CN105166567B - A kind of feed addictive and preparation method thereof for repairing the hepatic injury of grass carp drug induccd - Google Patents
A kind of feed addictive and preparation method thereof for repairing the hepatic injury of grass carp drug induccd Download PDFInfo
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- CN105166567B CN105166567B CN201510657918.8A CN201510657918A CN105166567B CN 105166567 B CN105166567 B CN 105166567B CN 201510657918 A CN201510657918 A CN 201510657918A CN 105166567 B CN105166567 B CN 105166567B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The present invention relates to a kind of feed addictives for repairing the hepatic injury of grass carp drug induccd, including glutathione, vitamin C, vitamin E, organic selenium, fructus lycii, Radix Astragali, soyabean protein powder, wheat-middlings, feed addictive of the present invention made of above-mentioned raw materials according to a certain percentage reasonable compatibility is added in feed of grass carp, the glutamic-oxalacetic transaminease of higher level can will be risen in grass carp body, glutamic-pyruvic transaminase and malonaldehyde are adjusted to normal level, there is good repair to the liver tissue lesions caused by the effect of medicine source sexual factor simultaneously, and the preparation method of feed addictive of the present invention is simple.
Description
[technical field]
The present invention relates to a kind of preparing grass carp feed additives more particularly to a kind of feed for repairing the hepatic injury of grass carp drug induccd to add
Add agent and preparation method thereof, belongs to feed additive field.
[background technique]
Grass carp is China year maximum freshwater aquiculture kind of cultured output, and Common Diseases type mainly includes thin in the cultivation phase
The diseases such as bacterium property disease, viral disease, parasitic disease.For the disease of above-mentioned grass carp three types, cultivates terminal and mainly adopt
Prevention and control are carried out with pharmaceutical means, wherein bacteriosis is mainly prevented and treated with antibiotics for oral administration, viral disease master
Active material is cooperated to be prevented and treated with Chinese herbal medicine, parasitic disease is mainly prevented and treated with for oral administration or outer bold and vigorous chemicals.
Fish liver is endotrophic metabolism center, is played a very important role in drug metabolism processes.One
As in the case of, according to disease type and drug indication, recommend the course for the treatment of to use by drug, drug is centainly controlled using rear equal can play
Therapeutic effect, drug can also be gradually removed in fish liver by bioconversion.However, when drug is more than in fish body cumulative amount
It when the physiological stress that liver converts drug metabolism, then can cause the medicine source hurt of Liver of Ctenopharyngodon Idellus, cause fish body to occur different
The human body energy and various nutrients dysbolism of degree.In recent years, due to objective the depositing of grass carp source pathogenic bacteria resistance to drugs problem
To drug use, there are Subjective mistaken ideas with cultivation terminal, in disease popularity phase or more disease concurrent phases, in order to better
Phenomena such as prevention and control state of an illness, the super course for the treatment of of drug, the use of super recommended dose and random compatibility, is more and more common in cultivation terminal, causes thus
A series of indirect hazard as during medication or after the medication phase shows as out of strength, appetite of moving about on grass carp biobehavioral
Decline, growth performance decline, are sensitive to environmental stress；Liver jaundice is shown as on pathomorphism or is whitened, and is occurred when serious green
Liver, hepatic tissue interstitial edema is broadening, liver cell enlargement, denaturation, necrosis etc.；It can lead to the raising of grass carp feed coefficient when serious,
The decline of per mu yield culture efficiency.Therefore, in order to avoid or reduce drug induccd hepatic injury potential hazard, improve grass carp digestic property and
Feed efficiency develops a kind of pair of Grass Carp Liver tissue the medicine source hurt feed addictive having repairing effect for effectively solving grass
Fish drug induccd hepatic injury is of great significance.
[summary of the invention]
In view of the above problems, the purpose of the present invention is to provide a kind of feed additions for repairing the hepatic injury of grass carp drug induccd
Agent.
To achieve the above object, the invention adopts the following technical scheme:
A kind of feed addictive for repairing grass carp drug induccd hepatic injury, comprises the following components in parts by weight: glutathione
2-4 parts, 20-40 parts of vitamin C, 5-10 parts of vitamin E, 5-10 parts of organic selenium, 3-8 parts of fructus lycii, 5-10 parts of Radix Astragali, soybean
2-6 parts of albumen powder, 20-50 parts of wheat-middlings.
Preferably, the vitamin C is vitamin C phosphoric ester, and the organic selenium is selenomethionine, and the dimension is raw
Plain E is vitamin e acetate.
