CN101912325A - 一种输送粘性材料的注射器 - Google Patents

一种输送粘性材料的注射器 Download PDF

Info

Publication number
CN101912325A
CN101912325A CN2010102727775A CN201010272777A CN101912325A CN 101912325 A CN101912325 A CN 101912325A CN 2010102727775 A CN2010102727775 A CN 2010102727775A CN 201010272777 A CN201010272777 A CN 201010272777A CN 101912325 A CN101912325 A CN 101912325A
Authority
CN
China
Prior art keywords
syringe
hole
positive displacement
plunger
displacement mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010102727775A
Other languages
English (en)
Inventor
J·R·麦肯兹
S·R·康斯顿
D·J·库皮基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iscience Surgical Corp
Original Assignee
Iscience Surgical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iscience Surgical Corp filed Critical Iscience Surgical Corp
Publication of CN101912325A publication Critical patent/CN101912325A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/486—Indicating injection pressure

Abstract

提出了一种注射器，可输送微量粘性材料到体内，如眼睛，用于外科手术。注射器包括注射器主体，带有设置其中的柱塞，柱塞连接到强制性位移机构，其能够逐步推动柱塞，以恒定或预先确定的输送速率，精确地输送微量材料。

Description

一种输送粘性材料的注射器
相关申请
依照美国法典35USC 119(e)和363，要求享有2004年1月12日提出申请的美国临时专利申请No.60/536,080的优先权。该申请所公开的内容在本文结合引用。
技术领域
本发明涉及一种改进的输送高粘性材料通过套管或针头进入组织的装置。
背景技术
眼科手术中，通常称作手术粘弹性介质的高粘性材料作为手术辅助剂注入到眼中。用于眼科手术的粘弹性材料包括含有透明质酸，软骨素硫酸盐或化学改性纤维素的组分。由于这些材料具有特殊的剪切稀化或搅溶性能，粘弹性材料可通过小孔针头或套管注入，然后在注入后回弹成为提供韧性凝胶性能的材料。粘弹性材料通常在白内障手术时注入眼睛的前房，以保持眼内的空间，保护角膜内皮免受机械损伤。进行青光眼手术时注射粘弹性材料用于扩大组织空间，如Schlemm`s管。注入粘弹性材料还可用于分开组织，如晶状体囊或视网膜。
粘弹性材料一般通过手术人员手动控制注射器输送到组织中。手动操作的注射器注射粘弹性材料是通过连接到注射器远端Luer固定件的针头或套管。由于材料的高粘度，通常难以手动对注射器产生足够的力，尤其是对小孔套管或针头。此外，粘弹性材料的动态流动特性使其难以通过精确和可控的方式输送少量材料。
发明内容
本发明提供了一种输送粘性材料的注射器，包括注射器主体，设有远端和近端，连接两个端部的通孔，远端带有流体出口。柱塞设置在通孔内，连接到强制性位移机构，其能够逐步地朝远端推动柱塞，将容纳于通孔中的流体材料通过流体出口压出。
强制性位移机构可包括螺杆，连接到柱塞或具有一系列机械止动件的线性移动机构。
强制性位移机构可连接到移动动力源，提供平稳和恒定的力来驱动柱塞。
附图说明
图1是根据本发明的第一实施例的注射器的示意性截面图；
图2是根据本发明的第二实施例的注射器的示意性截面图；
图3是根据本发明的第三实施例的注射器的示意性截面图；
图4是根据本发明的第四实施例的注射器的示意性截面图，注射器设置了压力表，可测量和调节注射器出口的压力；
图5是示例5介绍的注射器输送的粘弹性材料的压力相对流速的图表。
