparation of pyrimidinylcyclopentane compounds

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Also Published As

Publication number Publication date
CN101932564A (zh) 2010-12-29
EP2247578A1 (en) 2010-11-10
ECSP10010389A (es) 2010-11-30
AU2009204025A1 (en) 2009-07-16
KR20100118110A (ko) 2010-11-04
US8835434B2 (en) 2014-09-16
ZA201004769B (en) 2011-12-28
JP2011509308A (ja) 2011-03-24
MA32183B1 (fr) 2011-04-01
IL206575A0 (en) 2010-12-30
UA100545C2 (ru) 2013-01-10
BRPI0906798A2 (pt) 2015-07-14
KR101624753B1 (ko) 2016-05-26
CA2711699A1 (en) 2009-07-16
US20110065716A1 (en) 2011-03-17
ES2422733T3 (es) 2013-09-13
NZ586346A (en) 2012-02-24
WO2009089459A1 (en) 2009-07-16
JP5346345B2 (ja) 2013-11-20
EP2247578B1 (en) 2013-05-22
RU2504542C2 (ru) 2014-01-20
RU2010132911A (ru) 2012-02-20
CR11601A (es) 2010-08-19
AU2009204025B2 (en) 2014-02-20

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