CN101759548A - 一种使用超临界co2萃取大黄中大黄素的制备工艺 - Google Patents
一种使用超临界co2萃取大黄中大黄素的制备工艺 Download PDFInfo
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- CN101759548A CN101759548A CN200910218241A CN200910218241A CN101759548A CN 101759548 A CN101759548 A CN 101759548A CN 200910218241 A CN200910218241 A CN 200910218241A CN 200910218241 A CN200910218241 A CN 200910218241A CN 101759548 A CN101759548 A CN 101759548A
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- rheum officinale
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- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 240000004980 Rheum officinale Species 0.000 title claims abstract description 38
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
试验因素 | A萃取温度 | B萃取压力 | C萃取时间 |
水平编码 | ℃ | MPa | h |
-1 | 32 | 20 | 2 |
0 | 40 | 30 | 3 |
1 | 48 | 40 | 4 |
组别 | A:温度℃ | B:压力MPa | C:时间h | 粗提取g(实测值) | 粗提取物g(预测值) |
1 | -1 | -1 | 0 | 0.40 | 0.40 |
2 | 1 | -1 | 0 | 0.67 | 0.70 |
3 | -1 | 1 | 0 | 0.43 | 0.40 |
4 | 1 | 1 | 0 | 0.49 | 0.49 |
5 | -1 | 0 | -1 | 0.42 | 0.48 |
6 | 1 | 0 | -1 | 0.47 | 0.49 |
7 | -1 | 0 | 1 | 0.49 | 0.47 |
8 | 1 | 0 | 1 | 0.91 | 0.85 |
9 | 0 | -1 | -1 | 0.43 | 0.38 |
组别 | A:温度℃ | B:压力MPa | C:时间h | 粗提取g(实测值) | 粗提取物g(预测值) |
10 | 0 | 1 | -1 | 0.32 | 0.30 |
11 | 0 | -1 | 1 | 0.55 | 0.58 |
12 | 0 | 1 | 1 | 0.40 | 0.45 |
13 | 0 | 0 | 0 | 0.23 | 0.23 |
14 | 0 | 0 | 0 | 0.21 | 0.23 |
15 | 0 | 0 | 0 | 0.20 | 0.23 |
16 | 0 | 0 | 0 | 0.25 | 0.23 |
17 | 0 | 0 | 0 | 0.27 | 0.23 |
变异数 | 平方和 | 自由度 | 均方 | F值 | P值 |
模型 | 0.50 | 9 | 0.056 | 20.34 | 0.0003 |
失拟项 | 0.016 | 3 | 0.005325 | 6.49 | 0.0512 |
误差项 | 0.003280 | 4 | 0.0008200 | ||
总和 | 0.52 | 16 | R=0.9814 | R2=0.9632 | R2 adj=0.9158 |
试验号 | 原料量g | 提取物g | 提取率% |
1 | 750 | 118 | 15.7 |
2 | 750 | 115 | 15.4 |
处理号 | 萃取压力(Mpa) | 萃取温度(℃) | 夹带剂 | 空列 | 得率% | 5%显著水平 |
01 | 15 | 30 | 正己烷 | 1 | 13.4962 | b |
02 | 20 | 40 | 石油醚 | 2 | 13.0182 | c |
03 | 15 | 50 | 丙酮 | 3 | 11.2402 | c |
04 | 30 | 30 | 石油醚 | 3 | 11.7419 | d |
05 | 30 | 40 | 丙酮 | 1 | 13.5662 | b |
06 | 30 | 50 | 正己烷 | 2 | 11.7593 | d |
07 | 35 | 30 | 丙酮 | 2 | 13.4123 | b |
处理号 | 萃取压力(Mpa) | 萃取温度(℃) | 夹带剂 | 空列 | 得率% | 5%显著水平 |
08 | 25 | 48 | 正己烷 | 3 | 13.5193 | b |
09 | 30 | 50 | 石油醚 | 1 | 15.1596 | c |
最佳参数 | 20 | 48 | 正己烷 | 15.266 |
Claims (4)
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CN2009102182412A CN101759548B (zh) | 2009-11-24 | 2009-11-24 | 一种使用超临界co2萃取大黄中大黄素的制备工艺 |
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CN2009102182412A CN101759548B (zh) | 2009-11-24 | 2009-11-24 | 一种使用超临界co2萃取大黄中大黄素的制备工艺 |
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Publication Number | Publication Date |
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CN101759548A true CN101759548A (zh) | 2010-06-30 |
CN101759548B CN101759548B (zh) | 2012-12-05 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104817445A (zh) * | 2015-04-16 | 2015-08-05 | 聊城大学 | 一种从虎杖中分离纯化大黄素甲醚和大黄素的方法 |
CN105906493A (zh) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | 一种大黄素的提取工艺 |
-
2009
- 2009-11-24 CN CN2009102182412A patent/CN101759548B/zh active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104817445A (zh) * | 2015-04-16 | 2015-08-05 | 聊城大学 | 一种从虎杖中分离纯化大黄素甲醚和大黄素的方法 |
CN105906493A (zh) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | 一种大黄素的提取工艺 |
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Address after: 650503 Kunming new town high tech industrial base, Hing Street, No. 39, Yunnan Co-patentee after: Luo Shi Patentee after: YUNNAN LEIYUNSHANG LIXIANG PHARMACEUTICAL CO.,LTD. Address before: 650106 Kunming national hi tech Industrial Development Zone, Yunnan Province, Jin Road, No. 139 Co-patentee before: Luo Shi Patentee before: YUNNAN LIXIANG PHARMACEUTICAL Co.,Ltd. |
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