具体实施方式
本发明的注射器包括注射器主体，具有近端和相对的远端，两端之间设有通孔。柱塞设置在通孔内，并连接到受到促动可提供柱塞强制性位移的机构。强制性位移机构允许高度精确地从远端输送注射器主体内的粘性，尤其是粘弹性材料。“强制性位移”是指施加到柱塞和/或柱塞的线性移动机构的力受到递增限制，可从注射器主体的远端提供恒定的或增量的和精确和可控的材料输送。强制性位移机构设置成允许柱塞以不连续的增量方式逐步线性移动以控制输送。注射器主体具有位于远端的流体出口，其端接到固定件，如连接针头或套管的Luer固定件。
参考图1，在注射器3的一个实施例中，螺杆1的远端连接到柱塞6。柱塞6位于注射器主体4内，设有近端凸缘8。盖帽5连接到凸缘8。螺杆1的近端是手柄2，可用作指轮来转动螺杆，推动柱塞6。止动件7位于注射器主体4内，当相对注射器主体内的粘性材料施加推动柱塞的力时，形成气密密封。粘性材料通过注射器远端压出进入适当的接收机构。
参考图2，在注射器10的另一实施例中，筒体12预先充满粘弹性材料并包括位于远端的橡胶隔膜22。筒体可装入注射器主体11，然后通过可控的方式使用螺旋机构注射，螺旋机构包括螺杆18，其连接到远端的柱塞组件16，柱塞组件包括柱塞19，止推衬套20和橡胶止动件23，可在注射器主体11内滑动移动。注射器10包括盖帽组件15和注射器主体11。柱塞19设有密封件，如O型圈或橡胶凸缘(未显示)，帮助柱塞19和注射器主体11之间形成流体密封。螺杆18延伸通过位于注射器主体11近端的盖帽组件15的相配合的螺纹孔。转动杆18的端部可推动柱塞19压出筒体12内的粘性材料。盖帽15可取下，以便插入预先充填的筒体12到注射器主体11的通孔中。注射器主体在注射器的远端结合有内针头13，以便刺入筒体。针头提供了从筒体到位于注射器远端的突出Luer固定件14的流体路径。橡胶隔膜22提供了筒体与内针头的流体密封。位于柱塞组件16端部的内部止推衬套20和橡胶止动件23与筒体12的近端表面接触。注射器手柄21转动时，螺杆18作用于柱塞组件16，提供强制性位移作用于筒体，输送筒体的容纳物通过远端的Luer固定件14。
由于没有可压缩的元件，使用强制性位移机构保证了精确和可重复的输送特性。根据本发明的注射器可精确地输送小增量(微量)的粘性流体，一般范围在5到25微升。因为试图通过小孔针头，微套管或微导管输送少量粘性流体是很困难的，本发明的优势也在于此。在手术中精确的输送少量粘性流体非常关键，流体用于扩大或分开微小的组织结构。
参考图3，在另一实施例中，强制性位移机构包括螺杆40，其连接注射器主体板41到平行的柱塞板44。转动杆40可相向或相对移动板41，44。板41连接到注射器主体42，板44连接到柱塞轴43，柱塞的移动使得可精确控制从注射器主体输送的材料。
在另一实施例中，强制性位移机构包括柱塞，其设有一系列的间隔开的机械止动件，具有预先确定的间隔，设置成允许柱塞线性前进，从一个机械止动件到下一个机械止动件。释放机构或另外的推动力可用来继续推动柱塞移动到下一个止动件。各止动件允许的柱塞移动量应适当，以进行精确的注射器输送。
在另一实施例中，强制性位移机构连接到传统的注射器主体，允许注射器用于各种预先包装的粘弹性注射器套件。例如，该机构可连接到注射器凸缘，作用于或位移提供的柱塞。
因此，注射器还有的特征是可包括于套件，该套件包括注射器，一个或多个微套管，用于从注射器输送材料到手术位置；和/或预先包装的含有粘弹性材料的筒体，粘弹性材料用于手术或医学应用。
注射器可用任何适当的高强度材料如金属和聚合物制造。优选采用通过传统的方式，如高压浸出，环氧乙烷气体处理或暴露于致电离辐射，进行灭菌的材料。适当的材料包括金属，如钢和钛，聚合物，如聚砜，聚乙烯，尼龙，聚甲基丙烯酸甲酯，聚对苯二甲酸乙二醇酯，聚丙烯和聚碳酸酯。
注射器还可用于可控速度地输送，通过保持预先确定的可变或恒定的注射压力，以缓慢和预先确定的流速精确地输送粘性流体。当通过小孔机构，如微套管或微导管以可控注射压力注射时，形成恒定的或预先确定流量的粘性流体。调节在注射器出口或注射器内测出的注射压力使得流动速度可控制。参考图4，压力调节可通过连接压力表36或变送器到注射器35来实现。恒定的注射压力可通过手动控制强制性位移机构同时监控注射压力来保持，或者通过电反馈到电动促动器来驱动注射机构。在一可选实施例中，压力调节可通过机械机构和通过限制强制性位移机构施加的力来实现。例如，离合器机构可结合到螺纹驱动机构，来限制施加的输送粘性材料的最大力。
