CN101925383A - 甲酰胺化合物及其作为趋化因子受体激动剂的应用 - Google Patents

甲酰胺化合物及其作为趋化因子受体激动剂的应用 Download PDF

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Publication number
CN101925383A
CN101925383A CN2008801255852A CN200880125585A CN101925383A CN 101925383 A CN101925383 A CN 101925383A CN 2008801255852 A CN2008801255852 A CN 2008801255852A CN 200880125585 A CN200880125585 A CN 200880125585A CN 101925383 A CN101925383 A CN 101925383A
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trifluoromethyl
alkyl
pyrrolidin
methyl
carbonyl
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Chinese (zh)
Inventor
E·本-泽夫
陈东立
M·菲克曼
S·高希
S·克尔纳
J·林
Y·马兰茨
R·梅林德兹
P·莫汉蒂
S·沙哈姆
Z·张
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Epix Delaware Inc
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Epix Delaware Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
CN2008801255852A 2007-12-11 2008-12-11 甲酰胺化合物及其作为趋化因子受体激动剂的应用 Pending CN101925383A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1281907P 2007-12-11 2007-12-11
US61/012,819 2007-12-11
US3667508P 2008-03-14 2008-03-14
US61/036,675 2008-03-14
PCT/US2008/086388 WO2009076512A1 (en) 2007-12-11 2008-12-11 Carboxamidξ compounds and their use as chemokine receptor agonists

Publications (1)

Publication Number Publication Date
CN101925383A true CN101925383A (zh) 2010-12-22

Family

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CN2008801255852A Pending CN101925383A (zh) 2007-12-11 2008-12-11 甲酰胺化合物及其作为趋化因子受体激动剂的应用

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Country Link
US (1) US8569282B2 (enExample)
EP (1) EP2280766A1 (enExample)
JP (1) JP2011506466A (enExample)
KR (1) KR20100102646A (enExample)
CN (1) CN101925383A (enExample)
AU (1) AU2008335135A1 (enExample)
BR (1) BRPI0820701A2 (enExample)
CA (1) CA2708364A1 (enExample)
RU (1) RU2010128543A (enExample)
WO (1) WO2009076512A1 (enExample)

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CN104507939A (zh) * 2012-05-31 2015-04-08 卫材R&D管理有限公司 四氢吡唑并嘧啶化合物
WO2025055965A1 (zh) * 2023-09-13 2025-03-20 中国药科大学 氮杂环丁烷衍生物、其制备方法及其医药用途
WO2025131049A1 (en) * 2023-12-21 2025-06-26 Ignis Therapeutics (Suzhou) Limited Dihydro-pyrrolo-pyridine derivatives and uses thereof

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CN102459225B (zh) * 2009-04-16 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂
CN102459226B (zh) * 2009-04-17 2014-09-17 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂
EP2419419B1 (en) * 2009-04-17 2014-12-03 Janssen Pharmaceutica NV 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
CN103717594B (zh) 2011-06-22 2016-12-14 普渡制药公司 包含二羟基取代基的trpv1拮抗剂及其用途
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WO2023056039A1 (en) * 2021-10-01 2023-04-06 Xinthera, Inc. Azetidine and pyrrolidine parp1 inhibitors and uses thereof
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EP2280766A1 (en) 2011-02-09
JP2011506466A (ja) 2011-03-03
AU2008335135A1 (en) 2009-06-18
KR20100102646A (ko) 2010-09-24
BRPI0820701A2 (pt) 2015-06-16
CA2708364A1 (en) 2009-06-18

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