UY31375A1 - Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione - Google Patents
Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicioneInfo
- Publication number
- UY31375A1 UY31375A1 UY31375A UY31375A UY31375A1 UY 31375 A1 UY31375 A1 UY 31375A1 UY 31375 A UY31375 A UY 31375A UY 31375 A UY31375 A UY 31375A UY 31375 A1 UY31375 A1 UY 31375A1
- Authority
- UY
- Uruguay
- Prior art keywords
- tetradecahydrociclopenta
- nafto
- dimetil
- esteres
- hidroxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona compuestos de formula (I) en donde n, p, R1, R2, X1, X2, X3, R3a, R3b, R4, R5 y R6 son como se definen en la memoria descriptiva, un procedimiento para la preparacion de los mismos, composiciones farmacéuticas que los contienen y su utilizacion en terapia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97741607P | 2007-10-04 | 2007-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31375A1 true UY31375A1 (es) | 2009-05-29 |
Family
ID=40328402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31375A UY31375A1 (es) | 2007-10-04 | 2008-10-03 | Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione |
Country Status (23)
Country | Link |
---|---|
US (2) | US8163724B2 (es) |
EP (1) | EP2207788A1 (es) |
JP (1) | JP2010540612A (es) |
KR (1) | KR20100087147A (es) |
CN (1) | CN101883778A (es) |
AR (1) | AR068734A1 (es) |
AU (1) | AU2008306593C1 (es) |
BR (1) | BRPI0817941A2 (es) |
CA (1) | CA2700181A1 (es) |
CL (1) | CL2008002954A1 (es) |
CO (1) | CO6270214A2 (es) |
CR (1) | CR11345A (es) |
DO (1) | DOP2010000094A (es) |
EA (1) | EA201000436A1 (es) |
IL (1) | IL204611A0 (es) |
MX (1) | MX2010003698A (es) |
NI (1) | NI201000043A (es) |
NZ (1) | NZ584160A (es) |
PE (1) | PE20090776A1 (es) |
TW (1) | TW200918047A (es) |
UY (1) | UY31375A1 (es) |
WO (1) | WO2009044200A1 (es) |
ZA (1) | ZA201002223B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0817941A2 (pt) | 2007-10-04 | 2015-05-05 | Astrazeneca Ab | Compostos de pirazol de [3,2-c] esteroidais, com atividade glucocorticóide |
JP2011507836A (ja) * | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | グルココルチコステロイド受容体アゴニストとして作用するステロイド誘導体 |
UY32525A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
UY32521A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
AR077101A1 (es) * | 2009-06-16 | 2011-08-03 | Schering Corp | Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos |
GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
GB201016912D0 (en) * | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
US8829024B2 (en) * | 2011-01-07 | 2014-09-09 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
KR101834362B1 (ko) | 2011-03-18 | 2018-03-05 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | N-(3-카바모일페닐)-1h-피라졸-5-카복사미드 유도체 및 동물 해충을 구제하기 위한 그의 용도 |
US9526729B2 (en) * | 2013-01-29 | 2016-12-27 | Hsiao Lily Yu | Medicament for treating peripheral neuropathies |
WO2015048316A1 (en) * | 2013-09-25 | 2015-04-02 | Van Andel Research Institute | Highly potent glucocorticoids |
CN110382033B (zh) | 2016-10-14 | 2022-04-15 | 范安德尔研究所 | 用于设计高效力糖皮质激素的结构与机制 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB933867A (en) | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Fluorinated steroids |
NL237293A (es) | 1959-02-16 | |||
US3129218A (en) | 1961-11-01 | 1964-04-14 | Merck & Co Inc | 2-alkoxymethylene steroids of the androstane and pregnane series |
US3072639A (en) | 1962-03-05 | 1963-01-08 | Merck & Co Inc | 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them |
US3364203A (en) | 1965-09-09 | 1968-01-16 | Syntex Corp | 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation |
US3471477A (en) | 1967-10-18 | 1969-10-07 | Syntex Corp | 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids |
DE2727367A1 (de) | 1977-06-14 | 1979-01-04 | Schering Ag | Neue kortikoide |
DE2735110A1 (de) | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
DE2817988A1 (de) | 1978-04-25 | 1979-11-08 | Hoechst Ag | Corticoid 17-alkylcarbonate und verfahren zu deren herstellung |
JPS6067495A (ja) | 1983-09-22 | 1985-04-17 | Ota Seiyaku Kk | ピラゾール誘導体 |
SE8306370D0 (sv) | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
WO1994025478A1 (en) | 1993-04-29 | 1994-11-10 | Instytut Farmaceutyczny | 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
KR19990082463A (ko) | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체 |
DK0885198T3 (da) | 1996-03-05 | 2002-03-25 | Astrazeneca Ab | 4-Anilinoquinazolinderivater |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