注射器还可结合减压阀，防止粘性流体输送时产生过压力或压力峰。减压阀可包括球和弹簧组件，其中球由弹簧力压在小孔上，直到注射压力克服弹簧力，允许流体流过和释放压力。减压阀可设计成允许使用者调节最大注射压力。
为了说明提供下面的示例，示例不能用来以任何方式限制本发明的范围。
示例1
注射器包括用聚碳酸酯制造的注射器主体，设计可容纳预先充满粘弹性材料的筒体。在其远端，尖锐的量针22结合到注射器主体的小轴向通孔。与量针同心的沉孔可接收突出的luer固定件。针的尖锐近端突出到注射器的孔中，以便刺穿放置到注射器主体内的筒体的橡胶隔膜。在注射器近端，注射器主体设有外螺纹，以配合盖帽和柱塞组件。盖帽组件包括具有内螺纹(1/2-13UNC)的聚碳酸酯盖帽，其中心设有小螺纹孔(5-40UNC)，不锈钢螺纹杆位于螺纹孔中。螺纹杆的远端连接有聚碳酸酯柱塞，其表面固定有低摩擦的乙酰止推衬套。带突起的指轮连接到螺纹杆的近端。由制造商(如Advanced Medical Optics Inc.)提供的粘弹性材料筒体用橡胶隔膜密封于远端和孔内的橡胶止动件。将筒体放置到注射器的孔中后，刺穿隔膜，盖帽组件螺旋连接到注射器，螺纹的柱塞端进插入筒体孔。螺纹前进直到止推衬套接触橡胶止动件。螺纹继续前进使得粘弹性材料从注射器主体通过针头和Luer固定件压出。乙酰止推衬套可防止旋转的螺纹施加扭矩到止动件，帮助保持止动件密封于筒体孔。根据螺纹的螺距(每英寸40螺纹)和筒体的孔(6.72mm)，可从注射器压出精确数量的粘弹性材料。
螺纹：1转＝1/40英寸＝0.025英寸＝0.635毫米
筒体孔面积：π×(6.72)2/4＝35.4平方毫米
体积/转：0.635×35.4＝22.5立方毫米
示例2
注射器包括螺纹驱动的注射器柱塞，设计成可接收传统的注射器主体。该装置包括盖帽部分，其上设有槽，可插入注射器凸缘；推动柱塞的进给螺纹，和指轮，用于转动进给螺纹。准备使用时进给螺纹缩回到最近位置。注射器的凸缘然后插入盖帽的槽中。注射器孔与盖帽的轴线对齐。然后推动螺纹进入注射器孔，直到柱塞接触注射器的止动件。继续推进螺纹使得粘弹性材料从注射器主体通过针头和Luer固定件压出。
示例3
对示例1的注射器测试了输送3种手术粘弹性材料，Healon，Healon GV和Healon 5(Advanced Medical Optics Inc.生产)，分别具有对应的零剪切粘度300,000mPas，3,000,000mPas和7,000,000mPas。注射器的螺旋机构转1/4，1/2和1圈输送各粘弹性材料。产生的输送材料放到配衡的称重舟皿，在分析天平(Mettler AG285)进行称重。结果在下面的表一给出。响应螺纹机构的转动从注射器压出的输送粘弹性材料证明了线性输送特性。因为粘弹性材料都具有接近1mg/mm3的粘度，输送的材料重量还证明与计算出的输送体积有很好的对应。
表一
Figure BSA00000257370300061
Figure BSA00000257370300071
示例4
为了保证恒定流量输送手术粘弹性材料通过90微米直径内腔的眼科微套管(美国，加利福尼亚，Redwood City的Science Surgical Corporation生产)，示例1的注射器连接到串联有压力表的微套管。输送粘弹性材料(Healon GV，由Advanced Medical Optics Inc.提供)以充填系统。旋紧注射器螺纹以得到误差为±5％的300psi的输送压力，并保持该范围60秒。在此期间从微套管端部压出的全部流体用盘子收集并进行称重。5次实验得到的数据进行平均，计算出标准偏差。表二显示了得到的结果。
表二
Figure BSA00000257370300072
注射器输送了恒定流量的粘弹性材料，每分钟大约为5.4毫克，对应于每分钟大约5.4微升。
示例5
为了证明控制恒定流量输送的能力，测量了手术粘弹性材料(Healon GV，由Advanced Medical Optics Inc.提供)在100和400psi之间的多个固定压力下通过90微米直径内腔的眼科微套管(Science Surgical Corporation生产)的流量。每个压力下至少测试三个样品三次。一共测试了9个压力水平(100，150，175，200，225，250，300，350和400psi)。通过将示例1的强制性位移注射器串联连接校准的压力表，然后连接到微套管，推动注射器的进给螺纹直到粘弹性材料充填微套管并从远端压出，进行各样品的测试。螺纹前进的速率然后手动调节，保持输送压力于目标水平。目标压力水平保持最少3分钟，用小杯接收粘弹性流体。在三分钟结束时，压出的粘弹性流体进行称重，计算流量。参考图5，图表上的数据显示出各压力下的平均值。

