UY31375A1 - Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione - Google Patents

Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione

Info

Publication number
UY31375A1
UY31375A1 UY31375A UY31375A UY31375A1 UY 31375 A1 UY31375 A1 UY 31375A1 UY 31375 A UY31375 A UY 31375A UY 31375 A UY31375 A UY 31375A UY 31375 A1 UY31375 A1 UY 31375A1
Authority
UY
Uruguay
Prior art keywords
tetradecahydrociclopenta
nafto
dimetil
esteres
hidroxi
Prior art date
Application number
UY31375A
Other languages
English (en)
Inventor
Frank Burkamp
Peter Hansen
Balint Gabos
Svetlana Ivanova
Hakan Bladh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31375(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of UY31375A1 publication Critical patent/UY31375A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de formula (I) en donde n, p, R1, R2, X1, X2, X3, R3a, R3b, R4, R5 y R6 son como se definen en la memoria descriptiva, un procedimiento para la preparacion de los mismos, composiciones farmacéuticas que los contienen y su utilizacion en terapia.
UY31375A 2007-10-04 2008-10-03 Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione UY31375A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97741607P 2007-10-04 2007-10-04

Publications (1)

Publication Number Publication Date
UY31375A1 true UY31375A1 (es) 2009-05-29

Family

ID=40328402

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31375A UY31375A1 (es) 2007-10-04 2008-10-03 Derivados sustituidos de (1r, 3as, 3bs, 10ar, 10bs, 11s, 12as)-11-hidroxi-10a, 12a-dimetil-1,2,3,3a,3b, 4,5,7,10,10a,10b, 11,12, 12a tetradecahidrociclopenta [5,6] nafto[1,2-f]indazol-1-il esteres, sus sales farmacéuticamente aceptables, composicione

Country Status (23)

Country Link
US (2) US8163724B2 (es)
EP (1) EP2207788A1 (es)
JP (1) JP2010540612A (es)
KR (1) KR20100087147A (es)
CN (1) CN101883778A (es)
AR (1) AR068734A1 (es)
AU (1) AU2008306593C1 (es)
BR (1) BRPI0817941A2 (es)
CA (1) CA2700181A1 (es)
CL (1) CL2008002954A1 (es)
CO (1) CO6270214A2 (es)
CR (1) CR11345A (es)
DO (1) DOP2010000094A (es)
EA (1) EA201000436A1 (es)
IL (1) IL204611A0 (es)
MX (1) MX2010003698A (es)
NI (1) NI201000043A (es)
NZ (1) NZ584160A (es)
PE (1) PE20090776A1 (es)
TW (1) TW200918047A (es)
UY (1) UY31375A1 (es)
WO (1) WO2009044200A1 (es)
ZA (1) ZA201002223B (es)

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BRPI0817941A2 (pt) 2007-10-04 2015-05-05 Astrazeneca Ab Compostos de pirazol de [3,2-c] esteroidais, com atividade glucocorticóide
JP2011507836A (ja) * 2007-12-20 2011-03-10 アストラゼネカ・アクチエボラーグ グルココルチコステロイド受容体アゴニストとして作用するステロイド誘導体
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
AR077101A1 (es) * 2009-06-16 2011-08-03 Schering Corp Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
GB201016912D0 (en) * 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
US8829024B2 (en) * 2011-01-07 2014-09-09 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
KR101834362B1 (ko) 2011-03-18 2018-03-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 N-(3-카바모일페닐)-1h-피라졸-5-카복사미드 유도체 및 동물 해충을 구제하기 위한 그의 용도
US9526729B2 (en) * 2013-01-29 2016-12-27 Hsiao Lily Yu Medicament for treating peripheral neuropathies
WO2015048316A1 (en) * 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
CN110382033B (zh) 2016-10-14 2022-04-15 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

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UY32521A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides

Also Published As

Publication number Publication date
BRPI0817941A2 (pt) 2015-05-05
DOP2010000094A (es) 2012-08-15
AU2008306593A1 (en) 2009-04-09
US20120178726A1 (en) 2012-07-12
AR068734A1 (es) 2009-12-02
US8163724B2 (en) 2012-04-24
TW200918047A (en) 2009-05-01
ZA201002223B (en) 2010-12-29
KR20100087147A (ko) 2010-08-03
NI201000043A (es) 2012-09-10
MX2010003698A (es) 2010-04-21
EA201000436A1 (ru) 2010-10-29
CL2008002954A1 (es) 2010-01-15
CO6270214A2 (es) 2011-04-20
AU2008306593B2 (en) 2012-04-12
CN101883778A (zh) 2010-11-10
AU2008306593C1 (en) 2012-10-04
JP2010540612A (ja) 2010-12-24
EP2207788A1 (en) 2010-07-21
WO2009044200A1 (en) 2009-04-09
PE20090776A1 (es) 2009-07-23
CR11345A (es) 2010-07-15
US20090286835A1 (en) 2009-11-19
NZ584160A (en) 2011-05-27
CA2700181A1 (en) 2009-04-09
IL204611A0 (en) 2010-11-30

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Legal Events

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Effective date: 20171019