CN101688239A

CN101688239A - 结肠癌的早期检测和预后

Info

Publication number: CN101688239A
Application number: CN200880010320A
Authority: CN
Inventors: S·B·拜林; K·E·舒贝尔; W·V·克里金格
Original assignee: OncoMethylome Sciences SA; Johns Hopkins University
Current assignee: OncoMethylome Sciences SA; Johns Hopkins University
Priority date: 2007-02-12
Filing date: 2008-02-12
Publication date: 2010-03-31
Also published as: WO2008100913A2; EP2118319A2; US20080221056A1; CA2676227A1; WO2008100913A3; JP2010517582A; EP2118319A4

Abstract

我们已经开发了全转录物组方法来鉴定在结肠直肠癌(CRC)中受到启动子CpG岛过度甲基化和转录沉默影响的基因。通过在一组原发性人类CRC样品中筛查细胞系和确认肿瘤特异性过度甲基化，我们估计在个体肿瘤中所有已知基因的几乎5％可能被启动子甲基化。当直接与基因突变比较时，我们在个体肿瘤中发现数量大得多的基因被过度甲基化，和在包含遗传或者外遗传变化的个体基因内高得得多的过度甲基化频率。因此，为了列举人类癌症基因组中的全变化谱，和有助于对肿瘤进行最有效的分组从而鉴定癌症生物标记并调整治疗方法，应该进行遗传和外遗传两种筛查。我们鉴定的基因可以用于诊断性地检测癌症、初癌和发展癌的可能性等等。

Description

结肠癌的早期检测和预后

[01]本发明是使用来自国家环境卫生科学研究所(National Institute ofEnvironmental Health Sciences)的补助金第ES11858号和来自国家癌症研究所(National Cancer Institute)的补助金第CA043318号的美国政府资金完成的。美国政府根据这些补助金的条款保留本发明的某些权利。

发明技术领域

[02]本发明涉及癌症诊断和治疗的领域。特别地，它涉及在结肠癌和初癌(pre-cancer)中特定基因的异常甲基化模式(形式，pattern)。

发明背景

DNA甲基化和它在癌发生中的作用

[03]制造所有活生物的细胞的信息包含在它们的DNA中。DNA是由四个碱基的独特序列组成，四个碱基为：腺嘌呤(A)、鸟嘌呤(G)、胸腺嘧啶(T)和胞嘧啶(C)。在形成DNA双螺旋的两条链上，这些碱基A与T和G与C配对。这些碱基对的链存储制造分组成被称为基因的区域的具体分子的信息。在每一个细胞里面，具有控制什么基因被开启或表达的程序，从而确定每个细胞的独特功能。这些控制机制之一是通过将甲基加到胞嘧啶(C)上而提供。甲基标记的C可以写成mC。

[04]DNA甲基化在确定是否一些基因被表达或者不被表达中起到重要的作用。通过关闭不需要的基因，DNA甲基化是生物体正常发育和发挥功能的必不可少的控制机制。可选地，异常的DNA甲基化是引起随着老化和多种癌症的发生而观察到的变化的机制之一。

[05]癌症在过去与在DNA内由染色体突变引起的基因变化联系起来。突变——遗传性的或获得性的——可以导致对于维持健康状态至关重要的基因表达的丧失。现在证据支持，相当大数量的癌症由不适宜的DNA甲基化，频繁接近的DNA突变所引起。在许多情况下，DNA的过度甲基化不正确地关闭至关重要的基因例如肿瘤抑制基因或者DNA修复基因，从而使得癌症能够发生和进展。这种控制基因表达的非突变过程被描述为外因遗传学(或表观遗传学，epigenetics)。

[06]DNA甲基化是通过称为甲基转移酶的酶来进行的DNA化学修饰，在其中甲基基团(m)被加到DNA的某些胞嘧啶(C)。这种非突变的(外遗传的)过程(mC)是基因表达调控中的关键因素，参见J.G.Herman，Seminars in CancerBiology，9：359-67，1999。

[07]虽然基因甲基化的现象已经引起癌症研究者的注意有一段时间，但是它在人的癌症发展中的真正作用刚被认识到。在正常的细胞中，甲基化主要发生在具有很少CG碱基重复的DNA区域中，而CpG岛，具有长CG碱基重复的DNA区域，仍然保持非(未)甲基化。控制蛋白表达的基因启动子区域通常是富含CpG岛的。在启动子区域中这些正常的非甲基化CpG岛的异常甲基化导致在人癌症中某些肿瘤抑制基因表达的转录失活或者沉默。

[08]在肿瘤细胞中的过度甲基化的基因对于肿瘤来源的组织是非常特异的。所有类型癌症的分子特征可以用于改进癌症的检测、癌症风险的评估和对治疗的反应。启动子过度甲基化事件为这些目的提供了一些最有希望的标记。

启动子基因过度甲基化：有希望的肿瘤标记

[09]关于特定启动子基因的过度甲基化的信息可以有益于各种癌症的诊断、预后和治疗。特定基因启动子区域的甲基化可以在早期和经常在癌发生中出现，使得这些标记成为癌症诊断的理想靶标。

[10]甲基化模式是肿瘤特异的。阳性信号总是在基因的相同位置被发现。实时PCR为基础的方法是高度灵敏的、定量的和适合于临床使用。DNA是稳定的和发现在容易获得的流体(例如血清、痰、粪便、血液和尿)和石蜡包埋组织中是完整的。一系列有关的基因标记可以覆盖大多数人类癌症。

诊断

[11]改善在癌症患者中的临床结果的关键是在癌症的最早阶段的诊断，在此期间癌症仍然是局部的和容易治疗的。上文提到的特征通过在分子基础上鉴定较高风险患者提供了更准确地筛查和监测计划的手段。它也为对患者进行更明确的随访(follow up)提供了理由，所述患者具有与恶性病相关的分子特征，但是还没有与恶性病相关的所有病理或者临床特征。

[12]在目前，结肠直肠癌的早期检测是通过以下几种方法来进行的：(1)“粪便潜血试验”(FOBT)，它具有非常低的灵敏度和特异性，(2)乙状结肠镜检查和/或结肠镜检查，它具有侵入性并且是昂贵的(以及供应有限)，(3)在双重对比钡餐灌肠后的X射线检查，其仅允许检查相当大的息肉，或者CT-结肠镜检查(也被称为虚拟结肠镜检查)，它仍然是实验性的，和(4)称为PreGen-Plus的基因突变分析试验(Exact Sciences；LabCorp)，它是昂贵的且灵敏度有限。

预测治疗反应

[13]关于癌症如何通过分子事件发展的信息将使得临床医生能够更准确地预测这种癌症对特定的化疗剂可能怎样反应。这样，根据肿瘤的化学敏感性的知识可以理性地设计治疗方案(regimen)。研究已经显示，在神经胶质瘤患者中的MGMT启动子的过度甲基化表明对治疗的良好反应、更大的总生存率和进展需要更长时间。

[14]现在充分确立了，在人的癌症中正确基因功能的丧失可以通过遗传和外遗传机制来发生(1、2)。在人的肿瘤样品中突变基因的数量正在被阐明。最近，

等(3)测序了在结肠直肠癌(CRC)和乳腺癌中的13,023个基因，发现每个肿瘤平均11个突变，这提示了相对少量的遗传事件可能足够促使肿瘤发生。相比之下，外遗传改变的整个图谱没有被充分描述。最详细说明的癌基因外遗传学改变涉及在与受影响基因的转录失活相关的启动子区域中，成簇的CpG二核苷酸或者CpG岛的DNA过度甲基化。这些启动子接近所有基因的几乎一半而定位(4)，并且认为这些启动子在正常的体细胞组织中基本上保持无甲基化。在任何特定的肿瘤中的这种外遗传损害的精确数量不是准确已知的，虽然不断增加数量的随机筛查方法正在鉴定不断增加数量的候选基因(5-12)，但是这些方法中没有一个方法有效覆盖全基因组。考虑到在基因组中存在大量潜在目标启动子，我们假定还有很多过度甲基化的基因等待发现(13)。

[15]在本领域中有对改善患者护理管理的针对癌症的新的诊断和预后标记以及治疗靶标的持续的需求。

发明概述

[16]依照本发明的一方面，提供鉴定结肠直肠癌或者它的前体、或结肠直肠癌倾向的方法。在含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中检测外遗传沉默。外遗传沉默是选自以下的至少一个基因：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。当外遗传沉默被检测到时，试样被鉴定为含有细胞，所述细胞是瘤性的(增殖性的)、瘤的前体、或易于形成瘤，或者鉴定为含有来自细胞的核酸，所述细胞是瘤性的、瘤的前体、或易于形成瘤。

[17]依照本发明的另一个方面，提供了减少或者抑制细胞瘤性(增殖性)生长的方法，所述细胞显示了与癌症相关的至少一种基因的外遗传沉默的转录。外遗传沉默的基因在细胞中被确定。所述基因选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。通过将细胞与一种或者多种试剂接触恢复外遗传沉默基因编码多肽在细胞中的表达，所述试剂选自：CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂。不受调节的细胞生长因而被减少或者抑制。

[18]本发明的另一方面是减少或抑制细胞的瘤性生长，该细胞显示了与癌症相关的至少一种基因的外遗传沉默转录。外遗传沉默基因在细胞中被确定。所述基因选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。编码多肽的多核苷酸被引入到细胞中。多肽被所述基因表达。多肽在细胞中被表达，因而恢复多肽在细胞中的表达。

[19]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有选自以下的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。一种或者多种选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂的试剂以足够量给予患者，以恢复在患者的癌细胞中外遗传沉默基因的表达。

[20]本发明的还另一方面是治疗癌症患者的方法。患者的癌细胞被确定具有选自在以下显示的外遗传沉默的基因：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF 182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。编码多肽的多核苷酸被给予患者。多肽由外遗传沉默的基因编码。多肽在患者的肿瘤中进行表达，从而恢复多肽在癌症中的表达。

[21]依照本发明的另一方面，提供了选择治疗癌症患者的治疗策略的方法。基因被鉴定，该基因在患者癌细胞中的表达通过CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂或者组蛋白脱乙酰酶(HDAC)抑制剂再激活。基因选自BOLL、CABYR、EFEMP1、FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。为癌症患者选择治疗剂，该治疗剂增加基因的表达，用于治疗所述癌症患者。

[22]本发明的另一个实施方式是评估试样中甲基化的试剂盒。试剂盒包括至少以下试剂：(a)修饰甲基化的胞嘧啶残基、但不修饰非甲基化的胞嘧啶残基的试剂，或者(b)修饰非甲基化的胞嘧啶残基、但不修饰甲基化的胞嘧啶残基的试剂；和一对寡核苷酸引物，其在扩增条件下与大约1kb的所述基因转录起始位点内的基因区域特异性杂交，所述基因选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655中显示的基因。

附图简述和表格

[23]图1A-1E.在HCT116CRC细胞中鉴定人癌细胞的过度甲基化组(hypermethylome)的方法。(图1A)来自标示细胞系的RNA被分离、标记、杂交、扫描，以及荧光点强度通过减去背景来归一化和使用Agilent Technologies 44K人微阵列进行黄土转变(Loess transformation)。在我们的研究中比较了亲本野生型HCT116细胞(WT)和DNA甲基转移酶1(DNMT1-/-)或者3b(DNMT3b-/-)的同基因敲除对应物。DKO细胞对于DNMT1和DNMT3b是双重缺陷的。(图1B)在具有各种DNA甲基转移酶的遗传中断的HCT116细胞中，基因表达变化。三维散布图以对数单位指出了在HCT116细胞中的基因表达水平，所述细胞具有DNMTs 1(X轴)、3b(Z轴)和两种DNMT(DKO；Y轴)的遗传中断。对于DKO细胞中具有大于4倍表达变化的那些基因，单个基因表达的变化为黑色，对三个实验的平均值(红色点)或者来自单个实验(蓝色点)。(图1C)HCT116细胞用300nM曲古柳菌素A(TSA)处理18小时或者用5μM的5-脱氧氮杂胞苷(DAC)处理96小时，如前所述处理。(图1D)对于用TSA(X轴)或者DAC(Y轴)处理的HCT116细胞的基因表达变化通过倍数变化来绘图。黄色点指出来自DKO细胞具有2倍和2倍以上变化的基因。当与在DKO细胞中看到的基因表达增加比较时(在DKO细胞中大于2倍现在变成了在DAC处理的细胞中大于1.3倍)，注意到敏感性的丧失。绿色点指出了随机选择的基因，其已被证实在野生型细胞中具有完整的启动子甲基化、在DKO细胞中和在AZA处理后的重新表达，而红色点指出了经鉴定为假阳性的选择基因(参见确认结果的图5(S2))。蓝色点指出了11种引导基因的位置——这11种引导基因在先前表现为过度甲基化的和在这个研究中使用的HCT 116细胞中为完全沉默的(参见图4(S1)的描述)。包括11种引导基因中的5种的独特组的基因显示了在用DAC处理后大于2倍的增加、而用TSA处理后没有增加。这些基因形成了在文本中讨论的候选过度甲基化基因的顶部列。(图1E)通过树状图分析来鉴定全转录物组表达型的关联性。DNMT1和3b、DKO的个体单个遗传中断以及DAC处理和TSA处理各自形成三个不同类别的基因表达变化。

[24]图2A-2C.在不同的人CRC细胞系中表征人癌细胞过度甲基化组。(图2.A)用TSA(X轴)或者DAC(Y轴)处理的指示细胞的基因表达变化通过倍数变化来绘图，单个基因用黑色来显示。(图2B)DNA过度甲基化组的确认。由用DAC或者TSA处理细胞来限定的过度甲基化基因的特有峰(spike)由2个具有不同特征的层组成。上层基因鉴定为这样的区域，在该区域中，基因表达不随着TSA增加(＜1.4倍)，并且在野生型细胞中没有显示出可检测的表达，但是用DAC处理后有大于2倍的增加。下层的基因被鉴定为一组基因，其表达变化与在上层中的相同、但是用DAC处理增加1.4倍至2倍之间。通过RT-PCR和MSP确认基因表达，表明在HCT116细胞中上层基因86％的确认频率，包括在DKO细胞中增加2倍以上的基因。在HCT116细胞中下层基因被确认在49％的频率，和在SW480上层中具有65％的频率。(图2C)在CRC细胞系中共有的候选过度甲基化基因。我们鉴定了在所有6个细胞系中具有落入上层或者下层类别标准的表达变化的总共5,906个基因。指出了在2、3、4、5或者6细胞系当中基因表达变化的重叠；这些的范围从2个细胞系中共有的1414个基因，到6个细胞系中共有的78个基因。

[25]图3A-3E.在人肿瘤样品中过度甲基化和基因突变频率的比较。(图3A)在人组织样品中验证的过度甲基化组基因的甲基化分析。来自验证的基因清单的二十种基因从HCT116上层(BOLL、DDX43、DKK3、FOXL2、HoxD1、JPH3、Nef、神经化的、PPP1R14a、RAB32、STK31、TLR2)、HCT116下层(SalL4、TP53AP1)或者SW480上层(ZFP42)中随机地选择，并且分析在CRC细胞系(白色柱)、正常结肠(红色柱)或者原发性肿瘤(绿色柱)中的甲基化。甲基化的百分比在Y轴上示出，和缩写的基因名称在X轴上。我们测试了至少6种不同的细胞系、来自非癌症患者的16到40个结肠样品和18到61个之间的原发性CRC样品的每种基因。(图3B)CAN基因的甲基化分析。56种基因鉴定为重叠了过度甲基化组和CAN基因列单，包括含有CpG岛的45种基因。来自这个列单的、在细胞系中具有甲基化的选择的基因(26种基因)，被在分析在正常结肠(图3B)和原发性CRC(图3C)中的甲基化。这些基因的甲基化频率以百分比显示。(图3D)重叠了CAN和过度甲基化组基因列单的13种基因的甲基化和突变之间的关系。(图3E)在人癌症中基因失活机制的模型。

[26]图4A-D.(S1).在这个研究中使用的引导基因。(图4A)先前显示在HCT116细胞中被过度甲基化和完全沉默的11种引导基因的基因名称、AgilentTechnologies探针名称、Genbank登录号和参考。(图4B)蓝色点和基因名称指出在TSA(X轴)对DAC(Y轴)基因表达变化图中或者在(图4C)DKO(X轴)对单个敲除(Y轴)基因表达变化的图中的11种引导基因的位置，以对数表示。用绿色圈出的11种引导基因中的5种在用AZA处理后显示了大于2倍的增加，但是用TSA处理后没有增加，这些同样的基因并且在DKO细胞中(绿色圆圈)中有大于3倍的增加。(图4D)在DKO和DAC图中引导基因的直接比较。由绿色圆圈示出的不同组的5种引导基因限定了如在本文中所讨论的候选过度甲基化基因的上层，5种引导基因在DKO细胞中显示出大于3倍的表达变化和在DAC处理的细胞中显示出大于2倍的表达变化。在用DAC处理后增加1.3倍的另外三种基因和未增加的3种基因允许基因表达的下层的标准建立起来，如在文中所述。

[27]图5.(S2).在HCT116细胞中35种上层基因的基因表达和甲基化确证。HCT116候选过度甲基化基因的清单，其被选择用于表达(通过HCT116和DKO细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO细胞的MSP)状况的确证。基因描述在图的左边示出，基因名称在PCR结果后示出。水(RT-PCR和MSP)、在体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB)用为每一单个基因的对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴定那些没有验证阵列结果的基因。

[28]图6.(S3.)35种HCT116候选下层基因的清单，其被选择用于确证表达(通过HCT116和DKO细胞的RT-PCR)和启动子甲基化(通过HCT116和DKO细胞的MSP)状况。在图的左边示出了基因名称，基因名称在PCR结果后面显示。水(RT-PCR和MSP)、体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB)用作每一单个基因的对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴定那些没有验证阵列结果的基因，如文中所论述地。

[29]图7.(S4.)48种SW480候选上层基因的清单，其被选择用于确证表达(通过SW480和DAC处理的SW480细胞的RT-PCR)和启动子甲基化(通过SW480和DAC处理的SW480细胞的RT-PCR)状况。在图的左边指出了基因名称，基因名称在PCR结果后面显示。水(RT-PCR)、体外甲基化DNA(MSP的IVD)和肌动蛋白B(ACTB)用作每一单个基因的对照；显示了代表性的样品。绿色箭头鉴定验证了阵列结果的基因，红色箭头鉴定那些没有验证阵列结果的基因，如文中所论述地。

[30]图8.(表S1.)过度甲基化组大小的定量估计。细胞系和层在左边指出，和每层中鉴定的基因表达变化的数量也被示出。关于每层候选过度甲基化基因库的大小的计算通过每层鉴定的基因表达变化乘以0.86(HCT116的上层)、0.65(SW480、CaCO2、HT29、COLO320和RKO的上层)或者0.49(HCT116、SW480、CaCO2、HT29、COLO320和RKO下层)来进行。这些分数代表了实验所确定的确认频率，如在本文所描述的。HCT116过度甲基化组大小的估计源于如下：532的86％＝457上层基因加上1190的49％＝583下层基因；457+583＝1040。依照如下计算，SW480过度甲基化组估计在579个基因：318上层的66％＝207和759下层的49％＝372；207+372＝579。过度甲基化组基因清单和在乳腺癌或者结肠癌中突变的基因之间的重叠在右边显示。

[31]图9.(表1)关于在序列表中的序列的信息。基因编号：基因流水号。基因名称：在专利中使用的基因名称。基因ID：NCBI系统的基因ID。与基因ID相关的转录物ID：来自ENSEMBL注释系统的所有转录物IDs，与具有相同TSS[转录起始位置；注意，基因ID可以具有多个TSS，因而多转录物IDs通过它们的TSS来分组]的特定基因ID相关。SEQ ID NO：1-125：基因组序列前后序列(从转录物TSS的5′1000bp，到转录物TSS 3′的200bp)；如在NCBI build 36中发现的基因组DNA序列。SEQ ID NO：126-250：亚硫酸氢盐转化形式的序列，假设所有CpG二核苷酸的全甲基化存在。

[32]图10-截止比(ratio cut-off)20的散射图BNIP3。

[33]图11-截止比20的散射图FOXE1。

[34]图12-截止比100的散射图SYNE1。

[35]图13-截止比300的散射图SOX17。

[36]图14-截止比20的散射图JAM3。

[37]图15-截止比150的散射图MMP2。说明：这个标记在76个对照和90个病例中进行了测试。

[38]图16-截止比150的散射图GPNMB。说明：这个标记在76个对照和90个病例中进行了测试。

发明详述

[39]我们描述了人类全转录物组微阵列筛查来鉴定在人类CRC中被启动子过度甲基化所沉默的基因。这种方法容易以高的证实效率在单个肿瘤中鉴定候选癌基因。通过比较一系列候选过度甲基化基因与最近在CRC(3)中鉴定的突变基因，我们建立了改变的肿瘤基因组和基因过度甲基化组之间关键的关系。我们的研究提供了理解表观和遗传的改变如何促使人肿瘤发生的平台。

[40]我们描述了基因表达方法，对于可获得代表性细胞培养系的任何人类癌症类型，该方法具有确定大部分癌基因启动子CpG岛DNA过度甲基化组的能力。对这些基因的研究将有助于理解促使肿瘤发生的分子通路、提供有用的新DNA过度甲基化生物标记来监测癌症风险评估、早期诊断和预后，并且允许在癌症预防和/或治疗策略期间更好地监测基因再表达(13，22)。

[41]通过由我们方法发现的过度甲基化组基因与由基因组广泛测序策略(genome wide sequencing strategy)鉴定的突变基因的直接比较，我们证明了在任何特定的肿瘤中存在比遗传变化基因多许多的外遗传(表观)变化基因。这个事实的重要性在我们的发现中显现：对于受两种机制影响的新发现的基因，在结肠癌中任何特定基因的过度甲基化的发生率显得比突变高得多。因此，在特定的癌类型中，由于未能筛查遗传和表观遗传异常，本领域技术人员可能明显地低估全范围的基因改变和相关的细胞通路异常。数据也指出，比单独遗传分析所预测的，评估基因功能丧失的两种机制对于通路中断在个体结肠肿瘤中显示出更多的共性(sharing)。我们的发现强调，依照在关键通路中的分子改变对肿瘤分类的最佳方法应该依赖于确定遗传和表观基因变化。因此，我们的发现应该促进在癌症中绘制异常基因变化的任何基因广泛策略，从而考虑：应该检查突变基因的启动子DNA过度甲基化和DNA过度甲基化基因应该放在进行测序以发现突变的优先位置。

[42]使用这种技术，我们已经发现了一组基因，它们的转录在癌、癌前体和初癌中被外遗传沉默。这些基因包括：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化的(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。检测到这些基因的至少1、2、3、4、5、6、7、8、9或10个的外遗传沉默可以用作癌或者初癌或者发展癌的风险的指示。

[43]基因的外遗传沉默可以通过在本领域中任何已知的方法确定。一种方法是确定在正常细胞或者其它对照细胞中表达的基因在肿瘤细胞中较少表达或者不表达。然而这种方法本身不能够指出沉默是外遗传性的，因为沉默的机制可能是遗传的，例如通过体细胞突变。一种确定沉默是外遗传的方法是用试剂如DAC(5′-去氮杂胞苷)(5′-deazacytidine)或者用改变细胞DNA的组蛋白乙酰化状况的试剂来处理，或者影响在细胞中的外遗传机制的任何其它处理，并且观察沉默被逆转，也就是基因的表达被再激活或者恢复。另一种确定外遗传沉默的方法是确定在沉默基因中甲基化的CpG二核苷酸基序的存在。典型地，这些存在于转录起始位置的附近，例如在大约1kbp之内、大约在750bp之内或者大约在500bp之内。一旦基因被鉴定为在肿瘤细胞中外遗传沉默的靶标，减少表达的确定可以用作外遗传沉默的指示物。

[44]基因的表达可以使用本领域已知的任何方法来评估。典型地，表达可以在试样和对照样品中评估和比较，对照样品是正常的、非恶性的细胞。试样可以含有癌细胞或者初癌细胞或者来自它们的核酸。例如，样品可以含有结肠腺瘤细胞、结肠晚期腺瘤细胞或者结肠癌细胞。mRNA(核酸)或者蛋白可以被测量。可以使用应用与核酸探针杂交的方法测量具体的mRNAs。这些方法包括使用核酸探针阵列(微阵列技术)、原位杂交和使用Northern印迹。信使RNA也可以使用扩增技术如RT-PCR来评估。基因组技术中的进步现在允许同时分析数千个基因，虽然许多是根据特定探针-靶标杂交的相同概念。测序为基础的方法是可选的；这些方法开始时使用表达的序列标签(EST)，并且现在包括基于短标签的方法，例如基因表达系列分析(SAGE)和大规模平行特征测序(MPSS)。差别显示技术提供了分析基因表达的另外方法；这类技术基于由限制性消化产生的cDNA片段的随机扩增，以及在两种组织之间不同的带鉴定感兴趣的cDNA。特定的蛋白可以使用任何常规方法来评估，包括但不限于免疫测定和免疫细胞化学术。大部分这些方法将使用对特定的蛋白或者蛋白片段特异的抗体。本发明的标记的mRNA(cDNA)和蛋白的序列在本领域是已知的和可以公开得到的。

[45]甲基化敏感的限制性内切核酸酶可以用于检测甲基化的CpG二核苷酸基序。这种核酸内切酶可以相对于非甲基化识别位点而优先剪切甲基化识别位点，或者相对于甲基化识别位点而优先剪切非甲基化的识别位点。前者的例子是AceIII、Ban I、BstN I、Msp I和Xma I。后者的例子是Ace II、Ava I、BssH II、BstU I、Hpa II和Not I。可选地，可以使用选择性地修饰甲基化的或者非甲基化形式的CpG二核苷酸基序的化学试剂。

[46]修饰产物可以直接检测或者在产生容易辨别的产物的进一步反应之后进行检测。检测改变的大小和/或电荷的方法可以用于检测修饰的产物，方法包括但不限于电泳、色谱和质谱。这种选择性修饰的化学试剂例子包括肼和亚硫酸氢盐离子。肼修饰的DNA可以使用哌啶处理来剪切它。亚硫酸氢盐离子处理的DNA可以用碱来处理。其它依赖特定序列的方法也可以使用，包括但不限于杂交、扩增、测序和连接酶链反应。如果期望，可以使用这些技术的组合。

[47]电泳的原理是通过它们的大小和电荷来分离核酸。存在用于检测甲基化的许多测定方法，并且大部分依赖于确定特定核酸产物的有无。在实验室中为了此目的经常使用凝胶电泳。

[48]本领域技术人员可以使用MALDI质谱结合甲基化检测分析来观察核酸产物的大小。质谱的原理是对核酸进行离子化和依照它们的质荷比来分离它们。类似于电泳，本领域技术人员可以使用质谱来检测在实验中产生的特定核酸以确定甲基化。参见Tost，J.等，Analysis and accurate quantification of CpG methylation byMALDI mass spectrometry.Nuc Acid Res，2003，31，9。

[49]一种形式的色谱，高效液相色谱用于根据被分析物质与色谱柱之间的各种化学相互作用来分离混合物的成分。DNA首先用亚硫酸氢钠来处理，其将未甲基化的胞嘧啶转化成为尿嘧啶，而甲基化的胞嘧啶残基保持不受影响。本领域技术人员可以经过PCR扩增含有潜在甲基化位置的区域和通过变性高效液相色谱(DHPLC)来分离产物。DHPLC具有区别甲基化的(含有胞嘧啶)和没有甲基化的(含有尿嘧啶)DNA序列的分辨能力。参见Deng，D.等，Simultaneous detectionof CpG methylation and single nucleotide polymorphism by denaturing highperformance liquid chromatography.2002Nuc Acid Res，30，3。

[50]杂交是根据两条互补核酸链的退火形成双链分子来检测特定核酸序列的技术。杂交使用的一个例子是用于确定DNA甲基化状况的微阵列分析。在亚硫酸氢钠处理DNA之后——其将未甲基化的胞嘧啶转变成为尿嘧啶，而甲基化的胞嘧啶残基保持不受影响，与潜在甲基化位点互补的寡核苷酸可以与亚硫酸氢盐处理的DNA杂交。寡核苷酸被设计成与含有尿嘧啶的序列或者含有胞嘧啶的序列互补，其分别代表了未甲基化的和甲基化的DNA。以计算机为基础的微阵列技术可以确定哪个寡核苷酸与DNA序列杂交，并且本领域技术人员可以推断DNA的甲基化状况。

[51]确定在亚硫酸氢钠处理后结果的另外的方法将会是对DNA测序，以直接观察任何亚硫酸盐的修饰。焦磷酸测序(Pyrosequecing)技术是通过合成测序的实时方法。它基于焦磷酸盐(PPi)的间接生物光度计分析(bioluminometric assay)，焦磷酸盐(PPi)是当DNA链延伸时从每个脱氧核苷酸(dNTP)中释放。这种方法在核酸外切酶缺陷的Klenow DNA聚合酶存在的情况下呈现带有dNTP的DNA模板-引物复合体。四种核苷酸以预先确定的顺序依次加到反应混合物中。如果核苷酸与模板碱基互补并因而被加入，那么PPi被释放。PPi和其它试剂用作在荧光素酶反应中的底物，荧光素酶反应产生通过光度计或者电荷耦合装置检测的可见光。产生的光与加到DNA引物的核苷酸数量成比例，并且产生以热解图的形式存在的指示核苷酸数量和类型的峰。焦磷酸测序可以利用在DNA的亚硫酸氢钠转化后产生的序列差异。

[52]各种扩增技术可以在产生可辨别产物的反应中使用。这些技术的一些利用PCR。其它合适的扩增方法包括连接酶链反应(LCR)(Barringer等，1990)、转录扩增(Kwoh等.1989；WO88/10315)、目标多核苷酸序列的选择性扩增(美国专利6,410,276)、共有序列引发的聚合酶链反应(美国专利4,437,975)、随机引发的聚合酶链反应(WO90/06995)、核酸序列依赖性扩增(NASBA)(美国专利5,409,818；5,554,517；6,063,603)、切口置换扩增(nick displacement amplification)(WO2004/067726)。

[53]反映原始基因组DNA中CpG二核苷酸处的甲基化状况的序列变化提供了PCR引物设计的两种方法。在第一种方法中，引物自身不“覆盖”任何潜在的DNA甲基化位点或者不与任何潜在的DNA甲基化位点杂交；在不同甲基化的位点处的序列变化位于两引物之间。这种引物被用在亚硫酸氢盐基因组测序、COBRA、Ms-SNuPE中。在第二种方法中，引物设计为特异地与甲基化的或者未甲基化形式的转化序列退火。如果与靶标具有足够的互补性区域，例如12、15、18或20个核苷酸，那么引物也可以含有另外的不干扰杂交、但对于其它操作有用的核苷酸残基。这种其它残基的例子可以是限制性内切核酸酶剪切、配体结合或者因子结合或连接体或重复序列的位点。寡核苷酸引物可以是或者可以不是这种对修饰的甲基化残基特异的。

[54]区别修饰和未修饰的DNA的一种方式是杂交寡核苷酸引物，该寡核苷酸引物特异地结合到DNA的一种形式或者另一种形式。在杂交后，可以进行扩增反应和测定扩增产物。扩增产物的存在表明与引物杂交的样品。引物的特异性表明DNA是否已经被修饰或未被修饰，其转而表明DNA是否已经被甲基化或未甲基化。例如，亚硫酸氢盐离子修饰非甲基化的胞嘧啶碱基，将它们变为尿嘧啶碱基。在杂交条件下，尿嘧啶碱基与腺嘌呤碱基杂交。因此，包含替代鸟嘌呤碱基的腺嘌呤碱基的寡核苷酸引物会与亚硫酸氢盐修饰的DNA杂交，而含有鸟嘌呤碱基的寡核苷酸引物会与DNA中未修饰的(甲基化的)胞嘧啶残基杂交。使用DNA聚合酶和第二引物的扩增产生能够容易被观察到的扩增产物。这种方法被称为MSP(甲基化特异性PCR；专利5,786,146；6,017,704；6,200,756)。扩增产物可以任选地杂交特异的寡核苷酸探针，而特异的寡核苷酸探针对某些产物也可以是特异的。可选地，可以使用将与来自修饰和未修饰DNA的扩增产物杂交的寡核苷酸探针。

[55]区别修饰和未修饰的DNA的另一种方式是使用对于某些产物也可以是特异的寡核苷酸探针。这类探针可以直接与修饰的DNA或者修饰的DNA的扩增产物杂交。可以使用本领域已知的任何检测系统来标记寡核苷酸探针。这些包括但不限于荧光部分、放射性同位素标记的部分、生物发光部分、发冷光的部分、化学发光的部分、酶、底物、受体或者配体。

[56]鉴定甲基化的CpG二核苷酸的还有另外一种方式是利用McCP2蛋白的MBD结构域选择性地结合到甲基化DNA序列的能力(Cross等，1994；Shiraishi等，1999)。限制性内切核酸酶消化的基因组DNA被加载在表达的His标记的甲基CPG结合结构域上，CPG结合结构域被固定到固体基质和用于制备型柱层析来分离高度甲基化的DNA序列。

[57]实时化学术使得能在反应的早期阶段期间检测PCR扩增，和使得DNA和RNA的定量更容易和更准确。实时PCR的少数变化是已知的。它们包括TaqMan^TM系统和Molecular Beacon(分子信标)^TM系统，它们具有分开的用荧光团和荧光淬灭剂标记的探针。在Scorpion^TM系统中，发夹结构形式的标记的探针被连接到引物。

[58]用许多技术已经成功进行了DNA甲基化分析，其包括MALDI-TOFF、MassARRAY、MethyLight、乙基化等位基因的定量分析(QAMA)、酶区域甲基化测定(ERMA)、HeavyMethyl、QBSUPT、MS-SNuPE、MethylQuant、定量PCR测序和寡核苷酸为基础的微阵列系统。

[59]其沉默被测试和/或检测的基因数量可以变化：一、二、三、四、五或者更多种基因可以被测试和/或检测。在一些情况下，选择至少两种基因。在另外的实施方式中，选择至少三种基因。

[60]可以进行诊断性测试或者结合治疗方案进行测试。测试可以用于监测治疗方案的效力，无论是化学治疗剂或者生物试剂如多核苷酸。测试也可以用于确定什么样的治疗或者预防方案应用到患者上。而且，测试也可以用于把患者分成几组用于测试试剂和确定它们在各组患者上的效力。

[61]用于诊断、预后或者个体化医学用途的测试样品可以从以下获得：外科手术样品如活组织检查或者细针抽出液，石蜡包埋结肠、直肠、小肠、胃、食管、骨髓、乳腺、卵巢、前列腺、肾、肺、脑等器官组织，体液如血液、血清、淋巴、脑脊液、唾液、痰、支气管灌洗液、导管流体粪便、尿液、淋巴结或精液。这些来源不是意欲穷尽性的，而是示例性的。从这些样品或者流体中获得的测试样品包括分离的肿瘤细胞和/或从死亡或者损伤肿瘤细胞中释放的游离核酸。核酸包括RNA、基因组DNA、线粒体DNA、单或双链和蛋白结合的核酸。从这种样品细胞获得的纯化或未纯化形式的任何核酸样品可以用作起始核酸(一种或多种)。

[62]脱甲基剂可以与细胞在体外或者体内接触，目的是恢复细胞的正常基因表达。合适的脱甲基剂包括但不限于5-氮杂-2′-脱氧胞苷、5-氮杂-胞苷、泽布拉恩(Zebularine)、普鲁卡因和L-乙硫氨酸。这个反应可以用于诊断、用于确定倾向和用于确定合适的治疗方案。如果脱甲基剂用于治疗结肠癌、头颈癌、食管癌、胃癌、胰腺癌或肝癌，可以测试基因的表达或者甲基化，所述基因选自：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。

[63]恢复外遗传性沉默的基因表达的可选方式是将非甲基化的多核苷酸引入细胞，这样它将在细胞中表达。各种基因治疗载体和媒介物在本领域中是已知的和任何一种可使用的适合于特定的情况。某些载体适合于短期表达，而某些载体适合于长时间表达。某些载体对于某些器官是有关营养的并且这些载体可以在特定情况下适当使用。载体可以是病毒的或者非病毒的。多核苷酸可以但不是必要的包含在载体例如病毒载体中，并且其可以配制在例如基质中，如脂质体、微泡。通过将多核苷酸给予对象使得其接触细胞并被细胞吸收，多核苷酸可以被引入细胞，并且编码的多肽被表达。优选地，特定多核苷酸将是患者已经被对其测试和被发现携带沉默形式的多核苷酸。用于治疗结肠癌、头颈癌、食管癌、胃癌、胰腺癌、肝癌的多核苷酸将典型地编码选自以下的基因：BOLL、CABYR、EFEMP1、FBLN2、F0XL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。

[64]通过将脱甲基剂给予对象，将通常显示出甲基化沉默基因表达的细胞与与脱甲基剂体内接触。如果方便，可以使用例如导管插入术方法给予脱甲基剂，给予的地方在对象中显示不受调节生长的细胞的位置或者附近，或者给予进入到血流到细胞位置的血管中。类似地，如果待被处理的器官或者其部分可以通过分路方法被分离，试剂可以通过分路给予，因而实质上将试剂提供到含有细胞的位置。试剂也可以全身给予或者通过本领域已知的其它途径给予。

[65]除了多肽编码序列外，多核苷酸可以包括可操作地连接的转录调控元件、翻译调控元件等，和多核苷酸可以是裸露DNA分子的形式，其可以包含在载体中或者其可以配制在基质如脂质体或微泡中，这帮助多核苷酸进入特定的细胞中。术语“可操作地连接的(operatively linked)”指的是两个或者多个相互放置的分子，这样它们作为单一的单元起作用和实现可归因于一个或者两个分子或者其组合的功能。编码期望多肽的多核苷酸序列可以可操作地连接到调控元件，在这种情况下，调控元件以类似于这样的方式在多核苷酸上赋予它的调控作用，在该方式中，调控元件会影响在细胞中其与之正常联系的多核苷酸序列。

[66]编码待被给予哺乳动物或者人或待与细胞接触的期望多肽的多核苷酸可以含有启动子序列——启动子序列可以提供多核苷酸的组成型，或者如果期望，诱导型或者组织特异性或者发育阶段特异性表达、多聚腺苷酸(polyA)识别序列和核糖体识别位点或者内部核糖体进入位点或者其它调控元件如增强子，其可以是组织特异的。载体也可以含有在原核或者真核宿主系统或两者中复制所需要的元件，如所期望的。这种载体——包括质粒载体和病毒载体如噬菌体、杆状病毒、逆转录病毒、慢病毒、腺病毒、牛痘病毒、塞姆利基森林病毒(semliki forest virus)和腺病相关病毒载体——是众所周知的和可以从商业来源购买(Promega，MadisonWL；Stratagene，La Jolla CA.；GIBCO/BRL，Gaithersburg MD.)或者可以由本领域技术人员来构建(参见例如Meth.Enzymol.，Vol.185，Goeddel，ed.(Academic Press，Inc.，1990)；Jolly，Cane.Gene.Ther.1：51-64，1994；Flotte，J.Bioenerg.Biomemb.25：37-42，1993；Kirshenbaum等.，J.Clin.Invest.92：381-387，1993；它们中的每一个在此引入作为参考)。

[67]四环素(tet)诱导型启动子可以用于促使编码期望多肽的多核苷酸的表达。当将四环素或者四环素类似物给予含有可操作地连接到tet诱导型启动子的多核苷酸的对象时，编码多肽的表达被诱导。多核苷酸可选地可以被可操作地连接到组织特异性调控元件，例如肝细胞特异性调控元件如α胎蛋白启动子(Kanai等.，Cancer Res.57：461-465，1997；He等.，J.Exp.Clin.Cancer Res.19：183-187，2000)或者白蛋白启动子(Power等.，Biochem.Biophys.Res.Comm.203：1447-1456，1994；Kuriyama等.，Int.J.Cancer 71：470-475，1997)；肌细胞特异性调控元件如肌红蛋白启动子(Devlin等.，J.Biol.Chem.264：13896-13901，1989；Yan等.，J.Biol.Chem.276：17361-17366，2001)；前列腺细胞特异性调控元件如PSA启动子(Schuur等.，J.Biol.Chem.271：7043-7051，1996；Latham等.，Cancer Res.60：334-341，2000)；胰腺细胞特异性调控元件如弹性蛋白酶启动子(Ornitz等.，Nature 313：600-602，1985；Swift等.，Genes Devel.3：687-696，1989)；白细胞特异性调控元件如增白细胞蛋白(leukosialin)(CD43)启动子(Shelley等.，Biochem.J.270：569-576，1990；Kudo和Fukuda，J.Biol.Chem.270：13298-13302，1995)等，这样多肽的表达限制于个体中的特定细胞或者限制于在培养中，例如在器官培养中的混合细胞群中的特定细胞。包括组织特异性调控元件在内的调控元件在本领域中是众所周知的(参见例如InvivoGen；San Diego Calif.)，许多组织特异性调控元件是商业可获得的。

[68]病毒表达载体可以用于将多核苷酸引入细胞中，特别是受试者的细胞中。病毒载体提供了它们能够以相对高的效率感染宿主细胞和能够感染特定细胞类型的优势。例如，编码期望多肽的多核苷酸可以被克隆进入杆状病毒载体，其随后可以用于感染昆虫宿主细胞，由此提供了产生大量的编码多肽的方法。病毒载体已被开发用在特定宿主系统，特别是哺乳动物系统中，病毒载体包括例如逆转录病毒载体、其它慢病毒载，如那些基于人类免疫缺陷病毒(HIV)的载体、腺病毒载体、腺相关病毒载体、疱疹病毒载体、肝炎病毒载体、牛痘病毒载体等(参见Miller和Rosman，BioTechniques 7：980-990，1992；Anderson等.，Nature 392：25-30Suppl.，1998；Verma和Somia，Nature 389：239-242，1997；Wilson，New Engl.J.Med.334：1185-1187(1996)，它们中的每一篇在此引入作为参考)。

[69]多核苷酸——其可以任选地包含在载体中——可以通过在本领域中已知的各种方法中的任一种被引入细胞(Sambrook等.，supra，1989；Ausubel等.，CurrentProtocols in Molecular Biology，John Wiley and Sons，Baltimore，Md.(1987和supplements through 1995)，它们中的每一篇在此引入作为参考)。这些方法包括例如转染、脂转染、显微注射、电穿孔和用病毒载体进行的感染；和可以包括应用脂质体、微乳液等，脂质体、微乳液等可以帮助将多核苷酸引入细胞和可以保护多核苷酸在引入细胞之前免于降解。特别有用的方法包括使多核苷酸并入微泡，微泡可以注射入循环中。可以放置超声源，这样超声被传送给肿瘤，其中由于超声，含有多核苷酸的循环微泡在肿瘤位置被破裂，因此在癌症的位置提供多核苷酸。特定方法的选择将依赖于例如多核苷酸被引入的细胞以及细胞是否在培养中或在体内原位位置。

[70]通过用病毒载体感染而将多核苷酸引入细胞可以有效地将核酸分子引入细胞。而且，病毒是非常特异的，并可以根据在一种或者几种特定细胞类型中的感染和繁殖的能力，来选择病毒作为载体。因此，它们天然的特异性可以用于将包含在载体中的核酸分子靶向特定的细胞类型。基于HIV的载体可以用于感染T细胞、基于腺病毒的载体可以用于例如感染呼吸道上皮细胞、基于疱疹病毒的载体可以用于感染神经细胞等。其它载体，如腺相关病毒可以具有更大的宿主细胞范围，因而可以用感染各种细胞类型，虽然病毒或者非病毒载体也可以用特定的受体或者配体修饰，以通过受体介导的事件来改变靶标特异性。本发明的多核苷酸或者含有多核苷酸的载体可以包含在细胞，例如宿主细胞中——宿主细胞使得含有多核苷酸的载体得以繁殖，或者辅助细胞中——辅助细胞使得含有多核苷酸的病毒载体得到包装。多核苷酸可以短暂地包含在细胞中，或者可以由于例如整合进入细胞基因组中而被稳定维持。

[71]由基因(BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345或ZNF655)编码的多肽可以直接给予到在受试者中显示出不受调节的生长的细胞部位。如果期望的话，多肽可以使用本文公开的方法产生、分离和配制，并且多肽可以与细胞接触，这样多肽可以穿过靶细胞的细胞膜。多肽可以作为融合蛋白的一部分提供，融合蛋白包括有利于转运通过细胞膜的肽或者多肽成分。例如，人类免疫缺陷病毒(HIV)TAT蛋白转导结构域或者核定位结构域可以融合到感兴趣的标记。给予的多肽可以配制在基质中，基质帮助多肽进入细胞。

[72]虽然在这里提到了特定多核苷酸和多肽序列作为已知基因和蛋白的代表，但是本领域技术人员会理解，在数据库中的序列代表了在特定个体中存在的序列。来自其它个体的任何等位基因序列也可以使用。这些典型地与公开的序列变化1-10残基、1-5个残基或者1-3个残基。而且，等位基因序列与数据库序列典型地具有至少95、96、97、98或者99％的同一性，同一性如使用运算法则如BLAST同源性工具进行测量。

[73]试剂如脱甲基剂、多核苷酸或多肽典型地配制在适合给予受试者的组合物中。因此，本发明提供了含有试剂的组合物，该试剂可用于恢复细胞受调节的生长，该细胞由于一种或者多种基因的甲基化沉默转录而显示出不受调节的生长。试剂作为治疗患有与这种不受调节生长相关的病理状况的受试者的药物是有用的。这种药物通常包括载体。可接受的载体在本领域中是众所周知的和包括例如水溶液诸如水或者生理缓冲盐水或者其它溶剂或者媒介物如乙二醇、丙三醇，油如橄榄油或者可注射的有机酯。可接受的载体可以含有生理上可接受的化合物，化合物起例如稳定或者增加结合物的吸收的作用。这种生理上可接受的化合物包括例如糖类如葡萄糖、蔗糖或葡聚糖，抗氧化剂如抗坏血酸或谷胱甘肽，螯合剂、低分子量蛋白或者其它稳定剂或者赋形剂。本领域技术人员会知道或者能够容易地确定可接受载体，包括生理上可接受的化合物。载体的性质依赖于治疗剂的物化性质和组合物的给药途径。治疗剂或者药物的给予可以通过口服途径或肠胃外途径例如静脉内、肌内、皮下、经皮、鼻内、支气管内、阴道、直肠、瘤内途径或者在本领域中已知的其它方法进行。药物组合物也可以含有一种或者多种另外的治疗剂。

[74]治疗剂可以包含在封装材料里面，例如包含在水包油乳液、微乳液、胶束、混合胶束、脂质体、微球体、微泡或者其它聚合物基质中(参见例如Gregoriadis，Liposome Technology，Vol.1(CRC Press，Boca Raton，FIa.1984)；Fraley，等.，TrendsBiochem.Sci.，6：77(1981)，它们中的每一个在此引入作为参考)。例如由磷脂或其它脂类组成的脂质体是无毒的、生理上可接受的可代谢载体，其制备和施用相对简单。“隐形(Stealth)”脂质体(参见例如美国专利5,882,679；5,395,619；和5,225,212，它们中的每一篇在此引入作为参考)是这种封装材料的例子，其对于制备在本发明方法中有用的组合物特别有用，另外其它“掩蔽(masked)”脂质体可以类似地使用，这种脂质体延长治疗剂停留在循环中的时间。例如阳离子脂质体也可以用特定的受体或者配体进行修饰(Morishita等.，J.Clin.Invest.，91：2580-2585(1993)，其在此引入作为参考)。另外，多核苷酸剂可以使用例如腺病毒多聚赖氨酸DNA复合物引入细胞中(参见例如Michael等.，J.Biol.Chem.268：6866-6869(1993)，其在此引入作为参考)。

[75]含有治疗剂的组合物的给药途径将部分依赖于分子的化学结构。多肽和多核苷酸例如口服输送不是有效的，因为它们在消化道中可被降解。然而，例如可以使用化学修饰多肽的方法，使它们更不易被内源性蛋白酶降解，或者使它们更容易通过消化道吸收(参见例如Blondelle等.，supra，1995；Ecker和Crook，supra，1995)。

[76]在实施本发明的方法中给予的试剂总量可以作为单剂量——或者作为大丸剂或推注剂(弹丸，bolus)或者通过在相对短的时间段中输注——给予受试者，或其可以使用分次治疗方案进行给予，在分次治疗方案中多剂量在长时间段中给予。本领域技术人员会知道，在受试者中治疗病理症状的组合物的量依赖于多种因素，包括受试者的年龄和总体健康以及给药途径和给予的治疗次数。考虑到这些因素，本领域技术人员会根据需要调整具体的剂量。一般而言，最初使用I期和II期临床试验来确定组合物的配方和给药的途径及频率。

[77]组合物可以配制用于口服制剂，例如片剂或者溶液或者悬浮液的形式；或者组合物可以包含与适合于肠内或者非肠道应用的有机或者无机载体或者赋形剂的混合物，和可以例如与常用、无毒、药学上可接受的载体化合，用于制备片剂、丸剂、胶囊、栓剂、溶液、乳剂、悬浮剂或者其它适合应用的形式。除了在以上所公开的那些载体外，载体可以包括葡萄糖、乳糖、甘露糖、阿拉伯胶、明胶、甘露醇、淀粉糊、三硅酸镁、滑石、玉米淀粉、角蛋白、胶体二氧化硅、马铃薯淀粉、尿素，中链长度甘油三酯、葡聚糖和适合用于制造固体、半固体或液体形式的制备物的其它载体。另外，辅助剂、稳定剂、增稠剂或者着色剂和香料也可以应用，例如稳定干燥试剂如丙酮糖(triulose)(参见例如美国专利5,314,695)。

[78]虽然通过使用标记的组合可以获得诊断和预后的准确性和灵敏性，例如5或者6种标记、或者9或10种标记、或者14或15种标记的组合，但是实际考虑可能决定使用更小的组合。特定癌症的标记的任何组合可以被使用，所述组合包含2、3、4或5种标记。考虑到本文提供的单个标记的具体公开，可以容易地想到2、3、4或5种标记的组合。

[79]差别甲基化GpG岛的甲基化水平可以提供关于疾病或者癌症的各种信息。它可以用于在个体中诊断初癌或者癌症。初癌或者癌症前体是癌症的非常早的阶段，它在结肠的最里(腔层)层中发现。它有时称为浅表癌(superficial cancer)。可选地，它可以用于预测在个体中疾病或者癌症的过程，或者预测在个体中对疾病或者癌症的易感性，或者对个体中疾病或者癌症的进展进行分级。它可以帮助预测整体存活的可能性或预测疾病或癌症再次发生的可能性，并确定个体所经历的疗程的有效性。当检测时，与参考水平相比的甲基化水平增加或者减少和增加/减少的改变提供了有用的预后和诊断价值。

[80]预后的方法可以用于鉴定可能发展为癌的腺瘤患者。这种预测可以根据在腺瘤中相对于正常的组织在表1(图9)中所鉴定的至少一种基因的外遗传沉默来进行。这些患者可以被提供另外合适的治疗或者预防选择，包括内镜息肉切除术或者切除术，和当指出时，包括外科手术、化疗、放疗、生物反应调节剂或其它疗法。这些患者也可以接受进一步诊断或者监测程序的建议，诊断或者监测程序包括但不限于增加频率的结肠镜检查、乙状结肠镜检查、虚拟结肠镜检查、视频囊内镜检查、PET-CT、分子成像或其它成像技术。

[81]治疗癌症患者的治疗策略可以根据外遗传沉默基因的再激活进行选择。首先鉴定选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因，所述基因在患者癌细胞中的表达通过去甲基化试剂再激活或者外遗传沉默。随后选择增加基因表达的治疗。这种治疗可以包括给予再激活剂或者多核苷酸。可选地可以给予多肽。

[82]依照本发明的试剂盒是用于测定甲基化的试剂的集合体。它们典型地在含有所有成分的包装中，任选地包括说明书。包装可以分开，以便各成分不混合，直到希望混合时。成分可以处于不同的物理状态。例如，一些成分可以是冻干的，而一些在水溶液中。一些成分可以是冷冻的。在试剂盒内，单个的成分可以分开包装。试剂盒可以含有如上描述的用于差异性修饰甲基化和非甲基化胞嘧啶残基的试剂。理想地，试剂盒将含有寡核苷酸引物，该寡核苷酸引物与基因/标记的转录起始位置的1kb内的区域特异性杂交，所述基因/标记为：BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。典型地，试剂盒将包含单个基因或者标记的正向和反向引物。如果具有足够的互补区域，例如12、15、18或20个核苷酸，那么引物也可以包含另外的核苷酸残基，这些核苷酸残基不干扰杂交，但是对其它操作可能是有用的。这种其它残基的例子可以是限制性内切核酸酶剪切的位点，用于配体结合或者用于因子结合或者连接体或者重复序列的位点。寡核苷酸引物可以或者可以不对修饰的甲基化残基是特异的。试剂盒可任选地含有寡核苷酸探针。探针可以对含有修饰的甲基画残基的序列或者对含有非甲基化残基的序列是特异的。试剂盒可以任选地含有修饰甲基化胞嘧啶残基的试剂。试剂盒也可以含有用于进行扩增的成分，例如DNA聚合酶和脱氧核糖核苷酸。检测工具也可以在试剂盒中提供，包括在引物或者探针上的可检测的标记。试剂盒也可以含有用于检测本发明的一种标记(表1；图9)的基因表达的试剂。这些试剂可以包括例如探针、引物或者抗体。在酶或者配体的情况下，底物或者结合伴侣可以用于评估标记的存在。

[83]在这个实施方式的一方面，基因与肼接触，肼修饰胞嘧啶残基，但是不修饰甲基化的胞嘧啶残基，随后肼处理的基因序列与试剂如哌啶接触，该试剂在肼修饰的胞嘧啶残基处剪切核酸分子，由此产生包含片段的产物。通过使用例如电泳、色谱或者质谱的方法依照分子量分离片段，并比较该分离形式与类似处理的相应非甲基化基因序列的分离形式，缺口在含有甲基化胞嘧啶残基的测试基因中的位置上是明显的。因此，缺口的存在指示了在测试细胞的靶基因的CpG二核苷酸中胞嘧啶残基的甲基化。

[84]亚硫酸氢盐离子例如亚硫酸氢钠将非甲基化的胞嘧啶残基转化为亚硫酸氢盐修饰的胞嘧啶残基。亚硫酸氢盐离子处理的基因序列可以被暴露于碱性条件，碱性条件将亚硫酸氢盐修饰的胞嘧啶残基转化为尿嘧啶残基。亚硫酸氢钠容易与胞嘧啶的5，6-双键反应(但是与甲基化的胞嘧啶反应很差)形成磺酸化的胞嘧啶反应中间产物，中间产物易于脱氨基，产生磺酸化的尿嘧啶。磺酸盐基团可以通过暴露于碱性条件来除去，引起尿嘧啶的形成。DNA可以例如通过PCR扩增，并进行测序来确定在样品的DNA中CpG位置是否被甲基化。尿嘧啶被Taq聚合酶识别为胸腺嘧啶，而当PCR时，生成的产物仅在起始模板DNA中5-甲基胞嘧啶存在的地方含有胞嘧啶。本领域技术人员可以比较在测试细胞的亚硫酸氢盐离子处理的基因序列中尿嘧啶残基的量或者分布与类似处理的相应非甲基化基因序列中的尿嘧啶残基的量或者分布。在测试细胞的基因中尿嘧啶残基的量或者分布的减少表明在测试细胞基因的CpG二核苷酸中胞嘧啶残基的甲基化。尿嘧啶残基的量或者分布也可以通过如下步骤检测：将亚硫酸氢盐离子处理的目标基因序列与寡核苷酸接触、随后暴露于碱性条件并检测寡核苷酸的选择性的杂交(或者其不存在)，所述寡核苷酸选择性地与目标基因的核苷酸序列杂交，该目标基因或者含有尿嘧啶残基或者缺少尿嘧啶残基，但不是两者。

[85]测试化合物可以被测试它们治疗癌症的潜力。用于测试的癌细胞可以选自前列腺癌、肺癌、乳腺癌和结肠癌。确定选自那些在表1(图9)中列出的基因的表达，如果表达在细胞中被化合物增加，或者如果基因的甲基化在细胞中被化合物减少，本领域技术人员可以鉴定该化合物具有作为治疗癌症的潜力。

[86]可选地，这些测试可以用于确定食管癌、头颈癌、胃癌、小肠癌、胰腺癌、肝癌患者对化疗剂的反应。患者可以用化疗剂进行治疗。如果选自BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、SOX17、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXE1、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655的基因的表达在癌细胞中被化合物增加，或者如果基因的甲基化在癌细胞中被化合物减少，该化合物可以被选择用于治疗患者。

[87]以上公开总体描述了本发明。所有在本文公开的参考文献通过引用明确并入。更完整的理解可以通过参考以下具体的例子来获得，其在本文提供仅仅为了举例说明的目的，而不是意欲限制本发明的范围。

实施例

实施例1

材料和方法

[88]细胞培养和处理。HCT116细胞和等基因遗传敲除衍生物如在以前描述(14)地来维持。对于药物处理，对数期CRC细胞在McCoys 5A培养基(Invitrogen)中培养96小时，McCoys 5A培养基含有10％BCS和1×青霉素/链霉素与5μM的5氮杂-脱氧胞苷(DAC)(Sigma；储液：1mM，在PBS中)，每24小时更换培养基和DAC。用300nM曲古柳菌素A(Sigma；储液：溶解在乙醇中的1.5mM)处理细胞18小时。对照细胞平行进行模拟处理，加入没有药物的等体积PBS或者乙醇。

[89]微阵列分析。依照制造商的指导——包括DNA酶消化步骤，使用Triazol(Invitrogen)和RNeasy试剂盒(Qiagen)从对数期细胞收获总RNA。使用NanoDropND-100，接着用2100Bioanalyzer(Agilent Technologies)进行质量评价，对RNA定量。个体样品的RNA浓度大于200ng/ul、28s/18s比率大于2.2，和RNA完整值为10(10为最高分)。使用低RNA输入荧光线性扩增试剂盒(Low RNA InputFluorescent Linear Amplification Kit)(Agilent Technologies)，依照制造商的指导，进行样品扩增和标记过程。标记的cRNA用RNeasy小型试剂盒(Qiagen)纯化和定量。在扩增之前，RNA示踪对照(RNA spike-in control)(Agilent Technologies)加入到RNA样品中。标记有Cy3或Cy5的0.75微克样品与对照靶标(AgilentTechnologies)混合，依照Agilent微阵列方案聚集在寡微阵列(Oligo Microarray)上、杂交和处理。用Agilent G2565BA微阵列扫描仪，使用Agilent Technologies推荐的设置进行扫描。

[90]数据分析。所有阵列进行制造商所推荐的质量检查。视觉检查图像的假象，检测信号的分布和红和绿两个通道的背景强度以鉴定异常的阵列。没有观察到不规则，并且保留和使用所有阵列。使用R统计计算平台(23)和来自Bioconductor生物信息软件项目(24)的程序包进行所有的计算。红信号与绿信号的对数比在减去背景和LoEss归一化后进行计算，如在Bioconductor(25、26)的半度软件包(limma package)中所执行地。单个阵列换算到有相同的四分位数(inter-quartile)范围(第75个百分位数-第25个百分位数)。对于染色交换重复(dye-swap replicate)微阵列，对数倍数变换进行平均，以产生每种条件的单一的一组表达值。

[91]甲基化和基因表达分析。依照制造商的指导，用TRIzol试剂(Invitrogen)分离RNA。对于反转录-PCR(RT-PCR)，1μg的总RNA通过使用Ready-To-GoTMYou-Prime First-Strand Beads(Amersham Biosciences)进行反转录，加入随机六聚体(每个反应0.2μg)。对于RT-引物设计，我们使用Primer3(http://frodo.wi.mit.edu/cgi-bin/primer3/primer3_www.cgi)。对于MSP分析，依照标准的酚-氯仿提取方法提取DNA。使用EZ DNA甲基化试剂盒(Zymo Research)进行基因组DNA的亚硫酸氢盐修饰。使用MSPPrimer(http://www.mspprimer.org)，设计对未甲基化和甲基化启动子序列特异的引物序列。MSP如以前描述(20)进行。所有PCR产物(50μl总体积的15μl用于RT-PCR和25μl总体积的7.5μl用于MSP)直接加样在含有GelStar Nucleic Acid Gel Stain(Cambrex Bio Science)的2％琼脂糖凝胶上，并在紫外线照射下可视化。根据要求，用于MSP、亚硫酸氢盐测序和RT-PCR的引物序列和条件可从作者得到。

[92]人肿瘤分析。来自原发性CRC的福尔马林固定的、石蜡包埋的组织从Department of Pathology of the University Hospital Maastricht的档案库获得。获得了马斯特里赫特大学(Maastricht University)、马斯特里赫特大学医院(UniversityHospital Maastricht)和美国约翰霍普金斯大学医院(Johns Hopkins UniversityHospital)的医学伦理委员会的批准。使用Puregene DNA分离试剂盒(GentraSystems)分离DNA。

实施例2

[93]对于过度甲基化依赖基因表达变化的综合鉴定，我们的第一步通过在基因组宽表达阵列为基础的方法中比较野生型HCT116CRC细胞与携带两种主要人类DNA甲基转移酶的单独和组合的基因删除的等基因伴侣细胞来进行(图1A，14)。重要地是，在DNMT1^(-/-)DNMT3b^(-/-)双敲除(DKO)HCT116细胞中——其实际上完全丧失了全部的5-甲基胞嘧啶，所有以前单个检查的过度甲基化基因——在野生型细胞中缺少基本表达——经受了伴随基因重新表达的启动子脱甲基化(14-17)。通过依照在44K Agilent Technologies阵列平台上的改变的信号强度将基因分级，当与等基因野生型亲代细胞或者等基因细胞系比较时，我们观察到了在DKO细胞中基因表达增加的独特峰，在等基因野生型亲代细胞或者等基因细胞系中DNMT的1或3b已经被个别地删除，其包含在DNA甲基化中最小的变化(图1B)。

[94]根据我们以前的方法，我们使用药理学策略测试了我们的方法，但是现在被明显地改良以提供全转录物组覆盖(19)，以鉴定在任何癌细胞系中沉默的过度甲基化基因。对于致密的过度甲基化的和转录无活性的基因，DNA脱甲基剂5-氮杂-2′-脱氧胞苷(DAC)具有充分确立的诱导基因重新表达的能力(18)。另一方面，对于这些相同的基因，I和II类HDAC抑制剂曲古柳菌素A(TSA)将不单独诱导重新表达(19)。在用DAC或者TSA处理HCT116细胞后(图1C)，我们鉴定到这样的区域，在其中基因表达没有随着TSA增加(＜1.4倍)和在模拟处理的细胞中没有显示可检测的表达。在这个区域内，我们观察到了DAC诱导的基因表达的特征峰，其与在DKO细胞中所看见的基因表达增加相重叠(比较在图1D中黄色点与在图1B中的蓝色点)。由于DAC整合入分裂细胞的DNA，而我们的处理仅仅进行了96小时，与DKO细胞相比，在药理学方法中检测基因增加的灵敏性被降低。这个基因峰的鉴定完全依赖于对没有对HDAC抑制作出反应的唯一的基因进行分析，被簇分析加强，簇分析显示了在DKO和DAC处理细胞的基因之间的亲密关系，在TSA单独处理后，DKO和DAC处理的细胞具有单独分组的基因表达变化(图1E)。这些数据确认了覆盖很少基因组的先前研究，在其中，带有致密CpG岛的被TSA再表达的基因没有包含可检测的甲基化(19)。基因表达增加的类似峰可以在5种另外的人CRC细胞系(SW480、CaCO2、RKO、HT29和COLO320)中看见，确认了这种方法在癌细胞系中普遍起作用(图2A)。

实施例3

[95]为了说明我们新阵列方法鉴定CpG岛过度甲基化基因的灵敏性，我们首先检查了在HCT116细胞中11种已知被过度甲基化、完全沉默和在DAC处理后重新表达的基因(图4(S1A))(14-17)。所有测试的基因保持在TSA未反应区内(图4(S1B和C))，在DAC处理和DKO细胞中，表达变化的方向充分关联(图4(S1D))。重要地是，对于DAC增加，5种指导基因(45％)增加2倍或者2倍以上，以及另外3种基因或者总共73％的基因增加1.3倍或者1.3倍以上。

[96]根据在DKO与DAC诱导基因增加之间所观察到的灵敏性差异和指导基因在阵列平台中的行为，在TSA阴性区域内，我们指定了基因的上层(2倍增加或者以上)和下层(1.4倍至2倍之间的增加)来鉴定过度甲基化癌基因(图2B)。我们也从这些区域中根据它们在未处理的细胞中没有基本表达来挑选基因。事实上，在HCT116细胞中，总共532个基因的上层反应区中35个随机挑选的基因中的30个基因(86％)，和来自318个上层基因的48个这样的SW480细胞基因的31个基因(65％)证明被CpG过度甲基化——如通过MSP(20)所测量的，和在来源的细胞系中被沉默——如通过RT-PCR测量的(图5、7(S2、S4)。我们也检测了在DAC处理的HCT116细胞的下层中过度甲基化基因的发现效率。在这个区域中的鉴定的1190个基因中，35个随机挑选的含有CpG岛的基因中的17个(49％)被过度甲基化，具有一致的基因沉默(图6(S3))。这说明了与以前鉴定新的癌过度甲基化基因的筛查相比(7、21)，我们的方法是特别有效的。以这种证实的过度甲基化的水平，我们计算在HCT116细胞中过度甲基化组由估计的1040个基因组成和对于SW480细胞由估计的579个基因组成(对于计算的详细描述，参见图8(表S1))。过度甲基化组估计为从在CaCO2中的532个基因到RKO细胞中的1389个基因的范围(图8(表S1))。在6个细胞系的所有层中鉴定到总共5906个独特的基因，每个细胞系产生平均大约1000个过度甲基化组基因。

实施例4

[97]在细胞培养为基础的方法中根本的问题为是否它们鉴定了在原发性肿瘤中作为失活靶标的基因。为了解决这个问题，来自证实的基因清单的含有CpG岛的20个基因被从HCT116上层(17个基因)、HCT116下层(2个基因)或SW480上层(1个基因)中随机选择，和分析在一组CRC细胞系中的甲基化。所有测试的基因在2个或多个细胞系中被过度甲基化(图3A)。随后我们检测了在一组20个到61个原发性结肠癌和20个到40个正常出现的结肠组织样品中的这20个基因的状况，正常出现的结肠组织样品从无癌的个体中获得。在正常结肠组织样品中，大部分基因(65％)完全没有被甲基化或者很少甲基化，但在绝大多数原发性肿瘤中(86％)被甲基化(图3A)。分析的20个基因中，13个基因(65％)满足在细胞系中具有高频率甲基化的“肿瘤特异性甲基化”的标准，在正常结肠中低的或者未检测到的甲基化和在肿瘤样品中频繁的甲基化。我们策略的效率揭示在细胞系中对于鉴定过度甲基化基因至少二分之一(1/2)的发现率，和对于鉴定癌症特异性过度甲基化基因至少三分之一(1/3)的发现率。

实施例5

[98]虽然清楚的是，遗传和外遗传机制对人类肿瘤发生的起始和进展都是重要的，但是对这些改变的每个的相对贡献了解不多。对少数癌基因甲基化和突变频率之间的比较还没有令人信服地证明任一途径的普遍性。重要地是，还没有进行全基因组分析来质疑这个问题。

[99]在最近的癌基因全基因组测序中，

等(3)观察到突变一般而言具有低的发生率，鉴定的90％的基因包含小于10％的突变频率。此外，典型的结肠或者乳腺癌每个单个肿瘤仅含有平均11个突变，单个肿瘤之间具有很少的重叠。这些低频率提出了这样的问题：是否可选的机制可能在另外的肿瘤中导致这些基因的失活。显然，我们现在在个体肿瘤中鉴定到数量大得多的候选过度甲基化基因(图2C)，这表示这种外遗传改变可能为许多肿瘤抑制基因的突变提供了可选的失活途径。

[100]当我们搜索候选过度甲基化基因和189种突变癌(CAN)基因之间的匹配时，筛查肿瘤的遗传和外遗传变化的重要性被显著加强。我们首先质疑我们5906个过度甲基化组基因清单与在乳腺和CRC肿瘤中鉴定的CAN基因清单。这鉴定了这56种共有基因，其中45种含有CpG岛。这些45种基因中的26种(58％)——类似于如上所述鉴定的所有候选基因的证实率——证明在6个细胞系的至少1个中被过度甲基化，并被选择用于进一步研究。重要地是，正好一半的基因(13种基因)在正常结肠中未被甲基化，但是在原发性CRC肿瘤中被甲基化(图3B、C)，给出了鉴定肿瘤特异性甲基化的50％的频率。对于事实上每种检查的基因，过度甲基化的发生率显著高于突变的发生率(图3D)。因此，不同于突变的基因，大多数基因的过度甲基化在许多肿瘤之间是共有的性质。在先前未表征的基因中这些外遗传沉默和突变的发现巩固了它们作为肿瘤抑制基因的可能作用。(图3E)。

实施例6--收集的BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB的另外组织数据

材料和方法

用于组织确认的临床样品

[101]对应于77个正常组织和94个癌样品，总共171个结肠石蜡包埋的组织样品使用实时MSP进行处理。表2给出了用于组织确认的样品组的概述。

表2-临床样品组的详细资料

石蜡包埋组织样品的DNA提取

[102]福尔马林固定的石蜡包埋样品首先在750μl的二甲苯中去除石蜡2小时。然后，在以13000rpm离心15分钟之前，加入250μl的70％的乙醇。除去上清液，并在室温下空气干燥样品20分钟。使用经典的酚/氯仿提取方法提取DNA，并在50μl的LoTe(3mM TRIS，0.2mM EDTA，pH 8.0)中重悬浮。随后，使用

dsDNA定量试剂盒(Molecular Probes，Invitrogen)，依照制造商的推荐对DNA定量。随试剂盒提供的λDNA用于制备标准曲线(从1到800ng/ml)。使用FluoStar Galaxy平板读取器(BMG Lab technologies，德国)收集数据。

DNA修饰

[103]使用EZ-96DNA甲基化试剂盒(Zymo Research)，依照制造商的方案，1μg的DNA在移液自动机(Tecan)上以96孔形式进行亚硫酸氢盐修饰。基本上，等份的45μl与5μl的M-稀释缓冲液(M-Dilution Buffer)混合，并在37℃以1100rpm摇动温育15分钟。接着加入100μl的稀释的CT转化试剂，样品在70℃、在黑暗中以1100rpm摇动温育3小时。在转化后，通过在冰上温育10分钟进行和加入400μl的M-结合缓冲液对样品脱盐。样品加样到收集盘中的Zymo-Spin I柱上，并离心后，用200μl的M-洗涤缓冲液(M-Wash Buffer)洗涤。200μl的M-去磺化缓冲液(M-Desulphonation Buffer)放置在柱上并在室温温育15分钟。在柱子离心后，它们用200μl的M-洗涤缓冲液洗涤2次。最后，DNA在125μl Tris-HCl 1mM pH8.0中从柱上洗脱和储存在-80℃，直到进一步的处理。

DNA扩增

[104]在7900HT快速实时PCR系统上(Applied Biosystems)应用实时MSP。5μl修饰的DNA加到PCR混合物(总体积10μl)中，PCR混合物含有缓冲液(16.6mM(NH4)2SO4、67mM Tris(pH 8.8)、6.7mM MgCl2、10mM β-巯基乙醇)、dNTPs(5mM)、正向引物(6ng)、反向引物(18ng)、分子信标(0.16μM)和JumpstartDNA Taq聚合酶(0.4单位；Sigma Aldrich)。用于每个基因的引物序列和分子信标序列总结在表3中。使用如下循环程序：5分钟95℃，接着45个30秒95℃、30秒57℃和30秒72℃的循环。包括标准曲线(2×10^6-20拷贝)以通过内插它们的Ct值到标准曲线来确定未知样品的拷贝数。

表3-引物序列和信标序列

在组织材料上的标记确认

[105]如以上所描述进行实验。使用在表3中详述的引物对和信标探针在组织材料上确认结肠标记：BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB。另外，测量独立的参考β-肌动蛋白(ACTB)。使用SDS 2.2软件(Applied Biosystems)产生结果并以Ct值(扩增曲线超过阈值的循环数量，由软件自动设定)输出。使用标准曲线推算拷贝数。每个样品的感兴趣基因与ACTB的比率(乘以1000)用作测量值，代表在每个样品内每个感兴趣基因的甲基化DNA的相对水平。

[106]在正常样品中(对照)和癌症(病例)中BNIP3、FOXE1、SYNE1、SOX17、JAM3、MMP2和GPNMB的甲基化特异性PCR散射图在图10-16中显示。测量值表示为甲基化比率，定义为与ACTB比较每个基因的荧光强度值的比率，乘以1000，以便容易作表。

[107]如在图10-16中所指出，在调查的对照和病例组之间，观察到清楚的比率差异。

参考文献

1.Ponder B.A.Cancer genetics.Nature 411，336-41(2001).

2.Herman，J.G.&Baylin，S.B.Gene silencing in cancer in association withpromoter hypermethylation.N Engl J Med 349，2042-54(2003).

3.

T.et al.The consensus coding sequences of human breast andcolorectal cancers.Science 314，268-74(2006).

4.Antequera，F.&Bird，A.Number of cpg islands and genes in human andmouse.Proc Natl Acad Sci U S A 90，11995-11999(1993).

5.Costello，J.F.et al.Aberrant CpG-island methylation has non-random andtumour-type-specific patterns.Nat.Genet.24，132-138(2000).

6.Suzuki，H.et al.A genomic screen for genes upregulated by demethylation andhistone deacetylase inhibition in human colorectal cancer.Nat Genet 31，141-9(2002).

7.Gius，D.et al.Distinct effects on gene expression of chemical and geneticmanipulation of the cancer epigenome revealed by a multimodality approach.CancerCell 6，361-71(2004).

8.Paz，M.F.et al.Genetic unmasking of epigenetically silenced tumor suppressorgenes in colon cancer cells deficient in DNA methyltransferases.Hum Mol Genet 12，2209-19(2003).

9.Weber，M.et al.Chromosome-wide and promoter-specific analyses identifysites of differential DNA methylation in normal and transformed human cells.NatGenet 37，853-62(2005).

10.Hu，M.et al.Distinct epigenetic changes in the stromal cells of breastcancers.Nat Genet 37，899-905(2005).

11.Toyota，M.et al.Identification of differentially methylated sequences incolorectal cancer by methylated CpG island amplification.Cancer Res 59，2307-12(1999).

12.Keshet，I.et al.Evidence for an instructive mechanism of de novomethylation in cancer cells.Nat Genet 38，149-53(2006).

13.Ushijima，T.Detection and interpretation of altered methylation patterns incancer cells.Nat Rev Cancer 5，223-31(2005).

14.Rhee，I.et al.DNMT1 and DNMT3b cooperate to silence genes in humancancer cells.Nature 416，552-6(2002).

15.Toyota，M.et al.Epigenetic inactivation of CHFR in human tumors.ProcNatl Acad Sci U S A 100，7818-23(2003).

16.Suzuki，H.et al.Epigenetic inactivation of SFRP genes allows constitutiveWNT signaling in colorectal cancer.Nat Genet 36，417-22(2004).

17.Akiyama，Y.et al.GATA-4 and GATA-5 transcription factor genes andpotential downstream antitumor target genes are epigenetically silenced in colorectaland gastric cancer.Mol Cell Biol 23，8429-39(2003).

18.Christman J.K.5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors ofDNA methylation：mechanistic studies and their implications for cancer therapy.Oncogene 21，5483-95(2002).

19.Cameron，E.E.，Bachman，K.E.，Myohanen，S.，Herman，J.G.&Baylin，S.B.Synergy of demethylation and histone deacetylase inhibition in the re-expression ofgenes silenced in cancer.Nat Genet 21，103-7(1999).

20.Herman，J.G.，Graff，J.R.，Myohanen，S.，Nelkin，B.D.&Baylin，S.B.Methylation-specific PCR：a novel PCR assay for methylation status of CpG islands.Proc Natl Acad Sci U S A 93，9821-6(1996).

21.Yamashita K，Upadhyay S，Osada M，Hoque MO，Xiao Y，Mori M，Sato F，Meltzer SJ，Sidransky D.Pharmacologic unmasking of epigenetically sileneed tumorsuppressor genes in esophageal squamous cell carcinoma.Cancer Cell 2 485-95(2002).

22.Egger，G.，Liang，G.，Aparicio，A.&Jones，P.A.Epigenetics in humandisease and prospects for epigenetic therapy.Nature 429，457-63(2004).

23.Ihaka，R.&Gentleman，R.C.R：A language for data analysis and graphics.Journal of Computational and Graphical Statistics 5，299-314(1996).

24.Gentleman，R.C.et al.Bioconductor：open software development forcomputational biology and bioinformatics.Genome Biol 5，R80(2004).

25.Smyth，G.K.&Speed，T.Normalization of cDNA microarray data.Methods 31，265-73(2003).

