CN101662999B - 用于经皮输送假体的输送工具 - Google Patents
用于经皮输送假体的输送工具 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/243—Deployment by mechanical expansion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
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- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
一种有助于在患者体内配置假体装置的可扩张输送工具。输送工具大致为细长形,并具有直径外扩的可选择扩张远端区段。一旦将输送装置经皮推动到患者血管内,输送装置可帮助确定目标区域,有助于在指定位置上配置假体并在配置后使假体进一步扩张。
Description
本申请已于2006年9月28日向美国作过申请,其标题为DeliveryToolForPercutaneousOfAProsthesis,美国临时申请系列号为60/827,373,在此将其参考引用。
发明背景
使用经皮接近法来研究并进行血管外科手术是经历过一次重大的运动过程的。比方说,通过将一个或多个导管穿过股动脉,就可将工具及装置输送到血管系统的指定区域以进行各种复杂的处理,而这在正常情况下是需要进行侵入外科处理的这种处理方法大大减轻了患者忍受的伤害,并明显缩短了恢复周期。用经皮接近法来取代心内直视术尤其引人注目。
瓣膜置换外科手术提供了一个研究经皮解决方法的示范性领域。多种疾病会导致心脏瓣膜小叶增厚及不动性或运动性降低。这种不动性还会导致瓣膜通道收缩或变窄。狭窄瓣膜引起血流阻力增大,最后引发心力衰竭并最终死亡。
治疗瓣膜狭窄或逆流要求通过心内直视术将已存在的自然瓣膜完全取出,并随后将假体瓣膜植入。很显然,这是一种侵入性处理并使人体承受严重损伤,通常会引起人体极度不适,并且恢复时间相当长。而且,它还是一种需要有丰富专业知识及技能的复杂的处理方法。
在过去,此种瓣膜置换外科手术是由传统的心内直视术来完成的,在手术中,要打开胸腔,使心脏停止跳动,使患者进行体外循环,将自然瓣膜切除并将置换瓣膜连接上。另一方面,美国专利6,168,614公开了另一种拟用经皮瓣膜置换方法,在此将其全文引用。在此专利中,假体瓣膜被装在一个可折叠的支架内,其中支架被折叠成适于装在导管内的尺寸。然后将导管插入患者维管结构内并将折叠支架移动到自然瓣膜的位置。启动配置机构,使含有置换瓣膜的支架扩张到瓣膜尖点。扩张结构包含有一个具有瓣膜形状且带有瓣膜小叶支承的支架,它们共同完成自然瓣膜的功能。这样,一个完整的瓣膜置换过程就已完成,而对患者的生理影响却大大减轻。
最新技术已对美国专利号6,168,614的内在缺陷进行了进一步改进。举例来说,在2006年5月26日提出申请的标题为StentlessSupportStructure的美国专利申请系列号11/443814中,采用了一种无支架支承结构方法,在此将参考引用其内容。无支架支承结构具有一种可在患者脉管内支承人造瓣膜或生物瓣膜的管状网格构架。该构架具有形状记忆特性,可促使构架长度折弯在自身上至少一次,并可在输送过程中多次折弯。鉴于此,就能以相当小的直径将构架经皮输送到目标区域,还可在脉管内扩张折叠以具有更大的直径及更大的强度。
通常要把无支架支承结构输送到患者体内患病瓣膜或机能低下瓣膜的位置。该结构扩张到自然瓣膜小叶上,并将其推到脉管侧面。当自然永久打开后,新瓣膜就取代自然瓣膜而开始起作用。在定位无支架支承结构时,最好将该结构经皮穿过患病瓣膜,对该结构远端进行配置,直到远端向外扩张开为止,然后把该结构向回拉并穿过患病瓣膜,直到使用者感觉到该结构张开远端触碰到患病瓣膜远侧为止。一旦确定结构张开远端已紧靠患病瓣膜远侧,那么结构的剩余部分就已被安置在患病瓣膜内。