Claims (27)

1.一种输送粘性材料的注射器，包括：
注射器主体，设有近端，带有出口的远端，和两端之间的通孔；和
设置在通孔中的柱塞，连接到强制性位移机构，其能够逐步朝注射器主体的远端推动柱塞，将通孔中的材料通过所述出口压出，其中所述强制性位移机构包括一系列间隔开的机械止动件，用于控制所述柱塞的线性位移；
适于容纳在所述通孔之间的可移动的筒体，所述筒体包含所述粘性材料；
位于所述通孔的远端的内针头，以刺入所述筒体。
2.根据权利要求1所述的注射器，其特征在于，所述强制性位移机构包括连接到所述柱塞的螺杆。
3.根据权利要求2所述的注射器，其特征在于，所述螺杆的螺距大于或等于每英寸40个螺纹。
4.根据权利要求1所述的注射器，其特征在于，所述强制性位移机构包括一系列间隔开的机械止动件，用于控制所述柱塞的线性位移。
5.根据权利要求1所述的注射器，其特征在于，所述强制性位移机构连接到移动动力源。
6.根据权利要求1所述的注射器，其特征在于，所述强制性位移机构提供可重复的小于约25微升的材料输送体积增量。
7.根据权利要求1所述的注射器，其特征在于，还包括调节注射压力的调节器的机构，所述调节器包括衰减器以限制所施加的用来压出所述材料的力。
8.根据权利要求1所述的注射器，其特征在于，还包括注射器压力监测机构。
9.根据权利要求8所述的注射器，其特征在于，所述监测机构向促动器提供压力反馈信息，所述促动器提供能量驱动所述强制性位移机构。
10.根据权利要求7所述的注射器，其特征在于，所述调节注射压力的机构包括衰减器，以限制压出所述材料所施加的力。
11.根据权利要求10所述的注射器，其特征在于，所述衰减器包括离合器，可接合到所述强制性位移机构。
12.根据权利要求1所述的注射器，其特征在于，还包括减压阀，以释放所述通孔中的压力。
13.一种输送微量粘性材料的装置，包括：
输送粘性材料的注射器，包括注射器主体，设有近端，带有出口的远端，和两端之间的通孔；和设置在通孔中的柱塞，其连接到强制性位移机构，能够逐步朝注射器主体的远端推动柱塞，将通孔中的材料从所述出口压出；和
与所述出口连通的微导管；
适于容纳在所述通孔之间的可移动的筒体，所述筒体包含所述粘性材料；
位于所述通孔的远端的内针头，以刺入所述筒体。
14.根据权利要求13所述的装置，其特征在于，所述微量在约5到25微升的范围内。
15.根据权利要求13所述的装置，其特征在于，所述注射器的所述强制性位移机构包括连接到所述柱塞的螺杆。
16.根据权利要求15所述的装置，其特征在于，所述螺杆的螺距大于或等于每英寸40个螺纹。
17.权利要求13所述的装置，其特征在于，所述注射器的所述强制性位移机构包括带有一系列间隔开的机械止动件的线性移动机构。
18.根据权利要求13所述的装置，其特征在于，所述注射器的所述强制性位移机构连接到移动动力源。
19.根据权利要求13所述的装置，其特征在于，所述注射器的所述强制性位移机构提供可重复的小于约25微升的材料输送体积增量。
20.根据权利要求13所述的装置，其特征在于，所述注射器还包括调节注射压力的机构。
21.根据权利要求13所述的装置，其特征在于，所述注射器还包括注射器压力监测机构。
22.根据权利要求21所述的装置，其特征在于，所述监测机构向促动器提供压力反馈信息，所述促动器提供动力驱动所述强制性位移机构。
23.根据权利要求20所述的装置，其特征在于，所述调节注射压力的机构包括衰减器，可限制压出所述材料所施加的力。
24.根据权利要求23所述的装置，其特征在于，所述衰减器包括离合器，可接合所述强制性位移机构。
25.根据权利要求13所述的装置，其特征在于，所述注射器还包括减压阀，以释放所述通孔中的压力。
26.一种输送微量粘性材料的成套件，包括：
粘性材料注射器，包括注射器主体，设有近端，带有出口的远端，和两端之间的通孔；和设置在通孔中的柱塞，其连接到强制性位移机构，能够逐步朝注射器主体的远端推动柱塞，将通孔中的材料通过所述出口压出；和
微导管；
位于所述通孔的远端的内针头，以刺入包含所述粘性材料的适于容纳在所述通孔之间的筒体；
预先包装好的筒体，适合置于所述注射器内，所述筒体容纳有粘性材料。
27.一种输送微量粘性材料的成套件，包括：
用于粘性材料的注射器，包括注射器主体，设有近端，带有出口的远端，和两端之间的通孔；和设置在通孔中的柱塞，其连接到强制性位移机构，能够逐步朝注射器主体的远端推动柱塞，将通孔中的材料通过所述出口压出；
位于所述通孔的远端的内针头，以刺入包含所述粘性材料的适于容纳在所述通孔之间的筒体；和
预先包装好的筒体，适合置于所述注射器内，所述筒体容纳有所述粘性材料。
CN2010102727775A 2004-01-12 2005-01-12 一种输送粘性材料的注射器 Pending CN101912325A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53608004P 2004-01-12 2004-01-12
US60/536080 2004-01-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2005800072920A Division CN1950124B (zh) 2004-01-12 2005-01-12 一种输送粘性材料的注射器