Preferably, the albumen effective content of the soyabean protein powder is 55% or more.
Above-mentioned fructus lycii and Radix Astragali can be commercially available.
As a preferred embodiment, the feed addictive for repairing the hepatic injury of grass carp drug induccd, including following parts by weight
Component: it is 3-4 parts of glutathione, 30-32 parts of vitamin C, 6-8 parts of vitamin E, 5-6 parts of organic selenium, 6-8 parts of fructus lycii, yellow
7-9 parts of stilbene, 5-6 parts of soyabean protein powder, 30-40 parts of wheat-middlings.
Further, the present invention also provides a kind of careless fish feeds, which is characterized in that contains 0.1%- in the feed
The feed addictive of the above-mentioned reparation grass carp drug induccd hepatic injury of 0.5% (weight percent).
The present invention also provides a kind of preparation method of the feed addictive of above-mentioned reparation grass carp drug induccd hepatic injury, operations
Step are as follows: cross 80 meshes after fructus lycii and Radix Astragali are weighed respectively and carry out coarse powder, then given birth to respectively with glutathione, dimension in proportion
Plain C, vitamin E, organic selenium, soyabean protein powder, wheat-middlings are mixed, then are sieved with 100 mesh sieve and pulverized, and are uniformly mixed,
To obtain the final product.
The utility model has the advantages that
Compared with prior art, the invention has the following beneficial effects:
Glutathione that the present invention selects, vitamin C, vitamin E, organic selenium have significant antioxidant effect, both right
Excessive oxidation free radical has good elimination effect in grass carp body, also has good activation to liver cell；Soybean egg
White powder is a kind of high-quality protein source, and high conversion rate is utilized in grass carp body, can be liver cell activation and liver group after fish body absorbs
It knits reparation and a variety of amino acid or polypeptide moiety is provided；Fructus lycii and Radix Astragali contain active polysaccharide ingredient, have good physiology
Activity can enhance the non-specific immune function of grass carp and improve grass carp disease resistance, mention for drug induccd hepatic injury repair process
For good physiological foundation.Feed addictive of the present invention made of above-mentioned raw materials according to a certain percentage reasonable compatibility is added
It is added in feed of grass carp, the glutamic-oxalacetic transaminease, glutamic-pyruvic transaminase and malonaldehyde that higher level is risen in grass carp body can be adjusted
There is good repair to normal level, while to the liver tissue lesions caused by the effect of medicine source sexual factor.
In addition, feed addictive of the present invention is nontoxic, no pollution to the environment, belong to environmental type product, and make
Preparation Method is simple.
Detailed description of the invention
Fig. 1 is blood lipid of the grass carp of example 1 group in culture experiment of the present invention in on-test；
Fig. 2 is blood lipid of 2 groups of embodiment in culture experiment of the present invention of the grass carp in on-test；
Fig. 3 is blood lipid of the grass carp of control group in culture experiment of the present invention in on-test；
Fig. 4 is blood lipid of the grass carp of example 1 group in culture experiment of the present invention at on-test 15 days；
Fig. 5 is blood lipid of 2 groups of embodiment in culture experiment of the present invention of the grass carp at on-test 15 days；
Fig. 6 is blood lipid of the grass carp of control group in culture experiment of the present invention at on-test 15 days；
Fig. 7 is blood lipid of the grass carp of example 1 group in culture experiment of the present invention at on-test 20 days；
Fig. 8 is blood lipid of 2 groups of embodiment in culture experiment of the present invention of the grass carp at on-test 20 days；
Fig. 9 is blood lipid of the grass carp of control group in culture experiment of the present invention at on-test 20 days.
[specific embodiment]
Below in conjunction with specific embodiment, invention is further explained.In the case where not specified (NS), the present invention is real
Applying raw materials used in example is commercial product.
Embodiment 1
By weight, weigh respectively 2 parts of glutathione, 30 parts of vitamin C, 8 parts of vitamin E, 5 parts of selenomethionine,
3 parts of fructus lycii, 7 parts of Radix Astragali, 5 parts of soyabean protein powder (albumen effective content is 55%), 40 parts of wheat-middlings.By fructus lycii and Radix Astragali mistake
80 meshes carry out coarse powder, then respectively with glutathione, vitamin C, vitamin E, selenomethionine, soyabean protein powder, wheat-middlings into
Row mixing, then sieve with 100 mesh sieve and pulverized, it is uniformly mixed to get the feed addictive of grass carp drug induccd hepatic injury is repaired.
