CN101674811B - 含有两种或更多种不同物理形态的活性药物成分的剂型 - Google Patents
含有两种或更多种不同物理形态的活性药物成分的剂型 Download PDFInfo
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- CN101674811B CN101674811B CN200880004561.1A CN200880004561A CN101674811B CN 101674811 B CN101674811 B CN 101674811B CN 200880004561 A CN200880004561 A CN 200880004561A CN 101674811 B CN101674811 B CN 101674811B
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- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2007900682 | 2007-02-09 | ||
| AU2007900682A AU2007900682A0 (en) | 2007-02-09 | Novel Formulation | |
| PCT/AU2008/000169 WO2008095263A1 (en) | 2007-02-09 | 2008-02-11 | A dosage form containing two or more active pharmaceutical ingredients in different physical forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101674811A CN101674811A (zh) | 2010-03-17 |
| CN101674811B true CN101674811B (zh) | 2015-08-19 |
Family
ID=39681201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880004561.1A Expired - Fee Related CN101674811B (zh) | 2007-02-09 | 2008-02-11 | 含有两种或更多种不同物理形态的活性药物成分的剂型 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9095519B2 (enExample) |
| EP (1) | EP2120878B1 (enExample) |
| JP (1) | JP5467870B2 (enExample) |
| CN (1) | CN101674811B (enExample) |
| AU (1) | AU2008213744B2 (enExample) |
| CA (1) | CA2677623C (enExample) |
| CY (1) | CY1115652T1 (enExample) |
| DK (1) | DK2120878T3 (enExample) |
| ES (1) | ES2522297T3 (enExample) |
| HR (1) | HRP20141008T1 (enExample) |
| NZ (1) | NZ599031A (enExample) |
| PL (1) | PL2120878T3 (enExample) |
| PT (1) | PT2120878E (enExample) |
| SI (1) | SI2120878T1 (enExample) |
| WO (1) | WO2008095263A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100189797A1 (en) * | 2002-06-10 | 2010-07-29 | Julien Mendlewicz | Oral antidepressant formulation |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| EP2184055A1 (en) * | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
| CN101780078B (zh) * | 2010-02-10 | 2012-02-29 | 威特(湖南)药业有限公司 | 替米沙坦和氨氯地平复方制剂及其制备方法 |
| EP2368543A1 (en) | 2010-03-25 | 2011-09-28 | KRKA, tovarna zdravil, d.d., Novo mesto | Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe |
| PL2857014T3 (pl) * | 2010-05-06 | 2016-12-30 | Kompozycja farmaceutyczna zawierająca aspirynę i bisoprolol | |
| CN102247366B (zh) * | 2010-05-18 | 2015-04-15 | 广州白云山制药股份有限公司广州白云山制药总厂 | 包括依那普利和非洛地平的药物组合物缓释制剂 |
| CN102028670A (zh) * | 2010-09-06 | 2011-04-27 | 邓俐丽 | 一种包含替米沙坦和钙离子通道拮抗剂的复方胶囊剂 |
| KR20120068277A (ko) * | 2010-12-17 | 2012-06-27 | 한미사이언스 주식회사 | ＨＭＧ－ＣｏＡ 환원효소 억제제 및 아스피린을 포함하는 약제학적 복합제제 |
| US9907789B2 (en) | 2011-10-21 | 2018-03-06 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| EP2793866B2 (en) | 2011-12-21 | 2023-10-25 | Elanco Tiergesundheit AG | Bilayer tablet comprising benazepril hydrochloride and pimobendan |
| CN103169704A (zh) * | 2011-12-26 | 2013-06-26 | 上海复星医药产业发展有限公司 | 烟酸和辛伐他汀复方缓释胶囊制剂及其制备方法 |
| EP2814465B1 (en) | 2012-02-17 | 2019-07-03 | Egis Gyógyszergyár Zrt. | Pharmaceutical formulation having improved stability |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| CN102670630B (zh) * | 2012-05-23 | 2013-11-27 | 重庆康刻尔制药有限公司 | 一种缬沙坦与氢氯噻嗪药物组合物胶囊剂及其制备方法 |
| WO2014033077A1 (en) * | 2012-08-28 | 2014-03-06 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Composition comprising an antibiotic and a beta-lactamase inhibitor, wherein at| least one of them is in the form of mini-tablets |
| EP2810644A1 (en) * | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
| HUP1300496A2 (hu) | 2013-08-16 | 2015-03-02 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Stabil kombinációs gyógyszerkészítmény |
| CN103462903B (zh) * | 2013-08-26 | 2016-06-22 | 中国人民解放军第150中心医院 | 一种盐酸吡格列酮缓释微丸制剂的制备工艺 |
| US9566248B2 (en) * | 2013-09-13 | 2017-02-14 | R.P. Scherer Technologies, Llc | Encased-pellet tablets |
| HU231036B1 (hu) * | 2013-09-30 | 2019-12-30 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Koleszterin bioszintézis gátló hatóanyagot és koleszterin abszorpciót gátló hatóanyagot tartalmazó kombinációs gyógyszerkészítmény |
| WO2015073573A1 (en) * | 2013-11-14 | 2015-05-21 | Jacobs Michael M | Compositions and methods for the prevention and treatment of alcohol-induced hangover syndrome |
| KR101910901B1 (ko) * | 2013-11-29 | 2018-10-24 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제 |
| CN104382896A (zh) * | 2014-11-04 | 2015-03-04 | 万全万特制药江苏有限公司 | 含有依折麦布和辛伐他汀的药物组合物 |
| MA44212A (fr) * | 2015-05-26 | 2018-12-26 | Isa Odidi | Prégabaline à libération prolongée contrôlée |