Publications (1)

Publication Number Publication Date
CN101912325A true CN101912325A (zh) 2010-12-15

Family

ID=34806984

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010102727775A Pending CN101912325A (zh) 2004-01-12 2005-01-12 一种输送粘性材料的注射器
CN2005800072920A Active CN1950124B (zh) 2004-01-12 2005-01-12 一种输送粘性材料的注射器

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2005800072920A Active CN1950124B (zh) 2004-01-12 2005-01-12 一种输送粘性材料的注射器

Country Status (9)

Country Link
US (1) US7967772B2 (zh)
EP (1) EP1706172A4 (zh)
JP (2) JP2007520276A (zh)
KR (1) KR20060130648A (zh)
CN (2) CN101912325A (zh)
AU (1) AU2005206872B2 (zh)
BR (1) BRPI0506837A (zh)
CA (1) CA2552966C (zh)
WO (1) WO2005069831A2 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109939890A (zh) * 2018-12-04 2019-06-28 深圳市东信硅材料有限公司 一种点胶设备的压料装置
CN111249062A (zh) * 2012-07-03 2020-06-09 诺华股份有限公司 注射器
CN112312868A (zh) * 2018-04-12 2021-02-02 新世界医学有限公司 用于眼内流体注射的装置和方法

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
JP4264704B2 (ja) 2001-04-07 2009-05-20 グローコス コーポレーション 緑内障ステントおよび緑内障治療方法
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
EP1476210B1 (en) 2002-02-11 2008-09-24 Antares Pharma, Inc. Intradermal injector
EP3572106A1 (en) 2003-04-23 2019-11-27 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
BRPI0506837A (pt) 2004-01-12 2007-06-12 Iscience Surgical Corp injetor para materiais viscosos, e, dispositivos e kit para fornecer microquantidades de materiais viscosos
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
JP5216328B2 (ja) 2005-01-24 2013-06-19 アンタレス ファーマ インコーポレイテッド あらかじめ充填された針補助シリンジジェット式注射器
ES2377000T3 (es) * 2005-09-07 2012-03-21 Thomas Steffen Dispositivo para la inyección de material de alta viscosidad
US20070202186A1 (en) * 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
CA2646324C (en) 2006-03-30 2016-06-07 Valeritas, Llc Multi-cartridge fluid delivery device
US7563256B2 (en) * 2006-03-30 2009-07-21 Isaac Hearne Cannula tip eye drop dispenser
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
JP5011812B2 (ja) * 2006-05-12 2012-08-29 富士通株式会社 細胞内への液体吐出方法及びマイクロインジェクション装置
US7909789B2 (en) 2006-06-26 2011-03-22 Sight Sciences, Inc. Intraocular implants and methods and kits therefor
US20090124996A1 (en) * 2006-11-03 2009-05-14 Scott Heneveld Apparatus and methods for injecting high viscosity dermal fillers
US8506515B2 (en) 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US8038649B2 (en) * 2007-09-18 2011-10-18 Shl Group Ab Automatic injection device with needle insertion
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
CA2705239C (en) 2007-11-08 2018-09-25 Alimera Sciences, Inc. Ocular implantation device
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8512404B2 (en) 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
EP2231258A1 (en) 2007-12-21 2010-09-29 Aesthetic Sciences Corporation Self-contained pressurized injection device
EP2259833A1 (en) 2008-03-05 2010-12-15 Ivantis, INC. Methods and apparatus for treating glaucoma
EP3636301A1 (en) 2008-03-10 2020-04-15 Antares Pharma, Inc. Injector safety device
WO2009120960A2 (en) * 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
JP5611208B2 (ja) 2008-08-05 2014-10-22 アンタレス・ファーマ・インコーポレーテッド 多数回服用量の注射装置
WO2010065970A1 (en) 2008-12-05 2010-06-10 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
WO2010108116A1 (en) 2009-03-20 2010-09-23 Antares Pharma, Inc. Hazardous agent injection system
CN102395393A (zh) * 2009-04-03 2012-03-28 Ebi有限责任公司 用于传送骨水泥的方法和设备
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2011006078A1 (en) 2009-07-09 2011-01-13 Ivantis, Inc. Single operator device for delivering an ocular implant
CA2766192C (en) 2009-07-09 2017-10-24 Ivantis, Inc. Ocular implants for residing partially in schlemm's canal
CA2778452A1 (en) 2009-10-23 2011-04-28 Ivantis, Inc. Ocular implant system and method
WO2011097408A1 (en) 2010-02-05 2011-08-11 Sight Sciences, Inc Intraocular implants and related kits and methods
JP2013520233A (ja) * 2010-02-19 2013-06-06 クック メディカル テクノロジーズ エルエルシー 内視鏡的粘膜下層剥離術のための装置及び方法
CA2736841C (en) 2010-04-15 2014-02-18 Teneo Innovations Inc. Device and electronic controller for syringe piston control
US8545430B2 (en) 2010-06-09 2013-10-01 Transcend Medical, Inc. Expandable ocular devices
WO2011163505A1 (en) 2010-06-23 2011-12-29 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
JP5996544B2 (ja) 2010-10-15 2016-09-21 クリアサイド・バイオメディカル・インコーポレーテッドＣｌｅａｒｓｉｄｅ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ 眼球アクセス用装置
JP6475410B2 (ja) * 2010-11-24 2019-02-27 リーベル−フラーシャイム カンパニー エルエルシー 医療流体注入器システム
