CN101664540B - Orally-taken traditional Chinese medicine preparation used for aquiculture and preparation method thereof - Google Patents
Orally-taken traditional Chinese medicine preparation used for aquiculture and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an orally-taken traditional Chinese medicine preparation used for aquiculture and a preparation method thereof. The traditional Chinese medicine preparation comprises the Chinese medicine components such as radix curcumae, curcuma, white peony root, acanthopanax, schisandra and the like. The traditional Chinese medicine preparation has strong pertinence in curing symptomsof nonpathogenic diseases, can be used as feed additive, has little use amount, low cost and excellent protection effect if being added for long, can has an effect of prompting growth, and can be also used for curing diseases and conditioning after treatment; the oral-taking dose of the Chinese medicine preparation is extremely safe as the LD50(96h) is more than 1500mg.kg<-1> after the toxicity test is carried out, the oral-taking application has no problem of environmental pollution; and the Chinese medicine preparation achieves the granularity of 80-100 meshes by adopting a fine-grinding technology, is beneficial to being digested and absorbed by fish, and can play the effect of luring due to faint scent, thereby being beneficial to the fish to intake food.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to a kind of used for aquiculture innerwear Chinese medicine preparation and preparation method thereof.
Background technology
Current aquaculture has entered the high yielding culture period of high density and intensification.Because each monotechnics all more or less exists the limitation of technology, consider that when carrying out technical combinations favourable part is more, disadvantageous part is then out in the cold easily on the contrary.Therefore will occur such as a series of equilibrated phenomenons of cultivated animals internal and external environment that are unfavorable for such as high density, high protein, high pollution, high dispensers, thereby cause cultivated animals, comprise that a series of nonpathogenic disease such as " liver and gallbladder syndrome ", " stress syndrome ", " metabolic syndrome ", " medicine source property syndrome " appear in fish, shrimp, Eriocheir sinensis, Trionyx sinensis Wiegmann, the frog etc.Because this class disease mostly is the chronic disease that the cumulative bad damage causes greatly, and is so early symptom is not clearly, out in the cold easily.Along with PD, when liver and gall enlargement variable color occurring, body colour variation, body surface inflammation, are festered at gill filament variable color, body surface, internal organs hyperemia, when hemorrhage and dead successively, the then suitable difficulty of treatment.According to investigations, at the beginning of the spring and summer, the Fish morbidity is more than 25%, and at the beginning of autumn late summer, sickness rate is about 55%.
Above-mentioned nonpathogenic disease is because the cause of disease is confirmed relatively difficulty, and particularly therefore cause of disease chain intersection, complexity take combination of inner and outside method mostly aspect preventing and treating, and external chemicals or microorganism formulation improvement water quality reduce the toxicant in the breeding water body; The oral administration nutritional material and protect the liver, function of gallbladder promoting, disease-resistant medicine, to improve the health of animal body, impel body internal and external environment balance as far as possible.Common medicine for oral administration comprises following several substantially at present:
1, vitamin: as vitamin C, vitamin E, vitamin K and choline chloride etc.Vitamin is the necessary nourishing additive agent of aquatic feeds, is useful to animal body health.But if as medicine, see curative effect usually not too easily, and increase addition at double, both uneconomical, waste again.
2, synthetic drug: as bifendate, glucurolactone, methionine, inositol, the acid of gallbladder matter etc.This type of medicine has certain effect to slight liver-gallbladder disease mostly at the liver and gall pathological changes aspect preventing and treating.But this type of medicine all is ancillary drugs of treatment hepatopathy, as principal agent, is difficult to reach the effect that animal economy is adjusted, so curative effect and unstable.
3, Chinese medicine: be current quite active research and development field, from inspection information, the Chinese medicine of listing reaches kind more than 40, comprise that such as Radix Ginseng, Radix Angelicae Sinensis, Radix Isatidis, Radix Et Rhizoma Rhei, Radix Gentianae, Radix Glycyrrhizae, strand bone orchid, Radix Notoginseng, Radix Scutellariae etc. compound recipe cooperates as is that the liver and gall of principal agent must health with the Radix Isatidis, is the BAICAO gentian powder of principal agent with the Radix Gentianae, it with the Artemisia anethoicles Mattf liver and gall health of principal agent etc., be the product of medicine enterprise mostly, do not see the research experiment report, so be difficult to estimate.