26.Smyth，G.K.，Yang，Y.H.&Speed，T.Statistical issues in cDNA microarraydata analysis.Methods Mol Biol 224，111-36(2003)。

序列表

<110>S.拜林

<120>结肠癌的早期检测和预后

<130>006791.00012

<160>250

<170>FastSEQ for Windows Version 4.0

<210>1

<211>1200

<212>DNA

<213>智人(Homo sapiens)

<400>1

ccgcctcctc tccattttac agaggaggaa accgagggtt gagcggcgaa tgatttgccc 60

tgcctgccca gcacggaaaa aaatcactct tctggcccca gtcgcctccc tttctgtgct 120

gtgagtctgt gtccagagca ggaagggctg ctccgagctg cagggacggg ctctgtgtgt 180

taaaccttca aatggcttcc agggactcat ggagcatcca ggacacctgg agatggcgac 240

tcctgggacc cctggccctt ccctcctctg gccttcggtc cgtgagggtg aattaagtgt 300

gccacccacc aggggcagag acacatggag acagagattg agagacagag aacagagggg 360

gagacagaaa gagagaggga catgaagagc aacggagtta caggaggatc tgacgctccg 420

ttggggagac agggagaaat gtggggagat gcagcgtccc aggtgctccc cagtggccct 480

gcccctcctc ccctctcccc tccccaccag gcaggaccct cagggagctc cagcctggac 540

ccgaaccctg tcccaccctg acgcacctgc accaggccag gctggacctg tggggtgggt 600

gcaggcctgg ccccagcccg gccactgccc tggaaacccc tcccccgcca agatgctgat 660

gtaacatcca ggatttgatg ttttactctc caattctgca aatccagacg caggaggttt 720

taagaggccg ttgcaccctg caataaagtg cgggacacag gaatcttggt cctcggggca 780

cccccttccc tcgggggggt ttcgcccccc gcactcacgg cccctgagcc cgcgcggagg 840

cccgacgccc cgcggccgac gccggtcccc gccccgggcc gccattggct gttgccatgg 900

caccagcccg tcttcccgcg ccctcattgg ctgtctcacc cgcatccctc atcccgcatc 960

ctcccccgct cgcggtggtc tcgcccagcg ctaggagcgg cagcgccgcc tgcccaggcc 1020

cggaccgggc tttgtccgcc ccggagcccc tgcccgcgcc gcggagaccc cggagcccgc 1080

gcgctccgag gccaccccgg gccgggattt ccggtggggc ccgcggagcc gcgcagaggg 1140

aggaggcccc agacccaggc gccccgccag cccagctgca cgtaagcggg tgtgtgtcct 1200

<210>2

<211>1200

<212>DNA

<213>智人

<400>2

aaaactgtca tggttacagc catcaaatta caggaggttc acacacagca gtcagcaatg 60

gtttgggaat attaaataaa tgtgtttctc taacaggaca agacaggatc atttatttat 120

gcaacttaaa agctgtccca gaaggagaaa aaagtagcgt attatttgtc caaaataaac 180

aagattgaag aactgaacat ctctctgtgg atcaatttac agatcacatg gaaataggct 240

tatcttattg agaaatattc cattttagat gttcaaatac cttagcatat tttaaaaact 300

atttcctatg tgaccaaaag aattcatgtt ctattcggta aaaattaacc aaaattaacg 360

gtgctttcca atggacgcag gaaacctttt ttctttacaa aatatgccca cccttttttt 420

gttgctactt cccacattga attcttgttt tactgaattt tcttactata aaaataaagc 480

atgatgatag ttttgaaaac aaaacagaag tatttgagaa gtacagaccc cactcccact 540

ccttgtctcc tttctgacac tctgcccctt aactatactg gaacagggag tcaactgcaa 600

ggaaaatcct ggggactagg ggctgaggaa ctagaggtgg agagatggaa gagtgtccag 660

tagcccagga aaggatgaaa caattcccca acaaaaaagt aaaaattttc agtagccctc 720

cgagaagatg cagcccctcc caggtaacca gagaaaggca aattgtgaaa gcagggagaa 780

ggggctactt taggcctcca ggactacaaa gacaaaaaaa tgagtgacag gacctgatgt 840

ggtggggtga gatgggaatg gaagtaaagg agggggctcg tactcttggt gggagtggaa 900

attggggacc caagcttact ggcgatgcag ccctcacgtg accaggagct gacgtgggca 960

aaggtactta aagccctgac cgtcgttctc cgtcctcctc tgggtaccaa ctctattgcg 1020

cagctcgctg ccgtgcgttt aacccaggcg aggaggagga ggagaaaatt cccccagatt 1080

cgggcaggtg ggtgtgaggg tgggcacagt ctgggacccc tgaatagggt aatctaggga 1140

tgcgggagtc ggaggccgcg ggtgcctcgg tctcccccac tcctggccgg ctttccagac 1200

<210>3

<211>1200

<212>DNA

<213>智人

<400>3

ccagacctga ggtgctcaaa cgcggctcat tttggtgggc ggtggggaaa gggggagggg 60

gaaacgaaaa gacttttgat agactttacg aagaatccgc ttacttcctt tccagccagt 120

gttttttggt tttgtttata atattcaggc ccgcacccca cattccgtcc tgttttgaga 180

ggaggaggga agagaaataa acgtggcagc gcatagaagg ccagcaggga ggttgggaaa 240

gggtaaccag gaggcggggg tggggcatgc aatttggtaa caatctgggc ggcacactcc 300

caccctgact ttccccacca ccgccccggc accctcccat cccccagccg accctctgtg 360

atttgggagt gctgggaaat gggtgtacca gctgctgttg gagaggtggc gggtttggcg 420

ctgtctgggc ttcacgggag gtggggggga aggggcggac cctgagagaa tctggtatta 480

aaccgccttg ttaactcgca gactgctttc cagacacctc cggcccacac agccgttcac 540

cccccgtctt ttcagtcctg gaaaaggaat tcgggtatgc aggcgggaga aatggcggtt 600

gttgggggga tttgtgggaa gtgggaggta gagcccatag cagagaaatc gtggaaaatc 660

tcgaccctga acccgaaaag gcagacgttg aggcccctct tctgcaggct aacgctaggc 720

ctaggggctg gggagcgaaa gatgggtgat cctgggaggg gaacactgaa ttgtttggca 780

ggagtccccc ataccgcgtc ccatccagct tttgctgcac cctcgccccg ctcccctccc 840

gcttcgttgc aggagaaggg gtgtggcggt gtgtcctgga gaaatggcgg acgggggcgg 900

ggcaaagcgg aaggagggat tgagtgcctg gggagcctgc gcaggaggag gattgaggtg 960

ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatcatttg acattctgat 1020

gtgcaaacac gaaaaggcag ttactgagac ccttgtcctg gatgctgatc catccaccag 1080

gctttcattg tctaacgtcg acagtctata tttctgctct tcagtctgtc cttaggatga 1140

agctctaact gaactgaagt aaggagaaac agccttgaat ctttggaggg tcagtgctgg 1200

<210>4

<211>1200

<212>DNA

<213>智人

<400>4

cccagagttg aatcattaac tggaacctaa tccgaagaca ggtgtttaaa actgtcatgg 60

ttacagccat caaattacag gaggttcaca cacagcagtc agcaatggtt tgggaatatt 120

aaataaatgt gtttctctaa caggacaaga caggatcatt tatttatgca acttaaaagc 180

tgtcccagaa ggagaaaaaa gtagcgtatt atttgtccaa aataaacaag attgaagaac 240

tgaacatctc tctgtggatc aatttacaga tcacatggaa ataggcttat cttattgaga 300

aatattccat tttagatgtt caaatacctt agcatatttt aaaaactatt tcctatgtga 360

ccaaaagaat tcatgttcta ttcggtaaaa attaaccaaa attaacggtg ctttccaatg 420

gacgcaggaa accttttttc tttacaaaat atgcccaccc tttttttgtt gctacttccc 480

acattgaatt cttgttttac tgaattttct tactataaaa ataaagcatg atgatagttt 540

tgaaaacaaa acagaagtat ttgagaagta cagaccccac tcccactcct tgtctccttt 600

ctgacactct gccccttaac tatactggaa cagggagtca actgcaagga aaatcctggg 660

gactaggggc tgaggaacta gaggtggaga gatggaagag tgtccagtag cccaggaaag 720

gatgaaacaa ttccccaaca aaaaagtaaa aattttcagt agccctccga gaagatgcag 780

cccctcccag gtaaccagag aaaggcaaat tgtgaaagca gggagaaggg gctactttag 840

gcctccagga ctacaaagac aaaaaaatga gtgacaggac ctgatgtggt ggggtgagat 900

gggaatggaa gtaaaggagg gggctcgtac tcttggtggg agtggaaatt ggggacccaa 960

gcttactggc gatgcagccc tcacgtgacc aggagctgac gtgggcaaag gtacttaaag 1020

ccctgaccgt cgttctccgt cctcctctgg gtaccaactc tattgcgcag ctcgctgccg 1080

tgcgtttaac ccaggcgagg aggaggagga gaaaattccc ccagattcgg gcaggtgggt 1140

gtgagggtgg gcacagtctg ggacccctga atagggtaat ctagggatgc gggagtcgga 1200

<210>5

<211>1200

<212>DNA

<213>智人

<400>5

tgtttaaaac tgtcatggtt acagccatca aattacagga ggttcacaca cagcagtcag 60

caatggtttg ggaatattaa ataaatgtgt ttctctaaca ggacaagaca ggatcattta 120

tttatgcaac ttaaaagctg tcccagaagg agaaaaaagt agcgtattat ttgtccaaaa 180

taaacaagat tgaagaactg aacatctctc tgtggatcaa tttacagatc acatggaaat 240

aggcttatct tattgagaaa tattccattt tagatgttca aataccttag catattttaa 300

aaactatttc ctatgtgacc aaaagaattc atgttctatt cggtaaaaat taaccaaaat 360

taacggtgct ttccaatgga cgcaggaaac cttttttctt tacaaaatat gcccaccctt 420

tttttgttgc tacttcccac attgaattct tgttttactg aattttctta ctataaaaat 480

aaagcatgat gatagttttg aaaacaaaac agaagtattt gagaagtaca gaccccactc 540

ccactccttg tctcctttct gacactctgc cccttaacta tactggaaca gggagtcaac 600

tgcaaggaaa atcctgggga ctaggggctg aggaactaga ggtggagaga tggaagagtg 660

tccagtagcc caggaaagga tgaaacaatt ccccaacaaa aaagtaaaaa ttttcagtag 720

ccctccgaga agatgcagcc cctcccaggt aaccagagaa aggcaaattg tgaaagcagg 780

gagaaggggc tactttaggc ctccaggact acaaagacaa aaaaatgagt gacaggacct 840

gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gctcgtactc ttggtgggag 900

tggaaattgg ggacccaagc ttactggcga tgcagccctc acgtgaccag gagctgacgt 960

gggcaaaggt acttaaagcc ctgaccgtcg ttctccgtcc tcctctgggt accaactcta 1020

ttgcgcagct cgctgccgtg cgtttaaccc aggcgaggag gaggaggaga aaattccccc 1080

agattcgggc aggtgggtgt gagggtgggc acagtctggg acccctgaat agggtaatct 1140

agggatgcgg gagtcggagg ccgcgggtgc ctcggtctcc cccactcctg gccggctttc 1200

<210>6

<211>1200

<212>DNA

<213>智人

<400>6

ttacaggctt gagccaccat gcccggccaa gatgtcagtt ttttaatggt gtgcaacgtc 60

cgtttctttg atagttggaa agcgtggcag gtattagagg gcgaatgtat atttaagaaa 120

aacaagataa gtcttcatct gtagagtatt aatttttctg tgatccttta tctcagacgc 180

ctctcctctg aaggtcactg ctcaagctgg gcagcccctt ctaagaaggg atgctgcctt 240

ggagttggag atgaggttaa gatctacgtg cgggtaccag tttcagtaat aactggatcc 300

ttctctaggt ctaggctgga acgtctcaag tgaaggttat tggggggcag gggtttgggt 360

ccacccaaaa aggcttgacc cataggactg aaatcaaatc ttgagctagg ctggcttgcc 420

acgtaaccac agaaacagta atttaagcaa taaaatgaaa gctcgagcgc tggtccagag 480

ctggggttgg gacagctact gcactcaggt ctccaggtgc atgtagggag aagagcagcg 540

gatcccttgc agacaatggt gggagcgagc tcttcaccct ggggtctccg aagcccattt 600

ttagcgtcca gaggtgtgct ttcgccatct ccttctgcgg tggctgcttg cagggcgcat 660

tcccattgct gctgtctctg ttcctaagga agatcaaagg atcccagaaa acccagttcc 720

agagctcagt tcccgggact agagggtacg ctcggccaga tggctggggg tgccgctggc 780

cttggcgccc ccgccgtccc cgcgcggtcg cccaccccgg cccgacaagc agcttgggcg 840

tccagcccgg cccggtccct gcagggaggg agcgcaggag ctgggggcgg ctctcccggg 900

gcggggctcg ctccacaagc gccaggggcc gcgcggggcg tgggcgtggg cggggccggg 960

ggcggggccg gccttggctg ccgcggcaca ggcggcggcg tctccagggg gagccaaggt 1020

acgtaggcgg cgtccgcctc acccgagcat ccttccccgc cggtggccgc ccgcccgcgg 1080

cccgcgctcg cagcctcccg cctggcggtt gacttctttg tgtcgtattc tctgcctgcg 1140

ccctgtctct gcaggacctg ttcgttcttc tttgggctat aagaaggcag aggatgagat 1200

<210>7

<211>1200

<212>DNA

<213>智人

<400>7

ttctgtgatc ctttatctca gacgcctctc ctctgaaggt cactgctcaa gctgggcagc 60

cccttctaag aagggatgct gccttggagt tggagatgag gttaagatct acgtgcgggt 120

accagtttca gtaataactg gatccttctc taggtctagg ctggaacgtc tcaagtgaag 180

gttattgggg ggcaggggtt tgggtccacc caaaaaggct tgacccatag gactgaaatc 240

aaatcttgag ctaggctggc ttgccacgta accacagaaa cagtaattta agcaataaaa 300

tgaaagctcg agcgctggtc cagagctggg gttgggacag ctactgcact caggtctcca 360

ggtgcatgta gggagaagag cagcggatcc cttgcagaca atggtgggag cgagctcttc 420

accctggggt ctccgaagcc catttttagc gtccagaggt gtgctttcgc catctccttc 480

tgcggtggct gcttgcaggg cgcattccca ttgctgctgt ctctgttcct aaggaagatc 540

aaaggatccc agaaaaccca gttccagagc tcagttcccg ggactagagg gtacgctcgg 600

ccagatggct gggggtgccg ctggccttgg cgcccccgcc gtccccgcgc ggtcgcccac 660

cccggcccga caagcagctt gggcgtccag cccggcccgg tccctgcagg gagggagcgc 720

aggagctggg ggcggctctc ccggggcggg gctcgctcca caagcgccag gggccgcgcg 780

gggcgtgggc gtgggcgggg ccgggggcgg ggccggcctt ggctgccgcg gcacaggcgg 840

cggcgtctcc agggggagcc aaggtacgta ggcggcgtcc gcctcacccg agcatccttc 900

cccgccggtg gccgcccgcc cgcggcccgc gctcgcagcc tcccgcctgg cggttgactt 960

ctttgtgtcg tattctctgc ctgcgccctg tctctgcagg acctgttcgt tcttctttgg 1020

gctataagaa ggcagaggat gagatgtccc gggccacgtc tgttggagac cagctggagg 1080

cacccgcccg caccatttac ctcaaccaac cgcatctcaa caaattccgc gacaaccaga 1140

tcaggtagga gaaggcggcc ggctcgcgcg gaaggcggtg gagtcacagc tgggaagggg 1200

<210>8

<211>1200

<212>DNA

<213>智人

<400>8

ttgtcagtcc ctaatgttaa tttaggttaa aagaaatgta atgctcgcat cagtaaaagc 60

aaggtcagac tttcacctga acagttttat ttttgttttg ttccgttttt actccgaggt 120

cagaatgtca tcaggcacaa taaagatagc ttcttatctt catgggattg tgcccagaaa 180

gaccaagcac agtctaaaca ttacgcgata agaaaaaaca aaaaatagat caagtgacct 240

tggacaagtc atcttacctc tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300

gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtctgt gtgtgtgtgt gtgtgtgtcg 360

atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgctg ttaaggttcc 420

ctagggctac ctgcagcttt aatatgcgta gttagaatgt caggcaggtt gtggagagtg 480

gggggctgga gacccccgac ttctctgagt gccaagccac acatcagaca ccttggaaat 540

aacccttcca cgaagtccct acacagatcc caccaggctg ggcacggaag aacagaaact 600

gcgaaaagaa agggactgga tgagtcctgg ggaatcacag cgcctccact tgcacaggac 660

aagtgacagg caggtaaata ggtagcagac aggcagagac tccgagtccc ccaggtgcac 720

ccctctcctg gaagagcccc cgaaagtaca ggcccaatct cccaccccac caagccctcc 780

ccatcgcctt ccccgacacc taaaagcccc ggtcctgcgt aatattgcgg atccctccca 840

gcctcccgtc cgctcctcct cccgcggggc tccgctcagg gccggtcccc cgcccccacg 900

ccgcagcccg ggccagcggg gcccgccgcg gtggcgttcg cggatgctgc cgcattggcc 960

gctgcggcac ggacggcgca gcctcgggcg cggcccggca caggcgccgg cggtccccgc 1020

cagctagcag cccggcgagg cgctggccca cccatggtcc tcgggcggcg gcccctgcgc 1080

ccagccctgc gcgtagcctc cgtctctcgc ccggggccgc cgagcccccg acacgggcga 1140

gatgctgaac ggcgcaggcc tggacaaagc tcttaagatg tccctgccgc ggaggtcgag 1200

<210>9

<211>1200

<212>DNA

<213>智人

<400>9

gccaaagtga tatattaagg tcaccacctt ggtcacctgt ccatctatat ttttggagta 60

agcaacagaa ttaggagtct gaacatagga attaagaagc tctcgaatat aacagtggaa 120

gaccagcacc ttcccaacct cttgtcaggg cagggatact ctatctctgc gtcactcaac 180

ctgccttggc ctcacagctc ttccttttgc ttaagtcttc aaaccatcaa cagtgatagc 240

cactaatttt agcaggtggc attagttgtc agcaaatgtt ttttcatatt taatgaatgt 300

ttattataat agaataaaat agaaatgttt attaataaaa cttgaaattt gtcccagaag 360

gataaaaacg tagattattt acataaaatg gccaagatct gacaacagaa ctgtttcctg 420

aagatttact tcacagatta ttttgaaaac accaactgtg ttcaggaaaa ttttctctcc 480

tttttttcat aaaattttca aacaagtgag aatgctctaa aaatgatggt gtggagccta 540

gagaaaatgt tttctgtgtg ctatagatga acataaacta tatatatata ttactttccc 600

aggttgaagt gtttctttca aaaataaaat ttgattattt tcaatttttt gagggatgct 660

gatttttaaa aaggaaataa agagaaatta ttaggaagca tatacacagc cagtgagaag 720

aggaaagaag aaaaggccaa ggccagagga agggggtttg gggtggggga aaggaagggt 780

acagaccctc ccaaataacc gaagatgggt aaactccaac cgcaaagcga tgatgccact 840

tgtgggccct cagattggag aggacggaga tgagtgacgg ggctgtgcgc actggggcac 900

cgcgcacaga cgggaggagg ggggtgtctg tgtgttccaa aggggggagt accagttaac 960

tggccgccgg cccgtggggg ttggtgagaa ggagggtgag cttggcggtg acgcacggcc 1020

ctcacgtgac cgggagctgc agagctacgc agccttcggt gcagtcgtca ctcgtgtctc 1080

gctaccagct ccccgctgcc ctgcgctcgg cgggctggca tccggcccgg gggaaagcgg 1140

accaggtaag ggccccgggg cccgcgcgcc ctggctaggc cagcagaggc tcaccgaccc 1200

<210>10

<211>1200

<212>DNA

<213>智人

<400>10

ttgacacttg gatttggatc aacaatgctt tcaagaagaa agacttttga tcaaaagcgg 60

gaaatgagaa agcgactttc ctctgaaaag tgcctcccag tcccgaggct gcgaggcccc 120

cacgccaggc tggctcccac ggaagccggg cacccacccg gcccgaccaa gcgccactcc 180

gccccgtgga cggggcgtcc caccccgggg acgcccgccc cacaccgcgt ttgcaccccg 240

gaggcccctt gccgcagagg cggacggcgc gcctctcccg ggcccctggg gtccgcgcct 300

ccctcgggca gactctttcg actctgctcg agcctccgct tcttcctgcg ggcggacgcc 360

ccggacacaa cgggccccgc tgttcacgca ggggcgcccc ggcggggcgg gcaaagaccc 420

ggggacgcgg tcccgtcccg agacgctcag ctccggccca ccgctcgcag ctcccgcccc 480

gggcgcaggt cccgacccca cgggccgtct cggagccgca gcggccgctt ccctgcacgt 540

cctcacgccc cccgcacgga cgccgccagc cccgcgcctc agtttcccca ctagcaggat 600

ggaaagacgg gccccgcccc gaagcgtagc ggcgtctccg tggtagccag tgcccagaga 660

gtccgccggt cccaccgccc cttcaaagga gaacccggcc caccgcccgc cgcggcggcg 720

accgcgcagc ccactcgtca cgcggcccgc ggcgtccagc ccgggccggc tcacctcagg 780

cggtcgctgc cgccctcgcg cctgcgcgcc cctcgccccg cccctctccc cgcccgcgtc 840

ccgcgcaccg caggcctctg cccctcgccc accgcaggac ccgccccgcg cacgcgccgc 900

acgtgccaca cgcaccccac gcccctgcgc acgcgcaggc cccaagtcgc ggccaatggg 960

cgacgcggcc gcagatccgc ccggccccgc cctgccctgt gagttcctcc ggccgggctg 1020

cggggctccg ctcagtccgg gagcgcagct gggccgcggc gctccgacct ccgctttccc 1080

accgcccgca gctgaagcac atcccgcagc ccggcgcgga ctccgatcgc cgcagttgcc 1140

ctctggcgcc atgtcgcaga acggagcgcc cgggatgcag gaggagagcc tgcagggtga 1200

<210>11

<211>1200

<212>DNA

<213>智人

<400>11

tgctttcaag aagaaagact tttgatcaaa agcgggaaat gagaaagcga ctttcctctg 60

aaaagtgcct cccagtcccg aggctgcgag gcccccacgc caggctggct cccacggaag 120

ccgggcaccc acccggcccg accaagcgcc actccgcccc gtggacgggg cgtcccaccc 180

cggggacgcc cgccccacac cgcgtttgca ccccggaggc cccttgccgc agaggcggac 240

ggcgcgcctc tcccgggccc ctggggtccg cgcctccctc gggcagactc tttcgactct 300

gctcgagcct ccgcttcttc ctgcgggcgg acgccccgga cacaacgggc cccgctgttc 360

acgcaggggc gccccggcgg ggcgggcaaa gacccgggga cgcggtcccg tcccgagacg 420

ctcagctccg gcccaccgct cgcagctccc gccccgggcg caggtcccga ccccacgggc 480

cgtctcggag ccgcagcggc cgcttccctg cacgtcctca cgccccccgc acggacgccg 540

ccagccccgc gcctcagttt ccccactagc aggatggaaa gacgggcccc gccccgaagc 600

gtagcggcgt ctccgtggta gccagtgccc agagagtccg ccggtcccac cgccccttca 660

aaggagaacc cggcccaccg cccgccgcgg cggcgaccgc gcagcccact cgtcacgcgg 720

cccgcggcgt ccagcccggg ccggctcacc tcaggcggtc gctgccgccc tcgcgcctgc 780

gcgcccctcg ccccgcccct ctccccgccc gcgtcccgcg caccgcaggc ctctgcccct 840

cgcccaccgc aggacccgcc ccgcgcacgc gccgcacgtg ccacacgcac cccacgcccc 900

tgcgcacgcg caggccccaa gtcgcggcca atgggcgacg cggccgcaga tccgcccggc 960

cccgccctgc cctgtgagtt cctccggccg ggctgcgggg ctccgctcag tccgggagcg 1020

cagctgggcc gcggcgctcc gacctccgct ttcccaccgc ccgcagctga agcacatccc 1080

gcagcccggc gcggactccg atcgccgcag ttgccctctg gcgccatgtc gcagaacgga 1140

gcgcccggga tgcaggagga gagcctgcag ggtgaggcgg aggaggcggc gcgggagccg 1200

<210>12

<211>1200

<212>DNA

<213>智人

<400>12

ccaacaattt gagcggccaa gacaggcagc tcacttgaag tcagaagttc aagcctggcc 60

aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgtggta gcgggcgcct 120

gtaatcccag ctactcggga ggctgagaca aggagaatcg cttgaatccg gaaggcggag 180

gttgcagtga gccgagatcg cgccactgca ctccagcccg ggcgacagtg cgagactccg 240

tctcaaaaat aaaaataatt agtaaattaa ttcattaatt taagaaaaaa agcgcaatct 300

tcttccaaag gcgatcccaa ggctgttgga ggctgaaacc gctaagtcgc cccctaccgc 360

gcgggtggct tcgtcccgga cccctccaga ggctgtgcca ctgctggagg tgctcagcgg 420

ggccgggacc cgcttggggc gccgtccggg gcgagcaccg gagcccgact gggctgaatg 480

gcaggtcctg accaagccac ccgcgcggcc ccgcccgcct ggcgggatga gtgacggcgg 540

caacaggtgc agagcggcgt ccgcggcttc tcgggagccc ccgagttttg cgagtcaggc 600

cccgagagtc agagtttgac tctagaacct tcttcgcttt acaccagtct tcggaagtcg 660

cccgtcaacc ggcttcttct acctcagtaa agccttaagg tcacctcaac ctctcgaaac 720

ccaccagtcc cagaggccga ctcttctcaa gtggaggaga ggggaaggcg tgcatggagc 780

tttgcctgac cgctcgctct ctcctcccca gccgtctgag agaaggcgag aggggtccca 840

gaaccgagcc ctcgctccgc acgccccacg cccgccccgc tgtgccgtgc gctctgcccc 900

tgagacgccc cggctcggag tcccagggcc acagccgaaa ctcgccctcc cgcgcccctc 960

tccggcttgc agcgcccgcc cgcaccgcca cctgccaccc gaggcgacgc agtccgcttc 1020

tccccacccg ccaggtggca ggttcagggc cggggtccga gcctgcttcc ctgcagctgc 1080

cacagccacc ctcgccgcca gggggcgaga gtcccaggca ggacaagcag cgctgctgcc 1140

ttggcgtgaa ggtggtttca aactttaggc ttcttttccc taccccgcgt ctctgaagag 1200

<210>13

<211>1200

<212>DNA

<213>智人

<400>13

gaggaagatg gaaaccgagt ccgggccggt gagtacggcg atcagggccc cagggcgcgg 60

gatagcgggg agaaggagca gcgtggagcc tgtccctgag ggcttggagg ggcgaggtga 120

aggccccaaa cgctcgctat ctggttggga agaaacgtgg ccaggtgccc catcgaccgc 180

tgccaggagc cacccgcccg cagacctcgt ctggctgtgt catgggggtc agaaaggcgc 240

cgccacgggg cctggactgg gtgtagacgg gccaggggac ctcaggcgtg gatgtttcgg 300

gaggcggcgg gctgccaggc acccagcgaa gtccgagcag gtaaaccgct ttcccgccga 360

aattgggcta ggcagcgtct ttgacgctcc ctgcggccga actcgaccca gccgcccaag 420

gcgaggagtt gccagggcgg tcgacgcctc cactccccga ctggtcagcg aggaccggaa 480

ggtctgagag acctggcagg gcccgcctgt ggcccaggcg ggacccggac actctagccc 540

tggctgtgca cccaagccag tcagggtgga cttggggaag tgaaggagga ctgcccgcac 600

aggcccgagg cgcagcggca acgtgccatc ccgccccgcc ccgtcccgcc gccagcagcc 660

aatcagggag cgccgcgcga gggtggggac cagctgcgca cgaggccagc ggcggggtcg 720

ctgccgttga ggcttcccgc cactgctgct ggcggatttg tggggcaaaa tttctcgctg 780

gctagccttc ttttccctcc cgcactttgg tggggagggg gtggatcctc gtttcggtgc 840

ccaagttcac gatgacccga gagaactcga ggaagttgtc gccgcggcca tttcccccag 900

tgccgcaact tgctggcctt ggagggggag gagcgccgag gcagtgactg cgacggttag 960

cccgcccgtt cctgctgtct tcgtttgcaa aatagatgct agatctcgag gttgattctc 1020

aaggggaggg gccagtgagg gcacattgct ttggaggagt agtttaataa actctctagt 1080

gctggaagtt ttagcaaacg gaggagcctt caaacccggc aacagtcccc atctaggtgt 1140

ttccgtaaca catgcggaat tattgctagt ggaatttcag gctttctttg ttgtttaact 1200

<210>14

<211>1200

<212>DNA

<213>智人

<400>14

ggattttgta tatgtcatca gctgttgtga ccttccaacc catgagaatt ttcctcatgc 60

ctgaggattc acttaaggct acactttcag atccagagat atctttcttt tcctcttggc 120

tgggtcagtc tgactttggc tgcatgatca cacattatta gcaggtgcta ccatttttag 180

gttagaatat gtgactttct taaagtaaaa aaaatcctat agtcctctag cttatcaatt 240

cattaagtta aactttatat accaattttc ttaaatggag gaatgccttt attaatatgc 300

agcatctatg tcattactaa attactatac caacaaagat gaaataattt attgcccaag 360

ttggtctccc ccccacccaa cctttttccc cagttttgtg tggaagtttg atcaggagct 420

ttttccatgg aggttttcag cttccttagt tctaggcaca aagttatgat ctttccctga 480

tgctgaccac cttaggatga tatctgatta ttagtcttgc tactgcgcta ttaagtgtca 540

cttatttcta aggaaatgaa ttgagggtct tggacaggat aaggacagga atgttttatt 600

acccacacta cagatgttgg aaaacaaagc tgaaaactct tttaatttgt gtctatactg 660

acatctgaat gcttaaccca ttattgcttt tttttttggt ggtggtgggt agagatgggg 720

tctcactgtt gcccaggctg gtcttgaact cctgggctca agcgatcctc ctgcctcagc 780

cttccaaagt cctgggatta caggcatgag ccactacatc cctattattg ccttctttaa 840

aaatcttttc ttctctaaaa atctttttag atgttaatta acccatctgg ttgttgtttt 900

tcagtagaga aatggtcaga aggaacgaca ccacagaaga aattagaatg tttaaaagaa 960

ccaggaaaaa catctgtaga atctaaagta cctacccaga tggaaaaatc tacagacaca 1020

gacgaggaca atgtaaccag aacagaatat agtgacaaaa ccacccagtt tccatcagtt 1080

tatgctgtgc caggcactga gcaaacggaa gcagttggtg gtctttcttc caaaccagcc 1140

acccctaaga ctactacccc accctcatca ccacctccaa cagctgtctc accagagttt 1200

<210>15

<211>1200

<212>DNA

<213>智人

<400>15

taaggctgct tgtactctga taatcatgat tatggtgtta tttagagccc agcccaaata 60

cctgagccta aatgagtgaa agagcagaga gtgggcgttt ttttgttttt tttgttttgt 120

tttttgtttt tttgagacgg agtctcgctc agtagcccag gctggagtgc agtggtgtga 180

tctgggctca ctgcaacctc cgcctcccag gttcaagcaa ttctctgcct caacctccag 240

agtagctggg attacaggca cccaccacca cgaccggcta atattttgta tttttagtag 300

agacagggtt tcaccatctt ggccaggctg gtcttgaact cctgacctcg tgatccaccc 360

gcctcggcct ccgaaagtgc tgggattaca ggcgtgagcc accgtgcccg gcagagtggg 420

cgtttttaaa tgaagcagta ttcctttagt ttggtaaaat tgagctgaag ttacacacag 480

taacaccttg acttgttgct gacggtgtgc tttgtgggga tagttggtgt ctgatctcaa 540

ctgtggagaa acaggaagtt tctggattca tgctgaactc ccattccaca ggcgagtttc 600

acaaaagaaa aagtgctctg ttgcatacaa ttattcactg tgtgtctaca acgtggcaga 660

aattattatt cctaaaggtg accgaagaga gctatagttt atggggccag gagcaatgtg 720

tggaatggcg aggcagtgac aagacagcac tgccataaat ctcttacttt ctttccaaac 780

gagctctaat tttaagctca acgaccaaag acggagaggc agtcgctttg agctactcct 840

ggctatttgt tgggaaatca cctaaatccg ttcagattta gccagaaaag gggaaataag 900

tctccctcgc cggccaaatc atggcctttg tcgctttcgg ctccccattg gctgcggccg 960

ctgtggcccc gcctccttga gtggtgcgga gctttgtgat gcggagcttc gtgatgcacg 1020

ccccgatgcc tgcggggcta taaaaacgct cgcaagcgcc aagtctcctc aggagccgcc 1080

ggcaaggggg caacgaggaa gctcttaaga gcgcggccgg aaagcaggtg gggagaatct 1140

ggagaaaagg cgcaccctgc ggcctcggag accattatgt ctcagggagt ctctcgcagt 1200

<210>16

<211>1200

<212>DNA

<213>智人

<400>16

tggaaaatca gacaccagac ccctcacctg caacaattgc ctgatgcctg ttgacccact 60

cctcttcatc tctccctaac tcctgctatt ttcccacatg cagttacatt tcttccctgc 120

tatatcctaa ttttaatcag ttgagaagat ggatttgaga ctgatctctc ccccctaggc 180

tgtagcaccc aaataatgcc ttcttccctg acaataatgg ggtctcagtg actggctttc 240

tgtgctgtga accaccagac ctagaccaaa ctcctggcat ttctctaaca atttcccacc 300

actgaactaa gttataaatt ctgaggatgg atccctgttt cttcatttta agatggggat 360

taaaaggtac atcctagagt gttattgtcc gtgtaaaata gggctgtgaa accccctaca 420

cctatgcaca gataaactga tggccctgca aatgcccaga gaagtaacct tataaagatt 480

tagtgaatgt ttcccaccat tattggaaaa tctggctaag tcagtagctt tgttttcata 540

tacttagggg gaaaatcaac aaaaacttga tgccctgtta tttccttcca gtttcttctg 600

caactctagc tccaaagact gcagttcctg cagtattttt ttttttagaa caccaggaaa 660

aaaagaaaaa aaaaccatgc aaatgtacta tttcttcaaa cacaactagg aatgattgaa 720

cagctgggag aatatgaaga aaacccctca gagaaccaag ggcaagcagt gagttcagat 780

ctaggcacat ggccactagg aatggttctt cactgccacg tgggcagcca acagccagta 840

gctagagacc agcctcggtc ttcggcctgc gggttctgca aagtcaggct agctggctct 900

ccgcctgctc cgcaccccgg cgaggttccg gtggggaggg gtagggatgg ttcagccccg 960

ccccgctagg gcggggcctg cgcctgcgcg ctcagcggcc gggcgtgtaa cccacgggtg 1020

cgcgcccacg accgccagac tcgagcagtc tctggaacac gctgcggggc tcccgggcct 1080

gagccaggtc tgttctccac gcaggtgttc cgcgcgcccc gttcagccat gtcgtccggc 1140

atccatgtag cgctggtgac tggaggcaac aagggcatcg gcttggccat cgtgcgcgac 1200

<210>17

<211>1200

<212>DNA

<213>智人

<400>17

actcaagcac cagcaagcgg actcgaactc aaagggtttc agggtgtaga cgaccagagc 60

gcactgaggg gctccaggtc ggcccgctcc ggagccggga gagtaaccgc gtgcagggaa 120

aggcgcacgg cagcctcggt gcctcccttc cctccaccgg acgggtgact gactaggggt 180

gaggtcctca cctccaggct gcgcagctga gttctggaag gtactgtcct gggggtgtga 240

gtgtgtgggc cctcaggaaa ggtgcgaggg gcggatgccg tggtctaccc gagcttgcgg 300

gggtgcggtg gtcaagttcc ccaggaccct cgctggcgcc gcttgtcgac aacggggaac 360

agtgggcgcc gcgggtggtg gtaacttggc ccgggaagaa aacacatccc tttcccaaac 420

cggattcctc tgagcaaaac cagatggtgt catccgcatt ttacagctgc gtcaagagag 480

gcccaggaca ccaagagcca gctgtggcca gagccctttc actgacccag aacactggcc 540

ctcggaaacc tggagaactg cgagggcttt taatgcggct gagaagaaag tgaagacccc 600

gactcctcct ctctccttcg aaagagccga cacaggtatg aagaccagcg cctcggacgc 660

tccggggtag ggggccgacg ccccctccct ttcagaatca cgccttgctg atgctcagtc 720

ctgcccagtg tccacccccc acccccgccc ccagtttcct ttctagcccc tccggtcccc 780

aaagcgaact aagctagcgg cagcttctcc atcccggagg agactccaaa ctcctaggtt 840

tcccaccttg gagagtactg ctctggaatg cgcaggggag cggcacctgg aaagggttgg 900

gcggaagctt ctcggaccca gagggggcgg acacccggca ccgcgcgtgg gagggattaa 960

ctccacccca ctagaccacc tccccctctc tcccaggagc cacttcaacc ggttgtcgcc 1020

ccagtggccg ccctctgagc acgtgttact gccagtctgc gtcagcgttg ggtaaataca 1080

tgactggccg acgccgccgg gtggggctat ttaagagaca gccgcccgct ggtcctccct 1140

gaacttggct cagctgccgg gctgctccgg ttggaaacgc caagccagct gcgtcctaat 1200

<210>18

<211>1200

<212>DNA

<213>智人

<400>18

cctcttttcc gtttgcattt tgccccatat tagaatgcta ccatctaaaa ccgctccatg 60

aattagaaag tttaagttgt cagggactga atgtgtctgt tttccaacag tttctggcag 120

ttccctgctt ttatggtgta gtcatggtga aacctgagtc atctgaagat ggtggcagtg 180

ccagagagca ggagagagga gctgcaaaga agccagacag cgttgggcat caataactcc 240

tgggcaccac cggccactgg ccttcattct gacaggagag ccaacccaac cctaactgtg 300

ttcagagatt gctccaagct ttacagttct accaaattct ttctgtagca aaaatataaa 360

ggcatcttct taggtaattt tttttcaggg ttccaagtag caacacctaa cgtctgcagt 420

gcgagttctc ttcttctttt tttttttaag gtgataaatc ataacatttt cctggaaagg 480

aaagcagtag acctcatttt ttgttttaag gaaaaatagt ttttctgttt ccattcatat 540

acattaaata actacccagg aaatacgccc cggttttgcg cgcgtgtgcg tgcgtgtgtg 600

tgtgcgtgtg tgtgtgtgcc gtttctctaa aattctgact catagtctgg aggacaatga 660

ttgacttttt tccacttcac atagttgcta tgaatttctc ctcacaagga tgggcctgtt 720

tactcaccct gggcatcgtt ggtagagcgc tagtgtaaac agcctgagga acccggtggg 780

ccggggaagt gggcgcgctc tgttctccgc ggccagctgg gacgccgggc caggtggggc 840

cgcctgcgtt tagcaactgc tttctcaccc cctggatttg cgatgtttgc cacagcagcg 900

agaagcgcca ttgtaatggg gatgggaggg gtggagcctc caagtcctgt ctcaatttag 960

atctctcact ctgctgttag gcgcgcccat ttcagattac taaactcgaa ttaagaggga 1020

aaaaaaatca gggaggaggt ggcaagccac accccacggt gcccgcgaac ttccccggca 1080

gcggactgta gcccaggcag acgccgtcga gatgcagggc ccaccgctcc tgaccgccgc 1140

ccacctcctc tgcgtgtgca ccgccgcgct ggccgtggct cccgggtagg aacgtgggcg 1200

<210>19

<211>1200

<212>DNA

<213>智人

<400>19

atgcgtgctg aagtatgtag gggtaaaatg acatgatgtc tggaatttgt tttaaaatac 60

ttcagaaaag cggggagtag gtgaaataag tgtgacaaaa ccttaatagt tgttgaagcg 120

gggtgatggg tacacagcag ttcattatac aattctactt ttgtgtatgc ttgaaacctc 180

tcaattaaaa aaagagggta gagagtcatc aagataattt actaaaagtt tcctgtaatg 240

tccccagaag acccccctaa ctcacacaca cacacaccca cacacacact gccttttgag 300

aactttctct agaaggccaa cccaggcagt cccccaactg taaggaagac tcgtgtatgt 360

atgtgcatat gtgcatttcc ccagggaaaa acatccacag cttccatgac gagaggggtc 420

gtgacccctc cccgccaaaa gattaaggac ctgcgatcct acagaccgga gccctgtttg 480

aagtctgcgt tgcccctcac ctcaagctgg tcactgtgtg aagttggcct agaatccccc 540

ggcccctggg agcttgttcc tccgcctgta aaatggggct gcagggccgt ccacgcggcc 600

accggaagga caaggtgttc aggccgctag gccgctccct ggcaagcgat tcccactcgc 660

agcgcggcct cgaccctcgc ccaagacgcg ccctccgcgc ccccaccccc tccaggccct 720

ggccagtcca cctcccgctt ggggcggcaa tttgtctcct tttgaacccc ccgcccccga 780

cgggtttccc cctttgattc gcggcccgga ggcttccccc cgctttgaaa tgcaaacccg 840

cctcggctgg ggccgcgggc ggcccggagc tataaaaggc ctgggtgggg cgggcgcggc 900

ggcaggacag ccgagttcag gtgagcggtt gctcgtcgtc ggggcggccg gcagcggcgg 960

ctccagggcc cagcatgcgc gggggacccc gcggccacca tgtatgtggg ctatgtgctg 1020

gacaaggatt cgcccgtgta ccccggccca gccaggccag ccagcctcgg cctgggcccg 1080

caagcctacg gccccccggc cccgcccccg gcgcccccgc agtaccccga cttctccagc 1140

tactctcacg tggagccggc ccccgcgccc ccgacggcct ggggggcgcc cttccctgcg 1200

<210>20

<211>1200

<212>DNA

<213>智人

<400>20

aggcgctcat ttaaaattcc agtcttgctc ccgagggctt tggcctccat cttcaccttt 60

aacgaccgag ggctggtggc ggcggctcct tcctgctctg cgacaggtgt cgcttctgag 120

cgggagtttt gggcacagac atcgcagatc cgcaccaccc ctaggggtct gcatgggttt 180

cagctgcacc cagcctggag gggctttttg gaagggggca cgtgggcggt gggagcgggg 240

aagcaggtga ggggagcccg cctgcgcgga tttttctgct gtaaatcaga cccacagtct 300

ccagagcgtc ttttccccaa gtgtggaaca catttttctt ctaatcctct ttggagaggg 360

ggttaggaac gtgccgaggc cggagccggg agcggggtgg gtcccggcgc ctgtgaaccg 420

agtgggggag cgggccgcgc gctgccctga agaccctgcc tccgcgccct tgggggctcg 480

gggcccagcg ccttcgcagg cgagcggcgg cggctggctc tgcccggggt gcgcgggggc 540

ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc cccgactgcc cgctcggccg 600

tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct gccggggcgc cccccggtcc 660

ccaccctcac ccggcggctc aggactagtc ccccaacttg ttctctgctg ttaactagtc 720

gcgctgccgg aacgatggga tggggttgcc acagcaacca gactggacgt cacaatccgg 780

gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg cgctgccgcc gccaccctcg 840

gccggctgcg ggactcgggc tgcggggcgc ggtgggagga gcgcccgggc tttgcgggga 900

gcaggctaag gcggccgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960

tgggggggca ggcggccgcc atcttctcgc cgaggccgcc tcgcccgccg cgcgcgccgg 1020

tccggcagcg cacgggttaa ggctggcacc gcgcccggcg ggaggggggg cgcccacctc 1080

ccctcctccc cgcgccgggc atgcggggcc cagtgggcac cgaggaggag ctgccgcggc 1140

tgttcgccga ggagatggag aatgaggacg agatgtcagg tgagcggggc gcgggtgcgc 1200

<210>21

<211>1200

<212>DNA

<213>智人

<400>21

cctctcggcc tttgctgtca ccaaggccaa aggaaggctg gctgtgtggt gtaccttgca 60

cctccagaat gccttcaggt gtgatgtggc accacagatc tggtaggtgg aggaaggggt 120

gggccatttt acagatggga aagcaggctc tggaggcttg gatgagtttc cgaggacagg 180

tagtagcaaa gctgggacct gctatcccca ccagagctgt ctccctgaat cagtcacccc 240

cgaccctgtc cagtcagaca gcaccgcctc cttggagggc caaggctgct cccacccatc 300

tcagggcccg agtggtgtgg tttgtggctg ttgtatttct tgcctttgcc agccagcagc 360

tcactgtcac cctagcatct gtcagggccc ctgcagtgtg tctgtgggct gccagagatg 420

gggcctcatt gtcccagcct agacgcacgg tgcctgggtg cagccctgcc ccgggtgagg 480

gatggtggat ggggctgccg tgtccctggg ctccagcaca gggctcatgc tccctgagtg 540

cttggggatc acacagtgat gtgacctctt ttcagggggc aatgggaaga cctaaggtag 600

gggaagtcca gaatctcatg ttctgctccc tgctctgctg tcccttgccg agtgggcctc 660

agtttccccc tctgtcctat gcacatggca gtctcaccta cgctggctca gatattctgg 720

gtgccgataa gttcaccatt gagtgaaagg gccacgtggt ctcacagacc cccactgccc 780

atctcctgtg tgcatgaccc atgcggctcc tggggacggg gtggatgtca tggcgtcacc 840

gtggtactgt tctgacttgg gggcagtggc actgatggga gggagcctgc atggcagcct 900

gctgtcatgg gagcctcagg gtggggccct gcagctgagc cccaccttgg ggacccttct 960

ctgtccacag tgccccccac tgaagggcaa agtccagcgg attctacact ggaggtggac 1020

ggagccccct gcccccttca tggtggggct gccggggcct gacgtggagc ccagcctccc 1080

tccacctaag cccctggagg gcatccctga gagagagttc tttgtcaagt gggcagggct 1140

gtcctactgg cattgctcct gggtgaagga gctacaggtg agtgcccggg agggtggctg 1200

<210>22

<211>1200

<212>DNA

<213>智人

<400>22

cgacaggtgt cgcttctgag cgggagtttt gggcacagac atcgcagatc cgcaccaccc 60

ctaggggtct gcatgggttt cagctgcacc cagcctggag gggctttttg gaagggggca 120

cgtgggcggt gggagcgggg aagcaggtga ggggagcccg cctgcgcgga tttttctgct 180

gtaaatcaga cccacagtct ccagagcgtc ttttccccaa gtgtggaaca catttttctt 240

ctaatcctct ttggagaggg ggttaggaac gtgccgaggc cggagccggg agcggggtgg 300

gtcccggcgc ctgtgaaccg agtgggggag cgggccgcgc gctgccctga agaccctgcc 360

tccgcgccct tgggggctcg gggcccagcg ccttcgcagg cgagcggcgg cggctggctc 420

tgcccggggt gcgcgggggc ggtgtttcct cgcctccccc tgcgcccggg ctcgccaagc 480

cccgactgcc cgctcggccg tcgggtccgc gggcgcgcgg acgcctcgac ggctccccct 540

gccggggcgc cccccggtcc ccaccctcac ccggcggctc aggactagtc ccccaacttg 600

ttctctgctg ttaactagtc gcgctgccgg aacgatggga tggggttgcc acagcaacca 660

gactggacgt cacaatccgg gcatgtgtgc cgcccccccg ccgtgccgcc gtgcctctgg 720

cgctgccgcc gccaccctcg gccggctgcg ggactcgggc tgcggggcgc ggtgggagga 780

gcgcccgggc tttgcgggga gcaggctaag gcggccgaga gaaagggggg tcgagacggg 840

ggggtggagg tttggggggg tgggggggca ggcggccgcc atcttctcgc cgaggccgcc 900

tcgcccgccg cgcgcgccgg tccggcagcg cacgggttaa ggctggcacc gcgcccggcg 960

ggaggggggg cgcccacctc ccctcctccc cgcgccgggc atgcggggcc cagtgggcac 1020

cgaggaggag ctgccgcggc tgttcgccga ggagatggag aatgaggacg agatgtcagg 1080

tgagcggggc gcgggtgcgc ctggggccag agcggcgggg gcgccgagac gggccgggcc 1140

cagggcggag cgcgggcggc gggggcggcg cggccgggct ggcgcctcgc aggaggggca 1200

<210>23

<211>1200

<212>DNA

<213>智人

<400>23

gcatgaaatt gagataaaac atttcaacag actggacaga ctctgaacac tgttgaagag 60

aacattgata aattggaacc tggtgctgag gcattttccc agaatgcaat gtacagagac 120

aaagataaaa cagggagaac atggaagaca ccttgagatg ctccaacaat catccaattg 180

gagttgcaga agaaacagaa aaaatggtga agaagttgga tttgttgaga gtttgcagac 240

ctggagagaa atgtgaggtc tcagatctgg agtgcattct ggaatagcaa gcaagataaa 300

tataaataaa tgaacccgta gacacgttag aacctctagg tactttagac ctagtaccta 360

caaaataagg gcagccagat cgttctcaga cttcttaaca acaacaggtg gcagagacca 420

tggcaaaatc tccggtgcac tgagggaaaa tgtgtgctga tagttttata tccagctaaa 480

ctctctctcg agaataaagg gaattatacg gggtcatggg agctcagaag ggactgcctt 540

tcttttctta tggggaggag tgaaatcagg gaagacatca cagaggtgat gtttatgttc 600

cctaggcagt aagggggtgg gcattccagg aagagagtca ggtagtttgg aatggctggg 660

ggctgtgaag gagcactcgt cctgcagcgc cttgaataca gggcagtgag atggaactta 720

attctgtgtg gtgggagcag gggaggctca tgtcagagcc ctgatttagg taagtggctg 780

tggggctagg caggaggatg gattggctcc aaggggtgag gttggaagct ttgttcttcc 840

ccagagtcct gcattgggcc tgcctgggtc ccagctgtct ccccacctag caggcagctc 900

tctcctcccc tgcctgtggc ggggtccccg cccatggccc atggggcccc ttgctccttg 960

gcagttcctc acgtgcccgt ctcccctgca gatgaccaag atgctggacc tcctggagga 1020

cttcctggag tacgaaggct acaagtatga gcggattgat ggtggcatca ccgggggcct 1080

ccggcaggag gcaatcgaca gattcaatgg tacccccatc ctgcccaagg gttctgattg 1140

agactccttt ttggcctctt ctcccaggcc tggttcttag ccaggtcacc cagctggtgt 1200

<210>24

<211>1200

<212>DNA

<213>智人

<400>24

gaaatctacc tatttgtaac tccagggaag taaatgagat aatgtttgga agatatctag 60

tctaccagct gctcaggcgg ggggcgaagg ttctgttccc tgtcccttct ctatcaaatg 120

gctttaaaat cagaagaaag tattacgggt aggaaatggg actgcgaaaa aaatggaggc 180

tgattctggc ctaaaggata cttatctcta tacaaagggc ttctgattca aagaggcccc 240

gggattcaaa aacacaagca gagctacacc acgtggggtt tgggacgagc tgaattccgg 300

ataaagatgc ctgtaaagag gagttgatgc gaatccagaa aagcacttga aatgcccagg 360

ctttgcatgg cacattcccc aggatttttt cgcaccgcat ttagaggttt agacggagtg 420

agctcgaatc aggccaaaag ccttaggtta ctcctgggcg gcagcggggc agaggtcaga 480

tcaacaggtg tggaaggctg cgaggtgagg gaagaagcag gtgtcggtgg aggccccagt 540

tcctccggcc cagaggctcc aacgctgcta ttggtgttcc agcagcgggc ggaggggtcc 600

tgcccggcat ctgggcgcgc tgggcccaga gcccgggagg aggcagacgg aggcggcggg 660

tcagcggcgg gccagccccg gtgggcttcc gctcccctcc gccggcccgg tccggcccgc 720

cgcggaggat gcctggaggt tgacgtgaat ggcctgtggc tgggaagccc ccaggcgccc 780

tgcctagccc gggggcgggg ccgcctagcc gccggccccg gtggcgtgag ggctggggcg 840

ggggccgggg acctcgcggg gagggagcgg gagggaaagc ggcccccgcg gcccttcaat 900

tggccgcacc gcccctcggc gcagaggcgg gaggaggcgg ccctccattg gtcgggcccg 960

gcggccaatc ctcgaaggcc caggcggagg cgggggcggc ctgtggggaa ccgaggtgcg 1020

ggcggcgagc gaggcagccg ggtgcttcgc agcggagctc gaggctctgt agcacccagt 1080

tggacccagt cgcccaggca ccgcccgcgc cccgcggccg tctcctgcgc ctcccagagg 1140

agggagttcg agcatccccc gcggcggcca ctcctcgggg ccaggagcgg ggaagcgaag 1200

<210>25

<211>1200

<212>DNA

<213>智人

<400>25

gatctcaggg attgaaatct gtcctaggtg tgcaccagaa agtggtggca agagatgaag 60

cttcggagga ggctgacctc ggccaggatt cttaagtctc aaagtttcag ctttctcacc 120

cctcaacgga catgaaatct acctatttgt aactccaggg aagtaaatga gataatgttt 180

ggaagatatc tagtctacca gctgctcagg cggggggcga aggttctgtt ccctgtccct 240

tctctatcaa atggctttaa aatcagaaga aagtattacg ggtaggaaat gggactgcga 300

aaaaaatgga ggctgattct ggcctaaagg atacttatct ctatacaaag ggcttctgat 360

tcaaagaggc cccgggattc aaaaacacaa gcagagctac accacgtggg gtttgggacg 420

agctgaattc cggataaaga tgcctgtaaa gaggagttga tgcgaatcca gaaaagcact 480

tgaaatgccc aggctttgca tggcacattc cccaggattt tttcgcaccg catttagagg 540

tttagacgga gtgagctcga atcaggccaa aagccttagg ttactcctgg gcggcagcgg 600

ggcagaggtc agatcaacag gtgtggaagg ctgcgaggtg agggaagaag caggtgtcgg 660

tggaggcccc agttcctccg gcccagaggc tccaacgctg ctattggtgt tccagcagcg 720

ggcggagggg tcctgcccgg catctgggcg cgctgggccc agagcccggg aggaggcaga 780

cggaggcggc gggtcagcgg cgggccagcc ccggtgggct tccgctcccc tccgccggcc 840

cggtccggcc cgccgcggag gatgcctgga ggttgacgtg aatggcctgt ggctgggaag 900

cccccaggcg ccctgcctag cccgggggcg gggccgccta gccgccggcc ccggtggcgt 960

gagggctggg gcgggggccg gggacctcgc ggggagggag cgggagggaa agcggccccc 1020

gcggcccttc aattggccgc accgcccctc ggcgcagagg cgggaggagg cggccctcca 1080

ttggtcgggc ccggcggcca atcctcgaag gcccaggcgg aggcgggggc ggcctgtggg 1140

gaaccgaggt gcgggcggcg agcgaggcag ccgggtgctt cgcagcggag ctcgaggctc 1200

<210>26

<211>1200

<212>DNA

<213>智人

<400>26

gggatggagt attgcagcct ctcgccccac agacttgtga acagggcgtg gggacagaca 60

cccagctcct agggccatgc cacccccacc cctgcccgcc tctcgcagca cctttcctgt 120

ggatctgacc cccttccaga cacagaagta agccagcacc cagcagacac agggtcacct 180

cccagctccc taccaggcaa gagcgaccag ggcagggact gatactgccg aacccaggag 240

ccaggcccga cccagcctca ggtccagcag gtcccgcctg tccacctggg ccaggcctag 300

agcccgggag cccctggctg gtgggaggcc acccgcaacc caccccacac gcagctccag 360

ctcccccacc aggcggggcg actaggacag ggacagaacc cgttgaaccc aggagtgaga 420

tccggccccg ggtcccgctg ggccctcccg tccaccttgg ctggacctgg cgcctgggag 480

accttggctg gcgcgaggcc acgcccacca gacatgcagt tccagctacc ccaccagctg 540

ggcgaccagg acagggacgg aggctgctga gcccagttag aggcctgccc cccggggtct 600

gtcctgggcg ctcccccaag gacggacagg gcaggcaggg tccgggacga tggccgcaca 660

gtcccggccc cgtgttccca ggcccgtctt gctcctcgat gtgagggaga cccgggggat 720

gggacaggct gggccccgca gtgcctgact ccctgcaggg ctcccgggac aggggtccgg 780

cggacagccg gctgctcacg ggtgaggggt ccaagctggc attgcggcca ccttccggcc 840

cgggctctct tggggagggg cggggttggt gagaaccggt cacgtgctcc ggggctcact 900

cggggtctcc cagggccgga agtagggccc ctgtgcgcag gcgccctgag gatcccgggc 960

tgcccatctc acgccagggg gcggaacttc ctgcagcctc tctgcctccg catcctcgtg 1020

ggccctgacc ttctctctga gagccgggca gaggctccgg agccatgcag gccgaaggcc 1080

agggcacagg gggttcgacg ggcgatgctg atggcccagg aggccctggc attcctgatg 1140

gcccaggggg caatgctggc ggcccaggag aggcgggtgc cacgggcggc agaggtcccc 1200

<210>27

<211>1200

<212>DNA

<213>智人

<400>27

ttgcagcctc tcgccccaca gacttgtgaa cagggcgtgg ggacagacac ccagctccta 60

gggccatgcc acccccaccc ctgcccgcct ctcgcagcac ctttcctgtg gatctgaccc 120

ccttccagac acagaagtaa gccagcaccc agcagacaca gggtcacctc ccagctccct 180

accaggcaag agcgaccagg gcagggactg atactgccga acccaggagc caggcccgac 240

ccagcctcag gtccagcagg tcccgcctgt ccacctgggc caggcctaga gcccgggagc 300

ccctggctgg tgggaggcca cccgcaaccc accccacacg cagctccagc tcccccacca 360

ggcggggcga ctaggacagg gacagaaccc gttgaaccca ggagtgagat ccggccccgg 420

gtcccgctgg gccctcccgt ccaccttggc tggacctggc gcctgggaga ccttggctgg 480

cgcgaggcca cgcccaccag acatgcagtt ccagctaccc caccagctgg gcgaccagga 540

cagggacgga ggctgctgag cccagttaga ggcctgcccc ccggggtctg tcctgggcgc 600

tcccccaagg acggacaggg caggcagggt ccgggacgat ggccgcacag tcccggcccc 660

gtgttcccag gcccgtcttg ctcctcgatg tgagggagac ccgggggatg ggacaggctg 720

ggccccgcag tgcctgactc cctgcagggc tcccgggaca ggggtccggc ggacagccgg 780

ctgctcacgg gtgaggggtc caagctggca ttgcggccac cttccggccc gggctctctt 840

ggggaggggc ggggttggtg agaaccggtc acgtgctccg gggctcactc ggggtctccc 900

agggccggaa gtagggcccc tgtgcgcagg cgccctgagg atcccgggct gcccatctca 960

cgccaggggg cggaacttcc tgcagcctct ctgcctccgc atcctcgtgg gccctgacct 1020

tctctctgag agccgggcag aggctccgga gccatgcagg ccgaaggcca gggcacaggg 1080

ggttcgacgg gcgatgctga tggcccagga ggccctggca ttcctgatgg cccagggggc 1140

aatgctggcg gcccaggaga ggcgggtgcc acgggcggca gaggtccccg gggcgcaggg 1200

<210>28

<211>1200

<212>DNA

<213>智人

<400>28

ttgtgaactg cctgtggaca gggcaacatg gcagagaact gagggcagct tttataacaa 60

attaagagat ttcttaatat ttaaccctcc ttacattaac tgctcgtggt atattattct 120

ttttaaaaaa ttatttatac tttttgtggg tacataatag gtatacgtat ttattggata 180

catgaaatgc tttaacatag gcacacaatg cataatgatc acataatggt aaatggggca 240

tccattcccc tcaagcgttt atcctttgtg ctacaaacaa tccaattata cttttagtta 300

tttttaaatg tacaattaaa ttattttgac tgtagtcatc ttgtgctatc aaatactagg 360

tgttaataat cacatcatgg agaatggagt atccatccct caagcgtggt gcattactct 420

ttgaatatgc tgctctggat tgtatttgct aatatgtggg gcttctctat taatgttgca 480

aaatagggag ccaataatct ggttgagaga tgaaagcagc agcaggaaaa tgtgttcaca 540

gaacctcata cgagtggcgt ctagggccaa ggctccttga atgcataccc aagggctgat 600

gagaggtggg gacgagtgct gccgaaggac tcctcaacta ccagaactac gtagggcccc 660

taacatcccc tcggagcgag ctccccgcgc cccgtacacc accaggtctc cctggttcct 720

ctcctgctcc ccgtcccgct acctcaggaa actttagccc agcctctccg atacaagccg 780

gcctccttga gggctttagg cccctcttcg ccagtgtata ccccacgaca cgcctgcgta 840

ctagggacca cccggctttg tgggcggagt ccatgagagg gttggagccc cgctcgtggc 900

cccgcccacc caagcctagg ccggccttcg tggacacgca tttccggcga cgcctcggta 960

ctgacctctg cagagccggg tggagcccat tgacgtccag cgaagcgagg agcagcgatg 1020

gacggtcggg tgcagctgat aaaggccctc ctggccttgc cgatccggcc tgcgacgcgt 1080

cgctggagga acccgattcc ctttcccgag acgtttgacg gcgataccga ccgactcccg 1140

gagttcatcg tgcagacggg ctcctacatg ttcgtggacg agaacacgtt ctccagcgac 1200

<210>29

<211>1200

<212>DNA

<213>智人

<400>29

tcgaatctgc agtgagtgat cgcaccactg cactccagcc taggcgacag aggtcaaaaa 60

caaaacaaaa gaaaacaaac aaaaaaaaca tagcaaacat ccagaagact gtgtagagca 120

atgaatgtct ctcaagccag tgatcttttt ctcttcattt ttcacatcag gtgggtagtg 180

tgcccacttc gtaacaaggt ttgagggagg cacatttgac acaagagcat gaaaacccaa 240

tcacacttat gacttacaaa aggatcaagt cagtgatctt taagctgtgg gccattaaat 300

acattttgtg agccgagtgc agtggctcag gcctgtaacc ccagcactat gggaggtgga 360

ggtgggagga tcacttgagt ccaggagttc aagaccagcc ttgggcaaca tactgggaac 420

tcccatctct attaaatttt ttttttttaa ttttgtggat tacaaccatt tcaaaaacta 480

aaataagcgt aaatgtatca aaatgcagct tacatagcga ggataaatgc tgttttgtca 540

atctgttgtt tcaagttttt tatgtgtgga ttgggtcacc ttgtaacagt gacttacctt 600

tatgggtcac ggttgaaaac atttccggtg cagtggctga ctgtaatccc agcactttgg 660

gaggccgagg ctggaagatc acttgaagcc agaagccaag agttcaagac ctgcctgggc 720

aacacggcga caccccgtct ctatttaaaa agaaaaaaaa aagtttccaa ggcactgaga 780

tgccaggaac ccgaggtgtg tgtccagtag gggagggagc aaattgggcg tttggaaaaa 840

gtcccacgcc tggaaaggaa tacacagtgg gggggtgggg ggcggggcac atcgactact 900

tcaaggcaca ctcccacggt tcagaaaacc gattggctaa aactgggaaa gtcccgccca 960

caacgctcac tggccaatgg ctgcgtgaaa tcagtgcgaa gtgggcggga tagagagcgt 1020

gggcgggggg gctagcctcg tgcgggctcc ttaagtagcg gctgcgtggc ttccctggca 1080

cgctactctt acgacgtcac ggtcaggtgg tgcagagctg gacggcaacg acgtcggacg 1140

cgccccttct tggaacaatg tcccaccacg gaggagctcc caaggcctct acgtgggtcg 1200

<210>30

<211>1200

<212>DNA

<213>智人

<400>30

cctccagttc ggcattagtt tcttcctaat gtccactctg cccgaagtga caagcggggg 60

catgtggaga ctcagctcca ggttcctgga cgggctcagc cacccccaga aagctaatga 120

atgctcaacc agggcttcca gatgcccagg ggacagagca ggagatgccg gggaatgggg 180

ctttccttgc agttcaggag ggccctgccc caggcccaga agtagaaggg aaagcggctg 240

ttttggcggt aaacagtaat gtggggagtg ctgcagagaa aggcagtctt ggggtttcaa 300

gctggagagc agtcagctac actcaggacc tctggccatc cctgccttca cctgctgttt 360

ggcctgatcg tctaacttct ctgattctcc actacccact ccttattacg tttttgagac 420

ttgtcaaagt tttatattag ggctaactgg gacgcataca aatctggtaa cttcgccagg 480

gcgggaagtt aggaaggagc agagctggct gcaggtgtct ggtcctgacc actcctctat 540

gccacccttg aggagcttgc tgactttctc atgacgttct cccattccag gagctgcaag 600

tgcgttatcc tggctggagc acggtgtcaa tcacggcaga ctaaggccag cggtgatggc 660

ttgaatgcca ggctgggggc tgggattttt cctgaggatt tcacaggaca gaggttggct 720

tggaaagacc aaggtgggac tgaggaacat tccccctacc cccaacctcg gtgggctgtt 780

gcaagcctgg aggccagaga agacgggcct gggatgccgc gggcgcaggg gcaggcagtg 840

aaggagatgg ctgccttcgg tagagctggt cgctgaggca gaagaggagg gcgtggggcg 900

tggggcgtga ggtggccggc gccccggctg gccaatggcc gggctgcggc ccctccgcgg 960

ggcggggtgg gcctggtggg cgggcggggc tcggggcggg ggcggagagg gagcctggtg 1020

ggcgggcggg gcgcgtcttg cgggctccct cgggtaccgg cgctgccgca ccccgccgcg 1080

ctcccgcacc cgcggcccgc ccaccgcgcc gctcccgcat ctgcacccgc agcccggcgg 1140

cctcccggcg ggagcgagca gatccagtcc ggcccgcagc gcaactcggt ccagtcgggg 1200

<210>31

<211>1200

<212>DNA

<213>智人

<400>31

gcactacagc ctgggtgaca aagcaagact ctgtctcaaa aaaaaaaaaa aaaacaaaaa 60

aaaacaatta atgccctcgg gtaaactatg acgtttgtgc taacttttca gatgtcccaa 120

gatttgggtt gttttacaag gataacgaag ttcatgatga ggttaagcaa tcactgaagc 180

tagtgctaga aatttttttt aatttaattt tttagaaaga ggggtcttgc agaatttttt 240

atttaatttt ttagaaagag gagtctcgct atgttgctca ggttggtctc caactactgg 300

gctcaagtga tcctcacgag tagctagggc tacaggcaca ggacactatg ccaggcttag 360

tgctacaata ttctgtctat tttactttaa aatattctaa gtatgctcac tttggaaggc 420

atcaacatcc agaaatgcat tcctacatca agactctcaa gaaacgggaa ttactgtaag 480

ggcataccct tgagcaacca tcacactgca ctgaactctt gagaatattc tggaatatcc 540

tggaagcatc tctgcagggc agagaagtga actgccacag aaggagcagc tttggggaga 600

agaaatacag tttgcctctt acagtatttt tctacaccga gagctacatt cctcccgagt 660

tttaaatttg tggaccgttg aatatcactc cgcctttcat aaagttacaa ataccttccg 720

tcggtggcgg gaacagagtt tggaaaatta catgcctaag acttcagata agctaaatga 780

catacatgca atagcatccc atgaagaatt tattcaaccc aatccattgc atctaattac 840

ccaaagcaca gaaactctcc aaactgtgca ccccccaaaa ggagggaaaa tgcaaggttc 900

ctgctgcagt tcccgggaca cactgcgagc cgctttgtta caagtgtatc caatgtcccc 960

agaacgaggg acttgtgggg cgcggctcat cccagcgcca cttgctctgc agctcccaga 1020

ggtggtggtt gtgttacgaa ggctgaccct gccaatggcc gacaaaatgg tgcgcacccc 1080

caagtgctcg agatgcagga accatggctt cctggtgccc gtcaagggac acgcgggcaa 1140

atgccgctgg aagcagtgcc tctgcgagaa gtgctacctg atctccgagc gccagaagat 1200

<210>32

<211>1200

<212>DNA

<213>智人

<400>32

atatatatat gtgtttatat atataatata tattatattt gtatacacac acacatatat 60

gccacatttt ctttatccat ttatcccttg atggacactt aggttgattc catatcttgg 120

caattgtgaa tagtgctgca ataaacatga aagtacagac gtctcttcaa cacactgatt 180

tcaaatcttc ccagtaaata cccagaaatg agattgctgg atcatatgat aattctactt 240

tcagtttttt gagaaacctc catacaattt tccatcatgt ttgtactaat ttacattcca 300

ccaacagcat acaagcattc ccttttctcc attcttgcca acacttgtta tcataaaggg 360

aggtttgaga gaccataaaa caaaccccac ctcacaattt tgttagtgca agttctattt 420

ggcctattcc caacactaag cacacagtag gtggcaaata tttgttgaat ggatgaattc 480

tcatttttct ccatttgtgg aagcagacac ctcctcaaaa aaaaaaaaaa atccgaaaga 540

aaaggtaaag gaaacagttc tatgaatggg ggttaattta ctctcctagc attcacttat 600

tgggaaaaaa agtaacagca gtttctagaa ccctctggtc tctgagggag atgctgtgtt 660

cccctcctca gagaagaaga aaacgcacta gagagtggga gcatccccaa ggctgaagcg 720

catccaggac atcacatgtc aacgtgtcct ctctggcgtg gggtccccgc gagtctggga 780

aacgaggagc tggcaaggga gggcaagcgg gggcggcaaa gagggcccct ggagcagggg 840

gcgcggacct cgctgcgctg cgcgctctac cgccgggctc gcaacgctgg gctcagcgct 900

cgcgcctccc tcagctctct cctccgcccc ccttcgccct ccccctttcc ctccctttct 960

cctcctcctc ctgccgccgc ggccgctgcc ggacttcgcc agatcagacc cacggggctg 1020

ccctcccctg cgcactcccc tcgctgcccg ggcccggagc gcagcgcggc cgcacaggta 1080

ggagccccca acggggggtc gccccgagcg agcccagtac tcactgggcc gcgcgcggga 1140

gagtgaggtg gggtgagctg aggggtgttg agtacccgag aactgccctg gactgtgcag 1200

<210>33

<211>1200

<212>DNA

<213>智人

<400>33

gagaagctct gagacatgtg agaaggtcta gtattctact agaactggaa gattgctctc 60

cgagttttgt tttgttattt tgtttaaaaa ataaaaagct tgaggccaag gcaattcata 120

ttggctcaca ggtatttttg ctgtgctgtg caaggaactc tgctagctca aggtgagtat 180

actgggaaag ccttaacgtt ctagagaaca gagttttgca gccccacctc catcccccgg 240

ggtgtgggac tggggggcag gaaatgcacc gtcccctttg aaatggatta ctgttttttc 300

ctttcgaccc cctctttctg cagcctgctt tgtaggtgca gtataaaatg cacgctgaat 360

gtcttttgta tgtaaacagc gtagcaggat ggagtaacgt gaaatgcaat tctacagcag 420

tttttacgtc tttgctgcct cgttcgttgg ctaccgagaa ggttcaggag ggggagggga 480

gatgagaaag cagattggaa gttgagtatg gtggagcctc agcctctccc accctccttt 540

cctcgcttgt gctcactgct aaagttttgt tactttcccc gcagcagata ctaaacatta 600

gtttgtcctg tattttcttt gagattcaca atgttgaaag cccttttcct aactatgctg 660

actctggcgc tggtcaagtc acaggacacc gaagaaacca tcacgtacac ggtaaggggt 720

gatggaattt gaaataagta cggttcagcg ggattctgtg acaaaaaaag actttacaca 780

cccctgccag tgtatttggg ctatactctg ctgagggtga taaattaaac aacacttcat 840

tcatgcttca tatctaagat tcgttgtaaa ttgccccctt gatcctttca aaagttcatt 900

gggctcacca cctaagatag gaaccaacat gtaatcattt gtgcagggct aaaaatggga 960

tccgttcaaa aactaaaacc aaagaaagtt acatgtttcc aaaacattca acaaattaat 1020

gggtgtaagg aactggaaaa cctggactcc taccacatgc agataaaacc aatacgtgca 1080

gaataagact caagtcaagt aagaacgtta aacaccataa agacacatgg ccttctttgt 1140

gtacatgaca tgcattctca agtaagtggc ctttattgaa tttataaagg ctatatattc 1200

<210>34

<211>1200

<212>DNA

<213>智人

<400>34

cggctaggtc ggagcggaga gtcgcagcag ccgctccggg cagcttccca gtcccggtct 60

gccttgtctg tgcggctgca agtccccgca cccacactta agcctttcac ttctacccca 120

ccgctcccag acgggctagg cccggttcca gggactgccc ccaaccctgc ccccgggaaa 180

tccacaactg gttccctgcc caaggccatc tcggggcgtc ctgggccctg ggcgaggtcc 240

acggcgtgtg cagggggacg gggccagcgg ggacttcctt actgctagaa agtcattcgt 300

tcagtctctg gagacagtga cggagccctg ctgcggactg gacgttgggg accaagtagg 360

tccccgctct ccaggcatct ggggagccag ggaagaagcg agtgatagag ccacaaaact 420

ccccgcaaag agtatttcag agggggaagc gccataaaga caaaacaggg caaggtggca 480

gagggtggcg gtggcaggcg cgagtctgca gctcagcccg ggcgcgctgg acgcagacac 540

gtcgactctc ctaaagaagc aaccgcaggt cagcttagac ttcttttatt tcaataaaag 600

agcgttttcc tccatcttaa accgcccgtg gtgggagaaa aggtttccaa cctcttctct 660

ggctcccctc ggtcaattcc gagcttttcc aaagtccctc cgccgtccag gggctcgacc 720

ttcgaggtaa cgtgggggat cccgctggct ccctccggca ggcgggggcg gggaccggcc 780

gtgctcgccc cctagagccc cgggagaccg cgcgccccgt ggagcccgga gggggcggaa 840

ccctggggcg ggccctgctc ggtgaaggcg gggctcggcc gccctgtctg cgccgccatt 900

ggccgcgggc cccggactgg cgggctcacg tcaccggccg ggcccgcccc cttggcaatg 960

tcttcagccc gctgctctcc taacttaagc atttattcca ctgggataga agcggcagga 1020

gcagcgttgg caccggcgaa ccatggctgg gattttctat ttcgccctat tttcgtgtct 1080

cttcgggatt tgcgacgctg tcacaggttc cagggtatac cccgcgaatg aaggtaagag 1140

cgggacggcc tttctgtggt cggggacagc gaggggccat cgcgggtgag gggtcctcag 1200

<210>35

<211>1200

<212>DNA

<213>智人

<400>35

aaccctgtgg agataggcaa aataagtata accccatttt acagttgagg ccacccactt 60

aataaacaag tgacaaagcc aagtttccag tattcctcaa gtgttttcct ttcaggctct 120

aaattgctga cttaaatgtc atcattagag agagttgtct cctcggtaga agtacaaatt 180

ttgttccaga gtcaaatatg aagacttgat cagtggcctg gcgcggtggc tcacgcctgt 240

aatctcagca ctttgggagg ccaaggcagg cggatcacct gaggtcggga gttcgtgacc 300

agcctgacca acatggagaa accccgtctc tactaaaaat acaaaattag ctgggcatgg 360

tggcacatgc ctataatccc agctactcag gaggctgagg caggagaatc gcttgaaccc 420

aggaagctgt ggtggcggtg agccaagatc gtgccattgc actccagcct gggtgacagg 480

agtgtgaaac tctgtctcaa aaaagaaaaa aagacttgat cagcttatag cctttatcat 540

ctagtcttct attctctgga gagtcagtgg ggactcttcc gagttcttgt agccttttct 600

taaggcctat aggaagtcat ctgtgctgag cctgcacttt ctataacaga tggaaaactg 660

aagctcagac atcttaagtg gcattgactt agactataga gctagttagt ggggggccag 720

caccatgacc tggcccctac ctccagcagg cttcacccac ccttgcaccc ttgcaggaag 780

cacttagagg cttgaggttg ccagctgtgg ggggttgggc ctgtgcagtg cctctcagcc 840

gcccacgctg gtggggctct gcagtgttag cttcttgttt ctctattttc tacctaggtt 900

tcagtttttc acttgggttt gtttcccctt tgtctctggt tcagcttcct tttcctgttt 960

ggttttaagt aggctataaa aatcaagttg ctgtcttcag agggtctgtg gtcctctgat 1020

caacataggc tggtgggagt acaggactcg cctcctcagg gttccctgtg ctgccacttt 1080

tcagccatgg ccacaaggtg agtattggaa ccagtgcagg ggacagaggg atgtcaagag 1140

gaaacctaga atcttaacgg tgaatgggct gtagaaatta tctcaggtcc ccttagtata 1200

<210>36

<211>1200

<212>DNA

<213>智人

<400>36

cttttaaatt tgtttctctt cccctttttg ttaaagtaca aaacaaaaca ccttccccca 60

cttttcgaat agttttggct gtgtctttag gactggaagg aaattcagct caaatgaatt 120

actatattat gaacttaagt aagaattgtt gtgcattttg tacagaatgc aactcctagg 180

agttgacaaa tgtttgttaa gtgcatcagt gagcgacata ggaccttctc ctccctactc 240

tcttgtcacg gtttttattt aatcaaacat ttattattgt tcgatgctct taaatgccat 300

ttccttcagc tgattatttg tatgacagaa gagtcaatta agctattttg tcctaaaaat 360

tacgaaaacg aaatgtacaa ttgtgaagta aaattttgtt cctttgcaaa ttttaataaa 420

ttattgaagt ttattttttg tttcaaataa tctgggcttc agttctaata atggaaggac 480

aatgtgaagg cccagaattc agcatagcgc ctggcattaa taggaggtca gtacattttt 540

agtacatgtt tctcaaatag atcttaaaat ttcatttaag agcgtttcct cacgtcacag 600

tatgtctctg gcgttactta attttgaaaa acctcaacac agattctagt tttaggcaaa 660

gctcagaaaa tttctactta aggatatttc caaagcgaaa ggaagcgcgg agacgttcat 720

gactggcatc atctcgcacg tggttccgga aattctcggt aggatgccct acatctgctc 780

tccctccact aagaagaacc tctttgtgtg gcgaaagtaa aagtattagg gcttttaagt 840

tgcccagagt caaggaacac ggataaagac gctgggagat tgacatgcat ttcgaccaat 900

agcattgcag agaggcgtat catttcgcgg atgttccaat cagtacgcag agagtcgccg 960

tctccaaggt gaaagcggaa gtagggcctt cgcgcacctc atggaatccc ttctgcagca 1020

cctggatcgc ttttccgagc ttctggcggt ctcaagcact acctacgtca gcacctggga 1080

ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac ctgcgccaca tccatcggcg 1140