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US8672883B2 (en) 2011-07-11 2014-03-18 C. Garyen Denning Fluid delivery device and methods
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
WO2013040310A1 (en) * 2011-09-15 2013-03-21 Dewoolfson Bruce H Device and method for the controlled delivery of ophthalmic solution to the stroma of an eye
US10328211B2 (en) 2011-12-08 2019-06-25 Unl Holdings Llc Automatic self-dispensing accurate dose drug delivery syringes
DK2788054T3 (en) 2011-12-08 2018-08-06 Unl Holdings Llc ACCURATE DOSAGE CONTROL MECHANISMS AND SPRAYS FOR ADMINISTRATION OF MEDICINE
US10213556B2 (en) 2011-12-08 2019-02-26 Unl Holdings Llc Accurate dose control mechanisms and drug delivery syringes
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
PT2822618T (pt) 2012-03-06 2024-03-04 Antares Pharma Inc Seringa pré-cheia com característica de força de rutura
WO2013141898A1 (en) 2012-03-20 2013-09-26 Sight Sciences, Inc. Ocular delivery systems and methods
US9554940B2 (en) 2012-03-26 2017-01-31 Glaukos Corporation System and method for delivering multiple ocular implants
KR20150011346A (ko) 2012-04-06 2015-01-30 안타레스 팔마, 인코퍼레이티드 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
BR112015010566A2 (pt) 2012-11-08 2017-07-11 Clearside Biomedical Inc métodos e dispositivos para o tratamento de doenças oculares em indivíduos humanos
WO2014085450A1 (en) 2012-11-28 2014-06-05 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
EP4349383A2 (en) 2013-02-11 2024-04-10 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
EP2968792B1 (en) 2013-03-11 2019-05-15 Antares Pharma, Inc. Dosage injector with pinion system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
BR112015027762A2 (pt) 2013-05-03 2017-08-29 Clearside Biomedical Inc Aparelho e métodos para injeção ocular
EP3003454B1 (en) 2013-06-03 2020-01-08 Clearside Biomedical, Inc. Apparatus for drug delivery using multiple reservoirs
US10010447B2 (en) 2013-12-18 2018-07-03 Novartis Ag Systems and methods for subretinal delivery of therapeutic agents
US9205181B2 (en) 2014-01-09 2015-12-08 Rainbow Medical, Ltd. Injectable hydrogel implant for treating glaucoma
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
EP3139977B1 (en) 2014-05-07 2021-02-17 Amgen Inc. Autoinjector with shock reducing elements
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2015196085A2 (en) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
EP3229870A2 (en) 2014-12-08 2017-10-18 F. Hoffmann-La Roche AG Versatile syringe platform
US10299958B2 (en) 2015-03-31 2019-05-28 Sight Sciences, Inc. Ocular delivery systems and methods
AU2016307951B2 (en) 2015-08-14 2021-04-01 Alcon Inc. Ocular implant with pressure sensor and delivery system
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017106517A1 (en) 2015-12-15 2017-06-22 Ivantis, Inc. Ocular implant and delivery system
US10390901B2 (en) 2016-02-10 2019-08-27 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
EP3442479A1 (en) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
CA3062845A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
CN106000766B (zh) * 2016-07-07 2018-11-06 陈丹红 一种胶水注射头
CN106000765A (zh) * 2016-07-07 2016-10-12 苏州骏发精密机械有限公司 一种胶水注射装置
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
DE102016125207A1 (de) * 2016-12-21 2018-06-21 Atlas Copco Ias Gmbh Vorrichtung zum Fördern von viskosem Material
US11452798B2 (en) 2017-09-27 2022-09-27 Cook Medical Technologies Llc Crosslinking submucosal injectate system
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
WO2019070385A2 (en) 2017-10-06 2019-04-11 Glaukos Corporation SYSTEMS AND METHODS FOR PLACING MULTIPLE OCULAR IMPLANTS
US10987247B2 (en) 2017-10-18 2021-04-27 Jesus Moreno Opthalmic microsurgical instrument
US11576816B2 (en) 2017-10-18 2023-02-14 Jesus Moreno Opthalmic microsurgical instrument
USD846738S1 (en) 2017-10-27 2019-04-23 Glaukos Corporation Implant delivery apparatus
WO2019189215A1 (ja) 2018-03-28 2019-10-03 テルモ株式会社 シリンジ用ガスケット押圧具または薬液吐出具、およびそれを備えた薬液投与具
US11259961B2 (en) 2019-07-22 2022-03-01 Iantrek, Inc. Methods and devices for increasing aqueous drainage of the eye
US11504270B1 (en) 2019-09-27 2022-11-22 Sight Sciences, Inc. Ocular delivery systems and methods
CN113304353B (zh) * 2020-08-18 2023-01-10 深圳市立心科学有限公司 具有螺旋剪切机构的注射器
AU2022205382A1 (en) 2021-01-11 2023-06-22 Alcon Inc. Systems and methods for viscoelastic delivery
US11779490B1 (en) * 2022-10-11 2023-10-10 Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University Minimally invasive ab interno triple surgery for open-angle glaucoma