CA2406979A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
AU2001266233B2 (en) | 2000-07-07 | 2006-06-29 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
RU2003103603A (ru) | 2000-07-07 | 2004-08-20 | Энджиоджен Фармасьютикалз Лимитед (Gb) | Производные колхинола в качестве ингибиторов ангиогенеза |
GB0110411D0 (en) | 2001-04-27 | 2001-06-20 | Astrazeneca Ab | Chemical process |
AU2002253342B2 (en) * | 2001-04-30 | 2007-01-04 | Glaxo Group Limited | Novel anti-inflammatory androstane derivatives |
ITMI20022606A1 (it) | 2002-12-09 | 2004-06-10 | Farmabios Spa | Processo di sintesi di steroidi polialogenati. |
WO2005028495A1 (en) | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
WO2005063777A1 (en) | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
WO2007054974A2 (en) | 2005-09-28 | 2007-05-18 | Arch Pharmalab Limited | A green chemistry process for the preparation of pregnadiene esters |
BRPI0817941A2 (pt) | 2007-10-04 | 2015-05-05 | Astrazeneca Ab | Compostos de pirazol de [3,2-c] esteroidais, com atividade glucocorticóide |
JP2011507836A (ja) | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | グルココルチコステロイド受容体アゴニストとして作用するステロイド誘導体 |
AU2009217824A1 (en) | 2008-02-27 | 2009-09-03 | Astrazeneca Ab | 16 alpha, 17 alpha-acetal glucocorticosteroidal derivatives and their use |
UY32525A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
UY32521A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
UY32523A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
UY32520A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
-
2008
- 2008-10-02 BR BRPI0817941 patent/BRPI0817941A2/pt not_active IP Right Cessation
- 2008-10-02 KR KR1020107009780A patent/KR20100087147A/ko not_active Application Discontinuation
- 2008-10-02 NZ NZ584160A patent/NZ584160A/en not_active IP Right Cessation
- 2008-10-02 CN CN2008801190932A patent/CN101883778A/zh active Pending
- 2008-10-02 EP EP08806706A patent/EP2207788A1/en not_active Ceased
- 2008-10-02 EA EA201000436A patent/EA201000436A1/ru unknown
- 2008-10-02 AU AU2008306593A patent/AU2008306593C1/en not_active Ceased
- 2008-10-02 WO PCT/GB2008/050890 patent/WO2009044200A1/en active Application Filing
- 2008-10-02 JP JP2010527546A patent/JP2010540612A/ja active Pending
- 2008-10-02 MX MX2010003698A patent/MX2010003698A/es active IP Right Grant
- 2008-10-02 CA CA2700181A patent/CA2700181A1/en not_active Abandoned
- 2008-10-03 CL CL2008002954A patent/CL2008002954A1/es unknown
- 2008-10-03 US US12/245,275 patent/US8163724B2/en not_active Expired - Fee Related
- 2008-10-03 AR ARP080104343A patent/AR068734A1/es not_active Application Discontinuation
- 2008-10-03 TW TW097138109A patent/TW200918047A/zh unknown
- 2008-10-03 UY UY31375A patent/UY31375A1/es not_active Application Discontinuation
- 2008-10-03 PE PE2008001725A patent/PE20090776A1/es not_active Application Discontinuation
-
2010
- 2010-03-18 IL IL204611A patent/IL204611A0/en unknown
- 2010-03-26 NI NI201000043A patent/NI201000043A/es unknown
- 2010-03-29 ZA ZA2010/02223A patent/ZA201002223B/en unknown
- 2010-03-31 DO DO2010000094A patent/DOP2010000094A/es unknown
- 2010-04-05 CO CO10037849A patent/CO6270214A2/es not_active Application Discontinuation
- 2010-04-05 CR CR11345A patent/CR11345A/es not_active Application Discontinuation
-
2012
- 2012-03-12 US US13/417,626 patent/US20120178726A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0817941A2 (pt) | 2015-05-05 |
DOP2010000094A (es) | 2012-08-15 |
AU2008306593A1 (en) | 2009-04-09 |
US20120178726A1 (en) | 2012-07-12 |
AR068734A1 (es) | 2009-12-02 |
US8163724B2 (en) | 2012-04-24 |
TW200918047A (en) | 2009-05-01 |
ZA201002223B (en) | 2010-12-29 |
KR20100087147A (ko) | 2010-08-03 |
NI201000043A (es) | 2012-09-10 |
MX2010003698A (es) | 2010-04-21 |
EA201000436A1 (ru) | 2010-10-29 |
CL2008002954A1 (es) | 2010-01-15 |
CO6270214A2 (es) | 2011-04-20 |
AU2008306593B2 (en) | 2012-04-12 |
CN101883778A (zh) | 2010-11-10 |
AU2008306593C1 (en) | 2012-10-04 |
JP2010540612A (ja) | 2010-12-24 |
EP2207788A1 (en) | 2010-07-21 |
WO2009044200A1 (en) | 2009-04-09 |
PE20090776A1 (es) | 2009-07-23 |
CR11345A (es) | 2010-07-15 |
US20090286835A1 (en) | 2009-11-19 |
NZ584160A (en) | 2011-05-27 |
CA2700181A1 (en) | 2009-04-09 |
IL204611A0 (en) | 2010-11-30 |
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Legal Events
Date | Code | Title | Description |
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109 | Application deemed to be withdrawn |
Effective date: 20171019 |