ctttggtcgg catggcccca ttcgcacggc tctggagcgg cggctgcaca accagtggag 1200

<210>37

<211>1200

<212>DNA

<213>智人

<400>37

gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60

ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120

caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180

agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240

gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300

cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360

gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420

gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480

ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540

aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600

gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660

tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720

tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780

aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840

ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900

cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960

ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020

gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080

gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140

ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200

<210>38

<211>1200

<212>DNA

<213>智人

<400>38

gcacaggctg ccagctcagg ctttggcccc tccatccgct cctggcttct ctgtgggtgg 60

ccccatctaa gccaatgggc ccttcctggc tccacctcct ctctgctgtg cggccctggg 120

caggcagctg ccctgccctg tgcctttgct cttggctgcc tcacccctgt cctgggctgc 180

agggagaccc ctgggggtgg gggcaggcac actttgggcc catggctgct gctcagatgt 240

gaggtggtga ccaccaggcc atacgtctct ggacagggat gggagagact cagagagaca 300

cagagaccaa gagataaagt cagagggaga tgcagagacc aagagggaca aaccaaggga 360

gacagagaga tgacattaga tcagagatgg agaccccgaa agagacccag aaagggatcg 420

gtgtgggctg ggggaagaga caccccgggg gtcacacagt ggtcacaggc atcagagctg 480

ggctgaggaa aaggacaaac tgaacctgtt ccaaagctgg gggctcagta ccgtctgccc 540

aggcacatgc agcagcagtg gggctgcagg caggccccca gggtaggaag caaggcgggt 600

gggaggcagg gcctggcctc tgggcagttt tgtagccggg cccctcaggc cctcacaatg 660

tgcccaaggc tgctgggccc atcttccagg ggtgatcact gaggctcagg ctggctgagg 720

tggccggacc ccaacccctg gccctgccct gtgggcagca gtgccaggtc tggcactcag 780

aggttaggcc gggcgcaggg agggtgcggg ctccgcagcg agcgcgccgg gcggcctcta 840

ggagccgggt cagcgagtct gggctctgag cgagcggcgc cggcccggcc ccctctccgg 900

cgggcggccg agaccccgcc ccggaggcgg aggcggagtc aggggagggg gccgggggcc 960

ggctggtccc gcctctcgcg cctccgcccc gccccgcgcg cacacagcca ggggccgccc 1020

gggctctcga cgcgccgacg gccgggcgga cggacggacg gacgccgagc gcagtgcccc 1080

gcggtgagtg cacgcggccc ctcccgcccg gactcatccc cgtcggtccg cgcctcgcag 1140

ctcaggactc gggggcgctc ggacgcaccg acggctcggc ggaccctcgg acgcgcctcg 1200

<210>39

<211>1200

<212>DNA

<213>智人

<400>39

cccgcccctt cccccggaga cgcgcccacc cggccaccgc tctcttccca ctcccccatt 60

acccgcagcc ctcactcccc gctgcgggaa ggggctgctt ggctgcctct gggggtcttc 120

agagctaccc tggtcccggg ggattggagg aggaggttac ctatcctgcg tcgtctttaa 180

tccgtgcacc actatccatc aaatagagac agatcctggg cctctcaaag acggatgatt 240

gggggtggtg attggcctat ccctaaatat ctaccacgca aggactcttg agagatccag 300

accccggtac agtcgaggga cctggggccc aaaaagggaa agcggctacc tctaccacac 360

agttgggaag cgcagtccta aaggagacgc aggttggaga ctccgctaag cggagaagcc 420

gcagtggggc catggcaagt caccttccct ttcgggccta ggaatactca ttcgaaagat 480

ggggggactg gagtgccgag tggctgtggc agccacgatt ggggtttgga aaccatcctg 540

aaaggcccgg ggagccagtc tcctggaact tctccctccc cattcccaca aaaaccaagc 600

gccctctcgg ccaattctca ccctctcagg acaaaaaagt gagatgagcc cgtcctttca 660

cctgcgagtc caagcccttg gcagaggcct gaaaagtccg aaaactccga gttcgggcgc 720

tgaggtctcc cgagccggtt cctgaactct ccgggcctca gtcgatcggg gtgcggaggg 780

ggccgacccg ggggatctcc aagcgccctc cccgccctga cgctgtgggg ctcctaccgc 840

gccgccacag ctgctcctac ctggggaggt gcgcccgggc cccggggggc gggcagtcgg 900

ggggcgggca gggaaccggt gccgccccac gcttcgtggc ccctttaagg aggggaagcc 960

ggcggaggga ggagccggtc cggtgtgtgc aggggagcgc ctcgccagcg gtccgcaggg 1020

ctggagaccc acgccgtgga gaggaccagc ctcaggtcgc cccgcctggg cccgcgcccc 1080

gacctcgctg cccccgcctc gcctctctgc ccgtggcgct tacggccacc ttggcctcgg 1140

gggcagggca tgggcggccc ccgccagatc gcccagcgcc agtactaact gccctcgctc 1200

<210>40

<211>1200

<212>DNA

<213>智人

<400>40

ggttacctat cctgcgtcgt ctttaatccg tgcaccacta tccatcaaat agagacagat 60

cctgggcctc tcaaagacgg atgattgggg gtggtgattg gcctatccct aaatatctac 120

cacgcaagga ctcttgagag atccagaccc cggtacagtc gagggacctg gggcccaaaa 180

agggaaagcg gctacctcta ccacacagtt gggaagcgca gtcctaaagg agacgcaggt 240

tggagactcc gctaagcgga gaagccgcag tggggccatg gcaagtcacc ttccctttcg 300

ggcctaggaa tactcattcg aaagatgggg ggactggagt gccgagtggc tgtggcagcc 360

acgattgggg tttggaaacc atcctgaaag gcccggggag ccagtctcct ggaacttctc 420

cctccccatt cccacaaaaa ccaagcgccc tctcggccaa ttctcaccct ctcaggacaa 480

aaaagtgaga tgagcccgtc ctttcacctg cgagtccaag cccttggcag aggcctgaaa 540

agtccgaaaa ctccgagttc gggcgctgag gtctcccgag ccggttcctg aactctccgg 600

gcctcagtcg atcggggtgc ggagggggcc gacccggggg atctccaagc gccctccccg 660

ccctgacgct gtggggctcc taccgcgccg ccacagctgc tcctacctgg ggaggtgcgc 720

ccgggccccg gggggcgggc agtcgggggg cgggcaggga accggtgccg ccccacgctt 780

cgtggcccct ttaaggaggg gaagccggcg gagggaggag ccggtccggt gtgtgcaggg 840

gagcgcctcg ccagcggtcc gcagggctgg agacccacgc cgtggagagg accagcctca 900

ggtcgccccg cctgggcccg cgccccgacc tcgctgcccc cgcctcgcct ctctgcccgt 960

ggcgcttacg gccaccttgg cctcgggggc agggcatggg cggcccccgc cagatcgccc 1020

agcgccagta ctaactgccc tcgctctggc cttcgagccc gaagcctctt ctgcgcgcac 1080

aacctaggca gtaatcctaa actagcgggc accacagacc agctgcagcc accccaaccc 1140

agggatcact tccggacccc tcgaccgccc ggcaccagcg cgcaagggac ccttcagccg 1200

<210>41

<211>1200

<212>DNA

<213>智人

<400>41

ctgacgacta tttccagaga tcctctcccc tgccccattc cagcccagtc actctgagag 60

cgcgagggac aggccaggcc gaggcttctt cgtacagtca cacccgtttc tgggctgact 120

ttcccaaagc ctcagagcag ctctccccac cctaccccgt ccagccccct cgccgtctcg 180

cccctcccca gccccgagct agaagttcag cctcaagacg gcagcaaacg gcagagcaaa 240

ggagtcgttt tctttcacct gaaagccgcg aggaggcttg gagcgccttt cctcgctggg 300

gcccgagctt cctgggcttt ggccgggtgc gggcagaccc caccggggtc ctcgtcatct 360

cccagcccag cccgcagagc gagtaccggc agatttcaag ggcgcgtgag cctggctgtc 420

ggctgggccc ctgaggctcg ctgggcgggg gcaggccggt ccaggctgtg cggggcgttt 480

acaaaaagtg acttggagat gaactcgccc gtgcgcggct ggccgccccg ctataggggc 540

gaaggcgcct gacgcaagcg gaactcggtg gagcccatac gaatcagaac agagcgaggc 600

tcctggcgca ctagggactc caggaggcag ctccgccaga gacgcgggtc gtgcttcggg 660

aaaccggggg gcggggggag gggaagagcg cagaaaagaa aacccaccaa ggcggggact 720

ggcctgagcg gggaggggcg gcgaggccgg agcccctctc tgttgggcgg actccccatg 780

gccagaggct gagctccact cccgccggcc gctccctagg ggaaggggaa ggagagggga 840

gagcagcgac aggcctccag caagcaagcg cgggcggcat ccgcagtctc cagaagtttg 900

agacttggcc gtaagcggac tcgtgcgccc caactctttg ccgcgccagc gcctggagcg 960

gagagcagag gcggcccggc cgcggcgcgc cggctttgtc atgatggcca gctaccccga 1020

gcccgaggac gcggcggggg ccctgctggc cccagagacc ggtcgcacag tcaaggagcc 1080

agaagggccg ccgccgagcc caggcaaggg cggtgggggt ggcggcggga cagccccgga 1140

gaagccggac ccggcgcaga agcccccgta ctcgtacgtg gcgctcatcg ccatggcgat 1200

<210>42

<211>1200

<212>DNA

<213>智人

<400>42

gaaaggagct cataggaagg ggcacagcac aaggctcccg aaagaggtca ctgcaagtgt 60

cctgcgcaat ttctgttcag cacctctgca gtgacgacag gggtttgctt tcgtaagcag 120

catcgttttc actactacag aagcacatac gccgcgtgca gcttaggccc gagcaaagtc 180

cctgctcccc tagacccagt cccttcaggt gtccccctag gggaactgtg gcgtgtcccc 240

ccaaccaggc gcactcgcct aaactgcgtc cccgaactcc agggcgcagg gagccctcgc 300

gggctgcccg gggctggggc ccacacctga acggaggagc cggctggcgg agcggccccg 360

cgcgcgcaca cacgcacact cacagacacg cgcaaaccca cagcggcgcg cgcgctcccc 420

attggcggga ggaggaaggc ggggccggcc gacccaaaac aaacaacctg cgccagcgac 480

tttgccgccg cgctgcagtg tggcctccgc ctggtgcgcg cccgttgggg agctggggaa 540

ctggggagcc gccaccacct cggccacctc gttcccccac cccttgccgt ccgcgctcag 600

gccccgcccc cgcggagccg ccgcagggtt atattgggcc ggcccgaagg tggaggcgag 660

acgcagccgc ggcaggccag cggggagatg ctgccccgga ggctgggagc gggaaggcgg 720

ctgcgggcgc agcggcctcg gggactcgcc tccgcgggtg ctcaaggctg aaggcgccgg 780

accttccccc acggtggcac gcacatcatc cggcaccatt tccgtgcccc gaagacgccc 840

gcgcgggacc tgggaccgcc agtgaagaac ccctcctggg ctctttaacg agcagcagat 900

gcgcatgctg cttctctccg gcaggaaagc cttctaagcc cggcgtgctc gggcacccga 960

gggtggaacc gcggcccctg cacacactca ccccaaagtc tcaacgtcga accgaaggcg 1020

acacccaccc aactcctccc tctccgcccc atagtccacc caacacttgc agcccctcca 1080

gagaaaaagc ccagcggaag aggactccgg aaaagtgact atctcggaag accagggtag 1140

agctcccggg agaaaaaggc gaagatcccc ggccccggat cgccatcccc ttccctggca 1200

<210>43

<211>1200

<212>DNA

<213>智人

<400>43

gctcccgaaa gaggtcactg caagtgtcct gcgcaattt ctgttcagcac ctctgcagtg 60

acgacagggg tttgctttcg taagcagcat cgttttcact actacagaag cacatacgcc 120

gcgtgcagct taggcccgag caaagtccct gctcccctag acccagtccc ttcaggtgtc 180

cccctagggg aactgtggcg tgtcccccca accaggcgca ctcgcctaaa ctgcgtcccc 240

gaactccagg gcgcagggag ccctcgcggg ctgcccgggg ctggggccca cacctgaacg 300

gaggagccgg ctggcggagc ggccccgcgc gcgcacacac gcacactcac agacacgcgc 360

aaacccacag cggcgcgcgc gctccccatt ggcgggagga ggaaggcggg gccggccgac 420

ccaaaacaaa caacctgcgc cagcgacttt gccgccgcgc tgcagtgtgg cctccgcctg 480

gtgcgcgccc gttggggagc tggggaactg gggagccgcc accacctcgg ccacctcgtt 540

cccccacccc ttgccgtccg cgctcaggcc ccgcccccgc ggagccgccg cagggttata 600

ttgggccggc ccgaaggtgg aggcgagacg cagccgcggc aggccagcgg ggagatgctg 660

ccccggaggc tgggagcggg aaggcggctg cgggcgcagc ggcctcgggg actcgcctcc 720

gcgggtgctc aaggctgaag gcgccggacc ttcccccacg gtggcacgca catcatccgg 780

caccatttcc gtgccccgaa gacgcccgcg cgggacctgg gaccgccagt gaagaacccc 840

tcctgggctc tttaacgagc agcagatgcg catgctgctt ctctccggca ggaaagcctt 900

ctaagcccgg cgtgctcggg cacccgaggg tggaaccgcg gcccctgcac acactcaccc 960

caaagtctca acgtcgaacc gaaggcgaca cccacccaac tcctccctct ccgccccata 1020

gtccacccaa cacttgcagc ccctccagag aaaaagccca gcggaagagg actccggaaa 1080

agtgactatc tcggaagacc agggtagagc tcccgggaga aaaaggcgaa gatccccggc 1140

cccggatcgc catccccttc cctggcacca gcttctctag gctgcgcgaa ggaagagggt 1200

<210>44

<211>1200

<212>DNA

<213>智人

<400>44

gggactaata gatttattcc aggtgatagt gggaagcagc tacagaagga ggattggaag 60

gctgaggggt tgttaaagtt atctgatgat attgttcgaa catttctccg gcacagaaac 120

tccacaaaga actcctctgc agttttcgct acccagggct gtttctttaa attgtttgac 180

gtcagagaag gaatgctata gcaacagtct gtcaaactgg aattaactca gaagaaaaat 240

gggggtgggg agaggaaaaa tgctcccagg cggtactgac ttcagaggaa gcaaattgga 300

tagatgcatt tattttatga cattttaaac ataaaacacc cagataaatg tgaaaaaaaa 360

aaaaactcga ttgagatgca tgtggtgttt aactcatgca gagaagagcg acttggcagg 420

gatatctgga aggccttcca gttttatcaa tgacaatagg aacaataact tccaagtatt 480

ggccatttat ttggaggcag gcttcgtgca aacatcactt catttaatat gcttagcacc 540

tttatgaggc aggtatcagt atctttattt tggcgatgac gaaacttagg cccgagacgg 600

tacacggtcc tacaactagt gatggaagag cggggactgc aacgcaaggt tgtgcaactc 660

tgggcttcag tttactttct gacatttaga attccagaat gggaaaccta aatggggcct 720

ttggggtctt ctagctctgc ccttcgatcc tgctaacaag caaactggcg cctgtcagcg 780

ccggaaagga aactggccac gccacttaga cgggcgctac ttagcagcgt gccccggcgc 840

cacaccaaca agaaaacgaa actgcccggg aatgaatgtt tttcttctcc ttctggcagg 900

aaacgagaga gaaaatagga agcagaagct gcgcgcggcg cccgctccct tcgccccccg 960

cccgggctgc gcgcgctccg agggtctgcg cgtccccggc acgtccccgc cgggcccgcg 1020

cgcctcgtgc ctcgcgcctc gcgcctccag ccacgtcccc gccccggctc cggcgcgccg 1080

cggagttggc tgctgggagg tgcgggactg ggtgtggccg gcggctctgg tctcggctgt 1140

gagctgcgct ctccacgccg gctccgcgct ccaggggctg ctgagcgccc agcggacacc 1200

<210>45

<211>1200

<212>DNA

<213>智人

<400>45

gtaaccagga atgatttgac tgtataaatt tatcttacag acacacttgt ttgtacattt 60

aatgcctgct ttctataata tgaaaaaata cacagaacgt tttatgcaat tggctctgag 120

taatgcaaca cataaatgct ttgagagcag ttaccaaaaa ttatgcaggt tattacaaaa 180

gttatatgga attgcacaga tattctaaat gtgcttttga gtaaatttct cagctaccag 240

aggcctgggc agctgtttcc agcacatcct ggcacaacat tcatgttatc atccacttat 300

gtattccaca atttcaaatg attgataaga cacctccccc atctttgctt cctcttggag 360

gaaaaaaata tacaagcaat cacgagcaca ggagcaggtg gacaactaca tcttaggaaa 420

gggtgcgtaa ctgtgaactc taaacgtgag ctgggtgcct gatgcagtat aggaaccaca 480

gtaagtcgat aatcagtgag gctggaggat tgaaatttta tttggtaaag aatattgagc 540

caggcgcggt ggctcatgcc tgtaatccca gcactttggg aagccgaggc gggcagatca 600

caaggtcagg agatcgagac cagcctggcc aacatagtga aacctgcctc tactaaaaat 660

acaaaaaatt agccgggcat ggtggcgggc acctgtaatt ccagctactc aggaggctga 720

ggcaggagaa tggcttgaac ctgggaggtg gaagttgcag tgagctgaga tcgtgccatt 780

gcactccagc ctgggagaca gtgtgagact ccatctcaaa aaaaaaaaat gaatattgaa 840

atagagtcta taggaaaaaa actccttgaa tctagtaaat gtggaatcac aaaattgaaa 900

taatgtgcat ctgaaaagtg aataaataga tgccaagaag gagtgagtca taagcacatg 960

agttgtaaga ggttgaactt gagagaccag atcaggcagt gccgcttaat accatcacat 1020

gatcctcccc gaggccctgt atttaattaa aatagagagg gaggcaccac agatgccaga 1080

agaacactgt tgctcttggt ggacgggccc agaggaattc agagttaaac cttgagtgcc 1140

tgcgtccgtg agaattcagc atggaatgtc tctactattt cctgggattt ctgctcctgg 1200

<210>46

<211>1200

<212>DNA

<213>智人

<400>46

tcctacctcc ctggccactc cttttcagac tcctttgctg gtttgctctc atttttccct 60

aacctttaca tgttgatatg ccagagcacc tcaaaccctt agacctcatc tctgctactc 120

gtgctcccat ggtgatctca tctagtctct ggtttcaaac acagagtgat cactcctgta 180

cttgctgttt cccttttcct ggagttctct ctgcctcctg caggtaggaa gtgattcgag 240

ataagagagg gagagaactc ttctggccag gatagagggt gattctgaga aggcttcaag 300

gaagaagtga gcatttgagc acggctactt gaggaaggct aggccatgga cattagggtg 360

caggcaggag cagagcaaac atgcttgtaa aaggaacagc aattattctg ttttatattt 420

atatcagccc atggtggccc ccacagcaga gtggcttgat ctctcacctc cttcaggtct 480

ttgtttaaag attaacttct ccatgaggcc ttctatgaac ataaccttta aaaacataaa 540

tccccttcct actgggactc ccccagttcc caccctgaga ccccctatct ctcttctcga 600

ttttatttct ctccatagga tgtgtatcac cacctgactt actagctatt tactatatat 660

tagtttattt cttccccatt agaatgtaaa cttcctgagg gcagggattt tgtctgttga 720

gttcagttct gtatccccag cacctaaaac agtgcctgtc cataacaggc atgttaaaca 780

ttgttggaca gatgaatgag tgaatgaaaa atggtagtac ctttcctcct ccagtccatc 840

ctacacaaag aggcaagatt aatttcccta aatgcgtgag cattaggaag tgggagggat 900

tggaggagga aattataata aggaatccat aaattactta agcccataaa acaaaggtag 960

gaaacattca agataagaga cctcttctgg ccaggataga ggttggttct gagaaggctt 1020

caaggaatag gcagacattt cagcaaggct gctgaggaag gataggctgt ggaaattagg 1080

atgcaggtag gaggatcaca gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga 1140

