CN101636399B - 可用作plk1抑制剂的取代的嘧啶并二氮杂* - Google Patents

可用作plk1抑制剂的取代的嘧啶并二氮杂* Download PDF

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Publication number
CN101636399B
CN101636399B CN2008800088890A CN200880008889A CN101636399B CN 101636399 B CN101636399 B CN 101636399B CN 2008800088890 A CN2008800088890 A CN 2008800088890A CN 200880008889 A CN200880008889 A CN 200880008889A CN 101636399 B CN101636399 B CN 101636399B
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China
Prior art keywords
methyl
mol
tetrahydro
pyrimido
diazepine
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Expired - Fee Related
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CN2008800088890A
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English (en)
Chinese (zh)
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CN101636399A (zh
Inventor
蔡建平
陈少清
崔信洁
乐康
建春·托马斯·陆
彼得·米夏埃尔·沃库利希
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Takeda Pharmaceutical Co Ltd
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F Hoffmann La Roche AG
Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN2008800088890A 2007-03-22 2008-03-11 可用作plk1抑制剂的取代的嘧啶并二氮杂* Expired - Fee Related CN101636399B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22
US60/919,358 2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en) 2007-03-22 2008-03-11 Substituted pyrimidodiazepines useful as plk1 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210030872.3A Division CN102746175B (zh) 2007-03-22 2008-03-11 可用作plk1抑制剂的取代的嘧啶并二氮杂*

Publications (2)

Publication Number Publication Date
CN101636399A CN101636399A (zh) 2010-01-27
CN101636399B true CN101636399B (zh) 2012-04-18

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ID=39415299

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CN201210030872.3A Expired - Fee Related CN102746175B (zh) 2007-03-22 2008-03-11 可用作plk1抑制剂的取代的嘧啶并二氮杂*
CN2008800088890A Expired - Fee Related CN101636399B (zh) 2007-03-22 2008-03-11 可用作plk1抑制剂的取代的嘧啶并二氮杂*

Family Applications Before (1)

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CN201210030872.3A Expired - Fee Related CN102746175B (zh) 2007-03-22 2008-03-11 可用作plk1抑制剂的取代的嘧啶并二氮杂*

Country Status (23)

Country Link
US (1) US7517873B2 (OSRAM)
EP (1) EP2139892B1 (OSRAM)
JP (1) JP5087640B2 (OSRAM)
KR (1) KR101157848B1 (OSRAM)
CN (2) CN102746175B (OSRAM)
AR (1) AR065794A1 (OSRAM)
AT (1) ATE524472T1 (OSRAM)
AU (1) AU2008228303B2 (OSRAM)
BR (1) BRPI0809088A2 (OSRAM)
CA (1) CA2680757A1 (OSRAM)
CL (1) CL2008000785A1 (OSRAM)
CY (1) CY1112102T1 (OSRAM)
DK (1) DK2139892T3 (OSRAM)
ES (1) ES2371832T3 (OSRAM)
HR (1) HRP20110807T1 (OSRAM)
IL (1) IL200617A (OSRAM)
MX (1) MX2009010034A (OSRAM)
PE (1) PE20120495A1 (OSRAM)
PL (1) PL2139892T3 (OSRAM)
PT (1) PT2139892E (OSRAM)
SI (1) SI2139892T1 (OSRAM)
TW (1) TWI363629B (OSRAM)
WO (1) WO2008113711A1 (OSRAM)