Summary of the invention
Existing used for aquiculture oral preparations of the present invention such as vitamin are seen curative effect usually not too easily, and increase addition at double, both uneconomical, waste again, synthetic drug is difficult to reach the effect that animal economy is adjusted, and curative effect and instability and Chinese medicine are the product of medicine enterprise mostly, does not see the research experiment report, the deficiency that is difficult to estimate provides a kind of used for aquiculture innerwear Chinese medicine preparation and preparation method thereof.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of used for aquiculture innerwear Chinese medicine preparation comprises the Radix Curcumae of 22 weight portions～26 weight portions, the Rhizoma Curcumae Longae of 20 weight portions～24 weight portions, the Radix Paeoniae Alba of 8 weight portions～10 weight portions, the Radix Et Caulis Acanthopanacis Senticosi of 18 weight portions～22 weight portions and the Fructus Schisandrae Chinensis of 18 weight portions～20 weight portions.
The invention has the beneficial effects as follows: Chinese medicine preparation of the present invention is stronger to the symptom treatment specific aim of nonpathogenic disease, principal agent Radix Curcumae tool regulating qi to disperse stagnation, depressed liver-energy dispersing and function of gallbladder promoting, increases effects such as liver enzyme activity, blood fat reducing, antioxidation; Rhizoma Curcumae Longae is as liver-pacifying medicinal, and tool improves the sick damage of liver and gall parenchyma, the short metabolic function of function of gallbladder promoting; The accessory drugs Radix Paeoniae Alba plays nourishing blood to suppress the hyperactive liver, slow middle analgesic effect; Radix Et Caulis Acanthopanacis Senticosi is benefiting vital QI for tranquillizing, anti-stress, improve endocrine and pathological process played effects such as adjusting; The Fructus Schisandrae Chinensis nourishing kidney, promote the production of body fluid, promote liver glycogen generate to strengthen to decompose, tool adapts to the former state effect; The effect of Chinese medicine preparation of the present invention is screened according to folk prescription, prescription screening and the experiment of prescription CCl4 experimental liver injury model, and liver MDA generates inhibition test; Pilot scale effect test in fishpond has science.The consumption of Chinese medicine preparation of the present invention is few, can be used as feed additive, and it is low and protection effect is good to add cost for a long time, and still tool promotes the growth effect, also can be used for disease treatment and more back conditioning; After Chinese medicine preparation of the present invention carries out toxicity test, draw LD50 (96h)＞1500mg.kg-1 (be behind the 96h median lethal dose(LD 50) greater than 1500mg.kg-1), dosage for oral administration is very safe, the non-environmental-pollution problem of using for oral administration; Chinese medicine preparation of the present invention adopts the broken technology of micropowder to reach 80 orders～100 order granularities, helps the fish body and digests and assimilates, and have fragrant, and the food calling effect is arranged, and ingests so help Fish.
Further, described Chinese medicine preparation also comprises the yeast cell wall of 25 weight portions～30 weight portions.
Further, described Chinese medicine preparation also comprises the glucurolactone of 8 weight portions～10 weight portions and the feed yeast of 4 weight portions～6 weight portions.
The present invention also provides a kind of technical scheme that solves the problems of the technologies described above as follows: a kind of preparation method of used for aquiculture innerwear Chinese medicine preparation may further comprise the steps:
Step 1, Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis were carried out bake respectively 1.5 hours～2 hours in 75 ℃～80 ℃, make raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight;
Step 2, the raw material of Chinese medicine pulverize separately after the bake is become 80 orders～100 purpose Chinese medicine fine powders;
Step 3, the Chinese medicine fine powder that will pulverize take by weighing by the prescription of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions and 18 weight portions～20 weight portions;
Step 4, the Chinese medicine fine powder that will take by weighing mixed 20 minutes～24 minutes in 18 rev/mins～20 rev/mins mixing arrangement;
Step 5, use the mixing degree of the Chinese medicine fine powder of microscopic examination mix homogeneously, use dry weight-loss method to measure the moisture of Chinese medicine fine powder, pack after qualified.
Further, described step 1 comprises carried out bake respectively 1.5 hours～2 hours with Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis and yeast cell wall in 75 ℃～80 ℃, made raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight.
Further, described step 3 comprises that the Chinese medicine fine powder that will pulverize takes by weighing by the prescription of the yeast cell wall of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions, 18 weight portions～20 weight portions and 25 weight portions～30 weight portions.
Further, described step 1 comprises carried out bake respectively 1.5 hours～2 hours with Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, glucurolactone and feed yeast in 75 ℃～80 ℃, made raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight.