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3537453A (en) 1968-03-14 1970-11-03 Drummond Instr Co Microliter syringe having disposable parts
US3791560A (en) 1968-09-26 1974-02-12 Precision Sampling Corp Seals (psc-14)
GB1290230A (zh) 1970-03-20 1972-09-20
AU479960B2 (en) 1972-09-22 1977-01-11 Scientific Glass Engineering Proprietary Limited Improvements relating to syringes
US3915651A (en) * 1972-09-22 1975-10-28 Us Government Direct digital control pipette
JPS5314227Y2 (zh) 1973-03-29 1978-04-15
GB2033896B (en) * 1978-10-12 1982-11-24 Ono Pharmaceutical Co Lithiumaluminium hydride compounds
US4384581A (en) 1980-01-17 1983-05-24 Becton, Dickinson And Company Microsyringe
JPS56109741U (zh) 1980-01-24 1981-08-25
US4439185A (en) * 1981-10-21 1984-03-27 Advanced Cardiovascular Systems, Inc. Inflating and deflating device for vascular dilating catheter assembly
US4416291A (en) 1981-07-20 1983-11-22 Becton Dickinson And Company Multiple sample needle assembly with vein entry indicator
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4710178A (en) * 1982-11-03 1987-12-01 Micro-Mega S.A. Precision injection system and method for intraligmental anesthesia
US4641766A (en) * 1984-11-02 1987-02-10 Alcon Laboratories, Inc. Metering dispenser for high viscosity compositions
DE3670768D1 (de) 1985-11-08 1990-06-07 Disetronic Ag Injektionsgeraet.
FR2600258A1 (fr) * 1986-06-18 1987-12-24 Hazon Bernard Dispositif pousse-seringue pour injections parenterales automatiques a asservissement et programmation
EP0285679A1 (de) * 1987-04-04 1988-10-12 B. Braun-SSC AG Druckinfusionsapparat
US4941308A (en) * 1988-07-25 1990-07-17 Abbott Laboratories Method of packaging for a sterilizable calibratable medical device
US5135488A (en) * 1989-03-17 1992-08-04 Merit Medical Systems, Inc. System and method for monitoring, displaying and recording balloon catheter inflation data
US5015233A (en) * 1989-04-17 1991-05-14 Freedom Machine, Inc. Pneumatic inflation device
US5019048A (en) 1990-01-10 1991-05-28 Margolin George D Unit dose syringe with rotatable needle
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
SE9103215D0 (sv) 1991-11-04 1991-11-04 Kabi Pharmacia Ab A method and device for dosing a liquid preparation
ES2055648B1 (es) 1991-11-12 1995-03-01 Ramos Juan Jose Sanchez Autoinyector automatico para la administracion de medicamentos envasados en jeringas prellenadas.
US5370630A (en) * 1993-11-12 1994-12-06 Smidebush; Michael J. Device for injection of fluidic materials into body tissue
JP3458006B2 (ja) * 1994-08-02 2003-10-20 昭文 山中 高粘性液体注射装置
SE510420C2 (sv) * 1994-11-14 1999-05-25 Cma Microdialysis Ab Infusions- och mikrodialyspump
US5647853A (en) * 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
KR0138353Y1 (ko) 1996-12-13 1999-04-01 주식회사부윤테크 일회용 주사기
US6102895A (en) 1997-09-30 2000-08-15 Cortella; Julian M. Digital fluid delivery and aspiration apparatus with mechanical de-amplifier
US5925834A (en) 1997-12-16 1999-07-20 Waters Investments Limited Autosampler syringe with compression sealing
US6063057A (en) * 1998-06-01 2000-05-16 Medtronic Ave, Inc. Syringe apparatus adapted for use in catheterization procedures
US6371963B1 (en) 1998-11-17 2002-04-16 Scimed Life Systems, Inc. Device for controlled endoscopic penetration of injection needle
US6959615B2 (en) 1999-03-05 2005-11-01 Gamble Kimberly R Sample collection and processing device
US6645167B1 (en) * 1999-05-21 2003-11-11 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an embolizing composition
US7018365B2 (en) * 1999-05-21 2006-03-28 Micro Therapeutics, Inc. Threaded syringe with quick stop
US6520928B1 (en) 1999-08-19 2003-02-18 Alceu Meibach Rosa Junior Medical liquid injection system and method
JP4489886B2 (ja) * 1999-12-28 2010-06-23 株式会社吉田製作所 歯科用自動注射器
SE0001893D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab Medical arrangement
US6565535B2 (en) * 2000-06-16 2003-05-20 Nardo Zaias Medical infusion and aspiration system
AU2001271440A1 (en) * 2000-06-27 2002-01-08 Kyphon Inc. Systems and methods for injecting flowable materials into bones
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US6712794B2 (en) * 2001-08-21 2004-03-30 Spinal Specialties, Inc. Apparatus for delivering a viscous liquid to a surgical site
KR100976186B1 (ko) 2001-11-21 2010-08-17 아이싸이언스 코포레이션 안과 정밀 수술 시스템
US6907879B2 (en) 2002-02-04 2005-06-21 Ndt Agent delivery and aspiration device
CN2542262Y (zh) * 2002-08-26 2003-04-02 刘寿全 高压助推器
ES2327731T3 (es) 2002-09-24 2009-11-03 Shl Group Ab Dispositivo de inyeccion.
US7285255B2 (en) 2002-12-10 2007-10-23 Ecolab Inc. Deodorizing and sanitizing employing a wicking device
US20070073275A1 (en) 2003-04-16 2007-03-29 Conston Stanley R Ophthalmic microsurgical instruments
US6805015B1 (en) 2003-05-22 2004-10-19 H. Donald Schwartz Dual resolution syringe
BRPI0506837A (pt) 2004-01-12 2007-06-12 Iscience Surgical Corp injetor para materiais viscosos, e, dispositivos e kit para fornecer microquantidades de materiais viscosos
SG183072A1 (en) 2004-01-23 2012-08-30 Iscience Surgical Corp Composite ophthalmic microcannula
US20060173418A1 (en) 2004-12-13 2006-08-03 Arrow International, Inc. Loss of resistance syringe
US20070118093A1 (en) 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111249062A (zh) * 2012-07-03 2020-06-09 诺华股份有限公司 注射器
CN112312868A (zh) * 2018-04-12 2021-02-02 新世界医学有限公司 用于眼内流体注射的装置和方法
US11844934B2 (en) 2018-04-12 2023-12-19 New World Medical Inc. Device and method for intraocular fluid injection
CN112312868B (zh) * 2018-04-12 2023-12-22 新世界医学有限公司 用于眼内流体注射的装置和方法
CN109939890A (zh) * 2018-12-04 2019-06-28 深圳市东信硅材料有限公司 一种点胶设备的压料装置