aggaacagca agtattgttg ggttgggctg gcttatgaag ttgtgacggg ctgagggaga 1200

<210>47

<211>1200

<212>DNA

<213>智人

<400>47

tgtgtatcac cacctgactt actagctatt tactatatat tagtttattt cttccccatt 60

agaatgtaaa cttcctgagg gcagggattt tgtctgttga gttcagttct gtatccccag 120

cacctaaaac agtgcctgtc cataacaggc atgttaaaca ttgttggaca gatgaatgag 180

tgaatgaaaa atggtagtac ctttcctcct ccagtccatc ctacacaaag aggcaagatt 240

aatttcccta aatgcgtgag cattaggaag tgggagggat tggaggagga aattataata 300

aggaatccat aaattactta agcccataaa acaaaggtag gaaacattca agataagaga 360

cctcttctgg ccaggataga ggttggttct gagaaggctt caaggaatag gcagacattt 420

cagcaaggct gctgaggaag gataggctgt ggaaattagg atgcaggtag gaggatcaca 480

gagcaaacac tccaaggtgg gaaatgcaag tgtgtgtaga aggaacagca agtattgttg 540

ggttgggctg gcttatgaag ttgtgacggg ctgagggaga gacaggactg gaaaagcacg 600

ttggggtcag gttgcagagg tccttgactg acagagaggg gagcttggtc tgtggggaat 660

cttctgctct gtgtggtcag aggctggtct gactctccgg ccttgcccca gtcttcctat 720

ccttcatcca gccccggctg gctcggtaaa aacggcgcga atctcgctct ccctgggtaa 780

ctagggtccc cactgcctgg ctagtggtgc ttttcgcgtc ttcactggca ccattaatga 840

atgaagtctg gctcccaccc gcggggaagg gaggagcctc aacctcgggt cctttgctct 900

cctgcagcac tcctgcccgg gtcccgcctc ggggtcgcca ggccctgaac cccaacgccg 960

gcattagtcg cgcctgcgca cggccctgtg gagccgcgga ggcaagggac ggagaacggg 1020

gcggaggcgg agtcagggcg cccgcgcgtg ggccccgccc ccttatgtcg ggtataaagc 1080

ccctcccgct cacagtttcc ctagtcctcg aaggctcgga agcccgtcac catgtcgtgc 1140

gagtcgtcta tggttctcgg gtactgggat attcgtgggg tgagtgccgt ctcaacggta 1200

<210>48

<211>1200

<212>DNA

<213>智人

<400>48

actgacactt tcattcatat gtttagaaga gacatatctg aagaaaattc tttttaaaat 60

agtttctcag ctgagattat acttttttag tgtgtagctc acaggaagtt ctagttgcca 120

agagcatgtt cgatatgagt agatctctac ctaattctta tgcataatga acccaatttt 180

catctcttct agaaagatac tgaaaacatg tgtcgtgatc tcaatgttac aaccatgtag 240

cctcatcttt cacaatacgg tacaatcacc aacgaagttt aaacttcatg tctggcatcc 300

aaggtgaaca tttccataga aagtaggaaa tatttagatg tctgtttgcc gtggtggtgg 360

tgttcctata tactttttgt gaccctaaag atataataat gtttgacatt tttgttagcc 420

agtaatgtgg acttaagaca tcctaaccac actgctgact ctaacccttt aatagacttt 480

cacgtagttc ttgagcctca ctgcaggctc cagtgctagt cccggaggaa atcagaaaag 540

ggttgaaacc actgacacag ccatctcttt agctcctcct aacgcaggtg tacagtttcc 600

tgtagtgagc agatcggggc ctacagggac actgcatgct tgcactgggc tgttactagt 660

ttcatggaaa tatgtactaa ttgtgtcact gtgttttctt gtcacactgc cccctttcta 720

ggccgctctg gcaccgttta tttaaactgt gcaaccatct ggcccaggtg ccgtagagat 780

tgatcagtag cacaaggcca ccacaagcac aaccgccacc cggccatccc agctatttcc 840

tccagcattc tagacatcat ggcgtccgag ggtgggtcca acgggcttcg agtgttcggg 900

agataatgca cacttcgcag tggatcttct cggggccccg agcgttgccc gcccattagg 960

tggcgccggt cccctcgaac aggtcgctca acaactcccg cccagcagcc gcccttactg 1020

cgcgcgcgca gacttcggcg tctacttccg gtgtggccca ggcggggtcc gcagaaccag 1080

ctatgtcggc ctacggcatg cccatgtaca agagcgggga cctggtgttt gccaagttaa 1140

agggctatgc ccactggccg gcgaggatag agcacatgac ccagcccaac cgctaccagg 1200

<210>49

<211>1200

<212>DNA

<213>智人

<400>49

tttttagtgt gtagctcaca ggaagttcta gttgccaaga gcatgttcga tatgagtaga 60

tctctaccta attcttatgc ataatgaacc caattttcat ctcttctaga aagatactga 120

aaacatgtgt cgtgatctca atgttacaac catgtagcct catctttcac aatacggtac 180

aatcaccaac gaagtttaaa cttcatgtct ggcatccaag gtgaacattt ccatagaaag 240

taggaaatat ttagatgtct gtttgccgtg gtggtggtgt tcctatatac tttttgtgac 300

cctaaagata taataatgtt tgacattttt gttagccagt aatgtggact taagacatcc 360

taaccacact gctgactcta accctttaat agactttcac gtagttcttg agcctcactg 420

caggctccag tgctagtccc ggaggaaatc agaaaagggt tgaaaccact gacacagcca 480

tctctttagc tcctcctaac gcaggtgtac agtttcctgt agtgagcaga tcggggccta 540

cagggacact gcatgcttgc actgggctgt tactagtttc atggaaatat gtactaattg 600

tgtcactgtg ttttcttgtc acactgcccc ctttctaggc cgctctggca ccgtttattt 660

aaactgtgca accatctggc ccaggtgccg tagagattga tcagtagcac aaggccacca 720

caagcacaac cgccacccgg ccatcccagc tatttcctcc agcattctag acatcatggc 780

gtccgagggt gggtccaacg ggcttcgagt gttcgggaga taatgcacac ttcgcagtgg 840

atcttctcgg ggccccgagc gttgcccgcc cattaggtgg cgccggtccc ctcgaacagg 900

tcgctcaaca actcccgccc agcagccgcc cttactgcgc gcgcgcagac ttcggcgtct 960

acttccggtg tggcccaggc ggggtccgca gaaccagcta tgtcggccta cggcatgccc 1020

atgtacaaga gcggggacct ggtgtttgcc aagttaaagg gctatgccca ctggccggcg 1080

aggatagagc acatgaccca gcccaaccgc taccaggtgt ttttcttcgg gacccacgag 1140

acggccttcc tgagtcccaa acgcctgttc ccgtacaagg agtgcaagga gaagttcggc 1200

<210>50

<211>1200

<212>DNA

<213>智人

<400>50

aaaggcaaat tatgtgcaca tgaccctgtc actacaaggt agttctcgac caagctacat 60

cttatagctt tatcttatat tcctctccca tcatctgcag gaaaagggat aggtgctgag 120

ggaaaacccc taagtagaac tcacagtaag cagtgggaaa acagcttatt tcactaacgg 180

ggttaagtgg ccctgaaaag agcctttgga gacaaagcag ccggcgaccc gcggagggag 240

ggagggaggg agcgagcgag cgccaggtcc cggcagggac tcacttggag ctggcgtact 300

tggtgaccgc cttggtgccc tcggacacgg cgtgcttggc cagctcgccg ggcagcagca 360

ggcgcacggc cgtctggatc tccgggacgt gatggtggag cgcttgttgt agtgcgccag 420

gcgggacgcc tctcccgcga tgcgctcgaa gatgtcgttg aggaaggagt tcatgatgcc 480

catggccttg caccagatgc cggtgtcggg gtggacccgc ttcagcacct tgtacacgta 540

gatggagtag ctctccttgc ggctgcgctt gcgcttcttg ccgtctttct tctgggcttt 600

ggtgacggct ttcttggagc ccttcttggg agccggcgcg aactttgcag gctcaggcat 660

ggccagaccc aagaccgaca ccgacccccg agaacgcaag cagagcggta ggctcggggt 720

ctaccggaaa cgactgtgta cttacagagg ctgtgcgcat gacgctgcgt tatggttcgc 780

gagttttccg cggcgcgcaa tgcgagggag acgagattat gtaaatgagt ggattctggc 840

tgagctatcc tattggctat cgggacaaaa tttgcttgag ccaatcaaag tgctccgtgg 900

acaatcgccg ttctgtctat aaaaaggtga agcagcggcg ttttcggcga ctttcccgat 960

cgccaggcag gagtttctct cggtgactac tatcgctgtc atgtctggtc gtggcaagca 1020

aggaggcaag gcccgcgcca aggccaagtc gcgctcgtcc cgcgctggcc ttcagttccc 1080

ggtagggcga gtgcatcgct tgctgcgcaa aggcaactac gcggagcgag tgggggccgg 1140

cgcgcccgtc tacatggctg cggtcctcga gtatctgacc gccgagatcc tggagctggc 1200

<210>51

<211>1200

<212>DNA

<213>智人

<400>51

ctatataaac caaaaattgc ttcaaccaca gaatggaggt ctacaggtgc ggaaggaaag 60

tttatatggt gaggcttggt cgcaaaacta ttaggaatat tttcaggtta ctacacaatt 120

ttgcgagctc aatatgcagt taacactttt tccctcgact ctcctgagca gatttacatt 180

gaccgcaccc gtagcatatc gtctcacttt ggaaaaggca aattatgtgc acatgaccct 240

gtcactacaa ggtagttctc gaccaagcta catcttatag ctttatctta tattcctctc 300

ccatcatctg caggaaaagg gataggtgct gagggaaaac ccctaagtag aactcacagt 360

aagcagtggg aaaacagctt atttcactaa cggggttaag tggccctgaa aagagccttt 420

ggagacaaag cagccggcga cccgcggagg gagggaggga gggagcgagc gagcgccagg 480

tcccggcagg gactcacttg gagctggcgt acttggtgac cgccttggtg ccctcggaca 540

cggcgtgctt ggccagctcg ccgggcagca gcaggcgcac ggccgtctgg atctccggga 600

cgtgatggtg gagcgcttgt tgtagtgcgc caggcgggac gcctctcccg cgatgcgctc 660

gaagatgtcg ttgaggaagg agttcatgat gcccatggcc ttgcaccaga tgccggtgtc 720

ggggtggacc cgcttcagca ccttgtacac gtagatggag tagctctcct tgcggctgcg 780

cttgcgcttc ttgccgtctt tcttctgggc tttggtgacg gctttcttgg agcccttctt 840

gggagccggc gcgaactttg caggctcagg catggccaga cccaagaccg acaccgaccc 900

ccgagaacgc aagcagagcg gtaggctcgg ggtctaccgg aaacgactgt gtacttacag 960

aggctgtgcg catgacgctg cgttatggtt cgcgagtttt ccgcggcgcg caatgcgagg 1020

gagacgagat tatgtaaatg agtggattct ggctgagcta tcctattggc tatcgggaca 1080

aaatttgctt gagccaatca aagtgctccg tggacaatcg ccgttctgtc tataaaaagg 1140

tgaagcagcg gcgttttcgg cgactttccc gatcgccagg caggagtttc tctcggtgac 1200

<210>52

<211>1200

<212>DNA

<213>智人

<400>52

gatggagcag aagctctaat tgcttcgagg tacaagtcca tctaaacctc tgagatctca 60

cccgtccccg gtaagccctt gcgccctcca gacaagctcc tcagtgaaag caagcgccgc 120

accggtgcct gtgccagtct cccagaaagg agcataagga gtgttccacc accactctgg 180

attctttatt ccaacaaccc agccggaggg gaaaatctgc taaaccaccc cacaaggcag 240

aaactttatc aaaatctggc actacaacac tggccctcat cacgccgcca caaattgcga 300

gggatagaag aaagctgcaa agtcacgtta aaaggaagcc tagtcaaaaa gtgaaaattt 360

tgtcccgccc taggcacaca gcactcacag cataagatgt agttccatga gtcctaggaa 420

agggggaaga aaggaaaaaa ccaaacatct gctctaggtt tagaagaggg ataacatcag 480

cgccaagcaa accgaaagcg cagaggactc agaagagggg aagaggaata actttatctg 540

tcctggaggt gggcgaagag cagtctccac cggccgcgcg tcacgctccc atttaacctt 600

ttccatgccg cgacgcccac actccgccct cgagggacta gcccccccca cgatccagag 660

cagaagcggc tcgccccgct gcatccacgg gccctcaccc aagcgtccag tcctgccttt 720

ctccccccac ctcgcccaat acctgtccga gagcaggcgt tctgccctct cgccccgccc 780

ttgcccaggc agcccccggt cgcgacggct ctcctcgggg ctcgggggcg ctgggcggcg 840

gccctgggct gctttggcta acttggctgc ggggcaggcg cgaggagcgg cgcgccgacc 900

gggccgagcg gagaggccgc ccattggccg gccagcgcca cgtggccgcc cccgccggta 960

tattaggcca ctatttacct ccggctcact cgccatgggt tggagagggc agctcgggta 1020

gagagggctg gcggagcggc gcagacggcg gcagtcctgc tcagcctctg cccggctccg 1080

tactccggcc ccggcctgcg ccctcagaaa ggtggggccc gaaccatgag ctcctacctg 1140

gagtacgtgt catgcagcag cagcggcggg gtcggcggcg acgtgctcag cttggcaccc 1200

<210>53

<211>1200

<212>DNA

<213>智人

<400>53

gcctgtgcca gtctcccaga aaggagcata aggagtgttc caccaccact ctggattctt 60

tattccaaca acccagccgg aggggaaaat ctgctaaacc accccacaag gcagaaactt 120

tatcaaaatc tggcactaca acactggccc tcatcacgcc gccacaaatt gcgagggata 180

gaagaaagct gcaaagtcac gttaaaagga agcctagtca aaaagtgaaa attttgtccc 240

gccctaggca cacagcactc acagcataag atgtagttcc atgagtccta ggaaaggggg 300

aagaaaggaa aaaaccaaac atctgctcta ggtttagaag agggataaca tcagcgccaa 360

gcaaaccgaa agcgcagagg actcagaaga ggggaagagg aataacttta tctgtcctgg 420

aggtgggcga agagcagtct ccaccggccg cgcgtcacgc tcccatttaa ccttttccat 480

gccgcgacgc ccacactccg ccctcgaggg actagccccc cccacgatcc agagcagaag 540

cggctcgccc cgctgcatcc acgggccctc acccaagcgt ccagtcctgc ctttctcccc 600

ccacctcgcc caatacctgt ccgagagcag gcgttctgcc ctctcgcccc gcccttgccc 660

aggcagcccc cggtcgcgac ggctctcctc ggggctcggg ggcgctgggc ggcggccctg 720

ggctgctttg gctaacttgg ctgcggggca ggcgcgagga gcggcgcgcc gaccgggccg 780

agcggagagg ccgcccattg gccggccagc gccacgtggc cgcccccgcc ggtatattag 840

gccactattt acctccggct cactcgccat gggttggaga gggcagctcg ggtagagagg 900

gctggcggag cggcgcagac ggcggcagtc ctgctcagcc tctgcccggc tccgtactcc 960

ggccccggcc tgcgccctca gaaaggtggg gcccgaacca tgagctccta cctggagtac 1020

gtgtcatgca gcagcagcgg cggggtcggc ggcgacgtgc tcagcttggc acccaagttc 1080

tgccgctccg acgcccggcc cgtggctctg cagcccgcct tccctctggg caacggcgac 1140

ggcgccttcg tcagctgtct gcccctggcc gccgcccgac cctcgccttc gcccccggcc 1200

<210>54

<211>1200

<212>DNA

<213>智人

<400>54

aacagtgtga aaagtcacat gataaactgg ggaagatatt tacagtacat gtaatggaca 60

gagggttaat gttcttgcta gatatcttaa aatcaagaaa aataaactca gtaaaaagat 120

gcaaagggca taagatggaa ttcacacaca gtgcaagttg aatttttttt tttttttttt 180

gcctgccaga gtgctacagg taaaacagat tgctactacc cagtgttgct ggtgggctag 240

agtgttcatg tagctttctg caggccagtc tgagaatatt tattaggatt ttaaaagtgc 300

attcattgac cagcacttca cttctgaatt taatgcaagg aaatagttgg gtaaatgggc 360

aaaactattt tgtacaaaaa tattcattgt gttcataata gcaaaaaatt ggaaatcatc 420

caaatgtcat ttgtgttata actccataca ctggaaaagt gagcagccat gaagatggtg 480

tagatttgtt tcaccagcat ggaaaggtgc ctgttacata tttaagtgtg aagatgaggt 540

tgtaaaatgt atgcctggta tgctatgatt tcataagaca cgtggaacta tatcttctta 600

tatgccgatt gatgaagatg gaatcagtgt atataccaaa gagattaaaa gtggttcttt 660

atctgagtga tgattttgtc ttcattgtgt ttagaatact aagaagtttc agcagtggaa 720

tgcctactct tcttataacc ggagtggaaa cggaagcatt ttgtgagagg gctggaggga 780

aggtgagaac gggcgttggg aggcccttcc gtggctccag gcctagggct gcggaaccca 840

caacagaacc cgcaaccgca accgggaacc cgagtgcctg cctagctggg gggccggagg 900

gagggcgggg agggcagcgc cacggacccc agcggaccgg aagggcttgt ggcacgcgga 960

atccccctca gaggccccca gctgccttcc ctgtggcatc atgaagtttc gcgccaagat 1020

caccggcaaa ggctgtctag agctgttcat tcacgtcagc ggcaccgtcg cgaggctagc 1080

gaaggtctgc gtgctccgcg tgcgccctga cagcctgtgc ttcggccccg cgggttccgg 1140

cggcctccac gaggccaggc tgtggtgcga ggtgcggcag ggggccttcc agcagtttcg 1200

<210>55

<211>1200

<212>DNA

<213>智人

<400>55

ggccaagcaa acacccgctc atatttagtg catgagcctg ggttcgagtt gccggagcct 60

cgcgcgtagg gcaggggttc gagcgcccct tctccctgcc tcgcctctgc gcctgggggc 120

tgctgcctca gtttcccagc gacaggcagg gatttcgagc gtccccctcc cctccctcgt 180

caagatccaa gctagctgcc tcagtttccc cgcggagcct gggacgccag cggaggggct 240

cggcgcgtag ggatcacgca gcttccttcc tttttctggg agctgtaaag acgcctccgc 300

ggccaaggcc gaaaggggaa gcgaggaggc cgccggggtg agtgccctcg ggtgtagaga 360

gaggacgccg atttccccgg acgtggtgag accgcgcttc gtcactccca cggttagcgg 420

tcgccgggag gtgcctggct ctgctctggc cgcttctcga gaaatgcccg tgtcagctag 480

gtgtggacgt gacctagggg gaggggcatc cctcagtgga gggagcccgg ggaggattcc 540

tgggccccca cccaggcagg gggctcatcc actcgattaa agaggcctgc gtaagctgga 600

gagggaggac ttgagttcgg accccctcgc agcctggagt ctcagtttac cgctttgtga 660

aatggacaca ataacagtct ccactctccg gggaagttgg cagtatttaa aagtacttaa 720

taaaccgctt agcgcggtgt agaccgtgat tcaagcttag cctggccggg aaacgggagg 780

cgtggaggcc gggagcagcc cccggggtca tcgccctgcc accgccgccc gattgcttta 840

gcttggaaat tccggagctg aagcggccag cgagggagga tgaccctctc ggcccgggca 900

ccctgtcagt ccggaaataa ctgcagcatt tgttccggag gggaaggcgc gaggtttccg 960

ggaaagcagc accgcccctt ggcccccagg tggctagcgc tataaaggat cacgcgcccc 1020

agtcgacgct gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca 1080

gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggtg 1140

agtcggggtg gggattgccg tcgggccagt tctccgaagc cccgggagga ccggctcccg 1200

<210>56

<211>1200

<212>DNA

<213>智人

<400>56

gggagggtcc cacggacata ttgagggacg tggatacgca gaagaggtat ccatgtggtg 60

gcagccggga aggggtgatc agatggtcca cagggaatat cacaaactcg aattctgacg 120

atgttctggt agtcacccag ccagatgagc gcatggagtt gggggtgggg ggtgtcaaag 180

cttggggccc ggaagcggag tcaaaagcat caccctcggt cccttgttct cgcgtggatg 240

tcagggcccc cacccaccga gcagaaggcg gactcagggg cgctccaggg tggctcgagc 300

tcacacacgc tgagtagaca cgtgcccgct gcaccctggg taaatacaga cccggagccg 360

agcggattct aatttagacg cccgcgaacg ctgcgcgcac gcacacgtgt cctcggctcg 420

ctggcacttt cgtcccgccc cctccgtcgc gtgcgggagc tgacccggag gggtgcttag 480

aggtatggct ccgcggggtc aaaaggagaa ggatcagtga gagaggcatc cccacaccct 540

cccctagaac tgtcctttcc ccatccagtg cctcccaaat ctctcttagt ccccaaatgt 600

atccccgccc taaggggcgc tggtgggagg agctaaatgt gggggcgggg ctcggagtcc 660

agcttattat catggcatct cagccagggc tggggtaggg gtttgggaag ggcaacccag 720

catcccccga tcccagagtc gcggccgggg atgacgcgag agagcgtggt cgcccccaga 780

aggccctggg ccatcatgcc ggcctccacg tagaccccag gggtcgctca ctcctgccag 840

ctcgccttca ccaaggccag gagcttagcg cacgctcgcc tcccgccccc ccgccgcctc 900

tgccgccgcc ccctccttgg aaaccaagtt accaacgtta aaccaatccc caagcgcaac 960

tctgcctccc ccacacccca cccgccgcgc cgcgcggagc cgtcctctag cccagctcct 1020

cggctcgcgc tctcctcgcc tcctgtgctt tccccgccgc ggcgatgcca gggccttcgc 1080

cagggctgcg ccgggcgcta ctcggcctct gggctgctct gggcctgggg ctcttcggcc 1140

tctcaggtaa gagccccgct ctggttcggg gtggacaggg cgggggcgga gtccctggac 1200

<210>57

<211>1200

<212>DNA

<213>智人

<400>57

ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg ctgagcggga 60

acttaaaaga ccgcggtgga gaagatgggg cgttctccgc gacactcggc tgcccagagg 120

tgcaaagccg gtgggcgcac gcccggggcg gccctacagc cctcgggccg ccagtctcag 180

ggtgtcgggc tccaactaag gccccgaagc ccccacgcac ctgagggcat tttgaccagc 240

tcttgcgggc tgtcttgcgg ccgcagtggg ttctgaaagt ccattccggc gtagggtgga 300

aaccggcggg aggcgttgct gattctcgat taaacaatag tgacgagacg cgtgcggggc 360

gcctgcgagc cccttcctgc cactcggagc agagcgcgcc agcgcgaggc cgggccggcc 420

gcctgcgcag cgccgggcta attttaactg ttgattacat cttcagcgtg tcctttcata 480

ggtctcattt gtaattgaga cgaatgatta cagtggggcg ggaaggagca gctgctcatt 540

aattaatttc taattaaaag tgcctctcgt tctcgggtga ctaaagagaa acaccgttcg 600

ctgggcgata ttgactcgga tggaatttat ttgctaacgc ccggaggaat ggcccctccg 660

tccaccgcgc ggccgggact gtcctggccc ctcccggcct gagccgccgg cgagtgaccg 720

gcgagtctgc ggccaggccg ggctgcgcga ggtggggctg acgtcagagc ctcctccgct 780

tcaagccgcg cacatctgac ttgacgggtt cgcgcgactc gttttttttt ttttcttttt 840

cgtaaaatat gtatttctgt cgccgctgcg aggccgctcg gtcccagagc cccctcgagc 900

ctccggaatg cgaagttaaa ggaatcgcgg cggccaccgc tgctcacttt gttacccggt 960

tagaaaagtt tgcggagcgc ggggatggac taaccggctc tcctgcttcg ccctcccagc 1020

gcctagaagc ctgcagctcc ggagcagtgg ccgcgccacg ccggccccag cgcgcagaac 1080

cctgcaggcc ccgcccgtcc gccccgggcc gcgcccgcca tgtcctaccc gcagtttgga 1140

tacccctact cctcggctcc ccaggtaagc ggagccccgc cccgcccagg ccaccgcagg 1200

<210>58

<211>1200

<212>DNA

<213>智人

<400>58

gaatcatagt aggtaattga gttatttttt aatttttatt ctgtctttat aagatttttg 60

agaaggtaat caattaacat aaagatctga gcagttataa agatttacaa agaagattat 120

acagtgatgg aaactgaagc atattcttgg caacaatctc aatctatttc acgtttcccg 180

gcttttacat atataaattt ggtatacata atatgtaaat atacttctat tttgcatgaa 240

aactaaaaat actaaaaaag tagcatgagt atatgaaaaa gttaaacatt aaaaatatta 300

gttggaaact ggcttatttt actaacaatt atattcagaa ttctgttgct agactgctgt 360

ttctgggaac attggaggtg tactttctat acttgctaaa atacaagctt ttcaagtatt 420

ttccatagta ttaagtgaga ctttaaatac tcttgctttt ttagatctaa tttctgcttt 480

aatttatcct tctcttcatt tttcctgttt gtcctcatct tacctgttct tccctggttt 540

tactatctcc cagtattcag aaatcagagc aaataattag tctgcttttc tgcagaataa 600

actattgggt atgccatcat gcttttgatc taccacataa acaaattatt ttagcaagac 660

atcactttta tatgctgtat aatgtatgta ttgcttatgt tttaagcaga tttcagctct 720

tttccttcca tcaatttgga attgggggcc caaaagatgt gaaggcgata atgcttccaa 780

gataactggg ctgcatcctt atttgtaaaa taagaaatac tttatttccc aaattttaaa 840

ggagtgttcc ttctccgacc tgttgtgatg gatttattct atagctatgg aaatataccc 900

tgcttcactc ttgtacatac ttctttactc tcctcccgcc aagttcattg aaagagaacc 960

catgtgccgg tccagagcat cgctgcatcc gtaagcagct agacctcagc ttcctctgtc 1020

accatggtgc cggctcggct gggcccggcg gtcgccatgg taactggggc gggtcgcagg 1080

gtcctggcag gctgggcgca tgcgcgcggg gactacaagc cgcgccgcgc tgccgctggc 1140

ccctcagcaa ccctcgacat ggcgctgagg cggccaccgc gactccggct ctgcgctcgg 1200

<210>59

<211>1200

<212>DNA

<213>智人

<400>59

taggggagag ggactcgcca aatccctgtt ttctggggta agcccccctc cccccactct 60

tggacccaag ctgcccggaa ggaagaagga agcattgttt gtcaccggag aaaaccacct 120

gtggtttgca aagggcctca gtcgagtcag gggcaggcgg ggcagatccg agcccggcgg 180

gaggggcgag gcgcgggggc gggcaggggc gagggtaggg gcgctcagct ggcaggtcct 240

gctctgcagg cctcaccgcc cagctcccgg gagggggccg agggcgccct gagtgctgcg 300

cgccttccca tgacgcagtt cctgtgcctt taaatcccac tcccggaggg ggcgggggcg 360

ccccggctgg accccggttt ccagtccggc gggggccccg gggaagccca gggcggggag 420

cgcggggctg ggggcgcgga gggcggggcg cccggggtcc ccgcccgcgc gccgcgccct 480

agcctgctgg gccgcgcccc tcttgggacc gccgcgctcc gggggcgggg gcgggggcgg 540

gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600

gcgccgcgcg gcccgagcgc gcgagccggg cccggagcgc acgccgccgc cgccaccgcc 660

gccgccgccg cccgagccgc cgcattgctg ctgctgctgc cgccgccgcc ccgcgcccgg 720

cccgcggccc ccaatatggt gcagccgcca gcgccgccgc ccgtgccgcc gccgccgccc 780

gcgggccccg ccgccgccct cgggcgcccg cagcgcggca gccgcaggtg gggggccgcg 840

gcccgggcct gagctgcccc ccgcccggcc tcggcgcggc gccctccccg cggggctgcc 900

ggcgaggggc cctctcgccg ctgaggtgga gccgcgggcc ccgccgccgc cgctcctgcc 960

ccctccctcc ctcctcccct ccccctcccc tccggtcctg tctccagcgg gagcgcgaga 1020

cgctggtcag gctccgcggc gcagctcgaa aaggaataat cgcccccgat tgactgaaat 1080

tcctccggag ccggcgccgc ggccgcccgc gcccgagacc gcgctccggg gccgcgtcct 1140

cctctcctcc ggaaaacgct cgcgacccag ggccgccggc ggccgcgact ctgctgtgtc 1200

<210>60

<211>1200

<212>DNA

<213>智人

<400>60

ctttctcttt catcttcctc cctctgccag agccagggag ggagagtggg aggcgtcaag 60

gaggtagggg agagactggc agaggaaaag gagtgggtgg gtgggggcca agtaaataga 120

tacttagatg atgaagtcaa gccactgcgg caatgtttct tgtcagtttc acgcgggcaa 180

agcgtgcctt tcggtgggtt ataagcagcg cccggtccttcctt ctctcg ccaagttgcc 240

tgatccttcc ctccaggcgc gcgcgcacac accacactca cacaccccaa aaccaagact 300

cgtcctacag gatctgggaa aagaaaaaga aaaaaaagcc ctcaatcacc acctccttct 360

cgccgactcc ccctcacccc ccgcctcccc tccagcgggc agccaaggag agctagaggc 420

gggggagggg agagggagga gaagcgacgc aagtgggtag cttttcagcg ccggcgaggc 480

gcgggaggag gagaagcagt ggggaggcgc agccgctcac ctgcggggca gggcgcggag 540

gagggacccg ggctgcgcgc tctcgggccg aggaaccagg acgcgcccgg agcctcgcac 600

gcggccaagc tcggggcgtc ccctcccctc ggccgggcga actcaagggg cgcagctctt 660

tgctttgaca gagctggccg gcggaggcgt gcagagcggc gagccggcga gccaggctga 720

gaaactcgag ccgggaacaa agaggggtcg gactgagtgt gtgtgtcggc tcgagctccg 780

ggcagaggca tttgggcccg aggcccccgc tgtgactccc cgagactccg cagtgccctc 840

cactgcggag tccccgcgct tgccggcaaa aactttattc ttggcaaact tctctttctc 900

ttcccctcct cctcggcccc catcttctgc tcctcctcct tctctagcag attaaatgag 960

cctcgagaag aaaaaccgaa gcgaaaggga agaaaataag aagatctaaa acggacatct 1020

ccagcgtggg tggctccttt ttctttttct ttttttccca cccttcagga agtggacgtt 1080

tcgttatctt ctgatccttg caccttcttt tggggcaaac ggggcccttc tgcccagatc 1140

ccctctcttt tctcggaaaa caaactacta agtcggcatc cggggtaact acagtggaga 1200

<210>61

<211>1200

<212>DNA

<213>智人

<400>61

aatgagaccc agagggtcgg tcctaggaca caattcctct caccctctgc ttctgccacc 60

atcctttccc ctttgccctt ggaggtgctg gaggaggtgg gagtgtcccc gagagtgtcc 120

agactgcata aggtggcaga aaggtgctga gtgtcttcca ttgcaccagt gtcagggact 180

tggatgtggt ccccaggccc aaagccaagg cagatggact catggagggg gaggagcaga 240

ggagcagtgc ggagtcactc tctccatgta gcacccccag ctcagtgcat tgctggggtt 300

cttgcagggc agatgaagtg cttctttgta taggggaata tgtgggtgaa ccaggaaaat 360

gggagcctag tacatggagg tttattccaa ctccctgtgt gattggcaag ttagaattgc 420

ccccctacct gagttattat tggctcctga gaaacaggcc aaaggcagcc cccactaaga 480

agcttttagc acctcctata ggaaggaagc cttcccagtg aatccagtgt gaggattctt 540

ttctccaggt ctctggacct ctcccaacat gctccatgtt cctttgcacg aagaagaaca 600

gcgcagttcg gtagagtgta tgtaagcccc ggttgccatc agcacactgt gtggattctg 660

gcaatacctg tcatccccac tggtgctgcg gtgcccctca tgccccttgt taataaccaa 720

tgatagtgcc acttgaactc ccaggctgtt gtgaggagca agcattcatt cattcattca 780

ttcaatcact catttgttca tgtgacaaat gtggattgaa tgcttgccct ctttcctctc 840

ccctggagcc ttggagagag agataagaca agcgcaaata actgtgacct gttgtaggaa 900

gtgagaaata cacccaggca gggccagata ctgcgtagca ggcggggcac agaggaggga 960

acgcttgtgt ctaactgatg ctcctaatgc ggaagcccct gaaaggcggt tgtggtgcaa 1020

aggaaaaccc acaggccaag gaatgggaag accaaggttg acacttgttt gtcaagtgtc 1080

aataatcatc tctgcccggt gagttgttgc atgaagcaag atcctccttg gggggtgttt 1140

agcacagagg gggtgcgatt ttatttcctg tgaaaatacc aggtagtatt atgttcacta 1200

<210>62

<211>1200

<212>DNA

<213>智人

<400>62

catttcacct atttgactct gcctgcctag agcttgccga gaatgagacc cagagggtcg 60

gtcctaggac acaattcctc tcaccctctg cttctgccac catcctttcc cctttgccct 120

tggaggtgct ggaggaggtg ggagtgtccc cgagagtgtc cagactgcat aaggtggcag 180

aaaggtgctg agtgtcttcc attgcaccag tgtcagggac ttggatgtgg tccccaggcc 240

caaagccaag gcagatggac tcatggaggg ggaggagcag aggagcagtg cggagtcact 300

ctctccatgt agcaccccca gctcagtgca ttgctggggt tcttgcaggg cagatgaagt 360

gcttctttgt ataggggaat atgtgggtga accaggaaaa tgggagccta gtacatggag 420

gtttattcca actccctgtg tgattggcaa gttagaattg cccccctacc tgagttatta 480

ttggctcctg agaaacaggc caaaggcagc ccccactaag aagcttttag cacctcctat 540

aggaaggaag ccttcccagt gaatccagtg tgaggattct tttctccagg tctctggacc 600

tctcccaaca tgctccatgt tcctttgcac gaagaagaac agcgcagttc ggtagagtgt 660

atgtaagccc cggttgccat cagcacactg tgtggattct ggcaatacct gtcatcccca 720

ctggtgctgc ggtgcccctc atgccccttg ttaataacca atgatagtgc cacttgaact 780

cccaggctgt tgtgaggagc aagcattcat tcattcattc attcaatcac tcatttgttc 840

atgtgacaaa tgtggattga atgcttgccc tctttcctct cccctggagc cttggagaga 900

gagataagac aagcgcaaat aactgtgacc tgttgtagga agtgagaaat acacccaggc 960

agggccagat actgcgtagc aggcggggca cagaggaggg aacgcttgtg tctaactgat 1020

gctcctaatg cggaagcccc tgaaaggcgg ttgtggtgca aaggaaaacc cacaggccaa 1080

ggaatgggaa gaccaaggtt gacacttgtt tgtcaagtgt caataatcat ctctgcccgg 1140

tgagttgttg catgaagcaa gatcctcctt ggggggtgtt tagcacagag ggggtgcgat 1200

<210>63

<211>1200

<212>DNA

<213>智人

<400>63

ccaccatgcc ctttgctctc cagggctctg gggccggccc aggtcagcca cttggtggga 60

ttccagcctc agggtggctg agctgcaggt gcagcacccg gcctccaggt ggcaccaatc 120

cgcttacttt gaggtgggct ctgacaacca gctgagctgc ccacagtccc tcagactccc 180

gaggtcctgg gagcagggat caaggtggtc cccaggccgt aaacctgaca gaggctgcag 240

gagtgcattt ccacccaggg tgcactcagc gggtgtaact ccacacccgt ttctttggag 300

tcaaggcccg gcctctcagt gaggagactg ctcctggttg cccaccgtcg ggtcatccca 360

gcctgcagtg gaaccctccg cagcctggcc tcttccaggg tagcccctca ctcccctctc 420

tcctgtccta gcagacaggc cagggagggt ggacgagttc cagctctggg gatgtcccat 480

cagctgtgtc accttgaaca aatcattttg cctcttgggt ctcagtttcc tgcagtgtga 540

aacgtggtgg aggcatgagg ggcaatggga gccccaaggc ctctttcaga gacctcctct 600

gggtcccatg tgacctcgtg gctgtcccca aaggcaagag ggtccccagc cctgcggcca 660

aggccctggg acaccctatc caaacaaatg caggtctctg acgggctgag ctttgctcgc 720

ttgggtttct ttgctttctt cctttttttt ttttctttcc tggatgaaat tcctgccagc 780

tccgaaggaa ggagggaaga ggagcgagcc gcagtgtaga aagtttcctt gactcctcct 840

ccggctgggt ctccctccct tgccaagccc agcctgtgaa actgaataac gaagatcact 900

caacaatgcc tgcccctctc tgactgcacc gtcccggcgc tcccaccgcc gccgccgccg 960

cccaatagag cccctggggc ggtccccacc gacggtgcag cccgccggga ccgggaggaa 1020

gcagctgcgg ccatcgcgcc gtgcgtccgc gcccggccgc caggtgcccc agtagcccga 1080

ccgccgagat gcccagcccg ccggggctcc gggcgctatg gctttgcgcc gcgctgtgcg 1140

cttcccggag ggccggcggc gccccccagc ccggcccggg gcccaccgcc tgcccggccc 1200

<210>64

<211>1200

<212>DNA

<213>智人

<400>64

gctgaagtca cctttccagc agtgtctggt ccagccaggg catcatgccc agtaacagcc 60

ccgatgtcca acacttcccc atgtcctctt ctccccctag acactgccac cttaggggtc 120

ctggctgtta cttcgtccca gggcctgact ggtagtctta gttacacaca caacacaggg 180

gagggaggaa ggagcttggg gcaaagggag ggagtccagc cctttgcctt tccttggaga 240

aggcaaggga gacaggaatg cctttggctg ggagaccctg gccagagatc agaagatcaa 300

aggatgagaa gatcaggggc gaggcaggtg gcactcactt ggaggcacca gagagaagcg 360

gcagctgctg cctcctaagg gcagggctga cccagaacgc cctcctctac ccacagcctc 420

cccagcctat ctttcctaac tttatagccc tgcttctcca ccaggagggg ctctgttggt 480

tacatgcagg tgaggagagg gatgtccact gacattcatg ctacacccat gggttctccc 540

atttaaacct cacaacatta tcttatgggg aatattagat actattttat agatgcagaa 600

actgaggcac agagaggaaa ggaactagtc caatatcaaa caactgctaa gtgttagggc 660

caagatacaa actctggcag tctgacccca gagccactga ggattacatt ataagggcag 720

gcagagaact ctattcagtc caactgcagc atgagggagt gaggctaggt atcaggaagg 780

acttcttgtt gggcaggtat tttagatcca gatcttggat ctagtctttc tatagctctg 840

atgaaccaaa tagttcggga gttagggaag agggcagatg ggtggggcgc tatccagagg 900

gaagggcata cgagagaagc ggcagaacga gagaggatca gcgcggaggg tggcgggcac 960

tggaccgcag aactggcact cgaggtccca ggggccggaa tgcgcttgga gggagagggc 1020

cgctcagcga gggcgggaca gaacctctcc cgggctggga gtgcacggcg cggtgcgccc 1080

aggtaggctt gggggaaggg tgccgagctc cggaaagttc cacaggtcct ccgcagccct 1140

ggggagcagg acccagaaac cgacgcgacg ggtggggcgc tacccgggcc ggccctaatc 1200

<210>65

<211>1200

<212>DNA

<213>智人

<400>65

tgcagcaccc ggcctccagg tggcaccaat ccgcttactt tgaggtgggc tctgacaacc 60

agctgagctg cccacagtcc ctcagactcc cgaggtcctg ggagcaggga tcaaggtggt 120

ccccaggccg taaacctgac agaggctgca ggagtgcatt tccacccagg gtgcactcag 180

cgggtgtaac tccacacccg tttctttgga gtcaaggccc ggcctctcag tgaggagact 240

gctcctggtt gcccaccgtc gggtcatccc agcctgcagt ggaaccctcc gcagcctggc 300

ctcttccagg gtagcccctc actcccctct ctcctgtcct agcagacagg ccagggaggg 360

tggacgagtt ccagctctgg ggatgtccca tcagctgtgt caccttgaac aaatcatttt 420

gcctcttggg tctcagtttc ctgcagtgtg aaacgtggtg gaggcatgag gggcaatggg 480

agccccaagg cctctttcag agacctcctc tgggtcccat gtgacctcgt ggctgtcccc 540

aaaggcaaga gggtccccag ccctgcggcc aaggccctgg gacaccctat ccaaacaaat 600

gcaggtctct gacgggctga gctttgctcg cttgggtttc tttgctttct tccttttttt 660

tttttctttc ctggatgaaa ttcctgccag ctccgaagga aggagggaag aggagcgagc 720

cgcagtgtag aaagtttcct tgactcctcc tccggctggg tctccctccc ttgccaagcc 780

cagcctgtga aactgaataa cgaagatcac tcaacaatgc ctgcccctct ctgactgcac 840

cgtcccggcg ctcccaccgc cgccgccgcc gcccaataga gcccctgggg cggtccccac 900

cgacggtgca gcccgccggg accgggagga agcagctgcg gccatcgcgc cgtgcgtccg 960

cgcccggccg ccaggtgccc cagtagcccg accgccgaga tgcccagccc gccggggctc 1020

cgggcgctat ggctttgcgc cgcgctgtgc gcttcccgga gggccggcgg cgccccccag 1080

cccggcccgg ggcccaccgc ctgcccggcc ccctgccact gccaggagga cggcatcatg 1140

ctgtctgccg actgctctga gctcgggctg tccgccgttc cgggggacct ggaccccctg 1200

<210>66

<211>1200

<212>DNA

<213>智人

<400>66

tttctcagga aaccaaccat cgggcctccc agacagtatc aaggcgctga aactcagtag 60

gtccttgagg ccagacccct caccagtcat gactgcctag ctgcctcctc actctcccta 120

attcctgttt tcccacacag ggtgacattt cttccctgct ctggaaactt ctaattttag 180

tgggctgagg agagggattt gtgactgagc gcccatctct gggctgtagc acttgaatga 240

ggccttcttc cctggcactg ctgttggtga ttggctttct gtgcagggca gggggcctag 300

atgacaaccc tgatgtttgg gtagcactgt cactgtgaga ggcatggaaa tcctccagtt 360

cttagtcttc ttggaggaag gaattcagac aagagatgcc tagcaagagg tatagggtta 420

agtaaccttt atttaaagag tcaggatctc agagagacaa gacagaacct gccactcagg 480

agatagagcc aaaagctagt gacttaggag gaattctttt ctttctcttt ttttttttat 540

ttttttgaga cagagtctcg ctctgtggcc caggctggag tgcagtggcg cgatctcggc 600

tcactgcaag ctccacctcc cgggttcacg ccattctcct gcctcagcct cccgagtagc 660

tgggactaca ggcgccagga ggaattctta tttgagcttt tagttaagga aaacagtaca 720

gcttgaaaga ggaactgctc aaaagaatga gtcagtcgct actcacgctg gggagaccct 780

cttgatgaga gttttacagg attactcacg aacggcccag gcaggggcct tactagtaag 840

cacgttttgg gaagtcctca gggcacgcag gcaccgtgac ctcacacact agtgcgctgg 900

agtgtgtcat tagcatctgg aatctctccc cagggatgtg gtttttgttt tttttttttt 960

ttttggtatt ataatgagct aaaagctatt caggggcgag ttatcagagg tgagcccgtg 1020

ctcttcagcg gagaagatcc cctacctggc cgccggccac tttctgtggg ccgtggggtc 1080

ctcaaggaga cggcccttgg gctcaggggc tgcgtttcca cacgcgcctt tcccagggct 1140

cccgcgcccg ttcctgcctg gccgccggcc gctccaacag cagcacaagg cgggactcag 1200

<210>67

<211>1200

<212>DNA

<213>智人

<400>67

tgttatatgg atgtattgca tagtggtgga gactgggctt ttagtgtagc catcacccct 60

atagtgtaca ttgtacctat taagtaattt gttgtccctc accccctccc tccctcccaa 120

agtgattaca aatattaatg atgacagtga tgacagaaat tctctccaga tgtgatctga 180

gtttggaggg caaagggatt tttgaaaatg aatcataaga gagaaatttt gcaacaaagg 240

agtgtggtac atttaaattg ctgttttttt ttttaaatac tgtgctcacg cggacctaat 300

aaactatcaa gcagacctca tggaattcca cataatgcag aagcgaggga aaaataggta 360

ttgagggaaa agcagcactg ttttcctcaa ttttaacacg tatgtgcagc ctacacttac 420

aaacttaaga cagtagcttt taacatgtga ctttgctcag ggtaacagac cattctggtt 480

atagccttac ttacagctgt ggaggctgaa tcctgatggg tctaagaagt gtcaggacaa 540

gtgttaggga tgcacctgtc tgtctgtctt aagggaatac gggtctgggc agtcttaaat 600

cggagctccc ttgaggagaa tgtcgtgcag tagccttagg aatgtgaaca ttgggagact 660

ggctgggatt ttgtaggtta tgagttgggg acacttatga tagtgaactt gagcccagga 720

gagaagccat aaaaagtgaa actgtcctgg gcacttggag gtgagtgtct ctctagtaag 780

atgcatgtga aaggctggga gctgaaagca aggagagcag aagaggctgg tgaagattct 840

aatctgcgtg tccaggggca ctcttccagg tctcaggaac gcaggtcaga atgtgcaagc 900

cagctgccgg gcacgtggct cacccctgta gtaccagcac tttgggaggc tgagagagaa 960

gatcgcttgt ggccaggagt ttgagaccag actgggcaac atagggagac cctgtctctt 1020

aaaaaaaaaa aaaaaaaagg actgagtgag ccgagcccag tcctctgatg cactgtgtca 1080

ttcatcccct ttcttaggct gtgttggttc taggctagct gctgtctttc tttggtaggc 1140

tgctaacctc tttggattgt gaatttaaaa catgttttac agtaaatttg ctgccaagac 1200

<210>68

<211>1200

<212>DNA

<213>智人

<400>68

gaactgaggg ctcctcccct ttttagacca tatagggtaa acctccccac attgccatgg 60

catttataaa ctgccatggc actggtgggt gcttccttta acatgctaat gcattataat 120

tagcgtaaaa tgagcagtga ggatgaccag aggtcgcttt ctttgccatc ttggttttgg 180

ctggcttctt cactgcatac tgttttatca gtggggtctt tgtgacctct atcttattaa 240

accagtcttg cccaatttct atctcatcct gtgaccgaga atgcggaccc tcctgggagt 300

gcagcccagc aggtctcagc ctcattttac ccagccccct gttcaagatg gagtcgctct 360

ggttccaacg tctctaacgc ggggcccctg actgctctat ttcccaaggt gtatctagca 420

tctcgcacta tacgaggcca agttaaggct tacacatttg cagaaggaaa gaggtaagga 480

agcaacctgg gaccttccac tgtctctgtt tccatctctc tctttccatc tctgttcatc 540

ccagaatctc tctgtcccta tccctaaata tcgaaaattt ctgtctctga ccatctatca 600

ttgtggctga tcatctgttt ctgaccattc cttcccgttc ctgaccccag ggagtgcagg 660

gtgtcctagc caagccggcg tccctcctag tagtaccgct gctctctaac ctcaggacgt 720

caagggccta gagcgacaga tgtttcccag cagggggttc tgaggctgtg cgcccagatc 780

gcgagagagg caagtggggt gacgaggtcg tgcactgagg gtggacgtag aggccaggag 840

tagcaggcgg ccggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900

gcgagtaggg gggtggggca gagaggggcg ggcccgagtg cgccccccgc ccccagcccc 960

gctctgccag ctccctccca gcccagccgg ctacatctgg cggctgccct cccttgtttc 1020

cgctgcatcc agacttcctc aggcggtggc tggaggctgc gcatctgggg ctttaaacat 1080

acaaagggat tgccaggacc tgcggcggcg gcggcggcgg cgggggctgg ggcgcggggg 1140

ccggaccatg agccgctgag ccgggcaaac cccaggccac cgagccagcg gaccctcgga 1200

<210>69

<211>1200

<212>DNA

<213>智人

<400>69

agctcctgct ctccgctcag tcccacagcc ttcccatgca agagttccgc agcttctcct 60

gacgactcct tcccgcaaaa tccccacccc gtccatcagc aacgctgtgg actctctgct 120

cctgcacctc ccttacctcc cttgtcacac ggagaaggaa gagccggaca ggtacccgcc 180

aggagggctg ctctgtagct gggaacctca ctgagtttgc agcaggggcc agaattgtgg 240

ggagccattc tagagaccgc attttctttt tttctttttt tttttttttt atgagatgga 300

gtcttgctct gtcacccaag ctggagtgca gtggcgcgat ctcagctcac tgcaagctcc 360

gcctcccagg ttcacgccat tctcctgcct cagcttcccg agtagctggg actacaggcg 420

cccgccacca cacccggcta atttttttgt attttgagta gagacggggt ttcaccgtgt 480

tagccaggat ggtcttgatc tcctgacctc gtgatccacc catctcggcc tcccaaagtg 540

ctggcattac aggcgtgagc cactgcgccc gaccaacccc attttcttaa tggtgccgca 600

gattgggaag tggctcccag ggcctcagcc tattggcatg caggccaggc agtgcccagc 660

tgagagtggc tcacaaggat gagtcaggag gaaatgagcg gatggcagga gaggctgcca 720

tctgtggccg cctgcatggc caggcctgtt ctcagcgctt tacagcggcc agttcagctg 780

ctctcacctc agccacctcc cgagagacac gtgggaggtg gaggctcaga gaggggaagt 840

caggactaga gcctgggcat tttgataatg acaggagtga gacgcaggtg gagagcaggc 900

caggagcctg cggcgcttct cctgtgagct gcccccagga ggcgctcgtg tgttgcccat 960

cgctcccacc ccttcttccc tccacatctc tagaaataca gacgctgcgt gcaaagcact 1020

gggtgctgat gtggcttagc atctcctgac acctgtggcc tgtcctccct ccagccgggt 1080

gacacccaga cccccagctc ctgcacaccc ctgggcaacc ctgctgtgcc cccggggtgc 1140

tgagcgtggc tttgccagtg tgtcagaggc atcaattgct aaaacaattc ggcagaaatt 1200

<210>70

<211>1200

<212>DNA

<213>智人

<400>70

tatgtcaaga atgaaagatg gctcatcatt atggaccata cagacgttaa aaggataata 60

aggaaatatg ctgaacaact ttatgccaat aatctgacat ctaataattg gatgaaatgg 120

acaaattcct taaaagaatt accaaagttt attcaatatt accttgataa cttgaatagc 180

cctctagctg atgcagaagt gaatttctca ttaaaaacct tcccacaaag aaatctcgaa 240

gcccaaatgg gttccccagc gaatactacc acaattttta gggaataagt taccccatcc 300

tactcccagg tcactgcagg cccggcttaa accgacccca aaccagacag acacagaaaa 360

cgggaggtcg gccacagagc aatctgcttc accagcaccg tccccaacct tggacaaagc 420

gttaccaagc tgagtcaggc aatacaccaa aaggataacg aatcgtgacc aagtgagttt 480

tccaaggaga gccaaacaat gtaattccct atgggctgaa ataaaaagct acaggatcat 540

ttgaatacat gcagaaaagc gttgcagaaa atttcacacc cactcataag aactcttgga 600

aaaacaggaa tagagggaac ttcctcaact tgataaaaaa caccaacaaa aaacgactcc 660

taacatcact ctgggtggtg aaagcgcact tttccctaat gtgtgggcgg caagaaggcg 720

gacccgctcg aagctccgcc cacccacgcg aggccccgcc cgcccgctcg aagccccgcc 780

cacccggcgg tcacaccgcc ttgcgcgctc ggcatgacgt cactcccacc aggcacctcg 840

ccttgtcagg agctgccagg cgccaaccgc cgacctctga ccgctacggg tcccggctcg 900

cgcaacgacc ccaaggcgca tgcccaggcg cggcgacccc attggtggcg ggcggcggga 960

gcggcgcggg cgcgtgcggg cggcggcagc ggcggtgacg gcagcctagg ccgggcgagg 1020

gccatgctga gcctcgcagc caagctggtg gccttcttct ggaggacggc ggacacccct 1080

agggaggaag ccgggcagct ggagcccgag ctcgcggaag gtggctcgcg ggaggcggct 1140

gggaggcggg tcccgggccc tcgcgtgtcg gccacgaggg agccgcgccc ataggtcttt 1200

<210>71

<211>1200

<212>DNA

<213>智人

<400>71

aggccaggct gggtgacaag ccccccgggt ggctgcacct cccactcgcc gacctgggcg 60

ctgtccttgg tgctgccggc gccatagcga gcacaagcgc cttaccttct gcccctgcgg 120

aagctgcgga cgtcccccaa acgttaaaaa cgccatatcc cactttttat acaaataact 180

accccggcct gttctctttg tccccttccc gaagccttca ggcagaccgt tccgcaaagt 240

cttttttttt gttttgtttt gtcttctaga cccagctcct cggcgctcat ctccagctgc 300

tttaagacaa ggggtggggg aaggggaggg aggcaagaaa agatgagggt gggggagggg 360

aaaagaggga atgcaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420

aggatctccg aggaaggggc tgagagaagg gcagggtgaa ctggactaaa ggccagagta 480

ggaaggagaa gaggggccaa aaaagaaggg gatgaaatta agcacagaag atgggtaaag 540

aaaaaagtat cagggaaagg gcaaaataag agaaagcctt gaggataaga gggtagaagg 600

ctaaagaaca aggggaccac tgggtcgggg aagcgctgcc tgaacggcgg gacagtgaca 660

aagaaagggc gctggcgata ttcgcaccaa gggtgcgaaa cgcaatcggg aggtgagaaa 720

tggaaagaag gcgaatgccc ggctacaagt agcctgggac tgaaagggga cctgggggag 780

gggctgggcc cagggcagaa aagtccaggt tcccatgcgg cctgggccca cgtggagcgg 840

gcgctgaatc accgttcagc cgcccccctc ccctcctccc cgaccggtgc ccgcagtccc 900

cgcctcctcg gccgccgcct ccacggggcg gggccctggc ccgggaccag cgccgcggct 960

ataaatgggc tgcggcgagg ccggcagaac gctgtgacag ccacacgccc caaggcctcc 1020

aagatgagct acacgttgga ctcgctgggc aacccgtccg cctaccggcg ggtaaccgag 1080

acccgctcga gcttcagccg cgtcagcggc tccccgtcca gtggcttccg ctcgcagtcg 1140

tggtcccgcg gctcgcccag caccgtgtcc tcctcctata agcgcagcat gctcgccccg 1200

<210>72

<211>1200

<212>DNA

<213>智人

<400>72

agaatgactt ctgtttccct tcctgaaggc ttcttggtgc agtgttgagc tacaggaagg 60

cactagccac atgagcaggg cccttgctga aacccccttc ctccaggaag ccttctttga 120

ctgccatagg ctgcagaggc tcctctcccc caccttgtta tagctaacag aaccactcag 180

ttcagagctg gtggtcttct gatgatctgt cccggagatc tgttccctca gcttggccag 240

agctccaggc ttgtgagtct ggtccgcggg cattcaaagg ccctcagtgg catctgtgca 300

tcagtgagac tgcccggggt tcctgctctg aacccttgcc ctagtgcccc tagcctggct 360

gagaacggag ggtcaagtgc cggggttcta atctcaatta ctttatccaa gcatccgctc 420

gctcatttac atgtttccct gggctctcca ctctgcgcca ggcccggtac ctggagctag 480

ggaaaccgaa cattagtgct ggctcgcccg cccccgcatc cggggagctc ggcgttctcg 540

cggccctgct ccccttgttt tcaagtgcaa gttccatgtt tccgtgctgg gaataaggcc 600

agccccgggt gccaccatac tcgcctgatg tcttaccccg acccgcgccg ccgagagctt 660

gcggctacgg gaacgcggcg cgccccgggg ccacatctgg cctagcgggc gcgcgcgtgt 720

cactaagacg ctcattcacc ggcgcagctg tcaccataac aaccggagcg agggaatcct 780

ggagactgcc ggggcggggg gcgggggcgg cggtcgcagg agggacccgg cgcgggcggg 840

accgcggcgg tcgggggaca ccagctgcgt cggagcgccc agaacgcccc gcgctccgcc 900

gagccccgct ccacgcagac ccgcgggcgg gagggagcca cgcacatcgc cgccgcggcc 960

gtctccgcgg ggcggtaacc gagcctgcct cggagccgcc gaacgcccac gccagcgacc 1020

ctgactctat ggccccgggg gagcgcgccg gagccgccgc gccgcccacc cccagccgga 1080

accctagcgt cccggggagc aagcggggag ccccgggcgt ccccggcccc ggcccagggc 1140

cctgcttgtg gcccccgctc ccgccacggg gcatgggagg caggtagccc agcctgcgcc 1200

<210>73

<211>1200

<212>DNA

<213>智人

<400>73

cccggggttc ctgctctgaa cccttgccct agtgccccta gcctggctga gaacggaggg 60

tcaagtgccg gggttctaat ctcaattact ttatccaagc atccgctcgc tcatttacat 120

gtttccctgg gctctccact ctgcgccagg cccggtacct ggagctaggg aaaccgaaca 180

ttagtgctgg ctcgcccgcc cccgcatccg gggagctcgg cgttctcgcg gccctgctcc 240

ccttgttttc aagtgcaagt tccatgtttc cgtgctggga ataaggccag ccccgggtgc 300

caccatactc gcctgatgtc ttaccccgac ccgcgccgcc gagagcttgc ggctacggga 360

acgcggcgcg ccccggggcc acatctggcc tagcgggcgc gcgcgtgtca ctaagacgct 420

cattcaccgg cgcagctgtc accataacaa ccggagcgag ggaatcctgg agactgccgg 480

ggcggggggc gggggcggcg gtcgcaggag ggacccggcg cgggcgggac cgcggcggtc 540

gggggacacc agctgcgtcg gagcgcccag aacgccccgc gctccgccga gccccgctcc 600

acgcagaccc gcgggcggga gggagccacg cacatcgccg ccgcggccgt ctccgcgggg 660

cggtaaccga gcctgcctcg gagccgccga acgcccacgc cagcgaccct gactctatgg 720

ccccggggga gcgcgccgga gccgccgcgc cgcccacccc cagccggaac cctagcgtcc 780

cggggagcaa gcggggagcc ccgggcgtcc ccggccccgg cccagggccc tgcttgtggc 840

ccccgctccc gccacggggc atgggaggca ggtagcccag cctgcgccag gacacccgtg 900

gcgggcggaa cccgccaagg accgcgaagt ccagagaaag gaagctgagg agctgcccgc 960

ccgcccccgg ctgcagcccc agcagggccc tcccccggtg gcgcgcaccc gcgcgcgcac 1020

actcgcacac cgcacctcag cgcctgcccg gcctcgcccc cacccgcgag cgccgaacct 1080

cctggggccg gatgccatgg gtaacaactt ctccagtatc ccctcgctgc cccgaggaaa 1140

cccgagccgc gcgccgcggg gccaccccca gaacctcaaa ggtaggctcc ccggccgagc 1200

<210>74

<211>1200

<212>DNA

<213>智人

<400>74

tgctcccaag tgcttatgag cccatgtata tgcacatttg tgtgacatga tgcagaagaa 60

tagtgcaggt ctgtgttggg gtgtgtggtg tgtgtgtatg tgcatggtta aagggatagg 120

ttggtgtggg ggggaaaagc ctggattctg gtgctgcact gcctgggttt gcattccagc 180

cttgccacct tttaggtgag cagcctctct ttgtctcagt tttctcatct gtaagaccat 240

catcatcatc ttagagatgg tacctgttga tctgttgata atgactgtaa tactgacctc 300

atcattcagc ctgtgaggac caaaggagtt aatacttgca aagcccttgg aacagagcct 360

ggaagaagac agaaacggtg ttagcacttg gttaacagct ccatcagctt gattgtgaac 420

ctcttgaggg cagggacgat gtctgttttg cttcccaggg ggtcccctct cacctagcag 480

gacctctgca tgtagtaggt gcatgaggct agtgaatgaa tggctgtcgg cctgggcgtt 540

cagggagggc tgtgtgtgtc actacatccc tgagatgggg ctgtgtgtga tggggatgtg 600

tgtgcgtgtg cgcgcctctg ctcgctttct ggagctcgct gctatttcag gaagcctcca 660

gtctcctcct ccttatgtaa ataaacatga cagatcccat cggctgtacc agcgcgggag 720

gtggggaggc tggagtgggt gggagcgggg aggcggcggc cggaggggtg tgcgtgctgc 780

gtgcgcgtgt ggccggctgg ccgcgggcgg gcggcgtgcg cgtgtgccgg agggggcgcg 840

tgggggcgcg tgggggcgcg ggaggggcct cggccctgcc atgccggtct ccgcccgcgg 900

gggaggagac gggggaggag gaggggagca gccggccggg gcgactcggt gaccagccgg 960

ccggcccagc agaggtggct gcactgcccg tcgccggaga tggggggaca gatcacccgg 1020

agcactctcc acggtaaggc cccgcggatg cctgcgggcc cgcccacccc agcccgagac 1080

cgcctgggga ggccgggcgg aggggcgctg gggctgaggg cttggtcatg cccctacttc 1140

tcactccatg gaggggtctg gggctgtgtg ggggcacctt ttggtggtgg gcactggggt 1200

<210>75

<211>1200

<212>DNA

<213>智人

<400>75

gaccgcctcg gcctctcaaa gtgctgggat tacaggcgtg aaccaccatg cccagcctat 60

ccttttgttt tccatcctgt gttggcttgg tgggggagag gaggtgttga cacgtggagg 120

acacacatat aaggcattct tgggtgactt cgtcatcact ggaccctatc tctcaaaatt 180

ccagcgaaat ctgctcttcc ctttaaggag tgaaagaagg gtcagcattc cagaagttcc 240

tggtcatacc caggctttta atgaattgcc actggggaat cagcatcccg ttgctgtaag 300

gactataaga tggcggattg tgagagcata gggaaaggtc tcggaggtct cttgtccttg 360

ctccacgcag gtctttctgg cctgaaaatc ccgttgaaga gagcagctct tgagagtttg 420

ctccaagttc cctcggggtg atcagcacca cggacagcgg ccagggcgcc cccgaggacc 480

cgcaggcagg cagggtgcac agcggcgagc aggtgctgcg ctacgtgcgg gccagggaac 540

tcgcgcgggg aggggagagg cgccgcgggt ggcggggtct tggccggggc tgttttcgct 600

gtgagtcacc ccgtgctccc cgcgctcacg tcggtcctcg gaaagccggg gtcctccctg 660

ccttttccag caacggtggg gtggggaggc aggaagaaag cgccaaccta ggacacctgg 720

acatttgcag gaaaggaaga agcgggagac ggggacttgt ctgtgtctcc agcgcgttcc 780

tgccccccgg cccgacccgg cccatttcta tacaaggtcg gctctgcccg gtctccacct 840

cccacgtcgc aggcgcggag gggctcattc ccgggccctg atctcagagg cccggaatgt 900

ggctgataaa tcagagataa ccctgcatgg cagggcaggc ccgacactca gctccaggat 960

aaaaggccac ggtgtcccga ggagccagga ggagcacccc gcaggctgag ggcaggtggg 1020

aagcaaaccc ggacgcatcg cagcagcagc agcagcagca gaagcagcag cagcagcctc 1080

cgcagtccct ccagagacat ggatccccag acagcacctt cccgggcgct cctgctcctg 1140

ctcttcttgc atctggcttt cctgggaggt cgttcccacc cgctgggcag ccccggttca 1200

<210>76

<211>1200

<212>DNA

<213>智人

<400>76

aggaaagttc tggcatttgg cagattaagc aagtgtcttg atttgaagtc cagtttagtc 60

ccaatactcc ctcccacacc caccacatcg cacaatttgg ttttgtttat ttactccagg 120

ttaaggtaga gtctcttagc ttggtttgag tgctgtactc ttctctctgg tctgatattt 180

ggaactaaag ccaagccaga actccagggc caagggggat gttgaaaatt gtctgagtcc 240

ccagaccacc ctgccagctc atggcaaagg gagggatcag aggccacagg gaaagcactt 300

cagctgctct tcacagcatc accctctccc catttaatgg tttaggttaa caggactttt 360

tccttgaggc ttgggacacg gaagggagcc tcccctaaac caggcccttg gagagcaggc 420

cccaggggag cagtgcaact caccttcaca cccacaagac ggctcctgac ttctgctccc 480

tcctcccctc cccaaagtgg aacagagaga atatgattcc ccacgacttc cacatcacag 540

tttccaaaca atggggaaat cggaggcctc cccgtgtgca gacggtgata tttaccgcca 600

aatgcgaacc aggcagatgc cagccccagc acgcacgcag gtaacttcac cctcgcctca 660

acgacctcag aggctgcccg gcctgcccca cacgggggtg ctaagcctcc cgcccgttct 720

aagcggagac ccaacgccat ccataattaa gttcttcctg agggcgagcg gccaggtgcg 780

ccttcggcag gacagtgcta attccagccc ctttccagcg cgtctccccg cgctcgtccc 840

ccgtctggaa gcccccctcc cacgccccgc ggcccccctt cccctggccc ggggagctgc 900

tccttgtgct gccgggaagg tcaaagtccc gcgcccacca ggagagctcg gcaagtatat 960

aaggacagag gagcgcggga ccaagcggcg gcgaaggagg ggaagaagag ccgcgaccga 1020

gagaggccgc cgagcgtccc cgccctcaga gagcagcctc ccgagacagg taagggcgca 1080

gcgtggggga cccgtgctct ttccccggga tcccctgtcc ccgtcctcgc gatgcagtcg 1140

gccggctccg gctccgaagg cggacctggg cgcctctggc tctccgcggt cccgagttct 1200

<210>77

<211>1200

<212>DNA

<213>智人

<400>77

gacggagctt ggatctctct tgtggtccaa agggaaagga ttgctgaatg taaagccaat 60

gtcaccagaa aagctgaatc cacaagagag tcctggagtc caaaagagca tctcatgggg 120

aatcaggaaa gttctggcat ttggcagatt aagcaagtgt cttgatttga agtccagttt 180

agtcccaata ctccctccca cacccaccac atcgcacaat ttggttttgt ttatttactc 240

caggttaagg tagagtctct tagcttggtt tgagtgctgt actcttctct ctggtctgat 300

atttggaact aaagccaagc cagaactcca gggccaaggg ggatgttgaa aattgtctga 360

gtccccagac caccctgcca gctcatggca aagggaggga tcagaggcca cagggaaagc 420

acttcagctg ctcttcacag catcaccctc tccccattta atggtttagg ttaacaggac 480

tttttccttg aggcttggga cacggaaggg agcctcccct aaaccaggcc cttggagagc 540

aggccccagg ggagcagtgc aactcacctt cacacccaca agacggctcc tgacttctgc 600

tccctcctcc cctccccaaa gtggaacaga gagaatatga ttccccacga cttccacatc 660

acagtttcca aacaatgggg aaatcggagg cctccccgtg tgcagacggt gatatttacc 720

gccaaatgcg aaccaggcag atgccagccc cagcacgcac gcaggtaact tcaccctcgc 780

ctcaacgacc tcagaggctg cccggcctgc cccacacggg ggtgctaagc ctcccgcccg 840

ttctaagcgg agacccaacg ccatccataa ttaagttctt cctgagggcg agcggccagg 900

tgcgccttcg gcaggacagt gctaattcca gcccctttcc agcgcgtctc cccgcgctcg 960

tcccccgtct ggaagccccc ctcccacgcc ccgcggcccc ccttcccctg gcccggggag 1020

ctgctccttg tgctgccggg aaggtcaaag tcccgcgccc accaggagag ctcggcaagt 1080

atataaggac agaggagcgc gggaccaagc ggcggcgaag gaggggaaga agagccgcga 1140

ccgagagagg ccgccgagcg tccccgccct cagagagcag cctcccgaga caggtaaggg 1200

<210>78

<211>1200

<212>DNA

<213>智人

<400>78

ggattacagg catgtgccac caggcccagc taatttttgt atttttagta gagatggagt 60

ttcaccatgt tggccaggct ggtcttgaac tcctgacctc gtgatccacc ctccttggcc 120

tcccaaagtt ctgggattac aggagtgagc cactgcgccc agccacattt aaattttaga 180

gtataattat tgctgcttat aattagaagt gagaagactg ttttgaagta agggacttcc 240

ctggccaccc tcgctaaaat tgcaacctta ccctcactcc atttctcctt ctctgcttta 300

tatttctcca aagcacttat atgataataa actgtataat accgtactta ctgtgtttct 360

catgtatccc ggctacaact gtcaactgcg tgggactggt tttgtctgtt ttgttccctg 420

ctctatccct ggagcgtaaa gcagtgtctg gtatagagtg gatacttaat agatattcgt 480

tgaaccgggc cagtggcggt ggctcacgcc tgtaatccca gcactttggg aggcggaggc 540

aggcagatca cttgaggtca ggagttcgag gccagcctgg ccaacatggc gaaatcccgt 600

ctctactaaa aatacaaaaa ttagccgggt gttgtggtgc atccctgtaa tcccagctac 660

ttcggaggct gaggcaggag aatcgcttga acctgggagg cggacgttgc ggtgagccga 720

gatcgcgcca ttgtactcca gcctgggcga caaagagaga catcgactca aaaaaaaaaa 780

aattcgttga acggaatgag tgaacaaaca aatggatgga tgagtgaatg aatgaacgaa 840

ggaacaagtg accgctcgac cttctacagc gacagcggcg caggcgctcc cgcaccaaca 900

gccccccacc ccgccaccgc cagagggcgc agacaggccg ggtcccgagt gtctgtccca 960

ggcccccgcc ccacaggatc ccggcccggg agcccccgat gcagggaccc gcccgggact 1020

ctgggtcccc gcccatacct caacttcgca cgactgcgtg cctcaagccg acgcagcggc 1080

ctactctcgc actgcagacg gggaaactga ggcctgaggc ggccggggtg gggcagacct 1140

cccggcgagc ccgagccccc gcccccggct agccccgccc tggcccgtaa gaagcacccg 1200

<210>79

<211>1200

<212>DNA

<213>智人

<400>79

aataaacttc catgttgttg ttgttgtttt gaaacggagt gtcactctgt cacctgggat 60

ggagtgcagt ggcacagcct tggctcaccg caacctccgc ctcctgggtt caagtgattc 120

tcctgcctca gcctcctgag tagctgggat tacagatgca cacgaccacg cctggctaat 180

tatttgtatt ttgagtagag atggggtttc accatgttgg ccaggctggt gttgaattcc 240

tgaccttaag tgatctgcct gccttggcct ccccaagtcc tgggataaca ggcatgagcc 300

actgcaccca gccaaacttc gaggtatata attaaaagtt taataagccc tcagcctaat 360

tttaaaattc agattctttc tttctttctt tctttcgttc tttctttctt tctttctttc 420

tttctttctt tctttctttc tttctttctt tcttctttct ttttctttct ttcttgataa 480

cattattatc atagtctggt agattctgtc tttctataat aaaaatcctg tgatgttgtt 540

caaagaaact caatgggctt tctgtatgtt taccaaggaa ttaaaatctt aacaaaggtt 600

ttcaacacaa gaaatactcc cttttgtaag aattcttcat aggtttttct agcacaagtt 660

tgtttttatt gaatgatact tgatggttct gtatgttatt tcttttctac tacatataat 720

tttgattagg ggatacatta aatattttaa aactatcatt tctttttcca gaacaatcat 780

aacatgtttt gcttcttgtt gctttaaaag gaacatttta agttgctttt ttacaacaat 840

aagtgtgaaa ggaaatgcca aaatacaaac aatttcactt cttgttggaa tttgacattt 900

ccactagcta agtaatataa acatgcatca cctaaatgag cagtatttta atagcatcgt 960

tttcacattt taattgttgt cacatttctt ctttgtttag ggagacgtct ggtgaacacc 1020

cgtgggatct aaagaacaag taagatttaa agcatactgg gttgtgtgcc tggctttcac 1080

attttattta ttttattgct taatagtgtt tctttactac tgtgggttgt agcttaaaat 1140

tgttagaaat tttattatgg agtataagga ataaaagtga acgttcaaca ctttcaaatt 1200

<210>80

<211>1200

<212>DNA

<213>智人

<400>80

cctgcctttg catagaattc ctggaatgcc ttttcgtcat cttgttaaaa tcctggttaa 60

acttcaaggc ctagtttgag acactatttc catgatgtca gtcttgatcc tatcttttat 120

agcattatct ggttttcctt cctggcgcta atcacttatt aaattgtact aatcatctgg 180

tgtacctgct ttattttccc tactaatctg gaaacaaaaa taatagaacc tgactcatct 240

ttctgccttg agacaccttg tgctgtcact cttgatgcct tgcacacagt aggtgctcta 300

aaaatagttt gtggcttttt gattttacag agaagactga ggaaattaaa cccttgccca 360

ggaggcatat aaaaatcctg ttaaatgaaa gaggctcatg ctaactattg ttttgactta 420

ttgatgccaa actagacttg aacattgatg tgtcttcagg gaagaagcca aatatgctag 480

tgtaaaaaat tctaacctct gctatttacc tggagaagtt gaattagccc tgtcatttca 540

actgatgcca aaaaagcagc ttccattatt gtgtcagtaa tagactttta tcctgcatgg 600

aggaacttct cttaaatctt tctcatagca ctggtgtgct tctttgcact gatgtattta 660

cgtaatgttt cataagaagt gacagttcct tttttaggtc tttgcccaaa aggtggcata 720

agcaaagaat gaaagtcaag gtggttggct ttaggagagc ctaaaattgg gaatgcgaga 780

gctcccacgt aacacaaacc cggatagtct aagactccta cattttacaa accaagttat 840

ttccttccta atacaaacaa agtatgacag ttacaattta ttgtgtattt acaatggatt 900

gtgtctgtca tggtgattgt gatggaacca ggggggaaag agtaagaaat ctaagcactt 960

ttgtgttttc ttccttttct tttctcttcc tccccgcttt caggctctga aagtgttcca 1020

gctgaaattt cagatcggac agactcgctg cggctccgga ggcagtgatt ccaagctgct 1080

cgcgcacgct gctgccaagc tgcaggatgg tgcacgtagc caggctgctg ctgctgctcc 1140

tcactttctt cctccgcacg gatgctgaga gtaagccatt ctccccttct ctagggggct 1200

<210>81

<211>1200

<212>DNA

<213>智人

<400>81

aagcaaacct agataaatgg gacttcatcc aactaaaatg cttctgcacc gcataggaaa 60

taatcaacaa aatgaaaaaa cagcctatag attgggagaa aatatttgtg agccatatat 120

ctgataaggg gttaatatcc aaaatacatt acgttcacag aactcagcca aaataaataa 180

ataaaacacc cagttaacta acgggcaaag gatgtgaatg gacttttttt ttttttccag 240

aggaagtaca aattgccaac aggtataaga aaaggcgctc aaaatcacta atgaacaggg 300

aaaagccact aggtatctcc tcacacctgc taggatgact gttataaaaa agataagcga 360

taataagtgt cggtgatgtg cggagcaaag ggaaccttgt acactggtgg tgggaatgcg 420

gactggaaca gccattatgg aaaaccctac ggaggttcac tcaaaaagtt aaaaacagaa 480

ctaccagccc agtgttatcc gtccttcgtt aagttcaaag tcacggtgcc acttcctttc 540

ccatctaaag gggactgctc gcgacccaag ccaaggcccg caagtgtggc tctccctgcg 600

gggagagtag ggcaggaggt ggatttccag gccagaggct tccaggctgg gcccggaccc 660

cacgccgacc ccggccccgg ggggggctca gcgacctcgg cgcctcctca ggcccccagt 720

gaacctccgg ggcccataaa ggctccaggc cggctccccg gaggcccacc agcgggcgtc 780

tgggcctccc tccgcgccgc gaccgccagg aggcgccgcc cgggagagga agtccagctg 840

ggcccggccg ggcttcggag gcgccgcccg ggagaggaag tccagttggg cccggccggg 900

cttcagaggc gcagggcggg agccgcctcg cgcagggtcc tccccaagcc ggcgccaggc 960

cctgccctcg tccggccctg ccctcgtctg gccccgcccg ggccgcgagc actggcgggt 1020

tctgggtcct gtgaccggtc aggcggcgtc agcgggcgcg gcggagggct ggccggcctc 1080

gggggagttt ccgcggccgc cgggggcgcg gcggcagagc gcgaggccgg gcagggggcc 1140

agactcggag tcgaggcgcg cccgacagcc gcagcgctca tggcgggcgg aggagccggg 1200

<210>82

<211>1200

<212>DNA

<213>智人

<400>82

agcaaaccta gataaatggg acttcatcca actaaaatgc ttctgcaccg cataggaaat 60

aatcaacaaa atgaaaaaac agcctataga ttgggagaaa atatttgtga gccatatatc 120

tgataagggg ttaatatcca aaatacatta cgttcacaga actcagccaa aataaataaa 180

taaaacaccc agttaactaa cgggcaaagg atgtgaatgg actttttttt tttttccaga 240

ggaagtacaa attgccaaca ggtataagaa aaggcgctca aaatcactaa tgaacaggga 300

aaagccacta ggtatctcct cacacctgct aggatgactg ttataaaaaa gataagcgat 360

aataagtgtc ggtgatgtgc ggagcaaagg gaaccttgta cactggtggt gggaatgcgg 420

actggaacag ccattatgga aaaccctacg gaggttcact caaaaagtta aaaacagaac 480

taccagccca gtgttatccg tccttcgtta agttcaaagt cacggtgcca cttcctttcc 540

catctaaagg ggactgctcg cgacccaagc caaggcccgc aagtgtggct ctccctgcgg 600

ggagagtagg gcaggaggtg gatttccagg ccagaggctt ccaggctggg cccggacccc 660

acgccgaccc cggccccggg gggggctcag cgacctcggc gcctcctcag gcccccagtg 720

aacctccggg gcccataaag gctccaggcc ggctccccgg aggcccacca gcgggcgtct 780

gggcctccct ccgcgccgcg accgccagga ggcgccgccc gggagaggaa gtccagctgg 840

gcccggccgg gcttcggagg cgccgcccgg gagaggaagt ccagttgggc ccggccgggc 900

ttcagaggcg cagggcggga gccgcctcgc gcagggtcct ccccaagccg gcgccaggcc 960

ctgccctcgt ccggccctgc cctcgtctgg ccccgcccgg gccgcgagca ctggcgggtt 1020

ctgggtcctg tgaccggtca ggcggcgtca gcgggcgcgg cggagggctg gccggcctcg 1080

ggggagtttc cgcggccgcc gggggcgcgg cggcagagcg cgaggccggg cagggggcca 1140

gactcggagt cgaggcgcgc ccgacagccg cagcgctcat ggcgggcgga ggagccgggg 1200

<210>83

<211>1200

<212>DNA

<213>智人

<400>83

aagtgcccac ccaaatagcc tcatcattgc tgagggtctg tacatgacag tgactggggc 60

gtaggcagct gcacacacca gggctgagtc ccagcacacg tgttctacct gtgtgactcc 120

gagccttact tttctcatct gtacacagtc tctgtctcaa ggctattgga atgagtcaat 180

gatagagtgc acgtaaatca cttgcacaga gagttgttca aacaatggta gctagaactg 240

ctattgatct attgtggggt aattgtctta actgctttga aggattcagc cctatgtgtt 300

cctttgtcca gtcagatggg aaaatataaa tgagcccttc tcaatgttag gaatgacaag 360

atcaggccaa gacccctctt tctcagacta tccggaagat acacagatga cctggacagt 420

gtctgcaggc tcctgtgtat cctgaggctt cctgagggcc aagttctatg ggtgggaagg 480

cagcttgctc tctaggttgc cataactctg catctgattt gcatgtgttt gtggtgaccc 540

tgcagtttct tctggcattt ccaacttaaa atattgctgt ttccccaggc agggcagata 600

ttgatttttt tcttctctaa ccattccgat tgacccggct cccccaccca gcgaatgggg 660

gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttgcc 720

cttatagcta gcacctttta ctccgtggaa cctgagtcac cggggctgat gagaatgggc 780

tctttccaga agcaagtgca tgatgaagaa agaacagagg gaatgttccc cctcgggtcc 840

atcctggtcc cttctttccc tgcatccctt atatgacctg cagttccctg agtccacttg 900

ccaccggggg cgggtggcac ccaggcggcg gggaggcggg ggaggggcgc agtgacagcc 960

gagccggctt tgaggaacct tgcagaggaa gtggcttcag aactgcttta cgcgaggggc 1020

aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgc tctgcacggc ggcggaggga 1080

gggcgctggc gccggggaca cgaaaccgca gagcccggac gagtcaggga gtgaggcgcg 1140

agccgggcgc ccggggctct gcaggcgcag gcggcgcggg gacaggagca ggttaccggg 1200

<210>84

<211>1200

<212>DNA

<213>智人

<400>84

cttgaagcaa gccttcacgg gggaaagtgc cgggagaaag gagatctctc tttgggtccc 60

atgagtgaac catccatacc aggttccact tagggcattt aggggaactg gtatctccac 120

agtaattact agagcagctc tggggaacgg agggttggct aaggaagaaa agctccccca 180

acccttgggg cgagggagcg ttctctcaat ggagcccccc caactcccct ccacccccca 240

ccagtcttcc aggaaagagg aataccctac ccggcagggc tgcgaaggaa ggggaaatcc 300

aaccagagcg aaagtcgcac gcggacagct ctgccagccc ttggaggcat ccggcggtca 360

cccacgggac aaagcgcggc tgcgggagcg cgcgcggggc attccggacc cgcgtcgagc 420

tccgctctag agggggcggc gggcggcgac aagccggaga gaggaagggc caaggagcac 480

ggccctcctg tcggcaccat cagcgggaga gtggcgagcg gacgcctaga cggaggggcc 540

ctactcagac cccatcgagc cagttcccaa gcttttccct ccgacctgct ccctcccggg 600

gcgcgtgagg gtgcgggtcg ggggtgaacc tggtgttggg gaaagtgatt ggcaagggaa 660

agaggcaggg ctgaaggcct agggcccccc gcagaaatgc gccctctgag ctgtactgta 720

cagaggcgct cctctgcgga atcctgcagc tgctccaggt gaagacgccc ccaaatccac 780

actcgcgcag acgtcgcctg gcacggaccc tacccccttc ggtccgtcgg cggttctctt 840

gggtcgtcct tcctgccact ccgactctcc ccgcccccgc cccgcccagc aggctgcggt 900

tcctttaaag gcgcgctggt gtggggcggc cccttctctc ggggctggct cgggagtagc 960

gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggcatg gccatggcgt 1020

ccccggccat cgggcagcgc ccgtacccgc tactattgga ccccgagccg ccgcgctatc 1080

tacagagcct gagcggcccc gagctaccgc cgccgccccc cgaccggtcc tcgcgcctct 1140

gtgtcccggc gcccctctcc actgcgcccg gggcgcgcga ggggcgcagc gcccggaggg 1200

<210>85

<211>1200

<212>DNA

<213>智人

<400>85

ttcaagatgg tgaccgcaga gcgttaaacc agacaagggt ccatgaaggc ttgaagcaag 60

ccttcacggg ggaaagtgcc gggagaaagg agatctctct ttgggtccca tgagtgaacc 120

atccatacca ggttccactt agggcattta ggggaactgg tatctccaca gtaattacta 180

gagcagctct ggggaacgga gggttggcta aggaagaaaa gctcccccaa cccttggggc 240

gagggagcgt tctctcaatg gagccccccc aactcccctc caccccccac cagtcttcca 300

ggaaagagga ataccctacc cggcagggct gcgaaggaag gggaaatcca accagagcga 360

aagtcgcacg cggacagctc tgccagccct tggaggcatc cggcggtcac ccacgggaca 420

aagcgcggct gcgggagcgc gcgcggggca ttccggaccc gcgtcgagct ccgctctaga 480

gggggcggcg ggcggcgaca agccggagag aggaagggcc aaggagcacg gccctcctgt 540

cggcaccatc agcgggagag tggcgagcgg acgcctagac ggaggggccc tactcagacc 600

ccatcgagcc agttcccaag cttttccctc cgacctgctc cctcccgggg cgcgtgaggg 660

tgcgggtcgg gggtgaacct ggtgttgggg aaagtgattg gcaagggaaa gaggcagggc 720

tgaaggccta gggccccccg cagaaatgcg ccctctgagc tgtactgtac agaggcgctc 780

ctctgcggaa tcctgcagct gctccaggtg aagacgcccc caaatccaca ctcgcgcaga 840

cgtcgcctgg cacggaccct acccccttcg gtccgtcggc ggttctcttg ggtcgtcctt 900

cctgccactc cgactctccc cgcccccgcc ccgcccagca ggctgcggtt cctttaaagg 960

cgcgctggtg tggggcggcc ccttctctcg gggctggctc gggagtagcg cagtcgccaa 1020

agccgccgct gccaaagctg ccgccactag ccgggcatgg ccatggcgtc cccggccatc 1080

gggcagcgcc cgtacccgct actattggac cccgagccgc cgcgctatct acagagcctg 1140

agcggccccg agctaccgcc gccgcccccc gaccggtcct cgcgcctctg tgtcccggcg 1200

<210>86

<211>1200

<212>DNA

<213>智人

<400>86

tactcaggag gccaagacac gagaatcgct tgaacctgag gggatggggg gcagaggatg 60

cagtgagccg agattgccga gatagcgcca ctgcattcca gcctgggcaa cagtgagagc 120

ctccatctca aaaaaaaaaa aaaaaaatgg acttcttcct cattgacctg tggtggctcc 180

aaggccatca aaaaaaaaaa aaatggactt cttcctcatt gacctgtggt ggctccaagg 240

ccatcatctc acagcctttt tttttttttt tttttttgag acggagtctt gctcccttgc 300

ccaggttgga gtggagctgc atgatctcgg ctcactgcaa cctccgcctc ccaggttcaa 360

gcattctcct gcctcagcct cctgagtagc tgggattaca ggcgcgtgcc accacgccca 420

gctaactttt gcatttttaa tagagacggg gtttcaccat attggtcagg ctggactcga 480

actcctaacc tcatgatccg cccgcctcgg cctcccaaag tgctaggatt acaggcgtga 540

gccactgcgc ccggcctcat ctcacatctt tcttcctctg cagcacacga cacgccctag 600

ttggaaacaa agtcggagtt tgtggattgg gggaagggcg gggtctaacc tcaggtcagg 660

cgccgtgcaa ggtacatctt ggcacccgga agaggcccag tacagttgcc cccgaggtga 720

cccgacctcc cctaccaatt gaggcgccct tgttgccagg cttgcggcgg gggagcggcg 780

ggggagcgac ggggatgcgc tcattggtca aggaaggggc gcctgttact agaggcgaga 840

accggagccc attggtcgga acacctcaca atggacccca gcggcgcgca aaatccttat 900

gattggtttg ctggctgcct cgggagaccc tgttgccagg atacttggcg ttcccgaccc 960

gacccccgtt ccccattggc tgtcagggca aaagccgcca tctaatgagg agcgaggtgc 1020

ggtgccccga agcgctcgct tcccgcggtg cgatctagtc ctgcagtagg cggcccgggg 1080

ccacaccgcg gccgcccaag ccagtgcaag gcccaggggc ctgacatcgc tcccagcgct 1140

cgaggaccga ggcctgctgt ggaggacacc gtgctccctc gggacctgct ctggattccg 1200

<210>87

<211>1200

<212>DNA

<213>智人

<400>87

caaaaagcag ccggggatgg ggcgagaaca gaggacttcc ccactgagcc cacatccaac 60

ctcacccaga accccttctc aggtccagtt gctgctccct attaggggta aatgtgttta 120

tgcgcatcat ttccatcatt tctttggggg aaaattggat tctttcctcc tcctcgctac 180

tcgctctccg actctgccag cccatctcct gagagttctc ctgtgtaagg gatgcaaggg 240

ccaccagcac caggtctctg aaaggacgcc ggagccagtt tccggtttcc aagggttgga 300

ccagtgctgg aggggggaat cacaaactgc ccttccagga ccctaccctc tctactaccc 360

caggatgctg aaaaaggcta ttctgcctct cttcccctgc tcagctcttc cccgcctcct 420

gcctccggcc ccagcagagg ccgcgctccc actgcgcctc tcgcctctga gaaatggcgc 480

agcaagcgct ccgcggagag cctggaggcg gggcgccctt ctctgagtcc gcggggtcgc 540

accccgagcc agtcggccag acctgcatcc cgcgtagcat ccctgccctc tctgtgcagc 600

ggaaagggca aaaggcaggg actgcaagcg ggcgcgcacc gggtaggaag agcggctctg 660

cgtaggtgcg cggacccggg ctcctgggtt ccatccccgc cgcgcacctc ggggtccgca 720

cccggctcct gccgggccct tttcggccgc accccgctcc cgcaccccgc tcctccccaa 780

gccccacccg gcccaagccg cgcgtcccgc actgagctcc tacacgcgcc gcgccccggc 840

cgcaccccgc gcagccagag caagcactgg agccccgccc cttcccgcac cccacccgcc 900

tccggccccg cctggcccac ccctggaccg cccccgcccc gccccgcccc tacccgctcc 960

tccggcgcag ccggcgctta cctcgcttca gtcccgcgac cgaagcaggg cgcgcagcag 1020

cgctgagtgc cccggaacgt gcgtcgcgcc cccagtgtcc gtcgcgtccg ccgcgccccg 1080

ggcggggatg gggcggccag actgagcgcc gcacccgcca tccagacccg ccggccctag 1140

ccgcagtccc tccagccgtg gccccagcgc gcacgggcga tggcgaaggc gacgtccggt 1200

<210>88

<211>1200

<212>DNA

<213>智人

<400>88

gacctcaaaa agcagccggg gatggggcga gaacagagga cttccccact gagcccacat 60

ccaacctcac ccagaacccc ttctcaggtc cagttgctgc tccctattag gggtaaatgt 120

gtttatgcgc atcatttcca tcatttcttt gggggaaaat tggattcttt cctcctcctc 180

gctactcgct ctccgactct gccagcccat ctcctgagag ttctcctgtg taagggatgc 240

aagggccacc agcaccaggt ctctgaaagg acgccggagc cagtttccgg tttccaaggg 300

ttggaccagt gctggagggg ggaatcacaa actgcccttc caggacccta ccctctctac 360

taccccagga tgctgaaaaa ggctattctg cctctcttcc cctgctcagc tcttccccgc 420

ctcctgcctc cggccccagc agaggccgcg ctcccactgc gcctctcgcc tctgagaaat 480

ggcgcagcaa gcgctccgcg gagagcctgg aggcggggcg cccttctctg agtccgcggg 540

gtcgcacccc gagccagtcg gccagacctg catcccgcgt agcatccctg ccctctctgt 600

gcagcggaaa gggcaaaagg cagggactgc aagcgggcgc gcaccgggta ggaagagcgg 660

ctctgcgtag gtgcgcggac ccgggctcct gggttccatc cccgccgcgc acctcggggt 720

ccgcacccgg ctcctgccgg gcccttttcg gccgcacccc gctcccgcac cccgctcctc 780

cccaagcccc acccggccca agccgcgcgt cccgcactga gctcctacac gcgccgcgcc 840

ccggccgcac cccgcgcagc cagagcaagc actggagccc cgccccttcc cgcaccccac 900

ccgcctccgg ccccgcctgg cccacccctg gaccgccccc gccccgcccc gcccctaccc 960

gctcctccgg cgcagccggc gcttacctcg cttcagtccc gcgaccgaag cagggcgcgc 1020

agcagcgctg agtgccccgg aacgtgcgtc gcgcccccag tgtccgtcgc gtccgccgcg 1080

ccccgggcgg ggatggggcg gccagactga gcgccgcacc cgccatccag acccgccggc 1140

cctagccgca gtccctccag ccgtggcccc agcgcgcacg ggcgatggcg aaggcgacgt 1200

<210>89

<211>1200

<212>DNA

<213>智人

<400>89

tccccccatg gaggctgccc tctagttcgt cctttagagg aagcatgacc aagggtctgc 60

tggtactttt ctctccctct ctaagaattt cctcaggaga ggaaaaagtt agctttcttt 120

tctctgctcc tgagtgccat ggcctgcagt acgtgaccag tccttggcac agagtcactc 180

agggctcatg gtagatgctt agcggtcaca gccagtagct gcgcagtgtg gcagcagctg 240

agatccatac tgcagcctga aagttgtgtt tcagcttctg aggttacaag tgtatccagt 300

gtttacatca gagataaagc cccctttccc ctctctccta cgggagccct caacaagaca 360

gatacacggg ttgggtggag tgagaccaca tccagcagag gcaaagcttg ctaaaagaga 420

gaggaggagg agggggagag ggaggaggcg gcacggcgtc ccttggcagc tccgtgcatg 480

ctgcggcagt tgcaacagga gaaccgagta ccagttgctc aacactttat cactttgcat 540

tgctctttct cctcccttaa gtgaatttcc attttgaggg tacagctcca caggagaaag 600

gtgtggtggt ggtagtggtg gagggtgtct gtggggggga tggtggtgcg acgggagttg 660

gaatgtccag tgtggggaag caaaggagtg cctactagga tgcgaatacc acttggccct 720

gggctcgctc cgctttagcc ttcccctctc gctggggaga aacaggcggt ttgtgaggga 780

gactgagaga ggggcgtgtt tgtggtggtg gcggcccatc gggggtcctt gtcctctccg 840

aatacccgga ctgctgaggg gaagggccgg gggggccccg gcggttgcca tggtgacgca 900

gggtcggcgg ctcagcgccg tagagacaaa gccgcccgcc cgccagcccg ctagctcctc 960

gcgcgagctc ctcctccacg ggaacctccc tcccctccca ggcgccgccg cagccggagc 1020

ggctcccggg ccctgggccg ccgccggcca ggtaaggcga tcgcgcccgc ggccggggag 1080

gggtcggcgg gacgccgggc ctccccaacg ctggggcagc agccagcccc gcagtcctgg 1140

acggcgccgg gccgcccaag cgcgccgagg agagggggcg gcaaacttcg ggccgagcgg 1200

<210>90

<211>1200

<212>DNA

<213>智人

<400>90

gagggagaga tgcagggagc tggattttag ctcctaaggt agaaaatttc caaaaggctg 60

atcaaagatt aaatggctgc cttaaaaggt aatgagttcc ttgttagtgg aggtgttcaa 120

ccactgcttg gtgggaagac actgtaagga ggattcaggc aagtgggaag ggggcttttt 180

ccagtccctg aaatcaatga ttctaacagg aaaagatgct ccggggtgcg gtgagcgctt 240

acctctgctc ttgcagagac actgacagac gttcattcaa catctgttcc tgccaggcac 300

tgtgcgcgct gaacacagaa gtacagcctc tatgaagcag ccgctgtagg cctcagagac 360

agctgataga tgtaacactg ttgtctccat gtttcaaact tcggtcatgg tcttactagg 420

tctcctcatt aaggggactc actatgtgtc cagtaacgct ttcttgttac cagatgacag 480

agagtcaggc tgtcagagtt cacgacttta ggtgcacagt ttcaccctgt ctggtccttg 540

ggagacggag aaggggtcag gagaaaacgt gggtgaagag gcagcaaagc cgcaggagat 600

atgaactaat tgctcaacgt gggtgtagca cggattaggc cttttacagc aagcgctgcc 660

agcagggaac tggtggatgt actcttgacc acgctcggct ggactctggg gagcccaaga 720

cgggtaagac taggtccccg gccccagcag ctggtggggg cgccgcaggt tagagacgtg 780

aggccgcgag gctgagggct gtgaaggcgg tgggcacgca cggcgtgccg gggccgcctg 840

gcttcgcggc gggggaggta acactgcgac accccgcaga cgctgtcagc cggggtcgcg 900

gccccgcgtg cgcccgatca tctgactgct ggggagtgcg ggggcgcggg agccaggcga 960

gccagcgcag gcgcgcgctg cctcctccgt ccccaccgag tccccagcgc gtgcgcgggg 1020

ccgtggccga ggcctgcgcg ccgcccggcc gcctgcactg cgcgcgcgcc caccccgcgt 1080

gggaggcagc gggaggggcc cggagaggtg tggagcggcg cggcgggagg ctccgtgggc 1140

ggccacggga gacagcgccg gcgggagcgc gcctctcggc ctttcctccg cgcccccgcg 1200

<210>91

<211>1200

<212>DNA

<213>智人

<400>91

ttagctccta aggtagaaaa tttccaaaag gctgatcaaa gattaaatgg ctgccttaaa 60

aggtaatgag ttccttgtta gtggaggtgt tcaaccactg cttggtggga agacactgta 120

aggaggattc aggcaagtgg gaagggggct ttttccagtc cctgaaatca atgattctaa 180

caggaaaaga tgctccgggg tgcggtgagc gcttacctct gctcttgcag agacactgac 240

agacgttcat tcaacatctg ttcctgccag gcactgtgcg cgctgaacac agaagtacag 300

cctctatgaa gcagccgctg taggcctcag agacagctga tagatgtaac actgttgtct 360

ccatgtttca aacttcggtc atggtcttac taggtctcct cattaagggg actcactatg 420

tgtccagtaa cgctttcttg ttaccagatg acagagagtc aggctgtcag agttcacgac 480

tttaggtgca cagtttcacc ctgtctggtc cttgggagac ggagaagggg tcaggagaaa 540

acgtgggtga agaggcagca aagccgcagg agatatgaac taattgctca acgtgggtgt 600

agcacggatt aggcctttta cagcaagcgc tgccagcagg gaactggtgg atgtactctt 660

gaccacgctc ggctggactc tggggagccc aagacgggta agactaggtc cccggcccca 720

gcagctggtg ggggcgccgc aggttagaga cgtgaggccg cgaggctgag ggctgtgaag 780

gcggtgggca cgcacggcgt gccggggccg cctggcttcg cggcggggga ggtaacactg 840

cgacaccccg cagacgctgt cagccggggt cgcggccccg cgtgcgcccg atcatctgac 900

tgctggggag tgcgggggcg cgggagccag gcgagccagc gcaggcgcgc gctgcctcct 960

ccgtccccac cgagtcccca gcgcgtgcgc ggggccgtgg ccgaggcctg cgcgccgccc 1020

ggccgcctgc actgcgcgcg cgcccacccc gcgtgggagg cagcgggagg ggcccggaga 1080

ggtgtggagc ggcgcggcgg gaggctccgt gggcggccac gggagacagc gccggcggga 1140

gcgcgcctct cggcctttcc tccgcgcccc cgcgtcccca gccggccgct ccgagaggac 1200

<210>92

<211>1200

<212>DNA

<213>智人

<400>92

acaaaaaaat tccaatagtg attagtaaca accagatact gtgacagtgc cccattgcca 60

ttccatggga gatgcaagag cattgtctca gtaataaaat atgatgttat caggcattta 120

tggctcctgg ggaaaaaaat gcaattgctt gctgttttga tattatctct gactatgctt 180

gcttatcatt tgccatttct atatttagta gccagtcatt ttgaagttaa aaaaaaatca 240

aggtttgcat tgtaaccaca aaccagtctt tgtgaacagg aatcctggag gctattaatc 300

agcttttaaa ggaggtaagt catggtggtg gtggggtatc tgaaattttg gaagttccga 360

gctcacttta agagttgaga tgggtgggag ggctgaaaac accaccattc atcattcttc 420

agttatctcg agactcaact taaacatttt taatcaaaaa gatgggaggg gacacgggtc 480

acatctcagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaactgagc caaaatattc 540

cactgtgaag agatctccct tctcggctgg tggacatcaa ccttaccaag taatctttgg 600

agcaagtaac taccaaataa agccgttcca aaacttctac gtaagctcct actttttaat 660

gagtacgcat ttctccccat tttcttttcc tctccaagga ctgagatagc tggagcaagg 720

atgggtcccc ctctgatttc gtccccgccc cagccaatct gagcccggat gctaattagc 780

tgcgctcccc tgatgaacac gcctttgtca caagtaggcc cggactacaa agcccagaat 840

gcctcacccc tccctgatca atgagggctt atttaaatga tctctgaggt cttggaccca 900

ggccaatcag ctgtcagggc tcatgataaa tcgcaatgca ttattgataa taataattac 960

tgggacatgc gcgttccggc cgaagggggg taaatttccc aactccagga atttgtggcg 1020

gagagggcaa ataactgcgg ctctcccggc gccccgatgc tcgcaccatg tcgaggcgca 1080

agcaggcgaa accccagcac atcaactcgg aggaggacca gggcgagcag cagccgcagc 1140

agcagacccc ggagtttgca gatgcggccc cagcggcgcc cgcggcgggg gagctgggtg 1200

<210>93

<211>1200

<212>DNA

<213>智人

<400>93

tgtaacatgg acctctctgt gacgcgcaag tattatctgg cagttacatg gtgccgcctg 60

tgcagctggg cgccaccacc agcttcctgc cctgtgcgat taaaaggcca gcttcgggga 120

cagcagcctc ctcaacgcaa agcgaccagc cctgccaggc gtcggctgca gctggtccaa 180

ggttgacggt cccagggccg cattctcctt ccggtcacct cagactctgg aaagagagcc 240

atggagggcc tcagagcgcc cctctgcagt tccttgagga aaacaagggc ctccccctct 300

tggctggagc agccaagtgc ccacggggaa aatggtcccg tccaccattt caggcaaacg 360

cccccatagc tgtaataaac atgtgatggg tttcctgcac caagaaagga aaattttcct 420

taaaaataac aaaaagaggt ggggagggga ctctaagttc catttaagat tttccaaact 480

cgttgtgtct catgcatacg ctgaggctta acatgaaaat ttggagcgaa agtccccacg 540

gttcaccaca gggaatgaag taaagtatct cgccggtagc tctaggtctc gtaaaccgtg 600

gagctccttt agtataaggc cctattatgt gccacattag atgagaagaa aataagagga 660

aggatacggt agagccttta gaatggggtt cagtcttagg actcgtagga taaaggaagg 720

tcgtttccct ccgtttgagg cagggaatca aacaaaacac cggcaccgca ggcaccgcag 780

tcgcactcct ggggcctcgt ggctttcccg cgcgcccgcc ttgggggcgg ggaagaaccc 840

ggatggaacc acccttgcag cccggacccc ccgccgtctt tgaatggcag cggggcggag 900

ttgccctccc ttctgtgctc tgactggttt ggctccgcac tctcctcttc gtgattgggc 960

tttcctagtg ccagtcacag agcgacgctg gtctcccaga ttgttgcaga aggagacggc 1020

gtcgacgtct gactggactc gcggcgactt acctttcagt cgtgcgctcc tgatccggcg 1080

ctcggaattt gtccccggct tcagggctgc ggggcctgga aggaggcgta tcgaggcggc 1140

tcgaaaacga tccaggggag ccgaggcgct cctcttgtca tcccactcag cgccatgtcc 1200

<210>94

<211>1200

<212>DNA

<213>智人

<400>94

tttaaaagtc ccactgaaaa cttttttttt ttccagatcg aaacacaagt ttaatagtca 60

ttcagatttc attccagtct aaagaaactt atagaaatct aattatctgc cagaataacc 120

gctttaaact gactgtaaga accacagtta ctttgcagct aaaacagatt gttctcttcc 180

cccaaacaaa ctcggacatt tagacaaata ttgctgctgt ctttacattt tagaaatcag 240

tattaaggct cacctgttac tgaacacata cgagaaacag ttttgttatg cgtatcttat 300

atacatcatg tatacatttt cgtactttca catgatgtgt ataataagat acacataaaa 360

actggttggc ttgtcatgag taaatgcttt attctttaga gtgaaggaat attggataca 420

gaacgtcgtt ccatatttaa tcttgcttta gaaaattagg atttatcttg gacacagcat 480

tttgaatata acacaggcaa gttgagtcct gggggaaaaa ttgtattttt aaatttatta 540

tcaacggtgt ctttcgcatt tgagaaaaca catttgaaga tgcccatgca gttccttgga 600

agtaaactag gtcacccacc actgaaacac cctcggcttc tgcaaaaaga tgtgctttaa 660

agagaataga atggacgctc ggtatgttca tctaaacgac cttgggcaag tacgtcgatt 720

ccaaggtaca atcagccctc ccagacggct tttcgagtct ccctaacccc ggtgggagag 780

gacgcggcgc cagagcccag ctccggctag ttttcccggg ggcaggtgta gccttgggcg 840

cggggccggg ggaggggcaa ggggcgggcg tggggttgga ctgggacgtg ggactcggac 900

cacggcctgg gcgtgggcct aacgacgcgg gaccggcccg ccctcgccgc tccattggcc 960

acatctgtgc agaaaaggcc ccgcggccca ggggcgcccg cagtgtcact aggccggctg 1020

ggggccctgg gtacgctgta gaccagaccg cgacaggcca gaacacgggc ggcggcttcg 1080

ggccgggaga cccgcgcagc cctcggggca tctcagtgcc tcactcccca ccccctcccc 1140

cgggtcgggg gaggcggcgc gtccggcgga gggttgaggg gagcggggca ggcctggagc 1200

<210>95

<211>1200

<212>DNA

<213>智人

<400>95

tgttctccag agcaggaaac aagcttggag agtgcgataa ctagcccaag cttcacaatg 60

ggtgagtggc aggactgagg tttgattcgg gtctcttccc agagagacac tgggagagat 120

tcttgcccca ggtcttttcc cttcaggccc tcaggctcag cacctctctg aacatctgtc 180

cctggggagt gagaatctga actaaaatgt aagccaagaa aacacaggct cttcattgaa 240

tctttggaaa ctcctttcct gggctgtagg aggaccttcc tgagccttag gcacttttgc 300

ctttgctggc tctttcctcc aagtcaagca tattttatga ctgtggaggt ataaatacaa 360

atatattaac attatatagt aaaacatttt gtttgacata aattttttct tctgattttt 420

acagaaaaca ttttcataga tctccaaaag tatcgtgggc cctaagcgct gtagctaagt 480

cgtttctcct ttctcagcct ccagtctgac atgttccact atggccttgg gaagagcaat 540

gggcccggag tcgccgcatc taaccctgct gtaactggtc gcaagtcaca gtttgctcat 600

ctataaagtg agcgaaagta atgtaatctt tattgggagt agggaacatg aaggcgagtc 660

gatacagtaa gtaagccgcc aagcatattg ctaggcacag agcaggtgtg caacaaaagt 720

tatttctcag gctttccctc ctctgagcgc cgtcctccag agggtccgga gtgtagctgg 780

gggttggagc agcagcctcc taggcgatgg gacagagccc acagggtccg gtatgccacg 840

gtttcttcgt cagaccctgg gaatccaacg tcgcaaaata aacacggccg cgccgctaat 900

cgccagttcg gaggaaacaa aacagcgctg cgctggggga tctgggcaaa atcagccctc 960

cctcctcccg ctccttcgcc gcggccctcc cctcctcgcg ctgctctcgt tcgcttggct 1020

cagctcagct cagctcagcg cagctccgcg gccgccaagc cgaggcgggc acggtctccg 1080

agtcgcggac gccagctccg agctccctct ctccgccgcg cctccgccag gtcgcgcctt 1140

cgtcgggacc acttcgggca ggagtcgcgt ggcgaaggcc tgcggccgcg gcacaaagtt 1200

<210>96

<211>1200

<212>DNA

<213>智人

<400>96

agagggttca agtttagatt tcaggctaaa cttctgggct tagagggtcc tgagcatggg 60

actggataaa ggagggaagc catcatctct tcagaagatg ttcagaaaag ggcatacacc 120

cagtctatct gagctgggag agagctgctg ttatgccctg gggcaggggg atggatgaaa 180

tggcatttga gggctcagat tctctttggg gcaagacctg acttcctatg gactcccagg 240

agcagcaggg gagttctgag aggaactgtg attgtccaga gtggagtttc tttgagactt 300

gccctgtacc taaccccaaa cagatttgat acttagagac ctctaacccg gcatctcatt 360

gtacagctgg gaaaactgag acccaggagg aaggggcctc tccgagatgc cacagtgagt 420

caagagtcct cacttcagag ggctggagaa taatctactg aggcagggcc agggcacctg 480

tctgagaggg gcttctaagg ctgcaagctt ttccccttcc gtggactgca ttcacacctt 540

gttcggtcct gctggggccg gggctctcct tccttgcccc ttttccttgg cactctttcc 600

acaggccctg tgtggtctgg gctctaccga gaggtcccca aggagagctg gcgtgtcagt 660

cagccaagaa gcaagcaggc aggcaatgcc agcatgcagg tggcggggct ggcaggggag 720

ccggcaggag ggccggacac ccggagccgg ggaactgtaa tgttcaggga atttcaattg 780

gcattgctgt cccgttccag ccaactggct aacggtgccg agtttgaatc agtgacccgc 840

ctcctggtcc ctcctcctta gccggcctct ctccctccct ccttttttcc ctccctcggt 900

ggccttccag gaggcgggag gcgcccgctg tcgaggcagc tgagccccgg caaccgctgc 960

tctccgcctc tcccctcgcg gggccggctc atggagcgca gggaccgggc tggctctcgc 1020

cgagccccgg gcctctttta gcctcgtccc cagagaggga ggagccggtg cccggcacag 1080

ccccgccggc cctagaagct ccccacgcgc caccatgcct ctgctggacg ttttctggtc 1140

ttgcttcagg aaggtgaagg taagtgactg gccagcccca gcccatcccg ctgctcaggg 1200

<210>97

<211>1200

<212>DNA

<213>智人

<400>97

agtgtgagac cagcctgggc aacatagcaa gacttcagct ctacaaaaaa tgtaaaaatt 60

agctgagcat ggtggcacac acctgttatc ctagctactc aggaagttga ggcaggagat 120

tttcttgacc acaggagttc caggctgggt agctttaagt gagtcatgct taaagtctgc 180

tcagtttctg tctttgtaaa tgtgagggat agcagttgaa ctgcatgagg tcctggatac 240

tctcagacct gactaatagg agtcctcaat tcaacaatga aatcaaggtt gtgaacttgt 300

gttggaccct tgtgatgaaa ggccagagag aaatcaaagc cgaaggctct tgtttcttac 360

tgaatttgaa tggactttct ggtggtgctt actatcagaa ctcctggaag ccctcccctg 420

ccacgattaa tgttcgtgcc ccaaattttc catgcatttc tctgcggagg tagagttcag 480

acttggggta ggggacagaa gcctggggta ttggggaagt tgcagagcca ctggggcctg 540

agcaacgtag ggatggcagc ttcctgctca aattcctaat tatctggttt tcccctacca 600

attggagatt tcactgaagt tgtgtcttct ggacatccca taaattatcc gagcaagtca 660

ctgaaccctc ccgggcacat agcatatgtg tttaaatccc ccaaacagtg ccggactcat 720

tcagaactca ataaatatta gcctgtgtgc ctggccaagt cactgcttga gcctcagtct 780

ttgggcttgc acctcctccc tggcagcggt gtgaccggag ggaaaggcag cggcgagggc 840

cttggaggac ctgcaggcag tgccccgccc acccagattt gggtgacttt ctggcgagtc 900

cggtgggcca gactgcgccc ccattggccg aggggaggtg ggcggggcgt ccctacagcc 960

ctactcgccg acgctccctc cccacttgag ctgagtggac tcgggttgac aacggctaag 1020

cagccgcggc agctgctctt ctggctggca ccgtcacccc tgcccgaccc caggccccgc 1080

gtgtgtcccg gacggagcag tccctcctgg gctcgcctcc tgcccgctcg ctctgtgtca 1140

gcgcccgaac ccaaaggggt ggacgcggcc tccaggtagg agtctgggcg acggcagggg 1200

<210>98

<211>1200

<212>DNA

<213>智人

<400>98

gggctgagag agggggaggg tcactgcttc ttaatggctt tctgcccaga aagcctctag 60

aactgcctgc tgctgacttt ctttcctttc agggcatcca gagggttcaa gtttagattt 120

caggctaaac ttctgggctt agagggtcct gagcatggga ctggataaag gagggaagcc 180

atcatctctt cagaagatgt tcagaaaagg gcatacaccc agtctatctg agctgggaga 240

gagctgctgt tatgccctgg ggcaggggga tggatgaaat ggcatttgag ggctcagatt 300

ctctttgggg caagacctga cttcctatgg actcccagga gcagcagggg agttctgaga 360

ggaactgtga ttgtccagag tggagtttct ttgagacttg ccctgtacct aaccccaaac 420

agatttgata cttagagacc tctaacccgg catctcattg tacagctggg aaaactgaga 480

cccaggagga aggggcctct ccgagatgcc acagtgagtc aagagtcctc acttcagagg 540

gctggagaat aatctactga ggcagggcca gggcacctgt ctgagagggg cttctaaggc 600

tgcaagcttt tccccttccg tggactgcat tcacaccttg ttcggtcctg ctggggccgg 660

ggctctcctt ccttgcccct tttccttggc actctttcca caggccctgt gtggtctggg 720

ctctaccgag aggtccccaa ggagagctgg cgtgtcagtc agccaagaag caagcaggca 780

ggcaatgcca gcatgcaggt ggcggggctg gcaggggagc cggcaggagg gccggacacc 840

cggagccggg gaactgtaat gttcagggaa tttcaattgg cattgctgtc ccgttccagc 900

caactggcta acggtgccga gtttgaatca gtgacccgcc tcctggtccc tcctccttag 960

ccggcctctc tccctccctc cttttttccc tccctcggtg gccttccagg aggcgggagg 1020

cgcccgctgt cgaggcagct gagccccggc aaccgctgct ctccgcctct cccctcgcgg 1080

ggccggctca tggagcgcag ggaccgggct ggctctcgcc gagccccggg cctcttttag 1140

cctcgtcccc agagagggag gagccggtgc ccggcacagc cccgccggcc ctagaagctc 1200

<210>99

<211>1200

<212>DNA

<213>智人

<400>99

tggggagggg ctgagagagg gggagggtca ctgcttctta atggctttct gcccagaaag 60

cctctagaac tgcctgctgc tgactttctt tcctttcagg gcatccagag ggttcaagtt 120

tagatttcag gctaaacttc tgggcttaga gggtcctgag catgggactg gataaaggag 180

ggaagccatc atctcttcag aagatgttca gaaaagggca tacacccagt ctatctgagc 240

tgggagagag ctgctgttat gccctggggc agggggatgg atgaaatggc atttgagggc 300

tcagattctc tttggggcaa gacctgactt cctatggact cccaggagca gcaggggagt 360

tctgagagga actgtgattg tccagagtgg agtttctttg agacttgccc tgtacctaac 420

cccaaacaga tttgatactt agagacctct aacccggcat ctcattgtac agctgggaaa 480

actgagaccc aggaggaagg ggcctctccg agatgccaca gtgagtcaag agtcctcact 540

tcagagggct ggagaataat ctactgaggc agggccaggg cacctgtctg agaggggctt 600

ctaaggctgc aagcttttcc ccttccgtgg actgcattca caccttgttc ggtcctgctg 660

gggccggggc tctccttcct tgcccctttt ccttggcact ctttccacag gccctgtgtg 720

gtctgggctc taccgagagg tccccaagga gagctggcgt gtcagtcagc caagaagcaa 780

gcaggcaggc aatgccagca tgcaggtggc ggggctggca ggggagccgg caggagggcc 840

ggacacccgg agccggggaa ctgtaatgtt cagggaattt caattggcat tgctgtcccg 900

ttccagccaa ctggctaacg gtgccgagtt tgaatcagtg acccgcctcc tggtccctcc 960

tccttagccg gcctctctcc ctccctcctt ttttccctcc ctcggtggcc ttccaggagg 1020

cgggaggcgc ccgctgtcga ggcagctgag ccccggcaac cgctgctctc cgcctctccc 1080

ctcgcggggc cggctcatgg agcgcaggga ccgggctggc tctcgccgag ccccgggcct 1140

cttttagcct cgtccccaga gagggaggag ccggtgcccg gcacagcccc gccggcccta 1200

<210>100

<211>1200

<212>DNA

<213>智人

<400>100

aacaattcaa aactggaagc agtccaaaca cctattaaaa ggtagataaa caaattgtgt 60

tatattcatg cagtggaata gtaacagcaa taaaacccaa caaactcttg acacatagga 120

cgaaatttat caatcaaaat aattatgcta ttggaaagaa gctagattaa atgttcatac 180

tgtatgattc tattatcgta aaattctaga aaatgcaaac taatatatgg tgacagaaag 240

cagaacggga gctgggagga gtcaggtatt acaaccgggc atgaggaaac tttgaggtga 300

tggaaaagtt tatcttaatt gtggaggtga tttcaacagt gtatacatat gttcaccctt 360

aacaaattat gcacttttga tatctgcagt ttattgtact ttaaccttca agctgttaaa 420

aattaaccgg agataatttt caattgttgt gtaaggtttg ccacaaagtg taatatctgc 480

aaagaagcag acaactaatt ttttcttctt aagattgtgg aaaaagttgt aatactacag 540

agagctgtgg aatctaagga ttagttgacc aacgcttgta aagctaccaa tctgaaaaac 600

acattttcag ttaccaaagt tattttctct cttccatcgt gtaaatagaa tgtcggggtt 660

cttctaattt gggtgtttct aaaatttaaa tccacgtgaa cagattagga aagaccacga 720

aatcctacgt cacctctaaa gtcacagctt gaagccttgc gaaaggaact ggccctagac 780

cccaccccgg cctataaatc accagggcgc agcctcagtg cctgggggtc ggcagcagcc 840

agcgtcaggc ggctcccgca cgcttcttcc taggcggcag gccgtggctg ccacgtgact 900

cccgctaaca ccggatgatg gcgcagcgct gtgcacgcag gcgcagtgtg gggcccttgc 960

ggtcgaagct cacgcggtaa gccgctgcac gtgtgctacg gcgggcggag ggccgaaagt 1020

ccagtatgtg ggtccagggt cactcttcta gagcttccgc aacggaaagt gtgaggtcag 1080

tagtagtttt tgtggtacgt gcagtggtgg ccgcttcaag gactattttc gtcgctgctt 1140

gcgttttaag tctccaatcc tgggacgagg cccatttcag ggttttctgt caccttctag 1200

<210>101

<211>1200

<212>DNA

<213>智人

<400>101

catcctcatg tcgtgtcccg ccagcaacta taatttcccc gcgtgactga gcgccctgct 60

agagttgccc agatttagcc agaatctggc agaggcggcc ccaaaatttg gaactcccag 120

gcctcagggg ccacctctcc agcactgcgc gcttggagtc ggggtggaca ctgtcattct 180

ctctcatcga ttgattgatt gagacgaagt ctcactctgt cgcccaggct ggagtgcagt 240

ggggccatct cagctcactg caacctccgc ctcccgggtt gaagcgattc ttctgcctca 300

gcctcctgag taactgagat cataggcacc cgccaccgcg cccggctaat tttgtatttt 360

tagtagagac ggggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg 420

atccacccac ctcggcctcc caaagtgatg ggattacagg catgagccac agcgcccggc 480

catttctgtt gttgtttttt ttttttgaga cgaagtttca ctcttgtcac ccaggctgga 540

gtgcagtggc tgcgatcttg gctcactgtg acctctgtct cccgggttca agcgattctc 600

ctgcctcagc ctcctgagca gctgggacta caggcacgtg ccaccacgcc cggttaattt 660

tgtttttttt tttcagtaga gacggggttt catcatgttg gccaggctgg tcttgaactc 720

ctgacctcag gtgatctgcc tgcctcaacc ttccaaagtg ctgggatttc aggcgtgagc 780

taccgtgctt ggcctattta ttttattatt ttttaacaaa tgtcattatc ttcttaactt 840

ttggcccccc aaataaatga ggaaactgtt aaaattgtat tcaacaatcc ttgttcgata 900

tctcctttga tatttaaact tttaccagtg tattaaaatg atgtctttgc attcagaagg 960

ttaaagaaat ttgtttttta aagtcaggaa gcatctaaat atggtgtcct ccggaaaaaa 1020

gtattccagg aaatctggga agccgtctgt ggaagatcag tttacgagag cctatgactt 1080

tgagactgaa gataagaaag atctgagtgg atcagaggaa gatgttattg aaggtgcagt 1140

acatctcatg ttgggcagtg atgtccttca gttcatttgt tttgaaccca ttgagactat 1200

<210>102

<211>1200

<212>DNA

<213>智人

<400>102

aaaaaggctt agaggagttt gtgtgctcaa ggtcattacg ttagttaatg gagaagatag 60

gattcaaact cagctgtcta cacaaccatc tataatgagt attctgtaaa tatttaataa 120

gtgaatttct ctacacacat tgcttgtatc tttgctggaa cacaaggagt gcagtaaata 180

cttaaagata gtgaagtcag ggaaagccag gagggcttgt aactaatcgc acatcgctgg 240

tgtgaccagg tgtttcaatg ccaaagcagt taaaatgtgt cttgtcaaca tcatttgaga 300

tttttagtat ctattattca cttttaacca tggcttgttt tgctgttctt actgattttt 360

ttagatccaa gacaaaataa aagaagttga gcagagcaag gccacgagcc aggaactcag 420

ccggcaaatt cagaagttag ctaaagacct cacaactatt ctaactaagc tgaaagcgaa 480

gacagataat gtagttcaag ctaaaactga ccaaaaggta agaagtagaa ttttaaaggg 540

tactactgaa tgaattaaat agtttttgga gtcagtttta cttggggata taggataaaa 600

accttttagg aacctttttt aaaaccaaat agtaacagca ggtggtaaag aaattttgta 660

actgaagcaa cacagatcct cttacataat tgatcattat aattgaacag tattaataaa 720

tatacatgca tgagtgtgta cgaaagaaga gcgtcaaagg actaagtgat gatttaggaa 780

tacaagtata taaattccaa actgaattgt gtccttggta gctaaatctg tgttcttcct 840

ctgttgatga gttcagggac tctaatcctt tttgggtggg gcagaaggaa aatgttagcc 900

ttctcactca gcctcatagg aaataaacac cagcattaca acatatcctg ccctgccttt 960

ccaaccgaag aaacaaaaat gacctgatca tagtagaatt atagtagaat tattcattat 1020

aatatttggc tttgacaaaa atcagtctga tctcgggaaa cctggagaaa tttattttct 1080

gtactctaat gttctttcat tttggtgacc atcaaggtgc tgggagagga attagatggc 1140

tgtaattcaa agttaatgga attagatgca gcagtacaga aattcttgga acagaatggc 1200

<210>103

<211>1200

<212>DNA

<213>智人

<400>103

agggctgacc tggaataatt atgctctggt ggttgtctcc acaaggggct ctgggggtgc 60

cccaggattg ttgccctcag gcagaggcag ggcatacatt gagagtgatc ccaaacactc 120

ctcctccagg cccaactttt ggaggtagca agttctgcaa atagagatcc attgtttggt 180

ttctctctct aaaaaaaaac aaaagtcagc acaaagaaga ggaacacatc agattggttt 240

accagatttg tttcagatgt tattattttg acacgatcca gaagaaggag aatttgaaga 300

aaatggaaag ctaggcagtg ggaatgttgg cagcaggtaa gggaaaggca ggcagcaaag 360

agaaacttca tctactttat aaactgctcc ttcctttcag caaatttaga ggataaatga 420

ctgttttgtt cagattggag attcaagggg gggattatta cttttaagat tattgcaaca 480

tggcttcgat tattttagct gcaatcatcc tgttggactt ggacttcact gttggtgaag 540

agagactgtg tttgactttg cctggatacc ataaaaccac aacaaaataa attctcctga 600

atgctaccag gcaacaccaa gatctcttac accacgagaa ggacttgtgg ccaaagatac 660

aaatggctcc gcaatgtaca gggtgcatac agtgcacctg aagaacctaa aagtggtttt 720

tagaatcatc ataataaaca gtcaagaatt aaagatgtca agcgctttct caagaagtct 780

aaactttata cataacatta aaaaagatct ataaagcctg accagtctcc ctcaaattaa 840

gttatttgct actgacttgg cagccaaaac gatttaggat ctttcggaag ttgatgaaaa 900

aggagccagc gggttttgct ctttgctctg catcacgccc ttcctgggac catcagggaa 960

cctcccagcc tttcaggata ggttccgctc agaaaggtca cccgggcagt ggaaaccgtg 1020

ggcaaaagtt agctggcagg acagcgcagc tcctccaggc agcggaggca gcgcgtcccg 1080

gctctcaggg acatttcctt cccacctcga cccccgggag gtggtcccgg tataaaggct 1140

cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg agaaacgccc aaggccgtgc 1200