在上述任一种经皮瓣膜装置移植处理中,对装置功能来说一个重大的问题就是移植的精确定位。如果该结构低于或高于最优装置位置,那么自然瓣膜小叶就有可能没有被假体支承结构捕获,而且还可进一步影响移植手术。此外,支承结构误定位可导致假体装置与附近心脏组织相互干扰,也可能会导致结构周围血液泄露并包围置换瓣膜。
要将这些装置精确定位在自然瓣膜内就需要有相当熟练的专业技能及训练,而且要获得成功的结果也要依赖于技术。因此就需要有一种输送工具更可靠地判定目标配置区域,并对经皮主动脉瓣膜置换装置或其它假体装置进行定位,其中,在移植过程中,这些装置的定位是非常关键的(比方说,一种用于心房间隔缺损、心室中隔缺损、心脏或维管结构卵圆孔未闭或穿孔的咬合器),然后输送工具还要对此装置进行配置以获得更可靠的移植结果。
发明概述
在某一实施例中,本发明提供了一种可扩张输送工具以将假体装置配置在患者体内。输送工具大致为细长形状,并且具有直径可外扩的可扩张远端区段。
一方面,该输送工具提供了预定目标区域如瓣膜的触觉指示。比如说,一旦把输送工具在患者血管内扩张开来,那么使用者就可将其向自己拉近,直到其接触到预定目标瓣膜为止。这种接触会被传导出来,从而使用者可在患者体外装置近端感知得到,这样就提供了一种预定目标位置已被确定的指示。
另一方面,该输送工具提供了一种固定止回器,可相对该固定止回器对假体进行配置,这样就进一步保证了假体被输送到患者体内的预定目标位置。比方说,把输送工具的扩张止回器定位在患者体内远离自然瓣膜的一个位置上。把假体配置在自然瓣膜内并使其紧靠扩张止回器,这样就确保了使假体保持在自然瓣膜内的设定目标位置。
再一方面,还可用该输送工具将假体配置后使其扩张。比如说,把可扩张止回器在尺寸上减小到预定扩张直径(也就是使用者想使假体扩张到的直径),然后透过配置假体拉动可扩张止回器,从而使假体直径扩张。这种扩张作用进一步把假体紧固到血管上,从而确保其位置不变并最大程度减少了假体周围产生泄漏的可能性。或者,可使输送工具远端在假体内扩张以使患者血管内的假体进一步扩张。
附图简介
图1为依据本发明某一优选实施例的一种输送工具的侧视图;
图2为图1所示输送工具的侧视图;
图3为图1所示输送工具的侧视图;
图4为依据本发明某一优选实施例的一种瓣膜假体的侧视图;
图5为依据本发明某一优选实施例的连接在支承结构上的一种锁销机构的侧视图;
图6为图5所示锁销机构的放大侧视图;
图7为图5所示锁销机构的侧面透视图;
图8为图5所示锁销机构的仰视透视图;
图9为图1所示输送工具的侧视图;
图10为图1所示输送工具的侧视图;
图11为图1所示输送工具的侧视图,其中瓣膜假体处于配置初始阶段;
图12为图1所示输送工具的侧视图,其中假体初始区段被进一步配置;
图13为图1所示输送工具的侧视图,其中假体初始区段被进一步配置;
图14为图1所示输送工具的侧视图,其中假体已缩回到模拟瓣膜部位;
图15为图1所示输送工具的侧视图,其中假体已被配置到模拟瓣膜部位;
图16为图1所示输送工具的侧视图,其中输送工具已从其扩张构型状态松弛开来;
图17为图1所示输送工具的侧视图,其中假体已被完全配置;
图18为图1所示输送工具的侧视图,其中输送工具已被拉入假体瓣膜内;
图19为图1所示输送工具的侧视图,其中输送工具已被拉入假体瓣膜内且被扩张以作为一种把装置充分安置在自然瓣膜内的手段;
图20为一个假体及图1所示输送工具的透视图;
图21为一个假体及图1所示输送工具的侧视图,其中输送工具已被从假体瓣膜处拉出来;
图22为一种具有网格的输送工具优选实施例的侧视图,其中网格被制成可扩张倒锥形;
图23为一种具有网格的输送工具优选实施例的侧视图,其中网格被制成锥形杯形状,但网格层没有倒置;
图24为一种输送工具优选实施例的侧视图,其中输送工具被构制为具有一系列用以定位及安置的超弹性线圈;
图25为一种输送工具优选实施例的侧视图,其中输送工具被构制为具有一系列用以定位及安置的球囊。
本发明详细说明
图1显示了依据本发明的一种可扩张输送工具100实施例。一般来说,可扩张输送工具100被移动式定位在患者血管内以助于把假体输送并定位在目标区域。正是由于这一点,使用者可更精确地配置假体,同时会最大程度地降低不想有的配置并发症。
