CN101808516B - 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 - Google Patents

作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 Download PDF

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CN101808516B
CN101808516B CN2008801088296A CN200880108829A CN101808516B CN 101808516 B CN101808516 B CN 101808516B CN 2008801088296 A CN2008801088296 A CN 2008801088296A CN 200880108829 A CN200880108829 A CN 200880108829A CN 101808516 B CN101808516 B CN 101808516B
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additional embodiments
compound
cancer
formula
alkyl
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CN101808516A (zh
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J-M·韦尼耶
C·E·罗林斯
J-l·吉拉德特
S·迪莫克
B·夸尔特
J·N·迈纳
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Ardea Biociences Inc
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Priority claimed from US11/830,733 external-priority patent/US8101799B2/en
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Priority to CN201310317815.8A priority Critical patent/CN103479604B/zh
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    • C—CHEMISTRY; METALLURGY
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
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    • A01N41/04—Sulfonic acids; Derivatives thereof
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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  • Epidemiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Agronomy & Crop Science (AREA)
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  • Urology & Nephrology (AREA)
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  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pest Control & Pesticides (AREA)
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CN2008801088296A 2007-07-30 2008-07-28 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 Expired - Fee Related CN101808516B (zh)

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Application Number Priority Date Filing Date Title
CN201310317815.8A CN103479604B (zh) 2007-07-30 2008-07-28 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11/830,733 2007-07-30
US11/830,733 US8101799B2 (en) 2005-07-21 2007-07-30 Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
US3446608P 2008-03-06 2008-03-06
US3446408P 2008-03-06 2008-03-06
US61/034,466 2008-03-06
US61/034,464 2008-03-06
US4488608P 2008-04-14 2008-04-14
US61/044,886 2008-04-14
PCT/US2008/071392 WO2009018233A1 (en) 2007-07-30 2008-07-28 Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

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CN201310317815.8A Division CN103479604B (zh) 2007-07-30 2008-07-28 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法

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CN101808516A CN101808516A (zh) 2010-08-18
CN101808516B true CN101808516B (zh) 2013-08-28

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CN201310317815.8A Expired - Fee Related CN103479604B (zh) 2007-07-30 2008-07-28 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法

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EP (1) EP2184984A4 (enExample)
JP (3) JP2010535232A (enExample)
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CO6470808A2 (es) 2012-06-29
JP2017125021A (ja) 2017-07-20
CR11244A (es) 2010-05-20
TN2010000049A1 (en) 2011-09-26
SV2010003469A (es) 2010-04-30
EA020624B1 (ru) 2014-12-30
MX2010001244A (es) 2010-08-31
EA032294B1 (ru) 2019-05-31
IL203296A (en) 2017-06-29
EP2184984A4 (en) 2013-07-24
CA2693390C (en) 2017-01-17
MA31881B1 (fr) 2010-12-01
EA201400552A1 (ru) 2014-09-30
CA2693390A1 (en) 2009-02-05
HK1147396A1 (en) 2011-08-12
AP2817A (en) 2013-12-31
PH12015501914A1 (en) 2017-07-31
WO2009018233A1 (en) 2009-02-05
BRPI0815659A2 (pt) 2014-09-30
DOP2010000045A (es) 2010-10-31
CN101808516A (zh) 2010-08-18
KR20100092424A (ko) 2010-08-20
CN103479604B (zh) 2016-08-10
CN103479604A (zh) 2014-01-01
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