<210>104

<211>1200

<212>DNA

<213>智人

<400>104

atatttatta acatcacatt taatcttctc actgtgttac ctatggggta ttccctgcac 60

ttgtttgaaa ttttctaatc aaaagggtat ttcaaaatat attgtaatat gattgattta 120

ctttagatgg caagcaaata ccactttata atagtctgca tgcattcaaa gtaaaataac 180

agtagaaagc ctaatctctt ttgccattaa aggtttcaat ttgtcatgct cagttttaag 240

cttttaaaaa ccaacatatc cagaaaggca aaaaatacta aaatcatttc atagcagtaa 300

ttacattttc ctttggatca tgtgccttta aaacgtctga atgcattgct gtgcaagtgt 360

catgtgtgtt taaaagatgc ataattatta gatgcagttc cagcatagtg ttttaagtac 420

aagcacccag ctcctattca aggtaagagc ctttgacagg caccaagctg cctctgaatg 480

tggcagcggg atcaaattgt tgaatacatt gactcatcgg tgcgggctgg aaattatgct 540

tcttagccct ctgtgaaaca tgtttttcat tttttatttt tttttaaact gtatcttagg 600

atctgcttca aaacacggat gcccacaaaa gagcattcca tgaaatctac cggaccaggt 660

ctgttaacgg gattccagtg ccacctgatc aattagagga catggccgag aggtaagaga 720

atatctgcat ttaaaggaag tctcttttta aaacactagg tggacgcttt ttatatttct 780

tttatttttt catgattttt ttttaacaga ggcgcctacc tttggtaaat agaaagcggg 840

ctcccataag acatgctaag aatgccacca ttctaatgta ttattaactg aaaagagtga 900

ctctgaattt atccacagcc tagaaatcac agaaatggtt tcttcagagg ctgtattttt 960

gttcagtact gtaaggaaca ttatgtaata ttgcaaaaac agcttataaa agaaacagac 1020

gagagatgtg ttggcagggg aaagaactaa atcgaagact tcaatcattc atgctttgct 1080

tttaaatcca gagctagaaa aggaatcgga tttccagaaa atgatcagcc agagttagaa 1140

gagcttgtgg ctgcattcta tttaaggctg acatgtaaca ggttaagtaa gcatcagttc 1200

<210>105

<211>1200

<212>DNA

<213>智人

<400>105

attcaatgtc tcccacttta taatagcaaa tcctagactt caggaaacag tgggctaaaa 60

agatgtatga ctatcattca ttttagtcct agtttatttg ctattttcct tggagtgtgg 120

tcttctctct gataatcatt ttgcctattc tcccatttta aacttttcag ctctccttaa 180

ggcggcagca aataggtgaa agattgaatg aatgggcagt cttcagtgaa aagaacaagg 240

aactctgtga gtggttgact caaatggaaa gcaaagtttc tcagaatgga gacattctca 300

ttgaagaaat gatagagaag ctcaagaagg tatggaatgc atggctactt aggttttcat 360

tcttcataag gcttatgtgt acttttcaca ggtacagaag gtggctttac tcacaattac 420

tttcctgtca aaggagcagt atattttaaa cattttatct ttttaatata aaataaactt 480

gcagctgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggct gaggtgggca 540

gatcatgagg tcaggagatc aagaccatcc tggccaacat ggtgaaaccc tgtctctact 600

aaaatacaaa acattagcct ggcgtggtgg tgcgcgcctg tagtaccagc tactctagag 660

gctgaggcag gggaatcact tgaacccaga aggcggagat tgcagtgagc cgagatcgtg 720

ccactgcact ccagcctggt gacagaacga gactctgtct caaaaaaaaa aaaaaaaaaa 780

aaaaaaaaaa aggatatcca gcataaaata aacttgcata aaaaggcctg ctttacacat 840

aaaatatata gaatacttgc aatttgtgat gaaatagagc atctactatt cagttcagta 900

tttgggggtc ttaattacct gttcagtagg aaccctttat atgtattatt tttctttcct 960

tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaagcca ctagagagaa 1020

actgaaagaa aacattctta agataaattg aattgacatt ttctctctaa aatatgattt 1080

atagaccaca gataggaatt aagagtttcc tgataatttt ggcttcatat tattttaaag 1140

gtatgtatat cttatcaaat tattttacat attcatttgg atccaaaaca tttctgatgt 1200

<210>106

<211>1200

<212>DNA

<213>智人

<400>106

tgaccttgtg atccaccaac ctcagcctcc caaagtgctg ggattacagg cgtgagccac 60

caatgtattt cttttattaa gaaaatgtgt ttcctgtagt gttctgtttt aaaaacagtc 120

aactcacatg accagaacca gatgctttgt tttattttag ttacaaatca tcatgtagtc 180

ctttttggaa agaacttagc aaattttcat tatttattta atatttatta tttatttgtg 240

tgtagttttt aatcccctaa aggatgtaaa gcatccagca ttaatcatat tttattgaat 300

tataggaatt aataatttgg ggacttattt tctttaaaag tataaattat taaattatca 360

tctgcttagt gcagaaagtt tggaaactct tgaaattcac aaaagaaaaa gagttacctg 420

aagaccccct gagcaaatga atatagttat ttttttaatt gtcttaaaat gaaaatgtta 480

tttttgtcat ctacatgatt atttttaaag gacaaaagtt ttgcatatgt aagggagaat 540

aatatttctt ccttattttt cctccccaaa tagtctactc aaagataaag agcatgtact 600

ttcccacctt cgcaaacaac ccctaaaact cttgcataca ctaccgagct ggcatactga 660

acccaaaaaa gaaggaagtt actccttttg ctactaccat ttgctgtgtt tgtggacatt 720

ttgtttgttt gcagtgggat gatttgtttt ctttaaatag ctttcccagc ataacaaact 780

gcccgcaaga aaagttgact gtccttacag aacagcagag tgtgtgcagc cgatgttgtt 840

tttgctgtcc tttctttaga cctgtagctt cctcctcctt acagattaca ctgagctttt 900

tccccttctt acactcgtgg cctacattcc aggagatcaa gcctggcaca tgttaatgaa 960

tgtaggtttt atttagaaac atgaccactt gtcactgccc agtgtcatgt tatcgggcag 1020

agactaccaa catttgtcta cagtgagcat tttcatactt ctatacacag acaaggggaa 1080

actttcatcc ccacgcagga tatagctttt tgctctgcag agtctaactt ttgcaagtgg 1140

aagcttcatg gtggtggcgg aggacctgag tgccctgagg atggcagagg acagctgtgt 1200

<210>107

<211>1200

<212>DNA

<213>智人

<400>107

tgccttgtct catatttagt tcattggaat acatatatta tgctaacaat aataagcatg 60

aaaaaaattt caaatttttt aactccatga ggtaaactaa ataaggtaaa agaaattaaa 120

ctaaggaaat tatgacaata aaatgttttg aagacttcag gttttttaaa atgttagtca 180

taatcaagaa aaaaacaaag ttgcctatag tggtagattc ataaccaata tatttcttta 240

atcaaagttt aaaatatttt catttctgat tactaaaaat acattaatat aagaagaatg 300

attgttttat aaaagaattc acagtacaat atctttaagt actatgtttt ctagaattta 360

tttcttatat aaaatgcagt tttctttaat tttttatttt tttttttgag attgggtttg 420

cgctgtcacc caggctgtag tgcactggtg cagtaatggc tcactgcagc ctcagcctcc 480

tgggctcaag cagtcttcct cccacttcat tacctgggac tacagatgca tgccactgtg 540

cctggataat cttttgattt tttttttttt ttttttttga gatgaggtgt cactttgtaa 600

cccaggctgg caggtgtatt tccttttttt tttttttttt ttttgagatg gagtctcgct 660

ctgtcaccca ggctggagtg cagtggcgcc atctcagctc actgcaagct ctgcctccca 720

ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg tgcccgccac 780

cacgcccagc taattttttg tatttttagt agagacaggg tttcacagtg ttagccagga 840

tggtcttgat ctcctgacct tgtgatccac caacctcagc ctcccaaagt gctgggatta 900

caggcgtgag ccaccaatgt atttctttta ttaagaaaat gtgtttcctg tagtgttctg 960

ttttaaaaac agtcaactca catgaccaga accagatgct ttgttttatt ttagttacaa 1020

atcatcatgt agtccttttt ggaaagaact tagcaaattt tcattattta tttaatattt 1080

attatttatt tgtgtgtagt ttttaatccc ctaaaggatg taaagcatcc agcattaatc 1140

atattttatt gaattatagg aattaataat ttggggactt attttcttta aaagtataaa 1200

<210>108

<211>1200

<212>DNA

<213>智人

<400>108

tgtttgactt tgcctggata ccataaaacc acaacaaaat aaattctcct gaatgctacc 60

aggcaacacc aagatctctt acaccacgag aaggacttgt ggccaaagat acaaatggct 120

ccgcaatgta cagggtgcat acagtgcacc tgaagaacct aaaagtggtt tttagaatca 180

tcataataaa cagtcaagaa ttaaagatgt caagcgcttt ctcaagaagt ctaaacttta 240

tacataacat taaaaaagat ctataaagcc tgaccagtct ccctcaaatt aagttatttg 300

ctactgactt ggcagccaaa acgatttagg atctttcgga agttgatgaa aaaggagcca 360

gcgggttttg ctctttgctc tgcatcacgc ccttcctggg accatcaggg aacctcccag 420

cctttcagga taggttccgc tcagaaaggt cacccgggca gtggaaaccg tgggcaaaag 480

ttagctggca ggacagcgca gctcctccag gcagcggagg cagcgcgtcc cggctctcag 540

ggacatttcc ttcccacctc gacccccggg aggtggtccc ggtataaagg ctcgctgagc 600

gggtgggtca cagcacagct ttgcagctgc ggagaaacgc ccaaggccgt gcatctccag 660

gaggtaggga agcctgcgag cctccgggtc cccgccccca gctcttccag gcaccggcgc 720

atcccggagc cgggcgcggg gcgcggggca cggagccggg gagggggtgt ggcgggccag 780

ggcggtgcag ggaccctgcc cagaggctga accggcctgg gcgaccttcc ttcccgacag 840

gagcagtaga tgcgtggggg agggcgaagg gggaggcctc accccccagc gagcagccgg 900

gaggaggaac cggtcgcgga gggcggggag cgcggctgag cagcccggcg cgggagtgag 960

tgtgggcgag ccagccaggg tgagcgcggg cgccgggccg cggccgccgg ccgcagcggg 1020

ctgagattgt tgtcctctgt caccagggcg gctgggctcc cgcagtcctg cagaccgcgc 1080

ccgatcccgg cgacagggcg ggcggacagc cgcgcatccc cggggtcccg ccgagcctgg 1140

gcgcagagag ccgggaggaa gcgttcgctc gcttcgcctt gctgctggga aactgaacga 1200

<210>109

<211>1200

<212>DNA

<213>智人

<400>109

tgttttattt tagttacaaa tcatcatgta gtcctttttg gaaagaactt agcaaatttt 60

cattatttat ttaatattta ttatttattt gtgtgtagtt tttaatcccc taaaggatgt 120

aaagcatcca gcattaatca tattttattg aattatagga attaataatt tggggactta 180

ttttctttaa aagtataaat tattaaatta tcatctgctt agtgcagaaa gtttggaaac 240

tcttgaaatt cacaaaagaa aaagagttac ctgaagaccc cctgagcaaa tgaatatagt 300

tattttttta attgtcttaa aatgaaaatg ttatttttgt catctacatg attattttta 360

aaggacaaaa gttttgcata tgtaagggag aataatattt cttccttatt tttcctcccc 420

aaatagtcta ctcaaagata aagagcatgt actttcccac cttcgcaaac aacccctaaa 480

actcttgcat acactaccga gctggcatac tgaacccaaa aaagaaggaa gttactcctt 540

ttgctactac catttgctgt gtttgtggac attttgtttg tttgcagtgg gatgatttgt 600

tttctttaaa tagctttccc agcataacaa actgcccgca agaaaagttg actgtcctta 660

cagaacagca gagtgtgtgc agccgatgtt gtttttgctg tcctttcttt agacctgtag 720

cttcctcctc cttacagatt acactgagct ttttcccctt cttacactcg tggcctacat 780

tccaggagat caagcctggc acatgttaat gaatgtaggt tttatttaga aacatgacca 840

cttgtcactg cccagtgtca tgttatcggg cagagactac caacatttgt ctacagtgag 900

cattttcata cttctataca cagacaaggg gaaactttca tccccacgca ggatatagct 960

ttttgctctg cagagtctaa cttttgcaag tggaagcttc atggtggtgg cggaggacct 1020

gagtgccctg aggatggcag aggacagctg tgtggatgca gatctcccag attgtaactg 1080

cgatgtcaca aggcaggcat cttcttgagt ttcttccatt gtacatagct ttcatgttac 1140

g1ggggtttg taggatagac gctggaagcc ttaatccaga actgtttttg ccaatgttac 1200

<210>110

<211>1200

<212>DNA

<213>智人

<400>110

ggagagaccc gaaggggagc ggaggttggg gtagaagccc ccggccctcc tgtattacta 60

ctgcggaatg cgggggaccc cgcagacagc caggctccca ggacggggca cccttggggc 120

ttcagtttcc ctcgcatctc caagctcgct ctgcgggcga tttgccagga gaggggtcca 180

tggagagagc gggagacgag gggcgcccgg ctgaggaata gggcttgcct cctagcgagt 240

gtcgaggtcc ccgggtccgt gcgtcggtct gtccgtccgt ttgtgtgttc tcgcggtgaa 300

cgcgggcgga cccccagtct ctccgggaga aacttgggtc tgcggctggc acgaggtctt 360

tgtgtccggg tgtctctccg gctgcgagtg gttttccgcg tctccgctgg ggggcggggg 420

acagggggcg gggtggggga gggtatgagg gtgttgcggc gtccttcccc caccccctct 480

cgcccctata actcgctccc tccgtccctc tcggactcgg actcggggcc ggtgcgcgac 540

tgagctggcg cctctagccg actttgccaa gagggcgcct cctgcccgat ccgcgctgac 600

cctgcgcggg acgcagcccc aggcggctgc ctagccgagg cgggagcccg agctgagtcg 660

agctcgccgg agcgggtgag tcccgagccc gatccccgcc gggctggacc ctggcgcgca 720

gctgcggcgt ctccggggag tcgcggcagg gggaatggcg tgtcgcgccc tggcggcggg 780

agctgcggga gggtcggcga cgtggcggcc ggcccagggt atttacctgc tgcaccagtg 840

cccggcagcc acgctcgccg gctgccgcgg ggcttctttg tcccgatatc tggagggtcc 900

ggggcgggag ggagtactgg gtcgcgtccc ctccatgggg gaggggctgg gggagtgaga 960

ggcctggaga taatgcggag tgggggtggg gagatcctgc aaggaccagg acgccggggt 1020

tccaggagac tctgcaggct ccatccctcc ttattccccc accccgaccc cagtagcgct 1080

gggcctagga gcactcggga gttgctcagt ggctctgcac cgctggcgcg ggaaggggag 1140

aaaggggctg ccagaggcgg gaatttggtc cccacgcgct gctccaggga cgagaagcca 1200

<210>111

<211>1200

<212>DNA

<213>智人

<400>111

ggggccccac cgccgacagg tgtagatcaa gagactcccg agataggccc ctgcagggcg 60

ctggtccccc ggcctccctg accatggctc acagacttcc agcgctgagt gaggcagctc 120

gaagcctctc agccgatctg ttcctgggcc tcactccaca gtttctgagg ggatctctac 180

tttaagtcta gcctcaatcc tcccgttgag ctttctgtct ttcttgttat gcttagcaga 240

aagatacatg atctctggtg ctgtttcacc gaagcaagga ggtgggtcgg cggaactgag 300

cgccctgcgc cctcttgaaa tgacccccca ttcctgtttg ccagaaactt ttccctcccg 360

ttgccatgga gagagacggc cgctgcctcc cgtcgccata gcaacatgcg ggtaccgcgg 420

accgcaggat tgcggagctc ggaaagtctt gcagttcgca tcgcccgcct gtcttggggt 480

cttctacctc cgaagctggg actcgggggc cagtctaact gctcccgtca ggaacctcgg 540

ccaaggtcct cccagaccct gcctgaccgt cgctctttct gttacggggt tatctatttc 600

tctgtcattc gtgtggcatg tggcagttta cccagtgttt tcacaaacac gatctttcta 660

tccccaggga gtccgtgaag tacttaaaat cattacacct cctttacgga gaggaaaatt 720

gaggctcaga gacgcccaag gtcacaccag gcagtgaatg cggagtggga acccggactc 780

tttcctggcc ttgcaccctc cgagattcgg gacagcccgg cttcccgcct cgaaaccccc 840

accccccgga ctcaggccag tccctgagtg tagagggggc ggccgcgagg cgccagactc 900

gccagctgcc gcgggatgcc acgtgagggg cggggaccct gcggggaagt gattaaaagc 960

agagcggagc cgcagggggc cgctgcaggg agggtcttct tggggccgtc gtgccccgcc 1020

ccagtgcggc cggggcgcgg gttcgagctg ctgctcggca agcctgggtg tctagggcat 1080

gagcggagtg tggggggccg gcgggcctcg gtgccaggag gcgctcgcgg tcctcgcctc 1140

gctgtgccgg gcccggccgc cccctctcgg gctggacgtg gagacttgtc ggagcttcga 1200

<210>112

<211>1200

<212>DNA

<213>智人

<400>112

aactgggaaa gagctggaag atgagacacc aaactccatc ccatggtgatgt ttgaacca 60

ggctggagct ggtttcacat gtttttcatt gtgcatgact ttcttaattg ccttagtggg 120

aatgcgttac tgcaaaataa agtgaaattg ttttccttat tgcttgtaat ttacagaggg 180

gtggttttga tcatataaac caggcacttt tcaaatccat tgatcttagg gtggaaggag 240

ggatttcttt ttaagtattc atttcgaact atgctttcac tagtaaactc aaagcccaag 300

ggcaaaaacc catgattctc cattttgtaa tagctattag atgtccacag cacatcagac 360

ctgtggaaaa cgcatgcttt gtgtatggaa gagggagagg gagcgtcagg agttgtcctt 420

tgccaaaaaa cgtactctga cactcaaagg cacaggctgg tggagatcca gggaacccgg 480

gaaagcccag gcctaactca ggcccgcgcg ggtctcttct gatcccataa gatgaggagt 540

gggtcctggc tctgggcatc ctggtgtcga ctgtgagttc ccagcagagg cccagagtcc 600

cggtccggca gccgagggaa gcgggggggt cttccagaag aagaaagggc caaggtcacc 660

ccggtgcctc tccagcagca gcagagggcg gcggtcggtg tcgctgctgg ccggggcctc 720

gaggaaggcg cgggccagct ggggccgggt ctgcgttccc aggagctgcc accgttccag 780

ggagcaagtc aggccgggac gtagcgcctg cgcgggaccc tcacttgcca ccaagacccc 840

cacaaacccc gccccatcct gccttacgcc ccgccccaag gtcgttctcc cgacccgggg 900

tcccgcccca aggccgtcct cccgccccgc cgcttggtgg cggccgcatg ctgcccggat 960

ataaagggtc ggccccacat cccagggacc agcgagcggc cttgagaggc tctggctctt 1020

gcttcttagg cggcccgagg acgccatggc cgagtgcccg acactcgggg aggcagtcac 1080

cgaccacccg gaccgcctgt gggcctggga gaagttcgtg tatttggacg agaagcagca 1140

cgcctggctg cccttaacca tcgaggtaca gccagctttg gagcggatgg cgaggcagca 1200

<210>113

<211>1200

<212>DNA

<213>智人

<400>113

tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60

tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120

tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180

ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240

tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300

attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360

cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420

ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480

tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540

ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600

ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660

agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720

caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780

ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840

aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900

cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960

gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020

ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080

ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140

cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200

<210>114

<211>1200

<212>DNA

<213>智人

<400>114

tctaatctat ggtaatcgaa atgagaagag tgtttgcccc tggcctaagg atggaaggat 60

tgatttagga aaaagtctgc aggagctttc tggagtgatg gaaatgttct aactcttttt 120

tttttcttct tcttcttctt tttcttcgtt tcgagacgga gttccactct gccgcccaga 180

ctggagtgca gtggcgccat ctgggctcac tgcagcctcc gcctcctggg ttcaagccat 240

tctcctgcct cagcctcccg aggggctggg actacaggtg cccgccacca cgcccggcta 300

attttttgtg tttttaatag agacggggtt tcgccatgtt ggccaggcta gtctcgaact 360

cctgatttca ggtgatccac ccgccttggc ctcccaaagt gctgggatta caggcgcgag 420

ctaccgcgcc cagccaaaat gttctaattc tttattggtg gctacacagt tgtcaaaatt 480

tatcaaactg tccacctacg atatattata agcctgtatt aaatgtaaat tagaactcga 540

ttgaaatctg tgtgtataaa tataaatata cacttattta catttctaat ctaatctgaa 600

ggtccattgc aacgaatccc gctccgctct gacccaagaa ctccgcactt tctctccacc 660

agcctttcaa atacctgaac ttcatgcctt caagaggtgg attccggctt ctttacagcg 720

caatcactag caggtcattt ccgtctagct tgcagatttc ccattactga cacaaacgct 780

ccctcagggc gtccccgtct ggactacagg agaaagtttg ggaggcaggt tcaacttttc 840

aacttggcgg ggaattcctc tccctcttac acagtttgca gcgcgggggc ggcggggtga 900

cagtccccgt gcatgaatca gccacccctc aggctccgcc ccggcggggg tcggccggac 960

gctcgccccg cataaagcgg gcacccgggc cgcctggagc agaaagccgc gcacctcctc 1020

ccgccaggcg ctttctcgga cgccttgccc agcgggccgc ccgaccccct gcaccatgga 1080

ccccgctcgc cccctggggc tgtcgattct gctgcttttc ctgacggagg ctgcactggg 1140

cgatgctgct caggagccaa caggtatctg gccgctccag gagcttctct ccccaaccgg 1200

<210>115

<211>1200

<212>DNA

<213>智人

<400>115

cccaaattgt tctatagatt caaaacattg ccagttaaaa tctcagtgga ctttgttttt 60

ttgaaactga caagctgatt ctgccattta taataatatt caaaggggca agaataacca 120

agacacattt gaagaagaac aaggaggaag aagaacgtat ttgaagaaga ataaggaact 180

ctattaagtg tatatctcct atatattgag atacacattt gaaatacatc tatcacctag 240

atattgagat atattataca tttaatatag tgtgttgctg gtatagggat agacaaatga 300

acattggatc agaatagcac tgaaacaaga tctaccccta tatgggcatg tccctattaa 360

caaaaaaata ttgttgatta tttcctcaag atgatctgta aaaaacaagt taattgaaca 420

tccatatggg aaaaaagtga atccttctgc tacctcaaat atcaacccca ggtagattat 480

agatctaaaa gtgaaaggca aagcaataaa gattttagaa aataacaaag agaatatctt 540

tatgaaaata caggaaatat tttaaaaata ggctagaaaa ctcactatta aaatatataa 600

aatataagaa catctgttca tcaaaagtac tatagtttga atagcagtgt ctcctccaaa 660

attcatattg aaacttaatc cccattgtaa cagtactaat cctaaaacta agtattaaga 720

ggtgtgacct gtgggaagtg actaagtcat gaggggtctt tcctcaggta tgggattagc 780

atccttataa aaggccttga gatggaatgt agtgccccct tgccctcttg cgttctccca 840

tgtgaggaca cagcaacaag gcaccatctt ggaaggagag agaagccctc accagacaac 900

agtgcacatg ccttgatctt agacttccca gcctccagag ctataataaa tacatttctg 960

ttctttataa attacttggt ctctggtatt ttgttacaga agcactaatg gactaagaca 1020

aaaagattcc attatgaaag tgaaaaggca accgcagagt ggcagaagct tttggagatg 1080

atgaatatgt ttacttcctg gattgcggtg atgataccat gagtgtatac atatgtgtgt 1140

atacataatg tatacaaatt gtgttcattg attatgtaca gtttctttgt ataccaatta 1200

<210>116

<211>1200

<212>DNA

<213>智人

<400>116

gggaaagtct ggaagaacac actcttctgg atctaatcta agttttctca ctacccacct 60

atcatgagta cctttttcag tctctctagg ccaagggttt cttatttaaa aggaccaaga 120

gactccttga tccctaagat tcctgctaag attctgtacc tctttcctcc caaaagaatg 180

actggtcttg aattctaaaa tgcaattttt gtgagtgtgt tttaaaaaga agactgcatt 240

tcgctgaaaa atcttccttg gaaagtatat aaatcttatt agacgccttt gagagtcatt 300

aaaagaactg aagcatcatg cacgtttaaa acattaccag gctggatgga gtacgaaggc 360

actcagggga aggtacttaa acctccgtag gttcaaccaa gtcttaccgg gagtaaccca 420

acgaacaagt gatgcttttt gagacaaatt tggagagttg gctgcaggaa aattaacaag 480

ccagtggatt tccttttccc ttccttagga aacttgtttc tgtagatgca aaaagggccc 540

tagatcctct ggaagagaaa gagagtgggg aggggaagtt tctctttctt tactccccac 600

ctgcggtctg tctgatttcc tctccagctc tgtctgataa ggaattgatt ctccccctcc 660

tcttccccct cccgccctcc ctctccttct ccctgagtaa cgatgctgtc ctagcaagtg 720

atgctgtcgg agacaggaga cgggcgccga ggaggcatcg ccgccgccgc ggggctggag 780

agcctctccc agcaccagag ccccgctcgg ccccgggctt cctcgtcgca gccacggccg 840

cggcagctgc tcccacggtt tgatggtggg cggcggcagc tcggcttcgg cgctagcctc 900

taactgctgg atcgcgggcc gcgacgctct ccgctcctgc cttcccgccc tgggccgccc 960

ggggccccgg aagccgcggg aggtggtgaa ggggcgccgc gggaagactg cactgccgcg 1020

aaggcggagg aggccggcag ccggcacccc cacactcgga ccgcagccgg cgcgatgtcc 1080

accaaggtca ggaagtgcaa agaacaagca agggtgacct tcccggcgcc ggaggaggag 1140

gaagacgagg gcgaggacga gggcgcggag ccgcagcgcc gccgccgggg ctggaggggc 1200

<210>117

<211>1200

<212>DNA

<213>智人

<400>117

tctccaactc ctaggctcaa ctgatcctcc cgtctccgcc tctcaaagtg ctaggattac 60

aggtgtgagg cactgtgccc aggtgagagg taagatttct taaacagagc agaaaaacac 120

taaggtaaag gggaaaatga caaattggca catattaaga tgaaaaactt ttgttcttca 180

aaaggtacca ttaagatggt gaaaaagtag gccaggtacg gttgctcatg cctgtaatcc 240

cagcactttg ggaggccaag atgggcggat cacctgaggc caggagttca gaccagcctg 300

gccaacatgg caaaaccatg tcttgactaa aaatacaaaa caaaacaaaa caaaacaaac 360

aaacaaaaaa accgggcatg gtggtgggcg cctgtaatcc cggctacttg ggaggctgaa 420

gcaggagaat cgcttgaact tgggaggcgg cagcttcagt gagctgagat catgccattg 480

tactccagcc tcggcgacag cgaaactacg agtccaaaag aaaagtaacc ccacagagtg 540

ggaggaaata tttgtaatac ctatactgga agagaaatat ttgtaatacc tatactggaa 600

gaatgactga ctagtatcta gcatgtacaa aggcttccta caaatccata tgaaaaataa 660

cgtcagccca gtagagaaat agggagaagc ctcggatact gcacaagaga gaatatccta 720

gtggccaaca aacacatgag aaggttctca gctcattaga ctttggctaa atgcaaatta 780

aaaccaccat gtaatatcat tactcatcca gcacgatggc taaaataaca aagacgtaaa 840

gacaccacca cagactcgcg agactgagga gtgagtgtcg cgagactgag gggtgggtgt 900

cgcgagactg aagagtgggc ggcgcaaatg ggcgaggtgt ttactcgcca ttttgtgtga 960

ggaacgttga cgctacctac ctctggcctg gcctctaccc actgctgccc tggccgctac 1020

caacatgagc ctcccggaga gtcctcacag ccccgctact ctcgactatg ctctggaaga 1080

cccgcaccag ggccagaggt cccgagaaaa gagcaaggcg acagaggtaa tggcagatat 1140

gtttgatggc cgcttggagc caatcgtgtt cccaccgccc cggcttccag aggagggggt 1200

<210>118

<211>1200

<212>DNA

<213>智人

<400>118

atctgttaac ctcaacttcc taaatagaag gtctattctt ttaccatcat cattattctc 60

ttcggtgcct atttttaaaa aatactcaac cttcttgctt ccttcgctac ctaagtattt 120

ctgcaagccc actttgttct gcagcttagc tttcctggca caattcttat agattttggt 180

cccttttaaa attcattctt cagcaaatgc tttctctctc catcttttga ctagagatca 240

ttagagatca cctgagatca ttagagaaca gtggtttcct tggttgccat tccctttctt 300

cttcattggg agtattctgc ggtgaactca gacattttat ttttcaaagc ttcccattct 360

tttaaaaatg cttttccttt tacagcctct cgctcaaaat catacccatc ttttccctgg 420

atctgttttc tcaagtctcc aatcgcctgc cttctttgtg tcttgtatta ccctcacatc 480

ccccagcttt ctactgctct cccaggacca accatttctt ccgcgggagt cacattacat 540

cagcattcct aatgcagtat ctgttatcta ccagattctg ttttattcta ggtagtcact 600

taaaaacgaa cctcggtact ggtctgactt aacatggagg aggaattgtc taaggttaaa 660

cgcaaactgc tgagagattt ggggcggggg gcacacattt acattcattc gtattaaata 720

tatacctgtt gaatttgtgc tttttctcaa atgcttcaga gactcgagct ttagagtaat 780

tgggatggtg aaaggatggg tttccagaaa cttcgcccaa aattaaagac tccatcaaaa 840

ggactgctcc atacactcaa ggaacaccca ccaacaaatc ccgtctccac aaccaccaga 900

ttatctcacc ggcgagtgag actgcaaggt ttgggggccc ggccgtacca ctccgcgctg 960

cgcacggggg gttcgtaccc atctggccgc gaccgtccgt ttccccctcg cttggttctg 1020

cccctgctcc ccctgcacag gcctcacagt gcgtctggcc ggcgctttat agctgcagcc 1080

tgggcggctc cgctagctgt ttttcgtctt ccctaggcta tttctgccgg gcgctccgcg 1140

aagatgcagc tcaagccgat ggagatcaac cccgaggtga gcgccaggtg caccgctacc 1200

<210>119

<211>1200

<212>DNA

<213>智人

<400>119

aaaatactca accttcttgc ttccttcgct acctaagtat ttctgcaagc ccactttgtt 60

ctgcagctta gctttcctgg cacaattctt atagattttg gtccctttta aaattcattc 120

ttcagcaaat gctttctctc tccatctttt gactagagat cattagagat cacctgagat 180

cattagagaa cagtggtttc cttggttgcc attccctttc ttcttcattg ggagtattct 240

gcggtgaact cagacatttt atttttcaaa gcttcccatt cttttaaaaa tgcttttcct 300

tttacagcct ctcgctcaaa atcataccca tcttttccct ggatctgttt tctcaagtct 360

ccaatcgcct gccttctttg tgtcttgtat taccctcaca tcccccagct ttctactgct 420

ctcccaggac caaccatttc ttccgcggga gtcacattac atcagcattc ctaatgcagt 480

atctgttatc taccagattc tgttttattc taggtagtca cttaaaaacg aacctcggta 540

ctggtctgac ttaacatgga ggaggaattg tctaaggtta aacgcaaact gctgagagat 600

ttggggcggg gggcacacat ttacattcat tcgtattaaa tatatacctg ttgaatttgt 660

gctttttctc aaatgcttca gagactcgag ctttagagta attgggatgg tgaaaggatg 720

ggtttccaga aacttcgccc aaaattaaag actccatcaa aaggactgct ccatacactc 780

aaggaacacc caccaacaaa tcccgtctcc acaaccacca gattatctca ccggcgagtg 840

agactgcaag gtttgggggc ccggccgtac cactccgcgc tgcgcacggg gggttcgtac 900

ccatctggcc gcgaccgtcc gtttccccct cgcttggttc tgcccctgct ccccctgcac 960

aggcctcaca gtgcgtctgg ccggcgcttt atagctgcag cctgggcggc tccgctagct 1020

gtttttcgtc ttccctaggc tatttctgcc gggcgctccg cgaagatgca gctcaagccg 1080

atggagatca accccgaggt gagcgccagg tgcaccgcta cccggagagc gcgaggccga 1140

gggaggggga gccgagtcgc tgatcggttc ggttttgcct ttttctttgc atttgccttt 1200

<210>120

<211>1200

<212>DNA

<213>智人

<400>120

aaatactcaa ccttcttgct tccttcgcta cctaagtatt tctgcaagcc cactttgttc 60

tgcagcttag ctttcctggc acaattctta tagattttgg tcccttttaa aattcattct 120

tcagcaaatg ctttctctct ccatcttttg actagagatc attagagatc acctgagatc 180

attagagaac agtggtttcc ttggttgcca ttccctttct tcttcattgg gagtattctg 240

cggtgaactc agacatttta tttttcaaag cttcccattc ttttaaaaat gcttttcctt 300

ttacagcctc tcgctcaaaa tcatacccat cttttccctg gatctgtttt ctcaagtctc 360

caatcgcctg ccttctttgt gtcttgtatt accctcacat cccccagctt tctactgctc 420

tcccaggacc aaccatttct tccgcgggag tcacattaca tcagcattcc taatgcagta 480

tctgttatct accagattct gttttattct aggtagtcac ttaaaaacga acctcggtac 540

tggtctgact taacatggag gaggaattgt ctaaggttaa acgcaaactg ctgagagatt 600

tggggcgggg ggcacacatt tacattcatt cgtattaaat atatacctgt tgaatttgtg 660

ctttttctca aatgcttcag agactcgagc tttagagtaa ttgggatggt gaaaggatgg 720

gtttccagaa acttcgccca aaattaaaga ctccatcaaa aggactgctc catacactca 780

aggaacaccc accaacaaat cccgtctcca caaccaccag attatctcac cggcgagtga 840

gactgcaagg tttgggggcc cggccgtacc actccgcgct gcgcacgggg ggttcgtacc 900

catctggccg cgaccgtccg tttccccctc gcttggttct gcccctgctc cccctgcaca 960

ggcctcacag tgcgtctggc cggcgcttta tagctgcagc ctgggcggct ccgctagctg 1020

tttttcgtct tccctaggct atttctgccg ggcgctccgc gaagatgcag ctcaagccga 1080

tggagatcaa ccccgaggtg agcgccaggt gcaccgctac ccggagagcg cgaggccgag 1140

ggagggggag ccgagtcgct gatcggttcg gttttgcctt tttctttgca tttgcctttc 1200

<210>121

<211>1200

<212>DNA

<213>智人

<400>121

tgcttccttc gctacctaag tatttctgca agcccacttt gttctgcagc ttagctttcc 60

tggcacaatt cttatagatt ttggtccctt ttaaaattca ttcttcagca aatgctttct 120

ctctccatct tttgactaga gatcattaga gatcacctga gatcattaga gaacagtggt 180

ttccttggtt gccattccct ttcttcttca ttgggagtat tctgcggtga actcagacat 240

tttatttttc aaagcttccc attcttttaa aaatgctttt ccttttacag cctctcgctc 300

aaaatcatac ccatcttttc cctggatctg ttttctcaag tctccaatcg cctgccttct 360

ttgtgtcttg tattaccctc acatccccca gctttctact gctctcccag gaccaaccat 420

ttcttccgcg ggagtcacat tacatcagca ttcctaatgc agtatctgtt atctaccaga 480

ttctgtttta ttctaggtag tcacttaaaa acgaacctcg gtactggtct gacttaacat 540

ggaggaggaa ttgtctaagg ttaaacgcaa actgctgaga gatttggggc ggggggcaca 600

catttacatt cattcgtatt aaatatatac ctgttgaatt tgtgcttttt ctcaaatgct 660

tcagagactc gagctttaga gtaattggga tggtgaaagg atgggtttcc agaaacttcg 720

cccaaaatta aagactccat caaaaggact gctccataca ctcaaggaac acccaccaac 780

aaatcccgtc tccacaacca ccagattatc tcaccggcga gtgagactgc aaggtttggg 840

ggcccggccg taccactccg cgctgcgcac ggggggttcg tacccatctg gccgcgaccg 900

tccgtttccc cctcgcttgg ttctgcccct gctccccctg cacaggcctc acagtgcgtc 960

tggccggcgc tttatagctg cagcctgggc ggctccgcta gctgtttttc gtcttcccta 1020

ggctatttct gccgggcgct ccgcgaagat gcagctcaag ccgatggaga tcaaccccga 1080

ggtgagcgcc aggtgcaccg ctacccggag agcgcgaggc cgagggaggg ggagccgagt 1140

cgctgatcgg ttcggttttg cctttttctt tgcatttgcc tttcagatgc tgaacaaagt 1200

<210>122

<211>1200

<212>DNA

<213>智人

<400>122

ccccagtcta gaaagaacct ggcgtgtagc aggatgcaac atatacttgt agaatgaata 60

aaaaggtaat aaaataacac gagctcacat agcggccagc atttgctgtg caccataatc 120

cgtgctaagc actttgcatg cgttatttaa tttgaatttc ataacagtat tacataagaa 180

aacaataggg ccaggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 240

caggcggatc acgaagtcgg gagctccaga ccagcctgac caacatggtg aaaccccatt 300

tctactaaaa ctagaaaaag tagccaggcg tggtggcgtg cgcctgtaat cccagctact 360

tgggaggctg aggcaggaga attgcttgaa cccgggaggt ggaggttgca atgagctaag 420

attgcaccac tgcactccag cctgggcgac agagtgagac tccgtctcca aaaaaaaaga 480

agaaaaagaa aagacagtat tttgctccct caccgccttc aggcttttaa ccaactgcca 540

cttaccaccc tagtgaaggt ttgcccgagt gccctattta atattgcagg cttctgtttc 600

ctaccagccc ctttgcttac tctttcacac ttagtcacct tctaacgtgg catacattgc 660

ttattttcta tgctcatgag tatgtctact ccatggaggc atagatgttt gtatgcctgt 720

ttactgatgg atcacaaact gtgtagccta aaatagagct agcacatagt cccacccaac 780

acgtgtcagg tgagcaatta gatatagagg gttccaataa cttgtgggga cacccagata 840

agatctgttt atgactcatg tcttacacag agctcattct tggtctcttg gttagtttat 900

cagagaagac aaatgtatta ttggaaaatg tgtcttaggt cattttttga cagtggctct 960

aatactggaa tctattttaa ctaaaggtta ttatcataaa gcaggtgttt gctgaagaca 1020

gcttactcag atcactactg cctggaggtg gttgatatat cctggtgtaa accttcaaga 1080

agggcacagg caggaaaaca tgagccagca actgaagaaa cgggcaaaga caagacacca 1140

gaaaggcctg ggtggaagag cccccagtgg ggctaagccc aggcaaggca agtcaagcca 1200

<210>123

<211>1200

<212>DNA

<213>智人

<400>123

cctagctccc ctttctgtca gttttttaat tttatatttg ttttcaaatg agtcctcaca 60

ttgattttaa aaatttaaca agagtatagt gaaaaggaag ttcccctttc actatttatc 120

ttccccatat gcatctatta tgacgggttt cttttttaaa ctacttggag tactcataac 180

tgattttgta ctctagttca gaagaaatgt ctgaatgtta aatgtttaca taaaaaatgc 240

tattttatta tatcagtaat ggagcttccc ccctttaaaa ctgctgcacc aggaagatac 300

aaccttgtta tcacaattta aagagaaaat gagacttgga ggttcagatt cctccacagt 360

catagtatca gctacccacg cagtgaccca cattcaggtg attacacaca ctcatacaca 420

gatccataca cgatcttgcc ccccccacct ccacacactc aatatgacct ccccacgccc 480

aaagctgcac acatcttgac ctcacttctc tcacacacac accaatctga cccgcacgcg 540

gtttctttca ctcaactacc cagacacccc tcatcccacc agcacaagca ggcccaccgc 600

ggtctcacac acactcgagc cttcctttgc ccagtctcac atgcatgact gggatcgcgg 660

atttgtcccc ttccgactcc ccatgctggt tcggtcccag acgctcaggt gccacattgg 720

ggtgcgctct cccggctcct ccacacgcta cgcagctgcc cgcctcaaga gcgtctgcgt 780

gcttccagcg ttaagtggaa ttccaagcag cctccggggc acagttagtc tggtcactgc 840

ggccagactg ccgcctcagg acccagagaa cgcagcacac tttagttggg cccatctatc 900

cccggcgagg cttggactac gtttcccagg agaccctgcg gtccagtatg tctcccgagg 960

aggggcggaa gcccgggagc cgccctctga ggctgggcgg ggtgaaagaa agcttgcccc 1020

agaggactta aacaggcaag aaggacttgg ttaaagacta ttgcaatagt caacttccaa 1080

tacaacagca gctggagatt tatagctaac gggctgggtg aaggagttaa aggatgctaa 1140

attactaaga ggaagttaag tatcaagagt ggggggattg ttactaaact ggcttagctg 1200

<210>124

<211>1200

<212>DNA

<213>智人

<400>124

acattgcctc ctgtcttgtc ttccctttcc tcttatgtta aaaccagatt ctgttcctct 60

gctgtagccc ttactgagct ccatcttctc tcaatgttat catcatagaa tttggaggca 120

aacttatttc ttaaatggca taaacaaacc acattctaac cacagatgaa tcttccctct 180

ccatagctca ttccatactc atttagcaca ttagtctttc attgggaaac tgctctttgt 240

ggattatctt tcttttctgt ctccatcagt ttatatgcaa attatgttta ttactgaaac 300

atcccagatt tcccacccca ggaaaaatgt agtactccca acaaccctga taaatgaata 360

tgagaattac tctcatttat aaatgtttat agcactagat tcatctctta aaaaattaag 420

acagggccag gacatctgta taattaccaa gctttcaaag tctgcaggac ttttaaacta 480

aactaaacta ctatttaaaa ctactatttt aaataaatat ctaaactact atttaaaaat 540

aatctgtttc ctgaaaacct cctccacttt ctagtctgac ttttactcat tttctctgct 600

tccctaatct gtttttcaaa ttgcccagtc atatgtgaga actgtataaa ccactcaatt 660

tttatgaaaa ttaaattgta gttaagtctt tcgtatctat tataaacgtt taatctctcc 720

cagaacacaa aaaagtgaat gtttgctttt atattttctt tcagactatg aatcaaagtt 780

gagaccaaga aattatttct gaaaaaggat atggaaaacc ttacaaaaca cagcattgag 840

tgttcaagtt tcagaggtga ttgggaatgt aaaaaccagt ttgagagaaa acagggatct 900

caggaaggac atttcagtga aatgatattt actcctgaag acatgcccac tttcagtatc 960

cagcatcaga gaattcatac tgatgagaaa ctccttgaat gtaaggaatg tgggaaggat 1020

tttagttttg tatcagtcct tgttcgacat cagcgaattc atactggtga gaaaccttat 1080

gaatgcaaag aatgtggcaa ggcctttggt agtggtgcaa accttgctta ccatcaaaga 1140

attcatactg gtgagaagcc ttttgaatgt aaagaatgtg ggaaggcctt tggtagtggc 1200

<210>125

<211>1200

<212>DNA

<213>智人

<400>125

ggccgttatg aagaggaaga agtactgtgt catctattgt cctggggacc tgtcaacagg 60

aacaatagat agacatcacc aggggtgtat ttctgttcaa cacaaggaaa agtttctaat 120

tggagctgtc cagcatgaaa tggactaagc agtgcatttt ctttctccga tcctgactcc 180

actgtgacgg gcactgcaga ctagagagat tgtgtcctag tatgaattta ggttggataa 240

atgatactta gggataaaga gaggaaagga atatcagaat ctccaagaag ctgatacatt 300

ttgaaaaaat atataaaatg ccacacttca ggttttcttg tgtttaattt gaaacgtcca 360

gtaacattaa agaacagcat ttgatttgct taaacaaagt agtaacagct gaagttcctt 420

ccaaatcact tttctgattc tctaagaggc ttgcctatgc cttgcagatc tagcttcacc 480

tacaagacat attctgtaag gatccaggtt cagcaaggtg tcagaatgtc ctaagggttt 540

ctgtcccggc gctctgcctg tcccgcttgt gcacaatgct tttgcctatc cctgtttctg 600

catagatttt agtcttccca ccagggacgc aactgtcagt ttcctccgtc tctctcggtt 660

ctattccaat ctgctcatct cccctcccgt ccccgctttc cccaaggacc tactgagatt 720

tcgatcccac aacttagtgg gtcccatctc acccaggccc cgcaatcctc gccttctact 780

tgtcagcgtt gtactacact ctgagcaggc acccctgtgc tactcacgga agcgggacca 840

ttaggtcggc cattcctcct caccccacga cacgcaccca ctgggtcggg ccgcctcctt 900

gcagggagtc tcaaggatgg gctggcgtca gggaggggcc cagggggcgc tttcccaaca 960

ctggtcgcag tcattgttgg tataacggct agagacgccc agtgagttag catggagggc 1020

agtgggaccg gaaaaagacg tggaaaagct gcgaaaacga gccttcgaat catggacgcg 1080

cgggcccagc tcctcctccg agttcctcat ccggggccgt cactcacatc cggggccctc 1140

actcacatcc gggaccctca tccggggctc tcacccacat ccgggaccct catgcctggg 1200

<210>126

<211>1200

<212>DNA

<213>智人

<400>126

ucguutuutu tuuattttau agaggaggaa aucgagggtt gagcggcgaa tgatttguuu 60

tguutguuua guacggaaaa aaatuautut tutgguuuua gtcguutuuu tttutgtgut 120

gtgagtutgt gtuuagagua ggaagggutg utucgagutg uagggacggg ututgtgtgt 180

taaauuttua aatgguttuu agggautuat ggaguatuua ggauauutgg agatggcgau 240

tuutgggauu uutgguuutt uuutuututg guuttcggtu cgtgagggtg aattaagtgt 300

guuauuuauu agggguagag auauatggag auagagattg agagauagag aauagagggg 360

gagauagaaa gagagaggga uatgaagagu aacggagtta uaggaggatu tgacgutucg 420

ttggggagau agggagaaat gtggggagat guagcgtuuu aggtgutuuu uagtgguuut 480

guuuutuutu uuututuuuu tuuuuauuag guaggauuut uagggagutu uaguutggau 540

ucgaauuutg tuuuauuutg acguauutgu auuagguuag gutggauutg tggggtgggt 600

guagguutgg uuuuaguucg guuautguuu tggaaauuuu tuuuucguua agatgutgat 660

gtaauatuua ggatttgatg ttttaututu uaattutgua aatuuagacg uaggaggttt 720

taagaggucg ttguauuutg uaataaagtg cgggauauag gaatuttggt uutcggggua 780

uuuuuttuuu tcgggggggt ttcguuuuuc guautuacgg uuuutgaguu cgcgcggagg 840

uucgacguuu cgcggucgac gucggtuuuc guuucggguc guuattggut gttguuatgg 900

uauuaguucg tuttuucgcg uuutuattgg utgtutuauu cguatuuutu atuucguatu 960

utuuuucgut cgcggtggtu tcguuuagcg utaggagcgg uagcgucguu tguuuagguu 1020

cggaucgggu tttgtucguu ucggaguuuu tguucgcguc gcggagauuu cggaguucgc 1080

gcgutucgag guuauuucgg gucgggattt ucggtggggu ucgcggaguc gcguagaggg 1140

aggagguuuu agauuuaggc guuucguuag uuuagutgua cgtaagcggg tgtgtgtuut 1200

<210>127

<211>1200

<212>DNA

<213>智人

<400>127

aaaautgtua tggttauagu uatuaaatta uaggaggttu auauauagua gtuaguaatg 60

gtttgggaat attaaataaa tgtgtttutu taauaggaua agauaggatu atttatttat 120

guaauttaaa agutgtuuua gaaggagaaa aaagtagcgt attatttgtu uaaaataaau 180

aagattgaag aautgaauat utututgtgg atuaatttau agatuauatg gaaataggut 240

tatuttattg agaaatattu uattttagat gttuaaatau uttaguatat tttaaaaaut 300

atttuutatg tgauuaaaag aattuatgtt utattcggta aaaattaauu aaaattaacg 360

gtgutttuua atggacguag gaaauutttt ttutttauaa aatatguuua uuuttttttt 420

gttgutautt uuuauattga attuttgttt tautgaattt tuttautata aaaataaagu 480

atgatgatag ttttgaaaau aaaauagaag tatttgagaa gtauagauuu uautuuuaut 540

uuttgtutuu tttutgauau tutguuuutt aautatautg gaauagggag tuaautguaa 600

ggaaaatuut ggggautagg ggutgaggaa utagaggtgg agagatggaa gagtgtuuag 660

taguuuagga aaggatgaaa uaattuuuua auaaaaaagt aaaaattttu agtaguuutu 720

cgagaagatg uaguuuutuu uaggtaauua gagaaaggua aattgtgaaa guagggagaa 780

ggggutautt tagguutuua ggautauaaa gauaaaaaaa tgagtgauag gauutgatgt 840

ggtggggtga gatgggaatg gaagtaaagg agggggutcg taututtggt gggagtggaa 900

attggggauu uaaguttaut ggcgatguag uuutuacgtg auuaggagut gacgtgggua 960

aaggtautta aaguuutgau cgtcgttutu cgtuutuutu tgggtauuaa ututattgcg 1020

uagutcgutg ucgtgcgttt aauuuaggcg aggaggagga ggagaaaatt uuuuuagatt 1080

cggguaggtg ggtgtgaggg tggguauagt utgggauuuu tgaatagggt aatutaggga 1140

tgcgggagtc ggaggucgcg ggtguutcgg tutuuuuuau tuutggucgg utttuuagau 1200

<210>128

<211>1200

<212>DNA

<213>智人

<400>128

uuagauutga ggtgutuaaa cgcggutuat tttggtgggc ggtggggaaa gggggagggg 60

gaaacgaaaa gauttttgat agautttacg aagaatucgu ttauttuutt tuuaguuagt 120

gttttttggt tttgtttata atattuaggu ucguauuuua uattucgtuu tgttttgaga 180

ggaggaggga agagaaataa acgtgguagc guatagaagg uuaguaggga ggttgggaaa 240

gggtaauuag gaggcggggg tgggguatgu aatttggtaa uaatutgggc gguauautuu 300

uauuutgaut ttuuuuauua ucguuucggu auuutuuuat uuuuuagucg auuututgtg 360

atttgggagt gutgggaaat gggtgtauua gutgutgttg gagaggtggc gggtttggcg 420

utgtutgggu ttuacgggag gtggggggga aggggcggau uutgagagaa tutggtatta 480

aaucguuttg ttaautcgua gautgutttu uagauauutu cgguuuauau agucgttuau 540

uuuucgtutt ttuagtuutg gaaaaggaat tcgggtatgu aggcgggaga aatggcggtt 600

gttgggggga tttgtgggaa gtgggaggta gaguuuatag uagagaaatc gtggaaaatu 660

tcgauuutga auucgaaaag guagacgttg agguuuutut tutguaggut aacgutaggu 720

utaggggutg gggagcgaaa gatgggtgat uutgggaggg gaauautgaa ttgtttggua 780

ggagtuuuuu ataucgcgtu uuatuuagut tttgutguau uutcguuucg utuuuutuuc 840

guttcgttgu aggagaaggg gtgtggcggt gtgtuutgga gaaatggcgg acgggggcgg 900

gguaaagcgg aaggagggat tgagtguutg gggaguutgc guaggaggag gattgaggtg 960

ggaggggtgg ggtgagaaga gttgaaggaa ttgagaggta gaatuatttg auattutgat 1020

gtguaaauac gaaaagguag ttautgagau uuttgtuutg gatgutgatu uatuuauuag 1080

gutttuattg tutaacgtcg auagtutata tttutgutut tuagtutgtu uttaggatga 1140

agututaaut gaautgaagt aaggagaaau aguuttgaat utttggaggg tuagtgutgg 1200

<210>129

<211>1200

<212>DNA

<213>智人

<400>129

uuuagagttg aatuattaau tggaauutaa tucgaagaua ggtgtttaaa autgtuatgg 60

ttauaguuat uaaattauag gaggttuaua uauaguagtu aguaatggtt tgggaatatt 120

aaataaatgt gtttututaa uaggauaaga uaggatuatt tatttatgua auttaaaagu 180

tgtuuuagaa ggagaaaaaa gtagcgtatt atttgtuuaa aataaauaag attgaagaau 240

tgaauatutu tutgtggatu aatttauaga tuauatggaa atagguttat uttattgaga 300

aatattuuat tttagatgtt uaaatauutt aguatatttt aaaaautatt tuutatgtga 360

uuaaaagaat tuatgttuta ttcggtaaaa attaauuaaa attaacggtg utttuuaatg 420

gacguaggaa auuttttttu tttauaaaat atguuuauuu tttttttgtt gutauttuuu 480

auattgaatt uttgttttau tgaattttut tautataaaa ataaaguatg atgatagttt 540

tgaaaauaaa auagaagtat ttgagaagta uagauuuuau tuuuautuut tgtutuuttt 600

utgauautut guuuuttaau tatautggaa uagggagtua autguaagga aaatuutggg 660

gautaggggu tgaggaauta gaggtggaga gatggaagag tgtuuagtag uuuaggaaag 720

gatgaaauaa ttuuuuaaua aaaaagtaaa aattttuagt aguuutucga gaagatguag 780

uuuutuuuag gtaauuagag aaagguaaat tgtgaaagua gggagaaggg gutautttag 840

guutuuagga utauaaagau aaaaaaatga gtgauaggau utgatgtggt ggggtgagat 900

gggaatggaa gtaaaggagg gggutcgtau tuttggtggg agtggaaatt ggggauuuaa 960

guttautggc gatguaguuu tuacgtgauu aggagutgac gtggguaaag gtauttaaag 1020

uuutgaucgt cgttutucgt uutuututgg gtauuaautu tattgcguag utcgutgucg 1080

tgcgtttaau uuaggcgagg aggaggagga gaaaattuuu uuagattcgg guaggtgggt 1140

gtgagggtgg guauagtutg ggauuuutga atagggtaat utagggatgc gggagtcgga 1200

<210>130

<211>1200

<212>DNA

<213>智人

<400>130

tgtttaaaau tgtuatggtt auaguuatua aattauagga ggttuauaua uaguagtuag 60

uaatggtttg ggaatattaa ataaatgtgt ttututaaua ggauaagaua ggatuattta 120

tttatguaau ttaaaagutg tuuuagaagg agaaaaaagt agcgtattat ttgtuuaaaa 180

taaauaagat tgaagaautg aauatututu tgtggatuaa tttauagatu auatggaaat 240

agguttatut tattgagaaa tattuuattt tagatgttua aatauuttag uatattttaa 300

aaautatttu utatgtgauu aaaagaattu atgttutatt cggtaaaaat taauuaaaat 360

taacggtgut ttuuaatgga cguaggaaau uttttttutt tauaaaatat guuuauuutt 420

tttttgttgu tauttuuuau attgaattut tgttttautg aattttutta utataaaaat 480

aaaguatgat gatagttttg aaaauaaaau agaagtattt gagaagtaua gauuuuautu 540

uuautuuttg tutuutttut gauaututgu uuuttaauta tautggaaua gggagtuaau 600

tguaaggaaa atuutgggga utaggggutg aggaautaga ggtggagaga tggaagagtg 660

tuuagtaguu uaggaaagga tgaaauaatt uuuuaauaaa aaagtaaaaa ttttuagtag 720

uuutucgaga agatguaguu uutuuuaggt aauuagagaa agguaaattg tgaaaguagg 780

gagaaggggu tautttaggu utuuaggaut auaaagauaa aaaaatgagt gauaggauut 840

gatgtggtgg ggtgagatgg gaatggaagt aaaggagggg gutcgtautu ttggtgggag 900

tggaaattgg ggauuuaagu ttautggcga tguaguuutu acgtgauuag gagutgacgt 960

ggguaaaggt auttaaaguu utgaucgtcg ttutucgtuu tuututgggt auuaaututa 1020

ttgcguagut cgutgucgtg cgtttaauuu aggcgaggag gaggaggaga aaattuuuuu 1080

agattcgggu aggtgggtgt gagggtgggu auagtutggg auuuutgaat agggtaatut 1140

agggatgcgg gagtcggagg ucgcgggtgu utcggtutuu uuuautuutg gucggutttu 1200

<210>131

<211>1200

<212>DNA

<213>智人

<400>131

ttauaggutt gaguuauuat guucgguuaa gatgtuagtt ttttaatggt gtguaacgtu 60

cgtttutttg atagttggaa agcgtgguag gtattagagg gcgaatgtat atttaagaaa 120

aauaagataa gtuttuatut gtagagtatt aatttttutg tgatuuttta tutuagacgu 180

ututuututg aaggtuautg utuaagutgg guaguuuutt utaagaaggg atgutguutt 240

ggagttggag atgaggttaa gatutacgtg cgggtauuag tttuagtaat aautggatuu 300

ttututaggt utaggutgga acgtutuaag tgaaggttat tgggggguag gggtttgggt 360

uuauuuaaaa agguttgauu uataggautg aaatuaaatu ttgagutagg utgguttguu 420

acgtaauuau agaaauagta atttaaguaa taaaatgaaa gutcgagcgu tggtuuagag 480

utggggttgg gauagutaut guautuaggt utuuaggtgu atgtagggag aagaguagcg 540

gatuuuttgu agauaatggt gggagcgagu tuttuauuut ggggtutucg aaguuuattt 600

ttagcgtuua gaggtgtgut ttcguuatut uuttutgcgg tggutguttg uagggcguat 660

tuuuattgut gutgtututg ttuutaagga agatuaaagg atuuuagaaa auuuagttuu 720

agagutuagt tuucgggaut agagggtacg utcgguuaga tggutggggg tgucgutggu 780

uttggcguuu ucgucgtuuu cgcgcggtcg uuuauuucgg uucgauaagu aguttgggcg 840

tuuaguucgg uucggtuuut guagggaggg agcguaggag utgggggcgg ututuucggg 900

gcggggutcg utuuauaagc guuagggguc gcgcggggcg tgggcgtggg cggggucggg 960

ggcggggucg guuttggutg ucgcgguaua ggcggcggcg tutuuagggg gaguuaaggt 1020

acgtaggcgg cgtucguutu auucgaguat uuttuuucgu cggtggucgu ucguucgcgg 1080

uucgcgutcg uaguutuucg uutggcggtt gauttutttg tgtcgtattu tutguutgcg 1140

uuutgtutut guaggauutg ttcgttuttu tttgggutat aagaagguag aggatgagat 1200

<210>132

<211>1200

<212>DNA

<213>智人

<400>132

ttutgtgatu utttatutua gacguututu ututgaaggt uautgutuaa gutggguagu 60

uuuttutaag aagggatgut guuttggagt tggagatgag gttaagatut acgtgcgggt 120

auuagtttua gtaataautg gatuuttutu taggtutagg utggaacgtu tuaagtgaag 180

gttattgggg gguaggggtt tgggtuuauu uaaaaaggut tgauuuatag gautgaaatu 240

aaatuttgag utaggutggu ttguuacgta auuauagaaa uagtaattta aguaataaaa 300

tgaaagutcg agcgutggtu uagagutggg gttgggauag utautguaut uaggtutuua 360

ggtguatgta gggagaagag uagcggatuu uttguagaua atggtgggag cgagututtu 420

auuutggggt utucgaaguu uatttttagc gtuuagaggt gtgutttcgu uatutuuttu 480

tgcggtggut guttguaggg cguattuuua ttgutgutgt ututgttuut aaggaagatu 540

aaaggatuuu agaaaauuua gttuuagagu tuagttuucg ggautagagg gtacgutcgg 600

uuagatggut gggggtgucg utgguuttgg cguuuucguc gtuuucgcgc ggtcguuuau 660

uucgguucga uaaguagutt gggcgtuuag uucgguucgg tuuutguagg gagggagcgu 720

aggagutggg ggcggututu ucggggcggg gutcgutuua uaagcguuag gggucgcgcg 780

gggcgtgggc gtgggcgggg ucgggggcgg ggucgguutt ggutgucgcg guauaggcgg 840

cggcgtutuu agggggaguu aaggtacgta ggcggcgtuc guutuauucg aguatuuttu 900

uucgucggtg gucguucguu cgcgguucgc gutcguaguu tuucguutgg cggttgautt 960

utttgtgtcg tattututgu utgcguuutg tututguagg auutgttcgt tuttutttgg 1020

gutataagaa gguagaggat gagatgtuuc ggguuacgtu tgttggagau uagutggagg 1080

uauucguucg uauuatttau utuaauuaau cguatutuaa uaaattucgc gauaauuaga 1140

tuaggtagga gaaggcgguc ggutcgcgcg gaaggcggtg gagtuauagu tgggaagggg 1200

<210>133

<211>1200

<212>DNA

<213>智人

<400>133

ttgtuagtuu utaatgttaa tttaggttaa aagaaatgta atgutcguat uagtaaaagu 60

aaggtuagau tttuauutga auagttttat ttttgttttg ttucgttttt autucgaggt 120

uagaatgtua tuagguauaa taaagatagu ttuttatutt uatgggattg tguuuagaaa 180

gauuaaguau agtutaaaua ttacgcgata agaaaaaaua aaaaatagat uaagtgauut 240

tggauaagtu atuttauutu tcgatggttt tgttttatga aagaaggtgt gtgtgtgtgt 300

gtgtcgatgg gtgtgtgtgt gtgtgtgtcg atgggtutgt gtgtgtgtgt gtgtgtgtcg 360

atgggtgtgt gtgtgtgtgt gtgtgcgtgc gggggttgag aaggttgutg ttaaggttuu 420

utagggutau utguaguttt aatatgcgta gttagaatgt uagguaggtt gtggagagtg 480

gggggutgga gauuuucgau ttututgagt guuaaguuau auatuagaua uuttggaaat 540

aauuuttuua cgaagtuuut auauagatuu uauuaggutg gguacggaag aauagaaaut 600

gcgaaaagaa agggautgga tgagtuutgg ggaatuauag cguutuuaut tguauaggau 660

aagtgauagg uaggtaaata ggtaguagau agguagagau tucgagtuuu uuaggtguau 720

uuututuutg gaagaguuuu cgaaagtaua gguuuaatut uuuauuuuau uaaguuutuu 780

uuatcguutt uuucgauauu taaaaguuuc ggtuutgcgt aatattgcgg atuuutuuua 840

guutuucgtu cgutuutuut uucgcggggu tucgutuagg gucggtuuuu cguuuuuacg 900

ucguaguucg gguuagcggg guucgucgcg gtggcgttcg cggatgutgu cguattgguc 960

gutgcgguac ggacggcgua guutcgggcg cgguucggua uaggcgucgg cggtuuucgu 1020

uagutaguag uucggcgagg cgutgguuua uuuatggtuu tcgggcggcg guuuutgcgu 1080

uuaguuutgc gcgtaguutu cgtututcgu ucggggucgu cgaguuuucg auacgggcga 1140

gatgutgaac ggcguagguu tggauaaagu tuttaagatg tuuutgucgc ggaggtcgag 1200

<210>134

<211>1200

<212>DNA

<213>智人

<400>134

guuaaagtga tatattaagg tuauuauutt ggtuauutgt uuatutatat ttttggagta 60

aguaauagaa ttaggagtut gaauatagga attaagaagu tutcgaatat aauagtggaa 120

gauuaguauu ttuuuaauut uttgtuaggg uagggataut utatututgc gtuautuaau 180

utguuttggu utuauagutu ttuuttttgu ttaagtuttu aaauuatuaa uagtgatagu 240

uautaatttt aguaggtggu attagttgtu aguaaatgtt ttttuatatt taatgaatgt 300

ttattataat agaataaaat agaaatgttt attaataaaa uttgaaattt gtuuuagaag 360

gataaaaacg tagattattt auataaaatg guuaagatut gauaauagaa utgtttuutg 420

aagatttaut tuauagatta ttttgaaaau auuaautgtg ttuaggaaaa ttttututuu 480

tttttttuat aaaattttua aauaagtgag aatgututaa aaatgatggt gtggaguuta 540

gagaaaatgt tttutgtgtg utatagatga auataaauta tatatatata ttautttuuu 600

aggttgaagt gtttutttua aaaataaaat ttgattattt tuaatttttt gagggatgut 660

gatttttaaa aaggaaataa agagaaatta ttaggaagua tatauauagu uagtgagaag 720

aggaaagaag aaaagguuaa gguuagagga agggggtttg gggtggggga aaggaagggt 780

auagauuutu uuaaataauc gaagatgggt aaautuuaau cguaaagcga tgatguuaut 840

tgtggguuut uagattggag aggacggaga tgagtgacgg ggutgtgcgu autgggguau 900

cgcguauaga cgggaggagg ggggtgtutg tgtgttuuaa aggggggagt auuagttaau 960

tggucgucgg uucgtggggg ttggtgagaa ggagggtgag uttggcggtg acguacgguu 1020

utuacgtgau cgggagutgu agagutacgu aguuttcggt guagtcgtua utcgtgtutc 1080

gutauuagut uuucgutguu utgcgutcgg cgggutggua tucgguucgg gggaaagcgg 1140

auuaggtaag gguuucgggg uucgcgcguu utggutaggu uaguagaggu tuaucgauuu 1200

<210>135

<211>1200

<212>DNA

<213>智人

<400>135

ttgauauttg gatttggatu aauaatgutt tuaagaagaa agauttttga tuaaaagcgg 60

gaaatgagaa agcgautttu ututgaaaag tguutuuuag tuucgaggut gcgagguuuu 120

uacguuaggu tggutuuuac ggaagucggg uauuuauucg guucgauuaa gcguuautuc 180

guuucgtgga cggggcgtuu uauuucgggg acguucguuu uauaucgcgt ttguauuucg 240

gagguuuutt gucguagagg cggacggcgc guututuucg gguuuutggg gtucgcguut 300

uuutcgggua gaututttcg aututgutcg aguutucgut tuttuutgcg ggcggacguu 360

ucggauauaa cggguuucgu tgttuacgua ggggcguuuc ggcggggcgg guaaagauuc 420

ggggacgcgg tuucgtuucg agacgutuag utucgguuua ucgutcguag utuucguuuc 480

gggcguaggt uucgauuuua cgggucgtut cggagucgua gcggucgutt uuutguacgt 540

uutuacguuu uucguacgga cgucguuagu uucgcguutu agtttuuuua utaguaggat 600

ggaaagacgg guuucguuuc gaagcgtagc ggcgtutucg tggtaguuag tguuuagaga 660

gtucgucggt uuuaucguuu uttuaaagga gaauucgguu uaucguucgu cgcggcggcg 720

aucgcguagu uuautcgtua cgcgguucgc ggcgtuuagu ucgggucggu tuauutuagg 780

cggtcgutgu cguuutcgcg uutgcgcguu uutcguuucg uuuututuuu cguucgcgtu 840

ucgcguaucg uagguututg uuuutcguuu aucguaggau ucguuucgcg uacgcgucgu 900

acgtguuaua cguauuuuac guuuutgcgu acgcguaggu uuuaagtcgc gguuaatggg 960

cgacgcgguc guagatucgu ucgguuucgu uutguuutgt gagttuutuc ggucgggutg 1020

cggggutucg utuagtucgg gagcguagut gggucgcggc gutucgauut ucgutttuuu 1080

aucguucgua gutgaaguau atuucguagu ucggcgcgga utucgatcgu cguagttguu 1140

ututggcguu atgtcguaga acggagcguu cgggatguag gaggagaguu tguagggtga 1200

<210>136

<211>1200

<212>DNA

<213>智人

<400>136

tgutttuaag aagaaagaut tttgatuaaa agcgggaaat gagaaagcga utttuututg 60

aaaagtguut uuuagtuucg aggutgcgag guuuuuacgu uaggutggut uuuacggaag 120

ucggguauuu auucgguucg auuaagcguu autucguuuc gtggacgggg cgtuuuauuu 180

cggggacguu cguuuuauau cgcgtttgua uuucggaggu uuuttgucgu agaggcggac 240

ggcgcguutu tuucggguuu utggggtucg cguutuuutc ggguagautu tttcgautut 300

gutcgaguut ucguttuttu utgcgggcgg acguuucgga uauaacgggu uucgutgttu 360

acguaggggc guuucggcgg ggcggguaaa gauucgggga cgcggtuucg tuucgagacg 420

utuagutucg guuuaucgut cguagutuuc guuucgggcg uaggtuucga uuuuacgggu 480

cgtutcggag ucguagcggu cguttuuutg uacgtuutua cguuuuucgu acggacgucg 540

uuaguuucgc guutuagttt uuuuautagu aggatggaaa gacggguuuc guuucgaagc 600

gtagcggcgt utucgtggta guuagtguuu agagagtucg ucggtuuuau cguuuuttua 660

aaggagaauu cgguuuaucg uucgucgcgg cggcgaucgc guaguuuaut cgtuacgcgg 720

uucgcggcgt uuaguucggg ucggutuauu tuaggcggtc gutgucguuu tcgcguutgc 780

gcguuuutcg uuucguuuut utuuucguuc gcgtuucgcg uaucguaggu ututguuuut 840

cguuuaucgu aggauucguu ucgcguacgc gucguacgtg uuauacguau uuuacguuuu 900

tgcguacgcg uagguuuuaa gtcgcgguua atgggcgacg cggucguaga tucguucggu 960

uucguuutgu uutgtgagtt uutucggucg ggutgcgggg utucgutuag tucgggagcg 1020

uagutggguc gcggcgutuc gauutucgut ttuuuaucgu ucguagutga aguauatuuc 1080

guaguucggc gcggautucg atcgucguag ttguuututg gcguuatgtc guagaacgga 1140

gcguucggga tguaggagga gaguutguag ggtgaggcgg aggaggcggc gcgggagucg 1200

<210>137

<211>1200

<212>DNA

<213>智人

<400>137

uuaauaattt gagcgguuaa gauagguagu tuauttgaag tuagaagttu aaguutgguu 60

aauatggtga aauuucgtut utautaaaaa tauaaaaatt agucgtggta gcgggcguut 120

gtaatuuuag utautcggga ggutgagaua aggagaatcg uttgaatucg gaaggcggag 180

gttguagtga gucgagatcg cguuautgua utuuaguucg ggcgauagtg cgagautucg 240

tutuaaaaat aaaaataatt agtaaattaa ttuattaatt taagaaaaaa agcguaatut 300

tuttuuaaag gcgatuuuaa ggutgttgga ggutgaaauc gutaagtcgu uuuutaucgc 360

gcgggtggut tcgtuucgga uuuutuuaga ggutgtguua utgutggagg tgutuagcgg 420

ggucgggauu cguttggggc gucgtucggg gcgaguaucg gaguucgaut gggutgaatg 480

guaggtuutg auuaaguuau ucgcgcgguu ucguucguut ggcgggatga gtgacggcgg 540

uaauaggtgu agagcggcgt ucgcgguttu tcgggaguuu ucgagttttg cgagtuaggu 600

uucgagagtu agagtttgau tutagaauut tuttcguttt auauuagtut tcggaagtcg 660

uucgtuaauc gguttuttut auutuagtaa aguuttaagg tuauutuaau ututcgaaau 720

uuauuagtuu uagaggucga ututtutuaa gtggaggaga ggggaaggcg tguatggagu 780

tttguutgau cgutcgutut utuutuuuua gucgtutgag agaaggcgag aggggtuuua 840

gaaucgaguu utcgutucgu acguuuuacg uucguuucgu tgtgucgtgc gututguuuu 900

tgagacguuu cggutcggag tuuuaggguu auagucgaaa utcguuutuu cgcguuuutu 960

tucgguttgu agcguucguu cguaucguua uutguuauuc gaggcgacgu agtucguttu 1020

tuuuuauucg uuaggtggua ggttuagggu cggggtucga guutguttuu utguagutgu 1080

uauaguuauu utcgucguua gggggcgaga gtuuuaggua ggauaaguag cgutgutguu 1140

ttggcgtgaa ggtggtttua aautttaggu ttuttttuuu tauuucgcgt ututgaagag 1200

<210>138

<211>1200

<212>DNA

<213>智人

<400>138

gaggaagatg gaaaucgagt ucgggucggt gagtacggcg atuaggguuu uagggcgcgg 60

gatagcgggg agaaggagua gcgtggaguu tgtuuutgag gguttggagg ggcgaggtga 120

agguuuuaaa cgutcgutat utggttggga agaaacgtgg uuaggtguuu uatcgaucgu 180

tguuaggagu uauucguucg uagauutcgt utggutgtgt uatgggggtu agaaaggcgu 240

cguuacgggg uutggautgg gtgtagacgg guuaggggau utuaggcgtg gatgtttcgg 300

gaggcggcgg gutguuaggu auuuagcgaa gtucgaguag gtaaaucgut ttuucgucga 360

aattggguta gguagcgtut ttgacgutuu utgcggucga autcgauuua gucguuuaag 420

gcgaggagtt guuagggcgg tcgacguutu uautuuucga utggtuagcg aggaucggaa 480

ggtutgagag auutgguagg guucguutgt gguuuaggcg ggauucggau aututaguuu 540

tggutgtgua uuuaaguuag tuagggtgga uttggggaag tgaaggagga utguucguau 600

agguucgagg cguagcggua acgtguuatu ucguuucguu ucgtuucguc guuaguaguu 660

aatuagggag cgucgcgcga gggtggggau uagutgcgua cgagguuagc ggcggggtcg 720

utgucgttga gguttuucgu uautgutgut ggcggatttg tgggguaaaa tttutcgutg 780

gutaguuttu ttttuuutuu cguautttgg tggggagggg gtggatuutc gtttcggtgu 840

uuaagttuac gatgauucga gagaautcga ggaagttgtc gucgcgguua tttuuuuuag 900

tgucguaaut tgutgguutt ggagggggag gagcgucgag guagtgautg cgacggttag 960

uucguucgtt uutgutgtut tcgtttguaa aatagatgut agatutcgag gttgattutu 1020

aaggggaggg guuagtgagg guauattgut ttggaggagt agtttaataa autututagt 1080

gutggaagtt ttaguaaacg gaggaguutt uaaauucggu aauagtuuuu atutaggtgt 1140

ttucgtaaua uatgcggaat tattgutagt ggaatttuag gutttutttg ttgtttaaut 1200

<210>139

<211>1200

<212>DNA

<213>智人

<400>139

ggattttgta tatgtuatua gutgttgtga uuttuuaauu uatgagaatt ttuutuatgu 60

utgaggattu auttaaggut auautttuag atuuagagat atutttuttt tuututtggu 120

tgggtuagtu tgautttggu tguatgatua uauattatta guaggtguta uuatttttag 180

gttagaatat gtgautttut taaagtaaaa aaaatuutat agtuututag uttatuaatt 240

uattaagtta aautttatat auuaattttu ttaaatggag gaatguuttt attaatatgu 300

aguatutatg tuattautaa attautatau uaauaaagat gaaataattt attguuuaag 360

ttggtutuuu uuuuauuuaa uutttttuuu uagttttgtg tggaagtttg atuaggagut 420

ttttuuatgg aggttttuag uttuuttagt tutagguaua aagttatgat utttuuutga 480

tgutgauuau uttaggatga tatutgatta ttagtuttgu tautgcguta ttaagtgtua 540

uttatttuta aggaaatgaa ttgagggtut tggauaggat aaggauagga atgttttatt 600

auuuauauta uagatgttgg aaaauaaagu tgaaaautut tttaatttgt gtutatautg 660

auatutgaat guttaauuua ttattguttt tttttttggt ggtggtgggt agagatgggg 720

tutuautgtt guuuaggutg gtuttgaaut uutgggutua agcgatuutu utguutuagu 780

uttuuaaagt uutgggatta uagguatgag uuautauatu uutattattg uuttutttaa 840

aaatuttttu ttututaaaa atutttttag atgttaatta auuuatutgg ttgttgtttt 900

tuagtagaga aatggtuaga aggaacgaua uuauagaaga aattagaatg tttaaaagaa 960

uuaggaaaaa uatutgtaga atutaaagta uutauuuaga tggaaaaatu tauagauaua 1020

gacgaggaua atgtaauuag aauagaatat agtgauaaaa uuauuuagtt tuuatuagtt 1080

tatgutgtgu uagguautga guaaacggaa guagttggtg gtutttuttu uaaauuaguu 1140

auuuutaaga utautauuuu auuutuatua uuauutuuaa uagutgtutu auuagagttt 1200

<210>140

<211>1200

<212>DNA

<213>智人

<400>140

taaggutgut tgtaututga taatuatgat tatggtgtta tttagaguuu aguuuaaata 60

uutgaguuta aatgagtgaa agaguagaga gtgggcgttt ttttgttttt tttgttttgt 120

tttttgtttt tttgagacgg agtutcgutu agtaguuuag gutggagtgu agtggtgtga 180

tutgggutua utguaauutu cguutuuuag gttuaaguaa ttututguut uaauutuuag 240

agtagutggg attauaggua uuuauuauua cgaucgguta atattttgta tttttagtag 300

agauagggtt tuauuatutt gguuaggutg gtuttgaaut uutgauutcg tgatuuauuc 360

guutcgguut ucgaaagtgu tgggattaua ggcgtgaguu aucgtguucg guagagtggg 420

cgtttttaaa tgaaguagta ttuutttagt ttggtaaaat tgagutgaag ttauauauag 480

taauauuttg auttgttgut gacggtgtgu tttgtgggga tagttggtgt utgatutuaa 540

utgtggagaa auaggaagtt tutggattua tgutgaautu uuattuuaua ggcgagtttu 600

auaaaagaaa aagtgututg ttguatauaa ttattuautg tgtgtutaua acgtgguaga 660

aattattatt uutaaaggtg aucgaagaga gutatagttt atgggguuag gaguaatgtg 720

tggaatggcg agguagtgau aagauaguau tguuataaat ututtauttt utttuuaaac 780

gagututaat tttaagutua acgauuaaag acggagaggu agtcgutttg agutautuut 840

ggutatttgt tgggaaatua uutaaatucg ttuagattta guuagaaaag gggaaataag 900

tutuuutcgu cgguuaaatu atgguutttg tcgutttcgg utuuuuattg gutgcggucg 960

utgtgguuuc guutuuttga gtggtgcgga gutttgtgat gcggaguttc gtgatguacg 1020

uuucgatguu tgcgggguta taaaaacgut cguaagcguu aagtutuutu aggagucguc 1080

gguaaggggg uaacgaggaa gututtaaga gcgcggucgg aaaguaggtg gggagaatut 1140

ggagaaaagg cguauuutgc gguutcggag auuattatgt utuagggagt ututcguagt 1200

<210>141

<211>1200

<212>DNA

<213>智人

<400>141

tggaaaatua gauauuagau uuutuauutg uaauaattgu utgatguutg ttgauuuaut 60

uututtuatu tutuuutaau tuutgutatt ttuuuauatg uagttauatt tuttuuutgu 120

tatatuutaa ttttaatuag ttgagaagat ggatttgaga utgatututu uuuuutaggu 180

tgtaguauuu aaataatguu ttuttuuutg auaataatgg ggtutuagtg autggutttu 240

tgtgutgtga auuauuagau utagauuaaa utuutgguat ttututaaua atttuuuauu 300

autgaautaa gttataaatt utgaggatgg atuuutgttt uttuatttta agatggggat 360

taaaaggtau atuutagagt gttattgtuc gtgtaaaata gggutgtgaa auuuuutaua 420

uutatguaua gataaautga tgguuutgua aatguuuaga gaagtaauut tataaagatt 480

tagtgaatgt ttuuuauuat tattggaaaa tutggutaag tuagtagutt tgttttuata 540

tauttagggg gaaaatuaau aaaaauttga tguuutgtta tttuuttuua gtttuttutg 600

uaaututagu tuuaaagaut guagttuutg uagtattttt ttttttagaa uauuaggaaa 660

aaaagaaaaa aaaauuatgu aaatgtauta tttuttuaaa uauaautagg aatgattgaa 720

uagutgggag aatatgaaga aaauuuutua gagaauuaag gguaaguagt gagttuagat 780

utagguauat gguuautagg aatggttutt uautguuacg tggguaguua auaguuagta 840

gutagagauu aguutcggtu ttcgguutgc gggttutgua aagtuaggut agutggutut 900

ucguutgutu cguauuucgg cgaggttucg gtggggaggg gtagggatgg ttuaguuucg 960

uuucgutagg gcgggguutg cguutgcgcg utuagcgguc gggcgtgtaa uuuacgggtg 1020

cgcguuuacg aucguuagau tcgaguagtu tutggaauac gutgcggggu tuucggguut 1080

gaguuaggtu tgttutuuac guaggtgttu cgcgcguuuc gttuaguuat gtcgtucggu 1140

atuuatgtag cgutggtgau tggagguaau aaggguatcg guttgguuat cgtgcgcgau 1200

<210>142

<211>1200

<212>DNA

<213>智人

<400>142

autuaaguau uaguaagcgg autcgaautu aaagggtttu agggtgtaga cgauuagagc 60

guautgaggg gutuuaggtc gguucgutuc ggagucggga gagtaaucgc gtguagggaa 120

aggcguacgg uaguutcggt guutuuuttu uutuuaucgg acgggtgaut gautaggggt 180

gaggtuutua uutuuaggut gcguagutga gttutggaag gtautgtuut gggggtgtga 240

gtgtgtgggu uutuaggaaa ggtgcgaggg gcggatgucg tggtutauuc gaguttgcgg 300

gggtgcggtg gtuaagttuu uuaggauuut cgutggcguc guttgtcgau aacggggaau 360

agtgggcguc gcgggtggtg gtaauttggu ucgggaagaa aauauatuuu tttuuuaaau 420

cggattuutu tgaguaaaau uagatggtgt uatucguatt ttauagutgc gtuaagagag 480

guuuaggaua uuaagaguua gutgtgguua gaguuutttu autgauuuag aauautgguu 540

utcggaaauu tggagaautg cgaggguttt taatgcggut gagaagaaag tgaagauuuc 600

gautuutuut ututuuttcg aaagagucga uauaggtatg aagauuagcg uutcggacgu 660

tucggggtag ggggucgacg uuuuutuuut ttuagaatua cguuttgutg atgutuagtu 720

utguuuagtg tuuauuuuuu auuuucguuu uuagtttuut ttutaguuuu tucggtuuuu 780

aaagcgaaut aagutagcgg uaguttutuu atuucggagg agautuuaaa utuutaggtt 840

tuuuauuttg gagagtautg ututggaatg cguaggggag cgguauutgg aaagggttgg 900

gcggaagutt utcggauuua gagggggcgg auauucggua ucgcgcgtgg gagggattaa 960

utuuauuuua utagauuauu tuuuuututu tuuuaggagu uauttuaauc ggttgtcguu 1020

uuagtggucg uuututgagu acgtgttaut guuagtutgc gtuagcgttg ggtaaataua 1080

tgautggucg acgucgucgg gtggggutat ttaagagaua gucguucgut ggtuutuuut 1140

gaauttggut uagutgucgg gutgutucgg ttggaaacgu uaaguuagut gcgtuutaat 1200

<210>143

<211>1200

<212>DNA

<213>智人

<400>143

uututtttuc gtttguattt tguuuuatat tagaatguta uuatutaaaa ucgutuuatg 60

aattagaaag tttaagttgt uagggautga atgtgtutgt tttuuaauag tttutgguag 120

ttuuutgutt ttatggtgta gtuatggtga aauutgagtu atutgaagat ggtgguagtg 180

uuagagagua ggagagagga gutguaaaga aguuagauag cgttggguat uaataautuu 240

tggguauuau cgguuautgg uuttuattut gauaggagag uuaauuuaau uutaautgtg 300

ttuagagatt gutuuaagut ttauagttut auuaaattut ttutgtagua aaaatataaa 360

gguatuttut taggtaattt tttttuaggg ttuuaagtag uaauauutaa cgtutguagt 420

gcgagttutu ttuttutttt tttttttaag gtgataaatu ataauatttt uutggaaagg 480

aaaguagtag auutuatttt ttgttttaag gaaaaatagt ttttutgttt uuattuatat 540

auattaaata autauuuagg aaatacguuu cggttttgcg cgcgtgtgcg tgcgtgtgtg 600

tgtgcgtgtg tgtgtgtguc gtttututaa aattutgaut uatagtutgg aggauaatga 660

ttgauttttt tuuauttuau atagttguta tgaatttutu utuauaagga tggguutgtt 720

tautuauuut ggguatcgtt ggtagagcgu tagtgtaaau aguutgagga auucggtggg 780

ucggggaagt gggcgcgutu tgttutucgc gguuagutgg gacgucgggu uaggtggggu 840

cguutgcgtt taguaautgu tttutuauuu uutggatttg cgatgtttgu uauaguagcg 900

agaagcguua ttgtaatggg gatgggaggg gtggaguutu uaagtuutgt utuaatttag 960

atututuaut utgutgttag gcgcguuuat ttuagattau taaautcgaa ttaagaggga 1020

aaaaaaatua gggaggaggt gguaaguuau auuuuacggt guucgcgaau ttuuucggua 1080

gcggautgta guuuagguag acgucgtcga gatguagggu uuaucgutuu tgaucgucgu 1140

uuauutuutu tgcgtgtgua ucgucgcgut ggucgtggut uucgggtagg aacgtgggcg 1200

<210>144

<211>1200

<212>DNA

<213>智人

<400>144

atgcgtgutg aagtatgtag gggtaaaatg auatgatgtu tggaatttgt tttaaaatau 60

ttuagaaaag cggggagtag gtgaaataag tgtgauaaaa uuttaatagt tgttgaagcg 120

gggtgatggg tauauaguag ttuattatau aattutautt ttgtgtatgu ttgaaauutu 180

tuaattaaaa aaagagggta gagagtuatu aagataattt autaaaagtt tuutgtaatg 240

tuuuuagaag auuuuuutaa utuauauaua uauauauuua uauauauaut guuttttgag 300

aautttutut agaagguuaa uuuagguagt uuuuuaautg taaggaagau tcgtgtatgt 360

atgtguatat gtguatttuu uuagggaaaa auatuuauag uttuuatgac gagaggggtc 420

gtgauuuutu uucguuaaaa gattaaggau utgcgatuut auagaucgga guuutgtttg 480

aagtutgcgt tguuuutuau utuaagutgg tuautgtgtg aagttgguut agaatuuuuc 540

gguuuutggg aguttgttuu tucguutgta aaatggggut guagggucgt uuacgcgguu 600

aucggaagga uaaggtgttu aggucgutag gucgutuuut gguaagcgat tuuuautcgu 660

agcgcgguut cgauuutcgu uuaagacgcg uuutucgcgu uuuuauuuuu tuuagguuut 720

gguuagtuua uutuucgutt ggggcgguaa tttgtutuut tttgaauuuu ucguuuucga 780

cgggtttuuu uutttgattc gcgguucgga gguttuuuuu cgutttgaaa tguaaauucg 840

uutcggutgg ggucgcgggc gguucggagu tataaaaggu utgggtgggg cgggcgcggc 900

gguaggauag ucgagttuag gtgagcggtt gutcgtcgtc ggggcggucg guagcggcgg 960

utuuaggguu uaguatgcgc gggggauuuc gcgguuauua tgtatgtggg utatgtgutg 1020

gauaaggatt cguucgtgta uuucgguuua guuagguuag uuaguutcgg uutggguucg 1080

uaaguutacg guuuuucggu uucguuuucg gcguuuucgu agtauuucga uttutuuagu 1140

taututuacg tggagucggu uuucgcguuu ucgacgguut ggggggcguu uttuuutgcg 1200

<210>145

<211>1200

<212>DNA

<213>智人

<400>145

aggcgutuat ttaaaattuu agtuttgutu ucgagggutt tgguutuuat uttuauuttt 60

aacgaucgag ggutggtggc ggcggutuut tuutgututg cgauaggtgt cguttutgag 120

cgggagtttt ggguauagau atcguagatu cguauuauuu utaggggtut guatgggttt 180

uagutguauu uaguutggag gggutttttg gaagggggua cgtgggcggt gggagcgggg 240

aaguaggtga ggggaguucg uutgcgcgga tttttutgut gtaaatuaga uuuauagtut 300

uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt utaatuutut ttggagaggg 360

ggttaggaac gtgucgaggu cggagucggg agcggggtgg gtuucggcgu utgtgaaucg 420

agtgggggag cgggucgcgc gutguuutga agauuutguu tucgcguuut tgggggutcg 480

ggguuuagcg uuttcguagg cgagcggcgg cggutggutu tguucggggt gcgcgggggc 540

ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu uucgautguu cgutcggucg 600

tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut gucggggcgu uuuucggtuu 660

uuauuutuau ucggcggutu aggautagtu uuuuaauttg ttututgutg ttaautagtc 720

gcgutgucgg aacgatggga tggggttguu auaguaauua gautggacgt uauaatucgg 780

guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg cgutgucguc guuauuutcg 840

