CN101883778A - 具有糖皮质激素活性的甾类[3，2-c]吡唑化合物 - Google Patents

具有糖皮质激素活性的甾类[3，2-c]吡唑化合物 Download PDF

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Publication number
CN101883778A
CN101883778A CN2008801190932A CN200880119093A CN101883778A CN 101883778 A CN101883778 A CN 101883778A CN 2008801190932 A CN2008801190932 A CN 2008801190932A CN 200880119093 A CN200880119093 A CN 200880119093A CN 101883778 A CN101883778 A CN 101883778A
Authority
CN
China
Prior art keywords
naphtho
dimethyl
ester
carbonyl
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801190932A
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English (en)
Chinese (zh)
Inventor
哈坎·布雷德
弗兰克·伯坎普
巴林特·加伯斯
彼得·汉森
斯维特拉纳·伊万诺娃
卡罗琳娜·拉维茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101883778(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101883778A publication Critical patent/CN101883778A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801190932A 2007-10-04 2008-10-02 具有糖皮质激素活性的甾类[3，2-c]吡唑化合物 Pending CN101883778A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97741607P 2007-10-04 2007-10-04
US60/977,416 2007-10-04
PCT/GB2008/050890 WO2009044200A1 (en) 2007-10-04 2008-10-02 Steroidal [3, 2-c] pyrazole compounds, with glucocorticoid activity

Publications (1)

Publication Number Publication Date
CN101883778A true CN101883778A (zh) 2010-11-10

Family

ID=40328402

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801190932A Pending CN101883778A (zh) 2007-10-04 2008-10-02 具有糖皮质激素活性的甾类[3，2-c]吡唑化合物

Country Status (23)

Country Link
US (2) US8163724B2 (enExample)
EP (1) EP2207788A1 (enExample)
JP (1) JP2010540612A (enExample)
KR (1) KR20100087147A (enExample)
CN (1) CN101883778A (enExample)
AR (1) AR068734A1 (enExample)
AU (1) AU2008306593C1 (enExample)
BR (1) BRPI0817941A2 (enExample)
CA (1) CA2700181A1 (enExample)
CL (1) CL2008002954A1 (enExample)
CO (1) CO6270214A2 (enExample)
CR (1) CR11345A (enExample)
DO (1) DOP2010000094A (enExample)
EA (1) EA201000436A1 (enExample)
IL (1) IL204611A0 (enExample)
MX (1) MX2010003698A (enExample)
NI (1) NI201000043A (enExample)
NZ (1) NZ584160A (enExample)
PE (1) PE20090776A1 (enExample)
TW (1) TW200918047A (enExample)
UY (1) UY31375A1 (enExample)
WO (1) WO2009044200A1 (enExample)
ZA (1) ZA201002223B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

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US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
TW201111392A (en) 2009-06-16 2011-04-01 Schering Corp Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
WO2012094618A1 (en) * 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
RU2600739C2 (ru) 2011-03-18 2016-10-27 Байер Интеллектчуал Проперти Гмбх N-(3-карбамоилфенил)-1н-пиразол-5-карбоксамидные производные и их применение для борьбы с животными-вредителями
US9526729B2 (en) * 2013-01-29 2016-12-27 Hsiao Lily Yu Medicament for treating peripheral neuropathies
HK1222565A1 (zh) * 2013-09-25 2017-07-07 范安德尔研究所 高效糖皮質激素

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US20110160167A1 (en) 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
BRPI0907789A2 (pt) 2008-02-27 2019-01-22 Astrazeneca Ab derivaldos 16-alfa e 17-alfa de glicocorticosteroides e seus usos
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制
CN110382033B (zh) * 2016-10-14 2022-04-15 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

Also Published As

Publication number Publication date
US20120178726A1 (en) 2012-07-12
EA201000436A1 (ru) 2010-10-29
CO6270214A2 (es) 2011-04-20
DOP2010000094A (es) 2012-08-15
JP2010540612A (ja) 2010-12-24
MX2010003698A (es) 2010-04-21
AU2008306593B2 (en) 2012-04-12
CR11345A (es) 2010-07-15
KR20100087147A (ko) 2010-08-03
UY31375A1 (es) 2009-05-29
WO2009044200A1 (en) 2009-04-09
US20090286835A1 (en) 2009-11-19
CA2700181A1 (en) 2009-04-09
AR068734A1 (es) 2009-12-02
PE20090776A1 (es) 2009-07-23
AU2008306593A1 (en) 2009-04-09
AU2008306593C1 (en) 2012-10-04
ZA201002223B (en) 2010-12-29
NI201000043A (es) 2012-09-10
TW200918047A (en) 2009-05-01
BRPI0817941A2 (pt) 2015-05-05
EP2207788A1 (en) 2010-07-21
CL2008002954A1 (es) 2010-01-15
IL204611A0 (en) 2010-11-30
US8163724B2 (en) 2012-04-24
NZ584160A (en) 2011-05-27

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