CN101622274A - 转铁蛋白融合蛋白库 - Google Patents

转铁蛋白融合蛋白库 Download PDF

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Publication number
CN101622274A
CN101622274A CN200780050623A CN200780050623A CN101622274A CN 101622274 A CN101622274 A CN 101622274A CN 200780050623 A CN200780050623 A CN 200780050623A CN 200780050623 A CN200780050623 A CN 200780050623A CN 101622274 A CN101622274 A CN 101622274A
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China
Prior art keywords
fusion protein
transferrin
amino acid
protein
moiety
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Pending
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CN200780050623A
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English (en)
Chinese (zh)
Inventor
安德鲁·J·特纳
王百扬
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Biorexis Pharmaceutical Corp
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Biorexis Pharmaceutical Corp
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Publication of CN101622274A publication Critical patent/CN101622274A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200780050623A 2006-12-12 2007-12-07 转铁蛋白融合蛋白库 Pending CN101622274A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93495106P 2006-12-12 2006-12-12
US60/934,951 2006-12-12

Publications (1)

Publication Number Publication Date
CN101622274A true CN101622274A (zh) 2010-01-06

Family

ID=39362844

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780050623A Pending CN101622274A (zh) 2006-12-12 2007-12-07 转铁蛋白融合蛋白库

Country Status (13)

Country Link
US (1) US8822639B2 (enExample)
EP (2) EP2114999A2 (enExample)
JP (1) JP5492563B2 (enExample)
KR (1) KR20090098880A (enExample)
CN (1) CN101622274A (enExample)
AU (1) AU2007331195A1 (enExample)
CA (1) CA2673085C (enExample)
ES (1) ES2535358T3 (enExample)
IL (1) IL198815A0 (enExample)
MX (1) MX2009006398A (enExample)
NO (1) NO20092591L (enExample)
WO (1) WO2008072075A2 (enExample)
ZA (1) ZA200904757B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258767A (zh) * 2010-05-24 2011-11-30 黄敏铨 促进伤口愈合的组合物
CN107075507A (zh) * 2014-11-10 2017-08-18 小利兰斯坦福大学理事会 用于在细胞表面上表达多肽的组合物和方法
CN109641971A (zh) * 2016-08-25 2019-04-16 Jcr制药股份有限公司 抗体融合蛋白的制造方法
CN113045670A (zh) * 2019-12-27 2021-06-29 华南农业大学 一种可溶性鸡α干扰素融合蛋白及其生产方法与应用
CN113811542A (zh) * 2018-12-21 2021-12-17 非营利性组织佛兰芒综合大学生物技术研究所 包含细胞因子和支架蛋白的融合蛋白

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US8401798B2 (en) * 2008-06-06 2013-03-19 Dna Twopointo, Inc. Systems and methods for constructing frequency lookup tables for expression systems
AU2010306940A1 (en) 2009-10-12 2012-06-07 Smith, Larry Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
US20130251740A1 (en) * 2010-10-26 2013-09-26 Rockefeller University (The) Immunogenic agents
CA2825641C (en) * 2011-02-02 2016-10-11 Medipost Co., Ltd. Use of icam-1 for prevention or treatment of neurological diseases
US9623117B2 (en) * 2011-04-04 2017-04-18 Wisconsin Alumni Research Foundation Method for selective targeting and entry of bacterial toxins to cells
SI3401402T1 (sl) * 2012-06-08 2021-03-31 Alkermes Pharma Ireland Limited Ligandi modificirani s krožno permutacijo kot agonisti in antagonisti
EP2929351B1 (en) * 2012-12-10 2019-10-09 The University of Queensland Cell-free biofragment compositions and related systems, devices, and methods
EP3438254A4 (en) * 2016-03-30 2019-10-16 Kaneka Corporation POLYPEPTIDE WITH ENDONUCLEASE ACTIVITY AND MANUFACTURING METHOD THEREFOR
EP4314073A4 (en) 2021-03-24 2025-02-19 Alkermes, Inc. Upar antibodies and fusion proteins with the same
US20250041398A1 (en) * 2021-12-16 2025-02-06 Thomas Jefferson University A therapeutic against crimean-congo hemorrhagic fever virus

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258767A (zh) * 2010-05-24 2011-11-30 黄敏铨 促进伤口愈合的组合物
CN102258767B (zh) * 2010-05-24 2013-05-15 黄敏铨 促进伤口愈合的组合物
CN107075507A (zh) * 2014-11-10 2017-08-18 小利兰斯坦福大学理事会 用于在细胞表面上表达多肽的组合物和方法
US10829771B2 (en) 2014-11-10 2020-11-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for expressing polypeptides on the surface of cells
CN107075507B (zh) * 2014-11-10 2021-08-24 小利兰斯坦福大学理事会 用于在细胞表面上表达多肽的组合物和方法
CN109641971A (zh) * 2016-08-25 2019-04-16 Jcr制药股份有限公司 抗体融合蛋白的制造方法
CN109641971B (zh) * 2016-08-25 2023-04-04 Jcr制药股份有限公司 抗体融合蛋白的制造方法
CN113811542A (zh) * 2018-12-21 2021-12-17 非营利性组织佛兰芒综合大学生物技术研究所 包含细胞因子和支架蛋白的融合蛋白
CN113045670A (zh) * 2019-12-27 2021-06-29 华南农业大学 一种可溶性鸡α干扰素融合蛋白及其生产方法与应用
CN113045670B (zh) * 2019-12-27 2022-11-01 华南农业大学 一种可溶性鸡α干扰素融合蛋白及其生产方法与应用

Also Published As

Publication number Publication date
KR20090098880A (ko) 2009-09-17
EP2114999A2 (en) 2009-11-11
US20110086768A1 (en) 2011-04-14
MX2009006398A (es) 2009-06-23
CA2673085A1 (en) 2008-06-19
JP5492563B2 (ja) 2014-05-14
EP2479189B1 (en) 2015-02-25
US8822639B2 (en) 2014-09-02
ES2535358T3 (es) 2015-05-08
AU2007331195A1 (en) 2008-06-19
IL198815A0 (en) 2011-08-01
WO2008072075A3 (en) 2008-11-06
EP2479189A1 (en) 2012-07-25
WO2008072075A2 (en) 2008-06-19
NO20092591L (no) 2009-09-11
CA2673085C (en) 2013-10-15
JP2010512160A (ja) 2010-04-22
ZA200904757B (en) 2010-04-28

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