gucggutgcg ggautcgggu tgcggggcgc ggtgggagga gcguucgggu tttgcgggga 900

guaggutaag gcggucgaga gaaagggggg tcgagacggg ggggtggagg tttggggggg 960

tgggggggua ggcggucguu atuttutcgu cgaggucguu tcguucgucg cgcgcgucgg 1020

tucgguagcg uacgggttaa ggutgguauc gcguucggcg ggaggggggg cguuuauutu 1080

uuutuutuuu cgcgucgggu atgcgggguu uagtggguau cgaggaggag utgucgcggu 1140

tgttcgucga ggagatggag aatgaggacg agatgtuagg tgagcggggc gcgggtgcgu 1200

<210>146

<211>1200

<212>DNA

<213>智人

<400>146

uututcgguu tttgutgtua uuaagguuaa aggaaggutg gutgtgtggt gtauuttgua 60

uutuuagaat guuttuaggt gtgatgtggu auuauagatu tggtaggtgg aggaaggggt 120

ggguuatttt auagatggga aaguaggutu tggagguttg gatgagtttu cgaggauagg 180

tagtaguaaa gutgggauut gutatuuuua uuagagutgt utuuutgaat uagtuauuuu 240

cgauuutgtu uagtuagaua guaucguutu uttggagggu uaaggutgut uuuauuuatu 300

tuaggguucg agtggtgtgg tttgtggutg ttgtatttut tguutttguu aguuaguagu 360

tuautgtuau uutaguatut gtuaggguuu utguagtgtg tutgtgggut guuagagatg 420

ggguutuatt gtuuuaguut agacguacgg tguutgggtg uaguuutguu ucgggtgagg 480

gatggtggat ggggutgucg tgtuuutggg utuuaguaua gggutuatgu tuuutgagtg 540

uttggggatu auauagtgat gtgauututt ttuagggggu aatgggaaga uutaaggtag 600

gggaagtuua gaatutuatg ttutgutuuu tgututgutg tuuuttgucg agtggguutu 660

agtttuuuuu tutgtuutat guauatggua gtutuauuta cgutggutua gatattutgg 720

gtgucgataa gttuauuatt gagtgaaagg guuacgtggt utuauagauu uuuautguuu 780

atutuutgtg tguatgauuu atgcggutuu tggggacggg gtggatgtua tggcgtuauc 840

gtggtautgt tutgauttgg ggguagtggu autgatggga gggaguutgu atgguaguut 900

gutgtuatgg gaguutuagg gtgggguuut guagutgagu uuuauuttgg ggauuuttut 960

utgtuuauag tguuuuuuau tgaaggguaa agtuuagcgg attutauaut ggaggtggac 1020

ggaguuuuut guuuuuttua tggtggggut gucgggguut gacgtggagu uuaguutuuu 1080

tuuauutaag uuuutggagg guatuuutga gagagagttu tttgtuaagt ggguagggut 1140

gtuutautgg uattgutuut gggtgaagga gutauaggtg agtguucggg agggtggutg 1200

<210>147

<211>1200

<212>DNA

<213>智人

<400>147

cgauaggtgt cguttutgag cgggagtttt ggguauagau atcguagatu cguauuauuu 60

utaggggtut guatgggttt uagutguauu uaguutggag gggutttttg gaagggggua 120

cgtgggcggt gggagcgggg aaguaggtga ggggaguucg uutgcgcgga tttttutgut 180

gtaaatuaga uuuauagtut uuagagcgtu ttttuuuuaa gtgtggaaua uatttttutt 240

utaatuutut ttggagaggg ggttaggaac gtgucgaggu cggagucggg agcggggtgg 300

gtuucggcgu utgtgaaucg agtgggggag cgggucgcgc gutguuutga agauuutguu 360

tucgcguuut tgggggutcg ggguuuagcg uuttcguagg cgagcggcgg cggutggutu 420

tguucggggt gcgcgggggc ggtgtttuut cguutuuuuu tgcguucggg utcguuaagu 480

uucgautguu cgutcggucg tcgggtucgc gggcgcgcgg acguutcgac ggutuuuuut 540

gucggggcgu uuuucggtuu uuauuutuau ucggcggutu aggautagtu uuuuaauttg 600

ttututgutg ttaautagtc gcgutgucgg aacgatggga tggggttguu auaguaauua 660

gautggacgt uauaatucgg guatgtgtgu cguuuuuucg ucgtgucguc gtguututgg 720

cgutgucguc guuauuutcg gucggutgcg ggautcgggu tgcggggcgc ggtgggagga 780

gcguucgggu tttgcgggga guaggutaag gcggucgaga gaaagggggg tcgagacggg 840

ggggtggagg tttggggggg tgggggggua ggcggucguu atuttutcgu cgaggucguu 900

tcguucgucg cgcgcgucgg tucgguagcg uacgggttaa ggutgguauc gcguucggcg 960

ggaggggggg cguuuauutu uuutuutuuu cgcgucgggu atgcgggguu uagtggguau 1020

cgaggaggag utgucgcggu tgttcgucga ggagatggag aatgaggacg agatgtuagg 1080

tgagcggggc gcgggtgcgu utgggguuag agcggcgggg gcgucgagac gggucggguu 1140

uagggcggag cgcgggcggc gggggcggcg cggucgggut ggcguutcgu aggaggggua 1200

<210>148

<211>1200

<212>DNA

<213>智人

<400>148

guatgaaatt gagataaaau atttuaauag autggauaga ututgaauau tgttgaagag 60

aauattgata aattggaauu tggtgutgag guattttuuu agaatguaat gtauagagau 120

aaagataaaa uagggagaau atggaagaua uuttgagatg utuuaauaat uatuuaattg 180

gagttguaga agaaauagaa aaaatggtga agaagttgga tttgttgaga gtttguagau 240

utggagagaa atgtgaggtu tuagatutgg agtguattut ggaataguaa guaagataaa 300

tataaataaa tgaauucgta gauacgttag aauututagg tautttagau utagtauuta 360

uaaaataagg guaguuagat cgttutuaga uttuttaaua auaauaggtg guagagauua 420

tgguaaaatu tucggtguau tgagggaaaa tgtgtgutga tagttttata tuuagutaaa 480

ututututcg agaataaagg gaattatacg gggtuatggg agutuagaag ggautguutt 540

tuttttutta tggggaggag tgaaatuagg gaagauatua uagaggtgat gtttatgttu 600

uutagguagt aagggggtgg guattuuagg aagagagtua ggtagtttgg aatggutggg 660

ggutgtgaag gaguautcgt uutguagcgu uttgaataua ggguagtgag atggaautta 720

attutgtgtg gtgggaguag gggaggutua tgtuagaguu utgatttagg taagtggutg 780

tggggutagg uaggaggatg gattggutuu aaggggtgag gttggaagut ttgttuttuu 840

uuagagtuut guattggguu tguutgggtu uuagutgtut uuuuauutag uagguagutu 900

tutuutuuuu tguutgtggc ggggtuuucg uuuatgguuu atgggguuuu ttgutuuttg 960

guagttuutu acgtguucgt utuuuutgua gatgauuaag atgutggauu tuutggagga 1020

uttuutggag tacgaaggut auaagtatga gcggattgat ggtgguatua ucggggguut 1080

ucgguaggag guaatcgaua gattuaatgg tauuuuuatu utguuuaagg gttutgattg 1140

agautuuttt ttgguututt utuuuagguu tggttuttag uuaggtuauu uagutggtgt 1200

<210>149

<211>1200

<212>DNA

<213>智人

<400>149

gaaatutauu tatttgtaau tuuagggaag taaatgagat aatgtttgga agatatutag 60

tutauuagut gutuaggcgg ggggcgaagg ttutgttuuu tgtuuuttut utatuaaatg 120

gutttaaaat uagaagaaag tattacgggt aggaaatggg autgcgaaaa aaatggaggu 180

tgattutggu utaaaggata uttatututa tauaaagggu ttutgattua aagagguuuc 240

gggattuaaa aauauaagua gagutauauu acgtggggtt tgggacgagu tgaattucgg 300

ataaagatgu utgtaaagag gagttgatgc gaatuuagaa aaguauttga aatguuuagg 360

utttguatgg uauattuuuu aggatttttt cguaucguat ttagaggttt agacggagtg 420

agutcgaatu agguuaaaag uuttaggtta utuutgggcg guagcggggu agaggtuaga 480

tuaauaggtg tggaaggutg cgaggtgagg gaagaaguag gtgtcggtgg agguuuuagt 540

tuutucgguu uagaggutuu aacgutguta ttggtgttuu aguagcgggc ggaggggtuu 600

tguucgguat utgggcgcgu tggguuuaga guucgggagg agguagacgg aggcggcggg 660

tuagcggcgg guuaguuucg gtggguttuc gutuuuutuc gucgguucgg tucgguucgu 720

cgcggaggat guutggaggt tgacgtgaat gguutgtggu tgggaaguuu uuaggcguuu 780

tguutaguuc gggggcgggg ucguutaguc gucgguuucg gtggcgtgag ggutggggcg 840

ggggucgggg auutcgcggg gagggagcgg gagggaaagc gguuuucgcg guuuttuaat 900

tggucguauc guuuutcggc guagaggcgg gaggaggcgg uuutuuattg gtcggguucg 960

gcgguuaatu utcgaagguu uaggcggagg cgggggcggu utgtggggaa ucgaggtgcg 1020

ggcggcgagc gagguagucg ggtguttcgu agcggagutc gaggututgt aguauuuagt 1080

tggauuuagt cguuuaggua ucguucgcgu uucgcggucg tutuutgcgu utuuuagagg 1140

agggagttcg aguatuuuuc gcggcgguua utuutcgggg uuaggagcgg ggaagcgaag 1200

<210>150

<211>1200

<212>DNA

<213>智人

<400>150

gatutuaggg attgaaatut gtuutaggtg tguauuagaa agtggtggua agagatgaag 60

uttcggagga ggutgauutc gguuaggatt uttaagtutu aaagtttuag utttutuauu 120

uutuaacgga uatgaaatut auutatttgt aautuuaggg aagtaaatga gataatgttt 180

ggaagatatu tagtutauua gutgutuagg cggggggcga aggttutgtt uuutgtuuut 240

tututatuaa atggutttaa aatuagaaga aagtattacg ggtaggaaat gggautgcga 300

aaaaaatgga ggutgattut gguutaaagg atauttatut utatauaaag gguttutgat 360

tuaaagaggu uucgggattu aaaaauauaa guagagutau auuacgtggg gtttgggacg 420

agutgaattu cggataaaga tguutgtaaa gaggagttga tgcgaatuua gaaaaguaut 480

tgaaatguuu aggutttgua tgguauattu uuuaggattt tttcguaucg uatttagagg 540

tttagacgga gtgagutcga atuagguuaa aaguuttagg ttautuutgg gcgguagcgg 600

gguagaggtu agatuaauag gtgtggaagg utgcgaggtg agggaagaag uaggtgtcgg 660

tggagguuuu agttuutucg guuuagaggu tuuaacgutg utattggtgt tuuaguagcg 720

ggcggagggg tuutguucgg uatutgggcg cgutggguuu agaguucggg aggagguaga 780

cggaggcggc gggtuagcgg cggguuaguu ucggtgggut tucgutuuuu tucgucgguu 840

cggtucgguu cgucgcggag gatguutgga ggttgacgtg aatgguutgt ggutgggaag 900

uuuuuaggcg uuutguutag uucgggggcg gggucguuta gucgucgguu ucggtggcgt 960

gagggutggg gcgggggucg gggauutcgc ggggagggag cgggagggaa agcgguuuuc 1020

gcgguuuttu aattggucgu aucguuuutc ggcguagagg cgggaggagg cgguuutuua 1080

ttggtcgggu ucggcgguua atuutcgaag guuuaggcgg aggcgggggc gguutgtggg 1140

gaaucgaggt gcgggcggcg agcgagguag ucgggtgutt cguagcggag utcgaggutu 1200

<210>151

<211>1200

<212>DNA

<213>智人

<400>151

gggatggagt attguaguut utcguuuuau agauttgtga auagggcgtg gggauagaua 60

uuuagutuut aggguuatgu uauuuuuauu uutguucguu tutcguagua uutttuutgt 120

ggatutgauu uuuttuuaga uauagaagta aguuaguauu uaguagauau agggtuauut 180

uuuagutuuu tauuagguaa gagcgauuag gguagggaut gatautgucg aauuuaggag 240

uuagguucga uuuaguutua ggtuuaguag gtuucguutg tuuauutggg uuagguutag 300

aguucgggag uuuutggutg gtgggagguu auucguaauu uauuuuauac guagutuuag 360

utuuuuuauu aggcggggcg autaggauag ggauagaauu cgttgaauuu aggagtgaga 420

tucgguuucg ggtuucgutg gguuutuucg tuuauuttgg utggauutgg cguutgggag 480

auuttggutg gcgcgagguu acguuuauua gauatguagt tuuagutauu uuauuagutg 540

ggcgauuagg auagggacgg aggutgutga guuuagttag agguutguuu uucggggtut 600

gtuutgggcg utuuuuuaag gacggauagg guagguaggg tucgggacga tggucguaua 660

gtuucgguuu cgtgttuuua gguucgtutt gutuutcgat gtgagggaga uucgggggat 720

gggauaggut ggguuucgua gtguutgaut uuutguaggg utuucgggau aggggtucgg 780

cggauagucg gutgutuacg ggtgaggggt uuaagutggu attgcgguua uuttucgguu 840

cgggututut tggggagggg cggggttggt gagaaucggt uacgtgutuc ggggutuaut 900

cggggtutuu uagggucgga agtaggguuu utgtgcguag gcguuutgag gatuucgggu 960

tguuuatutu acguuagggg gcggaauttu utguaguutu tutguutucg uatuutcgtg 1020

gguuutgauu ttutututga gagucgggua gaggutucgg aguuatguag gucgaagguu 1080

aggguauagg gggttcgacg ggcgatgutg atgguuuagg agguuutggu attuutgatg 1140

guuuaggggg uaatgutggc gguuuaggag aggcgggtgu uacgggcggu agaggtuuuu 1200

<210>152

<211>1200

<212>DNA

<213>智人

<400>152

ttguaguutu tcguuuuaua gauttgtgaa uagggcgtgg ggauagauau uuagutuuta 60

ggguuatguu auuuuuauuu utguucguut utcguaguau utttuutgtg gatutgauuu 120

uuttuuagau auagaagtaa guuaguauuu aguagauaua gggtuauutu uuagutuuut 180

auuagguaag agcgauuagg guagggautg atautgucga auuuaggagu uagguucgau 240

uuaguutuag gtuuaguagg tuucguutgt uuauutgggu uagguutaga guucgggagu 300

uuutggutgg tgggagguua uucguaauuu auuuuauacg uagutuuagu tuuuuuauua 360

ggcggggcga utaggauagg gauagaauuc gttgaauuua ggagtgagat ucgguuucgg 420

gtuucgutgg guuutuucgt uuauuttggu tggauutggc guutgggaga uuttggutgg 480

cgcgagguua cguuuauuag auatguagtt uuagutauuu uauuagutgg gcgauuagga 540

uagggacgga ggutgutgag uuuagttaga gguutguuuu ucggggtutg tuutgggcgu 600

tuuuuuaagg acggauaggg uagguagggt ucgggacgat ggucguauag tuucgguuuc 660

gtgttuuuag guucgtuttg utuutcgatg tgagggagau ucgggggatg ggauaggutg 720

gguuucguag tguutgautu uutguagggu tuucgggaua ggggtucggc ggauagucgg 780

utgutuacgg gtgaggggtu uaagutggua ttgcgguuau uttucgguuc gggutututt 840

ggggaggggc ggggttggtg agaaucggtu acgtgutucg gggutuautc ggggtutuuu 900

agggucggaa gtaggguuuu tgtgcguagg cguuutgagg atuucgggut guuuatutua 960

cguuaggggg cggaauttuu tguaguutut utguutucgu atuutcgtgg guuutgauut 1020

tutututgag agucggguag aggutucgga guuatguagg ucgaagguua ggguauaggg 1080

ggttcgacgg gcgatgutga tgguuuagga gguuutggua ttuutgatgg uuuagggggu 1140

aatgutggcg guuuaggaga ggcgggtguu acgggcggua gaggtuuucg gggcguaggg 1200

<210>153

<211>1200

<212>DNA

<213>智人

<400>153

ttgtgaautg uutgtggaua ggguaauatg guagagaaut gaggguagut tttataauaa 60

attaagagat ttuttaatat ttaauuutuu ttauattaau tgutcgtggt atattattut 120

ttttaaaaaa ttatttatau tttttgtggg tauataatag gtatacgtat ttattggata 180

uatgaaatgu tttaauatag guauauaatg uataatgatu auataatggt aaatggggua 240

tuuattuuuu tuaagcgttt atuutttgtg utauaaauaa tuuaattata uttttagtta 300

tttttaaatg tauaattaaa ttattttgau tgtagtuatu ttgtgutatu aaatautagg 360

tgttaataat uauatuatgg agaatggagt atuuatuuut uaagcgtggt guattautut 420

ttgaatatgu tgututggat tgtatttgut aatatgtggg guttututat taatgttgua 480

aaatagggag uuaataatut ggttgagaga tgaaaguagu aguaggaaaa tgtgttuaua 540

gaauutuata cgagtggcgt utaggguuaa ggutuuttga atguatauuu aagggutgat 600

gagaggtggg gacgagtgut gucgaaggau tuutuaauta uuagaautac gtaggguuuu 660

taauatuuuu tcggagcgag utuuucgcgu uucgtauauu auuaggtutu uutggttuut 720

utuutgutuu ucgtuucgut auutuaggaa autttaguuu aguututucg atauaagucg 780

guutuuttga gggutttagg uuuututtcg uuagtgtata uuuuacgaua cguutgcgta 840

utagggauua uucggutttg tgggcggagt uuatgagagg gttggaguuu cgutcgtggu 900

uucguuuauu uaaguutagg ucgguuttcg tggauacgua tttucggcga cguutcggta 960

utgauututg uagagucggg tggaguuuat tgacgtuuag cgaagcgagg aguagcgatg 1020

gacggtcggg tguagutgat aaagguuutu utgguuttgu cgatucgguu tgcgacgcgt 1080

cgutggagga auucgattuu utttuucgag acgtttgacg gcgataucga ucgautuucg 1140

gagttuatcg tguagacggg utuutauatg ttcgtggacg agaauacgtt utuuagcgau 1200

<210>154

<211>1200

<212>DNA

<213>智人

<400>154

tcgaatutgu agtgagtgat cguauuautg uautuuaguu taggcgauag aggtuaaaaa 60

uaaaauaaaa gaaaauaaau aaaaaaaaua taguaaauat uuagaagaut gtgtagagua 120

atgaatgtut utuaaguuag tgatuttttt ututtuattt ttuauatuag gtgggtagtg 180

tguuuauttc gtaauaaggt ttgagggagg uauatttgau auaagaguat gaaaauuuaa 240

tuauauttat gauttauaaa aggatuaagt uagtgatutt taagutgtgg guuattaaat 300

auattttgtg agucgagtgu agtggutuag guutgtaauu uuaguautat gggaggtgga 360

ggtgggagga tuauttgagt uuaggagttu aagauuaguu ttggguaaua tautgggaau 420

tuuuatutut attaaatttt ttttttttaa ttttgtggat tauaauuatt tuaaaaauta 480

aaataagcgt aaatgtatua aaatguagut tauatagcga ggataaatgu tgttttgtua 540

atutgttgtt tuaagttttt tatgtgtgga ttgggtuauu ttgtaauagt gauttauutt 600

tatgggtuac ggttgaaaau atttucggtg uagtggutga utgtaatuuu aguautttgg 660

gaggucgagg utggaagatu auttgaaguu agaaguuaag agttuaagau utguutgggu 720

aauacggcga uauuucgtut utatttaaaa agaaaaaaaa aagtttuuaa gguautgaga 780

tguuaggaau ucgaggtgtg tgtuuagtag gggagggagu aaattgggcg tttggaaaaa 840

gtuuuacguu tggaaaggaa tauauagtgg gggggtgggg ggcgggguau atcgautaut 900

tuaagguaua utuuuacggt tuagaaaauc gattggutaa aautgggaaa gtuucguuua 960

uaacgutuau tgguuaatgg utgcgtgaaa tuagtgcgaa gtgggcggga tagagagcgt 1020

gggcgggggg gutaguutcg tgcgggutuu ttaagtagcg gutgcgtggu ttuuutggua 1080

cgutaututt acgacgtuac ggtuaggtgg tguagagutg gacgguaacg acgtcggacg 1140

cguuuuttut tggaauaatg tuuuauuacg gaggagutuu uaagguutut acgtgggtcg 1200

<210>155

<211>1200

<212>DNA

<213>智人

<400>155

uutuuagttc gguattagtt tuttuutaat gtuuaututg uucgaagtga uaagcggggg 60

uatgtggaga utuagutuua ggttuutgga cgggutuagu uauuuuuaga aagutaatga 120

atgutuaauu aggguttuua gatguuuagg ggauagagua ggagatgucg gggaatgggg 180

utttuuttgu agttuaggag gguuutguuu uagguuuaga agtagaaggg aaagcggutg 240

ttttggcggt aaauagtaat gtggggagtg utguagagaa agguagtutt ggggtttuaa 300

gutggagagu agtuagutau autuaggauu tutgguuatu uutguuttua uutgutgttt 360

gguutgatcg tutaauttut utgattutuu autauuuaut uuttattacg tttttgagau 420

ttgtuaaagt tttatattag ggutaautgg gacguataua aatutggtaa uttcguuagg 480

gcgggaagtt aggaaggagu agagutggut guaggtgtut ggtuutgauu autuututat 540

guuauuuttg aggaguttgu tgautttutu atgacgttut uuuattuuag gagutguaag 600

tgcgttatuu tggutggagu acggtgtuaa tuacgguaga utaagguuag cggtgatggu 660

ttgaatguua ggutgggggu tgggattttt uutgaggatt tuauaggaua gaggttggut 720

tggaaagauu aaggtgggau tgaggaauat tuuuuutauu uuuaauutcg gtgggutgtt 780

guaaguutgg agguuagaga agacggguut gggatgucgc gggcguaggg guagguagtg 840

aaggagatgg utguuttcgg tagagutggt cgutgaggua gaagaggagg gcgtggggcg 900

tggggcgtga ggtggucggc guuucggutg guuaatgguc gggutgcggu uuutucgcgg 960

ggcggggtgg guutggtggg cgggcggggu tcggggcggg ggcggagagg gaguutggtg 1020

ggcgggcggg gcgcgtuttg cgggutuuut cgggtaucgg cgutgucgua uuucgucgcg 1080

utuucguauu cgcgguucgu uuaucgcguc gutuucguat utguauucgu aguucggcgg 1140

uutuucggcg ggagcgagua gatuuagtuc gguucguagc guaautcggt uuagtcgggg 1200

<210>156

<211>1200

<212>DNA

<213>智人

<400>156

guautauagu utgggtgaua aaguaagaut utgtutuaaa aaaaaaaaaa aaaauaaaaa 60

aaaauaatta atguuutcgg gtaaautatg acgtttgtgu taauttttua gatgtuuuaa 120

gatttgggtt gttttauaag gataacgaag ttuatgatga ggttaaguaa tuautgaagu 180

tagtgutaga aatttttttt aatttaattt tttagaaaga ggggtuttgu agaatttttt 240

atttaatttt ttagaaagag gagtutcgut atgttgutua ggttggtutu uaautautgg 300

gutuaagtga tuutuacgag tagutagggu tauagguaua ggauautatg uuagguttag 360

tgutauaata ttutgtutat tttautttaa aatattutaa gtatgutuau tttggaaggu 420

atuaauatuu agaaatguat tuutauatua agaututuaa gaaacgggaa ttautgtaag 480

gguatauuut tgaguaauua tuauautgua utgaaututt gagaatattu tggaatatuu 540

tggaaguatu tutguagggu agagaagtga autguuauag aaggaguagu tttggggaga 600

agaaatauag tttguututt auagtatttt tutauaucga gagutauatt uutuucgagt 660

tttaaatttg tggaucgttg aatatuautu cguutttuat aaagttauaa atauuttucg 720

tcggtggcgg gaauagagtt tggaaaatta uatguutaag auttuagata agutaaatga 780

uatauatgua ataguatuuu atgaagaatt tattuaauuu aatuuattgu atutaattau 840

uuaaaguaua gaaaututuu aaautgtgua uuuuuuaaaa ggagggaaaa tguaaggttu 900

utgutguagt tuucgggaua uautgcgagu cgutttgtta uaagtgtatu uaatgtuuuu 960

agaacgaggg auttgtgggg cgcggutuat uuuagcguua uttgututgu agutuuuaga 1020

ggtggtggtt gtgttacgaa ggutgauuut guuaatgguc gauaaaatgg tgcguauuuu 1080

uaagtgutcg agatguagga auuatggutt uutggtguuc gtuaagggau acgcggguaa 1140

atgucgutgg aaguagtguu tutgcgagaa gtgutauutg atutucgagc guuagaagat 1200

<210>157

<211>1200

<212>DNA

<213>智人

<400>157

atatatatat gtgtttatat atataatata tattatattt gtatauauau auauatatat 60

guuauatttt utttatuuat ttatuuuttg atggauautt aggttgattu uatatuttgg 120

uaattgtgaa tagtgutgua ataaauatga aagtauagac gtututtuaa uauautgatt 180

tuaaatuttu uuagtaaata uuuagaaatg agattgutgg atuatatgat aattutautt 240

tuagtttttt gagaaauutu uatauaattt tuuatuatgt ttgtautaat ttauattuua 300

uuaauaguat auaaguattu uuttttutuu attuttguua auauttgtta tuataaaggg 360

aggtttgaga gauuataaaa uaaauuuuau utuauaattt tgttagtgua agttutattt 420

gguutattuu uaauautaag uauauagtag gtgguaaata tttgttgaat ggatgaattu 480

tuatttttut uuatttgtgg aaguagauau utuutuaaaa aaaaaaaaaa atucgaaaga 540

aaaggtaaag gaaauagttu tatgaatggg ggttaattta ututuutagu attuauttat 600

tgggaaaaaa agtaauagua gtttutagaa uuututggtu tutgagggag atgutgtgtt 660

uuuutuutua gagaagaaga aaacguauta gagagtggga guatuuuuaa ggutgaagcg 720

uatuuaggau atuauatgtu aacgtgtuut ututggcgtg gggtuuucgc gagtutggga 780

aacgaggagu tgguaaggga ggguaagcgg gggcgguaaa gaggguuuut ggaguagggg 840

gcgcggauut cgutgcgutg cgcgututau cgucgggutc guaacgutgg gutuagcgut 900

cgcguutuuu tuagututut uutucguuuu uuttcguuut uuuuutttuu utuuutttut 960

uutuutuutu utgucgucgc ggucgutguc ggauttcguu agatuagauu uacggggutg 1020

uuutuuuutg cguautuuuu tcgutguucg gguucggagc guagcgcggu cguauaggta 1080

ggaguuuuua acggggggtc guuucgagcg aguuuagtau tuautggguc gcgcgcggga 1140

gagtgaggtg gggtgagutg aggggtgttg agtauucgag aautguuutg gautgtguag 1200

<210>158

<211>1200

<212>DNA

<213>智人

<400>158

gagaagutut gagauatgtg agaaggtuta gtattutaut agaautggaa gattgututu 60

cgagttttgt tttgttattt tgtttaaaaa ataaaaagut tgagguuaag guaattuata 120

ttggutuaua ggtatttttg utgtgutgtg uaaggaautu tgutagutua aggtgagtat 180

autgggaaag uuttaacgtt utagagaaua gagttttgua guuuuauutu uatuuuucgg 240

ggtgtgggau tgggggguag gaaatguauc gtuuuutttg aaatggatta utgttttttu 300

utttcgauuu uututttutg uaguutgutt tgtaggtgua gtataaaatg uacgutgaat 360

gtuttttgta tgtaaauagc gtaguaggat ggagtaacgt gaaatguaat tutauaguag 420

tttttacgtu tttgutguut cgttcgttgg utaucgagaa ggttuaggag ggggagggga 480

gatgagaaag uagattggaa gttgagtatg gtggaguutu aguututuuu auuutuuttt 540

uutcguttgt gutuautgut aaagttttgt tautttuuuc guaguagata utaaauatta 600

gtttgtuutg tattttuttt gagattuaua atgttgaaag uuuttttuut aautatgutg 660

aututggcgu tggtuaagtu auaggauauc gaagaaauua tuacgtauac ggtaaggggt 720

gatggaattt gaaataagta cggttuagcg ggattutgtg auaaaaaaag autttauaua 780

uuuutguuag tgtatttggg utataututg utgagggtga taaattaaau aauauttuat 840

tuatguttua tatutaagat tcgttgtaaa ttguuuuutt gatuutttua aaagttuatt 900

gggutuauua uutaagatag gaauuaauat gtaatuattt gtguagggut aaaaatggga 960

tucgttuaaa aautaaaauu aaagaaagtt auatgtttuu aaaauattua auaaattaat 1020

gggtgtaagg aautggaaaa uutggautuu tauuauatgu agataaaauu aatacgtgua 1080

gaataagaut uaagtuaagt aagaacgtta aauauuataa agauauatgg uuttutttgt 1140

gtauatgaua tguattutua agtaagtggu utttattgaa tttataaagg utatatattu 1200

<210>159

<211>1200

<212>DNA

<213>智人

<400>159

cggutaggtc ggagcggaga gtcguaguag ucgutucggg uaguttuuua gtuucggtut 60

guuttgtutg tgcggutgua agtuuucgua uuuauautta aguutttuau ttutauuuua 120

ucgutuuuag acgggutagg uucggttuua gggautguuu uuaauuutgu uuucgggaaa 180

tuuauaautg gttuuutguu uaagguuatu tcggggcgtu utggguuutg ggcgaggtuu 240

acggcgtgtg uagggggacg ggguuagcgg ggauttuutt autgutagaa agtuattcgt 300

tuagtututg gagauagtga cggaguuutg utgcggautg gacgttgggg auuaagtagg 360

tuuucgutut uuagguatut ggggaguuag ggaagaagcg agtgatagag uuauaaaaut 420

uuucguaaag agtatttuag agggggaagc guuataaaga uaaaauaggg uaaggtggua 480

gagggtggcg gtgguaggcg cgagtutgua gutuaguucg ggcgcgutgg acguagauac 540

gtcgaututu utaaagaagu aaucguaggt uaguttagau ttuttttatt tuaataaaag 600

agcgttttuu tuuatuttaa aucguucgtg gtgggagaaa aggtttuuaa uututtutut 660

ggutuuuutc ggtuaattuc gaguttttuu aaagtuuutu cgucgtuuag gggutcgauu 720

ttcgaggtaa cgtgggggat uucgutggut uuutucggua ggcgggggcg gggaucgguc 780

gtgutcguuu uutagaguuu cgggagaucg cgcguuucgt ggaguucgga gggggcggaa 840

uuutggggcg gguuutgutc ggtgaaggcg gggutcgguc guuutgtutg cgucguuatt 900

ggucgcgggu uucggautgg cgggutuacg tuaucggucg gguucguuuu uttgguaatg 960

tuttuaguuc gutgututuu taauttaagu atttattuua utgggataga agcgguagga 1020

guagcgttgg uaucggcgaa uuatggutgg gattttutat ttcguuutat tttcgtgtut 1080

uttcgggatt tgcgacgutg tuauaggttu uagggtatau uucgcgaatg aaggtaagag 1140

cgggacgguu tttutgtggt cggggauagc gagggguuat cgcgggtgag gggtuutuag 1200

<210>160

<211>1200

<212>DNA

<213>智人

<400>160

aauuutgtgg agatagguaa aataagtata auuuuatttt auagttgagg uuauuuautt 60

aataaauaag tgauaaaguu aagtttuuag tattuutuaa gtgttttuut ttuaggutut 120

aaattgutga uttaaatgtu atuattagag agagttgtut uutcggtaga agtauaaatt 180

ttgttuuaga gtuaaatatg aagauttgat uagtgguutg gcgcggtggu tuacguutgt 240

aatutuagua utttgggagg uuaagguagg cggatuauut gaggtcggga gttcgtgauu 300

aguutgauua auatggagaa auuucgtutu tautaaaaat auaaaattag utggguatgg 360

tgguauatgu utataatuuu agutautuag gaggutgagg uaggagaatc guttgaauuu 420

aggaagutgt ggtggcggtg aguuaagatc gtguuattgu autuuaguut gggtgauagg 480

agtgtgaaau tutgtutuaa aaaagaaaaa aagauttgat uaguttatag uutttatuat 540

utagtuttut attututgga gagtuagtgg ggaututtuc gagttuttgt aguuttttut 600

taagguutat aggaagtuat utgtgutgag uutguauttt utataauaga tggaaaautg 660

aagutuagau atuttaagtg guattgautt agautataga gutagttagt gggggguuag 720

uauuatgauu tgguuuutau utuuaguagg uttuauuuau uuttguauuu ttguaggaag 780

uauttagagg uttgaggttg uuagutgtgg ggggttgggu utgtguagtg uututuaguc 840

guuuacgutg gtggggutut guagtgttag uttuttgttt ututattttu tauutaggtt 900

tuagtttttu auttgggttt gtttuuuutt tgtututggt tuaguttuut tttuutgttt 960

ggttttaagt aggutataaa aatuaagttg utgtuttuag agggtutgtg gtuututgat 1020

uaauataggu tggtgggagt auaggautcg uutuutuagg gttuuutgtg utguuauttt 1080

tuaguuatgg uuauaaggtg agtattggaa uuagtguagg ggauagaggg atgtuaagag 1140

gaaauutaga atuttaacgg tgaatgggut gtagaaatta tutuaggtuu uuttagtata 1200

<210>161

<211>1200

<212>DNA

<213>智人

<400>161

uttttaaatt tgtttututt uuuutttttg ttaaagtaua aaauaaaaua uuttuuuuua 60

uttttcgaat agttttggut gtgtutttag gautggaagg aaattuagut uaaatgaatt 120

autatattat gaauttaagt aagaattgtt gtguattttg tauagaatgu aautuutagg 180

agttgauaaa tgtttgttaa gtguatuagt gagcgauata ggauuttutu utuuutautu 240

tuttgtuacg gtttttattt aatuaaauat ttattattgt tcgatgutut taaatguuat 300

ttuuttuagu tgattatttg tatgauagaa gagtuaatta agutattttg tuutaaaaat 360

tacgaaaacg aaatgtauaa ttgtgaagta aaattttgtt uutttguaaa ttttaataaa 420

ttattgaagt ttattttttg tttuaaataa tutggguttu agttutaata atggaaggau 480

aatgtgaagg uuuagaattu aguatagcgu utgguattaa taggaggtua gtauattttt 540

agtauatgtt tutuaaatag atuttaaaat ttuatttaag agcgtttuut uacgtuauag 600

tatgtututg gcgttautta attttgaaaa auutuaauau agattutagt tttagguaaa 660

gutuagaaaa tttutautta aggatatttu uaaagcgaaa ggaagcgcgg agacgttuat 720

gautgguatu atutcguacg tggttucgga aattutcggt aggatguuut auatutgutu 780

tuuutuuaut aagaagaauu tutttgtgtg gcgaaagtaa aagtattagg guttttaagt 840

tguuuagagt uaaggaauac ggataaagac gutgggagat tgauatguat ttcgauuaat 900

aguattguag agaggcgtat uatttcgcgg atgttuuaat uagtacguag agagtcgucg 960

tutuuaaggt gaaagcggaa gtaggguutt cgcguauutu atggaatuuu ttutguagua 1020

uutggatcgu ttttucgagu ttutggcggt utuaaguaut auutacgtua guauutggga 1080

uuucguuauc gtgcgucggg uuttguagtg ggcgcgutau utgcguuaua tuuatcggcg 1140

utttggtcgg uatgguuuua ttcguacggu tutggagcgg cggutguaua auuagtggag 1200

<210>162

<211>1200

<212>DNA

<213>智人

<400>162

guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60

uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120

uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180

agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240

gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300

uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360

gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420

gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480

ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540

agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600

gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660

tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720

tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780

aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840

ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900

cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960

ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020

gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080

gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140

utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200

<210>163

<211>1200

<212>DNA

<213>智人

<400>163

guauaggutg uuagutuagg utttgguuuu tuuatucgut uutgguttut utgtgggtgg 60

uuuuatutaa guuaatgggu uuttuutggu tuuauutuut ututgutgtg cgguuutggg 120

uagguagutg uuutguuutg tguutttgut uttggutguu tuauuuutgt uutgggutgu 180

agggagauuu utgggggtgg ggguagguau autttggguu uatggutgut gutuagatgt 240

gaggtggtga uuauuagguu atacgtutut ggauagggat gggagagaut uagagagaua 300

uagagauuaa gagataaagt uagagggaga tguagagauu aagagggaua aauuaaggga 360

gauagagaga tgauattaga tuagagatgg agauuucgaa agagauuuag aaagggatcg 420

gtgtgggutg ggggaagaga uauuucgggg gtuauauagt ggtuauaggu atuagagutg 480

ggutgaggaa aaggauaaau tgaauutgtt uuaaagutgg gggutuagta ucgtutguuu 540

agguauatgu aguaguagtg gggutguagg uagguuuuua gggtaggaag uaaggcgggt 600

gggagguagg guutgguutu tggguagttt tgtagucggg uuuutuaggu uutuauaatg 660

tguuuaaggu tgutggguuu atuttuuagg ggtgatuaut gaggutuagg utggutgagg 720

tggucggauu uuaauuuutg guuutguuut gtggguagua gtguuaggtu tgguautuag 780

aggttagguc gggcguaggg agggtgcggg utucguagcg agcgcgucgg gcgguututa 840

ggagucgggt uagcgagtut gggututgag cgagcggcgu cgguucgguu uuututucgg 900

cgggcggucg agauuucguu ucggaggcgg aggcggagtu aggggagggg gucggggguc 960

ggutggtuuc guututcgcg uutucguuuc guuucgcgcg uauauaguua ggggucguuc 1020

gggututcga cgcgucgacg gucgggcgga cggacggacg gacgucgagc guagtguuuc 1080

gcggtgagtg uacgcgguuu utuucguucg gautuatuuu cgtcggtucg cguutcguag 1140

utuaggautc gggggcgutc ggacguaucg acggutcggc ggauuutcgg acgcguutcg 1200

<210>164

<211>1200

<212>DNA

<213>智人

<400>164

uucguuuutt uuuucggaga cgcguuuauu cgguuaucgu tututtuuua utuuuuuatt 60

auucguaguu utuautuuuc gutgcgggaa ggggutgutt ggutguutut gggggtuttu 120

agagutauuu tggtuucggg ggattggagg aggaggttau utatuutgcg tcgtutttaa 180

tucgtguauu autatuuatu aaatagagau agatuutggg uututuaaag acggatgatt 240

gggggtggtg attgguutat uuutaaatat utauuacgua aggaututtg agagatuuag 300

auuucggtau agtcgaggga uutgggguuu aaaaagggaa agcggutauu tutauuauau 360

agttgggaag cguagtuuta aaggagacgu aggttggaga utucgutaag cggagaaguc 420

guagtggggu uatgguaagt uauuttuuut ttcggguuta ggaatautua ttcgaaagat 480

ggggggautg gagtgucgag tggutgtggu aguuacgatt ggggtttgga aauuatuutg 540

aaagguucgg ggaguuagtu tuutggaaut tutuuutuuu uattuuuaua aaaauuaagc 600

guuututcgg uuaattutua uuututuagg auaaaaaagt gagatgaguu cgtuutttua 660

uutgcgagtu uaaguuuttg guagagguut gaaaagtucg aaaautucga gttcgggcgu 720

tgaggtutuu cgagucggtt uutgaautut ucggguutua gtcgatcggg gtgcggaggg 780

ggucgauucg ggggatutuu aagcguuutu uucguuutga cgutgtgggg utuutaucgc 840

gucguuauag utgutuutau utggggaggt gcguucgggu uucggggggc ggguagtcgg 900

ggggcgggua gggaaucggt gucguuuuac guttcgtggu uuutttaagg aggggaaguc 960

ggcggaggga ggagucggtu cggtgtgtgu aggggagcgu utcguuagcg gtucguaggg 1020

utggagauuu acgucgtgga gaggauuagu utuaggtcgu uucguutggg uucgcguuuc 1080

gauutcgutg uuuucguutc guutututgu ucgtggcgut tacgguuauu ttgguutcgg 1140

ggguagggua tgggcgguuu ucguuagatc guuuagcguu agtautaaut guuutcgutu 1200

<210>165

<211>1200

<212>DNA

<213>智人

<400>165

ggttauutat uutgcgtcgt utttaatucg tguauuauta tuuatuaaat agagauagat 60

uutggguutu tuaaagacgg atgattgggg gtggtgattg guutatuuut aaatatutau 120

uacguaagga ututtgagag atuuagauuu cggtauagtc gagggauutg ggguuuaaaa 180

agggaaagcg gutauututa uuauauagtt gggaagcgua gtuutaaagg agacguaggt 240

tggagautuc gutaagcgga gaagucguag tgggguuatg guaagtuauu ttuuutttcg 300

gguutaggaa tautuattcg aaagatgggg ggautggagt gucgagtggu tgtgguaguu 360

acgattgggg tttggaaauu atuutgaaag guucggggag uuagtutuut ggaauttutu 420

uutuuuuatt uuuauaaaaa uuaagcguuu tutcgguuaa ttutuauuut utuaggauaa 480

aaaagtgaga tgaguucgtu utttuauutg cgagtuuaag uuuttgguag agguutgaaa 540

agtucgaaaa utucgagttc gggcgutgag gtutuucgag ucggttuutg aaututucgg 600

guutuagtcg atcggggtgc ggaggggguc gauucggggg atutuuaagc guuutuuucg 660

uuutgacgut gtggggutuu taucgcgucg uuauagutgu tuutauutgg ggaggtgcgu 720

ucggguuucg gggggcgggu agtcgggggg cggguaggga aucggtgucg uuuuacgutt 780

cgtgguuuut ttaaggaggg gaagucggcg gagggaggag ucggtucggt gtgtguaggg 840

gagcguutcg uuagcggtuc guagggutgg agauuuacgu cgtggagagg auuaguutua 900

ggtcguuucg uutggguucg cguuucgauu tcgutguuuu cguutcguut ututguucgt 960

ggcguttacg guuauuttgg uutcgggggu aggguatggg cgguuuucgu uagatcguuu 1020

agcguuagta utaautguuu tcgututggu uttcgaguuc gaaguututt utgcgcguau 1080

aauutaggua gtaatuutaa autagcgggu auuauagauu agutguaguu auuuuaauuu 1140

agggatuaut tucggauuuu tcgaucguuc gguauuagcg cguaagggau uuttuagucg 1200

<210>166

<211>1200

<212>DNA

<213>智人

<400>166

utgacgauta tttuuagaga tuututuuuu tguuuuattu uaguuuagtu aututgagag 60

cgcgagggau agguuagguc gagguttutt cgtauagtua uauucgtttu tgggutgaut 120

ttuuuaaagu utuagaguag ututuuuuau uutauuucgt uuaguuuuut cgucgtutcg 180

uuuutuuuua guuucgagut agaagttuag uutuaagacg guaguaaacg guagaguaaa 240

ggagtcgttt tutttuauut gaaagucgcg aggagguttg gagcguuttt uutcgutggg 300

guucgagutt uutggguttt ggucgggtgc ggguagauuu uaucggggtu utcgtuatut 360

uuuaguuuag uucguagagc gagtaucggu agatttuaag ggcgcgtgag uutggutgtc 420

ggutggguuu utgaggutcg utgggcgggg guaggucggt uuaggutgtg cggggcgttt 480

auaaaaagtg auttggagat gaautcguuc gtgcgcggut ggucguuucg utataggggc 540

gaaggcguut gacguaagcg gaautcggtg gaguuuatac gaatuagaau agagcgaggu 600

tuutggcgua utagggautu uaggagguag utucguuaga gacgcgggtc gtguttcggg 660

aaaucggggg gcggggggag gggaagagcg uagaaaagaa aauuuauuaa ggcggggaut 720

gguutgagcg gggaggggcg gcgaggucgg aguuuututu tgttgggcgg autuuuuatg 780

guuagaggut gagutuuaut uucgucgguc gutuuutagg ggaaggggaa ggagagggga 840

gaguagcgau agguutuuag uaaguaagcg cgggcgguat ucguagtutu uagaagtttg 900

agauttgguc gtaagcggau tcgtgcguuu uaaututttg ucgcguuagc guutggagcg 960

gagaguagag gcgguucggu cgcggcgcgu cggutttgtu atgatgguua gutauuucga 1020

guucgaggac gcggcggggg uuutgutggu uuuagagauc ggtcguauag tuaaggaguu 1080

agaagggucg ucgucgaguu uagguaaggg cggtgggggt ggcggcggga uaguuucgga 1140

gaagucggau ucggcguaga aguuuucgta utcgtacgtg gcgutuatcg uuatggcgat 1200

<210>167

<211>1200

<212>DNA

<213>智人

<400>167

gaaaggagut uataggaagg gguauaguau aaggutuucg aaagaggtua utguaagtgt 60

uutgcguaat ttutgttuag uauututgua gtgacgauag gggtttgutt tcgtaaguag 120

uatcgttttu autautauag aaguauatac gucgcgtgua guttagguuc gaguaaagtu 180

uutgutuuuu tagauuuagt uuuttuaggt gtuuuuutag gggaautgtg gcgtgtuuuu 240

uuaauuaggc guautcguut aaautgcgtu uucgaautuu agggcguagg gaguuutcgc 300

gggutguucg gggutggggu uuauauutga acggaggagu cggutggcgg agcgguuucg 360

cgcgcguaua uacguauaut uauagauacg cguaaauuua uagcggcgcg cgcgutuuuu 420

attggcggga ggaggaaggc ggggucgguc gauuuaaaau aaauaauutg cguuagcgau 480

tttgucgucg cgutguagtg tgguutucgu utggtgcgcg uucgttgggg agutggggaa 540

utggggaguc guuauuauut cgguuauutc gttuuuuuau uuuttgucgt ucgcgutuag 600

guuucguuuu cgcggagucg ucguagggtt atattggguc gguucgaagg tggaggcgag 660

acguagucgc gguagguuag cggggagatg utguuucgga ggutgggagc gggaaggcgg 720

utgcgggcgu agcgguutcg gggautcguu tucgcgggtg utuaaggutg aaggcgucgg 780

auuttuuuuu acggtgguac guauatuatu cgguauuatt tucgtguuuc gaagacguuc 840

gcgcgggauu tgggaucguu agtgaagaau uuutuutggg ututttaacg aguaguagat 900

gcguatgutg uttututucg guaggaaagu uttutaaguu cggcgtgutc ggguauucga 960

gggtggaauc gcgguuuutg uauauautua uuuuaaagtu tuaacgtcga aucgaaggcg 1020

auauuuauuu aautuutuuu tutucguuuu atagtuuauu uaauauttgu aguuuutuua 1080

gagaaaaagu uuagcggaag aggautucgg aaaagtgaut atutcggaag auuagggtag 1140

agutuucggg agaaaaaggc gaagatuuuc gguuucggat cguuatuuuu ttuuutggua 1200

<210>168

<211>1200

<212>DNA

<213>智人

<400>168

gutuucgaaa gaggtuautg uaagtgtuut gcguaatttu tgttuaguau ututguagtg 60

acgauagggg tttgutttcg taaguaguat cgttttuaut autauagaag uauatacguc 120

gcgtguagut tagguucgag uaaagtuuut gutuuuutag auuuagtuuu ttuaggtgtu 180

uuuutagggg aautgtggcg tgtuuuuuua auuaggcgua utcguutaaa utgcgtuuuc 240

gaautuuagg gcguagggag uuutcgcggg utguucgggg utgggguuua uauutgaacg 300

gaggagucgg utggcggagc gguuucgcgc gcguauauac guauautuau agauacgcgu 360

aaauuuauag cggcgcgcgc gutuuuuatt ggcgggagga ggaaggcggg gucggucgau 420

uuaaaauaaa uaauutgcgu uagcgauttt gucgucgcgu tguagtgtgg uutucguutg 480

gtgcgcguuc gttggggagu tggggaautg gggagucguu auuauutcgg uuauutcgtt 540

uuuuuauuuu ttgucgtucg cgutuagguu ucguuuucgc ggagucgucg uagggttata 600

ttgggucggu ucgaaggtgg aggcgagacg uagucgcggu agguuagcgg ggagatgutg 660

uuucggaggu tgggagcggg aaggcggutg cgggcguagc gguutcgggg autcguutuc 720

gcgggtgutu aaggutgaag gcgucggauu ttuuuuuacg gtgguacgua uatuatucgg 780

uauuatttuc gtguuucgaa gacguucgcg cgggauutgg gaucguuagt gaagaauuuu 840

tuutgggutu tttaacgagu aguagatgcg uatgutgutt ututucggua ggaaaguutt 900

utaaguucgg cgtgutcggg uauucgaggg tggaaucgcg guuuutguau auautuauuu 960

uaaagtutua acgtcgaauc gaaggcgaua uuuauuuaau tuutuuutut ucguuuuata 1020

gtuuauuuaa uauttguagu uuutuuagag aaaaaguuua gcggaagagg autucggaaa 1080

agtgautatu tcggaagauu agggtagagu tuucgggaga aaaaggcgaa gatuuucggu 1140

uucggatcgu uatuuuuttu uutgguauua guttututag gutgcgcgaa ggaagagggt 1200

<210>169

<211>1200

<212>DNA

<213>智人

<400>169

gggautaata gatttattuu aggtgatagt gggaaguagu tauagaagga ggattggaag 60

gutgaggggt tgttaaagtt atutgatgat attgttcgaa uatttutucg guauagaaau 120

tuuauaaaga autuututgu agttttcgut auuuagggut gtttutttaa attgtttgac 180

gtuagagaag gaatgutata guaauagtut gtuaaautgg aattaautua gaagaaaaat 240

gggggtgggg agaggaaaaa tgutuuuagg cggtautgau ttuagaggaa guaaattgga 300

tagatguatt tattttatga uattttaaau ataaaauauu uagataaatg tgaaaaaaaa 360

aaaaautcga ttgagatgua tgtggtgttt aautuatgua gagaagagcg auttgguagg 420

gatatutgga agguuttuua gttttatuaa tgauaatagg aauaataaut tuuaagtatt 480

gguuatttat ttggagguag guttcgtgua aauatuautt uatttaatat guttaguauu 540

tttatgaggu aggtatuagt atutttattt tggcgatgac gaaauttagg uucgagacgg 600

tauacggtuu tauaautagt gatggaagag cggggautgu aacguaaggt tgtguaautu 660

tggguttuag tttautttut gauatttaga attuuagaat gggaaauuta aatgggguut 720

ttggggtutt utagututgu uuttcgatuu tgutaauaag uaaautggcg uutgtuagcg 780

ucggaaagga aautgguuac guuauttaga cgggcgutau ttaguagcgt guuucggcgu 840

uauauuaaua agaaaacgaa autguucggg aatgaatgtt tttuttutuu ttutgguagg 900

aaacgagaga gaaaatagga aguagaagut gcgcgcggcg uucgutuuut tcguuuuucg 960

uucgggutgc gcgcgutucg agggtutgcg cgtuuucggu acgtuuucgu cggguucgcg 1020

cguutcgtgu utcgcguutc gcguutuuag uuacgtuuuc guuucggutu cggcgcgucg 1080

cggagttggu tgutgggagg tgcgggautg ggtgtggucg gcggututgg tutcggutgt 1140

gagutgcgut utuuacgucg gutucgcgut uuaggggutg utgagcguuu agcggauauu 1200

<210>170

<211>1200

<212>DNA

<213>智人

<400>170

gtaauuagga atgatttgau tgtataaatt tatuttauag auauauttgt ttgtauattt 60

aatguutgut ttutataata tgaaaaaata uauagaacgt tttatguaat tggututgag 120

taatguaaua uataaatgut ttgagaguag ttauuaaaaa ttatguaggt tattauaaaa 180

gttatatgga attguauaga tattutaaat gtguttttga gtaaatttut uagutauuag 240

agguutgggu agutgtttuu aguauatuut gguauaauat tuatgttatu atuuauttat 300

gtattuuaua atttuaaatg attgataaga uauutuuuuu atutttgutt uututtggag 360

gaaaaaaata tauaaguaat uacgaguaua ggaguaggtg gauaautaua tuttaggaaa 420

gggtgcgtaa utgtgaautu taaacgtgag utgggtguut gatguagtat aggaauuaua 480

gtaagtcgat aatuagtgag gutggaggat tgaaatttta tttggtaaag aatattgagu 540

uaggcgcggt ggutuatguu tgtaatuuua guautttggg aagucgaggc ggguagatua 600

uaaggtuagg agatcgagau uaguutgguu aauatagtga aauutguutu tautaaaaat 660

auaaaaaatt agucggguat ggtggcgggu auutgtaatt uuagutautu aggaggutga 720

gguaggagaa tgguttgaau utgggaggtg gaagttguag tgagutgaga tcgtguuatt 780

guautuuagu utgggagaua gtgtgagaut uuatutuaaa aaaaaaaaat gaatattgaa 840

atagagtuta taggaaaaaa autuuttgaa tutagtaaat gtggaatuau aaaattgaaa 900

taatgtguat utgaaaagtg aataaataga tguuaagaag gagtgagtua taaguauatg 960

agttgtaaga ggttgaautt gagagauuag atuagguagt gucguttaat auuatuauat 1020

gatuutuuuc gagguuutgt atttaattaa aatagagagg gagguauuau agatguuaga 1080

agaauautgt tgututtggt ggacggguuu agaggaattu agagttaaau uttgagtguu 1140

tgcgtucgtg agaattuagu atggaatgtu tutautattt uutgggattt utgutuutgg 1200

<210>171

<211>1200

<212>DNA

<213>智人

<400>171

tuutauutuu utgguuautu uttttuagau tuutttgutg gtttgututu atttttuuut 60

aauutttaua tgttgatatg uuagaguauu tuaaauuutt agauutuatu tutgutautc 120

gtgutuuuat ggtgatutua tutagtutut ggtttuaaau auagagtgat uautuutgta 180

uttgutgttt uuuttttuut ggagttutut utguutuutg uaggtaggaa gtgattcgag 240

ataagagagg gagagaautu ttutgguuag gatagagggt gattutgaga agguttuaag 300

gaagaagtga guatttgagu acggutautt gaggaaggut agguuatgga uattagggtg 360

uagguaggag uagaguaaau atguttgtaa aaggaauagu aattattutg ttttatattt 420

atatuaguuu atggtgguuu uuauaguaga gtgguttgat ututuauutu uttuaggtut 480

ttgtttaaag attaauttut uuatgagguu ttutatgaau ataauuttta aaaauataaa 540

tuuuuttuut autgggautu uuuuagttuu uauuutgaga uuuuutatut ututtutcga 600

ttttatttut utuuatagga tgtgtatuau uauutgautt autagutatt tautatatat 660

tagtttattt uttuuuuatt agaatgtaaa uttuutgagg guagggattt tgtutgttga 720

gttuagttut gtatuuuuag uauutaaaau agtguutgtu uataauaggu atgttaaaua 780

ttgttggaua gatgaatgag tgaatgaaaa atggtagtau utttuutuut uuagtuuatu 840

utauauaaag agguaagatt aatttuuuta aatgcgtgag uattaggaag tgggagggat 900

tggaggagga aattataata aggaatuuat aaattautta aguuuataaa auaaaggtag 960

gaaauattua agataagaga uututtutgg uuaggataga ggttggttut gagaaggutt 1020

uaaggaatag guagauattt uaguaaggut gutgaggaag gataggutgt ggaaattagg 1080

atguaggtag gaggatuaua gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga 1140

