CN101799476B - 筛选针对tsh受体的自身抗体的试剂盒 - Google Patents

筛选针对tsh受体的自身抗体的试剂盒 Download PDF

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Publication number
CN101799476B
CN101799476B CN2010101273436A CN201010127343A CN101799476B CN 101799476 B CN101799476 B CN 101799476B CN 2010101273436 A CN2010101273436 A CN 2010101273436A CN 201010127343 A CN201010127343 A CN 201010127343A CN 101799476 B CN101799476 B CN 101799476B
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tsh receptor
autoantibody
amino acids
tsh
amino acid
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Expired - Lifetime
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CN101799476A (zh
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伯纳德·里斯·史密斯
雅德维加·富尔马尼亚克
简·菲娜·桑德斯
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RSR Ltd
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Priority claimed from GB0215212A external-priority patent/GB0215212D0/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Biotechnology (AREA)
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  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
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CN2010101273436A 2001-08-23 2002-08-21 筛选针对tsh受体的自身抗体的试剂盒 Expired - Lifetime CN101799476B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0120649A GB0120649D0 (en) 2001-08-23 2001-08-23 Epitope regions of a thyrotrophin (TSH) receptor and uses thereof
GB0120649.9 2001-08-23
GB0215212.2 2002-07-01
GB0215212A GB0215212D0 (en) 2002-07-01 2002-07-01 Epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto

Related Parent Applications (1)

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CN028164229A Division CN1622958B (zh) 2001-08-23 2002-08-21 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体

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CN101799476A CN101799476A (zh) 2010-08-11
CN101799476B true CN101799476B (zh) 2013-01-02

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CN2010101273436A Expired - Lifetime CN101799476B (zh) 2001-08-23 2002-08-21 筛选针对tsh受体的自身抗体的试剂盒
CN201310075812.8A Expired - Lifetime CN103224562B (zh) 2001-08-23 2002-08-21 促甲状腺素受体的表位区域和针对该区域的抗体
CN028164229A Expired - Lifetime CN1622958B (zh) 2001-08-23 2002-08-21 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体

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CN201310075812.8A Expired - Lifetime CN103224562B (zh) 2001-08-23 2002-08-21 促甲状腺素受体的表位区域和针对该区域的抗体
CN028164229A Expired - Lifetime CN1622958B (zh) 2001-08-23 2002-08-21 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体