Also Published As

Publication number Publication date
CN1950124A (zh) 2007-04-18
US7967772B2 (en) 2011-06-28
EP1706172A2 (en) 2006-10-04
JP2012030087A (ja) 2012-02-16
CA2552966A1 (en) 2005-08-04
WO2005069831A2 (en) 2005-08-04
WO2005069831A3 (en) 2005-10-27
AU2005206872B2 (en) 2011-05-26
US20070287958A1 (en) 2007-12-13
EP1706172A4 (en) 2012-05-30
JP2007520276A (ja) 2007-07-26
CA2552966C (en) 2012-10-30
CN1950124B (zh) 2010-11-10
KR20060130648A (ko) 2006-12-19
AU2005206872A1 (en) 2005-08-04
BRPI0506837A (pt) 2007-06-12

Similar Documents

Publication Publication Date Title
CN1950124B (zh) 一种输送粘性材料的注射器
AU618999B2 (en) Constant pressure variable flow pump
US9987163B2 (en) Device for dispensing intraocular substances
JP6839240B2 (ja) 液剤を投薬する用計量システムを有するポンプ・エンジン
JP4756077B2 (ja) 注入ポンプ及びその使用方法
US6277096B1 (en) Digital fluid delivery and aspiration apparatus with mechanical de-amplifier
JP3633615B2 (ja) 針を使用しない注射装置
US4437859A (en) Hydraulic syringe drive
RU2134592C1 (ru) Устройство для контролируемой подачи жидкости
WO2000038767A1 (en) Spring-powered infusion pump
US9907904B2 (en) Spring-driven drug delivery device
US20190388611A1 (en) Infusion device
WO2023141627A2 (en) Systems, devices, and methods for fluidic throttle control of the delivery of therapies in needle-based delivery systems
WO2020076777A1 (en) Drug-delivery systems including drug-delivery device assemblies for attaching to infusion needle hubs
BRMU8800226U2 (pt) disposição aplicada em seringa de precisão roscada

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20101215