Embodiment 2
By weight, including following components, 3 parts of glutathione, 32 parts of vitamin C phosphoric ester, vitamin e acetate 6
Part, 6 parts of selenomethionine, 8 parts of fructus lycii, 9 parts of Radix Astragali, 6 parts of soyabean protein powder (albumen effective content is 59%), 30 parts of wheat-middlings.
Fructus lycii and Radix Astragali are crossed into 80 meshes and carry out coarse powder, then respectively with glutathione, vitamin C phosphoric ester, vitamin E acetic acid
Ester, selenomethionine, soyabean protein powder, wheat-middlings are mixed, then are sieved with 100 mesh sieve and pulverized, and are uniformly mixed to get reparation
The feed addictive of grass carp drug induccd hepatic injury.
Embodiment 3
By weight, including following components, 2 parts of glutathione, 40 parts of vitamin C phosphoric ester, vitamin e acetate 10
Part, 10 parts of selenomethionine, 6 parts of fructus lycii, 10 parts of Radix Astragali, 2 parts of soyabean protein powder (albumen effective content is 60%), wheat-middlings 20
Part.Fructus lycii and Radix Astragali are crossed into 80 meshes and carry out coarse powder, then respectively with glutathione, vitamin C phosphoric ester, vitamin E second
Acid esters, selenomethionine, soyabean protein powder, wheat-middlings are mixed, then are sieved with 100 mesh sieve and pulverized, and are uniformly mixed to get repairing
The feed addictive of multiple grass carp drug induccd hepatic injury.
Embodiment 4
By weight, including following components, 4 parts of glutathione, 20 parts of vitamin C, 5 parts of vitamin E, selenomethionine
8 parts, 5 parts of fructus lycii, 5 parts of Radix Astragali, 3 parts of soyabean protein powder (albumen effective content is 59%), 50 parts of wheat-middlings.By fructus lycii and Huang
Stilbene crosses 80 meshes and carries out coarse powder, then respectively with glutathione, vitamin C, vitamin E, selenomethionine, soyabean protein powder, secondary
Powder is mixed, then is sieved with 100 mesh sieve and pulverized, and is uniformly mixed the feed to get the hepatic injury of grass carp drug induccd is repaired and is added
Add agent.
Culture experiment
(1) test material and method
1.1 material
Test holds seed multiplication farm purchased from hundred with grass carp, and test is raised from the grass carp that market is bought with commodity with daily feed
Material, feeds utilized additive are to implement feed addictive made from 1 and implementation 2 in the present patent application.
1.2 method
1.2.1 test grouping and feeding management
Choose health, grass carp (55 ± 2g) of uniform size sets 5 processing groups (example 1 group, 2 groups of embodiment, embodiment
3 groups, 4 groups of embodiment and control group), 3 repetitions are arranged in each processing.100 tail of grass carp in each repeating groups, in outdoor net cage
Cultivation feeds domestication 5 days according to 3% feeding rate using daily feed, that is, is transferred to the formal test stage.During formal test,
It feeding three times daily, Feeding time is respectively 9:00,13:00,17:00, and breakfast and Chinese meal normally feed daily feed of grass carp,
During dinner, 3 processing groups feed the feed containing Ciprofloxacin with the final concentration of 30mg by every 1kg grass carp weight, continuously
It feeds 15 days.Formal test the 16th day, for feeding example 1 group, 2 groups of embodiment, 3 groups of embodiment, grass carp in 4 groups of embodiment
Feed in add respectively 0.1% embodiment 1 preparation additive, 0.3% embodiment 2 preparation additive, 0.4% embodiment
Additive prepared by the additive of 3 preparations, 0.5% embodiment 4, the feed for feeding grass carp in control group do not add any control
The additive for treating ingredient, continuously feeds 5 days, off-test.
Water temperature is 30 ± 3 DEG C, water pH value 7.0-7.4, molten oxygen≤7.0mg/L during test, and ammonia nitrogen≤0.1mg/L is sub-
Xiao Suan Yan≤0.05mg/L.
1.2.2 sample acquisition and detection
It fishes for 5 tail of grass carp at random from each group in 0d, 15d, 20d that formal test starts respectively, is acquired from tail vein non-
Anticoagulation, and it is centrifuged 10min through 5000rpm, the supernatant of acquisition is blood serum sample, is placed in -20 DEG C of preservations, detects its millet straw
Transaminase, glutamic-pyruvic transaminase, malonaldehyde activity.
The grass carp taken a blood sample in example 1 group, 2 groups of embodiment is dissected, takes grass carp hepatic tissue, is dyed using H&E
Histotomy is made, and observes each group grass carp blood lipid under the microscope.