可扩张输送工具100包括有一个可变性网格区段102,可变形网格区段102从图1所示缩径构型扩张为图2与图3所示扩径构型。通过增大或减小网格区段102近端与远端间的间距就可调整网格区段102的直径。具体来说,远端锚环104把网格区段102远端固定到控制线110上,控制线110穿过网格区段102且近端朝向使用者。外护套108沿控制线110滑动并被固定到近端锚环点106上。因此,使用者可使外护套108相对控制线110向远端移动以增大网格区段102的直径,还可使其相对控制线110向近端移动以减小网格区段102的直径。
可将多根细线编织在一起以形成大致筒形,从而生成网格区段102的网格。这些细丝可由镍钛诺等形状记忆材料制成,但也可使用不锈钢或聚合化合物等非形状记忆材料。应当注意的是,通过改变丝线特性就可改变网格区段102的强度和形状。比如说,可通过改变所用丝线材料、粗度、数量以及编织图型来调整网格区段102的柔性。
在某一更具体的实例中,网格区段102以每英寸8-10根丝线编织而成,每根丝线直径为0.008英寸且由镍钛诺线制成。这样制成的相交线间的编制夹角约为75度。
虽然对网格区段102进行了图示,但也可使用既可使此区段选择性扩张又可使充沛血液流过输送装置100的其它材料或布局。
可通过增加网格区段102长度并因而增大网格区段102端部间间距的方法,或者通过减小镍钛诺编织管编织夹角的方法来增大网格区段102扩张构型的最大直径。同理,可通过缩短网格区段102长度的方法或增大镍钛诺编织管编织夹角的方法来减小其最大直径。也就是说,网格区段102的长度以及编织夹角基本上决定了网格区段102所能取得的最大扩张直径。所以,可根据目标血管的直径来选择处理所用网格区段102的最大直径。
在图示实施例中,近端锚环106及远端锚环104都是金属卡箍,它们分别把网格区段102夹紧到外护套108和控制线110上。当然,也可使用其它紧固方法,比如用粘结法、焊接法或使用锁紧机构。
网格区段102的近端与远端可包括有射线不可透标志带(无图)以便在处理过程中在荧光检查下可视。比方说,可将这些射线不可透条带编入网格区段102中,或者用近端锚环106和远端锚环104将其包夹起来。这样,使用者就可更好地观察网格区段102的位置及其在患者体内的扩张状态。
图4显示了一种可由输送装置100输送并定位的假体实例。具体来说,该假体为无支架支承结构120,其可参见于2006年5月26日提出申请的、标题为StentlessSupportStructure的美国专利申请系列号11/443,814,在此将参考引用其内容。
如先前参考的美国专利申请系列号11/443,814所述,支承结构120通常被倒置或被向内折叠以在输送过程中形成多层支承结构。为帮助使用者取得所需的支承结构120构造,输送护套通常包括有可移动联接在支承结构120孔眼132上的连接构件或连结臂。这样,使用者就可操作支承结构120,将连接构件松脱开来,并最终把输送护套从患者处移除。
图5-8显示了输送护套连接构件124和支承结构120之间的一种可移除联接机构的优选实施例。具体来说,正如从图7和图8清楚地看到的那样,锁销机构130包括有一个第一夹爪构件136和一个第二夹爪构件138,第一夹爪构件136具有一个锁紧销134,第二夹爪构件138具有一个开孔140,当锁销机构130闭合时,开孔140会俘获锁紧销134。通过滑动调整装在连接构件124内的控制线(或控制杆),就可在打开位置和闭合位置(即松开位置和锁紧位置)之间移动夹爪构件136和138。控制线的远端被连接在夹爪构件136和138上,从而使夹爪构件136和138相对彼此移近或移远。
如图5与图6所示,锁销机构130穿过支承结构120的孔眼132。当锁销机构130处于闭合位置时,孔眼132被锁紧在连接构件124周围。当使用者想要松开支承结构120时,就打开夹爪构件136和138,以使孔眼132滑出锁紧销134。这样,使用者就可通过在人体外近端位置处移动控制线来有选择地松开支承结构120。