| WO2017023833A1 (en) * | 2015-08-01 | 2017-02-09 | Petti Stephen J | Compositions and methods for combination pharmacological treatments to induce a prolonged, mild decrease in core body temperature |
| FR3040303B1 (fr) * | 2015-08-27 | 2019-04-05 | Les Laboratoires Servier Suivi Par Sabine Goudeau-Wenger | Composition pharmaceutique comprenant un inhibiteur de la hmg-coa reductase et un inhibiteur eca |
| JP6831645B2 (ja) * | 2016-06-14 | 2021-02-17 | エルメッド株式会社 | ガランタミン含有医薬組成物、医薬組成物におけるガランタミンの安定化方法、及びガランタミンの安定化剤 |
| CN110913843B (zh) | 2017-07-17 | 2022-09-13 | 伊莱利利公司 | 药物组合物 |
| KR102500643B1 (ko) * | 2019-04-18 | 2023-02-16 | 한미약품 주식회사 | 에제티미브 및 로사르탄을 포함하는 약제학적 복합제제 |
| CN111388480B (zh) * | 2020-03-26 | 2022-05-31 | 江苏长泰药业有限公司 | 一种奥氮平盐酸氟西汀复方制剂及其制备方法 |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
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| CA2434169A1 (en) * | 2001-01-12 | 2002-07-18 | Sun Pharmaceutical Industries Limited | Spaced drug delivery system |
| WO2004062552A2 (en) * | 2003-01-09 | 2004-07-29 | Galephar M/F | Pharmaceutical composition containing a nsaid and a benzimidazole derivative |
| WO2004112756A1 (en) * | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| WO2005011642A1 (en) * | 2003-08-05 | 2005-02-10 | Galephar M/F | Single unit pharmaceutical composition comprising a mixture of a fibrate and an homocysteine reducing agent |
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| ATE197900T1 (de) | 1996-08-15 | 2000-12-15 | Losan Pharma Gmbh | Gut schluckbare orale arzneiform |
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| AR030920A1 (es) | 1999-11-16 | 2003-09-03 | Smithkline Beecham Plc | Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones |
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| DE60322091D1 (de) | 2002-10-25 | 2008-08-21 | Labopharm Inc | Zubereitungen mit kontrollierter freisetzung |
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-
2008
- 2008-02-11 HR HRP20141008AT patent/HRP20141008T1/hr unknown
- 2008-02-11 EP EP20080706056 patent/EP2120878B1/en not_active Not-in-force
- 2008-02-11 SI SI200831315T patent/SI2120878T1/sl unknown
- 2008-02-11 JP JP2009548549A patent/JP5467870B2/ja not_active Expired - Fee Related
- 2008-02-11 WO PCT/AU2008/000169 patent/WO2008095263A1/en not_active Ceased
- 2008-02-11 DK DK08706056T patent/DK2120878T3/da active
- 2008-02-11 AU AU2008213744A patent/AU2008213744B2/en not_active Ceased
- 2008-02-11 ES ES08706056.2T patent/ES2522297T3/es active Active
- 2008-02-11 PL PL08706056T patent/PL2120878T3/pl unknown
- 2008-02-11 CA CA2677623A patent/CA2677623C/en not_active Expired - Fee Related
- 2008-02-11 PT PT08706056T patent/PT2120878E/pt unknown
- 2008-02-11 CN CN200880004561.1A patent/CN101674811B/zh not_active Expired - Fee Related
- 2008-02-11 NZ NZ59903108A patent/NZ599031A/xx not_active IP Right Cessation
- 2008-02-11 US US12/526,326 patent/US9095519B2/en active Active
-
2014
- 2014-10-27 CY CY20141100879T patent/CY1115652T1/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5518187A (en) * | 1992-11-25 | 1996-05-21 | Nano Systems L.L.C. | Method of grinding pharmaceutical substances |
| CA2434169A1 (en) * | 2001-01-12 | 2002-07-18 | Sun Pharmaceutical Industries Limited | Spaced drug delivery system |
| WO2004062552A2 (en) * | 2003-01-09 | 2004-07-29 | Galephar M/F | Pharmaceutical composition containing a nsaid and a benzimidazole derivative |
| WO2004112756A1 (en) * | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| WO2005011642A1 (en) * | 2003-08-05 | 2005-02-10 | Galephar M/F | Single unit pharmaceutical composition comprising a mixture of a fibrate and an homocysteine reducing agent |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2120878T3 (da) | 2014-11-03 |
| HRP20141008T1 (hr) | 2015-01-02 |
| EP2120878A1 (en) | 2009-11-25 |
| CA2677623A1 (en) | 2008-08-14 |
| EP2120878A4 (en) | 2013-05-08 |
| WO2008095263A1 (en) | 2008-08-14 |
| CN101674811A (zh) | 2010-03-17 |
| US9095519B2 (en) | 2015-08-04 |
| CA2677623C (en) | 2015-04-07 |
| SI2120878T1 (sl) | 2014-12-31 |
| PT2120878E (pt) | 2014-11-05 |
| JP2010518028A (ja) | 2010-05-27 |
| ES2522297T3 (es) | 2014-11-14 |
| JP5467870B2 (ja) | 2014-04-09 |
| AU2008213744A1 (en) | 2008-08-14 |
| CY1115652T1 (el) | 2017-01-25 |
| US20100092549A1 (en) | 2010-04-15 |
| AU2008213744B2 (en) | 2013-12-05 |
| NZ599031A (en) | 2013-11-29 |
| PL2120878T3 (pl) | 2015-01-30 |
| EP2120878B1 (en) | 2014-07-30 |
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