(2) test result
2.1 glutamic-oxalacetic transamineases, glutamic-pyruvic transaminase, malonaldehyde determination result
The each group Grass Carp Serum glutamic-oxalacetic transaminease activity in different tests stage is as shown in table 1, when formal test starts, 5
Processing group Grass Carp Serum glutamic-oxalacetic transaminease activity difference is not significant；Continuously feed feed 15 days containing antibiotic ciprofloxacin
Afterwards, 5 processing group Grass Carp Serum glutamic-oxalacetic transaminease activity compared with on-test when have extremely significant raising, this illustrates serum millet straw
Transaminase activity variation has compared with hypersensitivity the antibiotic medicine fed, while also reflecting Liver of Ctenopharyngodon Idellus and medicine source occur
Property pathological change.When testing the 21st day, the Grass Carp Serum millet straw of example 1 group, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment
Transaminase activity is remarkably decreased, and control group Grass Carp Serum glutamic-oxalacetic transaminease activity is still maintained at higher level.This explanation,
The feed containing the feed addictive prepared in the embodiment of the present invention is fed, to the grass carp for continuously feeding antibiotic up to 15 days
Glutamic-oxalacetic transaminease activity has significant reducing effect.
The each group Grass Carp Serum glutamic-oxalacetic transaminease in 1 different tests stage of table is active (unit: U/mL)
The each group Grass Carp Serum gpt activity in different tests stage is as shown in table 2, when formal test starts, 5
Processing group Grass Carp Serum gpt activity difference is not significant；Continuously feed feed 15 days containing antibiotic ciprofloxacin
Afterwards, 5 processing group Grass Carp Serum gpt activities compared with on-test when have extremely significant raising, this illustrates serum paddy third
Transaminase activity variation has compared with hypersensitivity the antibiotic medicine fed, while also reflecting Liver of Ctenopharyngodon Idellus and medicine source occur
Property pathological change.When testing the 21st day, the Grass Carp Serum paddy third of example 1 group, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment
Transaminase activity is remarkably decreased, and control group Grass Carp Serum gpt activity is still maintained at higher level.This explanation,
The feed containing the feed addictive prepared in the embodiment of the present invention is fed, to the grass carp for continuously feeding antibiotic up to 15 days
Gpt activity has significant reducing effect.
The each group Grass Carp Serum gpt activity (unit: U/mL) in 2 different tests stage of table
The each group Grass Carp Serum mda content in different tests stage is as shown in table 3, when formal test starts, 5 processing
Group Grass Carp Serum mda content difference is not significant；After continuously feeding feed 15 days containing antibiotic ciprofloxacin, 5 processing
Group Grass Carp Serum mda content compared with on-test when have extremely significant raising, this illustrate serum malondialdehyde content variation to throwing
The antibiotic medicine fed has compared with hypersensitivity, while also reflecting grass carp body antioxidant system and the change of drug induccd pathology occur
Change.When testing the 21st day, example 1 group, 2 groups of embodiment, 3 groups of embodiment, the Grass Carp Serum mda content of 4 groups of embodiment are aobvious
Decline is write, and control group Grass Carp Serum mda content is still maintained at higher level.This explanation is fed containing of the invention real
The feed for applying the feed addictive prepared in example has the mda content for the grass carp that antibiotic was continuously fed up to 15 days aobvious
The regulating effect of work.
The each group Grass Carp Serum mda content (unit: mmol/mL) in 3 different tests stage of table
2.2 Grass Carp Liver histomorphometric analysis
As shown in Figure 1-3, when formal test starts, the Grass Carp Liver knot of tissue of example 1 group, 2 groups of embodiment and processing group
Structure is clear, and liver cell, hepatic sinusoid, central vein etc. have no obvious lesion.As Figure 4-Figure 6, it continuously feeds containing antibiosis prime ring
Behind feed 15 days of third husky star, there is liver cell nuclear pyknosis, the necrosis of being dispersed in property in the grass carp hepatic tissue of 3 processing groups, and liver is thin
The obvious vacuolation of born of the same parents, liver rope disorder, hepatic sinusoid atrophy.As Figure 7-9, compared with the control group, embodiment 1, reality are continuously fed
Behind feed 5 days for applying the feed addictive of the preparation of example 2, grass carp hepatic tissue is obviously improved, and hepatic sinusoid gap is broadening, and liver occurs for big portion
The tissue of Vacuole formation lesion subtracts rapidly recovery, and the grass carp hepatic tissue of control group part occurs and dyes light dye, and local liver is thin
Born of the same parents' denaturation, necrosis, liver Cable Structure disorder, the disorder of hepatic sinusoid normal configuration disappear.
