CN101720332B - 生产促卵泡激素的细胞克隆 - Google Patents

生产促卵泡激素的细胞克隆 Download PDF

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Publication number
CN101720332B
CN101720332B CN200880022358.7A CN200880022358A CN101720332B CN 101720332 B CN101720332 B CN 101720332B CN 200880022358 A CN200880022358 A CN 200880022358A CN 101720332 B CN101720332 B CN 101720332B
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CN
China
Prior art keywords
nucleic acid
acid sequence
seq
stimulating hormone
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200880022358.7A
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English (en)
Chinese (zh)
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CN101720332A (zh
Inventor
S·阿诺德
N·耶利内克
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Ty Hamax Headquarters Uk Ltd
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Ratiopharm GmbH
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Publication of CN101720332A publication Critical patent/CN101720332A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN200880022358.7A 2007-06-28 2008-06-27 生产促卵泡激素的细胞克隆 Expired - Fee Related CN101720332B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07111257 2007-06-28
EP07111257.7 2007-06-28
PCT/EP2008/058274 WO2009000913A1 (en) 2007-06-28 2008-06-27 Fsh producing cell clone

Publications (2)

Publication Number Publication Date
CN101720332A CN101720332A (zh) 2010-06-02
CN101720332B true CN101720332B (zh) 2014-08-13

Family

ID=39745099

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880022358.7A Expired - Fee Related CN101720332B (zh) 2007-06-28 2008-06-27 生产促卵泡激素的细胞克隆

Country Status (23)

Country Link
US (1) US8318457B2 (enExample)
EP (2) EP2170942B1 (enExample)
JP (1) JP5570980B2 (enExample)
KR (1) KR101522217B1 (enExample)
CN (1) CN101720332B (enExample)
AU (1) AU2008267138B9 (enExample)
BR (1) BRPI0813913B1 (enExample)
CA (1) CA2690844C (enExample)
CY (1) CY1114463T1 (enExample)
DK (1) DK2170942T3 (enExample)
EA (1) EA022993B1 (enExample)
ES (1) ES2432183T3 (enExample)
HR (1) HRP20130921T1 (enExample)
IL (1) IL202280A (enExample)
MX (1) MX2010000385A (enExample)
NZ (1) NZ581702A (enExample)
PL (1) PL2170942T3 (enExample)
PT (1) PT2170942E (enExample)
RS (1) RS52976B (enExample)
SI (1) SI2170942T1 (enExample)
UA (1) UA103598C2 (enExample)
WO (1) WO2009000913A1 (enExample)
ZA (1) ZA200908168B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101573773B1 (ko) 2008-02-08 2015-12-02 바이오제너릭스 게엠베하 Ｆｓｈ의 액체 포뮬레이션
CA2755927A1 (en) * 2009-04-01 2010-10-14 Biogenerix Ag Method for purifying recombinant fsh
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN105462909B (zh) * 2015-12-31 2019-09-27 哈药集团技术中心 一种高效表达人促卵泡激素的cho细胞的培养方法
CN107460206B (zh) * 2017-09-11 2020-05-01 深圳市深研生物科技有限公司 人fsh的重组表达载体、重组细胞株及重组人fsh的制备方法
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
CN110812366B (zh) * 2019-11-18 2023-11-17 珠海丽凡达生物技术有限公司 一种可用于激素补充的mRNA药物及其制备方法
CN120519466A (zh) * 2025-07-23 2025-08-22 苏州晟济药业有限公司 卵泡刺激素表达系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0404546A2 (en) * 1989-06-20 1990-12-27 Genzyme Corporation Heteropolymeric protein production
WO2001058493A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
WO2005030969A1 (en) * 2003-10-02 2005-04-07 Progen Co., Ltd. Method for mass production of human follicle stimulating hormone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
CA2223125A1 (en) 1995-02-17 1996-08-22 Stichting Instituut Voor Dierhouderij En Diergezondheid Production of biologically active recombinant bovine follicle stimulating hormone (recbfsh) in the baculovirus expression system
TW518235B (en) 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
PL346127A1 (en) 1998-07-23 2002-01-28 Lilly Co Eli Fsh and fsh variant formulations, products and methods
EP1169349B1 (en) 1999-04-16 2007-03-28 Instituto Massone S.A. Process for preparing gonadotropin compositions
US20020127652A1 (en) 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
KR20050083691A (ko) * 2002-09-13 2005-08-26 더 유니버시티 오브 퀸스랜드 코돈 번역 효율에 기초한 유전자 발현 시스템
ES2333128T3 (es) 2003-12-22 2010-02-17 Ares Trading S.A. Metodo para purificar fsh.
SI1809663T1 (sl) 2004-11-09 2009-02-28 Ares Trading Sa Postopek za äśiĺ äśenje fsh
TWI369401B (en) * 2005-07-05 2012-08-01 Ares Trading Sa Serum-free culture medium for the production of recombinant gonadotropins
US20070281883A1 (en) 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0404546A2 (en) * 1989-06-20 1990-12-27 Genzyme Corporation Heteropolymeric protein production
WO2001058493A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
WO2005030969A1 (en) * 2003-10-02 2005-04-07 Progen Co., Ltd. Method for mass production of human follicle stimulating hormone

Also Published As

Publication number Publication date
PT2170942E (pt) 2013-10-22
RS52976B (sr) 2014-02-28
EP2492280A1 (en) 2012-08-29
BRPI0813913A8 (pt) 2018-02-14
CA2690844A1 (en) 2008-12-31
WO2009000913A1 (en) 2008-12-31
JP2010531148A (ja) 2010-09-24
US20120034655A1 (en) 2012-02-09
CA2690844C (en) 2016-05-17
UA103598C2 (uk) 2013-11-11
BRPI0813913A2 (pt) 2014-12-30
AU2008267138B2 (en) 2014-01-16
EP2170942A1 (en) 2010-04-07
AU2008267138A1 (en) 2008-12-31
IL202280A0 (en) 2010-06-16
ZA200908168B (en) 2010-07-28
BRPI0813913B1 (pt) 2022-04-19
EA022993B1 (ru) 2016-04-29
US8318457B2 (en) 2012-11-27
KR101522217B1 (ko) 2015-05-21
MX2010000385A (es) 2010-03-29
HK1140782A1 (en) 2010-10-22
DK2170942T3 (da) 2013-11-04
AU2008267138B9 (en) 2014-06-05
SI2170942T1 (sl) 2013-12-31
PL2170942T3 (pl) 2013-12-31
CN101720332A (zh) 2010-06-02
IL202280A (en) 2014-12-31
NZ581702A (en) 2011-10-28
CY1114463T1 (el) 2016-10-05
KR20100051632A (ko) 2010-05-17
EP2170942B1 (en) 2013-07-31
HRP20130921T1 (hr) 2013-11-08
EA201070071A1 (ru) 2010-10-29
JP5570980B2 (ja) 2014-08-13
ES2432183T3 (es) 2013-12-02

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Owner name: RATIOPHARM GMBH

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Effective date: 20140717

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TA01 Transfer of patent application right

Effective date of registration: 20140717

Address after: Ulm

Applicant after: RATIOPHARM GmbH

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Applicant before: Biogenerix AG

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Applicant after: BIOGENERIX AG

Address before: Mannheim

Applicant before: Biogenerix AG

C14 Grant of patent or utility model
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Effective date of registration: 20180611

Address after: London, England

Patentee after: Ty Hamax Headquarters UK Ltd.

Address before: Ulm

Patentee before: Ratiopharm GmbH

TR01 Transfer of patent right
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140813