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US (4) US8298769B2 (OSRAM)
EP (3) EP1456234B1 (OSRAM)
JP (2) JP2005509412A (OSRAM)
CN (3) CN101799476B (OSRAM)
ES (3) ES2732276T3 (OSRAM)
WO (1) WO2003018632A2 (OSRAM)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101799476B (zh) 2001-08-23 2013-01-02 Rsr有限公司 筛选针对tsh受体的自身抗体的试剂盒
JP5314234B2 (ja) * 2002-11-29 2013-10-16 アールエスアール リミテッド チロトロピン受容体の結合対象及びその使用
EP1612224B1 (en) 2004-06-29 2012-03-07 B.R.A.H.M.S GmbH Novel monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine
GB0418181D0 (en) 2004-08-13 2004-09-15 Rsr Ltd Thyrotrophin receptor preparations,thyrotrophin receptor epitopes,antibody and hormone interactions therewith,and uses thereof
WO2007057778A2 (en) * 2005-11-21 2007-05-24 Dr. Fenning Biomed Gmbh Recombinant polypeptides and methods for detecting and/or quantifying autoantibodies against tsh receptor
JP5165672B2 (ja) * 2006-03-29 2013-03-21 キングス カレッジ ロンドン Tshrに対するアゴニスト抗体
ES2550158T3 (es) * 2007-08-06 2015-11-04 Chugai Seiyaku Kabushiki Kaisha Método para medir la actividad inhibidora sobre la unión ligando-receptor
EP2617735A3 (en) * 2008-12-24 2013-10-16 Rsr Limited Human anti tshr antibodies
KR101935088B1 (ko) 2012-08-24 2019-01-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신
EP3593812A3 (en) 2014-03-15 2020-05-27 Novartis AG Treatment of cancer using chimeric antigen receptor
EP3193915A1 (en) 2014-07-21 2017-07-26 Novartis AG Combinations of low, immune enhancing. doses of mtor inhibitors and cars
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US11161907B2 (en) 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
EP3286211A1 (en) 2015-04-23 2018-02-28 Novartis AG Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
US11667691B2 (en) 2015-08-07 2023-06-06 Novartis Ag Treatment of cancer using chimeric CD3 receptor proteins
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US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
IL299099B2 (en) 2016-06-27 2025-07-01 Univ California Cancer treatment combinations
WO2018111340A1 (en) 2016-12-16 2018-06-21 Novartis Ag Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
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WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
AU2018355427A1 (en) 2017-10-25 2020-04-30 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
US20210040205A1 (en) 2017-10-25 2021-02-11 Novartis Ag Antibodies targeting cd32b and methods of use thereof
WO2019210153A1 (en) 2018-04-27 2019-10-31 Novartis Ag Car t cell therapies with enhanced efficacy
WO2019213282A1 (en) 2018-05-01 2019-11-07 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
WO2019227003A1 (en) 2018-05-25 2019-11-28 Novartis Ag Combination therapy with chimeric antigen receptor (car) therapies
EP3802825A1 (en) 2018-06-08 2021-04-14 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
US12441815B2 (en) 2018-11-02 2025-10-14 The Regents Of The University Of California Compositions and methods for diagnosis of cardiovascular disease
US20240245670A1 (en) 2018-12-20 2024-07-25 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
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KR20220116522A (ko) 2019-12-20 2022-08-23 노파르티스 아게 증식성 질환의 치료를 위한 항-tgf-베타 항체 및 체크포인트 억제제의 용도
CA3185455A1 (en) 2020-06-11 2021-12-16 Novartis Ag Zbtb32 inhibitors and uses thereof
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TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
AU2022267891A1 (en) 2021-04-27 2023-11-09 Novartis Ag Viral vector production system
WO2023214325A1 (en) 2022-05-05 2023-11-09 Novartis Ag Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
KR20250057832A (ko) * 2022-08-31 2025-04-29 장춘 진사이언스 파마슈티컬 씨오., 엘티디. 갑상선 자극 호르몬 수용체에 결합하는 항체 및 이의 용도
WO2024089639A1 (en) 2022-10-26 2024-05-02 Novartis Ag Lentiviral formulations
AU2024276994A1 (en) 2023-05-24 2025-10-23 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814461A (en) * 1993-08-20 1998-09-29 B.R.A.H.M.S. Diagnostica Gmbh Method for the determination of anti-TSH receptor autoantibodies
EP0943098B1 (de) * 1996-12-09 2005-03-09 B.R.A.H.M.S Aktiengesellschaft Rezeptorbindungsassay zum nachweis von tsh-rezeptor-autoantikörpern
EP1021721B1 (en) * 1998-06-06 2006-08-09 Rsr Limited Assays for tsh receptor autoantibodies
EP1078986B1 (en) * 1999-08-24 2007-02-28 Tosoh Corporation Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244940A (en) 1978-09-05 1981-01-13 Bio-Rad Laboratories, Inc. Single-incubation two-site immunoassay
US4514498A (en) 1982-05-26 1985-04-30 The Board Of Regents, The University Of Texas System Hybrid cell lines producing monoclonal antibodies directed against Treponema
US4472508A (en) 1982-12-30 1984-09-18 The Beth Israel Hospital Association Test for detecting and measuring the graves' disease-specific immunoglobulins
WO1984003106A1 (en) 1983-02-04 1984-08-16 Wadley Inst Of Molecular Medic Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins
US4609622A (en) 1983-05-31 1986-09-02 Interthyr Research Foundation Inc. Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5
US4753894A (en) 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
US4661446A (en) 1985-02-19 1987-04-28 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies and method of immunizing therewith
WO1990008528A1 (en) 1989-01-11 1990-08-09 The United States Of America, Represented By The Secretary, United States Department Of Commerce Biologically active synthetic thyrotropin and cloned gene for producing same
DK0614975T3 (da) 1989-05-05 2002-11-11 Genentech Inc Glycoproteinhormonreceptormolekyler
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5744348A (en) 1989-09-08 1998-04-28 New England Medical Center Hospitals, Inc. TSH receptor
DE68927461T2 (de) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
WO1991009137A1 (en) 1989-12-20 1991-06-27 Basil Rapoport Recombinant thyrotropin receptor
JPH04149197A (ja) * 1990-10-12 1992-05-22 Tanabe Seiyaku Co Ltd 新規ペプチド
EP0482598A3 (en) 1990-10-24 1993-05-19 Ishihara Sangyo Kaisha, Ltd. Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism
US5578496A (en) 1991-12-19 1996-11-26 Board Of Regents, Baylor College Of Medicine Detection of autoantibodies associated with the disease myasthenia gravis
AU679439B2 (en) 1992-02-10 1997-07-03 Duke University Use of synthetic peptides to induce tolerance to pathogenic T and B cell epitopes of autoantigens
US5705400A (en) 1992-03-07 1998-01-06 Rsr Limited Assay for adrenal autoantigen
US5195860A (en) 1992-07-20 1993-03-23 Trw Inc. Push-on type fastener for automatic feed and installation equipment
JPH06220089A (ja) * 1993-01-27 1994-08-09 Ishihara Sangyo Kaisha Ltd ペプチド又はその塩並びにそれらを含有する自己免疫性甲状腺疾患の診断薬又は治療薬
WO1994018566A1 (fr) 1993-02-04 1994-08-18 Sumitomo Pharmaceuticals Company, Limited Procede de dosage d'un anticorps specifique
JPH0789991A (ja) * 1993-09-28 1995-04-04 Mitsubishi Chem Corp 新規なポリペプチドおよびそれを用いるtsh受容体抗体の測定法
EP0719858A3 (en) 1994-12-27 1997-12-29 Tosoh Corporation Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor
DE19505266C1 (de) 1995-02-16 1996-10-02 Brahms Diagnostica Gmbh Verwendung von polyklonalen humanen anti-hTg-Autoantikörpern als Reagenz für die klinische Diagnostik von Schilddrüsen-Autoimmunerkrankungen sowie Reagenziensatz für eine Bestimmung von anti-hTg-Autoantikörpern in Patientenseren
DE19522171C1 (de) 1995-06-19 1996-08-22 Brahms Diagnostica Gmbh Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern
US5723343A (en) 1995-08-28 1998-03-03 University Of Florida Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor
DE19728991A1 (de) 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
US5734464A (en) 1996-11-06 1998-03-31 Cobe Laboratories, Inc. Red blood cell spillover detection technique
US6692625B1 (en) 1996-11-06 2004-02-17 Robert Bosch Gmbh Electrochemical sensor
IL123888A0 (en) 1997-04-01 1998-10-30 Sankyo Co Anti-fas antibodies
WO2000005345A1 (en) * 1998-07-21 2000-02-03 Basil Rapoport Human thyrotropin receptor compositions and use thereof
GB9823397D0 (en) * 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
JP4427878B2 (ja) * 1999-08-20 2010-03-10 味の素株式会社 析出を伴う発酵法によるl−グルタミン酸の製造法
ES2248133T3 (es) 1999-10-12 2006-03-16 Ulrich Loos Procedimiento para la determinacion de autoanticuerpos contra el receptor de tsh.
WO2001044300A2 (en) 1999-12-13 2001-06-21 Cambridge Antibody Technology Limited Brain specific binding members
DE50106201D1 (de) 2000-02-21 2005-06-16 Brahms Ag Verfahren zur differentialdiagnostischen bestimmung von gegen den tsh-rezeptor gebildeten autoantikörpern in einer serum- oder plasmaprobe eines patienten
JP5198704B2 (ja) 2000-03-03 2013-05-15 メディミューン リミティド エオタキシンに対するヒト抗体及びそれらの使用
US20020103345A1 (en) 2000-05-24 2002-08-01 Zhenping Zhu Bispecific immunoglobulin-like antigen binding proteins and method of production
DE10126968A1 (de) 2001-06-01 2002-12-12 Ivoclar Vivadent Ag Farbstoffzusammensetzung zum individuellen Einfärben von Prothesenkunststoffen
CN101799476B (zh) 2001-08-23 2013-01-02 Rsr有限公司 筛选针对tsh受体的自身抗体的试剂盒
JP5314234B2 (ja) 2002-11-29 2013-10-16 アールエスアール リミテッド チロトロピン受容体の結合対象及びその使用
US8840891B2 (en) * 2007-02-15 2014-09-23 Rsr Limited Human monoclonal antibodies to the thyrotropin receptor which act as antagonists
EP2617735A3 (en) * 2008-12-24 2013-10-16 Rsr Limited Human anti tshr antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814461A (en) * 1993-08-20 1998-09-29 B.R.A.H.M.S. Diagnostica Gmbh Method for the determination of anti-TSH receptor autoantibodies
EP0943098B1 (de) * 1996-12-09 2005-03-09 B.R.A.H.M.S Aktiengesellschaft Rezeptorbindungsassay zum nachweis von tsh-rezeptor-autoantikörpern
EP1021721B1 (en) * 1998-06-06 2006-08-09 Rsr Limited Assays for tsh receptor autoantibodies
EP1078986B1 (en) * 1999-08-24 2007-02-28 Tosoh Corporation Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same

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