锁紧销134的纵轴优先垂直于连接构件124的纵轴。当机构130处于闭合位置时,由于锁紧销134由夹爪136及138共同支承,而且施加在锁紧销134上的合力垂直于锁紧销134的纵轴,所以锁销130在受载时不会被推动到打开位置。相应地,锁销机构130与孔眼132的连接稳固且牢不可破,除非使用者打开夹爪136、138将锁销机构130从孔眼132处松脱开来。
连接构件130构型及孔眼132定位的一个优势是:即使把全部三个连接构件130都联接到孔眼132上(参照图21),连接构件130和瓣膜小叶125工作也不会相互妨碍。此外,血液会流经输送机构周围并流过假体。因此,在放松之前可对假体工作及定位进行检验。如果假体位置不符合要求,或者瓣膜小叶125不工作,那么可将假体缩回到输送机构中。
也可用其它联接结构来固定或松开支承结构120。比如说,在连接构件124远端可具有挂钩或易断裂丝线以允许使用者有选择地松开支承结构120。
在此就不对装置的操作进行详细描述。参照9-21,图示输送工具100正把一个假体输送到表示患者体内自然瓣膜114(如主动脉瓣膜)的一段清洁管道。在此示例中,假体为先前所述无支架支承结构120。但应当理解的是,本发明可用于输送各种假体装置,包括先前讨论的Andersen的′614号专利所述支架装置,以及用于心脏或维管结构开孔或穿孔闭锁的其它装置。
导线及导引器的远端(图中没有画出)通常被送进到患者血管内的指定目标区域。在此示例中,目标区域就是自然瓣膜114。接下来,在导管上滑动输送护套112,直到其远端到达输送护套112的定位附近,然后去掉导线与导引器。
参照图9,推动输送工具100,使其通过输送护套112,直到网格区段102从输送护套112远端处出来并被传送到远离目标区域的一个位置为止(即穿过目标位置,在此示例中,目标位置指自然瓣膜114)。
现转到图10,使用者在控制线110近端处相对外护套108进行拉动,从而把输送工具100移到其扩张构型中。这样就把控制线108的远端移向外护套108端部,压缩了网格区段102的长度并增大或扩大了其直径。
如图11所示,无支架支承结构120(用于紧固置换瓣膜)被推出到输送护套112远端外部,直到其接触到输送工具100的网格区段102为止。如果它从输送护套112处继续前进,那么支承结构120直径就会扩张,如图12和13所示。这样,支承结构120就至少部分或者全部被远离自然瓣膜114配置。
接下来,用多个连接构件124从输送护套112处推动无支架支承结构120,从图18、20和21可清楚地看出来。每个连接构件124都被在其远端处可移除连接到无支架支承结构120上,并且可在输送护套112内纵向滑动。这样,即使结构120已被局部配置,使用者也可操作连接构件124的外露近端以推动无支架支承结构120并进而使其定位。一旦无支架支承结构120到达指定位置,并且假体工作也已得以检验,那么就可将连接构件124从结构120处松脱开来并从患者处移除。
参照图14,输送工具100以及无支架支承结构120都以近向缩向自然瓣膜114。由于输送工具100缩回,所以网格区段102的扩张直径就会接触自然瓣膜114以向使用者提供触觉指示。因而,当支承结构120到达自然瓣膜114内的指定目标位置时,使用者就会加以注意。
如本申请先前所述,无支架支承结构120被向内折叠在自身上以形成一个双层(甚至多层)支承结构。这种折叠构型使得无支架支承结构120在输送护套112内具有相当小的输送外形,但会增加壁厚。如果是由于支承结构120的形状记忆材料的预构型特性而使其自身产生折叠,那么就需要在远向上施加一个附加力以帮助支承结构120取得其最终构型。通常情况下,相对支承结构120推动输送护套112(即推动输送护套112或移动连接构件124)就可产生此种额外的力。但是,由输送护套造成的这种额外的运动会把支承结构120从自然瓣膜114处移出来,尤其是在远向上。
为了防止支承结构120的前述运动,就要把扩张网格区段102紧靠自然瓣膜114边沿而固定就位,从而防止支承结构120移除出来。也就是说,输送装置100的网格区段102作为一个固定止回器,防止了支承结构远向移出自然瓣膜114之外,并因而可使使用者更精确地判断患者体内支承结构120的配置位置。
