CN1017901B - 抗精神病药稠环吡啶基哌嗪衍生物的制备方法 - Google Patents

抗精神病药稠环吡啶基哌嗪衍生物的制备方法

Info

Publication number
CN1017901B
CN1017901B CN86103071A CN86103071A CN1017901B CN 1017901 B CN1017901 B CN 1017901B CN 86103071 A CN86103071 A CN 86103071A CN 86103071 A CN86103071 A CN 86103071A CN 1017901 B CN1017901 B CN 1017901B
Authority
CN
China
Prior art keywords
formula
compound
butyl
pyridin
piperazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN86103071A
Other languages
English (en)
Chinese (zh)
Other versions
CN86103071A (zh
Inventor
詹姆斯·斯蒂瓦特·纽
约瑟夫·P·伊维克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CN86103071A publication Critical patent/CN86103071A/zh
Priority to CN 91105826 priority Critical patent/CN1021631C/zh
Publication of CN1017901B publication Critical patent/CN1017901B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN86103071A 1985-05-06 1986-05-05 抗精神病药稠环吡啶基哌嗪衍生物的制备方法 Expired CN1017901B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 91105826 CN1021631C (zh) 1985-05-06 1991-08-19 含稠环吡啶基哌嗪衍生物的抗精神病药的制备方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06
US731,201 1985-05-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 91105826 Division CN1021631C (zh) 1985-05-06 1991-08-19 含稠环吡啶基哌嗪衍生物的抗精神病药的制备方法

Publications (2)

Publication Number Publication Date
CN86103071A CN86103071A (zh) 1987-03-18
CN1017901B true CN1017901B (zh) 1992-08-19

Family

ID=24938510

Family Applications (1)

Application Number Title Priority Date Filing Date
CN86103071A Expired CN1017901B (zh) 1985-05-06 1986-05-05 抗精神病药稠环吡啶基哌嗪衍生物的制备方法

Country Status (25)

Country Link
JP (1) JPH0753728B2 (cg-RX-API-DMAC7.html)
KR (1) KR940000829B1 (cg-RX-API-DMAC7.html)
CN (1) CN1017901B (cg-RX-API-DMAC7.html)
AT (1) AT398572B (cg-RX-API-DMAC7.html)
AU (1) AU593244B2 (cg-RX-API-DMAC7.html)
BE (1) BE904724A (cg-RX-API-DMAC7.html)
CA (1) CA1278792C (cg-RX-API-DMAC7.html)
CH (1) CH672787A5 (cg-RX-API-DMAC7.html)
DE (1) DE3615180C2 (cg-RX-API-DMAC7.html)
DK (1) DK165745C (cg-RX-API-DMAC7.html)
EG (1) EG18206A (cg-RX-API-DMAC7.html)
ES (6) ES8801250A1 (cg-RX-API-DMAC7.html)
FI (1) FI85484C (cg-RX-API-DMAC7.html)
FR (1) FR2581385B1 (cg-RX-API-DMAC7.html)
GB (1) GB2174703B (cg-RX-API-DMAC7.html)
GR (1) GR861149B (cg-RX-API-DMAC7.html)
HU (1) HU195509B (cg-RX-API-DMAC7.html)
IE (1) IE59201B1 (cg-RX-API-DMAC7.html)
IT (1) IT1208607B (cg-RX-API-DMAC7.html)
LU (1) LU86421A1 (cg-RX-API-DMAC7.html)
MY (1) MY100777A (cg-RX-API-DMAC7.html)
NL (1) NL8601146A (cg-RX-API-DMAC7.html)
PT (1) PT82523B (cg-RX-API-DMAC7.html)
SE (1) SE465270B (cg-RX-API-DMAC7.html)
ZA (1) ZA862046B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
HU222745B1 (hu) * 1995-09-15 2003-09-29 Sanofi-Synthelabo Kinolin-2(1H)-on-származékok mint szerotonin antagonisták, elżállításuk és alkalmazásuk
FR2738824B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1 -yl)alkyl)-3,4-dihydroquinazolin-2(1h)-one,leur preparation et leur application en therapeutique
FR2738822B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
CA1278792C (en) 1991-01-08
FR2581385B1 (fr) 1991-10-04
FI85484B (fi) 1992-01-15
ATA121486A (de) 1994-05-15
GB2174703B (en) 1988-10-26
IT1208607B (it) 1989-07-10
NL8601146A (nl) 1986-12-01
JPH0753728B2 (ja) 1995-06-07
KR860009008A (ko) 1986-12-19
FR2581385A1 (fr) 1986-11-07
AT398572B (de) 1994-12-27
ES557757A0 (es) 1988-04-01
BE904724A (fr) 1986-11-05
ES557839A0 (es) 1989-01-16
GR861149B (en) 1986-09-09
DK165745C (da) 1993-06-14
ES9000005A1 (es) 1989-11-01
ES557809A0 (es) 1988-09-01
AU5679586A (en) 1986-11-13
HU195509B (en) 1988-05-30
DK207186D0 (da) 1986-05-05
DE3615180A1 (de) 1986-11-06
IE59201B1 (en) 1994-01-26
IT8620313A0 (it) 1986-05-06
ES8802149A1 (es) 1988-04-01
PT82523A (en) 1986-06-01
CN86103071A (zh) 1987-03-18
GB2174703A (en) 1986-11-12
MY100777A (en) 1991-02-14
SE465270B (sv) 1991-08-19
FI85484C (fi) 1992-04-27
CH672787A5 (cg-RX-API-DMAC7.html) 1989-12-29
EG18206A (en) 1992-09-30
SE8602061D0 (sv) 1986-05-05
HUT43848A (en) 1987-12-28
IE861193L (en) 1986-11-06
JPS61268681A (ja) 1986-11-28
ES554659A0 (es) 1987-12-16
AU593244B2 (en) 1990-02-08
ZA862046B (en) 1986-11-26
ES557855A0 (es) 1989-05-16
DK207186A (da) 1986-11-07
ES8801250A1 (es) 1987-12-16
PT82523B (pt) 1988-10-14
ES8900138A1 (es) 1989-01-16
SE8602061L (sv) 1986-11-07
ES8802614A1 (es) 1988-09-01
GB8610810D0 (en) 1986-06-11
ES8900253A1 (es) 1989-05-16
FI861820A0 (fi) 1986-04-30
DK165745B (da) 1993-01-11
FI861820A7 (fi) 1986-11-07
KR940000829B1 (ko) 1994-02-02
LU86421A1 (fr) 1986-12-05
DE3615180C2 (de) 1996-03-07

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C17 Cessation of patent right
CX01 Expiry of patent term