The above, the preferable specific embodiment only invented, but scope of protection of the present invention is not limited thereto, appoints
What those familiar with the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its structure
Think of is subject to equivalent substitution or change, should be covered by the scope of protection of the present invention.
Claims (6)
1. a kind of feed addictive for repairing the hepatic injury of grass carp drug induccd, which is characterized in that be grouped as by the group of following parts by weight:
2-4 parts of glutathione, 20-40 parts of vitamin C, 5-10 parts of vitamin E, 5-10 parts of organic selenium, 3-8 parts of fructus lycii, Radix Astragali 5-
10 parts, 2-6 parts of soyabean protein powder, 20-50 parts of wheat-middlings.
2. the feed addictive according to claim 1 for repairing the hepatic injury of grass carp drug induccd, which is characterized in that the dimension
Raw element C is vitamin C phosphoric ester, and the organic selenium is selenomethionine, and the vitamin E is vitamin e acetate.
3. the feed addictive according to claim 2 for repairing the hepatic injury of grass carp drug induccd, which is characterized in that the soybean
The albumen effective content of albumen powder is 55% or more.
4. the feed addictive according to claim 3 for repairing the hepatic injury of grass carp drug induccd, which is characterized in that described to repair
The feed addictive of multiple grass carp drug induccd hepatic injury, is grouped as: 3-4 parts of glutathione, vitamin C by the group of following parts by weight
30-32 parts, 6-8 parts of vitamin E, 5-6 parts of organic selenium, 6-8 parts of fructus lycii, 7-9 parts of Radix Astragali, 5-6 parts of soyabean protein powder, wheat-middlings
30-40 parts.
5. a kind of grass fish feed, which is characterized in that any in the claim 1-4 in the feed containing 0.1%-0.5%
The feed addictive of reparation grass carp drug induccd hepatic injury described in.
6. the preparation method of the feed addictive of any of claims 1-4 for repairing the hepatic injury of grass carp drug induccd,
It is characterized in that, comprising the following steps: cross 80 meshes after fructus lycii and Radix Astragali are weighed respectively and coarse powder is made, then distinguish in proportion
Mixed with glutathione, vitamin C, vitamin E, organic selenium, soyabean protein powder, wheat-middlings, then sieve with 100 mesh sieve be made it is ultra-fine
Powder, be uniformly mixed to get.
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| CN110651917A (en) * | 2019-11-06 | 2020-01-07 | 无锡华诺威动物保健品有限公司 | Feed additive for protecting fish liver under oxidative stress condition and preparation method thereof |
| CN110916015A (en) * | 2019-11-27 | 2020-03-27 | 江苏三仪生物工程有限公司 | Additive for improving antioxidant stress capability of grass carp and preparation method thereof |
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| CN101559216A (en) * | 2009-05-08 | 2009-10-21 | 刘进辉 | Amino acid composition capable of protecting kidney and liver as well as promoting growth for animal and preparation technique thereof |
| CN101664540A (en) * | 2009-10-16 | 2010-03-10 | 武汉华扬动物药业有限责任公司 | Orally-taken traditional Chinese medicine preparation used for aquiculture and preparation method thereof |
| CN101822313A (en) * | 2010-05-10 | 2010-09-08 | 天津农学院 | Chinese medicament additive for improving liver function of Clarias lazera |
| CN102018137A (en) * | 2010-10-27 | 2011-04-20 | 西北农林科技大学 | Fish liver injury-resistant Chinese herb additive and preparation method thereof |
| CN102845635A (en) * | 2012-08-27 | 2013-01-02 | 广东海大集团股份有限公司 | Liver and body strengthening agent for Litopenaeus vannamei |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559216A (en) * | 2009-05-08 | 2009-10-21 | 刘进辉 | Amino acid composition capable of protecting kidney and liver as well as promoting growth for animal and preparation technique thereof |
| CN101664540A (en) * | 2009-10-16 | 2010-03-10 | 武汉华扬动物药业有限责任公司 | Orally-taken traditional Chinese medicine preparation used for aquiculture and preparation method thereof |
| CN101822313A (en) * | 2010-05-10 | 2010-09-08 | 天津农学院 | Chinese medicament additive for improving liver function of Clarias lazera |
| CN102018137A (en) * | 2010-10-27 | 2011-04-20 | 西北农林科技大学 | Fish liver injury-resistant Chinese herb additive and preparation method thereof |
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