Further, described step 3 comprises that the Chinese medicine fine powder that will pulverize takes by weighing by the prescription of the feed yeast of the glucurolactone of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions, 18 weight portions～20 weight portions, 8 weight portions～10 weight portions and 4 weight portions～6 weight portions.
The specific embodiment
Below principle of the present invention and feature are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Embodiment 1
In the present embodiment, described used for aquiculture innerwear Chinese medicine preparation comprises the Radix Curcumae of 25 weight portions, the Rhizoma Curcumae Longae of 20 weight portions, the Radix Paeoniae Alba of 10 weight portions, the Radix Et Caulis Acanthopanacis Senticosi of 20 weight portions and the Fructus Schisandrae Chinensis of 20 weight portions.The Chinese medicine preparation of present embodiment is pressed 6mg/kg～12mg/kg body weight dosage, and promptly 0.2kg/T～0.4kg/T batch adds in the feedstuff.The Chinese medicine preparation of present embodiment had both belonged to the prevention type, belonged to therapeutic type again.
Embodiment 2
In the present embodiment, described used for aquiculture innerwear Chinese medicine preparation comprises the Radix Curcumae of 8 weight portions, the Rhizoma Curcumae Longae of 6 weight portions, the Radix Paeoniae Alba of 3 weight portions, the Radix Et Caulis Acanthopanacis Senticosi of 6 weight portions, the Fructus Schisandrae Chinensis of 6 weight portions and the yeast cell wall of 25 weight portions.The Chinese medicine preparation of present embodiment is pressed 24mg/kg～30mg/kg body weight dosage, and promptly 0.8kg/T～1kg/T batch adds in the feedstuff.The Chinese medicine preparation of present embodiment lays particular emphasis on booster immunization power type more.
Embodiment 3
In the present embodiment, described used for aquiculture innerwear Chinese medicine preparation comprises the Radix Curcumae of 8 weight portions, the Rhizoma Curcumae Longae of 7 weight portions, the Radix Paeoniae Alba of 5 weight portions, the Radix Et Caulis Acanthopanacis Senticosi of 5 weight portions, the Fructus Schisandrae Chinensis of 7 weight portions, the glucurolactone of 9 weight portions and the feed yeast of 21 weight portions.The Chinese medicine preparation of present embodiment is pressed 111mg/kg～120mg/kg body weight dosage, and promptly 3.7kg/T～4.0kg/T batch adds in the feedstuff.The Chinese medicine preparation of present embodiment lays particular emphasis on the reinforcement therapeutic type more.
Select medical material to do fish body folk prescription and prescription test by action principles such as Chinese medicine treating blood disorders, suppressing the hyperactive liver, function of gallbladder promoting, antioxidation, wind-damp dispelling.In containing 0.75mg/L nitrite water body, be base values with body weight rate of increase, sickness rate, mortality rate and disease, filter out Chinese medicines such as Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, and finished the prescription test in view of the above.
It is as follows to the repairing test of Fish anti-liver injury to have made Chinese medicine preparation of the present invention according to the pharmacology of Chinese materia medica experimental technique:
With carbon tetrachloride (CCL
4) the experimental liver injury model experiment, the Chinese medicine preparation of measuring embodiment 1 is to Ctenopharyngodon idellus serum transaminase (ALT) and serum urea nitrogen (BUN) level.Oral administration Chinese medicine preparation of the present invention after 15 days testing result see Table 1.
Table 1 Ctenopharyngodon idellus oral administration Chinese medicine preparation of the present invention testing result after 15 days
| Group | Dosage (mg.kg-1) | Serum ALT (U.L -1) | Improvement rate % | Serum BUN (mg.dl ') | Improvement rate % |
| Normal control | 22.12±5.43 | 7.51±2.64 | |||
| CCl 4Model | 0.02 | 163.22±18.93 | 1.79±0.43 | ||
| Low dose group | 3.0 | 156.28±11.22 | 4.28 | 2.45±1.25 | 26.93 |
| Middle dosage group | 6.0 | 48.68±7.54 | 70.18 | 6.85±2.06 | 73.86 |
| High dose group | 12.0 | 31.13±6.84 | 80.92 | 7.16±2.52 | 81.47 |
By table 1 result as seen, oral this product 6mg group of per kilogram fish body weight and 12mg group can significantly reduce CCl
4Hepatic injury Ctenopharyngodon idellus ALT content and increase BUN content, thus shown that liver, renal function to Ctenopharyngodon idellus have excellent repairing usefulness.
