EA201000436A1 - Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью - Google Patents

Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью

Info

Publication number
EA201000436A1
EA201000436A1 EA201000436A EA201000436A EA201000436A1 EA 201000436 A1 EA201000436 A1 EA 201000436A1 EA 201000436 A EA201000436 A EA 201000436A EA 201000436 A EA201000436 A EA 201000436A EA 201000436 A1 EA201000436 A1 EA 201000436A1
Authority
EA
Eurasian Patent Office
Prior art keywords
steroid
glucocorticoid activity
compounds
pyrazolic
pyrazolic compounds
Prior art date
Application number
EA201000436A
Other languages
English (en)
Russian (ru)
Inventor
Хокан Бладх
Франк Буркамп
Балинт Габос
Петер Хансен
Светлана Иванова
Каролина Лавиц
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000436(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201000436A1 publication Critical patent/EA201000436A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA201000436A 2007-10-04 2008-10-02 Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью EA201000436A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97741607P 2007-10-04 2007-10-04
PCT/GB2008/050890 WO2009044200A1 (en) 2007-10-04 2008-10-02 Steroidal [3, 2-c] pyrazole compounds, with glucocorticoid activity

Publications (1)

Publication Number Publication Date
EA201000436A1 true EA201000436A1 (ru) 2010-10-29

Family

ID=40328402

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000436A EA201000436A1 (ru) 2007-10-04 2008-10-02 Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью

Country Status (23)

Country Link
US (2) US8163724B2 (enExample)
EP (1) EP2207788A1 (enExample)
JP (1) JP2010540612A (enExample)
KR (1) KR20100087147A (enExample)
CN (1) CN101883778A (enExample)
AR (1) AR068734A1 (enExample)
AU (1) AU2008306593C1 (enExample)
BR (1) BRPI0817941A2 (enExample)
CA (1) CA2700181A1 (enExample)
CL (1) CL2008002954A1 (enExample)
CO (1) CO6270214A2 (enExample)
CR (1) CR11345A (enExample)
DO (1) DOP2010000094A (enExample)
EA (1) EA201000436A1 (enExample)
IL (1) IL204611A0 (enExample)
MX (1) MX2010003698A (enExample)
NI (1) NI201000043A (enExample)
NZ (1) NZ584160A (enExample)
PE (1) PE20090776A1 (enExample)
TW (1) TW200918047A (enExample)
UY (1) UY31375A1 (enExample)
WO (1) WO2009044200A1 (enExample)
ZA (1) ZA201002223B (enExample)

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US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
TW201111392A (en) 2009-06-16 2011-04-01 Schering Corp Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
WO2012094618A1 (en) * 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
RU2600739C2 (ru) 2011-03-18 2016-10-27 Байер Интеллектчуал Проперти Гмбх N-(3-карбамоилфенил)-1н-пиразол-5-карбоксамидные производные и их применение для борьбы с животными-вредителями
US9526729B2 (en) * 2013-01-29 2016-12-27 Hsiao Lily Yu Medicament for treating peripheral neuropathies
HK1222565A1 (zh) * 2013-09-25 2017-07-07 范安德尔研究所 高效糖皮質激素
US10954265B2 (en) * 2016-10-14 2021-03-23 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids

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US3364203A (en) 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
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SE8306370D0 (sv) 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
WO1994025478A1 (en) 1993-04-29 1994-11-10 Instytut Farmaceutyczny 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES
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MX2010003698A (es) 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
US20110160167A1 (en) 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
BRPI0907789A2 (pt) 2008-02-27 2019-01-22 Astrazeneca Ab derivaldos 16-alfa e 17-alfa de glicocorticosteroides e seus usos
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Also Published As

Publication number Publication date
US20120178726A1 (en) 2012-07-12
CO6270214A2 (es) 2011-04-20
DOP2010000094A (es) 2012-08-15
JP2010540612A (ja) 2010-12-24
MX2010003698A (es) 2010-04-21
AU2008306593B2 (en) 2012-04-12
CR11345A (es) 2010-07-15
CN101883778A (zh) 2010-11-10
KR20100087147A (ko) 2010-08-03
UY31375A1 (es) 2009-05-29
WO2009044200A1 (en) 2009-04-09
US20090286835A1 (en) 2009-11-19
CA2700181A1 (en) 2009-04-09
AR068734A1 (es) 2009-12-02
PE20090776A1 (es) 2009-07-23
AU2008306593A1 (en) 2009-04-09
AU2008306593C1 (en) 2012-10-04
ZA201002223B (en) 2010-12-29
NI201000043A (es) 2012-09-10
TW200918047A (en) 2009-05-01
BRPI0817941A2 (pt) 2015-05-05
EP2207788A1 (en) 2010-07-21
CL2008002954A1 (es) 2010-01-15
IL204611A0 (en) 2010-11-30
US8163724B2 (en) 2012-04-24
NZ584160A (en) 2011-05-27

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