在某些情况下,使用者可能只想把网格区段102调整到其收缩构型并将输送装置从患者处移除。而在其它情况下,使用者可能还想使支承结构120进一步扩张以提供相对自然瓣膜的附加紧固力,以确保自然瓣膜小叶继续被捕获在支承结构120下。
与筒形护套相类似,通过输送工具100的网格区段102就可使支承结构120进一步扩张。更具体地说,在远向上推动输送工具100,使其远离自然瓣膜114,如图15所示。如图16与17所示,网格区段102的直径已被缩减到支承结构120的指定目标直径(即使用者希望支承结构120扩张到的直径)。
参照图18与19,一旦已达到网格区段102的指定直径,使用者就通过支承结构120在近向上收缩输送装置100,这就使支承结构120进一步扩张到自然瓣膜114上。通过对图17所示透视图及图20做一比较,就可更好地显示出支承结构120产生的扩张。
如图21所示,如果通过支承结构120及自然瓣膜114一直拉动输送工具,那么网格区段102还可在直径上得以进一步缩减并被从患者处移除。最终,连接构件124可从支承结构120处松脱开来,并与输送护套112一起被除去。
通过初始减小网格区段102直径、把网格区段102放置在支撑结构120内,然后使网格区段102扩张到指定直径的方法也可使支承结构120取得相同的扩张效果。一旦取得支承结构120的预定扩张效果,就可将网格区段102直径减小并将其拉出患者体外。
本发明其它实施例可包括一种网格区段构型,该网格区段构型在扩张外形上形成多种形状并且可被用于其它应用(比如,可移植假体装置具有与支承结构120相似或不同的形状或结构)。举例来说,图22所示输送装置200基本上类似于先前所述输送装置,它还包括有一个连接在外护套204上的倒锥形网格区段202。这样,就可将网格区段202有选择地扩张成锥形以输送支承结构。
另外,在外护套204端部或输送装置200远端可包括有一个猪尾管206以作为一个缓冲器,从而最大程度降低了在其它情况下在输送时可由装置200远端引发的潜在伤害。猪尾管可由柔性聚合物短管制成,并大致呈弧形或圆形。
在另一实施例中,图23所示输送装置300包括有一个锥形杯状网格区段302,其基本类似于前述优选实施例100和200。同样地,装置300包括有一个外护套304,而且在装置300远端有一个猪尾管306,从而避免了对患者的伤害。但与输送装置200相对扁平远端不同,输送装置300倒置过来形成一个具有开放远端的杯形。
如图24所示,输送装置400的远端可被构型为具有分立支臂401,分立支臂401由柔性或超弹性线402制成。这些支臂401可如前述实施例般扩张及收缩,在外护套404或输送装置400的远端还安置有一个猪尾管406。
参照图25,输送装置500远端也可包括有一系列可扩张球囊502,这些可扩张球囊502一起链接到护套504上以提供与前述实施例类似的输送与定位功能,同时还可使血液流经球囊间隙。这些球囊502可以膨胀,并且还可用一个与前述实施例类似的机构使球囊502相对彼此进一步扩张。此外,在输送装置500远端可包括有一个猪尾管。
虽然附图只对无支架支承结构120进行了说明,但使用本发明同样可实现其它假体装置。比方说,可用输送工具100在功能低下目标瓣膜处配置一个带有联接置换瓣膜的支架。此外,可独立使用本装置以将其作为一种工具来进行主动脉球囊瓣膜成形术或其它要求在处理时具有装置孔隙及血液流通的球囊技术。
尽管已用特定实施例及应用对本发明进行了说明,但一个普通技术人员就可在不背离本发明精神或不超出本发明范围的情况下,根据本教义做出附加实施例及改变。相应地,应当理解的是,本文附图及文字说明只是作为示例以便于理解本发明,不应将其视为对本发明范围的限制。
Claims (4)
1.一种用以在血管系统内输送假体的柔性装置,其包括:
可通过维管的柔性输送护套;
一个具有贯通孔腔的柔性细长外护套;
一根置于所述孔腔内的控制线;以及
一个网格构件,其第一构型具有第一直径,其第二构型具有第二直径,所述第二直径大于所述第一直径;