It is as follows to the inhibitory action test that liver malonaldehyde (MDA) generates to make Chinese medicine preparation of the present invention according to the pharmacology of Chinese materia medica method:
The radical pair histiocyte has stronger destruction, and the free radical accumulation is the basis that numerous disease takes place.The observation of cytolipin peroxide malonaldehyde level is the important indicator of research freedom base damage.So having carried out the Chinese medicine preparation fish body vivo medicine-feeding of embodiment 1 tested the liver MDA content influence after 15 days.The results are shown in Table 2, table 3 and table 4.
The external incubation experiment of table 2 is to the influence of Ctenopharyngodon idellus liver MDA content
| Group | Concentration mg.L -1 | MDA?nmol.ml -1 | Suppression ratio % |
| Normal saline | 26.80±0.68 | ||
| Low dosage | 3.0 | 9.66±0.90 | 63.95 |
| Middle dosage | 6.0 | 7.78±0.25 | 70.97 |
| High dose | 12.0 | 3.75±0.68 | 86.01 |
The external hydrogen peroxide of table 3 lures the influence of different experiment to Ctenopharyngodon idellus liver MDA content
| Group | Concentration mg.L -1 | MDA?nmol.ml -1 | Suppression ratio % |
| Normal saline | 32.8±1.24 | ||
| Low dosage | 3.0 | 11.70±1.63 | 64.33 |
| Middle dosage | 6.0 | 8.28±0.59 | 74.76 |
| High dose | 12.0 | 4.86±0.54 | 85.18 |
Table 4 oral administration is to CCl
4The influence of inducing the Ctenopharyngodon idellus liver MDA to generate
| Group | Dosage (mg.kg -1) | MDA?nmol.ml -1 |
| Contrast | 33.20±4.89 | |
| CCl 4 | 10 | 39.80±3.97 |
| CCl 4+ low dosage | 3.0 | 32.14±5.39 |
| CCl 4+ middle dosage | 6.0 | 25.04±5.01 |
| CCl 4+ high dose | 12.0 | 20.22±5.05 |
From table 2, table 3 as can be known, each dosage group of Chinese medicine preparation of the present invention all can significantly suppress the generation of hepatocyte MDA, and be dose dependent, it is closely related with inhibition adipose membrane matter peroxidation to show that Chinese medicine preparation of the present invention is eliminated the free radical effect, the experimental result of table 4 proves that further Chinese medicine preparation of the present invention can significantly resist CCl
4By increasing of Ctenopharyngodon idellus liver MDA content that radical reaction caused, show that Chinese medicine preparation of the present invention has the hepatic injury effect of certain free radical resisting mediation.
As follows according to fishpond intermediate experiment production and diseases prevention and treatment effect:
(1) Ctenopharyngodon idellus is cultured intermediate experiment
3 mouthfuls of test tanks, contrast Chi2Kou.4 mu in every pond, 1.3 meters～1.5 meters of the depth of waters, Ctenopharyngodon idellus 1200 tails of 200g～250g are put in every pond in a suitable place to breed.Duration of test, every month dispensing Operand sterilization 2 times, mixed feed protein content 26%, day feeding rate 3%.The test tank mixed feed adds the Chinese medicine preparation 200g per ton of embodiment 1; If fall ill in the fishpond, then add the Chinese medicine preparation of embodiment 3, interpolation 3.7kg per ton, 7 days was 1 course of treatment.JIUYUE 15 end of day were played in test from May 14.The results are shown in Table 5.
Table 5 Ctenopharyngodon idellus is cultured intermediate experiment
The result shows by table 5, and the Chinese medicine preparation of embodiment 1 is as additive, and the test tank of throwing something and feeding continuously 4 months, survival rate and rate of increase all are significantly higher than the contrast pond.The dysbolismus syndrome then takes place respectively before and after 3 months raising in the contrast pond, with basic controlling just after the Chinese medicine preparation treatment of embodiment 32 courses of treatment.
(2) crucian cultivation intermediate experiment
3 mouthfuls of test tanks, contrast Chi2Kou, 4 mu in every pond, 1.3 meters～1.5 meters of the depth of waters, 40g～50g Carassius auratus 8000 tails are put in every pond in a suitable place to breed.Mixed feed protein content 30%, rate 3% is raised in a day throwing.The test tank batch adds the Chinese medicine preparation material 1kg per ton of embodiment 2.Test from May 20 to JIUYUE 21 end of day, the results are shown in Table 6.