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CN101952291A (zh) 2007-08-15 2011-01-19 弗特克斯药品有限公司 用作人蛋白激酶plk1至plk4的抑制剂以治疗增殖疾病的4-(9-(3,3-二氟环戊基)-5,7,7-三甲基-6-氧代-6,7,8,9-四氢-5h-嘧啶并[4,5-b][1,4]二氮杂䓬-2-基氨基)-3-甲氧基苯甲酰胺衍生物
US8026234B2 (en) * 2007-09-25 2011-09-27 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
EP2610256B1 (en) 2007-09-28 2016-04-27 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
US20090291938A1 (en) * 2007-11-19 2009-11-26 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
EP2303889A1 (en) 2008-06-18 2011-04-06 F. Hoffmann-La Roche AG Halo-substituted pyrimidodiazepines as plkl inhibitors
CA2745295C (en) * 2008-12-09 2017-01-10 Gilead Sciences, Inc. Modulators of toll-like receptors
EP3255047B1 (en) 2009-01-06 2021-06-30 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and uses in treating disorders
SG10201405826RA (en) 2009-06-17 2014-12-30 Vertex Pharma Inhibitors of influenza viruses replication
PT2477987T (pt) 2009-09-14 2018-03-13 Gilead Sciences Inc Moduladores de recetores do tipo toll
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3388436B1 (en) 2013-03-15 2020-08-12 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
MX2016001037A (es) 2013-07-25 2016-11-10 Dana Farber Cancer Inst Inc Inhibidores de factores de transcripción y usos.
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
WO2015073481A1 (en) 2013-11-13 2015-05-21 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3099693A4 (en) * 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
US10150756B2 (en) 2014-01-31 2018-12-11 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
MA40238A (fr) 2014-07-11 2017-05-17 Gilead Sciences Inc Modulateurs de récepteurs de type toll pour le traitement du vih
RU2017104897A (ru) 2014-08-08 2018-09-10 Дана-Фарбер Кэнсер Инститьют, Инк. Производные диазепана и их применения
US9573952B2 (en) 2014-09-16 2017-02-21 Gilead Sciences, Inc. Methods of preparing toll-like receptor modulators
BR102015023450A2 (pt) 2014-09-16 2016-04-12 Gilead Sciences Inc formas sólidas de um modulador do receptor semelhante a toll
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
CA2986441A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
PE20181287A1 (es) 2015-09-11 2018-08-07 Dana Farber Cancer Inst Inc Ciano tienotriazolpirazinas y usos de las mismas
US10913752B2 (en) 2015-11-25 2021-02-09 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibitors and uses thereof
JP6968819B2 (ja) * 2016-04-07 2021-11-17 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッドDana−Farber Cancer Institute, Inc. ピリミド−ジアゼピノンキナーゼ骨格化合物およびｐｉ３ｋ媒介性障害の治療方法
CA3150316A1 (en) * 2019-09-27 2021-04-01 Dana-Farber Cancer Institute, Inc. ERK5 DEGRADING AGENTS USED AS THERAPEUTIC AGENTS IN CANCER AND INFLAMMATORY DISEASES
WO2021194318A1 (en) * 2020-03-27 2021-09-30 Uppthera Plk1 selective degradation inducing compound
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
EP4157850A4 (en) * 2021-08-10 2024-11-20 Uppthera, Inc. Novel plk1 degradation inducing compound
GB202313514D0 (en) 2023-09-05 2023-10-18 Cambridge Entpr Ltd Treatment of inflammatory diseases

Citations (2)

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CN1390220A (zh) * 1999-09-17 2003-01-08 艾博特股份有限两合公司 作为治疗剂的激酶抑制剂
CN1551881A (zh) * 2001-09-04 2004-12-01 ���ָ��Ӣ��ķ�������Ϲ�˾ 新颖二氢喋啶酮,其制备方法及作为药物组合物的用途

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TW200808325A (en) 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1390220A (zh) * 1999-09-17 2003-01-08 艾博特股份有限两合公司 作为治疗剂的激酶抑制剂
CN1551881A (zh) * 2001-09-04 2004-12-01 ���ָ��Ӣ��ķ�������Ϲ�˾ 新颖二氢喋啶酮,其制备方法及作为药物组合物的用途

Also Published As

Publication number Publication date
AU2008228303B2 (en) 2012-04-19
AU2008228303A1 (en) 2008-09-25
MX2009010034A (es) 2009-10-12
DK2139892T3 (da) 2011-12-12
HRP20110807T1 (hr) 2011-12-31
CN102746175A (zh) 2012-10-24
AR065794A1 (es) 2009-07-01
KR20090119913A (ko) 2009-11-20
US7517873B2 (en) 2009-04-14
HK1139936A1 (en) 2010-09-30
IL200617A (en) 2014-02-27
US20080234255A1 (en) 2008-09-25
KR101157848B1 (ko) 2012-07-11
PE20120495A1 (es) 2012-05-12
SI2139892T1 (sl) 2011-12-30
IL200617A0 (en) 2010-05-17
CN101636399A (zh) 2010-01-27
TWI363629B (en) 2012-05-11
CA2680757A1 (en) 2008-09-25
CN102746175B (zh) 2014-01-15
BRPI0809088A2 (pt) 2014-09-09
PT2139892E (pt) 2011-11-21
EP2139892A1 (en) 2010-01-06
EP2139892B1 (en) 2011-09-14
WO2008113711A1 (en) 2008-09-25
TW200843781A (en) 2008-11-16
CL2008000785A1 (es) 2009-03-27
CY1112102T1 (el) 2015-11-04
JP2010521514A (ja) 2010-06-24
ATE524472T1 (de) 2011-09-15
JP5087640B2 (ja) 2012-12-05
PL2139892T3 (pl) 2012-03-30
ES2371832T3 (es) 2012-01-10

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