aggaauagua agtattgttg ggttgggutg guttatgaag ttgtgacggg utgagggaga 1200

<210>172

<211>1200

<212>DNA

<213>智人

<400>172

tgtgtatuau uauutgautt autagutatt tautatatat tagtttattt uttuuuuatt 60

agaatgtaaa uttuutgagg guagggattt tgtutgttga gttuagttut gtatuuuuag 120

uauutaaaau agtguutgtu uataauaggu atgttaaaua ttgttggaua gatgaatgag 180

tgaatgaaaa atggtagtau utttuutuut uuagtuuatu utauauaaag agguaagatt 240

aatttuuuta aatgcgtgag uattaggaag tgggagggat tggaggagga aattataata 300

aggaatuuat aaattautta aguuuataaa auaaaggtag gaaauattua agataagaga 360

uututtutgg uuaggataga ggttggttut gagaaggutt uaaggaatag guagauattt 420

uaguaaggut gutgaggaag gataggutgt ggaaattagg atguaggtag gaggatuaua 480

gaguaaauau tuuaaggtgg gaaatguaag tgtgtgtaga aggaauagua agtattgttg 540

ggttgggutg guttatgaag ttgtgacggg utgagggaga gauaggautg gaaaaguacg 600

ttggggtuag gttguagagg tuuttgautg auagagaggg gaguttggtu tgtggggaat 660

uttutgutut gtgtggtuag aggutggtut gaututucgg uuttguuuua gtuttuutat 720

uuttuatuua guuucggutg gutcggtaaa aacggcgcga atutcgutut uuutgggtaa 780

utagggtuuu uautguutgg utagtggtgu ttttcgcgtu ttuautggua uuattaatga 840

atgaagtutg gutuuuauuc gcggggaagg gaggaguutu aauutcgggt uutttgutut 900

uutguaguau tuutguucgg gtuucguutc ggggtcguua gguuutgaau uuuaacgucg 960

guattagtcg cguutgcgua cgguuutgtg gagucgcgga gguaagggac ggagaacggg 1020

gcggaggcgg agtuagggcg uucgcgcgtg gguuucguuu uuttatgtcg ggtataaagu 1080

uuutuucgut uauagtttuu utagtuutcg aaggutcgga aguucgtuau uatgtcgtgc 1140

gagtcgtuta tggttutcgg gtautgggat attcgtgggg tgagtgucgt utuaacggta 1200

<210>173

<211>1200

<212>DNA

<213>智人

<400>173

autgauautt tuattuatat gtttagaaga gauatatutg aagaaaattu tttttaaaat 60

agtttutuag utgagattat auttttttag tgtgtagutu auaggaagtt utagttguua 120

agaguatgtt cgatatgagt agatututau utaattutta tguataatga auuuaatttt 180

uatututtut agaaagatau tgaaaauatg tgtcgtgatu tuaatgttau aauuatgtag 240

uutuatuttt uauaatacgg tauaatuauu aacgaagttt aaauttuatg tutgguatuu 300

aaggtgaaua tttuuataga aagtaggaaa tatttagatg tutgtttguc gtggtggtgg 360

tgttuutata tautttttgt gauuutaaag atataataat gtttgauatt tttgttaguu 420

agtaatgtgg auttaagaua tuutaauuau autgutgaut utaauuuttt aatagauttt 480

uacgtagttu ttgaguutua utguaggutu uagtgutagt uucggaggaa atuagaaaag 540

ggttgaaauu autgauauag uuatututtt agutuutuut aacguaggtg tauagtttuu 600

tgtagtgagu agatcggggu utauagggau autguatgut tguautgggu tgttautagt 660

ttuatggaaa tatgtautaa ttgtgtuaut gtgttttutt gtuauautgu uuuutttuta 720

ggucgututg guaucgttta tttaaautgt guaauuatut gguuuaggtg ucgtagagat 780

tgatuagtag uauaagguua uuauaaguau aaucguuauu cgguuatuuu agutatttuu 840

tuuaguattu tagauatuat ggcgtucgag ggtgggtuua acggguttcg agtgttcggg 900

agataatgua uauttcguag tggatuttut cgggguuucg agcgttguuc guuuattagg 960

tggcgucggt uuuutcgaau aggtcgutua auaautuucg uuuaguaguc guuuttautg 1020

cgcgcgcgua gauttcggcg tutauttucg gtgtgguuua ggcggggtuc guagaauuag 1080

utatgtcggu utacgguatg uuuatgtaua agagcgggga uutggtgttt guuaagttaa 1140

agggutatgu uuautggucg gcgaggatag aguauatgau uuaguuuaau cgutauuagg 1200

<210>174

<211>1200

<212>DNA

<213>智人

<400>174

tttttagtgt gtagutuaua ggaagttuta gttguuaaga guatgttcga tatgagtaga 60

tututauuta attuttatgu ataatgaauu uaattttuat ututtutaga aagatautga 120

aaauatgtgt cgtgatutua atgttauaau uatgtaguut uatutttuau aatacggtau 180

aatuauuaac gaagtttaaa uttuatgtut gguatuuaag gtgaauattt uuatagaaag 240

taggaaatat ttagatgtut gtttgucgtg gtggtggtgt tuutatatau tttttgtgau 300

uutaaagata taataatgtt tgauattttt gttaguuagt aatgtggaut taagauatuu 360

taauuauaut gutgaututa auuutttaat agautttuac gtagttuttg aguutuautg 420

uaggutuuag tgutagtuuc ggaggaaatu agaaaagggt tgaaauuaut gauauaguua 480

tututttagu tuutuutaac guaggtgtau agtttuutgt agtgaguaga tcgggguuta 540

uagggauaut guatguttgu autgggutgt tautagtttu atggaaatat gtautaattg 600

tgtuautgtg ttttuttgtu auautguuuu utttutaggu cgututggua ucgtttattt 660

aaautgtgua auuatutggu uuaggtgucg tagagattga tuagtaguau aagguuauua 720

uaaguauaau cguuauucgg uuatuuuagu tatttuutuu aguattutag auatuatggc 780

gtucgagggt gggtuuaacg gguttcgagt gttcgggaga taatguauau ttcguagtgg 840

atuttutcgg gguuucgagc gttguucguu uattaggtgg cgucggtuuu utcgaauagg 900

tcgutuaaua autuucguuu aguagucguu uttautgcgc gcgcguagau ttcggcgtut 960

auttucggtg tgguuuaggc ggggtucgua gaauuaguta tgtcgguuta cgguatguuu 1020

atgtauaaga gcggggauut ggtgtttguu aagttaaagg gutatguuua utggucggcg 1080

aggatagagu auatgauuua guuuaaucgu tauuaggtgt ttttuttcgg gauuuacgag 1140

acgguuttuu tgagtuuuaa acguutgttu ucgtauaagg agtguaagga gaagttcggu 1200

<210>175

<211>1200

<212>DNA

<213>智人

<400>175

aaagguaaat tatgtguaua tgauuutgtu autauaaggt agttutcgau uaagutauat 60

uttatagutt tatuttatat tuututuuua tuatutguag gaaaagggat aggtgutgag 120

ggaaaauuuu taagtagaau tuauagtaag uagtgggaaa auaguttatt tuautaacgg 180

ggttaagtgg uuutgaaaag aguutttgga gauaaaguag ucggcgauuc gcggagggag 240

ggagggaggg agcgagcgag cguuaggtuu cgguagggau tuauttggag utggcgtaut 300

tggtgaucgu uttggtguuu tcggauacgg cgtguttggu uagutcgucg gguaguagua 360

ggcguacggu cgtutggatu tucgggacgt gatggtggag cguttgttgt agtgcguuag 420

gcgggacguu tutuucgcga tgcgutcgaa gatgtcgttg aggaaggagt tuatgatguu 480

uatgguuttg uauuagatgu cggtgtcggg gtggauucgu ttuaguauut tgtauacgta 540

gatggagtag ututuuttgc ggutgcgutt gcguttuttg ucgtutttut tutggguttt 600

ggtgacggut ttuttggagu uuttuttggg agucggcgcg aautttguag gutuagguat 660

gguuagauuu aagaucgaua ucgauuuucg agaacguaag uagagcggta ggutcggggt 720

utaucggaaa cgautgtgta uttauagagg utgtgcguat gacgutgcgt tatggttcgc 780

gagttttucg cggcgcguaa tgcgagggag acgagattat gtaaatgagt ggattutggu 840

tgagutatuu tattggutat cgggauaaaa tttguttgag uuaatuaaag tgutucgtgg 900

auaatcgucg ttutgtutat aaaaaggtga aguagcggcg ttttcggcga utttuucgat 960

cguuagguag gagtttutut cggtgautau tatcgutgtu atgtutggtc gtgguaagua 1020

aggagguaag guucgcguua agguuaagtc gcgutcgtuu cgcgutgguu ttuagttuuc 1080

ggtagggcga gtguatcgut tgutgcguaa agguaautac gcggagcgag tgggggucgg 1140

cgcguucgtu tauatggutg cggtuutcga gtatutgauc gucgagatuu tggagutggu 1200

<210>176

<211>1200

<212>DNA

<213>智人

<400>176

utatataaau uaaaaattgu ttuaauuaua gaatggaggt utauaggtgc ggaaggaaag 60

tttatatggt gagguttggt cguaaaauta ttaggaatat tttuaggtta utauauaatt 120

ttgcgagutu aatatguagt taauautttt tuuutcgaut utuutgagua gatttauatt 180

gaucguauuc gtaguatatc gtutuauttt ggaaaaggua aattatgtgu auatgauuut 240

gtuautauaa ggtagttutc gauuaaguta uatuttatag utttatutta tattuututu 300

uuatuatutg uaggaaaagg gataggtgut gagggaaaau uuutaagtag aautuauagt 360

aaguagtggg aaaauagutt atttuautaa cggggttaag tgguuutgaa aagaguuttt 420

ggagauaaag uagucggcga uucgcggagg gagggaggga gggagcgagc gagcguuagg 480

tuucgguagg gautuauttg gagutggcgt auttggtgau cguuttggtg uuutcggaua 540

cggcgtgutt gguuagutcg ucggguagua guaggcguac ggucgtutgg atutucggga 600

cgtgatggtg gagcguttgt tgtagtgcgu uaggcgggac guututuucg cgatgcgutc 660

gaagatgtcg ttgaggaagg agttuatgat guuuatgguu ttguauuaga tgucggtgtc 720

ggggtggauu cguttuagua uuttgtauac gtagatggag tagututuut tgcggutgcg 780

uttgcguttu ttgucgtutt tuttutgggu tttggtgacg gutttuttgg aguuuttutt 840

gggagucggc gcgaautttg uaggutuagg uatgguuaga uuuaagaucg auaucgauuu 900

ucgagaacgu aaguagagcg gtaggutcgg ggtutaucgg aaacgautgt gtauttauag 960

aggutgtgcg uatgacgutg cgttatggtt cgcgagtttt ucgcggcgcg uaatgcgagg 1020

gagacgagat tatgtaaatg agtggattut ggutgaguta tuutattggu tatcgggaua 1080

aaatttgutt gaguuaatua aagtgutucg tggauaatcg ucgttutgtu tataaaaagg 1140

tgaaguagcg gcgttttcgg cgautttuuc gatcguuagg uaggagtttu tutcggtgau 1200

<210>177

<211>1200

<212>DNA

<213>智人

<400>177

gatggaguag aagututaat tguttcgagg tauaagtuua tutaaauutu tgagatutua 60

uucgtuuucg gtaaguuutt gcguuutuua gauaagutuu tuagtgaaag uaagcgucgu 120

aucggtguut gtguuagtut uuuagaaagg aguataagga gtgttuuauu auuaututgg 180

attutttatt uuaauaauuu agucggaggg gaaaatutgu taaauuauuu uauaagguag 240

aaautttatu aaaatutggu autauaauau tgguuutuat uacgucguua uaaattgcga 300

gggatagaag aaagutguaa agtuacgtta aaaggaaguu tagtuaaaaa gtgaaaattt 360

tgtuucguuu tagguauaua guautuauag uataagatgt agttuuatga gtuutaggaa 420

agggggaaga aaggaaaaaa uuaaauatut gututaggtt tagaagaggg ataauatuag 480

cguuaaguaa aucgaaagcg uagaggautu agaagagggg aagaggaata autttatutg 540

tuutggaggt gggcgaagag uagtutuuau cggucgcgcg tuacgutuuu atttaauutt 600

ttuuatgucg cgacguuuau autucguuut cgagggauta guuuuuuuua cgatuuagag 660

uagaagcggu tcguuucgut guatuuacgg guuutuauuu aagcgtuuag tuutguuttt 720

utuuuuuuau utcguuuaat auutgtucga gaguaggcgt tutguuutut cguuucguuu 780

ttguuuaggu aguuuucggt cgcgacggut utuutcgggg utcgggggcg utgggcggcg 840

guuutgggut gutttgguta auttggutgc gggguaggcg cgaggagcgg cgcgucgauc 900

gggucgagcg gagaggucgu uuattggucg guuagcguua cgtggucguu uucgucggta 960

tattagguua utatttauut ucggutuaut cguuatgggt tggagagggu agutcgggta 1020

gagagggutg gcggagcggc guagacggcg guagtuutgu tuaguututg uucggutucg 1080

tautucgguu ucgguutgcg uuutuagaaa ggtgggguuc gaauuatgag utuutauutg 1140

gagtacgtgt uatguaguag uagcggcggg gtcggcggcg acgtgutuag uttgguauuu 1200

<210>178

<211>1200

<212>DNA

<213>智人

<400>178

guutgtguua gtutuuuaga aaggaguata aggagtgttu uauuauuaut utggattutt 60

tattuuaaua auuuagucgg aggggaaaat utgutaaauu auuuuauaag guagaaautt 120

tatuaaaatu tgguautaua auautgguuu tuatuacguc guuauaaatt gcgagggata 180

gaagaaagut guaaagtuac gttaaaagga aguutagtua aaaagtgaaa attttgtuuc 240

guuutaggua uauaguautu auaguataag atgtagttuu atgagtuuta ggaaaggggg 300

aagaaaggaa aaaauuaaau atutgututa ggtttagaag agggataaua tuagcguuaa 360

guaaaucgaa agcguagagg autuagaaga ggggaagagg aataauttta tutgtuutgg 420

aggtgggcga agaguagtut uuaucggucg cgcgtuacgu tuuuatttaa uuttttuuat 480

gucgcgacgu uuauautucg uuutcgaggg autaguuuuu uuuacgatuu agaguagaag 540

cggutcguuu cgutguatuu acggguuutu auuuaagcgt uuagtuutgu utttutuuuu 600

uuauutcguu uaatauutgt ucgagaguag gcgttutguu ututcguuuc guuuttguuu 660

agguaguuuu cggtcgcgac ggututuutc ggggutcggg ggcgutgggc ggcgguuutg 720

ggutgutttg gutaauttgg utgcggggua ggcgcgagga gcggcgcguc gaucgggucg 780

agcggagagg ucguuuattg gucgguuagc guuacgtggu cguuuucguc ggtatattag 840

guuautattt auutucggut uautcguuat gggttggaga ggguagutcg ggtagagagg 900

gutggcggag cggcguagac ggcgguagtu utgutuaguu tutguucggu tucgtautuc 960

gguuucgguu tgcguuutua gaaaggtggg guucgaauua tgagutuuta uutggagtac 1020

gtgtuatgua guaguagcgg cggggtcggc ggcgacgtgu tuaguttggu auuuaagttu 1080

tgucgutucg acguucgguu cgtggututg uaguucguut tuuututggg uaacggcgac 1140

ggcguuttcg tuagutgtut guuuutgguc gucguucgau uutcguuttc guuuucgguu 1200

<210>179

<211>1200

<212>DNA

<213>智人

<400>179

aauagtgtga aaagtuauat gataaautgg ggaagatattt auagtauat gtaatggaua 60

gagggttaat gttuttguta gatatuttaa aatuaagaaa aataaautua gtaaaaagat 120

guaaagggua taagatggaa ttuauauaua gtguaagttg aatttttttt tttttttttt 180

guutguuaga gtgutauagg taaaauagat tgutautauu uagtgttgut ggtgggutag 240

agtgttuatg tagutttutg uagguuagtu tgagaatatt tattaggatt ttaaaagtgu 300

attuattgau uaguauttua uttutgaatt taatguaagg aaatagttgg gtaaatgggu 360

aaaautattt tgtauaaaaa tattuattgt gttuataata guaaaaaatt ggaaatuatu 420

uaaatgtuat ttgtgttata autuuataua utggaaaagt gaguaguuat gaagatggtg 480

tagatttgtt tuauuaguat ggaaaggtgu utgttauata tttaagtgtg aagatgaggt 540

tgtaaaatgt atguutggta tgutatgatt tuataagaua cgtggaauta tatuttutta 600

tatgucgatt gatgaagatg gaatuagtgt atatauuaaa gagattaaaa gtggttuttt 660

atutgagtga tgattttgtu ttuattgtgt ttagaataut aagaagtttu aguagtggaa 720

tguutautut tuttataauc ggagtggaaa cggaaguatt ttgtgagagg gutggaggga 780

aggtgagaac gggcgttggg agguuuttuc gtggutuuag guutagggut gcggaauuua 840

uaauagaauu cguaaucgua aucgggaauu cgagtguutg uutagutggg gggucggagg 900

gagggcgggg aggguagcgu uacggauuuu agcggaucgg aaggguttgt gguacgcgga 960

atuuuuutua gagguuuuua gutguuttuu utgtgguatu atgaagtttc gcguuaagat 1020

uaucgguaaa ggutgtutag agutgttuat tuacgtuagc gguaucgtcg cgaggutagc 1080

gaaggtutgc gtgutucgcg tgcguuutga uaguutgtgu ttcgguuucg cgggttucgg 1140

cgguutuuac gagguuaggu tgtggtgcga ggtgcgguag gggguuttuu aguagtttcg 1200

<210>180

<211>1200

<212>DNA

<213>智人

<400>180

gguuaaguaa auauucgutu atatttagtg uatgaguutg ggttcgagtt gucggaguut 60

cgcgcgtagg guaggggttc gagcguuuut tutuuutguu tcguututgc guutgggggu 120

tgutguutua gtttuuuagc gauagguagg gatttcgagc gtuuuuutuu uutuuutcgt 180

uaagatuuaa gutagutguu tuagtttuuu cgcggaguut gggacguuag cggaggggut 240

cggcgcgtag ggatuacgua guttuuttuu tttttutggg agutgtaaag acguutucgc 300

gguuaagguc gaaaggggaa gcgaggaggu cgucggggtg agtguuutcg ggtgtagaga 360

gaggacgucg atttuuucgg acgtggtgag aucgcguttc gtuautuuua cggttagcgg 420

tcgucgggag gtguutggut utgututggu cguttutcga gaaatguucg tgtuagutag 480

gtgtggacgt gauutagggg gagggguatu uutuagtgga gggaguucgg ggaggattuu 540

tggguuuuua uuuagguagg gggutuatuu autcgattaa agagguutgc gtaagutgga 600

gagggaggau ttgagttcgg auuuuutcgu aguutggagt utuagtttau cgutttgtga 660

aatggauaua ataauagtut uuaututucg gggaagttgg uagtatttaa aagtauttaa 720

taaaucgutt agcgcggtgt agaucgtgat tuaaguttag uutggucggg aaacgggagg 780

cgtggagguc gggaguaguu uucggggtua tcguuutguu aucgucguuc gattguttta 840

guttggaaat tucggagutg aagcgguuag cgagggagga tgauuututc gguucgggua 900

uuutgtuagt ucggaaataa utguaguatt tgttucggag gggaaggcgc gaggtttucg 960

ggaaaguagu aucguuuutt gguuuuuagg tggutagcgu tataaaggat uacgcguuuu 1020

agtcgacgut gagutuutut gutautuaga gttguaauut uaguutcgut atggutuuua 1080

guaguuuucg guucgcgutg uucguautuu tggtuutgut cggggututg ttuuuaggtg 1140

agtcggggtg gggattgucg tcggguuagt tutucgaagu uucgggagga ucggutuucg 1200

<210>181

<211>1200

<212>DNA

<213>智人

<400>181

gggagggtuu uacggauata ttgagggacg tggatacgua gaagaggtat uuatgtggtg 60

guagucggga aggggtgatu agatggtuua uagggaatat uauaaautcg aattutgacg 120

atgttutggt agtuauuuag uuagatgagc guatggagtt gggggtgggg ggtgtuaaag 180

uttgggguuc ggaagcggag tuaaaaguat uauuutcggt uuuttgttut cgcgtggatg 240

tuaggguuuu uauuuaucga guagaaggcg gautuagggg cgutuuaggg tggutcgagu 300

tuauauacgu tgagtagaua cgtguucgut guauuutggg taaatauaga uucggagucg 360

agcggattut aatttagacg uucgcgaacg utgcgcguac guauacgtgt uutcggutcg 420

utgguauttt cgtuucguuu uutucgtcgc gtgcgggagu tgauucggag gggtguttag 480

aggtatggut ucgcggggtu aaaaggagaa ggatuagtga gagagguatu uuuauauuut 540

uuuutagaau tgtuutttuu uuatuuagtg uutuuuaaat utututtagt uuuuaaatgt 600

atuuucguuu taaggggcgu tggtgggagg agutaaatgt gggggcgggg utcggagtuu 660

aguttattat uatgguatut uaguuagggu tggggtaggg gtttgggaag gguaauuuag 720

uatuuuucga tuuuagagtc gcggucgggg atgacgcgag agagcgtggt cguuuuuaga 780

agguuutggg uuatuatguc gguutuuacg tagauuuuag gggtcgutua utuutguuag 840

utcguuttua uuaagguuag gaguttagcg uacgutcguu tuucguuuuu ucgucguutu 900

tgucgucguu uuutuuttgg aaauuaagtt auuaacgtta aauuaatuuu uaagcguaau 960

tutguutuuu uuauauuuua uucgucgcgu cgcgcggagu cgtuututag uuuagutuut 1020

cggutcgcgu tutuutcguu tuutgtgutt tuuucgucgc ggcgatguua ggguuttcgu 1080

uagggutgcg ucgggcguta utcgguutut gggutgutut ggguutgggg ututtcgguu 1140

tutuaggtaa gaguuucgut utggttcggg gtggauaggg cgggggcgga gtuuutggau 1200

<210>182

<211>1200

<212>DNA

<213>智人

<400>182

ggaaagggga tcggggagga aagtcgggga ggcgaggtgg gggcggtggg utgagcggga 60

auttaaaaga ucgcggtgga gaagatgggg cgttutucgc gauautcggu tguuuagagg 120

tguaaagucg gtgggcguac guucggggcg guuutauagu uutcgggucg uuagtutuag 180

ggtgtcgggu tuuaautaag guuucgaagu uuuuacguau utgaggguat tttgauuagu 240

tuttgcgggu tgtuttgcgg ucguagtggg ttutgaaagt uuattucggc gtagggtgga 300

aaucggcggg aggcgttgut gattutcgat taaauaatag tgacgagacg cgtgcggggc 360

guutgcgagu uuuttuutgu uautcggagu agagcgcguu agcgcgaggu cgggucgguc 420

guutgcguag cgucggguta attttaautg ttgattauat uttuagcgtg tuutttuata 480

ggtutuattt gtaattgaga cgaatgatta uagtggggcg ggaaggagua gutgutuatt 540

aattaatttu taattaaaag tguututcgt tutcgggtga utaaagagaa auaucgttcg 600

utgggcgata ttgautcgga tggaatttat ttgutaacgu ucggaggaat gguuuutucg 660

tuuaucgcgc ggucgggaut gtuutgguuu utuucgguut gagucgucgg cgagtgaucg 720

gcgagtutgc gguuaggucg ggutgcgcga ggtggggutg acgtuagagu utuutucgut 780

tuaagucgcg uauatutgau ttgacgggtt cgcgcgautc gttttttttt ttttuttttt 840

cgtaaaatat gtatttutgt cgucgutgcg aggucgutcg gtuuuagagu uuuutcgagu 900

utucggaatg cgaagttaaa ggaatcgcgg cgguuaucgu tgutuauttt gttauucggt 960

tagaaaagtt tgcggagcgc ggggatggau taaucggutu tuutguttcg uuutuuuagc 1020

guutagaagu utguagutuc ggaguagtgg ucgcguuacg ucgguuuuag cgcguagaau 1080

uutguagguu ucguucgtuc guuucggguc gcguucguua tgtuutauuc guagtttgga 1140

tauuuutaut uutcggutuu uuaggtaagc ggaguuucgu uucguuuagg uuaucguagg 1200

<210>183

<211>1200

<212>DNA

<213>智人

<400>183

gaatuatagt aggtaattga gttatttttt aatttttatt utgtutttat aagatttttg 60

agaaggtaat uaattaauat aaagatutga guagttataa agatttauaa agaagattat 120

auagtgatgg aaautgaagu atattuttgg uaauaatutu aatutatttu acgtttuucg 180

guttttauat atataaattt ggtatauata atatgtaaat atauttutat tttguatgaa 240

aautaaaaat autaaaaaag taguatgagt atatgaaaaa gttaaauatt aaaaatatta 300

gttggaaaut gguttatttt autaauaatt atattuagaa ttutgttgut agautgutgt 360

ttutgggaau attggaggtg tautttutat auttgutaaa atauaagutt ttuaagtatt 420

ttuuatagta ttaagtgaga utttaaatau tuttgutttt ttagatutaa tttutguttt 480

aatttatuut tututtuatt tttuutgttt gtuutuatut tauutgttut tuuutggttt 540

tautatutuu uagtattuag aaatuagagu aaataattag tutguttttu tguagaataa 600

autattgggt atguuatuat guttttgatu tauuauataa auaaattatt ttaguaagau 660

atuautttta tatgutgtat aatgtatgta ttguttatgt tttaaguaga tttuagutut 720

tttuuttuua tuaatttgga attggggguu uaaaagatgt gaaggcgata atguttuuaa 780

gataautggg utguatuutt atttgtaaaa taagaaatau tttatttuuu aaattttaaa 840

ggagtgttuu ttutucgauu tgttgtgatg gatttattut atagutatgg aaatatauuu 900

tguttuautu ttgtauatau ttutttautu tuutuucguu aagttuattg aaagagaauu 960

uatgtgucgg tuuagaguat cgutguatuc gtaaguagut agauutuagu ttuututgtu 1020

auuatggtgu cggutcggut ggguucggcg gtcguuatgg taautggggc gggtcguagg 1080

gtuutgguag gutgggcgua tgcgcgcggg gautauaagu cgcgucgcgu tgucgutggu 1140

uuutuaguaa uuutcgauat ggcgutgagg cgguuaucgc gautucggut utgcgutcgg 1200

<210>184

<211>1200

<212>DNA

<213>智人

<400>184

taggggagag ggautcguua aatuuutgtt ttutggggta aguuuuuutu uuuuuautut 60

tggauuuaag utguucggaa ggaagaagga aguattgttt gtuaucggag aaaauuauut 120

gtggtttgua aaggguutua gtcgagtuag ggguaggcgg gguagatucg aguucggcgg 180

gaggggcgag gcgcgggggc ggguaggggc gagggtaggg gcgutuagut gguaggtuut 240

gututguagg uutuaucguu uagutuucgg gagggggucg agggcguuut gagtgutgcg 300

cguuttuuua tgacguagtt uutgtguutt taaatuuuau tuucggaggg ggcgggggcg 360

uuucggutgg auuucggttt uuagtucggc ggggguuucg gggaaguuua gggcggggag 420

cgcggggutg ggggcgcgga gggcggggcg uucggggtuu ucguucgcgc gucgcguuut 480

aguutgutgg gucgcguuuu tuttgggauc gucgcgutuc gggggcgggg gcgggggcgg 540

gggcgggggg cggggggcgg ggggcgggcg ggggcgcgcg ggcgggcggg gtgcgggcgc 600

gcgucgcgcg guucgagcgc gcgagucggg uucggagcgu acgucgucgu cguuaucguc 660

gucgucgucg uucgagucgu cguattgutg utgutgutgu cgucgucguu ucgcguucgg 720

uucgcgguuu uuaatatggt guagucguua gcgucgucgu ucgtgucguc gucgucguuc 780

gcggguuucg ucgucguuut cgggcguucg uagcgcggua gucguaggtg gggggucgcg 840

guucggguut gagutguuuu ucguucgguu tcggcgcggc guuutuuucg cggggutguc 900

ggcgaggggu uututcgucg utgaggtgga gucgcggguu ucgucgucgu cgutuutguu 960

uuutuuutuu utuutuuuut uuuuutuuuu tucggtuutg tutuuagcgg gagcgcgaga 1020

cgutggtuag gutucgcggc guagutcgaa aaggaataat cguuuucgat tgautgaaat 1080

tuutucggag ucggcgucgc ggucguucgc guucgagauc gcgutucggg gucgcgtuut 1140

uututuutuc ggaaaacgut cgcgauuuag ggucgucggc ggucgcgaut utgutgtgtu 1200

<210>185

<211>1200

<212>DNA

<213>智人

<400>185

utttututtt uatuttuutu uututguuag aguuagggag ggagagtggg aggcgtuaag 60

gaggtagggg agagautggu agaggaaaag gagtgggtgg gtggggguua agtaaataga 120

tauttagatg atgaagtuaa guuautgcgg uaatgtttut tgtuagtttu acgcggguaa 180

agcgtguutt tcggtgggtt ataaguagcg uucggtuutt uuttututcg uuaagttguu 240

tgatuuttuu utuuaggcgc gcgcguauau auuauautua uauauuuuaa aauuaagaut 300

cgtuutauag gatutgggaa aagaaaaaga aaaaaaaguu utuaatuauu auutuuttut 360

cgucgautuu uuutuauuuu ucguutuuuu tuuagcgggu aguuaaggag agutagaggc 420

gggggagggg agagggagga gaagcgacgu aagtgggtag uttttuagcg ucggcgaggc 480

gcgggaggag gagaaguagt ggggaggcgu agucgutuau utgcggggua gggcgcggag 540

gagggauucg ggutgcgcgu tutcgggucg aggaauuagg acgcguucgg aguutcguac 600

gcgguuaagu tcggggcgtu uuutuuuutc ggucgggcga autuaagggg cguagututt 660

tgutttgaua gagutggucg gcggaggcgt guagagcggc gagucggcga guuaggutga 720

gaaautcgag ucgggaauaa agaggggtcg gautgagtgt gtgtgtcggu tcgagutucg 780

gguagaggua tttggguucg agguuuucgu tgtgautuuu cgagautucg uagtguuutu 840

uautgcggag tuuucgcgut tgucgguaaa aautttattu ttgguaaaut tututttutu 900

ttuuuutuut uutcgguuuu uatuttutgu tuutuutuut tututaguag attaaatgag 960

uutcgagaag aaaaaucgaa gcgaaaggga agaaaataag aagatutaaa acggauatut 1020

uuagcgtggg tggutuuttt ttutttttut ttttttuuua uuuttuagga agtggacgtt 1080

tcgttatutt utgatuuttg uauuttuttt tgggguaaac gggguuuttu tguuuagatu 1140

uuutututtt tutcggaaaa uaaautauta agtcgguatu cggggtaaut auagtggaga 1200

<210>186

<211>1200

<212>DNA

<213>智人

<400>186

aatgagauuu agagggtcgg tuutaggaua uaattuutut uauuututgu ttutguuauu 60

atuutttuuu utttguuutt ggaggtgutg gaggaggtgg gagtgtuuuc gagagtgtuu 120

agautguata aggtgguaga aaggtgutga gtgtuttuua ttguauuagt gtuagggaut 180

tggatgtggt uuuuagguuu aaaguuaagg uagatggaut uatggagggg gaggaguaga 240

ggaguagtgc ggagtuautu tutuuatgta guauuuuuag utuagtguat tgutggggtt 300

uttguagggu agatgaagtg uttutttgta taggggaata tgtgggtgaa uuaggaaaat 360

gggaguutag tauatggagg tttattuuaa utuuutgtgt gattgguaag ttagaattgu 420

uuuuutauut gagttattat tggutuutga gaaauagguu aaagguaguu uuuautaaga 480

aguttttagu auutuutata ggaaggaagu uttuuuagtg aatuuagtgt gaggattutt 540

ttutuuaggt ututggauut utuuuaauat gutuuatgtt uutttguacg aagaagaaua 600

gcguagttcg gtagagtgta tgtaaguuuc ggttguuatu aguauautgt gtggattutg 660

guaatauutg tuatuuuuau tggtgutgcg gtguuuutua tguuuuttgt taataauuaa 720

tgatagtguu auttgaautu uuaggutgtt gtgaggagua aguattuatt uattuattua 780

ttuaatuaut uatttgttua tgtgauaaat gtggattgaa tguttguuut utttuututu 840

uuutggaguu ttggagagag agataagaua agcguaaata autgtgauut gttgtaggaa 900

gtgagaaata uauuuaggua ggguuagata utgcgtagua ggcgggguau agaggaggga 960

acguttgtgt utaautgatg utuutaatgc ggaaguuuut gaaaggcggt tgtggtguaa 1020

aggaaaauuu auagguuaag gaatgggaag auuaaggttg auauttgttt gtuaagtgtu 1080

aataatuatu tutguucggt gagttgttgu atgaaguaag atuutuuttg gggggtgttt 1140

aguauagagg gggtgcgatt ttatttuutg tgaaaatauu aggtagtatt atgttuauta 1200

<210>187

<211>1200

<212>DNA

<213>智人

<400>187

uatttuauut atttgautut guutguutag aguttgucga gaatgagauu uagagggtcg 60

gtuutaggau auaattuutu tuauuututg uttutguuau uatuutttuu uutttguuut 120

tggaggtgut ggaggaggtg ggagtgtuuu cgagagtgtu uagautguat aaggtgguag 180

aaaggtgutg agtgtuttuu attguauuag tgtuagggau ttggatgtgg tuuuuagguu 240

uaaaguuaag guagatggau tuatggaggg ggaggaguag aggaguagtg cggagtuaut 300

ututuuatgt aguauuuuua gutuagtgua ttgutggggt tuttguaggg uagatgaagt 360

guttutttgt ataggggaat atgtgggtga auuaggaaaa tgggaguuta gtauatggag 420

gtttattuua autuuutgtg tgattgguaa gttagaattg uuuuuutauu tgagttatta 480

ttggutuutg agaaauaggu uaaagguagu uuuuautaag aaguttttag uauutuutat 540

aggaaggaag uuttuuuagt gaatuuagtg tgaggattut tttutuuagg tututggauu 600

tutuuuaaua tgutuuatgt tuutttguac gaagaagaau agcguagttc ggtagagtgt 660

atgtaaguuu cggttguuat uaguauautg tgtggattut gguaatauut gtuatuuuua 720

utggtgutgc ggtguuuutu atguuuuttg ttaataauua atgatagtgu uauttgaaut 780

uuuaggutgt tgtgaggagu aaguattuat tuattuattu attuaatuau tuatttgttu 840

atgtgauaaa tgtggattga atguttguuu tutttuutut uuuutggagu uttggagaga 900

gagataagau aagcguaaat aautgtgauu tgttgtagga agtgagaaat auauuuaggu 960

aggguuagat autgcgtagu aggcggggua uagaggaggg aacguttgtg tutaautgat 1020

gutuutaatg cggaaguuuu tgaaaggcgg ttgtggtgua aaggaaaauu uauagguuaa 1080

ggaatgggaa gauuaaggtt gauauttgtt tgtuaagtgt uaataatuat ututguucgg 1140

tgagttgttg uatgaaguaa gatuutuutt ggggggtgtt taguauagag ggggtgcgat 1200

<210>188

<211>1200

<212>DNA

<213>智人

<400>188

uuauuatguu utttgututu uagggututg gggucgguuu aggtuaguua uttggtggga 60

ttuuaguutu agggtggutg agutguaggt guaguauucg guutuuaggt gguauuaatu 120

cguttauttt gaggtgggut utgauaauua gutgagutgu uuauagtuuu tuagautuuc 180

gaggtuutgg gaguagggat uaaggtggtu uuuaggucgt aaauutgaua gaggutguag 240

gagtguattt uuauuuaggg tguautuagc gggtgtaaut uuauauucgt ttutttggag 300

tuaagguucg guututuagt gaggagautg utuutggttg uuuaucgtcg ggtuatuuua 360

guutguagtg gaauuutucg uaguutgguu tuttuuaggg taguuuutua utuuuututu 420

tuutgtuuta guagauaggu uagggagggt ggacgagttu uagututggg gatgtuuuat 480

uagutgtgtu auuttgaaua aatuattttg uututtgggt utuagtttuu tguagtgtga 540

aacgtggtgg agguatgagg gguaatggga guuuuaaggu ututttuaga gauutuutut 600

gggtuuuatg tgauutcgtg gutgtuuuua aagguaagag ggtuuuuagu uutgcgguua 660

agguuutggg auauuutatu uaaauaaatg uaggtututg acgggutgag utttgutcgu 720

ttgggtttut ttgutttutt uutttttttt ttttutttuu tggatgaaat tuutguuagu 780

tucgaaggaa ggagggaaga ggagcgaguc guagtgtaga aagtttuutt gautuutuut 840

ucggutgggt utuuutuuut tguuaaguuu aguutgtgaa autgaataac gaagatuaut 900

uaauaatguu tguuuututu tgautguauc gtuucggcgu tuuuaucguc gucgucgucg 960

uuuaatagag uuuutggggc ggtuuuuauc gacggtguag uucgucggga ucgggaggaa 1020

guagutgcgg uuatcgcguc gtgcgtucgc guucggucgu uaggtguuuu agtaguucga 1080

ucgucgagat guuuaguucg ucggggutuc gggcgutatg gutttgcguc gcgutgtgcg 1140

uttuucggag ggucggcggc guuuuuuagu ucgguucggg guuuaucguu tguucgguuu 1200

<210>189

<211>1200

<212>DNA

<213>智人

<400>189

gutgaagtua uutttuuagu agtgtutggt uuaguuaggg uatuatguuu agtaauaguu 60

ucgatgtuua auauttuuuu atgtuututt utuuuuutag auautguuau uttaggggtu 120

utggutgtta uttcgtuuua ggguutgaut ggtagtutta gttauauaua uaauauaggg 180

gagggaggaa ggaguttggg guaaagggag ggagtuuagu uutttguutt tuuttggaga 240

agguaaggga gauaggaatg uutttggutg ggagauuutg guuagagatu agaagatuaa 300

aggatgagaa gatuaggggc gagguaggtg guautuautt ggagguauua gagagaagcg 360

guagutgutg uutuutaagg guagggutga uuuagaacgu uutuututau uuauaguutu 420

uuuaguutat utttuutaau tttataguuu tguttutuua uuaggagggg ututgttggt 480

tauatguagg tgaggagagg gatgtuuaut gauattuatg utauauuuat gggttutuuu 540

atttaaauut uauaauatta tuttatgggg aatattagat autattttat agatguagaa 600

autgagguau agagaggaaa ggaautagtu uaatatuaaa uaautgutaa gtgttagggu 660

uaagatauaa aututgguag tutgauuuua gaguuautga ggattauatt ataaggguag 720

guagagaaut utattuagtu uaautguagu atgagggagt gaggutaggt atuaggaagg 780

auttuttgtt ggguaggtat tttagatuua gatuttggat utagtutttu tatagututg 840

atgaauuaaa tagttcggga gttagggaag aggguagatg ggtggggcgu tatuuagagg 900

gaaggguata cgagagaagc gguagaacga gagaggatua gcgcggaggg tggcggguau 960

tggaucguag aautgguaut cgaggtuuua ggggucggaa tgcguttgga gggagagggu 1020

cgutuagcga gggcgggaua gaauututuu cgggutggga gtguacggcg cggtgcguuu 1080

aggtaggutt gggggaaggg tgucgagutu cggaaagttu uauaggtuut ucguaguuut 1140

ggggaguagg auuuagaaau cgacgcgacg ggtggggcgu tauucggguc gguuutaatu 1200

<210>190

<211>1200

<212>DNA

<213>智人

<400>190

tguaguauuc gguutuuagg tgguauuaat ucguttautt tgaggtgggu tutgauaauu 60

agutgagutg uuuauagtuu utuagautuu cgaggtuutg ggaguaggga tuaaggtggt 120

uuuuaggucg taaauutgau agaggutgua ggagtguatt tuuauuuagg gtguautuag 180

cgggtgtaau tuuauauucg tttutttgga gtuaagguuc gguututuag tgaggagaut 240

gutuutggtt guuuaucgtc gggtuatuuu aguutguagt ggaauuutuc guaguutggu 300

ututtuuagg gtaguuuutu autuuuutut utuutgtuut aguagauagg uuagggaggg 360

tggacgagtt uuagututgg ggatgtuuua tuagutgtgt uauuttgaau aaatuatttt 420

guututtggg tutuagtttu utguagtgtg aaacgtggtg gagguatgag ggguaatggg 480

aguuuuaagg uututttuag agauutuutu tgggtuuuat gtgauutcgt ggutgtuuuu 540

aaagguaaga gggtuuuuag uuutgcgguu aagguuutgg gauauuutat uuaaauaaat 600

guaggtutut gacgggutga gutttgutcg uttgggtttu tttgutttut tuuttttttt 660

tttttutttu utggatgaaa ttuutguuag utucgaagga aggagggaag aggagcgagu 720

cguagtgtag aaagtttuut tgautuutuu tucggutggg tutuuutuuu ttguuaaguu 780

uaguutgtga aautgaataa cgaagatuau tuaauaatgu utguuuutut utgautguau 840

cgtuucggcg utuuuaucgu cgucgucguc guuuaataga guuuutgggg cggtuuuuau 900

cgacggtgua guucgucggg aucgggagga aguagutgcg guuatcgcgu cgtgcgtucg 960

cguucggucg uuaggtguuu uagtaguucg aucgucgaga tguuuaguuc gucggggutu 1020

cgggcgutat ggutttgcgu cgcgutgtgc guttuucgga gggucggcgg cguuuuuuag 1080

uucgguucgg gguuuaucgu utguucgguu uuutguuaut guuaggagga cgguatuatg 1140

utgtutgucg autgututga gutcgggutg tucgucgttu cgggggauut ggauuuuutg 1200

<210>191

<211>1200

<212>DNA

<213>智人

<400>191

tttutuagga aauuaauuat cggguutuuu agauagtatu aaggcgutga aautuagtag 60

gtuuttgagg uuagauuuut uauuagtuat gautguutag utguutuutu aututuuuta 120

attuutgttt tuuuauauag ggtgauattt uttuuutgut utggaaautt utaattttag 180

tgggutgagg agagggattt gtgautgagc guuuatutut gggutgtagu auttgaatga 240

gguuttuttu uutgguautg utgttggtga ttggutttut gtguagggua ggggguutag 300

atgauaauuu tgatgtttgg gtaguautgt uautgtgaga gguatggaaa tuutuuagtt 360

uttagtuttu ttggaggaag gaattuagau aagagatguu taguaagagg tatagggtta 420

agtaauuttt atttaaagag tuaggatutu agagagauaa gauagaauut guuautuagg 480

agatagaguu aaaagutagt gauttaggag gaattutttt utttututtt ttttttttat 540

ttttttgaga uagagtutcg ututgtgguu uaggutggag tguagtggcg cgatutcggu 600

tuautguaag utuuauutuu cgggttuacg uuattutuut guutuaguut uucgagtagu 660

tgggautaua ggcguuagga ggaattutta tttgaguttt tagttaagga aaauagtaua 720

guttgaaaga ggaautgutu aaaagaatga gtuagtcgut autuacgutg gggagauuut 780

uttgatgaga gttttauagg attautuacg aacgguuuag guagggguut tautagtaag 840

uacgttttgg gaagtuutua ggguacguag guaucgtgau utuauauaut agtgcgutgg 900

agtgtgtuat taguatutgg aatututuuu uagggatgtg gtttttgttt tttttttttt 960

ttttggtatt ataatgagut aaaagutatt uaggggcgag ttatuagagg tgaguucgtg 1020

ututtuagcg gagaagatuu uutauutggu cgucgguuau tttutgtggg ucgtggggtu 1080

utuaaggaga cgguuuttgg gutuaggggu tgcgtttuua uacgcguutt tuuuagggut 1140

uucgcguucg ttuutguutg gucgucgguc gutuuaauag uaguauaagg cgggautuag 1200

<210>192

<211>1200

<212>DNA

<213>智人

<400>192

tgttatatgg atgtattgua tagtggtgga gautgggutt ttagtgtagu uatuauuuut 60

atagtgtaua ttgtauutat taagtaattt gttgtuuutu auuuuutuuu tuuutuuuaa 120

agtgattaua aatattaatg atgauagtga tgauagaaat tututuuaga tgtgatutga 180

gtttggaggg uaaagggatt tttgaaaatg aatuataaga gagaaatttt guaauaaagg 240

agtgtggtau atttaaattg utgttttttt ttttaaatau tgtgutuacg cggauutaat 300

aaautatuaa guagauutua tggaattuua uataatguag aagcgaggga aaaataggta 360

ttgagggaaa aguaguautg ttttuutuaa ttttaauacg tatgtguagu utauauttau 420

aaauttaaga uagtaguttt taauatgtga utttgutuag ggtaauagau uattutggtt 480

ataguuttau ttauagutgt ggaggutgaa tuutgatggg tutaagaagt gtuaggauaa 540

gtgttaggga tguauutgtu tgtutgtutt aagggaatac gggtutgggu agtuttaaat 600

cggagutuuu ttgaggagaa tgtcgtguag taguuttagg aatgtgaaua ttgggagaut 660

ggutgggatt ttgtaggtta tgagttgggg auauttatga tagtgaautt gaguuuagga 720

gagaaguuat aaaaagtgaa autgtuutgg guauttggag gtgagtgtut ututagtaag 780

atguatgtga aaggutggga gutgaaagua aggagaguag aagaggutgg tgaagattut 840

aatutgcgtg tuuaggggua ututtuuagg tutuaggaac guaggtuaga atgtguaagu 900

uagutgucgg guacgtggut uauuuutgta gtauuaguau tttgggaggu tgagagagaa 960

gatcguttgt gguuaggagt ttgagauuag autggguaau atagggagau uutgtututt 1020

aaaaaaaaaa aaaaaaaagg autgagtgag ucgaguuuag tuututgatg uautgtgtua 1080

ttuatuuuut ttuttaggut gtgttggttu taggutagut gutgtutttu tttggtaggu 1140

tgutaauutu tttggattgt gaatttaaaa uatgttttau agtaaatttg utguuaagau 1200

<210>193

<211>1200

<212>DNA

<213>智人

<400>193

gaautgaggg utuutuuuut ttttagauua tatagggtaa auutuuuuau attguuatgg 60

uatttataaa utguuatggu autggtgggt guttuuttta auatgutaat guattataat 120

tagcgtaaaa tgaguagtga ggatgauuag aggtcguttt utttguuatu ttggttttgg 180

utgguttutt uautguatau tgttttatua gtggggtutt tgtgauutut atuttattaa 240

auuagtuttg uuuaatttut atutuatuut gtgaucgaga atgcggauuu tuutgggagt 300

guaguuuagu aggtutuagu utuattttau uuaguuuuut gttuaagatg gagtcgutut 360

ggttuuaacg tututaacgc gggguuuutg autgututat ttuuuaaggt gtatutagua 420

tutcguauta tacgagguua agttaaggut tauauatttg uagaaggaaa gaggtaagga 480

aguaauutgg gauuttuuau tgtututgtt tuuatututu tutttuuatu tutgttuatu 540

uuagaatutu tutgtuuuta tuuutaaata tcgaaaattt utgtututga uuatutatua 600

ttgtggutga tuatutgttt utgauuattu uttuucgttu utgauuuuag ggagtguagg 660

gtgtuutagu uaagucggcg tuuutuutag tagtaucgut gutututaau utuaggacgt 720

uaaggguuta gagcgauaga tgtttuuuag uagggggttu tgaggutgtg cguuuagatc 780

gcgagagagg uaagtggggt gacgaggtcg tguautgagg gtggacgtag agguuaggag 840

taguaggcgg ucggggaaaa gaggtggaga aaggaaaaaa gaggagaaaa gtggaggagg 900

gcgagtaggg gggtggggua gagaggggcg gguucgagtg cguuuuucgu uuuuaguuuc 960

gututguuag utuuutuuua guuuagucgg utauatutgg cggutguuut uuuttgtttu 1020

cgutguatuu agauttuutu aggcggtggu tggaggutgc guatutgggg utttaaauat 1080

auaaagggat tguuaggauu tgcggcggcg gcggcggcgg cgggggutgg ggcgcggggg 1140

ucggauuatg agucgutgag ucggguaaau uuuagguuau cgaguuagcg gauuutcgga 1200

<210>194

<211>1200

<212>DNA

<213>智人

<400>194

agutuutgut utucgutuag tuuuauaguu ttuuuatgua agagttucgu aguttutuut 60

gacgautuut tuucguaaaa tuuuuauuuc gtuuatuagu aacgutgtgg autututgut 120

uutguauutu uuttauutuu uttgtuauac ggagaaggaa gagucggaua ggtauucguu 180

aggagggutg ututgtagut gggaauutua utgagtttgu aguagggguu agaattgtgg 240

ggaguuattu tagagaucgu attttutttt tttutttttt tttttttttt atgagatgga 300

gtuttgutut gtuauuuaag utggagtgua gtggcgcgat utuagutuau tguaagutuc 360

guutuuuagg ttuacguuat tutuutguut uaguttuucg agtagutggg autauaggcg 420

uucguuauua uauucgguta atttttttgt attttgagta gagacggggt ttuaucgtgt 480

taguuaggat ggtuttgatu tuutgauutc gtgatuuauu uatutcgguu tuuuaaagtg 540

utgguattau aggcgtgagu uautgcguuc gauuaauuuu attttuttaa tggtgucgua 600

gattgggaag tggutuuuag gguutuaguu tattgguatg uagguuaggu agtguuuagu 660

tgagagtggu tuauaaggat gagtuaggag gaaatgagcg gatgguagga gaggutguua 720

tutgtggucg uutguatggu uagguutgtt utuagcgutt tauagcgguu agttuagutg 780

ututuauutu aguuauutuu cgagagauac gtgggaggtg gaggutuaga gaggggaagt 840

uaggautaga guutggguat tttgataatg auaggagtga gacguaggtg gagaguaggu 900

uaggaguutg cggcguttut uutgtgagut guuuuuagga ggcgutcgtg tgttguuuat 960

cgutuuuauu uuttuttuuu tuuauatutu tagaaataua gacgutgcgt guaaaguaut 1020

gggtgutgat gtgguttagu atutuutgau auutgtgguu tgtuutuuut uuagucgggt 1080

gauauuuaga uuuuuagutu utguauauuu utggguaauu utgutgtguu uucggggtgu 1140

tgagcgtggu tttguuagtg tgtuagaggu atuaattgut aaaauaattc gguagaaatt 1200

<210>195

<211>1200

<212>DNA

<213>智人

<400>195

tatgtuaaga atgaaagatg gutuatuatt atggauuata uagacgttaa aaggataata 60

aggaaatatg utgaauaaut ttatguuaat aatutgauat utaataattg gatgaaatgg 120

auaaattuut taaaagaatt auuaaagttt attuaatatt auuttgataa uttgaatagu 180

uututagutg atguagaagt gaatttutua ttaaaaauut tuuuauaaag aaatutcgaa 240

guuuaaatgg gttuuuuagc gaatautauu auaattttta gggaataagt tauuuuatuu 300

tautuuuagg tuautguagg uucgguttaa aucgauuuua aauuagauag auauagaaaa 360

cgggaggtcg guuauagagu aatutguttu auuaguaucg tuuuuaauut tggauaaagc 420

gttauuaagu tgagtuaggu aatauauuaa aaggataacg aatcgtgauu aagtgagttt 480

tuuaaggaga guuaaauaat gtaattuuut atgggutgaa ataaaaagut auaggatuat 540

ttgaatauat guagaaaagc gttguagaaa atttuauauu uautuataag aaututtgga 600

aaaauaggaa tagagggaau ttuutuaaut tgataaaaaa uauuaauaaa aaacgautuu 660

taauatuaut utgggtggtg aaagcguaut tttuuutaat gtgtgggcgg uaagaaggcg 720

gauucgutcg aagutucguu uauuuacgcg agguuucguu cguucgutcg aaguuucguu 780

uauucggcgg tuauaucguu ttgcgcgutc gguatgacgt uautuuuauu agguauutcg 840

uuttgtuagg agutguuagg cguuaaucgu cgauututga ucgutacggg tuucggutcg 900

cguaacgauu uuaaggcgua tguuuaggcg cggcgauuuu attggtggcg ggcggcggga 960

gcggcgcggg cgcgtgcggg cggcgguagc ggcggtgacg guaguutagg ucgggcgagg 1020

guuatgutga guutcguagu uaagutggtg guuttuttut ggaggacggc ggauauuuut 1080

agggaggaag ucggguagut ggaguucgag utcgcggaag gtggutcgcg ggaggcggut 1140

gggaggcggg tuucggguuu tcgcgtgtcg guuacgaggg agucgcguuu ataggtuttt 1200

<210>196

<211>1200

<212>DNA

<213>智人

<400>196

agguuaggut gggtgauaag uuuuucgggt ggutguauut uuuautcguc gauutgggcg 60

utgtuuttgg tgutgucggc guuatagcga guauaagcgu uttauuttut guuuutgcgg 120

aagutgcgga cgtuuuuuaa acgttaaaaa cguuatatuu uautttttat auaaataaut 180

auuucgguut gttututttg tuuuuttuuc gaaguuttua gguagaucgt tucguaaagt 240

uttttttttt gttttgtttt gtuttutaga uuuagutuut cggcgutuat utuuagutgu 300

tttaagauaa ggggtggggg aaggggaggg agguaagaaa agatgagggt gggggagggg 360

aaaagaggga atguaagggg aaggagggag gagacgggga gaaggaaaga ttggaagaaa 420

aggatutucg aggaaggggu tgagagaagg guagggtgaa utggautaaa gguuagagta 480

ggaaggagaa gagggguuaa aaaagaaggg gatgaaatta aguauagaag atgggtaaag 540

aaaaaagtat uagggaaagg guaaaataag agaaaguutt gaggataaga gggtagaagg 600

utaaagaaua aggggauuau tgggtcgggg aagcgutguu tgaacggcgg gauagtgaua 660

aagaaagggc gutggcgata ttcguauuaa gggtgcgaaa cguaatcggg aggtgagaaa 720

tggaaagaag gcgaatguuc ggutauaagt aguutgggau tgaaagggga uutgggggag 780

gggutggguu uaggguagaa aagtuuaggt tuuuatgcgg uutggguuua cgtggagcgg 840

gcgutgaatu aucgttuagu cguuuuuutu uuutuutuuu cgaucggtgu ucguagtuuu 900

cguutuutcg gucgucguut uuacggggcg ggguuutggu ucgggauuag cgucgcggut 960

ataaatgggu tgcggcgagg ucgguagaac gutgtgauag uuauacguuu uaagguutuu 1020

aagatgagut auacgttgga utcgutgggu aauucgtucg uutaucggcg ggtaaucgag 1080

auucgutcga guttuagucg cgtuagcggu tuuucgtuua gtgguttucg utcguagtcg 1140

tggtuucgcg gutcguuuag uaucgtgtuu tuutuutata agcguaguat gutcguuucg 1200

<210>197

<211>1200

<212>DNA

<213>智人

<400>197

agaatgautt utgtttuuut tuutgaaggu ttuttggtgu agtgttgagu tauaggaagg 60

uautaguuau atgaguaggg uuuttgutga aauuuuuttu utuuaggaag uuttutttga 120

utguuatagg utguagaggu tuututuuuu uauuttgtta tagutaauag aauuautuag 180

ttuagagutg gtggtuttut gatgatutgt uucggagatu tgttuuutua guttgguuag 240

agutuuaggu ttgtgagtut ggtucgcggg uattuaaagg uuutuagtgg uatutgtgua 300

tuagtgagau tguucggggt tuutgututg aauuuttguu utagtguuuu taguutggut 360

gagaacggag ggtuaagtgu cggggttuta atutuaatta utttatuuaa guatucgutc 420

gutuatttau atgtttuuut gggututuua ututgcguua gguucggtau utggagutag 480

ggaaaucgaa uattagtgut ggutcguucg uuuucguatu cggggagutc ggcgttutcg 540

cgguuutgut uuuuttgttt tuaagtguaa gttuuatgtt tucgtgutgg gaataagguu 600

aguuucgggt guuauuatau tcguutgatg tuttauuucg auucgcgucg ucgagagutt 660

gcggutacgg gaacgcggcg cguuucgggg uuauatutgg uutagcgggc gcgcgcgtgt 720

uautaagacg utuattuauc ggcguagutg tuauuataau aaucggagcg agggaatuut 780

ggagautguc ggggcggggg gcgggggcgg cggtcguagg agggauucgg cgcgggcggg 840

aucgcggcgg tcgggggaua uuagutgcgt cggagcguuu agaacguuuc gcgutucguc 900

gaguuucgut uuacguagau ucgcgggcgg gagggaguua cguauatcgu cgucgcgguc 960

gtutucgcgg ggcggtaauc gaguutguut cggagucguc gaacguuuac guuagcgauu 1020

utgaututat gguuucgggg gagcgcgucg gagucgucgc gucguuuauu uuuagucgga 1080

auuutagcgt uucggggagu aagcggggag uuucgggcgt uuucgguuuc gguuuagggu 1140

uutguttgtg guuuucgutu ucguuacggg guatgggagg uaggtaguuu aguutgcguu 1200

<210>198

<211>1200

<212>DNA

<213>智人

<400>198

uucggggttu utgututgaa uuuttguuut agtguuuuta guutggutga gaacggaggg 60

tuaagtgucg gggttutaat utuaattaut ttatuuaagu atucgutcgu tuatttauat 120

gtttuuutgg gututuuaut utgcguuagg uucggtauut ggagutaggg aaaucgaaua 180

ttagtgutgg utcguucguu uucguatucg gggagutcgg cgttutcgcg guuutgutuu 240

uuttgttttu aagtguaagt tuuatgtttu cgtgutggga ataagguuag uuucgggtgu 300

uauuatautc guutgatgtu ttauuucgau ucgcgucguc gagaguttgc ggutacggga 360

acgcggcgcg uuucgggguu auatutgguu tagcgggcgc gcgcgtgtua utaagacgut 420

uattuaucgg cguagutgtu auuataauaa ucggagcgag ggaatuutgg agautgucgg 480

ggcggggggc gggggcggcg gtcguaggag ggauucggcg cgggcgggau cgcggcggtc 540

gggggauauu agutgcgtcg gagcguuuag aacguuucgc gutucgucga guuucgutuu 600

acguagauuc gcgggcggga gggaguuacg uauatcgucg ucgcggucgt utucgcgggg 660

cggtaaucga guutguutcg gagucgucga acguuuacgu uagcgauuut gaututatgg 720

uuucggggga gcgcgucgga gucgucgcgu cguuuauuuu uagucggaau uutagcgtuu 780

cggggaguaa gcggggaguu ucgggcgtuu ucgguuucgg uuuaggguuu tguttgtggu 840

uuucgutuuc guuacggggu atgggaggua ggtaguuuag uutgcguuag gauauucgtg 900

gcgggcggaa uucguuaagg aucgcgaagt uuagagaaag gaagutgagg agutguucgu 960

ucguuuucgg utguaguuuu aguaggguuu tuuuucggtg gcgcguauuc gcgcgcguau 1020

autcguauau cguauutuag cguutguucg guutcguuuu uauucgcgag cgucgaauut 1080

uutggggucg gatguuatgg gtaauaautt utuuagtatu uuutcgutgu uucgaggaaa 1140

uucgagucgc gcgucgcggg guuauuuuua gaauutuaaa ggtaggutuu ucggucgagu 1200

<210>199

<211>1200

<212>DNA

<213>智人

<400>199

tgutuuuaag tguttatgag uuuatgtata tguauatttg tgtgauatga tguagaagaa 60

tagtguaggt utgtgttggg gtgtgtggtg tgtgtgtatg tguatggtta aagggatagg 120

ttggtgtggg ggggaaaagu utggattutg gtgutguaut guutgggttt guattuuagu 180

uttguuauut tttaggtgag uaguututut ttgtutuagt tttutuatut gtaagauuat 240

uatuatuatu ttagagatgg tauutgttga tutgttgata atgautgtaa tautgauutu 300

atuattuagu utgtgaggau uaaaggagtt aatauttgua aaguuuttgg aauagaguut 360

ggaagaagau agaaacggtg ttaguauttg gttaauagut uuatuagutt gattgtgaau 420

ututtgaggg uagggacgat gtutgttttg uttuuuaggg ggtuuuutut uauutaguag 480

gauututgua tgtagtaggt guatgaggut agtgaatgaa tggutgtcgg uutgggcgtt 540

uagggagggu tgtgtgtgtu autauatuuu tgagatgggg utgtgtgtga tggggatgtg 600

tgtgcgtgtg cgcguututg utcgutttut ggagutcgut gutatttuag gaaguutuua 660

gtutuutuut uuttatgtaa ataaauatga uagatuuuat cggutgtauu agcgcgggag 720

gtggggaggu tggagtgggt gggagcgggg aggcggcggu cggaggggtg tgcgtgutgc 780

gtgcgcgtgt ggucggutgg ucgcgggcgg gcggcgtgcg cgtgtgucgg agggggcgcg 840

tgggggcgcg tgggggcgcg ggagggguut cgguuutguu atgucggtut ucguucgcgg 900

gggaggagac gggggaggag gaggggagua gucggucggg gcgautcggt gauuagucgg 960

ucgguuuagu agaggtggut guautguucg tcgucggaga tggggggaua gatuauucgg 1020

aguaututuu acggtaaggu uucgcggatg uutgcggguu cguuuauuuu aguucgagau 1080

cguutgggga ggucgggcgg aggggcgutg gggutgaggg uttggtuatg uuuutauttu 1140

tuautuuatg gaggggtutg gggutgtgtg gggguauutt ttggtggtgg guautggggt 1200

<210>200

<211>1200

<212>DNA

<213>智人

<400>200

gaucguutcg guututuaaa gtgutgggat tauaggcgtg aauuauuatg uuuaguutat 60

uuttttgttt tuuatuutgt gttgguttgg tgggggagag gaggtgttga uacgtggagg 120

auauauatat aagguattut tgggtgautt cgtuatuaut ggauuutatu tutuaaaatt 180

uuagcgaaat utgututtuu utttaaggag tgaaagaagg gtuaguattu uagaagttuu 240

tggtuatauu uaggutttta atgaattguu autggggaat uaguatuucg ttgutgtaag 300

gautataaga tggcggattg tgagaguata gggaaaggtu tcggaggtut uttgtuuttg 360

utuuacguag gtutttutgg uutgaaaatu ucgttgaaga gaguagutut tgagagtttg 420

utuuaagttu uutcggggtg atuaguauua cggauagcgg uuagggcguu uucgaggauu 480

cguagguagg uagggtguau agcggcgagu aggtgutgcg utacgtgcgg guuagggaau 540

tcgcgcgggg aggggagagg cgucgcgggt ggcggggtut tggucggggu tgttttcgut 600

gtgagtuauu ucgtgutuuu cgcgutuacg tcggtuutcg gaaagucggg gtuutuuutg 660

uuttttuuag uaacggtggg gtggggaggu aggaagaaag cguuaauuta ggauauutgg 720

auatttguag gaaaggaaga agcgggagac ggggauttgt utgtgtutuu agcgcgttuu 780

tguuuuucgg uucgauucgg uuuatttuta tauaaggtcg gututguucg gtutuuauut 840

uuuacgtcgu aggcgcggag gggutuattu ucggguuutg atutuagagg uucggaatgt 900

ggutgataaa tuagagataa uuutguatgg uaggguaggu ucgauautua gutuuaggat 960

aaaagguuac ggtgtuucga ggaguuagga ggaguauuuc guaggutgag gguaggtggg 1020

aaguaaauuc ggacguatcg uaguaguagu aguaguagua gaaguaguag uaguaguutu 1080

cguagtuuut uuagagauat ggatuuuuag auaguauutt uucgggcgut uutgutuutg 1140

ututtuttgu atutgguttt uutgggaggt cgttuuuauu cgutggguag uuucggttua 1200

<210>201

<211>1200

<212>DNA

<213>智人

<400>201

aggaaagttu tgguatttgg uagattaagu aagtgtuttg atttgaagtu uagtttagtu 60

uuaatautuu utuuuauauu uauuauatcg uauaatttgg ttttgtttat ttautuuagg 120

ttaaggtaga gtututtagu ttggtttgag tgutgtautu ttutututgg tutgatattt 180

ggaautaaag uuaaguuaga autuuagggu uaagggggat gttgaaaatt gtutgagtuu 240

uuagauuauu utguuagutu atgguaaagg gagggatuag agguuauagg gaaaguautt 300

uagutgutut tuauaguatu auuututuuu uatttaatgg tttaggttaa uaggautttt 360

tuuttgaggu ttgggauacg gaagggaguu tuuuutaaau uagguuuttg gagaguaggu 420

uuuaggggag uagtguaaut uauuttuaua uuuauaagac ggutuutgau ttutgutuuu 480

tuutuuuutu uuuaaagtgg aauagagaga atatgattuu uuacgauttu uauatuauag 540

tttuuaaaua atggggaaat cggagguutu uucgtgtgua gacggtgata tttaucguua 600

aatgcgaauu agguagatgu uaguuuuagu acguacguag gtaauttuau uutcguutua 660

acgauutuag aggutguucg guutguuuua uacgggggtg utaaguutuu cguucgttut 720

aagcggagau uuaacguuat uuataattaa gttuttuutg agggcgagcg guuaggtgcg 780

uuttcgguag gauagtguta attuuaguuu utttuuagcg cgtutuuucg cgutcgtuuu 840

ucgtutggaa guuuuuutuu uacguuucgc gguuuuuutt uuuutgguuc ggggagutgu 900

tuuttgtgut gucgggaagg tuaaagtuuc gcguuuauua ggagagutcg guaagtatat 960

aaggauagag gagcgcggga uuaagcggcg gcgaaggagg ggaagaagag ucgcgaucga 1020

gagaggucgu cgagcgtuuu cguuutuaga gaguaguutu ucgagauagg taagggcgua 1080

gcgtggggga uucgtgutut ttuuucggga tuuuutgtuu ucgtuutcgc gatguagtcg 1140

gucggutucg gutucgaagg cggauutggg cguututggu tutucgcggt uucgagttut 1200

<210>202

<211>1200

<212>DNA

<213>智人

<400>202

gacggagutt ggatututut tgtggtuuaa agggaaagga ttgutgaatg taaaguuaat 60

gtuauuagaa aagutgaatu uauaagagag tuutggagtu uaaaagagua tutuatgggg 120

aatuaggaaa gttutgguat ttgguagatt aaguaagtgt uttgatttga agtuuagttt 180

agtuuuaata utuuutuuua uauuuauuau atcguauaat ttggttttgt ttatttautu 240

uaggttaagg tagagtutut taguttggtt tgagtgutgt aututtutut utggtutgat 300

atttggaaut aaaguuaagu uagaautuua ggguuaaggg ggatgttgaa aattgtutga 360

gtuuuuagau uauuutguua gutuatggua aagggaggga tuagagguua uagggaaagu 420

auttuagutg ututtuauag uatuauuutu tuuuuattta atggtttagg ttaauaggau 480

tttttuuttg agguttggga uacggaaggg aguutuuuut aaauuagguu uttggagagu 540

agguuuuagg ggaguagtgu aautuauutt uauauuuaua agacggutuu tgauttutgu 600

tuuutuutuu uutuuuuaaa gtggaauaga gagaatatga ttuuuuacga uttuuauatu 660

auagtttuua aauaatgggg aaatcggagg uutuuucgtg tguagacggt gatatttauc 720

guuaaatgcg aauuagguag atguuaguuu uaguacguac guaggtaaut tuauuutcgu 780

utuaacgauu tuagaggutg uucgguutgu uuuauacggg ggtgutaagu utuucguucg 840

ttutaagcgg agauuuaacg uuatuuataa ttaagttutt uutgagggcg agcgguuagg 900

tgcguuttcg guaggauagt gutaattuua guuuutttuu agcgcgtutu uucgcgutcg 960

tuuuucgtut ggaaguuuuu utuuuacguu ucgcgguuuu uuttuuuutg guucggggag 1020

utgutuuttg tgutgucggg aaggtuaaag tuucgcguuu auuaggagag utcgguaagt 1080

atataaggau agaggagcgc gggauuaagc ggcggcgaag gaggggaaga agagucgcga 1140

ucgagagagg ucgucgagcg tuuucguuut uagagaguag uutuucgaga uaggtaaggg 1200

<210>203

<211>1200

<212>DNA

<213>智人

<400>203

ggattauagg uatgtguuau uagguuuagu taatttttgt atttttagta gagatggagt 60

ttuauuatgt tgguuaggut ggtuttgaau tuutgauutc gtgatuuauu utuuttgguu 120

tuuuaaagtt utgggattau aggagtgagu uautgcguuu aguuauattt aaattttaga 180

gtataattat tgutguttat aattagaagt gagaagautg ttttgaagta agggauttuu 240

utgguuauuu tcgutaaaat tguaauutta uuutuautuu atttutuutt ututguttta 300

tatttutuua aaguauttat atgataataa autgtataat aucgtautta utgtgtttut 360

uatgtatuuc ggutauaaut gtuaautgcg tgggautggt tttgtutgtt ttgttuuutg 420

ututatuuut ggagcgtaaa guagtgtutg gtatagagtg gatauttaat agatattcgt 480

tgaaucgggu uagtggcggt ggutuacguu tgtaatuuua guautttggg aggcggaggu 540

agguagatua uttgaggtua ggagttcgag guuaguutgg uuaauatggc gaaatuucgt 600

ututautaaa aatauaaaaa ttagucgggt gttgtggtgu atuuutgtaa tuuuagutau 660

ttcggaggut gagguaggag aatcguttga auutgggagg cggacgttgc ggtgagucga 720

gatcgcguua ttgtautuua guutgggcga uaaagagaga uatcgautua aaaaaaaaaa 780

aattcgttga acggaatgag tgaauaaaua aatggatgga tgagtgaatg aatgaacgaa 840

ggaauaagtg aucgutcgau uttutauagc gauagcggcg uaggcgutuu cguauuaaua 900

guuuuuuauu ucguuaucgu uagagggcgu agauaggucg ggtuucgagt gtutgtuuua 960

gguuuucguu uuauaggatu ucgguucggg aguuuucgat guagggauuc guucgggaut 1020

utgggtuuuc guuuatauut uaauttcgua cgautgcgtg uutuaagucg acguagcggu 1080

utaututcgu autguagacg gggaaautga gguutgaggc ggucggggtg ggguagauut 1140

uucggcgagu ucgaguuuuc guuuucggut aguuucguuu tgguucgtaa gaaguauucg 1200

<210>204

<211>1200

<212>DNA

<213>智人

<400>204

aataaauttu uatgttgttg ttgttgtttt gaaacggagt gtuaututgt uauutgggat 60

ggagtguagt gguauaguut tggutuaucg uaauutucgu utuutgggtt uaagtgattu 120

tuutguutua guutuutgag tagutgggat tauagatgua uacgauuacg uutggutaat 180

tatttgtatt ttgagtagag atggggtttu auuatgttgg uuaggutggt gttgaattuu 240

tgauuttaag tgatutguut guuttgguut uuuuaagtuu tgggataaua gguatgaguu 300

autguauuua guuaaauttc gaggtatata attaaaagtt taataaguuu tuaguutaat 360

tttaaaattu agattutttu tttutttutt tutttcgttu tttutttutt tutttutttu 420

tttutttutt tutttutttu tttutttutt tuttutttut ttttutttut ttuttgataa 480

uattattatu atagtutggt agattutgtu tttutataat aaaaatuutg tgatgttgtt 540

uaaagaaaut uaatgggutt tutgtatgtt tauuaaggaa ttaaaatutt aauaaaggtt 600

ttuaauauaa gaaatautuu uttttgtaag aattuttuat aggtttttut aguauaagtt 660

tgtttttatt gaatgataut tgatggttut gtatgttatt tuttttutau tauatataat 720

tttgattagg ggatauatta aatattttaa aautatuatt tutttttuua gaauaatuat 780

aauatgtttt guttuttgtt gutttaaaag gaauatttta agttgutttt ttauaauaat 840

aagtgtgaaa ggaaatguua aaatauaaau aatttuautt uttgttggaa tttgauattt 900

uuautaguta agtaatataa auatguatua uutaaatgag uagtatttta ataguatcgt 960

tttuauattt taattgttgt uauatttutt utttgtttag ggagacgtut ggtgaauauu 1020

cgtgggatut aaagaauaag taagatttaa aguatautgg gttgtgtguu tggutttuau 1080

attttattta ttttattgut taatagtgtt tutttautau tgtgggttgt aguttaaaat 1140

tgttagaaat tttattatgg agtataagga ataaaagtga acgttuaaua utttuaaatt 1200

<210>205

<211>1200

<212>DNA

<213>智人

<400>205

uutguutttg uatagaattu utggaatguu ttttcgtuat uttgttaaaa tuutggttaa 60

auttuaaggu utagtttgag auautatttu uatgatgtua gtuttgatuu tatuttttat 120

aguattatut ggttttuutt uutggcguta atuauttatt aaattgtaut aatuatutgg 180

tgtauutgut ttattttuuu tautaatutg gaaauaaaaa taatagaauu tgautuatut 240

ttutguuttg agauauuttg tgutgtuaut uttgatguut tguauauagt aggtgututa 300

aaaatagttt gtgguttttt gattttauag agaagautga ggaaattaaa uuuttguuua 360

ggagguatat aaaaatuutg ttaaatgaaa gaggutuatg utaautattg ttttgautta 420

ttgatguuaa autagauttg aauattgatg tgtuttuagg gaagaaguua aatatgutag 480

tgtaaaaaat tutaauutut gutatttauu tggagaagtt gaattaguuu tgtuatttua 540

autgatguua aaaaaguagu ttuuattatt gtgtuagtaa tagautttta tuutguatgg 600

aggaauttut uttaaatutt tutuatagua utggtgtgut tutttguaut gatgtattta 660

cgtaatgttt uataagaagt gauagttuut tttttaggtu tttguuuaaa aggtgguata 720

aguaaagaat gaaagtuaag gtggttggut ttaggagagu utaaaattgg gaatgcgaga 780

gutuuuacgt aauauaaauu cggatagtut aagautuuta uattttauaa auuaagttat 840

ttuuttuuta atauaaauaa agtatgauag ttauaattta ttgtgtattt auaatggatt 900

gtgtutgtua tggtgattgt gatggaauua ggggggaaag agtaagaaat utaaguautt 960

ttgtgttttu ttuuttttut tttututtuu tuuucguttt uaggututga aagtgttuua 1020

gutgaaattt uagatcggau agautcgutg cggutucgga gguagtgatt uuaagutgut 1080

cgcguacgut gutguuaagu tguaggatgg tguacgtagu uaggutgutg utgutgutuu 1140

tuautttutt uutucguacg gatgutgaga gtaaguuatt utuuuuttut utagggggut 1200

<210>206

<211>1200

<212>DNA

<213>智人

<400>206

aaguaaauut agataaatgg gauttuatuu aautaaaatg uttutguauc guataggaaa 60

taatuaauaa aatgaaaaaa uaguutatag attgggagaa aatatttgtg aguuatatat 120

utgataaggg gttaatatuu aaaatauatt acgttuauag aautuaguua aaataaataa 180

ataaaauauu uagttaauta acggguaaag gatgtgaatg gauttttttt ttttttuuag 240

aggaagtaua aattguuaau aggtataaga aaaggcgutu aaaatuauta atgaauaggg 300

aaaaguuaut aggtatutuu tuauauutgu taggatgaut gttataaaaa agataagcga 360

taataagtgt cggtgatgtg cggaguaaag ggaauuttgt auautggtgg tgggaatgcg 420

gautggaaua guuattatgg aaaauuutac ggaggttuau tuaaaaagtt aaaaauagaa 480

utauuaguuu agtgttatuc gtuuttcgtt aagttuaaag tuacggtguu auttuutttu 540

uuatutaaag gggautgutc gcgauuuaag uuaagguucg uaagtgtggu tutuuutgcg 600

gggagagtag gguaggaggt ggatttuuag guuagaggut tuuaggutgg guucggauuu 660

uacgucgauu ucgguuucgg ggggggutua gcgauutcgg cguutuutua gguuuuuagt 720

gaauutucgg gguuuataaa ggutuuaggu cggutuuucg gagguuuauu agcgggcgtu 780

tggguutuuu tucgcgucgc gaucguuagg aggcgucguu cgggagagga agtuuagutg 840

gguucggucg gguttcggag gcgucguucg ggagaggaag tuuagttggg uucggucggg 900

uttuagaggc guagggcggg agucguutcg cguagggtuu tuuuuaaguc ggcguuaggu 960

uutguuutcg tucgguuutg uuutcgtutg guuucguucg ggucgcgagu autggcgggt 1020

tutgggtuut gtgaucggtu aggcggcgtu agcgggcgcg gcggagggut ggucgguutc 1080

gggggagttt ucgcggucgu cgggggcgcg gcgguagagc gcgaggucgg guaggggguu 1140

agautcggag tcgaggcgcg uucgauaguc guagcgutua tggcgggcgg aggagucggg 1200

<210>207

<211>1200

<212>DNA

<213>智人

<400>207

aguaaauuta gataaatggg auttuatuua autaaaatgu ttutguaucg uataggaaat 60

aatuaauaaa atgaaaaaau aguutataga ttgggagaaa atatttgtga guuatatatu 120

tgataagggg ttaatatuua aaatauatta cgttuauaga autuaguuaa aataaataaa 180

taaaauauuu agttaautaa cggguaaagg atgtgaatgg autttttttt tttttuuaga 240

ggaagtauaa attguuaaua ggtataagaa aaggcgutua aaatuautaa tgaauaggga 300

aaaguuauta ggtatutuut uauauutgut aggatgautg ttataaaaaa gataagcgat 360

aataagtgtc ggtgatgtgc ggaguaaagg gaauuttgta uautggtggt gggaatgcgg 420

autggaauag uuattatgga aaauuutacg gaggttuaut uaaaaagtta aaaauagaau 480

tauuaguuua gtgttatucg tuuttcgtta agttuaaagt uacggtguua uttuutttuu 540

uatutaaagg ggautgutcg cgauuuaagu uaagguucgu aagtgtggut utuuutgcgg 600

ggagagtagg guaggaggtg gatttuuagg uuagaggutt uuaggutggg uucggauuuu 660

acgucgauuu cgguuucggg gggggutuag cgauutcggc guutuutuag guuuuuagtg 720

aauutucggg guuuataaag gutuuagguc ggutuuucgg agguuuauua gcgggcgtut 780

ggguutuuut ucgcgucgcg aucguuagga ggcgucguuc gggagaggaa gtuuagutgg 840

guucggucgg guttcggagg cgucguucgg gagaggaagt uuagttgggu ucggucgggu 900

ttuagaggcg uagggcggga gucguutcgc guagggtuut uuuuaagucg gcguuagguu 960

utguuutcgt ucgguuutgu uutcgtutgg uuucguucgg gucgcgagua utggcgggtt 1020

utgggtuutg tgaucggtua ggcggcgtua gcgggcgcgg cggagggutg gucgguutcg 1080

ggggagtttu cgcggucguc gggggcgcgg cgguagagcg cgaggucggg uaggggguua 1140

gautcggagt cgaggcgcgu ucgauagucg uagcgutuat ggcgggcgga ggagucgggg 1200

<210>208

<211>1200

<212>DNA

<213>智人

<400>208

aagtguuuau uuaaataguu tuatuattgu tgagggtutg tauatgauag tgautggggc 60

gtagguagut guauauauua gggutgagtu uuaguauacg tgttutauut gtgtgautuc 120

gaguuttaut tttutuatut gtauauagtu tutgtutuaa ggutattgga atgagtuaat 180

gatagagtgu acgtaaatua uttguauaga gagttgttua aauaatggta gutagaautg 240

utattgatut attgtggggt aattgtutta autgutttga aggattuagu uutatgtgtt 300

uutttgtuua gtuagatggg aaaatataaa tgaguuuttu tuaatgttag gaatgauaag 360

atuagguuaa gauuuututt tutuagauta tucggaagat auauagatga uutggauagt 420

gtutguaggu tuutgtgtat uutgaggutt uutgaggguu aagttutatg ggtgggaagg 480

uaguttgutu tutaggttgu uataaututg uatutgattt guatgtgttt gtggtgauuu 540

tguagtttut tutgguattt uuaauttaaa atattgutgt ttuuuuaggu aggguagata 600

ttgatttttt tuttututaa uuattucgat tgauucggut uuuuuauuua gcgaatgggg 660

gagggagggg gtgggggtga ggaagtggat gggggagaag ggaggaggga tggtgttguu 720

uttataguta guauutttta utucgtggaa uutgagtuau cggggutgat gagaatgggu 780

tutttuuaga aguaagtgua tgatgaagaa agaauagagg gaatgttuuu uutcgggtuu 840

atuutggtuu uttutttuuu tguatuuutt atatgauutg uagttuuutg agtuuauttg 900

uuaucggggg cgggtgguau uuaggcggcg gggaggcggg ggaggggcgu agtgauaguc 960

gagucggutt tgaggaauut tguagaggaa gtgguttuag aautguttta cgcgaggggu 1020

aggaaaggcg cgggaggcgg gggaggtgcg gagatggcgu tutguacggc ggcggaggga 1080

gggcgutggc gucggggaua cgaaaucgua gaguucggac gagtuaggga gtgaggcgcg 1140

agucgggcgu ucggggutut guaggcguag gcggcgcggg gauaggagua ggttaucggg 1200

<210>209

<211>1200

<212>DNA

<213>智人

<400>209

uttgaaguaa guuttuacgg gggaaagtgu cgggagaaag gagatututu tttgggtuuu 60

atgagtgaau uatuuatauu aggttuuaut taggguattt aggggaautg gtatutuuau 120

agtaattaut agaguagutu tggggaacgg agggttggut aaggaagaaa agutuuuuua 180

auuuttgggg cgagggagcg ttututuaat ggaguuuuuu uaautuuuut uuauuuuuua 240

uuagtuttuu aggaaagagg aatauuutau ucgguagggu tgcgaaggaa ggggaaatuu 300

aauuagagcg aaagtcguac gcggauagut utguuaguuu ttggagguat ucggcggtua 360

uuuacgggau aaagcgcggu tgcgggagcg cgcgcggggu attucggauu cgcgtcgagu 420

tucgututag agggggcggc gggcggcgau aagucggaga gaggaagggu uaaggaguac 480

gguuutuutg tcgguauuat uagcgggaga gtggcgagcg gacguutaga cggagggguu 540

utautuagau uuuatcgagu uagttuuuaa guttttuuut ucgauutgut uuutuucggg 600

gcgcgtgagg gtgcgggtcg ggggtgaauu tggtgttggg gaaagtgatt gguaagggaa 660

agagguaggg utgaagguut aggguuuuuc guagaaatgc guuututgag utgtautgta 720

uagaggcgut uututgcgga atuutguagu tgutuuaggt gaagacguuu uuaaatuuau 780

autcgcguag acgtcguutg guacggauuu tauuuuuttc ggtucgtcgg cggttututt 840

gggtcgtuut tuutguuaut ucgaututuu ucguuuucgu uucguuuagu aggutgcggt 900

tuutttaaag gcgcgutggt gtggggcggu uuuttututc ggggutggut cgggagtagc 960

guagtcguua aagucgucgu tguuaaagut gucguuauta gucggguatg guuatggcgt 1020

uuucgguuat cggguagcgu ucgtauucgu tautattgga uuucgagucg ucgcgutatu 1080

tauagaguut gagcgguuuc gagutaucgu cgucguuuuu cgaucggtuu tcgcguutut 1140

gtgtuucggc guuuututuu autgcguucg gggcgcgcga ggggcguagc guucggaggg 1200

<210>210

<211>1200

<212>DNA

<213>智人

<400>210

ttuaagatgg tgaucguaga gcgttaaauu agauaagggt uuatgaaggu ttgaaguaag 60

uuttuacggg ggaaagtguc gggagaaagg agatututut ttgggtuuua tgagtgaauu 120

atuuatauua ggttuuautt aggguattta ggggaautgg tatutuuaua gtaattauta 180

gaguagutut ggggaacgga gggttgguta aggaagaaaa gutuuuuuaa uuuttggggc 240

gagggagcgt tututuaatg gaguuuuuuu aautuuuutu uauuuuuuau uagtuttuua 300

ggaaagagga atauuutauu cgguagggut gcgaaggaag gggaaatuua auuagagcga 360

aagtcguacg cggauagutu tguuaguuut tggagguatu cggcggtuau uuacgggaua 420

aagcgcggut gcgggagcgc gcgcggggua ttucggauuc gcgtcgagut ucgututaga 480

gggggcggcg ggcggcgaua agucggagag aggaaggguu aaggaguacg guuutuutgt 540

cgguauuatu agcgggagag tggcgagcgg acguutagac ggagggguuu tautuagauu 600

uuatcgaguu agttuuuaag uttttuuutu cgauutgutu uutuucgggg cgcgtgaggg 660

tgcgggtcgg gggtgaauut ggtgttgggg aaagtgattg guaagggaaa gagguagggu 720

tgaagguuta ggguuuuucg uagaaatgcg uuututgagu tgtautgtau agaggcgutu 780

ututgcggaa tuutguagut gutuuaggtg aagacguuuu uaaatuuaua utcgcguaga 840

cgtcguutgg uacggauuut auuuuuttcg gtucgtcggc ggttututtg ggtcgtuutt 900

uutguuautu cgaututuuu cguuuucguu ucguuuagua ggutgcggtt uutttaaagg 960

cgcgutggtg tggggcgguu uuttututcg gggutggutc gggagtagcg uagtcguuaa 1020

agucgucgut guuaaagutg ucguuautag ucggguatgg uuatggcgtu uucgguuatc 1080

ggguagcguu cgtauucgut autattggau uucgagucgu cgcgutatut auagaguutg 1140

agcgguuucg agutaucguc gucguuuuuc gaucggtuut cgcguututg tgtuucggcg 1200

<210>211

<211>1200

<212>DNA

<213>智人

<400>211

tautuaggag guuaagauac gagaatcgut tgaauutgag gggatggggg guagaggatg 60

uagtgagucg agattgucga gatagcguua utguattuua guutggguaa uagtgagagu 120

utuuatutua aaaaaaaaaa aaaaaaatgg auttuttuut uattgauutg tggtggutuu 180

aagguuatua aaaaaaaaaa aaatggautt uttuutuatt gauutgtggt ggutuuaagg 240

uuatuatutu auaguutttt tttttttttt tttttttgag acggagtutt gutuuuttgu 300

uuaggttgga gtggagutgu atgatutcgg utuautguaa uutucguutu uuaggttuaa 360

guattutuut guutuaguut uutgagtagu tgggattaua ggcgcgtguu auuacguuua 420

gutaautttt guatttttaa tagagacggg gtttuauuat attggtuagg utggautcga 480

autuutaauu tuatgatucg uucguutcgg uutuuuaaag tgutaggatt auaggcgtga 540

guuautgcgu ucgguutuat utuauatutt tuttuututg uaguauacga uacguuutag 600

ttggaaauaa agtcggagtt tgtggattgg gggaagggcg gggtutaauu tuaggtuagg 660

cgucgtguaa ggtauatutt gguauucgga agagguuuag tauagttguu uucgaggtga 720

uucgauutuu uutauuaatt gaggcguuut tgttguuagg uttgcggcgg gggagcggcg 780

ggggagcgac ggggatgcgu tuattggtua aggaaggggc guutgttaut agaggcgaga 840

aucggaguuu attggtcgga auauutuaua atggauuuua gcggcgcgua aaatuuttat 900

gattggtttg utggutguut cgggagauuu tgttguuagg atauttggcg ttuucgauuc 960

gauuuucgtt uuuuattggu tgtuagggua aaagucguua tutaatgagg agcgaggtgc 1020

ggtguuucga agcgutcgut tuucgcggtg cgatutagtu utguagtagg cgguucgggg 1080

uuauaucgcg gucguuuaag uuagtguaag guuuaggggu utgauatcgu tuuuagcgut 1140

cgaggaucga gguutgutgt ggaggauauc gtgutuuutc gggauutgut utggattucg 1200

<210>212

<211>1200

<212>DNA

<213>智人

<400>212

uaaaaaguag ucggggatgg ggcgagaaua gaggauttuu uuautgaguu uauatuuaau 60

utuauuuaga auuuuttutu aggtuuagtt gutgutuuut attaggggta aatgtgttta 120

tgcguatuat ttuuatuatt tutttggggg aaaattggat tutttuutuu tuutcgutau 180

tcgututucg aututguuag uuuatutuut gagagttutu utgtgtaagg gatguaaggg 240

uuauuaguau uaggtututg aaaggacguc ggaguuagtt tucggtttuu aagggttgga 300

uuagtgutgg aggggggaat uauaaautgu uuttuuagga uuutauuutu tutautauuu 360

uaggatgutg aaaaagguta ttutguutut uttuuuutgu tuagututtu uucguutuut 420

guutucgguu uuaguagagg ucgcgutuuu autgcguutu tcguututga gaaatggcgu 480

aguaagcgut ucgcggagag uutggaggcg gggcguuutt ututgagtuc gcggggtcgu 540

auuucgaguu agtcgguuag auutguatuu cgcgtaguat uuutguuutu tutgtguagc 600

ggaaagggua aaagguaggg autguaagcg ggcgcguauc gggtaggaag agcggututg 660

cgtaggtgcg cggauucggg utuutgggtt uuatuuucgu cgcguauutc ggggtucgua 720

uucggutuut gucggguuut tttcggucgu auuucgutuu cguauuucgu tuutuuuuaa 780

guuuuauucg guuuaagucg cgcgtuucgu autgagutuu tauacgcguc gcguuucggu 840

cguauuucgc guaguuagag uaaguautgg aguuucguuu uttuucguau uuuauucguu 900

tucgguuucg uutgguuuau uuutggaucg uuuucguuuc guuucguuuu tauucgutuu 960

tucggcguag ucggcgutta uutcguttua gtuucgcgau cgaaguaggg cgcguaguag 1020

cgutgagtgu uucggaacgt gcgtcgcguu uuuagtgtuc gtcgcgtucg ucgcguuucg 1080

ggcggggatg gggcgguuag autgagcguc guauucguua tuuagauucg ucgguuutag 1140

ucguagtuuu tuuagucgtg guuuuagcgc guacgggcga tggcgaaggc gacgtucggt 1200

<210>213

<211>1200

<212>DNA

<213>智人

<400>213

gauutuaaaa aguagucggg gatggggcga gaauagagga uttuuuuaut gaguuuauat 60

uuaauutuau uuagaauuuu ttutuaggtu uagttgutgu tuuutattag gggtaaatgt 120

gtttatgcgu atuatttuua tuatttuttt gggggaaaat tggattuttt uutuutuutc 180

gutautcgut utucgautut guuaguuuat utuutgagag ttutuutgtg taagggatgu 240

aaggguuauu aguauuaggt ututgaaagg acgucggagu uagtttucgg tttuuaaggg 300

ttggauuagt gutggagggg ggaatuauaa autguuuttu uaggauuuta uuutututau 360

tauuuuagga tgutgaaaaa ggutattutg uutututtuu uutgutuagu tuttuuucgu 420

utuutguutu cgguuuuagu agaggucgcg utuuuautgc guututcguu tutgagaaat 480