The intermediate experiment of table 6 crucian cultivation
The result shows as table 6, and the dysbolismus disease does not all take place the test tank of the Chinese medicine preparation of oral embodiment 2, and per mu yield and survival rate all are significantly higher than contrast.Treat 14 days state of an illness basic controlling with the Chinese medicine preparation of embodiment 3 immediately after contrasting morbidity, otherwise survival rate and output should reduce also.
Chinese medicine composition preparation of the present invention applicable cases example in aquaculture is as follows:
1,2004, stone protective embankment village, xiantao city, hubei province port town, a main Ctenopharyngodon idellus pond and main totally 50 mu in the Mylopharyngodon piceus pond of supporting of supporting caused and drawn in the net the irritability hemorrhagic disease because of liver-gallbladder disease takes place.The Chinese medicine preparation of Application Example 3 is cured after 1 wheat harvesting period treatment conditioning, and more than the 10 ten thousand jin of fishes in preceding two pools on May Day go out the pool smoothly then.
2,2004, the hemorrhage death of irritability took place in Ningxia Ning Chuan one band carp culture pond, and warp and feed factory cooperation are made additive with the Chinese medicine preparation of embodiment 2 and fed for a long time, have alleviated the puzzlement that perplexs the Huanghe valley, Yinchuan fisherman for many years.
3,2006, the chronic dysbolismus syndrome of the following Carnis Pseudosciaenae of 200g took place in Ningde City cage culture Carnis Pseudosciaenae culture zone, Fujian, and after course of treatment, the state of an illness is controlled through the Chinese medicine preparation of usefulness embodiment 3, and death stops.The prevention of regularly throwing something and feeding in every month afterwards, this disease take place again, and Carnis Pseudosciaenae grows fine.
4,2007, Jinxian County, Jiangxi Zhang, 30 mu in pond, the concurrent bacterial disease of liver and gallbladder syndrome takes place June, more than day dead hundred tails in the main Ctenopharyngodon idellus of supporting.The Chinese medicine preparation of Chinese medicine preparation treatment independent embodiment 3 of using after 5 days through add embodiment 1 with antimicrobial drug 15 days stops death.Regularly used the Chinese medicine preparation 5 days (200g/40kg feedstuff) of embodiment 1 in every month later on, to not morbidity again in October.This is prevented and treated method and uses equally in 1 mouthful of 45 mu of pond with village Wu, also obtains identical result.
5,2007, river, Yugan County, Jiangxi, the cage culture Monopterus albus (Zuiew), cause stress syndrome because of abrupt change of climate.Chinese medicine preparation 0.2g/kg body weight with embodiment 1 is mixed the bait feed, logotype 5 days, and the state of an illness is alleviated.
6,2008, Poyang County, Jiangxi Zhang, 10 mu of pond Ctenopharyngodon idellus morbidities are diagnosed as liver and gallbladder syndrome, the Chinese medicine preparation of use embodiment 1 10 days, consumption is the 150g/40kg feedstuff, the state of an illness is controlled fully.
7,2007, the Suixi Wang of Zhanjiang City, Guangdong cultured the Penaeus vannamei morbidity, is diagnosed as eperythrozoonosis, gill rot, hepatopathy, uses Chinese medicine preparation 8g every day that antimicrobial drug adds embodiment 3, logotype 5 days.The state of an illness is controlled as a result, ingests and recovers fully.
8,2007, the Guangdong Huizhou Boluo was supported the frog field bull frog disease is taken place, and is diagnosed as density excessive (20,000/mu) and water quality deterioration and causes the irritability syndrome.Water is changed in suggestion, after the modify-water, and the Chinese medicine preparation (3.7kg/T feedstuff) of embodiment 3 for oral administration, feed is 15 days continuously, and mortality is by dropping to 2kg/ day～3kg/ day 100kg/ day.
9,2008, symptoms such as the decortication of Trionyx sinensis Wiegmann body surface, furuncle, contrafluxion generally took place in Hubei Jing Shan production turtle-breeding field, dissected shallow, the enlargement of internal organs Hepatic.Be diagnosed as bacterial disease and metabolic syndrome is concurrent.Add the Chinese medicine preparation (3.7kg/T feedstuff) of embodiment 3 with antimicrobial drug, successive administration is after 5 days, and the state of an illness is alleviated, and uses the Chinese medicine preparation (1kg/T feedstuff) of embodiment 2 later on instead, take 10 days continuously after, death stops fully.