其中所述控制线相对所述细长外护套的相对运动使网格构件在所述第一构型与所述第二构型之间变形;以及
支承结构被推出到输送护套的远端外部,直到其接触到输送装置的网格构件为止,并且支承结构被向内折叠在自身上以形成一个双层或多层支承结构,并且其中相对支承结构推动输送护套产生额外的力,并且输送装置的网格构件作为固定止回器,防止了由输送护套造成的这种额外的运动把支承结构远向移出自然瓣膜之外。
2.依据权利要求1所述装置,其中所述控制线的远端被固定到所述网格构件的远端上,所述细长外护套的远端被固定到所述网格构件的近端上。
3.依据权利要求1所述装置,其中所述网格构件的所述第二构型包括一个锥形杯状网格区段。
4.依据权利要求1所述装置,其中所述网格构件的所述第二构型包括一个倒锥形网格区段。
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- 2007-09-28 AU AU2007299934A patent/AU2007299934B2/en not_active Ceased
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- 2007-09-28 CA CA002664662A patent/CA2664662A1/en not_active Abandoned
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- 2007-09-28 JP JP2009530654A patent/JP5106537B2/ja not_active Expired - Fee Related
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2009
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2011
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2012
- 2012-08-13 JP JP2012179507A patent/JP5759949B2/ja not_active Expired - Fee Related
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JP5759949B2 (ja) | 2015-08-05 |
AU2007299934B2 (en) | 2013-09-12 |
AU2007299934A1 (en) | 2008-04-03 |
WO2008040014A3 (en) | 2008-07-03 |
JP2012236075A (ja) | 2012-12-06 |
JP2012236074A (ja) | 2012-12-06 |
IL214025A0 (en) | 2011-08-31 |
IL197867A (en) | 2017-04-30 |
EP2068764A2 (en) | 2009-06-17 |
JP2010505467A (ja) | 2010-02-25 |
IL197867A0 (en) | 2009-12-24 |
US20080082165A1 (en) | 2008-04-03 |
CA2664662A1 (en) | 2008-04-03 |
JP5106537B2 (ja) | 2012-12-26 |
BRPI0717540A2 (pt) | 2013-10-22 |
WO2008040014A2 (en) | 2008-04-03 |
EP2068764A4 (en) | 2016-07-27 |
JP2015128626A (ja) | 2015-07-16 |
CN101662999A (zh) | 2010-03-03 |
US20160220358A1 (en) | 2016-08-04 |
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