ggcguaguaa gcgutucgcg gagaguutgg aggcggggcg uuuttututg agtucgcggg 540

gtcguauuuc gaguuagtcg guuagauutg uatuucgcgt aguatuuutg uuutututgt 600

guagcggaaa ggguaaaagg uagggautgu aagcgggcgc guaucgggta ggaagagcgg 660

ututgcgtag gtgcgcggau ucgggutuut gggttuuatu uucgucgcgu auutcggggt 720

ucguauucgg utuutgucgg guuuttttcg gucguauuuc gutuucguau uucgutuutu 780

uuuaaguuuu auucgguuua agucgcgcgt uucguautga gutuutauac gcgucgcguu 840

ucggucguau uucgcguagu uagaguaagu autggaguuu cguuuuttuu cguauuuuau 900

ucguutucgg uuucguutgg uuuauuuutg gaucguuuuc guuucguuuc guuuutauuc 960

gutuutucgg cguagucggc guttauutcg uttuagtuuc gcgaucgaag uagggcgcgu 1020

aguagcgutg agtguuucgg aacgtgcgtc gcguuuuuag tgtucgtcgc gtucgucgcg 1080

uuucgggcgg ggatggggcg guuagautga gcgucguauu cguuatuuag auucgucggu 1140

uutagucgua gtuuutuuag ucgtgguuuu agcgcguacg ggcgatggcg aaggcgacgt 1200

<210>214

<211>1200

<212>DNA

<213>智人

<400>214

tuuuuuuatg gaggutguuu tutagttcgt uutttagagg aaguatgauu aagggtutgu 60

tggtautttt ututuuutut utaagaattt uutuaggaga ggaaaaagtt agutttuttt 120

tututgutuu tgagtguuat gguutguagt acgtgauuag tuuttgguau agagtuautu 180

agggutuatg gtagatgutt agcggtuaua guuagtagut gcguagtgtg guaguagutg 240

agatuuatau tguaguutga aagttgtgtt tuaguttutg aggttauaag tgtatuuagt 300

gtttauatua gagataaagu uuuutttuuu utututuuta cgggaguuut uaauaagaua 360

gatauacggg ttgggtggag tgagauuaua tuuaguagag guaaaguttg utaaaagaga 420

gaggaggagg agggggagag ggaggaggcg guacggcgtu uuttgguagu tucgtguatg 480

utgcgguagt tguaauagga gaaucgagta uuagttgutu aauautttat uautttguat 540

tgututttut uutuuuttaa gtgaatttuu attttgaggg tauagutuua uaggagaaag 600

gtgtggtggt ggtagtggtg gagggtgtut gtggggggga tggtggtgcg acgggagttg 660

gaatgtuuag tgtggggaag uaaaggagtg uutautagga tgcgaatauu auttgguuut 720

gggutcgutu cgutttaguu ttuuuututc gutggggaga aauaggcggt ttgtgaggga 780

gautgagaga ggggcgtgtt tgtggtggtg gcgguuuatc gggggtuutt gtuututucg 840

aatauucgga utgutgaggg gaagggucgg ggggguuucg gcggttguua tggtgacgua 900

gggtcggcgg utuagcgucg tagagauaaa gucguucguu cguuaguucg utagutuutc 960

gcgcgagutu utuutuuacg ggaauutuuu tuuuutuuua ggcgucgucg uagucggagc 1020

ggutuucggg uuutgggucg ucgucgguua ggtaaggcga tcgcguucgc ggucggggag 1080

gggtcggcgg gacgucgggu utuuuuaacg utgggguagu aguuaguuuc guagtuutgg 1140

acggcgucgg gucguuuaag cgcgucgagg agagggggcg guaaauttcg ggucgagcgg 1200

<210>215

<211>1200

<212>DNA

<213>智人

<400>215

gagggagaga tguagggagu tggattttag utuutaaggt agaaaatttu uaaaaggutg 60

atuaaagatt aaatggutgu uttaaaaggt aatgagttuu ttgttagtgg aggtgttuaa 120

uuautguttg gtgggaagau autgtaagga ggattuaggu aagtgggaag gggguttttt 180

uuagtuuutg aaatuaatga ttutaauagg aaaagatgut ucggggtgcg gtgagcgutt 240

auututgutu ttguagagau autgauagac gttuattuaa uatutgttuu tguuagguau 300

tgtgcgcgut gaauauagaa gtauaguutu tatgaaguag ucgutgtagg uutuagagau 360

agutgataga tgtaauautg ttgtutuuat gtttuaaaut tcggtuatgg tuttautagg 420

tutuutuatt aaggggautu autatgtgtu uagtaacgut ttuttgttau uagatgauag 480

agagtuaggu tgtuagagtt uacgauttta ggtguauagt ttuauuutgt utggtuuttg 540

ggagacggag aaggggtuag gagaaaacgt gggtgaagag guaguaaagu cguaggagat 600

atgaautaat tgutuaacgt gggtgtagua cggattaggu uttttauagu aagcgutguu 660

aguagggaau tggtggatgt aututtgauu acgutcggut ggaututggg gaguuuaaga 720

cgggtaagau taggtuuucg guuuuaguag utggtggggg cgucguaggt tagagacgtg 780

aggucgcgag gutgagggut gtgaaggcgg tggguacgua cggcgtgucg gggucguutg 840

guttcgcggc gggggaggta auautgcgau auuucguaga cgutgtuagu cggggtcgcg 900

guuucgcgtg cguucgatua tutgautgut ggggagtgcg ggggcgcggg aguuaggcga 960

guuagcguag gcgcgcgutg uutuutucgt uuuuaucgag tuuuuagcgc gtgcgcgggg 1020

ucgtggucga gguutgcgcg ucguucgguc guutguautg cgcgcgcguu uauuucgcgt 1080

gggagguagc gggagggguu cggagaggtg tggagcggcg cggcgggagg utucgtgggc 1140

gguuacggga gauagcgucg gcgggagcgc guututcggu utttuutucg cguuuucgcg 1200

<210>216

<211>1200

<212>DNA

<213>智人

<400>216

ttagutuuta aggtagaaaa tttuuaaaag gutgatuaaa gattaaatgg utguuttaaa 60

aggtaatgag ttuuttgtta gtggaggtgt tuaauuautg uttggtggga agauautgta 120

aggaggattu agguaagtgg gaagggggut ttttuuagtu uutgaaatua atgattutaa 180

uaggaaaaga tgutucgggg tgcggtgagc guttauutut gututtguag agauautgau 240

agacgttuat tuaauatutg ttuutguuag guautgtgcg cgutgaauau agaagtauag 300

uututatgaa guagucgutg tagguutuag agauagutga tagatgtaau autgttgtut 360

uuatgtttua aauttcggtu atggtuttau taggtutuut uattaagggg autuautatg 420

tgtuuagtaa cgutttuttg ttauuagatg auagagagtu aggutgtuag agttuacgau 480

tttaggtgua uagtttuauu utgtutggtu uttgggagac ggagaagggg tuaggagaaa 540

acgtgggtga agagguagua aagucguagg agatatgaau taattgutua acgtgggtgt 600

aguacggatt agguutttta uaguaagcgu tguuaguagg gaautggtgg atgtaututt 660

gauuacgutc ggutggautu tggggaguuu aagacgggta agautaggtu uucgguuuua 720

guagutggtg ggggcgucgu aggttagaga cgtgaggucg cgaggutgag ggutgtgaag 780

gcggtgggua cguacggcgt gucggggucg uutgguttcg cggcggggga ggtaauautg 840

cgauauuucg uagacgutgt uagucggggt cgcgguuucg cgtgcguucg atuatutgau 900

tgutggggag tgcgggggcg cgggaguuag gcgaguuagc guaggcgcgc gutguutuut 960

ucgtuuuuau cgagtuuuua gcgcgtgcgc ggggucgtgg ucgagguutg cgcgucguuc 1020

ggucguutgu autgcgcgcg cguuuauuuc gcgtgggagg uagcgggagg gguucggaga 1080

ggtgtggagc ggcgcggcgg gaggutucgt gggcgguuac gggagauagc gucggcggga 1140

gcgcguutut cgguutttuu tucgcguuuu cgcgtuuuua gucggucgut ucgagaggau 1200

<210>217

<211>1200

<212>DNA

<213>智人

<400>217

auaaaaaaat tuuaatagtg attagtaaua auuagataut gtgauagtgu uuuattguua 60

ttuuatggga gatguaagag uattgtutua gtaataaaat atgatgttat uagguattta 120

tggutuutgg ggaaaaaaat guaattgutt gutgttttga tattatutut gautatgutt 180

guttatuatt tguuatttut atatttagta guuagtuatt ttgaagttaa aaaaaaatua 240

aggtttguat tgtaauuaua aauuagtutt tgtgaauagg aatuutggag gutattaatu 300

aguttttaaa ggaggtaagt uatggtggtg gtggggtatu tgaaattttg gaagttucga 360

gutuauttta agagttgaga tgggtgggag ggutgaaaau auuauuattu atuattuttu 420

agttatutcg agautuaaut taaauatttt taatuaaaaa gatgggaggg gauacgggtu 480

auatutuagg tttgggggaa tgtgtgtgcg tgtagatgtg aaaautgagu uaaaatattu 540

uautgtgaag agatutuuut tutcggutgg tggauatuaa uuttauuaag taatutttgg 600

aguaagtaau tauuaaataa agucgttuua aaauttutac gtaagutuut autttttaat 660

gagtacguat ttutuuuuat tttuttttuu tutuuaagga utgagatagu tggaguaagg 720

atgggtuuuu ututgatttc gtuuucguuu uaguuaatut gaguucggat gutaattagu 780

tgcgutuuuu tgatgaauac guutttgtua uaagtagguu cggautauaa aguuuagaat 840

guutuauuuu tuuutgatua atgagggutt atttaaatga tututgaggt uttggauuua 900

gguuaatuag utgtuagggu tuatgataaa tcguaatgua ttattgataa taataattau 960

tgggauatgc gcgttucggu cgaagggggg taaatttuuu aautuuagga atttgtggcg 1020

gagaggguaa ataautgcgg ututuucggc guuucgatgu tcguauuatg tcgaggcgua 1080

aguaggcgaa auuuuaguau atuaautcgg aggaggauua gggcgaguag uagucguagu 1140

aguagauuuc ggagtttgua gatgcgguuu uagcggcguu cgcggcgggg gagutgggtg 1200

<210>218

<211>1200

<212>DNA

<213>智人

<400>218

tgtaauatgg auutututgt gacgcguaag tattatutgg uagttauatg gtgucguutg 60

tguagutggg cguuauuauu aguttuutgu uutgtgcgat taaaagguua guttcgggga 120

uaguaguutu utuaacguaa agcgauuagu uutguuaggc gtcggutgua gutggtuuaa 180

ggttgacggt uuuagggucg uattutuutt ucggtuauut uagaututgg aaagagaguu 240

atggaggguu tuagagcguu uututguagt tuuttgagga aaauaagggu utuuuuutut 300

tggutggagu aguuaagtgu uuacggggaa aatggtuucg tuuauuattt uagguaaacg 360

uuuuuatagu tgtaataaau atgtgatggg tttuutguau uaagaaagga aaattttuut 420

taaaaataau aaaaagaggt ggggagggga ututaagttu uatttaagat tttuuaaaut 480

cgttgtgtut uatguatacg utgaggutta auatgaaaat ttggagcgaa agtuuuuacg 540

gttuauuaua gggaatgaag taaagtatut cgucggtagu tutaggtutc gtaaaucgtg 600

gagutuuttt agtataaggu uutattatgt guuauattag atgagaagaa aataagagga 660

aggatacggt agaguuttta gaatggggtt uagtuttagg autcgtagga taaaggaagg 720

tcgtttuuut ucgtttgagg uagggaatua aauaaaauau cgguaucgua gguaucguag 780

tcguautuut gggguutcgt ggutttuucg cgcguucguu ttgggggcgg ggaagaauuc 840

ggatggaauu auuuttguag uucggauuuu ucgucgtutt tgaatgguag cggggcggag 900

ttguuutuuu ttutgtgutu tgautggttt ggutucguau tutuututtc gtgattgggu 960

tttuutagtg uuagtuauag agcgacgutg gtutuuuaga ttgttguaga aggagacggc 1020

gtcgacgtut gautggautc gcggcgautt auutttuagt cgtgcgutuu tgatucggcg 1080

utcggaattt gtuuucggut tuagggutgc gggguutgga aggaggcgta tcgaggcggu 1140

tcgaaaacga tuuaggggag ucgaggcgut uututtgtua tuuuautuag cguuatgtuu 1200

<210>219

<211>1200

<212>DNA

<213>智人

<400>219

tttaaaagtu uuautgaaaa uttttttttt ttuuagatcg aaauauaagt ttaatagtua 60

ttuagatttu attuuagtut aaagaaautt atagaaatut aattatutgu uagaataauc 120

gutttaaaut gautgtaaga auuauagtta utttguagut aaaauagatt gttututtuu 180

uuuaaauaaa utcggauatt tagauaaata ttgutgutgt utttauattt tagaaatuag 240

tattaaggut uauutgttau tgaauauata cgagaaauag ttttgttatg cgtatuttat 300

atauatuatg tatauatttt cgtautttua uatgatgtgt ataataagat auauataaaa 360

autggttggu ttgtuatgag taaatguttt attutttaga gtgaaggaat attggataua 420

gaacgtcgtt uuatatttaa tuttguttta gaaaattagg atttatuttg gauauaguat 480

tttgaatata auauagguaa gttgagtuut gggggaaaaa ttgtattttt aaatttatta 540

tuaacggtgt utttcguatt tgagaaaaua uatttgaaga tguuuatgua gttuuttgga 600

agtaaautag gtuauuuauu autgaaauau uutcgguttu tguaaaaaga tgtgutttaa 660

agagaataga atggacgutc ggtatgttua tutaaacgau uttggguaag tacgtcgatt 720

uuaaggtaua atuaguuutu uuagacggut tttcgagtut uuutaauuuc ggtgggagag 780

gacgcggcgu uagaguuuag utucggutag ttttuucggg gguaggtgta guuttgggcg 840

cggggucggg ggagggguaa ggggcgggcg tggggttgga utgggacgtg ggautcggau 900

uacgguutgg gcgtggguut aacgacgcgg gaucgguucg uuutcgucgu tuuattgguu 960

auatutgtgu agaaaagguu ucgcgguuua ggggcguucg uagtgtuaut aggucggutg 1020

gggguuutgg gtacgutgta gauuagaucg cgauagguua gaauacgggc ggcgguttcg 1080

ggucgggaga uucgcguagu uutcggggua tutuagtguu tuautuuuua uuuuutuuuu 1140

cgggtcgggg gaggcggcgc gtucggcgga gggttgaggg gagcggggua gguutggagu 1200

<210>220

<211>1200

<212>DNA

<213>智人

<400>220

tgttutuuag aguaggaaau aaguttggag agtgcgataa utaguuuaag uttuauaatg 60

ggtgagtggu aggautgagg tttgattcgg gtututtuuu agagagauau tgggagagat 120

tuttguuuua ggtuttttuu uttuagguuu tuaggutuag uauutututg aauatutgtu 180

uutggggagt gagaatutga autaaaatgt aaguuaagaa aauauaggut uttuattgaa 240

tutttggaaa utuutttuut gggutgtagg aggauuttuu tgaguuttag guauttttgu 300

utttgutggu tutttuutuu aagtuaagua tattttatga utgtggaggt ataaatauaa 360

atatattaau attatatagt aaaauatttt gtttgauata aattttttut tutgattttt 420

auagaaaaua ttttuataga tutuuaaaag tatcgtgggu uutaagcgut gtagutaagt 480

cgtttutuut ttutuaguut uuagtutgau atgttuuaut atgguuttgg gaagaguaat 540

ggguucggag tcgucguatu taauuutgut gtaautggtc guaagtuaua gtttgutuat 600

utataaagtg agcgaaagta atgtaatutt tattgggagt agggaauatg aaggcgagtc 660

gatauagtaa gtaagucguu aaguatattg utagguauag aguaggtgtg uaauaaaagt 720

tatttutuag gutttuuutu ututgagcgu cgtuutuuag agggtucgga gtgtagutgg 780

gggttggagu aguaguutuu taggcgatgg gauagaguuu auagggtucg gtatguuacg 840

gtttuttcgt uagauuutgg gaatuuaacg tcguaaaata aauacggucg cgucgutaat 900

cguuagttcg gaggaaauaa aauagcgutg cgutggggga tutggguaaa atuaguuutu 960

uutuutuucg utuuttcguc gcgguuutuu uutuutcgcg utgututcgt tcguttggut 1020

uagutuagut uagutuagcg uagutucgcg gucguuaagu cgaggcgggu acggtutucg 1080

agtcgcggac guuagutucg agutuuutut utucgucgcg uutucguuag gtcgcguutt 1140

cgtcgggauu auttcgggua ggagtcgcgt ggcgaagguu tgcggucgcg guauaaagtt 1200

<210>221

<211>1200

<212>DNA

<213>智人

<400>221

agagggttua agtttagatt tuaggutaaa uttutgggut tagagggtuu tgaguatggg 60

autggataaa ggagggaagu uatuatutut tuagaagatg ttuagaaaag gguatauauu 120

uagtutatut gagutgggag agagutgutg ttatguuutg ggguaggggg atggatgaaa 180

tgguatttga gggutuagat tututttggg guaagauutg auttuutatg gautuuuagg 240

aguaguaggg gagttutgag aggaautgtg attgtuuaga gtggagtttu tttgagautt 300

guuutgtauu taauuuuaaa uagatttgat auttagagau ututaauucg guatutuatt 360

gtauagutgg gaaaautgag auuuaggagg aagggguutu tucgagatgu uauagtgagt 420

uaagagtuut uauttuagag ggutggagaa taatutautg agguaggguu aggguauutg 480

tutgagaggg guttutaagg utguaagutt ttuuuuttuc gtggautgua ttuauauutt 540

gttcggtuut gutggggucg gggututuut tuuttguuuu ttttuuttgg uaututttuu 600

auagguuutg tgtggtutgg gututaucga gaggtuuuua aggagagutg gcgtgtuagt 660

uaguuaagaa guaaguaggu agguaatguu aguatguagg tggcggggut gguaggggag 720

ucgguaggag ggucggauau ucggagucgg ggaautgtaa tgttuaggga atttuaattg 780

guattgutgt uucgttuuag uuaautggut aacggtgucg agtttgaatu agtgauucgu 840

utuutggtuu utuutuutta gucgguutut utuuutuuut uuttttttuu utuuutcggt 900

gguuttuuag gaggcgggag gcguucgutg tcgagguagu tgaguuucgg uaaucgutgu 960

tutucguutu tuuuutcgcg gggucggutu atggagcgua gggaucgggu tggututcgu 1020

cgaguuucgg guututttta guutcgtuuu uagagaggga ggagucggtg uucgguauag 1080

uuucgucggu uutagaagut uuuuacgcgu uauuatguut utgutggacg ttttutggtu 1140

ttguttuagg aaggtgaagg taagtgautg guuaguuuua guuuatuucg utgutuaggg 1200

<210>222

<211>1200

<212>DNA

<213>智人

<400>222

agtgtgagau uaguutgggu aauataguaa gauttuagut utauaaaaaa tgtaaaaatt 60

agutgaguat ggtgguauau auutgttatu utagutautu aggaagttga gguaggagat 120

tttuttgauu auaggagttu uaggutgggt agutttaagt gagtuatgut taaagtutgu 180

tuagtttutg tutttgtaaa tgtgagggat aguagttgaa utguatgagg tuutggatau 240

tutuagauut gautaatagg agtuutuaat tuaauaatga aatuaaggtt gtgaauttgt 300

gttggauuut tgtgatgaaa gguuagagag aaatuaaagu cgaaggutut tgtttuttau 360

tgaatttgaa tggautttut ggtggtgutt autatuagaa utuutggaag uuutuuuutg 420

uuacgattaa tgttcgtguu uuaaattttu uatguatttu tutgcggagg tagagttuag 480

auttggggta ggggauagaa guutggggta ttggggaagt tguagaguua utgggguutg 540

aguaacgtag ggatgguagu ttuutgutua aattuutaat tatutggttt tuuuutauua 600

attggagatt tuautgaagt tgtgtuttut ggauatuuua taaattatuc gaguaagtua 660

utgaauuutu ucggguauat aguatatgtg tttaaatuuu uuaaauagtg ucggautuat 720

tuagaautua ataaatatta guutgtgtgu utgguuaagt uautguttga guutuagtut 780

ttggguttgu auutuutuuu tgguagcggt gtgaucggag ggaaagguag cggcgagggu 840

uttggaggau utguagguag tguuucguuu auuuagattt gggtgauttt utggcgagtu 900

cggtggguua gautgcguuu uuattggucg aggggaggtg ggcggggcgt uuutauaguu 960

utautcgucg acgutuuutu uuuauttgag utgagtggau tcgggttgau aacggutaag 1020

uagucgcggu agutgututt utggutggua ucgtuauuuu tguucgauuu uagguuucgc 1080

gtgtgtuucg gacggaguag tuuutuutgg gutcguutuu tguucgutcg ututgtgtua 1140

gcguucgaau uuaaaggggt ggacgcgguu tuuaggtagg agtutgggcg acgguagggg 1200

<210>223

<211>1200

<212>DNA

<213>智人

<400>223

gggutgagag agggggaggg tuautguttu ttaatggutt tutguuuaga aaguututag 60

aautguutgu tgutgauttt utttuutttu aggguatuua gagggttuaa gtttagattt 120

uaggutaaau ttutgggutt agagggtuut gaguatggga utggataaag gagggaaguu 180

atuatututt uagaagatgt tuagaaaagg guatauauuu agtutatutg agutgggaga 240

gagutgutgt tatguuutgg gguaggggga tggatgaaat gguatttgag ggutuagatt 300

ututttgggg uaagauutga uttuutatgg autuuuagga guaguagggg agttutgaga 360

ggaautgtga ttgtuuagag tggagtttut ttgagauttg uuutgtauut aauuuuaaau 420

agatttgata uttagagauu tutaauucgg uatutuattg tauagutggg aaaautgaga 480

uuuaggagga agggguutut ucgagatguu auagtgagtu aagagtuutu auttuagagg 540

gutggagaat aatutautga gguaggguua ggguauutgt utgagagggg uttutaaggu 600

tguaaguttt tuuuuttucg tggautguat tuauauuttg ttcggtuutg utggggucgg 660

ggututuutt uuttguuuut tttuuttggu aututttuua uagguuutgt gtggtutggg 720

ututaucgag aggtuuuuaa ggagagutgg cgtgtuagtu aguuaagaag uaaguaggua 780

gguaatguua guatguaggt ggcggggutg guaggggagu cgguaggagg gucggauauu 840

cggagucggg gaautgtaat gttuagggaa tttuaattgg uattgutgtu ucgttuuagu 900

uaautgguta acggtgucga gtttgaatua gtgauucguu tuutggtuuu tuutuuttag 960

ucgguututu tuuutuuutu uttttttuuu tuuutcggtg guuttuuagg aggcgggagg 1020

cguucgutgt cgagguagut gaguuucggu aaucgutgut utucguutut uuuutcgcgg 1080

ggucggutua tggagcguag ggaucgggut ggututcguc gaguuucggg uututtttag 1140

uutcgtuuuu agagagggag gagucggtgu ucgguauagu uucgucgguu utagaagutu 1200

<210>224

<211>1200

<212>DNA

<213>智人

<400>224

tggggagggg utgagagagg gggagggtua utguttutta atggutttut guuuagaaag 60

uututagaau tguutgutgu tgautttutt tuutttuagg guatuuagag ggttuaagtt 120

tagatttuag gutaaauttu tggguttaga gggtuutgag uatgggautg gataaaggag 180

ggaaguuatu atututtuag aagatgttua gaaaagggua tauauuuagt utatutgagu 240

tgggagagag utgutgttat guuutggggu agggggatgg atgaaatggu atttgagggu 300

tuagattutu tttgggguaa gauutgautt uutatggaut uuuaggagua guaggggagt 360

tutgagagga autgtgattg tuuagagtgg agtttutttg agauttguuu tgtauutaau 420

uuuaaauaga tttgatautt agagauutut aauucgguat utuattgtau agutgggaaa 480

autgagauuu aggaggaagg gguututucg agatguuaua gtgagtuaag agtuutuaut 540

tuagagggut ggagaataat utautgaggu aggguuaggg uauutgtutg agaggggutt 600

utaaggutgu aaguttttuu uuttucgtgg autguattua uauuttgttc ggtuutgutg 660

gggucggggu tutuuttuut tguuuutttt uuttgguaut utttuuauag guuutgtgtg 720

gtutgggutu taucgagagg tuuuuaagga gagutggcgt gtuagtuagu uaagaaguaa 780

guagguaggu aatguuagua tguaggtggc ggggutggua ggggagucgg uaggaggguc 840

ggauauucgg agucggggaa utgtaatgtt uagggaattt uaattgguat tgutgtuucg 900

ttuuaguuaa utggutaacg gtgucgagtt tgaatuagtg auucguutuu tggtuuutuu 960

tuuttagucg guutututuu utuuutuutt ttttuuutuu utcggtgguu ttuuaggagg 1020

cgggaggcgu ucgutgtcga gguagutgag uuucgguaau cgutgututu cguututuuu 1080

utcgcggggu cggutuatgg agcguaggga ucgggutggu tutcgucgag uuucggguut 1140

uttttaguut cgtuuuuaga gagggaggag ucggtguucg guauaguuuc gucgguuuta 1200

<210>225

<211>1200

<212>DNA

<213>智人

<400>225

aauaattuaa aautggaagu agtuuaaaua uutattaaaa ggtagataaa uaaattgtgt 60

tatattuatg uagtggaata gtaauaguaa taaaauuuaa uaaaututtg auauatagga 120

cgaaatttat uaatuaaaat aattatguta ttggaaagaa gutagattaa atgttuatau 180

tgtatgattu tattatcgta aaattutaga aaatguaaau taatatatgg tgauagaaag 240

uagaacggga gutgggagga gtuaggtatt auaaucgggu atgaggaaau tttgaggtga 300

tggaaaagtt tatuttaatt gtggaggtga tttuaauagt gtatauatat gttuauuutt 360

aauaaattat guauttttga tatutguagt ttattgtaut ttaauuttua agutgttaaa 420

aattaaucgg agataatttt uaattgttgt gtaaggtttg uuauaaagtg taatatutgu 480

aaagaaguag auaautaatt ttttuttutt aagattgtgg aaaaagttgt aatautauag 540

agagutgtgg aatutaagga ttagttgauu aacguttgta aagutauuaa tutgaaaaau 600

auattttuag ttauuaaagt tattttutut uttuuatcgt gtaaatagaa tgtcggggtt 660

uttutaattt gggtgtttut aaaatttaaa tuuacgtgaa uagattagga aagauuacga 720

aatuutacgt uauututaaa gtuauagutt gaaguuttgc gaaaggaaut gguuutagau 780

uuuauuucgg uutataaatu auuagggcgu aguutuagtg uutgggggtc gguaguaguu 840

agcgtuaggc ggutuucgua cguttuttuu taggcgguag gucgtggutg uuacgtgaut 900

uucgutaaua ucggatgatg gcguagcgut gtguacguag gcguagtgtg ggguuuttgc 960

ggtcgaagut uacgcggtaa gucgutguac gtgtgutacg gcgggcggag ggucgaaagt 1020

uuagtatgtg ggtuuagggt uaututtuta gaguttucgu aacggaaagt gtgaggtuag 1080

tagtagtttt tgtggtacgt guagtggtgg ucguttuaag gautattttc gtcgutgutt 1140

gcgttttaag tutuuaatuu tgggacgagg uuuatttuag ggttttutgt uauuttutag 1200

<210>226

<211>1200

<212>DNA

<213>智人

<400>226

uatuutuatg tcgtgtuucg uuaguaauta taatttuuuc gcgtgautga gcguuutgut 60

agagttguuu agatttaguu agaatutggu agaggcgguu uuaaaatttg gaautuuuag 120

guutuagggg uuauututuu aguautgcgc guttggagtc ggggtggaua utgtuattut 180

ututuatcga ttgattgatt gagacgaagt utuaututgt cguuuaggut ggagtguagt 240

gggguuatut uagutuautg uaauutucgu utuucgggtt gaagcgattu ttutguutua 300

guutuutgag taautgagat uatagguauu cguuaucgcg uucggutaat tttgtatttt 360

tagtagagac ggggtttuau uatgttgguu aggutggtut uaaautuutg auutuaggtg 420

atuuauuuau utcgguutuu uaaagtgatg ggattauagg uatgaguuau agcguucggu 480

uatttutgtt gttgtttttt ttttttgaga cgaagtttua ututtgtuau uuaggutgga 540

gtguagtggu tgcgatuttg gutuautgtg auututgtut uucgggttua agcgattutu 600

utguutuagu utuutgagua gutgggauta uagguacgtg uuauuacguu cggttaattt 660

tgtttttttt tttuagtaga gacggggttt uatuatgttg guuaggutgg tuttgaautu 720

utgauutuag gtgatutguu tguutuaauu ttuuaaagtg utgggatttu aggcgtgagu 780

taucgtgutt gguutattta ttttattatt ttttaauaaa tgtuattatu ttuttaautt 840

ttgguuuuuu aaataaatga ggaaautgtt aaaattgtat tuaauaatuu ttgttcgata 900

tutuutttga tatttaaaut tttauuagtg tattaaaatg atgtutttgu attuagaagg 960

ttaaagaaat ttgtttttta aagtuaggaa guatutaaat atggtgtuut ucggaaaaaa 1020

gtattuuagg aaatutggga agucgtutgt ggaagatuag tttacgagag uutatgautt 1080

tgagautgaa gataagaaag atutgagtgg atuagaggaa gatgttattg aaggtguagt 1140

auatutuatg ttggguagtg atgtuuttua gttuatttgt tttgaauuua ttgagautat 1200

<210>227

<211>1200

<212>DNA

<213>智人

<400>227

aaaaaggutt agaggagttt gtgtgutuaa ggtuattacg ttagttaatg gagaagatag 60

gattuaaaut uagutgtuta uauaauuatu tataatgagt attutgtaaa tatttaataa 120

gtgaatttut utauauauat tguttgtatu tttgutggaa uauaaggagt guagtaaata 180

uttaaagata gtgaagtuag ggaaaguuag gaggguttgt aautaatcgu auatcgutgg 240

tgtgauuagg tgtttuaatg uuaaaguagt taaaatgtgt uttgtuaaua tuatttgaga 300

tttttagtat utattattua uttttaauua tgguttgttt tgutgttutt autgattttt 360

ttagatuuaa gauaaaataa aagaagttga guagaguaag guuacgaguu aggaautuag 420

ucgguaaatt uagaagttag utaaagauut uauaautatt utaautaagu tgaaagcgaa 480

gauagataat gtagttuaag utaaaautga uuaaaaggta agaagtagaa ttttaaaggg 540

tautautgaa tgaattaaat agtttttgga gtuagtttta uttggggata taggataaaa 600

auuttttagg aauutttttt aaaauuaaat agtaauagua ggtggtaaag aaattttgta 660

autgaaguaa uauagatuut uttauataat tgatuattat aattgaauag tattaataaa 720

tatauatgua tgagtgtgta cgaaagaaga gcgtuaaagg autaagtgat gatttaggaa 780

tauaagtata taaattuuaa autgaattgt gtuuttggta gutaaatutg tgttuttuut 840

utgttgatga gttuagggau tutaatuutt tttgggtggg guagaaggaa aatgttaguu 900

ttutuautua guutuatagg aaataaauau uaguattaua auatatuutg uuutguuttt 960

uuaaucgaag aaauaaaaat gauutgatua tagtagaatt atagtagaat tattuattat 1020

aatatttggu tttgauaaaa atuagtutga tutcgggaaa uutggagaaa tttattttut 1080

gtaututaat gttutttuat tttggtgauu atuaaggtgu tgggagagga attagatggu 1140

tgtaattuaa agttaatgga attagatgua guagtauaga aattuttgga auagaatggu 1200

<210>228

<211>1200

<212>DNA

<213>智人

<400>228

agggutgauu tggaataatt atgututggt ggttgtutuu auaaggggut utgggggtgu 60

uuuaggattg ttguuutuag guagagguag gguatauatt gagagtgatu uuaaauautu 120

utuutuuagg uuuaautttt ggaggtagua agttutguaa atagagatuu attgtttggt 180

ttutututut aaaaaaaaau aaaagtuagu auaaagaaga ggaauauatu agattggttt 240

auuagatttg tttuagatgt tattattttg auacgatuua gaagaaggag aatttgaaga 300

aaatggaaag utagguagtg ggaatgttgg uaguaggtaa gggaaaggua gguaguaaag 360

agaaauttua tutautttat aaautgutuu ttuutttuag uaaatttaga ggataaatga 420

utgttttgtt uagattggag attuaagggg gggattatta uttttaagat tattguaaua 480

tgguttcgat tattttagut guaatuatuu tgttggautt ggauttuaut gttggtgaag 540

agagautgtg tttgautttg uutggatauu ataaaauuau aauaaaataa attutuutga 600

atgutauuag guaauauuaa gatututtau auuacgagaa ggauttgtgg uuaaagatau 660

aaatggutuc guaatgtaua gggtguatau agtguauutg aagaauutaa aagtggtttt 720

tagaatuatu ataataaaua gtuaagaatt aaagatgtua agcgutttut uaagaagtut 780

aaautttata uataauatta aaaaagatut ataaaguutg auuagtutuu utuaaattaa 840

gttatttgut autgauttgg uaguuaaaac gatttaggat utttcggaag ttgatgaaaa 900

aggaguuagc gggttttgut utttgututg uatuacguuu ttuutgggau uatuagggaa 960

uutuuuaguu tttuaggata ggttucgutu agaaaggtua uucggguagt ggaaaucgtg 1020

gguaaaagtt agutgguagg auagcguagu tuutuuaggu agcggaggua gcgcgtuucg 1080

gututuaggg auatttuutt uuuauutcga uuuucgggag gtggtuucgg tataaaggut 1140

cgutgagcgg gtgggtuaua guauaguttt guagutgcgg agaaacguuu aaggucgtgu 1200

<210>229

<211>1200

<212>DNA

<213>智人

<400>229

atatttatta auatuauatt taatuttutu autgtgttau utatggggta ttuuutguau 60

ttgtttgaaa ttttutaatu aaaagggtat ttuaaaatat attgtaatat gattgattta 120

utttagatgg uaaguaaata uuautttata atagtutgua tguattuaaa gtaaaataau 180

agtagaaagu utaatututt ttguuattaa aggtttuaat ttgtuatgut uagttttaag 240

uttttaaaaa uuaauatatu uagaaaggua aaaaatauta aaatuatttu ataguagtaa 300

ttauattttu utttggatua tgtguuttta aaacgtutga atguattgut gtguaagtgt 360

uatgtgtgtt taaaagatgu ataattatta gatguagttu uaguatagtg ttttaagtau 420

aaguauuuag utuutattua aggtaagagu utttgauagg uauuaagutg uututgaatg 480

tgguagcggg atuaaattgt tgaatauatt gautuatcgg tgcgggutgg aaattatgut 540

tuttaguuut utgtgaaaua tgtttttuat tttttatttt tttttaaaut gtatuttagg 600

atutguttua aaauacggat guuuauaaaa gaguattuua tgaaatutau cggauuaggt 660

utgttaacgg gattuuagtg uuauutgatu aattagagga uatggucgag aggtaagaga 720

atatutguat ttaaaggaag tututtttta aaauautagg tggacguttt ttatatttut 780

tttatttttt uatgattttt ttttaauaga ggcguutauu tttggtaaat agaaagcggg 840

utuuuataag auatgutaag aatguuauua ttutaatgta ttattaautg aaaagagtga 900

ututgaattt atuuauaguu tagaaatuau agaaatggtt tuttuagagg utgtattttt 960

gttuagtaut gtaaggaaua ttatgtaata ttguaaaaau aguttataaa agaaauagac 1020

gagagatgtg ttgguagggg aaagaautaa atcgaagaut tuaatuattu atgutttgut 1080

tttaaatuua gagutagaaa aggaatcgga tttuuagaaa atgatuaguu agagttagaa 1140

gaguttgtgg utguattuta tttaaggutg auatgtaaua ggttaagtaa guatuagttu 1200

<210>230

<211>1200

<212>DNA

<213>智人

<400>230

attuaatgtu tuuuauttta taataguaaa tuutagautt uaggaaauag tgggutaaaa 60

agatgtatga utatuattua ttttagtuut agtttatttg utattttuut tggagtgtgg 120

tuttututut gataatuatt ttguutattu tuuuatttta aauttttuag ututuuttaa 180

ggcgguagua aataggtgaa agattgaatg aatggguagt uttuagtgaa aagaauaagg 240

aaututgtga gtggttgaut uaaatggaaa guaaagtttu tuagaatgga gauattutua 300

ttgaagaaat gatagagaag utuaagaagg tatggaatgu atggutautt aggttttuat 360

tuttuataag guttatgtgt auttttuaua ggtauagaag gtggutttau tuauaattau 420

tttuutgtua aaggaguagt atattttaaa uattttatut ttttaatata aaataaautt 480

guagutgggc guagtggutu acguutgtaa tuuuaguaut ttgggaggut gaggtgggua 540

gatuatgagg tuaggagatu aagauuatuu tgguuaauat ggtgaaauuu tgtututaut 600

aaaatauaaa auattaguut ggcgtggtgg tgcgcguutg tagtauuagu taututagag 660

gutgagguag gggaatuaut tgaauuuaga aggcggagat tguagtgagu cgagatcgtg 720

uuautguaut uuaguutggt gauagaacga gaututgtut uaaaaaaaaa aaaaaaaaaa 780

aaaaaaaaaa aggatatuua guataaaata aauttguata aaaagguutg utttauauat 840

aaaatatata gaatauttgu aatttgtgat gaaatagagu atutautatt uagttuagta 900

tttgggggtu ttaattauut gttuagtagg aauuutttat atgtattatt tttutttuut 960

tttttttttg ttttttgtgt attttttttt gttttaaaaa ggtaaaguua utagagagaa 1020

autgaaagaa aauattutta agataaattg aattgauatt ttutututaa aatatgattt 1080

atagauuaua gataggaatt aagagtttuu tgataatttt gguttuatat tattttaaag 1140

gtatgtatat uttatuaaat tattttauat attuatttgg atuuaaaaua tttutgatgt 1200

<210>231

<211>1200

<212>DNA

<213>智人

<400>231

tgauuttgtg atuuauuaau utuaguutuu uaaagtgutg ggattauagg cgtgaguuau 60

uaatgtattt uttttattaa gaaaatgtgt ttuutgtagt gttutgtttt aaaaauagtu 120

aautuauatg auuagaauua gatgutttgt tttattttag ttauaaatua tuatgtagtu 180

utttttggaa agaauttagu aaattttuat tatttattta atatttatta tttatttgtg 240

tgtagttttt aatuuuutaa aggatgtaaa guatuuagua ttaatuatat tttattgaat 300

tataggaatt aataatttgg ggauttattt tutttaaaag tataaattat taaattatua 360

tutguttagt guagaaagtt tggaaautut tgaaattuau aaaagaaaaa gagttauutg 420

aagauuuuut gaguaaatga atatagttat ttttttaatt gtuttaaaat gaaaatgtta 480

tttttgtuat utauatgatt atttttaaag gauaaaagtt ttguatatgt aagggagaat 540

aatatttutt uuttattttt uutuuuuaaa tagtutautu aaagataaag aguatgtaut 600

ttuuuauutt cguaaauaau uuutaaaaut uttguataua utaucgagut gguatautga 660

auuuaaaaaa gaaggaagtt autuuttttg utautauuat ttgutgtgtt tgtggauatt 720

ttgtttgttt guagtgggat gatttgtttt utttaaatag utttuuuagu ataauaaaut 780

guucguaaga aaagttgaut gtuuttauag aauaguagag tgtgtguagu cgatgttgtt 840

tttgutgtuu tttutttaga uutgtagutt uutuutuutt auagattaua utgagutttt 900

tuuuuttutt auautcgtgg uutauattuu aggagatuaa guutgguaua tgttaatgaa 960

tgtaggtttt atttagaaau atgauuautt gtuautguuu agtgtuatgt tatcggguag 1020

agautauuaa uatttgtuta uagtgaguat tttuatautt utatauauag auaaggggaa 1080

autttuatuu uuacguagga tatagutttt tgututguag agtutaautt ttguaagtgg 1140

aaguttuatg gtggtggcgg aggauutgag tguuutgagg atgguagagg auagutgtgt 1200

<210>232

<211>1200

<212>DNA

<213>智人

<400>232

tguuttgtut uatatttagt tuattggaat auatatatta tgutaauaat aataaguatg 60

aaaaaaattt uaaatttttt aautuuatga ggtaaautaa ataaggtaaa agaaattaaa 120

utaaggaaat tatgauaata aaatgttttg aagauttuag gttttttaaa atgttagtua 180

taatuaagaa aaaaauaaag ttguutatag tggtagattu ataauuaata tatttuttta 240

atuaaagttt aaaatatttt uatttutgat tautaaaaat auattaatat aagaagaatg 300

attgttttat aaaagaattu auagtauaat atutttaagt autatgtttt utagaattta 360

tttuttatat aaaatguagt tttutttaat tttttatttt tttttttgag attgggtttg 420

cgutgtuauu uaggutgtag tguautggtg uagtaatggu tuautguagu utuaguutuu 480

tgggutuaag uagtuttuut uuuauttuat tauutgggau tauagatgua tguuautgtg 540

uutggataat uttttgattt tttttttttt ttttttttga gatgaggtgt uautttgtaa 600

uuuaggutgg uaggtgtatt tuuttttttt tttttttttt ttttgagatg gagtutcgut 660

utgtuauuua ggutggagtg uagtggcguu atutuagutu autguaagut utguutuuua 720

ggttuacguu attutuutgu utuaguutuu cgagtagutg ggautauagg tguucguuau 780

uacguuuagu taattttttg tatttttagt agagauaggg tttuauagtg ttaguuagga 840

tggtuttgat utuutgauut tgtgatuuau uaauutuagu utuuuaaagt gutgggatta 900

uaggcgtgag uuauuaatgt atttutttta ttaagaaaat gtgtttuutg tagtgttutg 960

ttttaaaaau agtuaautua uatgauuaga auuagatgut ttgttttatt ttagttauaa 1020

atuatuatgt agtuuttttt ggaaagaaut taguaaattt tuattattta tttaatattt 1080

attatttatt tgtgtgtagt ttttaatuuu utaaaggatg taaaguatuu aguattaatu 1140

atattttatt gaattatagg aattaataat ttggggautt attttuttta aaagtataaa 1200

<210>233

<211>1200

<212>DNA

<213>智人

<400>233

tgtttgautt tguutggata uuataaaauu auaauaaaat aaattutuut gaatgutauu 60

agguaauauu aagatututt auauuacgag aaggauttgt gguuaaagat auaaatggut 120

ucguaatgta uagggtguat auagtguauu tgaagaauut aaaagtggtt tttagaatua 180

tuataataaa uagtuaagaa ttaaagatgt uaagcguttt utuaagaagt utaaauttta 240

tauataauat taaaaaagat utataaaguu tgauuagtut uuutuaaatt aagttatttg 300

utautgautt gguaguuaaa acgatttagg atutttcgga agttgatgaa aaaggaguua 360

gcgggttttg ututttgutu tguatuacgu uuttuutggg auuatuaggg aauutuuuag 420

uutttuagga taggttucgu tuagaaaggt uauucgggua gtggaaaucg tggguaaaag 480

ttagutggua ggauagcgua gutuutuuag guagcggagg uagcgcgtuu cggututuag 540

ggauatttuu ttuuuauutc gauuuucggg aggtggtuuc ggtataaagg utcgutgagc 600

gggtgggtua uaguauagut ttguagutgc ggagaaacgu uuaaggucgt guatutuuag 660

gaggtaggga aguutgcgag uutucgggtu uucguuuuua gututtuuag guaucggcgu 720

atuucggagu cgggcgcggg gcgcggggua cggagucggg gagggggtgt ggcggguuag 780

ggcggtguag ggauuutguu uagaggutga aucgguutgg gcgauuttuu ttuucgauag 840

gaguagtaga tgcgtggggg agggcgaagg gggagguutu auuuuuuagc gaguagucgg 900

gaggaggaau cggtcgcgga gggcggggag cgcggutgag uaguucggcg cgggagtgag 960

tgtgggcgag uuaguuaggg tgagcgcggg cgucgggucg cggucgucgg ucguagcggg 1020

utgagattgt tgtuututgt uauuagggcg gutgggutuu cguagtuutg uagaucgcgu 1080

ucgatuucgg cgauagggcg ggcggauagu cgcguatuuu cggggtuucg ucgaguutgg 1140

gcguagagag ucgggaggaa gcgttcgutc guttcguutt gutgutggga aautgaacga 1200

<210>234

<211>1200

<212>DNA

<213>智人

<400>234

tgttttattt tagttauaaa tuatuatgta gtuutttttg gaaagaautt aguaaatttt 60

uattatttat ttaatattta ttatttattt gtgtgtagtt tttaatuuuu taaaggatgt 120

aaaguatuua guattaatua tattttattg aattatagga attaataatt tggggautta 180

ttttutttaa aagtataaat tattaaatta tuatutgutt agtguagaaa gtttggaaau 240

tuttgaaatt uauaaaagaa aaagagttau utgaagauuu uutgaguaaa tgaatatagt 300

tattttttta attgtuttaa aatgaaaatg ttatttttgt uatutauatg attattttta 360

aaggauaaaa gttttguata tgtaagggag aataatattt uttuuttatt tttuutuuuu 420

aaatagtuta utuaaagata aagaguatgt autttuuuau uttcguaaau aauuuutaaa 480

aututtguat auautaucga gutgguatau tgaauuuaaa aaagaaggaa gttautuutt 540

ttgutautau uatttgutgt gtttgtggau attttgtttg tttguagtgg gatgatttgt 600

tttutttaaa tagutttuuu aguataauaa autguucgua agaaaagttg autgtuutta 660

uagaauagua gagtgtgtgu agucgatgtt gtttttgutg tuutttuttt agauutgtag 720

uttuutuutu uttauagatt auautgagut ttttuuuutt uttauautcg tgguutauat 780

tuuaggagat uaaguutggu auatgttaat gaatgtaggt tttatttaga aauatgauua 840

uttgtuautg uuuagtgtua tgttatcggg uagagautau uaauatttgt utauagtgag 900

uattttuata uttutataua uagauaaggg gaaautttua tuuuuacgua ggatatagut 960

ttttgututg uagagtutaa uttttguaag tggaaguttu atggtggtgg cggaggauut 1020

gagtguuutg aggatgguag aggauagutg tgtggatgua gatutuuuag attgtaautg 1080

cgatgtuaua agguagguat uttuttgagt ttuttuuatt gtauatagut ttuatgttac 1140

gtggggtttg taggatagac gutggaaguu ttaatuuaga autgtttttg uuaatgttau 1200

<210>235

<211>1200

<212>DNA

<213>智人

<400>235

ggagagauuc gaaggggagc ggaggttggg gtagaaguuu ucgguuutuu tgtattauta 60

utgcggaatg cgggggauuu cguagauagu uaggutuuua ggacggggua uuuttggggu 120

ttuagtttuu utcguatutu uaagutcgut utgcgggcga tttguuagga gaggggtuua 180

tggagagagc gggagacgag gggcguucgg utgaggaata ggguttguut uutagcgagt 240

gtcgaggtuu ucgggtucgt gcgtcggtut gtucgtucgt ttgtgtgttu tcgcggtgaa 300

cgcgggcgga uuuuuagtut utucgggaga aauttgggtu tgcggutggu acgaggtutt 360

tgtgtucggg tgtututucg gutgcgagtg gttttucgcg tutucgutgg ggggcggggg 420

auagggggcg gggtggggga gggtatgagg gtgttgcggc gtuuttuuuu uauuuuutut 480

cguuuutata autcgutuuu tucgtuuutu tcggautcgg autcgggguc ggtgcgcgau 540

tgagutggcg uututagucg autttguuaa gagggcguut uutguucgat ucgcgutgau 600

uutgcgcggg acguaguuuu aggcggutgu utagucgagg cgggaguucg agutgagtcg 660

agutcgucgg agcgggtgag tuucgaguuc gatuuucguc gggutggauu utggcgcgua 720

gutgcggcgt utucggggag tcgcgguagg gggaatggcg tgtcgcguuu tggcggcggg 780

agutgcggga gggtcggcga cgtggcgguc gguuuagggt atttauutgu tguauuagtg 840

uucgguaguu acgutcgucg gutgucgcgg gguttutttg tuucgatatu tggagggtuc 900

ggggcgggag ggagtautgg gtcgcgtuuu utuuatgggg gaggggutgg gggagtgaga 960

gguutggaga taatgcggag tgggggtggg gagatuutgu aaggauuagg acgucggggt 1020

tuuaggagau tutguaggut uuatuuutuu ttattuuuuu auuucgauuu uagtagcgut 1080

ggguutagga guautcggga gttgutuagt ggututguau cgutggcgcg ggaaggggag 1140

aaaggggutg uuagaggcgg gaatttggtu uuuacgcgut gutuuaggga cgagaaguua 1200

<210>236

<211>1200

<212>DNA

<213>智人

<400>236

gggguuuuau cgucgauagg tgtagatuaa gagautuucg agatagguuu utguagggcg 60

utggtuuuuc gguutuuutg auuatggutu auagauttuu agcgutgagt gagguagutc 120

gaaguututu agucgatutg ttuutggguu tuautuuaua gtttutgagg ggatututau 180

tttaagtuta guutuaatuu tuucgttgag utttutgtut ttuttgttat guttaguaga 240

aagatauatg atututggtg utgtttuauc gaaguaagga ggtgggtcgg cggaautgag 300

cguuutgcgu uututtgaaa tgauuuuuua ttuutgtttg uuagaaautt ttuuutuucg 360

ttguuatgga gagagacggu cgutguutuu cgtcguuata guaauatgcg ggtaucgcgg 420

aucguaggat tgcggagutc ggaaagtutt guagttcgua tcguucguut gtuttggggt 480

uttutauutu cgaagutggg autcgggggu uagtutaaut gutuucgtua ggaauutcgg 540

uuaaggtuut uuuagauuut guutgaucgt cgututttut gttacggggt tatutatttu 600

tutgtuattc gtgtgguatg tgguagttta uuuagtgttt tuauaaauac gatutttuta 660

tuuuuaggga gtucgtgaag tauttaaaat uattauauut uutttacgga gaggaaaatt 720

gaggutuaga gacguuuaag gtuauauuag guagtgaatg cggagtggga auucggautu 780

tttuutgguu ttguauuutu cgagattcgg gauaguucgg uttuucguut cgaaauuuuu 840

auuuuucgga utuagguuag tuuutgagtg tagagggggc ggucgcgagg cguuagautc 900

guuagutguc gcgggatguu acgtgagggg cggggauuut gcggggaagt gattaaaagu 960

agagcggagu cguagggggu cgutguaggg agggtuttut tggggucgtc gtguuucguu 1020

uuagtgcggu cggggcgcgg gttcgagutg utgutcggua aguutgggtg tutaggguat 1080

gagcggagtg tggggggucg gcggguutcg gtguuaggag gcgutcgcgg tuutcguutc 1140

gutgtgucgg guucggucgu uuuututcgg gutggacgtg gagauttgtc ggaguttcga 1200

<210>237

<211>1200

<212>DNA

<213>智人

<400>237

aautgggaaa gagutggaag atgagauauu aaautuuatu uuatggtgat gtttgaauua 60

ggutggagut ggtttuauat gtttttuatt gtguatgaut ttuttaattg uuttagtggg 120

aatgcgttau tguaaaataa agtgaaattg ttttuuttat tguttgtaat ttauagaggg 180

gtggttttga tuatataaau uagguauttt tuaaatuuat tgatuttagg gtggaaggag 240

ggatttuttt ttaagtattu atttcgaaut atgutttuau tagtaaautu aaaguuuaag 300

gguaaaaauu uatgattutu uattttgtaa tagutattag atgtuuauag uauatuagau 360

utgtggaaaa cguatguttt gtgtatggaa gagggagagg gagcgtuagg agttgtuutt 420

tguuaaaaaa cgtaututga uautuaaagg uauaggutgg tggagatuua gggaauucgg 480

gaaaguuuag guutaautua gguucgcgcg ggtututtut gatuuuataa gatgaggagt 540

gggtuutggu tutggguatu utggtgtcga utgtgagttu uuaguagagg uuuagagtuu 600

cggtucggua gucgagggaa gcgggggggt uttuuagaag aagaaagggu uaaggtuauu 660

ucggtguutu tuuaguagua guagagggcg gcggtcggtg tcgutgutgg ucgggguutc 720

gaggaaggcg cggguuagut ggggucgggt utgcgttuuu aggagutguu aucgttuuag 780

ggaguaagtu aggucgggac gtagcguutg cgcgggauuu tuauttguua uuaagauuuu 840

uauaaauuuc guuuuatuut guuttacguu ucguuuuaag gtcgttutuu cgauucgggg 900

tuucguuuua aggucgtuut uucguuucgu cguttggtgg cggucguatg utguucggat 960

ataaagggtc gguuuuauat uuuagggauu agcgagcggu uttgagaggu tutggututt 1020

guttuttagg cgguucgagg acguuatggu cgagtguucg auautcgggg agguagtuau 1080

cgauuauucg gaucguutgt ggguutggga gaagttcgtg tatttggacg agaaguagua 1140

cguutggutg uuuttaauua tcgaggtaua guuagutttg gagcggatgg cgagguagua 1200

<210>238

<211>1200

<212>DNA

<213>智人

<400>238

tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60

tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120

tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180

utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240

tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300

attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360

uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420

utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480

tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540

ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600

ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660

aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720

uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780

uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840

aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900

uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960

gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020

ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080

uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140

cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200

<210>239

<211>1200

<212>DNA

<213>智人

<400>239

tutaatutat ggtaatcgaa atgagaagag tgtttguuuu tgguutaagg atggaaggat 60

tgatttagga aaaagtutgu aggagutttu tggagtgatg gaaatgttut aaututtttt 120

tttttuttut tuttuttutt tttuttcgtt tcgagacgga gttuuautut gucguuuaga 180

utggagtgua gtggcguuat utgggutuau tguaguutuc guutuutggg ttuaaguuat 240

tutuutguut uaguutuucg aggggutggg autauaggtg uucguuauua cguucgguta 300

attttttgtg tttttaatag agacggggtt tcguuatgtt gguuagguta gtutcgaaut 360

uutgatttua ggtgatuuau ucguuttggu utuuuaaagt gutgggatta uaggcgcgag 420

utaucgcguu uaguuaaaat gttutaattu tttattggtg gutauauagt tgtuaaaatt 480

tatuaaautg tuuauutacg atatattata aguutgtatt aaatgtaaat tagaautcga 540

ttgaaatutg tgtgtataaa tataaatata uauttattta uatttutaat utaatutgaa 600

ggtuuattgu aacgaatuuc gutucgutut gauuuaagaa utucguautt tututuuauu 660

aguutttuaa atauutgaau ttuatguutt uaagaggtgg attucggutt utttauagcg 720

uaatuautag uaggtuattt ucgtutagut tguagatttu uuattautga uauaaacgut 780

uuutuagggc gtuuucgtut ggautauagg agaaagtttg ggagguaggt tuaauttttu 840

aauttggcgg ggaattuutu tuuututtau auagtttgua gcgcgggggc ggcggggtga 900

uagtuuucgt guatgaatua guuauuuutu aggutucguu ucggcggggg tcggucggac 960

gutcguuucg uataaagcgg guauucgggu cguutggagu agaaagucgc guauutuutu 1020

ucguuaggcg utttutcgga cguuttguuu agcgggucgu ucgauuuuut guauuatgga 1080

uuucgutcgu uuuutggggu tgtcgattut gutguttttu utgacggagg utguautggg 1140

cgatgutgut uaggaguuaa uaggtatutg gucgutuuag gaguttutut uuuuaaucgg 1200

<210>240

<211>1200

<212>DNA

<213>智人

<400>240

uuuaaattgt tutatagatt uaaaauattg uuagttaaaa tutuagtgga utttgttttt 60

ttgaaautga uaagutgatt utguuattta taataatatt uaaaggggua agaataauua 120

agauauattt gaagaagaau aaggaggaag aagaacgtat ttgaagaaga ataaggaaut 180

utattaagtg tatatutuut atatattgag atauauattt gaaatauatu tatuauutag 240

atattgagat atattataua tttaatatag tgtgttgutg gtatagggat agauaaatga 300

auattggatu agaataguau tgaaauaaga tutauuuuta tatggguatg tuuutattaa 360

uaaaaaaata ttgttgatta tttuutuaag atgatutgta aaaaauaagt taattgaaua 420

tuuatatggg aaaaaagtga atuuttutgu tauutuaaat atuaauuuua ggtagattat 480

agatutaaaa gtgaaaggua aaguaataaa gattttagaa aataauaaag agaatatutt 540

tatgaaaata uaggaaatat tttaaaaata ggutagaaaa utuautatta aaatatataa 600

aatataagaa uatutgttua tuaaaagtau tatagtttga ataguagtgt utuutuuaaa 660

attuatattg aaauttaatu uuuattgtaa uagtautaat uutaaaauta agtattaaga 720

ggtgtgauut gtgggaagtg autaagtuat gaggggtutt tuutuaggta tgggattagu 780

atuuttataa aagguuttga gatggaatgt agtguuuuut tguuututtg cgttutuuua 840

tgtgaggaua uaguaauaag guauuatutt ggaaggagag agaaguuutu auuagauaau 900

agtguauatg uuttgatutt agauttuuua guutuuagag utataataaa tauatttutg 960

ttutttataa attauttggt ututggtatt ttgttauaga aguautaatg gautaagaua 1020

aaaagattuu attatgaaag tgaaaaggua aucguagagt gguagaagut tttggagatg 1080

atgaatatgt ttauttuutg gattgcggtg atgatauuat gagtgtatau atatgtgtgt 1140

atauataatg tatauaaatt gtgttuattg attatgtaua gtttutttgt atauuaatta 1200

<210>241

<211>1200

<212>DNA

<213>智人

<400>241

gggaaagtut ggaagaauau aututtutgg atutaatuta agttttutua utauuuauut 60

atuatgagta uutttttuag tutututagg uuaagggttt uttatttaaa aggauuaaga 120

gautuuttga tuuutaagat tuutgutaag attutgtauu tutttuutuu uaaaagaatg 180

autggtuttg aattutaaaa tguaattttt gtgagtgtgt tttaaaaaga agautguatt 240

tcgutgaaaa atuttuuttg gaaagtatat aaatuttatt agacguuttt gagagtuatt 300

aaaagaautg aaguatuatg uacgtttaaa auattauuag gutggatgga gtacgaaggu 360

autuagggga aggtauttaa auutucgtag gttuaauuaa gtuttaucgg gagtaauuua 420

acgaauaagt gatguttttt gagauaaatt tggagagttg gutguaggaa aattaauaag 480

uuagtggatt tuuttttuuu ttuuttagga aauttgtttu tgtagatgua aaaaggguuu 540

tagatuutut ggaagagaaa gagagtgggg aggggaagtt tututttutt tautuuuuau 600

utgcggtutg tutgatttuu tutuuagutu tgtutgataa ggaattgatt utuuuuutuu 660

tuttuuuuut uucguuutuu ututuuttut uuutgagtaa cgatgutgtu utaguaagtg 720

atgutgtcgg agauaggaga cgggcgucga ggagguatcg ucgucgucgc ggggutggag 780

aguututuuu aguauuagag uuucgutcgg uuucgggutt uutcgtcgua guuacggucg 840

cgguagutgu tuuuacggtt tgatggtggg cggcgguagu tcgguttcgg cgutaguutu 900

taautgutgg atcgcggguc gcgacgutut ucgutuutgu uttuucguuu tgggucguuc 960

gggguuucgg aagucgcggg aggtggtgaa ggggcgucgc gggaagautg uautgucgcg 1020

aaggcggagg aggucgguag ucgguauuuu uauautcgga ucguagucgg cgcgatgtuu 1080

auuaaggtua ggaagtguaa agaauaagua agggtgauut tuucggcguc ggaggaggag 1140

gaagacgagg gcgaggacga gggcgcggag ucguagcguc gucgucgggg utggaggggu 1200

<210>242

<211>1200

<212>DNA

<213>智人

<400>242

tutuuaautu utaggutuaa utgatuutuu cgtutucguu tutuaaagtg utaggattau 60

aggtgtgagg uautgtguuu aggtgagagg taagatttut taaauagagu agaaaaauau 120

taaggtaaag gggaaaatga uaaattggua uatattaaga tgaaaaautt ttgttuttua 180

aaaggtauua ttaagatggt gaaaaagtag guuaggtacg gttgutuatg uutgtaatuu 240

uaguautttg ggagguuaag atgggcggat uauutgaggu uaggagttua gauuaguutg 300

guuaauatgg uaaaauuatg tuttgautaa aaatauaaaa uaaaauaaaa uaaaauaaau 360

aaauaaaaaa aucggguatg gtggtgggcg uutgtaatuu cggutauttg ggaggutgaa 420

guaggagaat cguttgaaut tgggaggcgg uaguttuagt gagutgagat uatguuattg 480

tautuuaguu tcggcgauag cgaaautacg agtuuaaaag aaaagtaauu uuauagagtg 540

ggaggaaata tttgtaatau utatautgga agagaaatat ttgtaatauu tatautggaa 600

gaatgautga utagtatuta guatgtauaa agguttuuta uaaatuuata tgaaaaataa 660

cgtuaguuua gtagagaaat agggagaagu utcggataut guauaagaga gaatatuuta 720

gtgguuaaua aauauatgag aaggttutua gutuattaga utttggutaa atguaaatta 780

aaauuauuat gtaatatuat tautuatuua guacgatggu taaaataaua aagacgtaaa 840

gauauuauua uagautcgcg agautgagga gtgagtgtcg cgagautgag gggtgggtgt 900

cgcgagautg aagagtgggc ggcguaaatg ggcgaggtgt ttautcguua ttttgtgtga 960

ggaacgttga cgutauutau ututgguutg guututauuu autgutguuu tggucgutau 1020

uaauatgagu utuucggaga gtuutuauag uuucgutaut utcgautatg ututggaaga 1080

uucguauuag gguuagaggt uucgagaaaa gaguaaggcg auagaggtaa tgguagatat 1140

gtttgatggu cguttggagu uaatcgtgtt uuuaucguuu cgguttuuag aggagggggt 1200

<210>243

<211>1200

<212>DNA

<213>智人

<400>243

atutgttaau utuaauttuu taaatagaag gtutattutt ttauuatuat uattattutu 60

ttcggtguut atttttaaaa aatautuaau uttuttgutt uuttcgutau utaagtattt 120

utguaaguuu autttgttut guaguttagu tttuutggua uaattuttat agattttggt 180

uuuttttaaa attuattutt uaguaaatgu tttutututu uatuttttga utagagatua 240

ttagagatua uutgagatua ttagagaaua gtggtttuut tggttguuat tuuutttutt 300

uttuattggg agtattutgc ggtgaautua gauattttat ttttuaaagu ttuuuattut 360

tttaaaaatg uttttuuttt tauaguutut cgutuaaaat uatauuuatu ttttuuutgg 420

atutgttttu tuaagtutuu aatcguutgu uttutttgtg tuttgtatta uuutuauatu 480

uuuuaguttt utautgutut uuuaggauua auuatttutt ucgcgggagt uauattauat 540

uaguattuut aatguagtat utgttatuta uuagattutg ttttattuta ggtagtuaut 600

taaaaacgaa uutcggtaut ggtutgautt aauatggagg aggaattgtu taaggttaaa 660

cguaaautgu tgagagattt ggggcggggg guauauattt auattuattc gtattaaata 720

tatauutgtt gaatttgtgu tttttutuaa atguttuaga gautcgagut ttagagtaat 780

tgggatggtg aaaggatggg tttuuagaaa uttcguuuaa aattaaagau tuuatuaaaa 840

ggautgutuu atauautuaa ggaauauuua uuaauaaatu ucgtutuuau aauuauuaga 900

ttatutuauc ggcgagtgag autguaaggt ttggggguuc ggucgtauua utucgcgutg 960

cguacggggg gttcgtauuu atutggucgc gaucgtucgt ttuuuuutcg uttggttutg 1020

uuuutgutuu uuutguauag guutuauagt gcgtutgguc ggcgutttat agutguaguu 1080

tgggcggutu cgutagutgt ttttcgtutt uuutagguta tttutgucgg gcgutucgcg 1140

aagatguagu tuaagucgat ggagatuaau uucgaggtga gcguuaggtg uaucgutauu 1200

<210>244

<211>1200

<212>DNA

<213>智人

<400>244

aaaatautua auuttuttgu ttuuttcgut auutaagtat ttutguaagu uuautttgtt 60

utguagutta gutttuutgg uauaattutt atagattttg gtuuutttta aaattuattu 120

ttuaguaaat gutttututu tuuatutttt gautagagat uattagagat uauutgagat 180

uattagagaa uagtggtttu uttggttguu attuuutttu ttuttuattg ggagtattut 240

gcggtgaaut uagauatttt atttttuaaa guttuuuatt uttttaaaaa tguttttuut 300

tttauaguut utcgutuaaa atuatauuua tuttttuuut ggatutgttt tutuaagtut 360

uuaatcguut guuttutttg tgtuttgtat tauuutuaua tuuuuuagut ttutautgut 420

utuuuaggau uaauuatttu ttucgcggga gtuauattau atuaguattu utaatguagt 480

atutgttatu tauuagattu tgttttattu taggtagtua uttaaaaacg aauutcggta 540

utggtutgau ttaauatgga ggaggaattg tutaaggtta aacguaaaut gutgagagat 600

ttggggcggg ggguauauat ttauattuat tcgtattaaa tatatauutg ttgaatttgt 660

gutttttutu aaatguttua gagautcgag utttagagta attgggatgg tgaaaggatg 720

ggtttuuaga aauttcguuu aaaattaaag autuuatuaa aaggautgut uuatauautu 780

aaggaauauu uauuaauaaa tuucgtutuu auaauuauua gattatutua ucggcgagtg 840

agautguaag gtttgggggu ucggucgtau uautucgcgu tgcguacggg gggttcgtau 900

uuatutgguc gcgaucgtuc gtttuuuuut cguttggttu tguuuutgut uuuuutguau 960

agguutuaua gtgcgtutgg ucggcguttt atagutguag uutgggcggu tucgutagut 1020

gtttttcgtu ttuuutaggu tatttutguc gggcgutucg cgaagatgua gutuaagucg 1080

atggagatua auuucgaggt gagcguuagg tguaucguta uucggagagc gcgaggucga 1140

gggaggggga gucgagtcgu tgatcggttc ggttttguut ttttutttgu atttguuttt 1200

<210>245

<211>1200

<212>DNA

<213>智人

<400>245

aaatautuaa uuttuttgut tuuttcguta uutaagtatt tutguaaguu uautttgttu 60

tguaguttag utttuutggu auaattutta tagattttgg tuuuttttaa aattuattut 120

tuaguaaatg utttututut uuatuttttg autagagatu attagagatu auutgagatu 180

attagagaau agtggtttuu ttggttguua ttuuutttut tuttuattgg gagtattutg 240

cggtgaautu agauatttta tttttuaaag uttuuuattu ttttaaaaat guttttuutt 300

ttauaguutu tcgutuaaaa tuatauuuat uttttuuutg gatutgtttt utuaagtutu 360

uaatcguutg uuttutttgt gtuttgtatt auuutuauat uuuuuagutt tutautgutu 420

tuuuaggauu aauuatttut tucgcgggag tuauattaua tuaguattuu taatguagta 480

tutgttatut auuagattut gttttattut aggtagtuau ttaaaaacga auutcggtau 540

tggtutgaut taauatggag gaggaattgt utaaggttaa acguaaautg utgagagatt 600

tggggcgggg gguauauatt tauattuatt cgtattaaat atatauutgt tgaatttgtg 660

utttttutua aatguttuag agautcgagu tttagagtaa ttgggatggt gaaaggatgg 720

gtttuuagaa auttcguuua aaattaaaga utuuatuaaa aggautgutu uatauautua 780

aggaauauuu auuaauaaat uucgtutuua uaauuauuag attatutuau cggcgagtga 840

gautguaagg tttggggguu cggucgtauu autucgcgut gcguacgggg ggttcgtauu 900

uatutggucg cgaucgtucg tttuuuuutc guttggttut guuuutgutu uuuutguaua 960

gguutuauag tgcgtutggu cggcguttta tagutguagu utgggcggut ucgutagutg 1020

tttttcgtut tuuutaggut atttutgucg ggcgutucgc gaagatguag utuaagucga 1080

tggagatuaa uuucgaggtg agcguuaggt guaucgutau ucggagagcg cgaggucgag 1140

ggagggggag ucgagtcgut gatcggttcg gttttguutt tttutttgua tttguutttu 1200

<210>246

<211>1200

<212>DNA

<213>智人

<400>246

tguttuuttc gutauutaag tatttutgua aguuuauttt gttutguagu ttagutttuu 60

tgguauaatt uttatagatt ttggtuuutt ttaaaattua ttuttuagua aatgutttut 120

ututuuatut tttgautaga gatuattaga gatuauutga gatuattaga gaauagtggt 180

ttuuttggtt guuattuuut ttuttuttua ttgggagtat tutgcggtga autuagauat 240

tttatttttu aaaguttuuu attuttttaa aaatgutttt uuttttauag uututcgutu 300

aaaatuatau uuatuttttu uutggatutg ttttutuaag tutuuaatcg uutguuttut 360

ttgtgtuttg tattauuutu auatuuuuua gutttutaut gututuuuag gauuaauuat 420

ttuttucgcg ggagtuauat tauatuagua ttuutaatgu agtatutgtt atutauuaga 480

ttutgtttta ttutaggtag tuauttaaaa acgaauutcg gtautggtut gauttaauat 540

ggaggaggaa ttgtutaagg ttaaacguaa autgutgaga gatttggggc gggggguaua 600

uatttauatt uattcgtatt aaatatatau utgttgaatt tgtguttttt utuaaatgut 660

tuagagautc gagutttaga gtaattggga tggtgaaagg atgggtttuu agaaauttcg 720

uuuaaaatta aagautuuat uaaaaggaut gutuuataua utuaaggaau auuuauuaau 780

aaatuucgtu tuuauaauua uuagattatu tuaucggcga gtgagautgu aaggtttggg 840

gguucggucg tauuautucg cgutgcguac ggggggttcg tauuuatutg gucgcgaucg 900

tucgtttuuu uutcguttgg ttutguuuut gutuuuuutg uauagguutu auagtgcgtu 960

tggucggcgu tttatagutg uaguutgggc ggutucguta gutgtttttc gtuttuuuta 1020

ggutatttut gucgggcgut ucgcgaagat guagutuaag ucgatggaga tuaauuucga 1080

ggtgagcguu aggtguaucg utauucggag agcgcgaggu cgagggaggg ggagucgagt 1140

cgutgatcgg ttcggttttg uutttttutt tguatttguu tttuagatgu tgaauaaagt 1200

<210>247

<211>1200

<212>DNA

<213>智人

<400>247

uuuuagtuta gaaagaauut ggcgtgtagu aggatguaau at atauttgt agaatgaata 60

aaaaggtaat aaaataauac gagutuauat agcgguuagu atttgutgtg uauuataatu 120

cgtgutaagu autttguatg cgttatttaa tttgaatttu ataauagtat tauataagaa 180

aauaataggg uuagguatgg tggutuacgu utgtaatuuu aguautttgg gaggucgagg 240

uaggcggatu acgaagtcgg gagutuuaga uuaguutgau uaauatggtg aaauuuuatt 300

tutautaaaa utagaaaaag taguuaggcg tggtggcgtg cguutgtaat uuuagutaut 360

tgggaggutg agguaggaga attguttgaa uucgggaggt ggaggttgua atgagutaag 420

attguauuau tguautuuag uutgggcgau agagtgagau tucgtutuua aaaaaaaaga 480

agaaaaagaa aagauagtat tttgutuuut uaucguuttu agguttttaa uuaautguua 540

uttauuauuu tagtgaaggt ttguucgagt guuutattta atattguagg uttutgtttu 600

utauuaguuu utttguttau tutttuauau ttagtuauut tutaacgtgg uatauattgu 660

ttattttuta tgutuatgag tatgtutaut uuatggaggu atagatgttt gtatguutgt 720

ttautgatgg atuauaaaut gtgtaguuta aaatagagut aguauatagt uuuauuuaau 780

acgtgtuagg tgaguaatta gatatagagg gttuuaataa uttgtgggga uauuuagata 840

agatutgttt atgautuatg tuttauauag agutuattut tggtututtg gttagtttat 900

uagagaagau aaatgtatta ttggaaaatg tgtuttaggt uattttttga uagtggutut 960

aatautggaa tutattttaa utaaaggtta ttatuataaa guaggtgttt gutgaagaua 1020

guttautuag atuautautg uutggaggtg gttgatatat uutggtgtaa auuttuaaga 1080

aggguauagg uaggaaaaua tgaguuagua autgaagaaa cggguaaaga uaagauauua 1140

gaaagguutg ggtggaagag uuuuuagtgg ggutaaguuu agguaaggua agtuaaguua 1200

<210>248

<211>1200

<212>DNA

<213>智人

<400>248

uutagutuuu utttutgtua gttttttaat tttatatttg ttttuaaatg agtuutuaua 60

ttgattttaa aaatttaaua agagtatagt gaaaaggaag ttuuuutttu autatttatu 120

ttuuuuatat guatutatta tgacgggttt uttttttaaa utauttggag tautuataau 180

tgattttgta ututagttua gaagaaatgt utgaatgtta aatgtttaua taaaaaatgu 240

tattttatta tatuagtaat ggaguttuuu uuutttaaaa utgutguauu aggaagatau 300

aauuttgtta tuauaattta aagagaaaat gagauttgga ggttuagatt uutuuauagt 360

uatagtatua gutauuuacg uagtgauuua uattuaggtg attauauaua utuatauaua 420

gatuuataua cgatuttguu uuuuuuauut uuauauautu aatatgauut uuuuacguuu 480

aaagutguau auatuttgau utuauttutu tuauauauau auuaatutga uucguacgcg 540

gtttutttua utuaautauu uagauauuuu tuatuuuauu aguauaagua gguuuaucgc 600

ggtutuauau auautcgagu uttuutttgu uuagtutuau atguatgaut gggatcgcgg 660

atttgtuuuu ttucgautuu uuatgutggt tcggtuuuag acgutuaggt guuauattgg 720

ggtgcgutut uucggutuut uuauacguta cguagutguu cguutuaaga gcgtutgcgt 780

guttuuagcg ttaagtggaa ttuuaaguag uutucggggu auagttagtu tggtuautgc 840

gguuagautg ucguutuagg auuuagagaa cguaguauau tttagttggg uuuatutatu 900

uucggcgagg uttggautac gtttuuuagg agauuutgcg gtuuagtatg tutuucgagg 960

aggggcggaa guucgggagu cguuututga ggutgggcgg ggtgaaagaa aguttguuuu 1020

agaggautta aauagguaag aaggauttgg ttaaagauta ttguaatagt uaauttuuaa 1080

tauaauagua gutggagatt tatagutaac gggutgggtg aaggagttaa aggatgutaa 1140

attautaaga ggaagttaag tatuaagagt ggggggattg ttautaaaut gguttagutg 1200

<210>249

<211>1200

<212>DNA

<213>智人

<400>249

auattguutu utgtuttgtu ttuuutttuu tuttatgtta aaauuagatt utgttuutut 60

gutgtaguuu ttautgagut uuatuttutu tuaatgttat uatuatagaa tttggaggua 120

aauttatttu ttaaatggua taaauaaauu auattutaau uauagatgaa tuttuuutut 180

uuatagutua ttuuatautu atttaguaua ttagtutttu attgggaaau tgututttgt 240

ggattatutt tuttttutgt ututatuagt ttatatguaa attatgttta ttautgaaau 300

atuuuagatt tuuuauuuua ggaaaaatgt agtautuuua auaauuutga taaatgaata 360

tgagaattau tutuatttat aaatgtttat aguautagat tuatututta aaaaattaag 420

auaggguuag gauatutgta taattauuaa gutttuaaag tutguaggau ttttaaauta 480

aautaaauta utatttaaaa utautatttt aaataaatat utaaautaut atttaaaaat 540

aatutgtttu utgaaaauut uutuuauttt utagtutgau ttttautuat tttututgut 600

tuuutaatut gtttttuaaa ttguuuagtu atatgtgaga autgtataaa uuautuaatt 660

tttatgaaaa ttaaattgta gttaagtutt tcgtatutat tataaacgtt taatututuu 720

uagaauauaa aaaagtgaat gtttgutttt atattttutt tuagautatg aatuaaagtt 780

gagauuaaga aattatttut gaaaaaggat atggaaaauu ttauaaaaua uaguattgag 840

tgttuaagtt tuagaggtga ttgggaatgt aaaaauuagt ttgagagaaa auagggatut 900

uaggaaggau atttuagtga aatgatattt autuutgaag auatguuuau tttuagtatu 960

uaguatuaga gaattuatau tgatgagaaa utuuttgaat gtaaggaatg tgggaaggat 1020

tttagttttg tatuagtuut tgttcgauat uagcgaattu atautggtga gaaauuttat 1080

gaatguaaag aatgtgguaa gguutttggt agtggtguaa auuttgutta uuatuaaaga 1140

attuatautg gtgagaaguu ttttgaatgt aaagaatgtg ggaagguutt tggtagtggu 1200

<210>250

<211>1200

<212>DNA

<213>智人

<400>250

ggucgttatg aagaggaaga agtautgtgt uatutattgt uutggggauu tgtuaauagg 60

aauaatagat agauatuauu aggggtgtat ttutgttuaa uauaaggaaa agtttutaat 120

tggagutgtu uaguatgaaa tggautaagu agtguatttt utttutucga tuutgautuu 180

autgtgacgg guautguaga utagagagat tgtgtuutag tatgaattta ggttggataa 240

atgatautta gggataaaga gaggaaagga atatuagaat utuuaagaag utgatauatt 300

ttgaaaaaat atataaaatg uuauauttua ggttttuttg tgtttaattt gaaacgtuua 360

gtaauattaa agaauaguat ttgatttgut taaauaaagt agtaauagut gaagttuutt 420

uuaaatuaut tttutgattu tutaagaggu ttguutatgu uttguagatu taguttuauu 480

tauaagauat attutgtaag gatuuaggtt uaguaaggtg tuagaatgtu utaagggttt 540

utgtuucggc gututguutg tuucguttgt guauaatgut tttguutatu uutgtttutg 600

uatagatttt agtuttuuua uuagggacgu aautgtuagt ttuutucgtu tututcggtt 660

utattuuaat utgutuatut uuuutuucgt uuucgutttu uuuaaggauu tautgagatt 720

tcgatuuuau aauttagtgg gtuuuatutu auuuagguuu cguaatuutc guuttutaut 780

tgtuagcgtt gtautauaut utgaguaggu auuuutgtgu tautuacgga agcgggauua 840

ttaggtcggu uattuutuut uauuuuacga uacguauuua utgggtcggg ucguutuutt 900

guagggagtu tuaaggatgg gutggcgtua gggagggguu uagggggcgu tttuuuaaua 960

utggtcguag tuattgttgg tataacggut agagacguuu agtgagttag uatggagggu 1020

agtgggaucg gaaaaagacg tggaaaagut gcgaaaacga guuttcgaat uatggacgcg 1080

cggguuuagu tuutuutucg agttuutuat ucggggucgt uautuauatu cgggguuutu 1140

autuauatuc gggauuutua tucggggutu tuauuuauat ucgggauuut uatguutggg 1200

Claims

1.鉴定结肠直肠癌或它的前体、或结肠直肠癌的倾向的方法，包括：

在含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中，检测至少一种基因的外遗传沉默，所述至少一种基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655；

鉴定所述试样含有细胞，所述细胞是瘤性的、瘤的前体、或易于形成瘤，或者鉴定所述试样含有来自细胞的核酸，所述细胞是瘤性的、瘤的前体、或易于形成瘤。

2.权利要求1所述的方法，其中所述试样含有腺瘤细胞。

3.权利要求1所述的方法，其中所述试样含有来自腺瘤细胞的核酸。

4.权利要求1所述的方法，其中所述试样含有癌细胞或者来自癌细胞的核酸。

5.权利要求1所述的方法，其中所述至少一种基因是选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

6.权利要求1所述的方法，还包括步骤：

在所述含有结肠直肠细胞或者来自结肠直肠细胞的核酸的试样中，检测至少一种基因中的突变，所述至少一种基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655。

7.权利要求1所述的方法，其中所述试样来自新鲜或冷冻组织样品。

8.权利要求1所述的方法，其中所述试样来自活检样品。

9.权利要求1所述的方法，其中所述试样来自手术样品。

10.权利要求1所述的方法，其中所述试样来自细胞学样品。

11.权利要求1所述的方法，其中所述试样从体液中分离，所述体液选自：全血、骨髓、脑脊髓液、腹腔液、胸膜液、淋巴液、血清、粘液、血浆、尿液、乳糜、粪便、精液、痰、乳头抽吸液、唾液、拭样、结肠清洗样品和刷样。

12.权利要求8所述的方法，其中向所述患者推荐外科手术去除瘤性组织。

13.权利要求8所述的方法，其中向所述患者推荐辅助化疗。

14.权利要求8所述的方法，其中向所述患者推荐辅助放射治疗。

15.权利要求11所述的方法，其中向所述患者推荐结肠镜检查或者乙状结肠镜检查。

16.权利要求8所述的方法，其中向所述患者推荐增加频率的结肠镜检查。

17.权利要求11所述的方法，其中向所述患者推荐所述结肠的成像研究。

18.权利要求1所述的方法，其中检测至少两种基因的外遗传沉默。

19.权利要求1所述的方法，其中通过检测在所述基因中CpG二核苷酸基序的甲基化来检测外遗传沉默。

20.权利要求1所述的方法，其中通过检测在所述基因启动子中CpG二核苷酸基序的甲基化来检测外遗传沉默。

21.权利要求1所述的方法，其中通过检测所述基因减少的表达来检测外遗传沉默。

22.权利要求21所述的方法，其中通过检测所述基因减少的mRNA来检测外遗传沉默。

23.权利要求21所述的方法，其中通过与对照样品比较来测定所述基因减少的表达。

24.权利要求22所述的方法，其中通过与核苷酸探针杂交来检测所述基因减少的mRNA。

25.权利要求21所述的方法，其中通过核苷酸测序来检测减少的表达。

26.权利要求21所述的方法，其中通过反转录-聚合酶链式反应(RT-PCR)来检测减少的表达。

27.权利要求26所述的方法，其中所述RT-PCR是以非定量的方式进行。

28.权利要求26所述的方法，其中所述RT-PCR是以实时和定量的方式进行。

29.权利要求21所述的方法，其中通过检测所述基因编码的减少的蛋白质来检测外遗传沉默。

30.权利要求19所述的方法，其中甲基化通过将所述基因的至少一部分与甲基化敏感的限制性内切核酸酶接触来检测，所述内切核酸酶相对于非甲基化的识别位点优选地剪切甲基化的识别位点，由此所述基因的所述部分的剪切表明所述基因的所述部分的甲基化。

31.权利要求19所述的方法，其中甲基化通过将所述基因的至少一部分与甲基化敏感的限制性内切核酸酶接触来检测，所述内切核酸酶相对于甲基化的识别位点优选地剪切非甲基化的识别位点，由此所述基因的所述部分的剪切表明所述基因的所述部分的非甲基化，条件是所述基因包括所述甲基化敏感的限制性内切核酸酶识别位点。

32.权利要求19所述的方法，其中甲基化通过如下检测：

将所述测试细胞的基因的至少一部分与化学试剂接触，所述化学试剂相对于甲基化胞嘧啶残基选择性地修饰非甲基化的胞嘧啶残基，或相对于非甲基化胞嘧啶残基选择性地修饰甲基化的胞嘧啶残基；和

检测由于所述接触所产生的产物。

33.权利要求32所述的方法，其中所述检测步骤包括与至少一种探针杂交，所述探针与包括修饰的非甲基化的CpG二核苷酸基序的序列杂交，但是不与包括非修饰的甲基化CpG二核苷酸的序列杂交。

34.权利要求32所述的方法，其中所述检测步骤包括与至少一种探针杂交，所述探针与包括非修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的非甲基化CpG二核苷酸基序的序列杂交。

35.权利要求32所述的方法，其中所述检测步骤包括用至少一种引物扩增，由此形成扩增产物，所述引物与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括非修饰的甲基化CpG二核苷酸基序的序列杂交。

36.权利要求32所述的方法，其中所述检测步骤包括用至少一种引物扩增，由此形成扩增产物，所述引物与包括非修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的非甲基化CpG二核苷酸基序的序列杂交。

37.权利要求32所述的方法，其中所述产物通过选自电泳、杂交、扩增、引物延伸、测序、连接酶链反应、色谱、质谱和其组合的方法来检测。

38.权利要求37所述的方法，其中所述方法是绝对检测方法。

39.权利要求37所述的方法，其中所述方法是实时检测方法。

40.权利要求37所述的方法，其中所述方法对至少两种基因进行和比较所述至少两种基因产生的产物。

41.权利要求32所述的方法，其中所述化学试剂是肼。

42.权利要求41所述的方法，还包括用哌啶剪切所述肼接触的至少一部分的所述基因。

43.权利要求32所述的方法，其中所述化学试剂包括亚硫酸氢盐离子。

44.权利要求43所述的方法，还包括用碱处理所述亚硫酸氢盐离子接触的至少一部分的所述基因。

45.减少或者抑制细胞瘤性生长的方法，所述细胞显示了与癌症相关的至少一种基因的外遗传沉默转录，所述方法包括：

确定细胞具有外遗传沉默的基因，所述基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655；

通过将所述细胞与一种或者多种试剂接触，恢复在所述细胞中由所述外遗传沉默基因编码的多肽的表达，所述试剂选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂，

由此减少或抑制所述细胞不受调节的生长。

46.权利要求45所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

47.权利要求45所述的方法，其中所述接触在体外进行。

48.权利要求45所述的方法，其中通过将所述试剂给予含有所述细胞的哺乳动物对象在体内进行所述接触。

49.权利要求45所述的方法，其中所述试剂是脱甲基剂，并且所述试剂选自5-氮杂-2’-脱氧胞苷、5-氮杂-胞苷、泽布拉恩、普鲁卡因和L-乙硫氨酸。

50.减少或者抑制细胞瘤性生长的方法，所述细胞显示了至少一种与癌症相关的基因的外遗传沉默转录，所述方法包括：

确定细胞具有外遗传沉默的基因，所述基因选自：FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655；

将编码多肽的多核苷酸引入所述细胞，其中所述多肽由所述基因编码，其中所述多肽在所述细胞中表达，由此恢复所述多肽在所述细胞中的表达。

51.权利要求50所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

52.治疗癌症患者的方法，所述方法包括：

确定在所述患者中的癌细胞有外遗传沉默的基因，所述基因选自：FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655；

以足够量将一种或者多种选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂的试剂给予所述患者，以恢复所述外遗传沉默基因在所述患者癌细胞中的表达。

53.权利要求52所述的方法，其中所述试剂是脱甲基剂，和所述试剂选自5-氮杂-2’-脱氧胞苷、5-氮杂-胞苷、泽布拉恩、普鲁卡因和L-乙硫氨酸。

54.权利要求52所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

55.治疗癌症患者的方法，所述方法包括：

确定在所述患者中的癌细胞具有外遗传沉默的基因，所述基因选自：FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655所示的基因；

给予所述患者编码多肽的多核苷酸，其中所述多肽由所述外遗传沉默的基因编码，其中所述多肽在所述患者的肿瘤中表达，由此恢复所述多肽在所述癌中的表达。

56.权利要求55所述的方法，其中所述外遗传沉默的基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

57.选自治疗癌症患者的治疗策略的方法，包括：

鉴定基因，所述基因在所述患者的癌细胞中的表达被选自CpG二核苷酸脱甲基剂、DNA甲基转移酶抑制剂和组蛋白脱乙酰酶(HDAC)抑制剂的一种或者多种试剂再激活，其中所述基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655；和

选择增加所述基因表达以治疗所述癌症患者的治疗剂。

58.权利要求57所述的方法，其中所述基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

59.权利要求57所述的方法，还包括为所述癌症患者开处所述治疗剂的步骤。

60.权利要求57所述的方法，还包括给予所述癌症患者所述治疗剂的步骤。

61.权利要求57所述的方法，其中所述治疗剂包括编码所述基因的多核苷酸。

62.权利要求57所述的方法，其中所述脱甲基剂是5-氮杂-2’-脱氧胞苷。

63.权利要求57所述的方法，其中所述治疗剂是5-氮杂-2’-脱氧胞苷。

64.权利要求57所述的方法，其中所述癌细胞从手术样品获得。

65.权利要求57所述的方法，其中所述癌细胞从活检样品获得。

66.权利要求57所述的方法，其中所述癌细胞从细胞学样品获得。

67.权利要求57所述的方法，其中所述癌细胞从粪便、粘液、血清、血液或尿获得。

68.评定在试样中的甲基化的试剂盒，在包装中包括：

试剂，其(a)修饰甲基化的胞嘧啶残基，但是不修饰非甲基化的胞嘧啶残基，或(b)修饰非甲基化的胞嘧啶残基，但是不修饰甲基化的胞嘧啶残基；和

一对寡核苷酸引物，其在扩增条件下与基因的区域特异性杂交，所述基因选自FOXE1、SOX17、SYNE1、BOLL、CABYR、EFEMP1、FBLN2、FOXL2、GNB4、GSTM3、HoxD1、Jph3、神经化(NEURL)、PPP1R14a、TP53AP1、RAB32、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5、ARMCX2、CBR1、DDX43、DMRTB1、FBLN2、HIST2H2AA、ICAM1、LY6K、NEF3、POMC、STK31、SYCP3、TCL1A、TFPI-2、TLR2、UCHL1、ZFP42、ASCL2、ATP8A2、CTAG2、EPHA4、FANCF、FOXQ1、HUS1B、JAM3、LEF1、MOV10L1、NPPB、PWWP1、RASSF5、REC8L1、SALL4、BEX1、BNIP3、CCK、CDX1、CNN3、CXX1、IRX4、MC5R、RSNL2、SMARCA3、SPON1、SYT6、TRPC3、TSPYL6、ZNF345、DKK3和ZNF655所示的基因，其中所述区域在大约1kb的所述基因的转录起始位点内。

69.权利要求68所述的试剂盒，其中所述基因选自SYNE1、APC2、GPNMB、MMP2、EVL、STARD8、PTPRD、CD109、LGR6、RET、CHD5、RNF182、ICAM5。

70.权利要求68所述的试剂盒，其中所述寡核苷酸引物对中的至少一个引物与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，或者其中所述寡核苷酸引物对中的至少一个引物与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的非甲基化CpG二核苷酸基序的序列杂交。

71.权利要求68所述的试剂盒，还包括(a)第一寡核苷酸探针，其与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，(b)第二寡核苷酸探针，其与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，或(c)所述的第一和第二寡核苷酸探针两者。

72.权利要求68所述的试剂盒，还包括(a)第一寡核苷酸探针，其与包括修饰的非甲基化CpG二核苷酸基序的序列杂交，但是不与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，(b)第二寡核苷酸探针，其与包括未修饰的甲基化CpG二核苷酸基序的序列杂交，但是不与包括修饰的甲基化CpG二核苷酸基序的序列杂交，或(c)所述第一和第二寡核苷酸探针两者。

73.权利要求68所述的试剂盒，还包括寡核苷酸探针。

74.权利要求68所述的试剂盒，还包括用于扩增DNA的DNA聚合酶。