10, the present invention successively with the Guang Hui of Yunnan Province feed factory, the cooperations such as Guomei's feed factory, Wuhan City's Gekko Swinhonis feed factory, great river, Huaian, Jiangsu Province aquatic feeds company, the positive rainbow feedstuff in Wuhan company of newly having wished Hubei, Jiangxi, Hunan, in feedstuff, add the Chinese medicine preparation of embodiment 1.In the raiser, generally win the favorable judgment.
The above only is preferred embodiment of the present invention, and is in order to restriction the present invention, within the spirit and principles in the present invention not all, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. used for aquiculture innerwear Chinese medicine preparation, it is characterized in that described Chinese medicine preparation comprises the Radix Curcumae of 22 weight portions～26 weight portions, the Rhizoma Curcumae Longae of 20 weight portions～24 weight portions, the Radix Paeoniae Alba of 8 weight portions～10 weight portions, the Radix Et Caulis Acanthopanacis Senticosi of 18 weight portions～22 weight portions and the Fructus Schisandrae Chinensis of 18 weight portions～20 weight portions.
2. used for aquiculture innerwear Chinese medicine preparation according to claim 1 is characterized in that, described Chinese medicine preparation also comprises the yeast cell wall of 25 weight portions～30 weight portions.
3. used for aquiculture innerwear Chinese medicine preparation according to claim 1 is characterized in that, described Chinese medicine preparation also comprises the glucurolactone of 8 weight portions～10 weight portions and the feed yeast of 4 weight portions～6 weight portions.
4. the preparation method of a used for aquiculture innerwear Chinese medicine preparation is characterized in that, described preparation method may further comprise the steps:
Step 1, Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis were carried out bake 1.5 hours～2 hours respectively at 75 ℃～80 ℃, make raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight;
Step 2, the raw material of Chinese medicine pulverize separately after the bake is become 80 orders～100 purpose Chinese medicine fine powders;
Step 3, the Chinese medicine fine powder that will pulverize take by weighing by the prescription of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions and 18 weight portions～20 weight portions;
Step 4, the Chinese medicine fine powder that will take by weighing mixed 20 minutes～24 minutes in 18 rev/mins～20 rev/mins mixing arrangement;
Step 5, use the mixing degree of the Chinese medicine fine powder of microscopic examination mix homogeneously, use dry weight-loss method to measure the moisture of Chinese medicine fine powder, pack after qualified.
5. the preparation method of used for aquiculture innerwear Chinese medicine preparation according to claim 4, it is characterized in that, described step 1 comprises carried out bake 1.5 hours～2 hours with Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis and yeast cell wall respectively at 75 ℃～80 ℃, made raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight.
6. the preparation method of used for aquiculture innerwear Chinese medicine preparation according to claim 5, it is characterized in that described step 3 comprises that the Chinese medicine fine powder that will pulverize takes by weighing by the prescription of the yeast cell wall of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions, 18 weight portions～20 weight portions and 25 weight portions～30 weight portions.
7. the preparation method of used for aquiculture innerwear Chinese medicine preparation according to claim 4, it is characterized in that, described step 1 comprises carried out bake 1.5 hours～2 hours with Radix Curcumae, Rhizoma Curcumae Longae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, glucurolactone and feed yeast respectively at 75 ℃～80 ℃, made raw material of Chinese medicine water content after the bake be no more than 8%～10% of himself weight.
8. the preparation method of used for aquiculture innerwear Chinese medicine preparation according to claim 7, it is characterized in that described step 3 comprises that the Chinese medicine fine powder that will pulverize takes by weighing by the prescription of the feed yeast of the glucurolactone of the Fructus Schisandrae Chinensis of the Radix Et Caulis Acanthopanacis Senticosi of the Radix Paeoniae Alba of the Rhizoma Curcumae Longae of the Radix Curcumae of 22 weight portions～26 weight portions, 20 weight portions～24 weight portions, 8 weight portions～10 weight portions, 18 weight portions～22 weight portions, 18 weight portions～20 weight portions, 8 weight portions～10 weight portions and 4 weight portions～6 weight portions.
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| CN104543512B (en) * | 2014-12-24 | 2017-09-26 | 武汉华扬动物药业有限责任公司 | Improve Chinese herbal feed additive of fresh water aquiculture animal quality and preparation method thereof |
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| CN111358918A (en) * | 2020-05-13 | 2020-07-03 | 武汉华扬动物药业有限责任公司 | Traditional Chinese medicine oral liquid for preventing aquatic liver and gall syndrome and preparation method thereof |
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